subject:(Centella asiatica)

1. Frederico Pittella Silva. Phytochemical caracterization and biological activities of Centella asiatica (L.) Urban.

Degree: 2008, Universidade Federal de Juiz de Fora

URL: http://www.bdtd.ufjf.br/tde_busca/arquivo.php?codArquivo=219

►

Centella asiatica (L.) Urban is a member of Umbelliferae family that presents pantropical distribution, being frequent around forests and as invaders of grown plants. C.… (more)

▼

Centella asiatica (L.) Urban is a member of Umbelliferae family that presents pantropical distribution, being frequent around forests and as invaders of grown plants. C. asiatica contains triterpenic glycosides such as asiaticoside and madecassoside, and its acids (asiatic and madecassic). These molecules have been responsibles for several activities of its extracts, used to treat neuropsychiatric disorders, asthma, leprosy, ulcers, eczems and on wound healing. Water (EA) and crude methanolic (EBM) extracts were prepared, and the last was fractionated. The citogenetic assay (mitosis) revealed that the chromossomic number was higher than 48. The phytochemical screening showed the presence of flavonoid, heterosides, cumarins, tanins and saponis. The asiaticoside (ASA) was quantified in the extracts by HPLC; EA, EBM and hexanic fraction (FH) showed 84.31%, 70.93% and 57.28% of ASA in its composition. The determination of phenolic constituents revealed 2.86g and 0.60g/ 100g of extract for EA and EBM, respectively. The level of flavonoids for EA and EBM were 0.361mg and 0.271mg/ 100g of extract, respectively. Both EA and EBM showed antioxidant activity against DPPH radical, with IC50 = 31.25 μg/mL and IC50 = 37.16 μg/mL, respectively. The EA inhibited the activity of iPLA2 and cPLA2 in cerebelar samples in a dose-dependent manner. The extracts did not show neither leishmanicidal nor antimicrobial potencial. None toxicity was detected in the Artemia salina model. The EA presented selective antitumor activity against MDA-MB 231 (human breast cancer) and B16F1 (mouse melanoma) cell lines, with IC50 = 648.0 and 698.0 μg/mL, respectively. Creams containing EA and EBM presented wound healing activity. These results confirm and extend the knowledge about popular usage of Centella asiatica (L.) Urban, and confirms the plant as a natural source of molecules with pharmacological potential

Centella asiatica (L.) Urban é membro da família Umbelliferae que apresenta distribuição pantropical, sendo freqüente nas bordas de florestas e como invasoras de outras plantas cultivadas. C. asiatica contém glicosídeos triterpênicos como o asiaticosídeo e madecassosídeo, e seus derivados ácidos (asiático e madecássico). Essas moléculas têm sido responsáveis pelas diversas atividades de seus extratos, usados para o tratamento de doenças neuropsiquiátricas, asma, lepra, úlceras, eczemas e no tratamento de feridas. Foram preparados os extratos aquoso (EA) e bruto metanólico (EBM); este último foi fracionado. A análise citogenética (mitose) revelou que o número cromossômico foi superior a 48. A triagem fitoquímica revelou a presença de flavonóides, heterosídeos, cumarinas, taninos e saponinas. O asiaticosídeo (ASA) foi quantificado nos extratos por HPLC; os EA, EBM e fração hexânica (FH), apresentaram 84,31%, 70,93% e 57,28% de ASA em suas composições. O doseamento dos constituintes fenólicos revelou 2,86g e 0,60g/100g de extrato para EA e EBM, respectivamente. Os teores de flavonóides para EA e EBM foram 0,361mg e 0,271 mg/ 100g de…

Advisors/Committee Members: Silvio Silvério da Silva, Nádia Rezende Barbosa Raposo, Daniel Sales Pimenta.

Subjects/Keywords: GENETICA; atividades biológicas; centella asiatica; Fitoquímica

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Silva, F. P. (2008). Phytochemical caracterization and biological activities of Centella asiatica (L.) Urban. (Thesis). Universidade Federal de Juiz de Fora. Retrieved from http://www.bdtd.ufjf.br/tde_busca/arquivo.php?codArquivo=219

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Silva, Frederico Pittella. “Phytochemical caracterization and biological activities of Centella asiatica (L.) Urban.” 2008. Thesis, Universidade Federal de Juiz de Fora. Accessed January 16, 2021. http://www.bdtd.ufjf.br/tde_busca/arquivo.php?codArquivo=219.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Silva, Frederico Pittella. “Phytochemical caracterization and biological activities of Centella asiatica (L.) Urban.” 2008. Web. 16 Jan 2021.

Vancouver:

Silva FP. Phytochemical caracterization and biological activities of Centella asiatica (L.) Urban. [Internet] [Thesis]. Universidade Federal de Juiz de Fora; 2008. [cited 2021 Jan 16]. Available from: http://www.bdtd.ufjf.br/tde_busca/arquivo.php?codArquivo=219.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silva FP. Phytochemical caracterization and biological activities of Centella asiatica (L.) Urban. [Thesis]. Universidade Federal de Juiz de Fora; 2008. Available from: http://www.bdtd.ufjf.br/tde_busca/arquivo.php?codArquivo=219

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Petit, Virginie. Valorisation phytochimique et biologique de plantes tropicales : Phytochemical and biological enhancement of tropical plants.

Degree: Docteur es, Biologie, 2016, Pau

URL: http://www.theses.fr/2016PAUU3016

►

Ce mémoire de thèse confidentiel porte sur la valorisation phytochimique et biologique de plantes tropicales. Il s’inscrit dans le cadre d’une procédure de validation des… (more)

▼

Ce mémoire de thèse confidentiel porte sur la valorisation phytochimique et biologique de plantes tropicales. Il s’inscrit dans le cadre d’une procédure de validation des acquis de l’expérience et retrace 14 ans de travaux de recherche appliquée pour la mise sur le marché de nouveaux actifs végétaux destinés à l’industrie dermo cosmétique ainsi que des recherches fondamentales. Ce travail a permis le développement de nouveaux actifs, à forte valeur ajoutée, issus de plantes de Madagascar par la valorisation de nombreux métabolites secondaires tels que les polyphénols (flavonoïdes, tannins, dérivés d’acide chlorogénique) et les triterpènes pentacycliques. Cette activité centrale de recherche s’accompagne d’activités essentielles liées à la maitrise de la ressource végétale en lien avec les actions de développement durable, de la recherche phytochimique, du développement de procédé et du positionnement biologique. Il est illustré entre autre le développement d’extraits issus de Buddleja axillaris, Vernonia appendiculata et les derniers travaux sur la plante Centella asiatica.

This confidential memory thesis focuses on phytochemical and biological enhancement of tropical plants. It is part of a process of validation of experience and retraces 14 years of applied research for the development of new plant extract for cosmetics industry and elemental research.This work enabled the development of new actives, with high value, from Madagascar plants by enhancement of secondary metabolites such as polyphenols (flavonoids, tannins, chlorogenic acid derivatives) and pentacyclic triterpenes. This important activity goes along with essential activities related to the mastery of plant resources in line with the sustainable development actions, phytochemical research, process development and biological positioning. It is illustrated, among other developing, extracts from Buddleja axillaris, Vernonia appendiculata and the latest work on the plant Centella asiatica.

Advisors/Committee Members: Laporte-Chrostowska, Anna (thesis director).

Subjects/Keywords: Madagascar; Plantes tropicales; Centella asiatica; Polyphénols; Triterpènes; Anti inflammatoire; Anti oxydant; Madagascar; Tropical plants; Centella asiatica; Polyphenols; Triterpens; Anti inflammatory; Antioxidant

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Petit, V. (2016). Valorisation phytochimique et biologique de plantes tropicales : Phytochemical and biological enhancement of tropical plants. (Doctoral Dissertation). Pau. Retrieved from http://www.theses.fr/2016PAUU3016

Chicago Manual of Style (16^th Edition):

Petit, Virginie. “Valorisation phytochimique et biologique de plantes tropicales : Phytochemical and biological enhancement of tropical plants.” 2016. Doctoral Dissertation, Pau. Accessed January 16, 2021. http://www.theses.fr/2016PAUU3016.

MLA Handbook (7^th Edition):

Petit, Virginie. “Valorisation phytochimique et biologique de plantes tropicales : Phytochemical and biological enhancement of tropical plants.” 2016. Web. 16 Jan 2021.

Vancouver:

Petit V. Valorisation phytochimique et biologique de plantes tropicales : Phytochemical and biological enhancement of tropical plants. [Internet] [Doctoral dissertation]. Pau; 2016. [cited 2021 Jan 16]. Available from: http://www.theses.fr/2016PAUU3016.

Council of Science Editors:

Petit V. Valorisation phytochimique et biologique de plantes tropicales : Phytochemical and biological enhancement of tropical plants. [Doctoral Dissertation]. Pau; 2016. Available from: http://www.theses.fr/2016PAUU3016

University of KwaZulu-Natal

3. Langa, Silvana Paula Octavio. Effects of oleanolic acid and Centella asiatica on enzymes of carbohydrate metabolism in muscle and skin of streptozotocin-induced diabetic Sprague-Dawley rats.

Degree: 2016, University of KwaZulu-Natal

URL: http://hdl.handle.net/10413/16010

► Diabetes prevalence increases yearly with an expected increase to 642 million people by the year 2040. Conventional treatment of diabetes involves insulin therapy and other… (more)

▼ Diabetes prevalence increases yearly with an expected increase to 642 million people by the year 2040. Conventional treatment of diabetes involves insulin therapy and other synthetic drugs. However, drawbacks of these forms of treatments include high cost and adverse side effects. There is therefore, a renewed focus on the use of plants and plant derived products for treatment due to their safety and limited side effects. Oleanolic acid (OA) is a plant derived triterpenoid compound that has been shown to suppress expression of genes encoding hepatic gluconeogenic enzymes and in so doing inhibits hepatic glucose production. Centella asiatica (L.) Urban (CA), an herbaceous plant belonging to the family Umbelliferae, has been traditionally used for the management of diabetes. Thus, this study was aimed at investigating the effects of OA and CA on selected enzymes of carbohydrate metabolism in muscle and skin of streptozotocin- or 10% fructose-streptozotocin-induced diabetic Sprague-Dawley rats. Non-diabetic and diabetic rats were treated with OA, 500 mg/kg of CA, 1000 mg/kg of CA and metformin over 14 days. OA increased HK and PFK activity of diabetic animals by 82% and 432% (p < 0.05) in muscle and 17.7% and 71% in skin respectively. OA also lowered FBPase activity by 24%. Similarly, 500 mg/kg of CA increased HK and PFK activity of diabetic animals by 4.4% and 624% (p < 0.05) in muscle and 11% and 35% in skin respectively. OA and CA reduced PFK expression in both muscle and skin of diabetic animals. CA also increased GS activity by 346% (p < 0.05) in skin of diabetic animals. Treatment with CA decreased ALT and AST levels and reduced damage to muscle fibre and skin epidermis of diabetic animals in histological studies. The findings of this study indicate that hypoglycaemic effect OA and CA may occur through modulation of glycolysis, gluconeogenesis and glycogen synthesis. Tissue damage and structural changes in muscle and skin caused by diabetes may be reduced by treatment with CA. Advisors/Committee Members: Masola, Bubuya. (advisor).

Subjects/Keywords: Centella asiatica.; Type-11 diabetes.; Oleanolic acid.; Rat muscle.; Rat skin.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Langa, S. P. O. (2016). Effects of oleanolic acid and Centella asiatica on enzymes of carbohydrate metabolism in muscle and skin of streptozotocin-induced diabetic Sprague-Dawley rats. (Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/16010

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Langa, Silvana Paula Octavio. “Effects of oleanolic acid and Centella asiatica on enzymes of carbohydrate metabolism in muscle and skin of streptozotocin-induced diabetic Sprague-Dawley rats.” 2016. Thesis, University of KwaZulu-Natal. Accessed January 16, 2021. http://hdl.handle.net/10413/16010.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Langa, Silvana Paula Octavio. “Effects of oleanolic acid and Centella asiatica on enzymes of carbohydrate metabolism in muscle and skin of streptozotocin-induced diabetic Sprague-Dawley rats.” 2016. Web. 16 Jan 2021.

Vancouver:

Langa SPO. Effects of oleanolic acid and Centella asiatica on enzymes of carbohydrate metabolism in muscle and skin of streptozotocin-induced diabetic Sprague-Dawley rats. [Internet] [Thesis]. University of KwaZulu-Natal; 2016. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10413/16010.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Langa SPO. Effects of oleanolic acid and Centella asiatica on enzymes of carbohydrate metabolism in muscle and skin of streptozotocin-induced diabetic Sprague-Dawley rats. [Thesis]. University of KwaZulu-Natal; 2016. Available from: http://hdl.handle.net/10413/16010

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

4. Costa, Fernanda de. Saponinas triterpênicas:biossíntese e atividade biológica.

Degree: 2014, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/106409

►

Saponinas triterpênicas incluem uma ampla variedade de moléculas com diversas aplicações farmacológicas. As saponinas das folhas de Quillaja brasiliensis, espécie nativa do Sul do Brasil,… (more)

▼

Saponinas triterpênicas incluem uma ampla variedade de moléculas com diversas aplicações farmacológicas. As saponinas das folhas de Quillaja brasiliensis, espécie nativa do Sul do Brasil, são estrutural e funcionalmente semelhantes às encontradas nas cascas da espécie chilena Quillaja saponaria, as quais são utilizadas atualmente como adjuvantes em formulações comerciais de vacinas. O perfil de acúmulo da fração imunoadjuvante de saponinas triterpênicas de Q. brasiliensis (QB-90) foi avaliado em resposta a diferentes fatores de estresse. O conteúdo de QB-90 em discos foliares aumentou significativamente com a aplicação de diferentes agentes de estresse osmótico. Também pôde ser observado aumento nos teores de saponinas pela exposição de discos foliares a ácido salicílico, ácido jasmônico, ultrassom e luz ultravioleta C. Experimentos com plântulas indicaram um aumento significativo nos teores de QB-90 com o aumento moderado de irradiância luminosa e pela aplicação de dano mecânico nas folhas. Os resultados obtidos apoiam o papel de defesa induzida que estes metabólitos apresentam in planta. Com o objetivo de avançar os estudos de atividade adjuvante de Q. brasiliensis e ampliar a extensão de antígenos testados, uma vacina contra poliovírus foi avaliada em camundongos. Resultados demonstraram que as formulações de vacinas contendo saponinas da espécie brasileira aumentaram níveis de anticorpos específicos IgG, IgG1 e IgG2a, sugerindo um estímulo de ambos tipos de resposta imune (Th1 e Th2). A resposta celular foi confirmada por ensaios de DTH e pela avaliação dos níveis de mRNA das citocinas IL-2 e IFN- em esplenócitos murinos. A resposta imune de mucosas foi demonstrada pelos aumentos nos níveis de IgA em bile, fezes e lavados vaginais. O segundo objeto de estudo desta Tese é a espécie Centella asiatica (L.) Urban, que também apresenta saponinas triterpênicas bioativas em suas partes aéreas. Uma enzima responsável pela glicosilação de ácido asiático e ácido madecássico foi parcialmente purificada. Usando técnicas de proteômica e dados de sequências de cDNA, a sequência completa do clone que codifica uma glicosiltransferase foi obtida. O produto gênico recombinante, UGT73AD1, foi funcionalmente expresso em Escherichia coli, purificado por cromatografia de afinidade por metal imobilizado e funcionalmente caracterizado. UGT73AD1 foi identificada como sendo uma glicosiltransferase triterpênica de ácidos carboxílicos, provavelmente envolvida na biossíntese de monodesmosídeos da espécie.

Triterpene saponins include a large variety of molecules that find several applications in pharmacology. The saponins from leaves of Quillaja brasiliensis, a native species from Southern Brazil, show structural and functional similarities to those of Quillaja saponaria barks, which are currently used as adjuvants in vaccine formulations. The accumulation patterns of an immunoadjuvant fraction of leaf triterpene saponins (QB-90) in response to stress factors were examined. The content of QB-90 in leaf disks was significantly increased…

Advisors/Committee Members: Fett Neto, Arthur Germano.

Subjects/Keywords: Quillaja brasiliensis; Quillaja brasiliensis : Saponinas; Centella asiatica; Teses; Saponin; Imunoadjuvant; Glucosyltransferase

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Costa, F. d. (2014). Saponinas triterpênicas:biossíntese e atividade biológica. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/106409

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Costa, Fernanda de. “Saponinas triterpênicas:biossíntese e atividade biológica.” 2014. Thesis, Universidade do Rio Grande do Sul. Accessed January 16, 2021. http://hdl.handle.net/10183/106409.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Costa, Fernanda de. “Saponinas triterpênicas:biossíntese e atividade biológica.” 2014. Web. 16 Jan 2021.

Vancouver:

Costa Fd. Saponinas triterpênicas:biossíntese e atividade biológica. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2014. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10183/106409.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Costa Fd. Saponinas triterpênicas:biossíntese e atividade biológica. [Thesis]. Universidade do Rio Grande do Sul; 2014. Available from: http://hdl.handle.net/10183/106409

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal

5. Dladla, Thobekile Precious. Effects of catharanthus roseus and centella asiatica leaf extracts on enzymes of glutamine catabolism in human colon carcinoma (CACO-2) cell line and in enterocytes from male sprague-dawley rats.

Degree: 2015, University of KwaZulu-Natal

URL: http://hdl.handle.net/10413/15537

► Phosphate-dependent glutaminase (PDG) is a key enzyme in several physiological processes and hence has become a target of anti-cancer drug development because of the role… (more)

▼ Phosphate-dependent glutaminase (PDG) is a key enzyme in several physiological processes and hence has become a target of anti-cancer drug development because of the role of glutamine in providing energy for rapidly dividing cells. This study investigated the effects of the Centella asiatica and Catharanthus roseus leaf extracts on enzymes of glutamine catabolism in human colon carcinoma (Caco-2) cell line and in enterocytes from Sprague-Dawely rats both treated with plant extracts. Our hypothesis was that these extracts would arrest the growth of Caco-2 cells by inhibiting glutaminase but have less deleterious effects on normal cells due to the former being more avid consumers of glutamine. The 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay was used to assess the cytotoxic effects, and hence the anti-cancer potential of extracts from medicinal plants C. asiatica and C. roseus against Caco-2 and human embryonic kidney (HEK 293) cell lines. These in vitro effects were assessed using various doses of plant extracts (0- 16 mg/ml) and different exposure periods of 24, 48 and 72 h. Results show that the cytotoxicity effect of the C. asiatica extract to the caco-2 cell line is dose dependent whilst C. roseus treatment decreased the Caco-2 cells viability at all the exposure times but this was not dose-dependent. In contrast, both extracts significantly increased cell proliferation of the HEK 293 cells compared to the controls. The PDG and ALT activities were decreased in Caco-2 cells whilst the HEK293 cells were largely unaffected. In the in vivo studies, the activities of phosphate-dependent glutaminase (PDG), glutamate dehydrogenase (GDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were determined in the enterocytes. Results show that the activities of GDH remained constant whilst there was a decrease in ALT and a slight increase in AST activities in the enterocytes in both the C. asiatica and C. roseus treated groups. The PDG enterocytes activity, on the other hand, was lower in both the treated groups compared to the control group. Expression of both PDG and AST assessed by dot blots in the enterocytes increased in both plant extract treated groups. Induction of apoptosis was also investigated using cytochrome c. The plant extracts were screened for presence of phytocomponents that may be causing changes in Caco-2 cell growth and in enzymes of glutamine catabolism using Gas Chromatography-Mass Spectrometry (GC-MS) and qualitative phytochemical analysis. The extracts revealed the presence of anticancer and many other compounds. We conclude that the both extracts have potent anti-cancer cell activity that leaves normal cells unaffected, in fact stimulating their growth. Advisors/Committee Members: Masola, Bubuya. (advisor), Singh, Moganavelli. (advisor).

Subjects/Keywords: Theses - Biochemistry.; Phosphate-dependent glutaminase.; Anti-cancer.; Centella Asiatica.; Catharanthus roseus leaf.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dladla, T. P. (2015). Effects of catharanthus roseus and centella asiatica leaf extracts on enzymes of glutamine catabolism in human colon carcinoma (CACO-2) cell line and in enterocytes from male sprague-dawley rats. (Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/15537

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dladla, Thobekile Precious. “Effects of catharanthus roseus and centella asiatica leaf extracts on enzymes of glutamine catabolism in human colon carcinoma (CACO-2) cell line and in enterocytes from male sprague-dawley rats.” 2015. Thesis, University of KwaZulu-Natal. Accessed January 16, 2021. http://hdl.handle.net/10413/15537.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dladla, Thobekile Precious. “Effects of catharanthus roseus and centella asiatica leaf extracts on enzymes of glutamine catabolism in human colon carcinoma (CACO-2) cell line and in enterocytes from male sprague-dawley rats.” 2015. Web. 16 Jan 2021.

Vancouver:

Dladla TP. Effects of catharanthus roseus and centella asiatica leaf extracts on enzymes of glutamine catabolism in human colon carcinoma (CACO-2) cell line and in enterocytes from male sprague-dawley rats. [Internet] [Thesis]. University of KwaZulu-Natal; 2015. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10413/15537.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dladla TP. Effects of catharanthus roseus and centella asiatica leaf extracts on enzymes of glutamine catabolism in human colon carcinoma (CACO-2) cell line and in enterocytes from male sprague-dawley rats. [Thesis]. University of KwaZulu-Natal; 2015. Available from: http://hdl.handle.net/10413/15537

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Wankhar, Borabell. Biology of Centella asiatica _linn_ URB, a medicinally important clonal perennial; -.

Degree: Botany, 1987, North-Eastern Hill University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/54842

Abstract not available newline newline

Summary p. 122-129, Bibliography p. 130-175

Advisors/Committee Members: Tripathi, R S.

Subjects/Keywords: Biology; Centella asiatica _Linn_ URB; Medicinally; Clonal Perennial

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wankhar, B. (1987). Biology of Centella asiatica _linn_ URB, a medicinally important clonal perennial; -. (Thesis). North-Eastern Hill University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/54842

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wankhar, Borabell. “Biology of Centella asiatica _linn_ URB, a medicinally important clonal perennial; -.” 1987. Thesis, North-Eastern Hill University. Accessed January 16, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/54842.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wankhar, Borabell. “Biology of Centella asiatica _linn_ URB, a medicinally important clonal perennial; -.” 1987. Web. 16 Jan 2021.

Vancouver:

Wankhar B. Biology of Centella asiatica _linn_ URB, a medicinally important clonal perennial; -. [Internet] [Thesis]. North-Eastern Hill University; 1987. [cited 2021 Jan 16]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/54842.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wankhar B. Biology of Centella asiatica _linn_ URB, a medicinally important clonal perennial; -. [Thesis]. North-Eastern Hill University; 1987. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/54842

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

7. Saibu, Olusola Surajudeen. Analysis of three wetland medicinal plants: Centella asiatica, Cyperus longus and Typha capensis found in the Western Cape Province of South Africa.

Degree: 2017, University of the Western Cape

URL: http://hdl.handle.net/11394/6356

► South Africa is recognised worldwide for its rich diversity of plants, many of which have been used in ethno-medicine. However, the use of wetland plant… (more)

▼ South Africa is recognised worldwide for its rich diversity of plants, many of which have been used in ethno-medicine. However, the use of wetland plant species in ethno-medicine required further investigations. This research is aimed at investigating three wetland medicinal, plant species, Centella asiatica, Cyperus longus and Typha capensis based on their geographical, seasonal, mineral nutrient (Fe, Mn, Ca, Mg, K and Na) and secondary metabolite characteristics. Samples of each species were collected from Grabouw, Kelderhoff, Kenilworth, Pringle Bay, University of the Western Cape (UWC) and Worcester within the Western Cape Province of South Africa. Specimen and soil collections were carried out during autumn, spring, summer and winter of 2014. Both plant and soil samples were acid digested and mineral nutrient concentrations in the samples were analysed using an atomic absorption spectrometer (AAS). Secondary metabolites were determined using analytical TLC on normal phase Merck-Silva gel coated aluminium plates as well as by using HPLC separation from crude extracts of C. asiatica, C. longus and T. capensis using LC-MS hardware from Agilent. The elemental analysis of soil samples showed that Ca, K, Mg, Mn and Zn concentrations were predominantly low. Soil mineral concentrations increased progressively from inland (Worcester) towards the coastland in the south (Pringle Bay). Calcium and sodium concentrations, in particular, were higher in soil samples obtained from Grabouw (inland south) and decreased northward towards Worcester. Comparatively, plant mineral concentrations were generally higher than soil concentrations. The high concentration of some of these essential elements, in selected plants is an indication that these plant species could be a good source of essential elements. High concentrations of phytochemicals were found in Centella asiatica during winter, while Cyperus longus and Typha capensis exhibited high concentrations during autumn indicating variation in respect of season. Consequently, harvesting of the studied plants should be done at the season with a relatively high phytochemical concentration. Studies are needed to investigate the extent of pesticide or herbicide contamination in wetland plants to protect the health of users. The LC-MS analyses of the three study species showed that seasonal variation affects metabolite constituents and moreover that these metabolite constituents differ from one locality to another. The seasonal variation of the elements in the studied medicinal plants justified the importance of harvesting seasons in the optimal utilization of the studied plants for medicinal purpose. s, for C. asiatica, anti-bacterial treatments for C. longus and fertility enhancement and birth control for T. capensis. Advisors/Committee Members: Smit, A.J (advisor), Mabusela, W.T (advisor).

Subjects/Keywords: Centella asiatica; Cyperus longus; Elemental analysis; Macro elements; Micro elements; Phytochemical analysis; Typha capensis; Seasons; Western Cape; Wetland medicinal plants

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Saibu, O. S. (2017). Analysis of three wetland medicinal plants: Centella asiatica, Cyperus longus and Typha capensis found in the Western Cape Province of South Africa. (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/6356

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Saibu, Olusola Surajudeen. “Analysis of three wetland medicinal plants: Centella asiatica, Cyperus longus and Typha capensis found in the Western Cape Province of South Africa. ” 2017. Thesis, University of the Western Cape. Accessed January 16, 2021. http://hdl.handle.net/11394/6356.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Saibu, Olusola Surajudeen. “Analysis of three wetland medicinal plants: Centella asiatica, Cyperus longus and Typha capensis found in the Western Cape Province of South Africa. ” 2017. Web. 16 Jan 2021.

Vancouver:

Saibu OS. Analysis of three wetland medicinal plants: Centella asiatica, Cyperus longus and Typha capensis found in the Western Cape Province of South Africa. [Internet] [Thesis]. University of the Western Cape; 2017. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/11394/6356.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Saibu OS. Analysis of three wetland medicinal plants: Centella asiatica, Cyperus longus and Typha capensis found in the Western Cape Province of South Africa. [Thesis]. University of the Western Cape; 2017. Available from: http://hdl.handle.net/11394/6356

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of KwaZulu-Natal

8. Oyenihi, Ayodeji Babatunde. Antidiabetic properties of centella asiatica in type II diabetic rats.

Degree: 2016, University of KwaZulu-Natal

URL: http://hdl.handle.net/10413/15593

Abstract available in PDF file. Advisors/Committee Members: Masola, Bubuya. (advisor), Mukaratirwa, Samson. (advisor).

Subjects/Keywords: Theses - Biochemistry.; Centella Asiatica.; Diabetics.; Antioxidants.; Lipids.; Cytokines.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Oyenihi, A. B. (2016). Antidiabetic properties of centella asiatica in type II diabetic rats. (Thesis). University of KwaZulu-Natal. Retrieved from http://hdl.handle.net/10413/15593

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Oyenihi, Ayodeji Babatunde. “Antidiabetic properties of centella asiatica in type II diabetic rats.” 2016. Thesis, University of KwaZulu-Natal. Accessed January 16, 2021. http://hdl.handle.net/10413/15593.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Oyenihi, Ayodeji Babatunde. “Antidiabetic properties of centella asiatica in type II diabetic rats.” 2016. Web. 16 Jan 2021.

Vancouver:

Oyenihi AB. Antidiabetic properties of centella asiatica in type II diabetic rats. [Internet] [Thesis]. University of KwaZulu-Natal; 2016. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10413/15593.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Oyenihi AB. Antidiabetic properties of centella asiatica in type II diabetic rats. [Thesis]. University of KwaZulu-Natal; 2016. Available from: http://hdl.handle.net/10413/15593

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Mahatma Gandhi University

9. Joy, Jisha. Modification of cellular radiosensitivity by phytoceuticals and herbal extracts: Mechanisms and relevance;.

Degree: Biochemistry, 2014, Mahatma Gandhi University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/25801

newline

Bibliography p. 170-200

Advisors/Committee Members: Nair, C K K.

Subjects/Keywords: Anti inflammation; Antioxidants; Cellular radio sensitivity; Centella asiatica; DNA damage; DNA repair; Holarrhena antidysenterica; Micro nucleus; Radio protection; Rubia cordifoila

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Joy, J. (2014). Modification of cellular radiosensitivity by phytoceuticals and herbal extracts: Mechanisms and relevance;. (Thesis). Mahatma Gandhi University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/25801

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Joy, Jisha. “Modification of cellular radiosensitivity by phytoceuticals and herbal extracts: Mechanisms and relevance;.” 2014. Thesis, Mahatma Gandhi University. Accessed January 16, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/25801.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Joy, Jisha. “Modification of cellular radiosensitivity by phytoceuticals and herbal extracts: Mechanisms and relevance;.” 2014. Web. 16 Jan 2021.

Vancouver:

Joy J. Modification of cellular radiosensitivity by phytoceuticals and herbal extracts: Mechanisms and relevance;. [Internet] [Thesis]. Mahatma Gandhi University; 2014. [cited 2021 Jan 16]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/25801.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Joy J. Modification of cellular radiosensitivity by phytoceuticals and herbal extracts: Mechanisms and relevance;. [Thesis]. Mahatma Gandhi University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/25801

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universitat de Barcelona

10. Mangas Alonso, Susana. Producción de saponinas triterpénicas en cultivos in vitro de "Centella asiatica".

Degree: Departament de Productes Naturals, Biologia Vegetal i Edafologia, 2009, Universitat de Barcelona

URL: http://hdl.handle.net/10803/2622

► <i>Centella asiatica</i> is a herbaceous plant with great medicinal value, which has been used in traditional medicine as an antipyretic, diuretic and in the treatment… (more)

Subjects/Keywords: Expressió gènica; Cultiu in vitro; Biotecnologia; Elicitació; Saponines triterpèniques; <; i>; Centella asiatica<; /i>;

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mangas Alonso, S. (2009). Producción de saponinas triterpénicas en cultivos in vitro de "Centella asiatica". (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/2622

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mangas Alonso, Susana. “Producción de saponinas triterpénicas en cultivos in vitro de "Centella asiatica".” 2009. Thesis, Universitat de Barcelona. Accessed January 16, 2021. http://hdl.handle.net/10803/2622.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mangas Alonso, Susana. “Producción de saponinas triterpénicas en cultivos in vitro de "Centella asiatica".” 2009. Web. 16 Jan 2021.

Vancouver:

Mangas Alonso S. Producción de saponinas triterpénicas en cultivos in vitro de "Centella asiatica". [Internet] [Thesis]. Universitat de Barcelona; 2009. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10803/2622.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mangas Alonso S. Producción de saponinas triterpénicas en cultivos in vitro de "Centella asiatica". [Thesis]. Universitat de Barcelona; 2009. Available from: http://hdl.handle.net/10803/2622

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations