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1.
Huang, Qi.
Application of Xanthates to the Synthesis of Azaindanes and to the C-H Functionalization of Heteroaromatics : Application des Xanthates à la Synthèse des Azaindanes et à la Fonctionnalisation C-H des Hétéroaromatiques.
Degree: Docteur es, Chimie, 2017, Université Paris-Saclay (ComUE)
URL: http://www.theses.fr/2017SACLX114 
► Dans cette thèse, nous avons entrepris une aventure pour découvrir une application plus large de la chimie du xanthate dans la construction de cycles fusionnés…
(more)
▼ Dans cette thèse, nous avons entrepris une aventure pour découvrir une application plus large de la chimie du xanthate dans la construction de cycles fusionnés et l'alkylation directe des hétéroarènes. Au chapitre II, nous avons abordé le problème de la préparation de l'azaindane en tirant parti de la capacité des xanthates à agir à la fois sur l'addition intermoléculaire et la cyclisation intramoléculaire. Au chapitre III, une étude sans précédent sur la fonctionnalisation directe des pyrazines a été décrite, conduisant à des pyrazines hautement fonctionnalisées avec de bons rendements et une bonne régiosélectivité. Enfin, au chapitre IV, nous avons développé une méthode de méthylation et de fluorométhylation des hétéroarènes.
In this thesis, we have undertaken an adventure to discover wider application of xanthate chemistry in the construction of fused cycles and direct alkylation of heteroarenes. In Chapter II, we have tackled the problem of preparation of azaindane by taking advantage of the ability of xanthates to mediate both intermolecular addition and intramolecular cyclisation. In Chapter III, an unprecedented investigation into the direct functionalization of pyrazines was described, leading to highly functionalized pyrazines in good yields and good regioselectivity. Finally, in Chapter IV, we have developed a method for the methylation and fluoromethylation of heteroarenes.
Advisors/Committee Members: Zard, Samir Z. (thesis director).
Subjects/Keywords: Chimie radicalaire; Xanthates; C-H Fonctionnalisation; Chimie radicalaire; Xanthates; C-H Functionalisation
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APA (6th Edition):
Huang, Q. (2017). Application of Xanthates to the Synthesis of Azaindanes and to the C-H Functionalization of Heteroaromatics : Application des Xanthates à la Synthèse des Azaindanes et à la Fonctionnalisation C-H des Hétéroaromatiques. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2017SACLX114
Chicago Manual of Style (16th Edition):
Huang, Qi. “Application of Xanthates to the Synthesis of Azaindanes and to the C-H Functionalization of Heteroaromatics : Application des Xanthates à la Synthèse des Azaindanes et à la Fonctionnalisation C-H des Hétéroaromatiques.” 2017. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 18, 2021.
http://www.theses.fr/2017SACLX114.
MLA Handbook (7th Edition):
Huang, Qi. “Application of Xanthates to the Synthesis of Azaindanes and to the C-H Functionalization of Heteroaromatics : Application des Xanthates à la Synthèse des Azaindanes et à la Fonctionnalisation C-H des Hétéroaromatiques.” 2017. Web. 18 Jan 2021.
Vancouver:
Huang Q. Application of Xanthates to the Synthesis of Azaindanes and to the C-H Functionalization of Heteroaromatics : Application des Xanthates à la Synthèse des Azaindanes et à la Fonctionnalisation C-H des Hétéroaromatiques. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2017. [cited 2021 Jan 18].
Available from: http://www.theses.fr/2017SACLX114.
Council of Science Editors:
Huang Q. Application of Xanthates to the Synthesis of Azaindanes and to the C-H Functionalization of Heteroaromatics : Application des Xanthates à la Synthèse des Azaindanes et à la Fonctionnalisation C-H des Hétéroaromatiques. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2017. Available from: http://www.theses.fr/2017SACLX114
2.
Daligaux, Pierre.
Conception et synthèse de nouvelles molécules à visée antileishmanienne. : Design and synthesis of news potent antileishmanial compounds.
Degree: Docteur es, Microbiologie, 2015, Université Paris-Saclay (ComUE)
URL: http://www.theses.fr/2015SACLS200
► Les leishmanioses sont un ensemble de maladies causées par un parasite du genre Leishmania. L'augmentation des résistances aux traitements actuellement disponibles conduit à la nécessité…
(more)
▼ Les leishmanioses sont un ensemble de maladies causées par un parasite du genre Leishmania. L'augmentation des résistances aux traitements actuellement disponibles conduit à la nécessité de développer de nouvelles molécules antileishmaniennes. La GDP-MP, une enzyme indispensable à la virulence du parasite a été choisie comme cible thérapeutique. Dans la première partie de ce travail, des modèles de GDP-MP de L. donovani et de H. sapiens ont été construits par modélisation moléculaire en utilisant la construction par homologie de séquence puis la relaxation par dynamique moléculaire. La conception d'inhibiteurs assistée par l'évaluation par amarrage moléculaire de ces molécules a conduit à l'identification de nombreuses molécules potentiellement inhibitrices de la GDP-MP. Parmi ces molécules identifiées, certaines sont des analogues de GDP-Mannose présentant différents motifs de remplacement pour le pont pyrophosphate ainsi que pour la guanosine. Une autre classe de composés sont les analogues de GDP portant un motif bisphosphoré. Une étude méthodologique portant sur l'obtention de conjugués 1,4-triazoles par CuAAC sur des analogues de guanosine a été conduite, et a mis en évidence, l'efficacité de l'utilisation de nanoparticules de cuivre (I) formées in situ par réduction du sulfate de cuivre en solution aqueuse par de l'hydrate d'hydrazine pour la synthèse de ces composés. Cette méthode, en association avec la chimie des H-phosphonates, a permis, l'accès à une librairie de dérivés de GDP-Mannose. De cette manière, des analogues de guanosine et de quinoléines diversement substituées ont été synthétisés. Les composés obtenus ont été évalués sur les GDP-MP recombinantes ainsi que sur cultures de parasites. Certains des composés bisphosphonates présentent à la fois une bonne inhibition de la GDP-MP et une bonne activité antiparasitaire. Les expériences futures de cristallographie des protéines permettront d'élucider le mode de fixation de ces composés et d'orienter les pharmacomodulations futures des inhibiteurs identifiés.
Leishmaniasis is a set of disease caused by a parasite of the genus Leishmania. The increased resistance to currently available treatments led to the need to develop new antileishmanial compounds. GDP-MP, an enzyme essential for the virulence of the parasite was chosen as a therapeutic target. In the first part of this work, GDP-MP models L. donovani and H. sapiens were constructed by molecular modeling using the method of sequence homology and molecular dynamics relaxation. The evaluation of inhibitors by molecular docking has led to the identification of many potential inhibitors of GDP-MP. Among these molecules identified, some are GDP-Mannose analogs having different substitution patterns for the pyrophosphate bridge and for guanosine. Another class of compounds is the analogues of GDP wearing bisphosphorus moiety. A methodological study for the synthesis of guanosine conjugated 1,4-triazoles analogs by CuAAC was conducted and showed the effectiveness of the use of copper nanoparticles (I),…
Advisors/Committee Members: Cavé, Christian (thesis director).
Subjects/Keywords: Leishmaniose; Chimie médicinale; Modélisation moléculaire; Chimie « click »; H-Phosphonate; Antiparasitaire; Leishmaniasis; Medicinal chemistry; Molecular modeling; Click chemistry; H-Phosphonate; Antiparasitic
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APA ·
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APA (6th Edition):
Daligaux, P. (2015). Conception et synthèse de nouvelles molécules à visée antileishmanienne. : Design and synthesis of news potent antileishmanial compounds. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2015SACLS200
Chicago Manual of Style (16th Edition):
Daligaux, Pierre. “Conception et synthèse de nouvelles molécules à visée antileishmanienne. : Design and synthesis of news potent antileishmanial compounds.” 2015. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 18, 2021.
http://www.theses.fr/2015SACLS200.
MLA Handbook (7th Edition):
Daligaux, Pierre. “Conception et synthèse de nouvelles molécules à visée antileishmanienne. : Design and synthesis of news potent antileishmanial compounds.” 2015. Web. 18 Jan 2021.
Vancouver:
Daligaux P. Conception et synthèse de nouvelles molécules à visée antileishmanienne. : Design and synthesis of news potent antileishmanial compounds. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2015. [cited 2021 Jan 18].
Available from: http://www.theses.fr/2015SACLS200.
Council of Science Editors:
Daligaux P. Conception et synthèse de nouvelles molécules à visée antileishmanienne. : Design and synthesis of news potent antileishmanial compounds. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2015. Available from: http://www.theses.fr/2015SACLS200
University of Huddersfield
3.
Samuels, Robert.
Values of Engagement: Exploring Digital Media through Generation and Neoliberalism.
Degree: 2018, University of Huddersfield
URL: http://eprints.hud.ac.uk/id/eprint/34813/1/Samuels%20THESIS.pdf
► Within existing literature (Fiske, 1992; Jenkins, 2006; Bruns, 2007; 2008a) digital media engagement is often understood through audience productivity, privileging productive fans over unproductive others,…
(more)
▼ Within existing literature (Fiske, 1992; Jenkins, 2006; Bruns, 2007; 2008a) digital media engagement is often understood through audience productivity, privileging productive fans over unproductive others, and limiting our understanding of how and why users engage with digital media. In my study, I complicate this discourse by exploring the multi-modal value of digital engagement within an original and empirically-grounded ‘cascade’ model. Adopting a qualitative interview study, I collected in-depth interviews from 34 participants, aged 20-30, exploring my respondents’ performances of their engagement through generation and neoliberalism.
Theoretically, I argue for the plurality of value and engagement, which my participants negotiate across varying contexts (Boltanski and Thévenot, 1987/2006) through my cascade model, which aligns four original modes of engagement: fan-like, guarded, routinised, and restricted, with distinct forms of value: community, personal, habitual, and reflective. Participants enter the model via one of three levels, fluidly hybridising value and engagement in a variety of differentiated ways. Through this analysis, I argue that neoliberalism (Rose, 1999; McGuigan, 2014) emerged as a key contextual factor framing the value of participants’ engagement, with the position via which respondents enter, and thus negotiate, the cascade model relating to their specific neoliberal dispositions towards ‘right’ and ‘wrong’ ‘self-branding’ (Marwick, 2013).
By aligning participants’ neoliberal dispositions with digital cultural capital (Bourdieu, 1993; Rojas et al, 2000), I also critically interrogate the ‘digital natives’ concept (Prensky, 2001; 2012; Palfrey and Gasser, 2008), arguing that the varying levels of capital and differing engagement modes in my data challenge this monolithic discourse which assumes a shared generational digital habitus. Within my innovative model, the value of engagement is not only multi-modal, but inherently fluid, with my approach complicating discourse in this field beyond existing notions of productivity, without arguing for audience productivity as normative or positing a binary of productive and unproductive engagement. This study, therefore, is vital to furthering our understanding of how and why users engage with digital media (Light, 2014; Park, 2017; Bury,2018), and the value of this practice within neoliberal digital media ‘worlds’ (Boltanski and Thévenot, 1987/2006, p. 215).
Subjects/Keywords: H Social Sciences (General); T Technology (General)
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Record Details
Similar Records
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❌
APA ·
Chicago ·
MLA ·
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CSE |
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Manager
APA (6th Edition):
Samuels, R. (2018). Values of Engagement: Exploring Digital Media through Generation and Neoliberalism. (Doctoral Dissertation). University of Huddersfield. Retrieved from http://eprints.hud.ac.uk/id/eprint/34813/1/Samuels%20THESIS.pdf
Chicago Manual of Style (16th Edition):
Samuels, Robert. “Values of Engagement: Exploring Digital Media through Generation and Neoliberalism.” 2018. Doctoral Dissertation, University of Huddersfield. Accessed January 18, 2021.
http://eprints.hud.ac.uk/id/eprint/34813/1/Samuels%20THESIS.pdf.
MLA Handbook (7th Edition):
Samuels, Robert. “Values of Engagement: Exploring Digital Media through Generation and Neoliberalism.” 2018. Web. 18 Jan 2021.
Vancouver:
Samuels R. Values of Engagement: Exploring Digital Media through Generation and Neoliberalism. [Internet] [Doctoral dissertation]. University of Huddersfield; 2018. [cited 2021 Jan 18].
Available from: http://eprints.hud.ac.uk/id/eprint/34813/1/Samuels%20THESIS.pdf.
Council of Science Editors:
Samuels R. Values of Engagement: Exploring Digital Media through Generation and Neoliberalism. [Doctoral Dissertation]. University of Huddersfield; 2018. Available from: http://eprints.hud.ac.uk/id/eprint/34813/1/Samuels%20THESIS.pdf
University of Huddersfield
4.
Stone, Tobias.
AN EXAMINATION OF STARTUP ACCELERATORS USING SOCIAL NETWORK THEORY.
Degree: 2018, University of Huddersfield
URL: http://eprints.hud.ac.uk/id/eprint/34731/1/Stone%20THESIS.pdf
► This thesis combines a literature review and a case study in order to examine startup accelerators as social networks. The literature review looks at two…
(more)
▼ This thesis combines a literature review and a case study in order to examine startup accelerators as social networks. The literature review looks at two distinct bodies of research; the first on Social Network Theory, in order to create a framework within which to describe an accelerator as a social network, the second on startup accelerators in order to understand their structure and evolution as business support programs. The case study uses EyeFocus Accelerator, founded by this researcher, to test some of the ideas formulated from the literature.
The literature demonstrates that accelerators are social networks, and the dynamics between the different actors in those networks can be explained and defined using the vocabulary and concepts of Social Network Theory. This describes the structure of the accelerator network, and how such a network is able to reward people with Social Capital, which is observed in this thesis to be the currency of accelerators.
Consequently, the unique nature of the research in this thesis is to describe accelerators using the language and concepts of Social Network Theory, providing new insights into how and why accelerators work.
This understanding identifies that value in accelerators lies in their ability to facilitate the flow of non-redundant information, and to provide early access to this information. Creating this value also enables accelerators to withdraw access to that value as a threat of sanction against bad actors.
Other aspects of the social network structure and behaviour of accelerators are examined, including the tendency of weak ties and non-redundancy of information to decay over time, suggesting that this may explain the typical fixed term of most accelerators.
Combined, this theory leads to an accelerator being described as a dynamic social network with a high level of closure at the core, set within a weak network architecture, with many weak ties, and consequently many bridging ties. It is policed using link reciprocity, and its currency is Social Capital. The skill used to operate in this network involves having complex role and status sets.
Subjects/Keywords: H Social Sciences (General); T Technology (General)
Record Details
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Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Stone, T. (2018). AN EXAMINATION OF STARTUP ACCELERATORS USING SOCIAL NETWORK THEORY. (Doctoral Dissertation). University of Huddersfield. Retrieved from http://eprints.hud.ac.uk/id/eprint/34731/1/Stone%20THESIS.pdf
Chicago Manual of Style (16th Edition):
Stone, Tobias. “AN EXAMINATION OF STARTUP ACCELERATORS USING SOCIAL NETWORK THEORY.” 2018. Doctoral Dissertation, University of Huddersfield. Accessed January 18, 2021.
http://eprints.hud.ac.uk/id/eprint/34731/1/Stone%20THESIS.pdf.
MLA Handbook (7th Edition):
Stone, Tobias. “AN EXAMINATION OF STARTUP ACCELERATORS USING SOCIAL NETWORK THEORY.” 2018. Web. 18 Jan 2021.
Vancouver:
Stone T. AN EXAMINATION OF STARTUP ACCELERATORS USING SOCIAL NETWORK THEORY. [Internet] [Doctoral dissertation]. University of Huddersfield; 2018. [cited 2021 Jan 18].
Available from: http://eprints.hud.ac.uk/id/eprint/34731/1/Stone%20THESIS.pdf.
Council of Science Editors:
Stone T. AN EXAMINATION OF STARTUP ACCELERATORS USING SOCIAL NETWORK THEORY. [Doctoral Dissertation]. University of Huddersfield; 2018. Available from: http://eprints.hud.ac.uk/id/eprint/34731/1/Stone%20THESIS.pdf
University of Huddersfield
5.
Kenny, Megan.
WHO’S FOLLOWING YOU? CYBER VIOLENCE ON SOCIAL MEDIA.
Degree: 2018, University of Huddersfield
URL: http://eprints.hud.ac.uk/id/eprint/34871/1/Kenny%20THESIS.pdf
► Social media use has become an integral part of daily life. Within these increasingly influential online communities, a proportion of users are subject to negative…
(more)
▼ Social media use has become an integral part of daily life. Within these increasingly influential online communities, a proportion of users are subject to negative online contact in a phenomenon labelled cyberviolence. Cyberviolence is defined as harm delivered by electronic means to a person or people who perceive this contact as negative.A review of existing literature revealed that, despite reliance on distinct offline definitions, all behaviours explored could be classified according to three key themes: sexual, threatening and humiliating cyberviolence. To assess the prevalence of these forms of cyberviolence across social media, 370 participants completed an online survey that featured items relating to victimisation and perpetration, as well as a number of well-established personality measures. These measures explored key traits and models of personality including the Big Five model to assess the potential role of an individual’s personality in their engagement in cyberviolence. The results of this thesis suggest that differences exist between those involved in cyberviolence and those who do not engage in cyberviolence on certain key personality traits including psychopathy and narcissism. Models of cybervictimisation, perpetration and a hybrid of cybervictimisation/perpetration revealed that these traits explained approximately ten percent of the variance in cyberviolence indicating that other factors, besides individual personalities, may have more influence over engagement in and/or experience of these behaviours. Overall findings suggest that there is little to demarcate those involved in cyberviolence, as victims or perpetrators, leading to the conclusion that this is not a niche area of deviance, but may be a mainstream side effect of social media use. The implications of these findings are discussed.
Subjects/Keywords: H Social Sciences (General); T Technology (General)
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Record Details
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APA (6th Edition):
Kenny, M. (2018). WHO’S FOLLOWING YOU? CYBER VIOLENCE ON SOCIAL MEDIA. (Thesis). University of Huddersfield. Retrieved from http://eprints.hud.ac.uk/id/eprint/34871/1/Kenny%20THESIS.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kenny, Megan. “WHO’S FOLLOWING YOU? CYBER VIOLENCE ON SOCIAL MEDIA.” 2018. Thesis, University of Huddersfield. Accessed January 18, 2021.
http://eprints.hud.ac.uk/id/eprint/34871/1/Kenny%20THESIS.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kenny, Megan. “WHO’S FOLLOWING YOU? CYBER VIOLENCE ON SOCIAL MEDIA.” 2018. Web. 18 Jan 2021.
Vancouver:
Kenny M. WHO’S FOLLOWING YOU? CYBER VIOLENCE ON SOCIAL MEDIA. [Internet] [Thesis]. University of Huddersfield; 2018. [cited 2021 Jan 18].
Available from: http://eprints.hud.ac.uk/id/eprint/34871/1/Kenny%20THESIS.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kenny M. WHO’S FOLLOWING YOU? CYBER VIOLENCE ON SOCIAL MEDIA. [Thesis]. University of Huddersfield; 2018. Available from: http://eprints.hud.ac.uk/id/eprint/34871/1/Kenny%20THESIS.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
6.
Ledda, Marcelo Eduardo.
GRIDTICS – Bases para la constitución de una empresa de desarrollo de software embebido.
Degree: Instituto de Ciencias de la Administración, 2011, Universidad Católica de Córdoba
URL: http://pa.bibdigital.uccor.edu.ar/68/
► GridTICs es un grupo de investigación, desarrollo e ingeniería de proyectos relacionado a las tecnologías de información y comunicación, perteneciente a la Universidad Tecnológica Nacional…
(more)
▼ GridTICs es un grupo de investigación, desarrollo e ingeniería de proyectos relacionado a las tecnologías de información y comunicación, perteneciente a la Universidad Tecnológica Nacional Facultad Regional Mendoza. Se propone desarrollar empresarialmente su área de sistemas embebidos.
El estudio ha pretendido sentar las bases para el desarrollo de un negocio, principalmente de software, orientado al sector de sistemas embebidos.
Para la confección del trabajo se consultaron fuentes primarias como integrantes de GridTICs y actores clave en la Universidad y empresarios del negocio de software. Como complemento se examinaron textos, revistas, documentos, prensa, y principalmente, sitios de internet correspondientes a empresas y cámaras empresariales referentes del sector.
Se logró conocer que la productividad de la industria no es capaz de mantenerse al nivel de las necesidades actuales. El sector presenta un atractivo "estructural" y “transversal”, a partir de las demandas que presentan todos los sectores de la economía.
Indicadores como "Grado de aplicabilidad de los Sistemas Embebidos en cualquier ámbito sectorial" no dejan de crecer. Los Sistemas Embebidos continuarán revolucionando los sectores de energía, transporte, comunicaciones y automatización industrial y de servicios, entre otros.
En cuanto a las bases para llevar a cabo adecuadas estrategias de negocio, es necesario realizar un adecuado estudio de mercado, dado lo amplio del sector, concentrando el análisis en aquellos entornos que estén al alcance de las posibilidades y competencias, así como de infraestructura disponible.
En cuanto al tipo de trabajos a realizar se pudo observar que no es muy conveniente iniciar actividades en: desarrollo de producto, servicios orientados a aplicaciones que impliquen una alta frecuencia (eléctrica) de operación, o un complejo y costoso equipamiento, solo para la etapa de pruebas. Desde el punto de vista del tipo de cliente, no se debería abordar mercados de empresas finales, si no empresas proveedoras de soluciones embebidas.
Finalizando se observa que se presentan importantes desafíos a sortear, en materia de recursos humanos, financiamiento y habilidades de gestión empresaria en general, propios del salto estratégico planteado
Subjects/Keywords: H Ciencias Sociales (General); T Tecnología (General)
Record Details
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APA ·
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MLA ·
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CSE |
Export
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APA (6th Edition):
Ledda, M. E. (2011). GRIDTICS – Bases para la constitución de una empresa de desarrollo de software embebido. (Masters Thesis). Universidad Católica de Córdoba. Retrieved from http://pa.bibdigital.uccor.edu.ar/68/
Chicago Manual of Style (16th Edition):
Ledda, Marcelo Eduardo. “GRIDTICS – Bases para la constitución de una empresa de desarrollo de software embebido.” 2011. Masters Thesis, Universidad Católica de Córdoba. Accessed January 18, 2021.
http://pa.bibdigital.uccor.edu.ar/68/.
MLA Handbook (7th Edition):
Ledda, Marcelo Eduardo. “GRIDTICS – Bases para la constitución de una empresa de desarrollo de software embebido.” 2011. Web. 18 Jan 2021.
Vancouver:
Ledda ME. GRIDTICS – Bases para la constitución de una empresa de desarrollo de software embebido. [Internet] [Masters thesis]. Universidad Católica de Córdoba; 2011. [cited 2021 Jan 18].
Available from: http://pa.bibdigital.uccor.edu.ar/68/.
Council of Science Editors:
Ledda ME. GRIDTICS – Bases para la constitución de una empresa de desarrollo de software embebido. [Masters Thesis]. Universidad Católica de Córdoba; 2011. Available from: http://pa.bibdigital.uccor.edu.ar/68/
University of Huddersfield
7.
Samuels, Robert.
Values of engagement : exploring digital media through generation and neoliberalism.
Degree: PhD, 2018, University of Huddersfield
URL: http://eprints.hud.ac.uk/id/eprint/34813/
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.769062
► Within existing literature (Fiske, 1992; Jenkins, 2006; Bruns, 2007; 2008a) digital media engagement is often understood through audience productivity, privileging productive fans over unproductive others,…
(more)
▼ Within existing literature (Fiske, 1992; Jenkins, 2006; Bruns, 2007; 2008a) digital media engagement is often understood through audience productivity, privileging productive fans over unproductive others, and limiting our understanding of how and why users engage with digital media. In my study, I complicate this discourse by exploring the multi-modal value of digital engagement within an original and empirically-grounded 'cascade' model. Adopting a qualitative interview study, I collected in-depth interviews from 34 participants, aged 20-30, exploring my respondents' performances of their engagement through generation and neoliberalism. Theoretically, I argue for the plurality of value and engagement, which my participants negotiate across varying contexts (Boltanski and Thévenot, 1987/2006) through my cascade model, which aligns four original modes of engagement: fan-like, guarded, routinised, and restricted, with distinct forms of value: community, personal, habitual, and reflective. Participants enter the model via one of three levels, fluidly hybridising value and engagement in a variety of differentiated ways. Through this analysis, I argue that neoliberalism (Rose, 1999; McGuigan, 2014) emerged as a key contextual factor framing the value of participants' engagement, with the position via which respondents enter, and thus negotiate, the cascade model relating to their specific neoliberal dispositions towards 'right' and 'wrong' 'self-branding' (Marwick, 2013). By aligning participants' neoliberal dispositions with digital cultural capital (Bourdieu, 1993; Rojas et al, 2000), I also critically interrogate the 'digital natives' concept (Prensky, 2001; 2012; Palfrey and Gasser, 2008), arguing that the varying levels of capital and differing engagement modes in my data challenge this monolithic discourse which assumes a shared generational digital habitus. Within my innovative model, the value of engagement is not only multi-modal, but inherently fluid, with my approach complicating discourse in this field beyond existing notions of productivity, without arguing for audience productivity as normative or positing a binary of productive and unproductive engagement. This study, therefore, is vital to furthering our understanding of how and why users engage with digital media (Light, 2014; Park, 2017; Bury,2018), and the value of this practice within neoliberal digital media 'worlds' (Boltanski and Thévenot, 1987/2006, p. 215).
Subjects/Keywords: H Social Sciences (General); T Technology (General)
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Share »
Record Details
Similar Records
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APA ·
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MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Samuels, R. (2018). Values of engagement : exploring digital media through generation and neoliberalism. (Doctoral Dissertation). University of Huddersfield. Retrieved from http://eprints.hud.ac.uk/id/eprint/34813/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.769062
Chicago Manual of Style (16th Edition):
Samuels, Robert. “Values of engagement : exploring digital media through generation and neoliberalism.” 2018. Doctoral Dissertation, University of Huddersfield. Accessed January 18, 2021.
http://eprints.hud.ac.uk/id/eprint/34813/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.769062.
MLA Handbook (7th Edition):
Samuels, Robert. “Values of engagement : exploring digital media through generation and neoliberalism.” 2018. Web. 18 Jan 2021.
Vancouver:
Samuels R. Values of engagement : exploring digital media through generation and neoliberalism. [Internet] [Doctoral dissertation]. University of Huddersfield; 2018. [cited 2021 Jan 18].
Available from: http://eprints.hud.ac.uk/id/eprint/34813/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.769062.
Council of Science Editors:
Samuels R. Values of engagement : exploring digital media through generation and neoliberalism. [Doctoral Dissertation]. University of Huddersfield; 2018. Available from: http://eprints.hud.ac.uk/id/eprint/34813/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.769062
University of Glasgow
8.
McCallum, Claire H.
Evaluating the impact of physical activity apps and wearables : an interdisciplinary investigation of research designs and methods.
Degree: PhD, 2019, University of Glasgow
URL: http://theses.gla.ac.uk/72978/
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775938
► Many smartphone apps and wearables have been developed to promote physical activity, however there are challenges in assessing their impact. Apps and wearables are rapidly…
(more)
▼ Many smartphone apps and wearables have been developed to promote physical activity, however there are challenges in assessing their impact. Apps and wearables are rapidly evolving technologies and thousands of physical activity apps that are publicly available on app stores remain unevaluated. There are concerns that traditional "gold standard" evaluation approaches, such as randomised control trials (RCTs), may be too slow to keep up with these, and produce effectiveness results that do not reflect real world settings. Rapid research designs (such as single case designs; SCDs) and innovative data collection methods (in-device sensors, device-generated user logs) have been proposed to improve research efficiency, yet preliminary evidence suggests they are not widely used in mHealth. This thesis reports three studies undertaken to investigate the use of rapid research designs and efficient methods for evaluating physical activity apps and wearables. First, a scoping review of the extent to which these approaches are employed by health and HCI researchers. Second, semi-structured interviews with researchers, data scientists and industry professionals to provide a deeper understanding of current evaluation practices. Third, the development and refinement of a methodological framework to support researchers in using SCDs in automated app store evaluations of physical activity apps. The findings suggest rapid research designs are not often employed in evaluations of physical activity and other health behaviour change apps. Researchers feel they face opportunity barriers (e.g. risking not being funded or published) and do not have the necessary skills (e.g. in using device generated user logs). Industry professionals appear to lack the motivation and time to evaluate effectiveness. Trade-offs were perceived between the measurement accuracy of in-device sensors and other factors such as user burden. Automated trials may speed up evaluations of physical activity apps and wearables, and the suggested data collection framework aims to support researchers in conducting rigorous effectiveness evaluations using app store- based SCDs. However, further work is needed to enable industry professionals to use the framework to evaluate their publicly-available apps.
Subjects/Keywords: H Social Sciences (General); T Technology (General)
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APA (6th Edition):
McCallum, C. H. (2019). Evaluating the impact of physical activity apps and wearables : an interdisciplinary investigation of research designs and methods. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/72978/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775938
Chicago Manual of Style (16th Edition):
McCallum, Claire H. “Evaluating the impact of physical activity apps and wearables : an interdisciplinary investigation of research designs and methods.” 2019. Doctoral Dissertation, University of Glasgow. Accessed January 18, 2021.
http://theses.gla.ac.uk/72978/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775938.
MLA Handbook (7th Edition):
McCallum, Claire H. “Evaluating the impact of physical activity apps and wearables : an interdisciplinary investigation of research designs and methods.” 2019. Web. 18 Jan 2021.
Vancouver:
McCallum CH. Evaluating the impact of physical activity apps and wearables : an interdisciplinary investigation of research designs and methods. [Internet] [Doctoral dissertation]. University of Glasgow; 2019. [cited 2021 Jan 18].
Available from: http://theses.gla.ac.uk/72978/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775938.
Council of Science Editors:
McCallum CH. Evaluating the impact of physical activity apps and wearables : an interdisciplinary investigation of research designs and methods. [Doctoral Dissertation]. University of Glasgow; 2019. Available from: http://theses.gla.ac.uk/72978/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775938
9.
Zeng, Qiulan.
Numerical Schemes for 1-D Two-Phase Flows.
Degree: 2017, University of Waterloo
URL: http://hdl.handle.net/10012/11890
► Modeling of two-phase flows with strong thermal and mechanical non-equilibrium ef- fects is important in engineering applications, such as the nuclear industry. The Advection Upstream…
(more)
▼ Modeling of two-phase flows with strong thermal and mechanical non-equilibrium ef-
fects is important in engineering applications, such as the nuclear industry. The Advection
Upstream Splitting Methods (AUSM-family schemes) are very popular due to their at-
tractive features for multiphase flow modeling. However, the computational efficiency of
collocated-grid-based AUSM-family schemes with explicit time integration are inferior due
to a number of issues. These include the odd-even decoupling of the collocated-grid-based
AUSM-family schemes for low-Mach-number flows, the non-conservative characteristic of
the two-phase governing equations, and the Courant-Friedrichs-Levy (CFL) number limi-
tation for the explicit time integration.
This thesis focuses on improving the accuracy and efficiency of calculation for all-Mach-
number two-phase flows. In order to achieve this objective, this thesis makes the first
attempt at using implicit staggered-grid-based AUSM-family (SG-AUSM-family) schemes.
This is a novel approach since most work in the publicly available literature solves multi-
phase compressible flow problems explicitly over collocated grids. In this thesis, a four-
equation generic two-fluid model is mainly considered. In addition, Newton’s method with
a numerical Jacobian matrix is employed to solve the implicitly discretized equations. The
benchmark test cases include Ransom’s water faucet, the oscillating manometer, the phase
separation, and the air-water shock tube problems.
In the first stage, after thorough mathematical analysis and numerical tests of various
explicit AUSM-family schemes on collocated grids, insight into the numerical dissipation
mechanism of the AUSM-family schemes was gained. This motivates the author to propose
a new scheme, namely, the staggered-grid-based AUSMFVS (SG-AUSMFVS) scheme, to
solve the stiff phase separation problem.
The second stage of the work is to examine the numerical accuracy and computational
efficiency of collocated-grid-based implicit AUSM-family schemes. Results demonstrate
that with certain time step size selections, the implicit AUSM-family schemes are superior
to their explicit counterparts, in terms of numerical accuracy and computational efficiency.
The third phase of the work is the application of the first-order SG-AUSM-family
schemes on the benchmark test cases. Results demonstrate the advantages of staggered-
grid-based AUSM + (SG-AUSM + ) and staggered-grid-based AUSMDV (SG-AUSMDV) over
their collocated-grid-based counterparts. With a staggered-grid arrangement, odd-even de-
coupling issues can be avoided. As a result, no additional diffusion terms are needed when
using SG-AUSM + and SG-AUSMDV schemes for low-Mach-number two-phase flows. Fur-
thermore, since the pressure and void fraction are already stored at the interface of the
velocity control volume, no interpolation of interfacial pressure is needed for the momen-
tum equations, thereby saving computational time. Finally, the SG-AUSM + scheme is
capable of producing accurate…
Subjects/Keywords: CFD; Multiphase flows; T-H codes; AUSM
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Manager
APA (6th Edition):
Zeng, Q. (2017). Numerical Schemes for 1-D Two-Phase Flows. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/11890
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Zeng, Qiulan. “Numerical Schemes for 1-D Two-Phase Flows.” 2017. Thesis, University of Waterloo. Accessed January 18, 2021.
http://hdl.handle.net/10012/11890.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Zeng, Qiulan. “Numerical Schemes for 1-D Two-Phase Flows.” 2017. Web. 18 Jan 2021.
Vancouver:
Zeng Q. Numerical Schemes for 1-D Two-Phase Flows. [Internet] [Thesis]. University of Waterloo; 2017. [cited 2021 Jan 18].
Available from: http://hdl.handle.net/10012/11890.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Zeng Q. Numerical Schemes for 1-D Two-Phase Flows. [Thesis]. University of Waterloo; 2017. Available from: http://hdl.handle.net/10012/11890
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
10.
Rekhroukh, Feriel.
Préparation de complexes d'or (III) alkyles pour de nouvelles réactivités : insertion migratoire et β-H élimination : New reactivities with gold (III) alkyl complexes : migratory insertion and beta hybride elimination.
Degree: Docteur es, Chimie moléculaire, 2016, Université Toulouse III – Paul Sabatier
URL: http://www.theses.fr/2016TOU30067
► Ce travail de thèse porte sur la chimie organométallique des composés d'or(III) et sur l'étude de nouvelles réactivités via une approche conjointe expérimentale et théorique.…
(more)
▼ Ce travail de thèse porte sur la chimie organométallique des composés d'or(III) et sur l'étude de nouvelles réactivités via une approche conjointe expérimentale et théorique. Nous avons préparé des complexes d'or(III) alkyles et aryles bien définis pour l'étude de deux étapes élémentaires inconnues à l'or: l'insertion migratoire d'oléfines et la B-H élimination. La première partie de ces travaux est dédiée à la préparation et au design de composés d'or(III) alkyles stables. Nous avons mis au point une stratégie directe et efficace pour accéder à des complexes d'or(III) alkyles cyclométallés bidentes (P,C) stables. Nous avons ensuite exploité la stabilité de ces complexes vis-à-vis de l'élimination réductrice pour étudier et caractériser des espèces cationiques d'or(III) [(P,C)AuR]+ avec des contres-ions plus ou moins labiles. La deuxième partie de ce manuscrit porte sur la réactivité de ces complexes d'or(III) avec des oléfines. A travers une étude de cas avec le norbornène nous avons pu mettre en évidence le premier exemple d'insertion migratoire d'oléfines dans une liaison AuIII-Me. Plusieurs intermédiaires clés de la réaction ont pu être caractérisés : un complexe pi, un complexe agostique et un complexe de syn insertion ; leur structure électronique a été analysée en détails. L'étude du mécanisme par DFT a confirmé un processus de coordination-insertion. Le processus d'insertion migratoire a pu être généralisé à d'autres oléfines comme l'éthylène. Dans une troisième partie, nous nous sommes intéressés à la stabilité des composés d'or(III) alkyles vis-à-vis d'une autre étape inconnue à l'or i.e la B-H élimination. Nous avons montré que ce processus se fait très facilement à partir de complexes (P,C) d'or(III) alkyles cationiques pour générer des composés d'or(III) hydrures et oléfines. L'analyse des produits de décomposition a notamment montré la capacité des intermédiaires hydrures à réinsérer des oléfines. Une séquence d'insertion d'éthylène, B-H élimination et réinsertion a pu être montrée par une combinaison d'analyses spectroscopiques et une étude DFT. Enfin, dans une dernière partie nous avons étudié le processus d'insertion migratoire d'alcènes et d'alcynes dans une liaison Au-Csp2. Nous avons pu constater une insertion beaucoup plus favorable que pour des liaisons Au-Csp3, ce qui a permis d'élargir le scope à d'autres oléfines. Nous avons également caractérisé des intermédiaires clefs d'or(III) pi arènes, inconnus, qui se sont montrés plus stables vis-à-vis du processus de B-H élimination.
The present work is an organometallic study concerning the chemistry of gold(III) complexes and their reactivity through both experimental and theoretical experiments. Well defined gold(III) alkyl and aryl complexes were prepared in the interest of studying two elementary steps unknown until now with gold: migratory insertion and ß-H elimination. The first part of this work is dedicated to the preparation and the design of stable gold (III) alkyl complexes. We developed a straightforward strategy to access stable…
Advisors/Committee Members: Bourissou, Didier (thesis director), Amgoune, Abderrahmane (thesis director).
Subjects/Keywords: Chimie de l'or; Insertion migratoire; Beta-H élimination; Oléfines; Complexe agostique
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APA ·
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MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rekhroukh, F. (2016). Préparation de complexes d'or (III) alkyles pour de nouvelles réactivités : insertion migratoire et β-H élimination : New reactivities with gold (III) alkyl complexes : migratory insertion and beta hybride elimination. (Doctoral Dissertation). Université Toulouse III – Paul Sabatier. Retrieved from http://www.theses.fr/2016TOU30067
Chicago Manual of Style (16th Edition):
Rekhroukh, Feriel. “Préparation de complexes d'or (III) alkyles pour de nouvelles réactivités : insertion migratoire et β-H élimination : New reactivities with gold (III) alkyl complexes : migratory insertion and beta hybride elimination.” 2016. Doctoral Dissertation, Université Toulouse III – Paul Sabatier. Accessed January 18, 2021.
http://www.theses.fr/2016TOU30067.
MLA Handbook (7th Edition):
Rekhroukh, Feriel. “Préparation de complexes d'or (III) alkyles pour de nouvelles réactivités : insertion migratoire et β-H élimination : New reactivities with gold (III) alkyl complexes : migratory insertion and beta hybride elimination.” 2016. Web. 18 Jan 2021.
Vancouver:
Rekhroukh F. Préparation de complexes d'or (III) alkyles pour de nouvelles réactivités : insertion migratoire et β-H élimination : New reactivities with gold (III) alkyl complexes : migratory insertion and beta hybride elimination. [Internet] [Doctoral dissertation]. Université Toulouse III – Paul Sabatier; 2016. [cited 2021 Jan 18].
Available from: http://www.theses.fr/2016TOU30067.
Council of Science Editors:
Rekhroukh F. Préparation de complexes d'or (III) alkyles pour de nouvelles réactivités : insertion migratoire et β-H élimination : New reactivities with gold (III) alkyl complexes : migratory insertion and beta hybride elimination. [Doctoral Dissertation]. Université Toulouse III – Paul Sabatier; 2016. Available from: http://www.theses.fr/2016TOU30067
11.
Baladi, Tom.
Autour du noyau imidazo[4,5-b]pyridine : inhibiteurs potentiels de la protéine kinase Tyro3 et fonctionnalisation directe de liaisons C – H. : The imidazo[4,5-b]pyridine scaffold : inhibitors of protein kinase Tyro3 and direct C - H functionalization.
Degree: Docteur es, Chimie, 2016, Université Paris-Saclay (ComUE)
URL: http://www.theses.fr/2016SACLS386
► Etant au quatrième rang des cancers les plus fréquents chez l'homme, le cancer de la vessie représente un enjeu médical important. Pourtant, à ce jour,…
(more)
▼ Etant au quatrième rang des cancers les plus fréquents chez l'homme, le cancer de la vessie représente un enjeu médical important. Pourtant, à ce jour, seuls des traitements chirurgicaux handicapants et/ou chimiothérapiques non spécifiques peuvent être envisagés. Le projet de thèse s'inscrit dans le cadre de la recherche de thérapies ciblées du cancer de la vessie en ayant pour objectif le blocage, au niveau moléculaire et de manière sélective, des voies de signalisation mises en œuvre par la tyrosine kinase Tyro3 au sein des cellules cancéreuses. La mise en évidence de la surexpression de ce récepteur membranaire dans la majorité des tumeurs de vessie et son rôle dans la survie des cellules cancéreuses ont en effet permis de valider Tyro3 comme cible thérapeutique pour ce type de cancers. Le projet peut se diviser en trois parties : le développement de nouvelles méthodologies de synthèse autour du motif imidazo[4,5-b]pyridine, la synthèse d'une librairie de candidats inhibiteurs en utilisant les méthodes mises au point et enfin l'étude des relations structure-activité vis-à-vis de la protéine kinase Tyro3.
Bladder cancer is a major medical issue, being the fourth most frequent cancer in men and treatable only with heavy surgery and/or broad-spectrum chemotherapy. This thesis project deals with the discovery of new targeted therapies of bladder cancer by blocking specifically, at a molecular scale in cancer cells, the signaling pathways in which protein kinase Tyro3 is involved. Indeed, its overexpression in most bladder cancers and the major part it plays in cancer cells survival have led to the validation of protein kinase Tyro3 as a therapeutic target for the treatment of bladder cancer. This thesis project can be divided into three main parts: the development of new synthetic methods around the imidazo[4,5-b]pyridine scaffold, the synthesis of a library of compounds using these methods and eventually the study of structure-activity relationships of these compounds versus Tyro3.
Advisors/Committee Members: Piguel, Sandrine (thesis director).
Subjects/Keywords: Chimie thérapeutique; Activation de liaisons C-H; Protéines kinases; Fonctionnalisation directe; Medicinal chemistry; C-H activation; Protein kinases; Direct functionalization
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Baladi, T. (2016). Autour du noyau imidazo[4,5-b]pyridine : inhibiteurs potentiels de la protéine kinase Tyro3 et fonctionnalisation directe de liaisons C – H. : The imidazo[4,5-b]pyridine scaffold : inhibitors of protein kinase Tyro3 and direct C - H functionalization. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2016SACLS386
Chicago Manual of Style (16th Edition):
Baladi, Tom. “Autour du noyau imidazo[4,5-b]pyridine : inhibiteurs potentiels de la protéine kinase Tyro3 et fonctionnalisation directe de liaisons C – H. : The imidazo[4,5-b]pyridine scaffold : inhibitors of protein kinase Tyro3 and direct C - H functionalization.” 2016. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 18, 2021.
http://www.theses.fr/2016SACLS386.
MLA Handbook (7th Edition):
Baladi, Tom. “Autour du noyau imidazo[4,5-b]pyridine : inhibiteurs potentiels de la protéine kinase Tyro3 et fonctionnalisation directe de liaisons C – H. : The imidazo[4,5-b]pyridine scaffold : inhibitors of protein kinase Tyro3 and direct C - H functionalization.” 2016. Web. 18 Jan 2021.
Vancouver:
Baladi T. Autour du noyau imidazo[4,5-b]pyridine : inhibiteurs potentiels de la protéine kinase Tyro3 et fonctionnalisation directe de liaisons C – H. : The imidazo[4,5-b]pyridine scaffold : inhibitors of protein kinase Tyro3 and direct C - H functionalization. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2016. [cited 2021 Jan 18].
Available from: http://www.theses.fr/2016SACLS386.
Council of Science Editors:
Baladi T. Autour du noyau imidazo[4,5-b]pyridine : inhibiteurs potentiels de la protéine kinase Tyro3 et fonctionnalisation directe de liaisons C – H. : The imidazo[4,5-b]pyridine scaffold : inhibitors of protein kinase Tyro3 and direct C - H functionalization. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2016. Available from: http://www.theses.fr/2016SACLS386
12.
Etienne, Marion.
Valorisation d'extraits de fleurs de Rhododendron groenlandicum pour des applications cosmétiques.
Degree: 2018, Université du Québec à Chicoutimi
URL: https://constellation.uqac.ca/4646/1/Etienne_uqac_0862N_10471.pdf
► Le Rhododendron groenlandicum, plus communément appelé thé du Labrador, était utilisé par les Amérindiens pour traiter diverses affections telles que la tuberculose, les problèmes rénaux,…
(more)
▼ Le Rhododendron groenlandicum, plus communément appelé thé du Labrador, était utilisé par les Amérindiens pour traiter diverses affections telles que la tuberculose, les problèmes rénaux, les brûlures, etc. Des études précédentes ont montré que les feuilles de R.
groenlandicum possédaient des propriétés antioxydante, anti-inflammatoire et cytotoxique envers les cellules cancéreuses. Cependant, les fleurs de R. groenlandicum ont été très peu étudiées auparavant. Le principal objectif de ce projet visait à étudier la composition chimique et l’activité biologique, des fleurs de R. groenlandicum. Pour atteindre cet objectif, plusieurs techniques de séparation ont été employées, d’abord la macération 50:50 MeOH:H2O, puis l’extraction liquide-liquide, suivie de colonnes DIAION et basse pression pour terminer par des HPLC préparatives. Cinq composés flavonoïdiques ont été isolés dans les extraits de fleurs de R. groenlandicum incluant la quercitrine, l’avicularine, l’afzeline, la catéchine et l’épicatéchine. Tous ces composés possèdent des propriétés antioxydantes avec des IC50 variant de 0,19 à 1,2 μg/ml. Il est intéressant de mentionner que l’avicularine, l’afzeline et la quercitrine sont rapportés pour la première fois dans R. groenlandicum. D’autre part, les huiles essentielles de fleurs et de feuilles de R. groenlandicum ont été préparées séparément afin d’étudier leur composition chimique respective. Le matériel végétal a donc été distillé par hydrodistillation et les huiles ont été analysées par chromatographie gazeuse sur GC-FID et GC-MS. Cette étude a révélé que les deux parties de la plante avaient une composition différente au niveau des composés et également de leurs proportions, tandis que les composés majoritaires de l’huile essentielle de fleurs sont le germacrene B (18,65%), l’α-selinene (18,53%) et le β-selinene (9,03%), ceux des feuilles sont l’α-selinene (13,99%), le germacrene B (13,20%) et l’α-pinene (8,59%). Ce projet a permis d’approfondir les connaissances phytochimiques sur R. groenlandicum en identifiant cinq composés présents dans ses fleurs ainsi que leurs activités biologiques.
Subjects/Keywords: Chimie
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APA ·
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APA (6th Edition):
Etienne, M. (2018). Valorisation d'extraits de fleurs de Rhododendron groenlandicum pour des applications cosmétiques. (Thesis). Université du Québec à Chicoutimi. Retrieved from https://constellation.uqac.ca/4646/1/Etienne_uqac_0862N_10471.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Etienne, Marion. “Valorisation d'extraits de fleurs de Rhododendron groenlandicum pour des applications cosmétiques.” 2018. Thesis, Université du Québec à Chicoutimi. Accessed January 18, 2021.
https://constellation.uqac.ca/4646/1/Etienne_uqac_0862N_10471.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Etienne, Marion. “Valorisation d'extraits de fleurs de Rhododendron groenlandicum pour des applications cosmétiques.” 2018. Web. 18 Jan 2021.
Vancouver:
Etienne M. Valorisation d'extraits de fleurs de Rhododendron groenlandicum pour des applications cosmétiques. [Internet] [Thesis]. Université du Québec à Chicoutimi; 2018. [cited 2021 Jan 18].
Available from: https://constellation.uqac.ca/4646/1/Etienne_uqac_0862N_10471.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Etienne M. Valorisation d'extraits de fleurs de Rhododendron groenlandicum pour des applications cosmétiques. [Thesis]. Université du Québec à Chicoutimi; 2018. Available from: https://constellation.uqac.ca/4646/1/Etienne_uqac_0862N_10471.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
13.
St-Gelais, Alexis.
Étude de la composition chimique et de l'activité biologique de Dirca palustris L.
Degree: 2014, Université du Québec à Chicoutimi
URL: https://constellation.uqac.ca/2800/1/Alexis_St-Gelais.pdf
► Aujourd’hui encore, près de la moitié des médicaments autorisés par les agences gouvernementales sont des molécules d’origine naturelle, ou des composés dérivés de celles-ci. Il…
(more)
▼ Aujourd’hui encore, près de la moitié des médicaments autorisés par les agences gouvernementales sont des molécules d’origine naturelle, ou des composés dérivés de celles-ci. Il existe encore un vaste potentiel de découverte de nouvelles molécules à intérêt thérapeutique chez les plantes, y compris dans le domaine du cancer où les besoins sont importants. L’arbuste nord-américain endémique Dirca palustris L. (dirca des marais), de la famille des Thymelaeaceae, a été utilisé par les Premières Nations du nord-est du continent pour traiter le cancer. Cette plante a donc été sélectionnée pour la recherche de têtes de série potentielles. Elle a fait l’objet de peu d’études phytochimiques, et l’activité cytotoxique in vitro importante de ses extraits n’a pas été expliquée à ce jour.
L’objectif principal de ce projet consistait à procéder au fractionnement bioguidé d’un extrait au dichlorométhane de l’écorce, du bois et des racines du dirca des marais, en vue d’isoler un ou plusieurs composés responsables de l’activité, particulièrement envers les cellules cancéreuses du poumon A-549. Plusieurs étapes de fractionnement chromatographique successives ont permis d’isoler 33 molécules appartenant à différentes familles chimiques. Les plus notables sont deux orthoesters diterpéniques de type daphnane, la huratoxine et la wikstrotoxine A; une famille de nouveaux métabolites secondaires soufrés, baptisés dirchromones, ainsi que la dircoxépine, de structure apparentée; et plusieurs nouveaux composés phénoliques, dont des alkyllignanes baptisés dircanols. On y retrouve également des lignanes, des flavones, un stilbène, une dicoumarine, une chromone, des phénylpropanoïdes et divers autres composés phénoliques. Tous les composés isolés ont été identifiés pour la première fois chez D. palustris. De ceux-ci, une vingtaine sont de nouvelles entités chimiques jamais rapportées dans la littérature.
Les daphnanes isolés permettent d’expliquer en partie la forte cytotoxicité des extraits (IC50 de 0,027 ?g/mL sur A-549 pour la fraction contenant les daphnanes). Les dirchromones y contribuent également par une activité cytotoxique variant selon la structure. Cette activité est sélective envers les cellules cancéreuses colorectales DLD-1. La plus importante activité est observée pour la structure de base de cette nouvelle classe de composés, la dirchromone, avec un IC50 de 1.0 ?M contre DLD-1 (contre 9 ?M et 10 ?M sur WS-1 et A-549), suivie de près par les dirchromones méthoxylées. Ces composés soufrés possèdent également une activité antibactérienne (MIC90 entre 7.8 et 62.5 ?M sur Staphylococcus aureus). Enfin, certains composés phénoliques isolés montrent également une activité cytotoxique.
Bref, ce projet a permis d’expliquer en partie l’activité cytotoxique de Dirca palustris L., en plus d’élargir les connaissances phytochimiques à son sujet. Il a notamment été l’occasion de rapporter pour la première fois des métabolites secondaires soufrés de structure originale chez les Thymelaeaceae.
Subjects/Keywords: Chimie
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APA (6th Edition):
St-Gelais, A. (2014). Étude de la composition chimique et de l'activité biologique de Dirca palustris L. (Thesis). Université du Québec à Chicoutimi. Retrieved from https://constellation.uqac.ca/2800/1/Alexis_St-Gelais.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
St-Gelais, Alexis. “Étude de la composition chimique et de l'activité biologique de Dirca palustris L.” 2014. Thesis, Université du Québec à Chicoutimi. Accessed January 18, 2021.
https://constellation.uqac.ca/2800/1/Alexis_St-Gelais.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
St-Gelais, Alexis. “Étude de la composition chimique et de l'activité biologique de Dirca palustris L.” 2014. Web. 18 Jan 2021.
Vancouver:
St-Gelais A. Étude de la composition chimique et de l'activité biologique de Dirca palustris L. [Internet] [Thesis]. Université du Québec à Chicoutimi; 2014. [cited 2021 Jan 18].
Available from: https://constellation.uqac.ca/2800/1/Alexis_St-Gelais.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
St-Gelais A. Étude de la composition chimique et de l'activité biologique de Dirca palustris L. [Thesis]. Université du Québec à Chicoutimi; 2014. Available from: https://constellation.uqac.ca/2800/1/Alexis_St-Gelais.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
14.
Boucher, Marie-Anne.
Caractérisation chimique et évaluation du potentiel antibactérien des huiles essentielles de Tussilago farfara (L.) et de Tanacetum vulgare (L.).
Degree: 2015, Université du Québec à Chicoutimi
URL: https://constellation.uqac.ca/3732/1/Boucher_uqac_0862N_10173.pdf
► Les résistances bactériennes aux antibiotiques sont de plus en plus nombreuses et ce phénomène s’avère une préoccupation très importante de la communauté médicale. L’utilisation des…
(more)
▼ Les résistances bactériennes aux antibiotiques sont de plus en plus nombreuses et ce phénomène s’avère une préoccupation très importante de la communauté médicale. L’utilisation des antibiotiques commerciaux comme promoteurs de croissance animale est l’une des causes probables. La substitution de ceux-ci par des produits naturels antibactériens, tels que les huiles essentielles, est une alternative intéressante. En effet, les huiles essentielles sont largement connues
pour leurs propriétés antimicrobiennes. Par contre, celles provenant de la forêt boréale ont rarement constitué un sujet d’étude. Les plantes qui la composent
forment donc une banque potentielle de nouveaux promoteurs de croissance. C'est dans ce but que le Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE) de l'Université du Québec à Chicoutimi a mis en place ce projet de recherche. Un criblage chimique et biologique a été effectué sur 17 plantes de la forêt boréale. Lors de ces travaux, ce sont Tussilago farfara (L.) et Tanacetum vulgare (L.) qui se sont démarqués pour leurs compositions chimiques particulières
et leurs activités biologiques. Ces deux huiles sont actives contre E. coli (T. farfara : MIC90 = 1511 ± 85 μg; T. vulgare : MIC90 = 331 ± 7 μg) et S. aureus (T. farfara : MIC90 = 170 ± 11 μg; T. vulgare : MIC90 = 228 ± 22 μg). Afin d'identifier les molécules principalement responsables de ces activités antibactériennes, les compositions chimiques ont été analysées par chromatographie gazeuse. L’huile essentielle de T. farfara est composée de molécules aliphatiques (42%), de monoterpènes (32%), de sesquiterpènes (10 %) et d’acides gras (5 %). Les composés majoritaires sont le 1-nonène (40 %), l’α-phellandrène (26 %), le p-cymène (7 %), le 1,10-undecadiène (4%), l’acide dodécanoïque (2 %) ainsi que le 1-decène (1 %). L’activité antibactérienne contre E. coli de cette huile essentielle est expliquée par l’acide dodécanoïque (6,6 ± 0,4 μg), le 1-decène (11 ± 1 μg), l’α-phellandrène (12 ± 1 μg), le β-caryophyllène (24 ± 1 μg), le (E)-cyclodecène (25,8 ± 0,9 μg), le p-cymène (26,3 ± 3,1 μg), le tricosane (31 ± 2 μg) et le tétracosane (35 ± 4 μg). Contre S. aureus se sont le
p-cymène et l’acide dodécanoïque, respectivement avec une MIC90 de 5,6 ± 0,2 μg et 6,0 ± 0,2 μg, qui sont, en partie, à l’origine de l’activité. Pour ce qui est de
T. vulgare, l’huile est plutôt composée de monoterpènes (89 %) et de sesquiterpènes (6 %). La majeure partie étant constituée de camphre (30 %), de bornéol (10 %), de
1,8-cinéole (10 %), de camphène (7 %) et de l’acétate de bornyle (5 %). Ce sont l’α-phellandrène (10 ± 1 μg), le β-caryophyllène (16 ± 1 μg), l’acétate de bornyle (21 ±
1 μg), l’oxide de caryophyllène (21 ± 1 μg), le camphre (22 ± 1 μg) ainsi que le pcymène (26 ± 3 μg) qui expliquent l’activité de cette huile contre E. coli. L’activité contre S. aureus est, quant à elle, expliquée par le p-cymène (5,6 ± 0,2 μg) et le camphre (26,3 ± 3,1 μg). En conclusion, nos résultats montrent que la forêt boréale est une source d’huiles…
Subjects/Keywords: Chimie
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APA ·
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APA (6th Edition):
Boucher, M. (2015). Caractérisation chimique et évaluation du potentiel antibactérien des huiles essentielles de Tussilago farfara (L.) et de Tanacetum vulgare (L.). (Thesis). Université du Québec à Chicoutimi. Retrieved from https://constellation.uqac.ca/3732/1/Boucher_uqac_0862N_10173.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Boucher, Marie-Anne. “Caractérisation chimique et évaluation du potentiel antibactérien des huiles essentielles de Tussilago farfara (L.) et de Tanacetum vulgare (L.).” 2015. Thesis, Université du Québec à Chicoutimi. Accessed January 18, 2021.
https://constellation.uqac.ca/3732/1/Boucher_uqac_0862N_10173.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Boucher, Marie-Anne. “Caractérisation chimique et évaluation du potentiel antibactérien des huiles essentielles de Tussilago farfara (L.) et de Tanacetum vulgare (L.).” 2015. Web. 18 Jan 2021.
Vancouver:
Boucher M. Caractérisation chimique et évaluation du potentiel antibactérien des huiles essentielles de Tussilago farfara (L.) et de Tanacetum vulgare (L.). [Internet] [Thesis]. Université du Québec à Chicoutimi; 2015. [cited 2021 Jan 18].
Available from: https://constellation.uqac.ca/3732/1/Boucher_uqac_0862N_10173.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Boucher M. Caractérisation chimique et évaluation du potentiel antibactérien des huiles essentielles de Tussilago farfara (L.) et de Tanacetum vulgare (L.). [Thesis]. Université du Québec à Chicoutimi; 2015. Available from: https://constellation.uqac.ca/3732/1/Boucher_uqac_0862N_10173.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
15.
Lavoie, Serge.
Isolement et caractérisation de principes actifs d'Abies balsamea et de Cornus canadensis.
Degree: 2015, Université du Québec à Chicoutimi
URL: https://constellation.uqac.ca/4002/1/Lavoie_uqac_0862D_10216.pdf
► Cette thèse présente les travaux réalisés dans le cadre du Doctorat en Science de l'environnement et qui ont pour thèmes l'étude phytochimique du sapin baumier…
(more)
▼ Cette thèse présente les travaux réalisés dans le cadre du Doctorat en Science de l'environnement et qui ont pour thèmes l'étude phytochimique du sapin baumier (Abies balsamea) et du quatre-temps (Cornus canadensis). Une revue de littérature étoffée sur le sapin baumier et le quatre-temps recensera d'abord l'ensemble des molécules et bioactivités décrites jusqu'à maintenant pour ces deux plantes.
Suivront ensuite les résultats obtenus sur le sapin baumier. La structure de deux tétraterpènes, rapidement déterminée grâce à la spectroscopie de résonance magnétique nucléaire et à la cristallographie par rayon X, sera d'abord présentée. Ensuite, de nouveaux triterpènes de la famille des lanostanes seront décrits. Ces résultats seront complétés par une proposition de structure pour plusieurs autres tétraterpènes qui n'ont pu faire l'objet d'analyse cristallographique.
La dernière partie sera constituée des travaux sur le quatre-temps. L'isolement des principes bioactifs de la plante sera d'abord présenté. Les composés isolés ont été caractérisés par résonance magnétique nucléaire et identifiés comme étant des tannins hydrolysables. Leurs activités antiherpétiques seront ensuite données. Ces résultats seront suivis par la synthèse et l'évaluation de l'activité biologique de composés inspirés de ces principes bioactifs. L'assignation des signaux de résonance magnétique nucléaire de ces molécules sera finalement présentée.
This thesis describes the research carried out as part of the PhD in Environment Science and deals with the phytochemistry of balsam fir (Abies balsamea) and of bunchberry (Cornus
canadensis). A complete literature review covering fir and dogwood will first enumerate the molecules and the bioactivities reported until now for these two plants.
Will then follow the results on balsam fir. First, the structure of two tetraterpenes, determined from nuclear magnetic resonance spectroscopy and X-ray crystallography, will be reported. Then, some new triterpenes from the lanostane family will be described. These results will be complemented with a proposal for the structure of several other tetraterpenes that could not be analyzed by crystallography.
The last part will deal with the bunchberry. First, the isolation of bioactive principles of the plant will be
reported. The isolated compounds where characterized by nuclear magnetic resonance and identified as hydrolyzable tannins. Their antiherpetic activity will then be demonstrated. These results will be followed by synthesis and evaluation of the bioactivities of molecules derived from those tannins. A complete assignment of the NMR signals for these molecules will ultimately be presented.
Subjects/Keywords: Chimie
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APA ·
Chicago ·
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CSE |
Export
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APA (6th Edition):
Lavoie, S. (2015). Isolement et caractérisation de principes actifs d'Abies balsamea et de Cornus canadensis. (Thesis). Université du Québec à Chicoutimi. Retrieved from https://constellation.uqac.ca/4002/1/Lavoie_uqac_0862D_10216.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lavoie, Serge. “Isolement et caractérisation de principes actifs d'Abies balsamea et de Cornus canadensis.” 2015. Thesis, Université du Québec à Chicoutimi. Accessed January 18, 2021.
https://constellation.uqac.ca/4002/1/Lavoie_uqac_0862D_10216.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lavoie, Serge. “Isolement et caractérisation de principes actifs d'Abies balsamea et de Cornus canadensis.” 2015. Web. 18 Jan 2021.
Vancouver:
Lavoie S. Isolement et caractérisation de principes actifs d'Abies balsamea et de Cornus canadensis. [Internet] [Thesis]. Université du Québec à Chicoutimi; 2015. [cited 2021 Jan 18].
Available from: https://constellation.uqac.ca/4002/1/Lavoie_uqac_0862D_10216.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lavoie S. Isolement et caractérisation de principes actifs d'Abies balsamea et de Cornus canadensis. [Thesis]. Université du Québec à Chicoutimi; 2015. Available from: https://constellation.uqac.ca/4002/1/Lavoie_uqac_0862D_10216.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
16.
Jost, Gilles.
Synthèse de dérivés glycosidiques de type ursane et évaluation de leur cytotoxicité.
Degree: 2017, Université du Québec à Chicoutimi
URL: https://constellation.uqac.ca/4526/1/Jost_uqac_0862N_10438.pdf
► Dans des études précédentes, plusieurs triterpènes ont montré des activités cytotoxiques et antitumorales intéressantes. Cependant, la faible hydrosolubilité de ces composés nuit considérablement à leur…
(more)
▼ Dans des études précédentes, plusieurs triterpènes ont montré des activités cytotoxiques et antitumorales intéressantes. Cependant, la faible hydrosolubilité de ces composés nuit considérablement à leur développement biopharmaceutique. Les travaux réalisés dans le cadre de ce mémoire visaient donc à synthétiser de nouveaux glycosides triterpéniques de type ursane plus soluble pour améliorer notamment leur cytotoxicité et possiblement leur sélectivité envers les cellules cancéreuses. Deux triterpènes, l’acide ursolique et l’uvaol ont été sélectionnés comme composés de départ auxquels ont été greffés différents sucres en position 3 et 28 incluant le D-, L-arabinose ; D-galactose, D- et L-fucose ; D- et L-lyxose, L-rhamnose ainsi que le D- et L-xylose. La fonction anomérique des différents sucres benzoylés a été déprotégée et activée par un groupement trichloroacétimidate (4 étapes). Les rendements obtenus varient entre 21 et 55%. La glycosylation des triterpènes ainsi que leur déprotection ont ensuite été réalisées. Deux monodesmosides ainsi que neuf bidesmosides ont été synthétisés avec succès avec un rendement se situant entre 38 et 72% (3 étapes). La cytotoxicité de l’acide ursolique, de l’uvaol et des dérivés glycosylés a été évaluée sur des lignées de cellules cancéreuses du poumon (A549) et du côlon (DLD-1) ainsi que sur une lignée de fibroblastes de peau humaine normale (WS1). Les résultats montrent que l’acide ursolique est cytotoxique contre les deux lignées de cellules cancéreuses ainsi que les cellules saines avec des IC50 entre 13.1 et 16 μM alors que l’uvaol est inactif avec une IC50 >200 μM. Pour les deux monodesmosides d’acide ursolique, le greffage d’un L-rhamnose en position 3 n’a pas d’impact significatif sur la cytotoxicité avec des IC50 variant entre 8.5 et 14 μM alors que le greffage d’un D-galactose inactive la molécule. D’autre part, les résultats montrent que la glycosylation des positions 3 et 28 de l’uvaol avec les différents sucres sont tous actifs (IC50 = 4.5 à 62 μM) à l’exception du dérivé greffé avec le L-xylose (IC50 >200 μM). L’ajout d’un L-rhamnose en position 3 et 28 a permis d’obtenir le dérivé le plus actif et sélectif de la série avec une IC50 de 4.5 μM envers les cellules cancéreuses du poumon, A549. Finalement, dans tous les cas, les bidesmosides d’uvaol constitués de sucres de la série D- sont plus cytotoxiques que ceux de la série L-.
Subjects/Keywords: Chimie
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jost, G. (2017). Synthèse de dérivés glycosidiques de type ursane et évaluation de leur cytotoxicité. (Thesis). Université du Québec à Chicoutimi. Retrieved from https://constellation.uqac.ca/4526/1/Jost_uqac_0862N_10438.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Jost, Gilles. “Synthèse de dérivés glycosidiques de type ursane et évaluation de leur cytotoxicité.” 2017. Thesis, Université du Québec à Chicoutimi. Accessed January 18, 2021.
https://constellation.uqac.ca/4526/1/Jost_uqac_0862N_10438.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Jost, Gilles. “Synthèse de dérivés glycosidiques de type ursane et évaluation de leur cytotoxicité.” 2017. Web. 18 Jan 2021.
Vancouver:
Jost G. Synthèse de dérivés glycosidiques de type ursane et évaluation de leur cytotoxicité. [Internet] [Thesis]. Université du Québec à Chicoutimi; 2017. [cited 2021 Jan 18].
Available from: https://constellation.uqac.ca/4526/1/Jost_uqac_0862N_10438.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Jost G. Synthèse de dérivés glycosidiques de type ursane et évaluation de leur cytotoxicité. [Thesis]. Université du Québec à Chicoutimi; 2017. Available from: https://constellation.uqac.ca/4526/1/Jost_uqac_0862N_10438.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
17.
Herailh, Christopher.
Hémisynthese de glycosides d’uvaol et évaluation de leur activité cytotoxique.
Degree: 2019, Université du Québec à Chicoutimi
URL: https://constellation.uqac.ca/5430/1/Herailh_uqac_0862N_10636.pdf
► Dans des études précédentes, plusieurs triterpènes ont montré des activités cytotoxiques intéressantes. Cependant, la faible hydrosolubilité de ces composés a ralenti leur développement biopharmaceutique. Des…
(more)
▼ Dans des études précédentes, plusieurs triterpènes ont montré des activités cytotoxiques intéressantes. Cependant, la faible hydrosolubilité de ces composés a ralenti leur développement biopharmaceutique. Des travaux réalisés par le laboratoire LASEVE ont montré que le greffage de sucres tel que le rhamnose augmente favorablement l’activité cytotoxique de plusieurs triterpènes comme l’acide bétulinique. Le principale objectif de ce mémoire visait à synthétiser de nouveaux glycosides triterpèniques de type ursane à partir de l’uvaol afin d’améliorer son activité cytotoxique. L’uvaol, a été synthétisé à partir d’un précurseur, l’acide ursolique. Par la suite, différents sucres ont été greffés sélectivement sur la position C-3 ou C-28. Les différents sucres qui ont été choisis sont le D-glucose, L et D-ribose, L-arabinose, L et D-xylose, L et D-lyxose, L et Drhamnose ainsi que le L et D-ribose. Les groupements hydroxyles des différents sucres ont été protégés avec des fonctions benzoyles. La position anomérique a ensuite été déprotégée et activée par un groupement trichloroacétimidate. Les rendements obtenus varient entre 21 % et 64 %. Ensuite, les glycosylations sélectives de l’uvaol en position C-3 ou C-28 ont permis d’obtenir, après la déprotection, une vingtaine de glycosides avec des rendements allant de 14 % à 86 %. La cytotoxicité des glycosides d’uvaol a été évaluée sur deux lignées de cellules cancéreuses humaines, A-549 (adénocarcinome pulmonaire), DLD-1 (adénocarcinome colorectal), ainsi que sur une lignée de fibroblastes de peau humaine normale WS-1. D’une part, l’uvaol est considéré inactif avec une IC50 supérieure à 100 μM. D’autre part, les résultats montrent que le greffage de sucres en position C-3 ou C-28 améliore significativement l’activité cytotoxique de l’uvaol avec des IC50 variant de 17 ± 4 μM à 78 ± 7 μM, à l’exception du dérivé D-glucose en C-28, (IC50 > 100 μM).
Subjects/Keywords: Chimie
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Herailh, C. (2019). Hémisynthese de glycosides d’uvaol et évaluation de leur activité cytotoxique. (Thesis). Université du Québec à Chicoutimi. Retrieved from https://constellation.uqac.ca/5430/1/Herailh_uqac_0862N_10636.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Herailh, Christopher. “Hémisynthese de glycosides d’uvaol et évaluation de leur activité cytotoxique.” 2019. Thesis, Université du Québec à Chicoutimi. Accessed January 18, 2021.
https://constellation.uqac.ca/5430/1/Herailh_uqac_0862N_10636.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Herailh, Christopher. “Hémisynthese de glycosides d’uvaol et évaluation de leur activité cytotoxique.” 2019. Web. 18 Jan 2021.
Vancouver:
Herailh C. Hémisynthese de glycosides d’uvaol et évaluation de leur activité cytotoxique. [Internet] [Thesis]. Université du Québec à Chicoutimi; 2019. [cited 2021 Jan 18].
Available from: https://constellation.uqac.ca/5430/1/Herailh_uqac_0862N_10636.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Herailh C. Hémisynthese de glycosides d’uvaol et évaluation de leur activité cytotoxique. [Thesis]. Université du Québec à Chicoutimi; 2019. Available from: https://constellation.uqac.ca/5430/1/Herailh_uqac_0862N_10636.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of New Mexico
18.
Brunsing, Ryan.
Induction of interleukin-10 within the T(H)17 effector population using the GPER agonist G-1.
Degree: Biomedical Sciences Graduate Program, 2013, University of New Mexico
URL: https://digitalrepository.unm.edu/biom_etds/115
► A critical mechanism in immune homeostasis is the ability to stop an ongoing inflammatory response once the inciting agent has been destroyed or neutralized. Failure…
(more)
▼ A critical mechanism in immune homeostasis is the ability to stop an ongoing inflammatory response once the inciting agent has been destroyed or neutralized. Failure to do so can lead to autoimmune disease. One mechanism the immune system utilizes to self regulate is the secretion of immunosuppressive cytokines. For example, the cytokine interleukin-10 (IL10) is a potent suppressor of numerous key immune cell populations. Among the cells that secrete IL10 are several subsets of the CD4+
T cell family. As CD4+
T cells are commonly found within diseased tissue in the setting of autoimmune disease, medications capable of inducing IL10 expression in local CD4+
T populations would be of great therapeutic interest. The small molecule G-1, an agonist directed against the membrane-bound estrogen receptor GPER, is known to attenuate the multiple sclerosis-like animal model EAE. However, its effects on CD4+
T cell populations were previously unknown. Using cultures of purified CD4+
T cells, we show that G-1 can elicit ERK-dependent expression of IL10. G-1 treated cultures secreted 3-fold more IL10, with no change in the proinflammatory cytokines IL17A, TNFα, and IFNy. Analysis of Foxp3 and RORyt expression demonstrated increased percentages of IL10+ cells in both the TH17 (RORyt+) and Foxp3+RORyt+ hybrid
T cell compartments. We also show that, in mice, in vivo treatment with G-1 leads to increased IL10 secretion from splenocytes. These results demonstrate that G-1 acts directly on CD4+
T cells, and to our knowledge provide the first example of a synthetic small molecule capable of eliciting IL10 expression in TH17 or hybrid
T cell populations. While G-1 treatment was not effective in a murine model of colitis, investigations of its effects in other
T cell-based disease models are warranted.
Advisors/Committee Members: Prossnitz, Eric, Prossnitz, Eric, Lipscomb, Mary, Lyons, C. Rick, Hjelle, Brian.
Subjects/Keywords: GPER; G-1; CD4+ T cells; interleukin-10; T(H)17 cells
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APA (6th Edition):
Brunsing, R. (2013). Induction of interleukin-10 within the T(H)17 effector population using the GPER agonist G-1. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/115
Chicago Manual of Style (16th Edition):
Brunsing, Ryan. “Induction of interleukin-10 within the T(H)17 effector population using the GPER agonist G-1.” 2013. Doctoral Dissertation, University of New Mexico. Accessed January 18, 2021.
https://digitalrepository.unm.edu/biom_etds/115.
MLA Handbook (7th Edition):
Brunsing, Ryan. “Induction of interleukin-10 within the T(H)17 effector population using the GPER agonist G-1.” 2013. Web. 18 Jan 2021.
Vancouver:
Brunsing R. Induction of interleukin-10 within the T(H)17 effector population using the GPER agonist G-1. [Internet] [Doctoral dissertation]. University of New Mexico; 2013. [cited 2021 Jan 18].
Available from: https://digitalrepository.unm.edu/biom_etds/115.
Council of Science Editors:
Brunsing R. Induction of interleukin-10 within the T(H)17 effector population using the GPER agonist G-1. [Doctoral Dissertation]. University of New Mexico; 2013. Available from: https://digitalrepository.unm.edu/biom_etds/115
University of Huddersfield
19.
Blackwell, Kane.
SOCIAL MEDIA, NEWS, AND YOUTHS: HOW YOUNG ADULTS CONSTRUCT AND ENGAGE NEWS CONTENT ON FACEBOOK.
Degree: 2018, University of Huddersfield
URL: http://eprints.hud.ac.uk/id/eprint/34820/1/Blackwell%20THESIS.pdf
► This research aims to investigate and critically assess how and to what extent young adults engage with ‘news’ on Facebook and what types of content…
(more)
▼ This research aims to investigate and critically assess how and to what extent young adults engage with ‘news’ on Facebook and what types of content they engage with. Eight young adults aged 22-30 years were interviewed along with the observation of their Facebook activity-logs over a 1-month period, from May 22nd to June 19th, during the 2017 UK general election and campaign period. The findings indicated overall that the participants used Facebook primarily as an intermediary for developing social context/understanding of news, as a means for commentary and personal expression; complementary to, prior and proceeding, their news engagement through additional media. The specifics of the participants’ Facebook engagement are outlined and discussed in detail.
Subjects/Keywords: H Social Sciences (General); JA Political science (General); T Technology (General)
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APA (6th Edition):
Blackwell, K. (2018). SOCIAL MEDIA, NEWS, AND YOUTHS: HOW YOUNG ADULTS CONSTRUCT AND ENGAGE NEWS CONTENT ON FACEBOOK. (Masters Thesis). University of Huddersfield. Retrieved from http://eprints.hud.ac.uk/id/eprint/34820/1/Blackwell%20THESIS.pdf
Chicago Manual of Style (16th Edition):
Blackwell, Kane. “SOCIAL MEDIA, NEWS, AND YOUTHS: HOW YOUNG ADULTS CONSTRUCT AND ENGAGE NEWS CONTENT ON FACEBOOK.” 2018. Masters Thesis, University of Huddersfield. Accessed January 18, 2021.
http://eprints.hud.ac.uk/id/eprint/34820/1/Blackwell%20THESIS.pdf.
MLA Handbook (7th Edition):
Blackwell, Kane. “SOCIAL MEDIA, NEWS, AND YOUTHS: HOW YOUNG ADULTS CONSTRUCT AND ENGAGE NEWS CONTENT ON FACEBOOK.” 2018. Web. 18 Jan 2021.
Vancouver:
Blackwell K. SOCIAL MEDIA, NEWS, AND YOUTHS: HOW YOUNG ADULTS CONSTRUCT AND ENGAGE NEWS CONTENT ON FACEBOOK. [Internet] [Masters thesis]. University of Huddersfield; 2018. [cited 2021 Jan 18].
Available from: http://eprints.hud.ac.uk/id/eprint/34820/1/Blackwell%20THESIS.pdf.
Council of Science Editors:
Blackwell K. SOCIAL MEDIA, NEWS, AND YOUTHS: HOW YOUNG ADULTS CONSTRUCT AND ENGAGE NEWS CONTENT ON FACEBOOK. [Masters Thesis]. University of Huddersfield; 2018. Available from: http://eprints.hud.ac.uk/id/eprint/34820/1/Blackwell%20THESIS.pdf
20.
Kyriakidou-Zacharoudiou, Avgousta.
Distributed development of large-scale distributed systems : the case of the particle physics grid.
Degree: PhD, 2011, London School of Economics and Political Science (University of London)
URL: http://etheses.lse.ac.uk/212/
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547866
► Developing a Grid within High Energy Physics for the Large Hadron Collider particle accelerator is characterised as a highly collaborative, distributed and dynamic systems development…
(more)
▼ Developing a Grid within High Energy Physics for the Large Hadron Collider particle accelerator is characterised as a highly collaborative, distributed and dynamic systems development effort. This research examines the way this distributed Grid is developed, deployed and provided as a service to the thousands of physicists analysing data from the Large Hadron Collider. The particle physics community has always been at the forefront of computing with a tradition of working in large distributed collaborations, therefore providing a "distinctive" case of distributed systems development practice. The focus of concern is the collaborative systems development practices employed by particle physicists in their attempt to develop a usable Grid. The research aims to offer lessons and practical recommendations to those involved in globally distributed systems development and to inform the information systems development literature. Global software development presents unaddressed challenges to organisations and it is argued that there is an urgent need for new systems development practices and strategies to be created that can facilitate and embrace the rapid changes of the environment and the complexities involved in such projects. The contribution of the study, therefore, is a framework of guidance towards engendering what the author defines as "Hybrid Experimental Agile Distributed Systems Development Communities" revealing a set of dynamic collaborative practices for those organisational contexts engaged in distributed systems development. The framework will allow them to reflect on their own practice and perhaps foster a similarly dynamic flexible community in order to manage their global software development effort. The research is in the form of an interpretative qualitative exploratory case study, which draws upon Activity Theory, and frames the Grid's distributed development activity as a complex overarching networked activity system influenced by the context, the community's tools, rules, norms, culture, history, past experiences, shared visions and collaborative way of working. Tensions and contradictions throughout the development of this Grid are explored and surfaced, with the research focusing on how these are resolved in order for the activity system to achieve stability. Such stability leads to the construction of new knowledge and learning and the formation of new systems development practices. In studying this, practices are considered as an emergent property linked to improvisation, bricolage and dynamic competences that unfold as large-scale projects evolve.
Subjects/Keywords: 539.7; H Social Sciences (General) : QC Physics : T Technology (General)
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APA ·
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MLA ·
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Export
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Manager
APA (6th Edition):
Kyriakidou-Zacharoudiou, A. (2011). Distributed development of large-scale distributed systems : the case of the particle physics grid. (Doctoral Dissertation). London School of Economics and Political Science (University of London). Retrieved from http://etheses.lse.ac.uk/212/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547866
Chicago Manual of Style (16th Edition):
Kyriakidou-Zacharoudiou, Avgousta. “Distributed development of large-scale distributed systems : the case of the particle physics grid.” 2011. Doctoral Dissertation, London School of Economics and Political Science (University of London). Accessed January 18, 2021.
http://etheses.lse.ac.uk/212/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547866.
MLA Handbook (7th Edition):
Kyriakidou-Zacharoudiou, Avgousta. “Distributed development of large-scale distributed systems : the case of the particle physics grid.” 2011. Web. 18 Jan 2021.
Vancouver:
Kyriakidou-Zacharoudiou A. Distributed development of large-scale distributed systems : the case of the particle physics grid. [Internet] [Doctoral dissertation]. London School of Economics and Political Science (University of London); 2011. [cited 2021 Jan 18].
Available from: http://etheses.lse.ac.uk/212/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547866.
Council of Science Editors:
Kyriakidou-Zacharoudiou A. Distributed development of large-scale distributed systems : the case of the particle physics grid. [Doctoral Dissertation]. London School of Economics and Political Science (University of London); 2011. Available from: http://etheses.lse.ac.uk/212/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547866
21.
Eaton, Benjamin David.
The dynamics of digital platform innovation : unfolding the paradox of control and generativity in Apple's iOS.
Degree: PhD, 2012, London School of Economics and Political Science (University of London)
URL: http://etheses.lse.ac.uk/463/
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.571040
► Mobile digital platforms provide an architectural basis for third party innovation of platform complements. Platform owners have property rights, enabling them to establish a boundary…
(more)
▼ Mobile digital platforms provide an architectural basis for third party innovation of platform complements. Platform owners have property rights, enabling them to establish a boundary of permissible innovation demarcating the permitted from the prohibited. This allows for the curation of complements, which provides a means of controlling for value creation. Consequently, platform innovationthe innovation of platform complements is occasionally refused by platform owners. When this occurs tensions may arise between the two parties over where the boundary of permissible innovation should lie. Tussles may break out, embodied in complex interactions, as each party attempts to get its way. Eventually an outcome is achieved, and a platform innovation is either allowed or prohibited. A body of platform innovation literature is emerging from fields including information systems. Whilst this literature considers many aspects of platform innovation, the dynamics concerning the control of the innovation of platform innovation complements is overlooked. This research attempts to address that gap. Its relevance to information systems concerns the digitalisation of platforms as systemsdigital infrastructures, which affects their capacity for innovation and regulation. This research uses the method of narrative networks to analyse 45 examples of contested platform innovation. This approach, informed by empirical data sourced from over 4500 blog entries, identifies patterned sequences of actions across the examples. These sequences describe how tension builds, how control is asserted, and how control is then resisted. A theory of formal managerial control is used to explain how mechanisms of control are applied by platform owners as well as how developers respond to control. The principle contribution of this research is to theory. It develops and presents a theory to describe and explain the dynamics of contested innovation of complements on curated digital platforms. In doing so, iIt challenges the understanding that the platform owner alone controls platform design rules and concerning which platform complements are allowed, and which are notthe boundary of permissible innovation. Furthermore, tThe study indicates opens up the possibility that the forces of digitalisation provide third parties with the power to affect influence platform architecture, but at the cost of additional means of being controlled.
Subjects/Keywords: 621.39; H Social Sciences (General); T Technology (General)
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Eaton, B. D. (2012). The dynamics of digital platform innovation : unfolding the paradox of control and generativity in Apple's iOS. (Doctoral Dissertation). London School of Economics and Political Science (University of London). Retrieved from http://etheses.lse.ac.uk/463/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.571040
Chicago Manual of Style (16th Edition):
Eaton, Benjamin David. “The dynamics of digital platform innovation : unfolding the paradox of control and generativity in Apple's iOS.” 2012. Doctoral Dissertation, London School of Economics and Political Science (University of London). Accessed January 18, 2021.
http://etheses.lse.ac.uk/463/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.571040.
MLA Handbook (7th Edition):
Eaton, Benjamin David. “The dynamics of digital platform innovation : unfolding the paradox of control and generativity in Apple's iOS.” 2012. Web. 18 Jan 2021.
Vancouver:
Eaton BD. The dynamics of digital platform innovation : unfolding the paradox of control and generativity in Apple's iOS. [Internet] [Doctoral dissertation]. London School of Economics and Political Science (University of London); 2012. [cited 2021 Jan 18].
Available from: http://etheses.lse.ac.uk/463/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.571040.
Council of Science Editors:
Eaton BD. The dynamics of digital platform innovation : unfolding the paradox of control and generativity in Apple's iOS. [Doctoral Dissertation]. London School of Economics and Political Science (University of London); 2012. Available from: http://etheses.lse.ac.uk/463/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.571040
22.
Kenny, Megan.
Who's following you? : cyber violence on social media.
Degree: PhD, 2018, University of Huddersfield
URL: http://eprints.hud.ac.uk/id/eprint/34871/
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.777814
► Social media use has become an integral part of daily life. Within these increasingly influential online communities, a proportion of users are subject to negative…
(more)
▼ Social media use has become an integral part of daily life. Within these increasingly influential online communities, a proportion of users are subject to negative online contact in a phenomenon labelled cyberviolence. Cyberviolence is defined as harm delivered by electronic means to a person or people who perceive this contact as negative. A review of existing literature revealed that, despite reliance on distinct offline definitions, all behaviours explored could be classified according to three key themes: sexual, threatening and humiliating cyberviolence. To assess the prevalence of these forms of cyberviolence across social media, 370 participants completed an online survey that featured items relating to victimisation and perpetration, as well as a number of well-established personality measures. These measures explored key traits and models of personality including the Big Five model to assess the potential role of an individual's personality in their engagement in cyberviolence. The results of this thesis suggest that differences exist between those involved in cyberviolence and those who do not engage in cyberviolence on certain key personality traits including psychopathy and narcissism. Models of cybervictimisation, perpetration and a hybrid of cybervictimisation/perpetration revealed that these traits explained approximately ten percent of the variance in cyberviolence indicating that other factors, besides individual personalities, may have more influence over engagement in and/or experience of these behaviours. Overall findings suggest that there is little to demarcate those involved in cyberviolence, as victims or perpetrators, leading to the conclusion that this is not a niche area of deviance, but may be a mainstream side effect of social media use. The implications of these findings are discussed.
Subjects/Keywords: 610; H Social Sciences (General); T Technology (General)
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APA ·
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Export
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Manager
APA (6th Edition):
Kenny, M. (2018). Who's following you? : cyber violence on social media. (Doctoral Dissertation). University of Huddersfield. Retrieved from http://eprints.hud.ac.uk/id/eprint/34871/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.777814
Chicago Manual of Style (16th Edition):
Kenny, Megan. “Who's following you? : cyber violence on social media.” 2018. Doctoral Dissertation, University of Huddersfield. Accessed January 18, 2021.
http://eprints.hud.ac.uk/id/eprint/34871/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.777814.
MLA Handbook (7th Edition):
Kenny, Megan. “Who's following you? : cyber violence on social media.” 2018. Web. 18 Jan 2021.
Vancouver:
Kenny M. Who's following you? : cyber violence on social media. [Internet] [Doctoral dissertation]. University of Huddersfield; 2018. [cited 2021 Jan 18].
Available from: http://eprints.hud.ac.uk/id/eprint/34871/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.777814.
Council of Science Editors:
Kenny M. Who's following you? : cyber violence on social media. [Doctoral Dissertation]. University of Huddersfield; 2018. Available from: http://eprints.hud.ac.uk/id/eprint/34871/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.777814
University of Glasgow
23.
Sotiropoulos, Panagiotis.
HRM innovation through technology in Greece : factors influencing the adoption, diffusion and exploitation of e-HRM and social media.
Degree: PhD, 2014, University of Glasgow
URL: http://theses.gla.ac.uk/5869/
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637654
► Although, electronic human resources management (e-HRM) and social media technologies appear to be increasingly used by companies to design and deliver their human resources management…
(more)
▼ Although, electronic human resources management (e-HRM) and social media technologies appear to be increasingly used by companies to design and deliver their human resources management (HRM) practices in order to face the demands of knowledge based economies, there is little empirical evidence concerning whether the absorption of these technologies leads to HRM innovation. To address this gap, this thesis examines the relationships between the absorptive capacity (ACAP) of organisations, e-HRM and social media technologies, and HRM innovation. Drawing mainly on the ACAP theory when paralleled with the innovation diffusion theory, a conceptual model was created from which a range of research hypotheses were deductively developed. These hypotheses were tested by surveying a sample of two hundred large companies that operate in Greece using varied statistical techniques such as parallel analysis, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), mediation analysis with bootstrapping, moderation analysis and Pearson’s correlation. To examine the reasons and the ways firms have absorbed e-HRM and social media in Greece, semi-structured interviews were conducted with the human resources (HR) directors of eight companies that had participated in the survey and had demonstrated high information communication technology (ICT) adoption. The results suggested that the ACAP of firms for e-HRM and social media has a significant effect on HRM innovation. The factors that determine ACAP and HRM innovation are: (1) the e-HRM and social media technologies, (2) the characteristics of these technologies, (3) prior knowledge and experience of firms, and (4) national culture. The adoption reasons included improvements in: data management, information security, confidentiality of data, HR service delivery, organisational culture, institutional isomorphism, and environmentally friendly e-HRM. In the case of multinational companies (MNCs): need for control by the headquarters, transparency and standardisation. Based on these findings, this thesis contributes a new framework of HRM innovation from organisational ACAP for e-HRM and social media and an alternative operationalisation of ACAP for technological knowledge around HRM. Implications for HRM, e-HRM and ACAP academics as well as HR practitioners and their companies are concluded along with the limitations of this thesis and future research suggestions.
Subjects/Keywords: 658.3009495; B Philosophy (General); H Social Sciences (General); T Technology (General)
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sotiropoulos, P. (2014). HRM innovation through technology in Greece : factors influencing the adoption, diffusion and exploitation of e-HRM and social media. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/5869/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637654
Chicago Manual of Style (16th Edition):
Sotiropoulos, Panagiotis. “HRM innovation through technology in Greece : factors influencing the adoption, diffusion and exploitation of e-HRM and social media.” 2014. Doctoral Dissertation, University of Glasgow. Accessed January 18, 2021.
http://theses.gla.ac.uk/5869/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637654.
MLA Handbook (7th Edition):
Sotiropoulos, Panagiotis. “HRM innovation through technology in Greece : factors influencing the adoption, diffusion and exploitation of e-HRM and social media.” 2014. Web. 18 Jan 2021.
Vancouver:
Sotiropoulos P. HRM innovation through technology in Greece : factors influencing the adoption, diffusion and exploitation of e-HRM and social media. [Internet] [Doctoral dissertation]. University of Glasgow; 2014. [cited 2021 Jan 18].
Available from: http://theses.gla.ac.uk/5869/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637654.
Council of Science Editors:
Sotiropoulos P. HRM innovation through technology in Greece : factors influencing the adoption, diffusion and exploitation of e-HRM and social media. [Doctoral Dissertation]. University of Glasgow; 2014. Available from: http://theses.gla.ac.uk/5869/ ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637654
University of Glasgow
24.
Munro, Fiona Robertson.
Renewable energy in Scotland: Extending the transition-periphery dynamics approach.
Degree: PhD, 2018, University of Glasgow
URL: http://theses.gla.ac.uk/8714/
► Scotland is being transformed as renewable energy resources are being exploited through new developments and infrastructure as part of an energy transition. Scotland has a…
(more)
▼ Scotland is being transformed as renewable energy resources are being exploited through new developments and infrastructure as part of an energy transition. Scotland has a significant amount of potential onshore and offshore renewable energy available for capture largely located in rural and isolated regions. Some of this potential renewable energy has been developed and contributes to the increasing amount of energy from low carbon sources in the UK, aiding in the UK reaching its greenhouse gas (GHG) emission targets.
This thesis responds to four research questions. The first proposes an analytical framework that incorporates the concept of resource peripheries and processes of peripheralization and centralization in the multilevel perspective (MLP) from the sociotechnical transitions literature. The second discusses the transition dynamics during the renewable energy transition in Scotland that are being shaped by a number of drivers including the shift to community ownership in Scotland and a range of policies, targets, and legislation. The third address the relationship dynamics between cores and peripheries created through processes of peripheralization that include relational, multi-dimensional processes that are also multi-scalar. The fourth discusses the uneven multi-scalar dynamics created as a transition occurs with processes of peripheralization and centralization creating resource peripheries as ‘transition-periphery dynamics’. By better understanding these dynamics and relationships during transitions the renewable energy transition can be better informed to deal with possible implications and ensure possible benefits are secured for a more sustainable future.
Subjects/Keywords: G Geography (General); H Social Sciences (General); T Technology (General)
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Munro, F. R. (2018). Renewable energy in Scotland: Extending the transition-periphery dynamics approach. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/8714/
Chicago Manual of Style (16th Edition):
Munro, Fiona Robertson. “Renewable energy in Scotland: Extending the transition-periphery dynamics approach.” 2018. Doctoral Dissertation, University of Glasgow. Accessed January 18, 2021.
http://theses.gla.ac.uk/8714/.
MLA Handbook (7th Edition):
Munro, Fiona Robertson. “Renewable energy in Scotland: Extending the transition-periphery dynamics approach.” 2018. Web. 18 Jan 2021.
Vancouver:
Munro FR. Renewable energy in Scotland: Extending the transition-periphery dynamics approach. [Internet] [Doctoral dissertation]. University of Glasgow; 2018. [cited 2021 Jan 18].
Available from: http://theses.gla.ac.uk/8714/.
Council of Science Editors:
Munro FR. Renewable energy in Scotland: Extending the transition-periphery dynamics approach. [Doctoral Dissertation]. University of Glasgow; 2018. Available from: http://theses.gla.ac.uk/8714/
University of Glasgow
25.
Sotiropoulos, Panagiotis.
HRΜ innovation through technology in Greece: factors influencing the adoption, diffusion and exploitation of e-HRM and social media.
Degree: PhD, 2014, University of Glasgow
URL: http://theses.gla.ac.uk/5869/
► Although, electronic human resources management (e-HRM) and social media technologies appear to be increasingly used by companies to design and deliver their human resources management…
(more)
▼ Although, electronic human resources management (e-HRM) and social media technologies appear to be increasingly used by companies to design and deliver their human resources management (HRM) practices in order to face the demands of knowledge based economies, there is little empirical evidence concerning whether the absorption of these technologies leads to HRM innovation. To address this gap, this thesis examines the relationships between the absorptive capacity (ACAP) of organisations, e-HRM and social media technologies, and HRM innovation. Drawing mainly on the ACAP theory when paralleled with the innovation diffusion theory, a conceptual model was created from which a range of research hypotheses were deductively developed. These hypotheses were tested by surveying a sample of two hundred large companies that operate in Greece using varied statistical techniques such as parallel analysis, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), mediation analysis with bootstrapping, moderation analysis and Pearson’s correlation. To examine the reasons and the ways firms have absorbed e-HRM and social media in Greece, semi-structured interviews were conducted with the human resources (HR) directors of eight companies that had participated in the survey and had demonstrated high information communication technology (ICT) adoption. The results suggested that the ACAP of firms for e-HRM and social media has a significant effect on HRM innovation. The factors that determine ACAP and HRM innovation are: (1) the e-HRM and social media technologies, (2) the characteristics of these technologies, (3) prior knowledge and experience of firms, and (4) national culture. The adoption reasons included improvements in: data management, information security, confidentiality of data, HR service delivery, organisational culture, institutional isomorphism, and environmentally friendly e-HRM. In the case of multinational companies (MNCs): need for control by the headquarters, transparency and standardisation. Based on these findings, this thesis contributes a new framework of HRM innovation from organisational ACAP for e-HRM and social media and an alternative operationalisation of ACAP for technological knowledge around HRM. Implications for HRM, e-HRM and ACAP academics as well as HR practitioners and their companies are concluded along with the limitations of this thesis and future research suggestions.
Subjects/Keywords: B Philosophy (General); H Social Sciences (General); T Technology (General)
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Share »
Record Details
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« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sotiropoulos, P. (2014). HRΜ innovation through technology in Greece: factors influencing the adoption, diffusion and exploitation of e-HRM and social media. (Doctoral Dissertation). University of Glasgow. Retrieved from http://theses.gla.ac.uk/5869/
Chicago Manual of Style (16th Edition):
Sotiropoulos, Panagiotis. “HRΜ innovation through technology in Greece: factors influencing the adoption, diffusion and exploitation of e-HRM and social media.” 2014. Doctoral Dissertation, University of Glasgow. Accessed January 18, 2021.
http://theses.gla.ac.uk/5869/.
MLA Handbook (7th Edition):
Sotiropoulos, Panagiotis. “HRΜ innovation through technology in Greece: factors influencing the adoption, diffusion and exploitation of e-HRM and social media.” 2014. Web. 18 Jan 2021.
Vancouver:
Sotiropoulos P. HRΜ innovation through technology in Greece: factors influencing the adoption, diffusion and exploitation of e-HRM and social media. [Internet] [Doctoral dissertation]. University of Glasgow; 2014. [cited 2021 Jan 18].
Available from: http://theses.gla.ac.uk/5869/.
Council of Science Editors:
Sotiropoulos P. HRΜ innovation through technology in Greece: factors influencing the adoption, diffusion and exploitation of e-HRM and social media. [Doctoral Dissertation]. University of Glasgow; 2014. Available from: http://theses.gla.ac.uk/5869/
The London School of Economics and Political Science (LSE)
26.
Kyriakidou-Zacharoudiou, Avgousta.
Distributed development of large-scale distributed systems: the case of the particle physics grid.
Degree: phd, 2011, The London School of Economics and Political Science (LSE)
URL: http://etheses.lse.ac.uk/212/
► Developing a Grid within High Energy Physics for the Large Hadron Collider particle accelerator is characterised as a highly collaborative, distributed and dynamic systems development…
(more)
▼ Developing a Grid within High Energy Physics for the Large Hadron Collider particle accelerator is characterised as a highly collaborative, distributed and dynamic systems development effort. This research examines the way this distributed Grid is developed, deployed and provided as a service to the thousands of physicists analysing data from the Large Hadron Collider. The particle physics community has always been at the forefront of computing with a tradition of working in large distributed collaborations, therefore providing a "distinctive" case of distributed systems development practice. The focus of concern is the collaborative systems development practices employed by particle physicists in their attempt to develop a usable Grid.
The research aims to offer lessons and practical recommendations to those involved in globally distributed systems development and to inform the information systems development literature. Global software development presents unaddressed challenges to organisations and it is argued that there is an urgent need for new systems development practices and strategies to be created that can facilitate and embrace the rapid changes of the environment and the complexities involved in such projects. The contribution of the study, therefore, is a framework of guidance towards engendering what the author defines as "Hybrid Experimental Agile Distributed Systems Development Communities" revealing a set of dynamic collaborative practices for those organisational contexts engaged in distributed systems development. The framework will allow them to reflect on their own practice and perhaps foster a similarly dynamic flexible community in order to manage their global software development effort.
The research is in the form of an interpretative qualitative exploratory case study, which draws upon Activity Theory, and frames the Grid's distributed development activity as a complex overarching networked activity system influenced by the context, the community's tools, rules, norms, culture, history, past experiences, shared visions and collaborative way of working. Tensions and contradictions throughout the development of this Grid are explored and surfaced, with the research focusing on how these are resolved in order for the activity system to achieve stability. Such stability leads to the construction of new knowledge and learning and the formation of new systems development practices. In studying this, practices are considered as an emergent property linked to improvisation, bricolage and dynamic competences that unfold as large-scale projects evolve.
Subjects/Keywords: H Social Sciences (General); QC Physics; T Technology (General)
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APA (6th Edition):
Kyriakidou-Zacharoudiou, A. (2011). Distributed development of large-scale distributed systems: the case of the particle physics grid. (Doctoral Dissertation). The London School of Economics and Political Science (LSE). Retrieved from http://etheses.lse.ac.uk/212/
Chicago Manual of Style (16th Edition):
Kyriakidou-Zacharoudiou, Avgousta. “Distributed development of large-scale distributed systems: the case of the particle physics grid.” 2011. Doctoral Dissertation, The London School of Economics and Political Science (LSE). Accessed January 18, 2021.
http://etheses.lse.ac.uk/212/.
MLA Handbook (7th Edition):
Kyriakidou-Zacharoudiou, Avgousta. “Distributed development of large-scale distributed systems: the case of the particle physics grid.” 2011. Web. 18 Jan 2021.
Vancouver:
Kyriakidou-Zacharoudiou A. Distributed development of large-scale distributed systems: the case of the particle physics grid. [Internet] [Doctoral dissertation]. The London School of Economics and Political Science (LSE); 2011. [cited 2021 Jan 18].
Available from: http://etheses.lse.ac.uk/212/.
Council of Science Editors:
Kyriakidou-Zacharoudiou A. Distributed development of large-scale distributed systems: the case of the particle physics grid. [Doctoral Dissertation]. The London School of Economics and Political Science (LSE); 2011. Available from: http://etheses.lse.ac.uk/212/
The London School of Economics and Political Science (LSE)
27.
Kaparoglu, Zeynep.
Matchmakers or tastemakers? Platformization of cultural intermediation & social media’s engines for ‘making up taste’.
Degree: phd, 2018, The London School of Economics and Political Science (LSE)
URL: http://etheses.lse.ac.uk/4194/
► There are long-standing practices and processes that have traditionally mediated between the processes of production and consumption of cultural content. The prominent instances of these…
(more)
▼ There are long-standing practices and processes that have traditionally mediated between the processes of production and consumption of cultural content. The prominent instances of these are: curating content by identifying and selecting cultural content in order to promote to a particular set of audiences; measuring audience behaviours to construct knowledge about their tastes; and guiding audiences through recommendations from cultural experts. These cultural intermediation processes are currently being transformed, and social media platforms play important roles in this transformation. However, their role is often attributed to the work of users and/or recommendation algorithms. Thus, the processes through which data about users’ taste are aggregated and made ready for algorithmic processing are largely neglected. This study takes this problematic as an important gap in our understanding of social media platforms’ role in the transformation of cultural intermediation. To address this gap, the notion of platformization is used as a theoretical lens to examine the role of users and algorithms as part of social media’s distinct data-based sociotechnical configuration, which is built on the so-called ‘platform-logic’. Based on a set of conceptual ideas and the findings derived through a single case study on a music discovery platform, this thesis developed a framework to explain ‘platformization of cultural intermediation’. This framework outlines how curation, guidance, and measurement processes are ‘plat-formed’ in the course of development and optimisation of a social media platform. This is the main contribution of the thesis. The study also contributes to the literature by developing the concept of social media’s engines for ‘making up taste’. This concept illuminates how social media operate as sociotechnical cultural intermediaries and participates in tastemaking in ways that acquire legitimacy from the long-standing trust in the objectivity of classification, quantification, and measurement processes.
Subjects/Keywords: H Social Sciences (General); T Technology (General); ZA4450 Databases
Record Details
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Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
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Manager
APA (6th Edition):
Kaparoglu, Z. (2018). Matchmakers or tastemakers? Platformization of cultural intermediation & social media’s engines for ‘making up taste’. (Doctoral Dissertation). The London School of Economics and Political Science (LSE). Retrieved from http://etheses.lse.ac.uk/4194/
Chicago Manual of Style (16th Edition):
Kaparoglu, Zeynep. “Matchmakers or tastemakers? Platformization of cultural intermediation & social media’s engines for ‘making up taste’.” 2018. Doctoral Dissertation, The London School of Economics and Political Science (LSE). Accessed January 18, 2021.
http://etheses.lse.ac.uk/4194/.
MLA Handbook (7th Edition):
Kaparoglu, Zeynep. “Matchmakers or tastemakers? Platformization of cultural intermediation & social media’s engines for ‘making up taste’.” 2018. Web. 18 Jan 2021.
Vancouver:
Kaparoglu Z. Matchmakers or tastemakers? Platformization of cultural intermediation & social media’s engines for ‘making up taste’. [Internet] [Doctoral dissertation]. The London School of Economics and Political Science (LSE); 2018. [cited 2021 Jan 18].
Available from: http://etheses.lse.ac.uk/4194/.
Council of Science Editors:
Kaparoglu Z. Matchmakers or tastemakers? Platformization of cultural intermediation & social media’s engines for ‘making up taste’. [Doctoral Dissertation]. The London School of Economics and Political Science (LSE); 2018. Available from: http://etheses.lse.ac.uk/4194/
University of Huddersfield
28.
Stone, Tobias.
An examination of startup accelerators using social network theory.
Degree: PhD, 2018, University of Huddersfield
URL: http://eprints.hud.ac.uk/id/eprint/34731/
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.762032
► This thesis combines a literature review and a case study in order to examine startup accelerators as social networks. The literature review looks at two…
(more)
▼ This thesis combines a literature review and a case study in order to examine startup accelerators as social networks. The literature review looks at two distinct bodies of research; the first on Social Network Theory, in order to create a framework within which to describe an accelerator as a social network, the second on startup accelerators in order to understand their structure and evolution as business support programs. The case study uses EyeFocus Accelerator, founded by this researcher, to test some of the ideas formulated from the literature. The literature demonstrates that accelerators are social networks, and the dynamics between the different actors in those networks can be explained and defined using the vocabulary and concepts of Social Network Theory. This describes the structure of the accelerator network, and how such a network is able to reward people with Social Capital, which is observed in this thesis to be the currency of accelerators. Consequently, the unique nature of the research in this thesis is to describe accelerators using the language and concepts of Social Network Theory, providing new insights into how and why accelerators work. This understanding identifies that value in accelerators lies in their ability to facilitate the flow of non-redundant information, and to provide early access to this information. Creating this value also enables accelerators to withdraw access to that value as a threat of sanction against bad actors. Other aspects of the social network structure and behaviour of accelerators are examined, including the tendency of weak ties and non-redundancy of information to decay over time, suggesting that this may explain the typical fixed term of most accelerators. Combined, this theory leads to an accelerator being described as a dynamic social network with a high level of closure at the core, set within a weak network architecture, with many weak ties, and consequently many bridging ties. It is policed using link reciprocity, and its currency is Social Capital. The skill used to operate in this network involves having complex role and status sets.
Subjects/Keywords: 302.3; H Social Sciences (General); T Technology (General)
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Stone, T. (2018). An examination of startup accelerators using social network theory. (Doctoral Dissertation). University of Huddersfield. Retrieved from http://eprints.hud.ac.uk/id/eprint/34731/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.762032
Chicago Manual of Style (16th Edition):
Stone, Tobias. “An examination of startup accelerators using social network theory.” 2018. Doctoral Dissertation, University of Huddersfield. Accessed January 18, 2021.
http://eprints.hud.ac.uk/id/eprint/34731/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.762032.
MLA Handbook (7th Edition):
Stone, Tobias. “An examination of startup accelerators using social network theory.” 2018. Web. 18 Jan 2021.
Vancouver:
Stone T. An examination of startup accelerators using social network theory. [Internet] [Doctoral dissertation]. University of Huddersfield; 2018. [cited 2021 Jan 18].
Available from: http://eprints.hud.ac.uk/id/eprint/34731/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.762032.
Council of Science Editors:
Stone T. An examination of startup accelerators using social network theory. [Doctoral Dissertation]. University of Huddersfield; 2018. Available from: http://eprints.hud.ac.uk/id/eprint/34731/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.762032
29.
Kaparoglu, Zeynep.
Matchmakers or tastemakers? : platformization of cultural intermediation & social media's engines for 'making up taste'.
Degree: PhD, 2018, London School of Economics and Political Science (University of London)
URL: http://etheses.lse.ac.uk/4194/
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.819636
► There are long-standing practices and processes that have traditionally mediated between the processes of production and consumption of cultural content. The prominent instances of these…
(more)
▼ There are long-standing practices and processes that have traditionally mediated between the processes of production and consumption of cultural content. The prominent instances of these are: curating content by identifying and selecting cultural content in order to promote to a particular set of audiences; measuring audience behaviours to construct knowledge about their tastes; and guiding audiences through recommendations from cultural experts. These cultural intermediation processes are currently being transformed, and social media platforms play important roles in this transformation. However, their role is often attributed to the work of users and/or recommendation algorithms. Thus, the processes through which data about users’ taste are aggregated and made ready for algorithmic processing are largely neglected. This study takes this problematic as an important gap in our understanding of social media platforms’ role in the transformation of cultural intermediation. To address this gap, the notion of platformization is used as a theoretical lens to examine the role of users and algorithms as part of social media’s distinct data-based sociotechnical configuration, which is built on the so-called ‘platform-logic’. Based on a set of conceptual ideas and the findings derived through a single case study on a music discovery platform, this thesis developed a framework to explain ‘platformization of cultural intermediation’. This framework outlines how curation, guidance, and measurement processes are ‘plat-formed’ in the course of development and optimisation of a social media platform. This is the main contribution of the thesis. The study also contributes to the literature by developing the concept of social media’s engines for ‘making up taste’. This concept illuminates how social media operate as sociotechnical cultural intermediaries and participates in tastemaking in ways that acquire legitimacy from the long-standing trust in the objectivity of classification, quantification, and measurement processes.
Subjects/Keywords: H Social Sciences (General); T Technology (General); ZA4450 Databases
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kaparoglu, Z. (2018). Matchmakers or tastemakers? : platformization of cultural intermediation & social media's engines for 'making up taste'. (Doctoral Dissertation). London School of Economics and Political Science (University of London). Retrieved from http://etheses.lse.ac.uk/4194/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.819636
Chicago Manual of Style (16th Edition):
Kaparoglu, Zeynep. “Matchmakers or tastemakers? : platformization of cultural intermediation & social media's engines for 'making up taste'.” 2018. Doctoral Dissertation, London School of Economics and Political Science (University of London). Accessed January 18, 2021.
http://etheses.lse.ac.uk/4194/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.819636.
MLA Handbook (7th Edition):
Kaparoglu, Zeynep. “Matchmakers or tastemakers? : platformization of cultural intermediation & social media's engines for 'making up taste'.” 2018. Web. 18 Jan 2021.
Vancouver:
Kaparoglu Z. Matchmakers or tastemakers? : platformization of cultural intermediation & social media's engines for 'making up taste'. [Internet] [Doctoral dissertation]. London School of Economics and Political Science (University of London); 2018. [cited 2021 Jan 18].
Available from: http://etheses.lse.ac.uk/4194/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.819636.
Council of Science Editors:
Kaparoglu Z. Matchmakers or tastemakers? : platformization of cultural intermediation & social media's engines for 'making up taste'. [Doctoral Dissertation]. London School of Economics and Political Science (University of London); 2018. Available from: http://etheses.lse.ac.uk/4194/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.819636
University of Birmingham
30.
Alsaif, Mohammed.
Factors affecting citizens' adoption of e-government moderated by socio-cultural values in Saudi Arabia.
Degree: PhD, 2014, University of Birmingham
URL: http://etheses.bham.ac.uk//id/eprint/4851/
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600275
► This study aims to consider the problems associated with the low response of citizens to the adoption of e-government in developing Arab countries, with a…
(more)
▼ This study aims to consider the problems associated with the low response of citizens to the adoption of e-government in developing Arab countries, with a predominant focus on the Kingdom of Saudi Arabia. The study has validated the UTAUT in Saudi Arabia and has extend the theory by including further variable such as the trust, compatibility, awareness and the service quality which proposed to influence citizens adoption of e-government in Saudi Arabia. As the adoption consider as an efficient method to evaluate the success of the implementation. It is necessary for this new innovation to be tailored to citizens’ wishes, and taking into account the religious, cultural, traditional and other beliefs to ensure the widespread adoption of this innovation. The finding reveals that performance expectancy is the strong predictor of the intention to use e-government followed by the trust of the internet. On the other hand, intention to use behaviour, computer self-efficacy and availability of resources found to be significant predictors of the usage behaviour.
Subjects/Keywords: 352.3; H Social Sciences (General); T Technology (General)
Record Details
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Record Details
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
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Manager
APA (6th Edition):
Alsaif, M. (2014). Factors affecting citizens' adoption of e-government moderated by socio-cultural values in Saudi Arabia. (Doctoral Dissertation). University of Birmingham. Retrieved from http://etheses.bham.ac.uk//id/eprint/4851/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600275
Chicago Manual of Style (16th Edition):
Alsaif, Mohammed. “Factors affecting citizens' adoption of e-government moderated by socio-cultural values in Saudi Arabia.” 2014. Doctoral Dissertation, University of Birmingham. Accessed January 18, 2021.
http://etheses.bham.ac.uk//id/eprint/4851/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600275.
MLA Handbook (7th Edition):
Alsaif, Mohammed. “Factors affecting citizens' adoption of e-government moderated by socio-cultural values in Saudi Arabia.” 2014. Web. 18 Jan 2021.
Vancouver:
Alsaif M. Factors affecting citizens' adoption of e-government moderated by socio-cultural values in Saudi Arabia. [Internet] [Doctoral dissertation]. University of Birmingham; 2014. [cited 2021 Jan 18].
Available from: http://etheses.bham.ac.uk//id/eprint/4851/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600275.
Council of Science Editors:
Alsaif M. Factors affecting citizens' adoption of e-government moderated by socio-cultural values in Saudi Arabia. [Doctoral Dissertation]. University of Birmingham; 2014. Available from: http://etheses.bham.ac.uk//id/eprint/4851/ ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600275
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Open Access Theses and Dissertations
