subject:(Cell adhesion molecules)

Rutgers University

1. Vedula, Pavan, 1988-. Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function.

Degree: PhD, Biology, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/50570/

► The β-actin mRNA contains a 28 nucleotide sequence in the 3′UTR termed the zipcode which, along with a trans acting factor called the Zipcode Binding… (more)

▼ The β-actin mRNA contains a 28 nucleotide sequence in the 3′UTR termed the zipcode which, along with a trans acting factor called the Zipcode Binding Protein-1 (ZBP-1/IMP-1), regulates the spatio-temporal expression pattern of the β-actin. This mode of post-transcriptional gene regulation is required for several cellular processes including cell migration, cell-cell adhesion, and cell-matrix adhesion. Adding to the list of signaling cascades such as RhoA and Src, work in this thesis demonstrates E-cadherin endocytosis, and plausibly gene expression pathways regulating cell proliferation, converge on spatially regulated β-actin translation. E-cadherin endocytosis and recycling has been shown to be important during the maintenance of epithelial adherens junctions. However in this thesis, endocytosis of E-cadherin is shown to negatively regulate adherens junction assembly, while spatially regulated β-actin translation balances this by promoting actin filament anchoring of cadherin complexes. Mislocalization of β-actin translation impairs adherens junction maturation in epithelial cells following de novo cell-cell contact. These results have implications in development and disease where the assembly and maintenance of epithelial adherens junctions is essential. In order to quantify the extent of adherens junction assembly defects in epithelial cells following de novo contact, a Fluorescence Covariance Index based on calculating Pearson’s Correlation Coefficients was developed and validated using several components of the adherens junction complex. In addition to quantitating the morphological effects of mislocalizing β-actin translation on adherens junctions, the FCI analysis showed correlation of these morphological defects with loss of epithelial barrier function. Lastly, inhibiting dynamin mediated endocytosis rescued adherens junction structure and epithelial barrier function in cells with partially mislocalized β-actin. Using Matrigel embedded 3D cyst cultures of MDCK cells, spatially regulated β-actin translation was shown to have an effect on cell shape, size and proliferation during epithelial morphogenesis. These defects in assembling a normal 3D epithelium along with disorganized acto-myosin and tight junctions, point to a role for compartmentalized β-actin translation in regulating a mechanosensitive module – plausibly Hippo and/or YAP/TAZ pathways. Finally, collective cell migration, an important paradigm in several biological processes such as wound repair and development, was used to determine the role of spatially regulated β-actin translation in epithelial wound repair. Spatially regulated β-actin translation is shown to regulate actin flux at cell-cell adhesions in leader-follower cell pairs to control tissue migration rates. Although cells with partially mislocalized β-actin translation have a more active leading edge, this increased protrusive activity fails to translate into increased migratory rate. These data taken together suggest that collective cell migration in epithelial sheets is an emergent… Advisors/Committee Members: Weber, Gregory F (chair), Rodriguez, Alexis J (internal member), Gao, Nan (internal member), Bonder, Edward M (internal member), Hinchcliffe, Edward (outside member), Hinchcliffe, Edward H (outside member).

Subjects/Keywords: Cell adhesion molecules

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APA (6^th Edition):

Vedula, Pavan, 1. (2016). Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/50570/

Chicago Manual of Style (16^th Edition):

Vedula, Pavan, 1988-. “Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function.” 2016. Doctoral Dissertation, Rutgers University. Accessed February 27, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/50570/.

MLA Handbook (7^th Edition):

Vedula, Pavan, 1988-. “Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function.” 2016. Web. 27 Feb 2021.

Vancouver:

Vedula, Pavan 1. Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Feb 27]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/50570/.

Council of Science Editors:

Vedula, Pavan 1. Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/50570/

Rutgers University

2. Gutierrez, Natasha C., 1987-. Contact localized β-actin translation drives epithelial adherens junction assembly.

Degree: PhD, Biology, 2014, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/45628/

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Adherens junctions are multi-protein adhesion complexes that anchor to the actin cytoskeleton at cell-cell contact sites to stimulate tissue assembly and thereby regulate barrier maintenance,… (more)

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Adherens junctions are multi-protein adhesion complexes that anchor to the actin cytoskeleton at cell-cell contact sites to stimulate tissue assembly and thereby regulate barrier maintenance, epithelial tissue homeostasis, and embryonic development. Previously it was demonstrated that the mRNA for β-actin contains a nucleotide sequence in its 3’ UTR, called the zipcode, which is necessary for targeting and translational regulation of this transcript. The zipcode sequence is recognized by the translation regulator zipcode binding protein-1, ZBP1. Additionally, deleting zipcode sequences causes mislocalization of their mRNA transcript. Here we show mislocalizing β-actin’s monomer synthesis inhibits adherens junction assembly following epithelial cell-cell contact. Additionally, inhibiting RhoA and Src signaling, required for β-actin mRNA zipcode-mediated spatially regulated β-actin translation, prevents adherens junction assembly and significantly perturbs epithelial barrier integrity. In fact, TRITC-dextran barrier permeability significantly increases in epithelial cells expressing β-actin transcripts without the 3’ untranslated region (Δ3’UTR-β-actin) at steady state and in the hours post-contact compared to full-length expressing cells. Moreover, in full-length β-actin GFP (FL-β-actin GFP) expressing cells, β-actin mRNA zipcode antisense oligonucleotide masking of the zipcode sequence also perturbs barrier maintenance. Intriguingly, chemically inhibiting the signaling pathways required for β-actin mRNA localization and local translation (RhoA and Src) also perturbs epithelial barrier maintenance. Taken together, we demonstrate epithelial cell-cell contact stimulates E-cadherin mediated signaling to spatially regulate β-actin mRNA zipcode-dependent monomer synthesis thereby driving adherens junction assembly, cell, and tissue adhesion required for proper epithelial tissue function.

Natasha C. Gutierrez

Advisors/Committee Members: Rodriguez, Alexis (chair), Bonder, Edward (internal member), Gao, Nan (internal member), Larson, Daniel (outside member).

Subjects/Keywords: Actin; Cell adhesion molecules; Cell receptors

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APA (6^th Edition):

Gutierrez, Natasha C., 1. (2014). Contact localized β-actin translation drives epithelial adherens junction assembly. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/45628/

Chicago Manual of Style (16^th Edition):

Gutierrez, Natasha C., 1987-. “Contact localized β-actin translation drives epithelial adherens junction assembly.” 2014. Doctoral Dissertation, Rutgers University. Accessed February 27, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/45628/.

MLA Handbook (7^th Edition):

Gutierrez, Natasha C., 1987-. “Contact localized β-actin translation drives epithelial adherens junction assembly.” 2014. Web. 27 Feb 2021.

Vancouver:

Gutierrez, Natasha C. 1. Contact localized β-actin translation drives epithelial adherens junction assembly. [Internet] [Doctoral dissertation]. Rutgers University; 2014. [cited 2021 Feb 27]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45628/.

Council of Science Editors:

Gutierrez, Natasha C. 1. Contact localized β-actin translation drives epithelial adherens junction assembly. [Doctoral Dissertation]. Rutgers University; 2014. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/45628/

University of Texas Southwestern Medical Center

3. Etherton, Mark Richard. Molecular Pathogenesis of Autism: A Role for Neurexin and Neuroligin.

Degree: 2012, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/1106

► The Autism Spectrum Disorders (ASDs) represent a clinically heterogeneous group of diseases that share deficits in three core domains: social interaction, communication, and repetitive behaviors… (more)

▼ The Autism Spectrum Disorders (ASDs) represent a clinically heterogeneous group of diseases that share deficits in three core domains: social interaction, communication, and repetitive behaviors and/or restricted interests. The strong genetic basis of these disorders, which was demonstrated by multiple twin and family studies, has prompted the search for candidate genes. Neurexin and neuroligin, trans-synaptic ligands for each other, are two families of synaptic cell-adhesion molecules that have been linked to ASD pathogenesis. I found that three different mouse models for ASDs, the neurexin-1α deletion, the neuroligin-3 (NL3) R451C mutation, and the NL3 R704C mutation all aberrantly alter synaptic transmission. First, I showed that deletion of neurexin-1α in a mouse, which induced behavioral abnormalities consistent with increased repetitive behaviors, significantly reduced AMPA-receptor mediated synaptic transmission in the hippocampus. Next, I demonstrated that the NL3 R451C mutation, which has impaired social interaction, has circuit-specific abnormalities in synaptic transmission. In the somatosensory cortex, inhibitory transmission is enhanced, while in the hippocampus, excitatory transmission is increased. I went on to demonstrate that in the hippocampus, the NL3 R451C mutation appears to deleteriously impair synapse morphogenesis. Lastly, I found that the NL3 R704C mouse model also had a significant reduction in AMPA-receptor mediated transmission in the hippocampus. Taken together, these findings suggest several points. First, each of these mouse models has abnormalities in synaptic transmission, indicative of a synaptic pathology to ASD. Secondly, each of the dysfunctions in synaptic transmission are different, suggesting that comparable to the disease presentation, the pathology may also be heterogeneous. Lastly, for one mouse model, the NL3 R451C, the synaptic deficits were circuit specific, highlighting the observation that ASDs may be an manifestation of variable dysfunctions in multiple brain regions. Advisors/Committee Members: Südhof, Thomas C..

Subjects/Keywords: Autistic Disorders; Neural Cell Adhesion Molecules; Cognition

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APA (6^th Edition):

Etherton, M. R. (2012). Molecular Pathogenesis of Autism: A Role for Neurexin and Neuroligin. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/1106

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Etherton, Mark Richard. “Molecular Pathogenesis of Autism: A Role for Neurexin and Neuroligin.” 2012. Thesis, University of Texas Southwestern Medical Center. Accessed February 27, 2021. http://hdl.handle.net/2152.5/1106.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Etherton, Mark Richard. “Molecular Pathogenesis of Autism: A Role for Neurexin and Neuroligin.” 2012. Web. 27 Feb 2021.

Vancouver:

Etherton MR. Molecular Pathogenesis of Autism: A Role for Neurexin and Neuroligin. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2012. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2152.5/1106.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Etherton MR. Molecular Pathogenesis of Autism: A Role for Neurexin and Neuroligin. [Thesis]. University of Texas Southwestern Medical Center; 2012. Available from: http://hdl.handle.net/2152.5/1106

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

4. Pantović-Stefanović, Maja, 1983-. Nivoi međućelijskog adhezionog molekula-1 i vaskularnog ćelijskog adhezionog molekula-1 u serumu obolelih od bipolarnog afektivnog poremećaja i shizofrenije.

Degree: Medicinski fakultet, 2016, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:13238/bdef:Content/get

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Medicina - Psihijatrija / Medicine - Psychiatry

Uvod. Ćelijski adhezioni molekuli imaju važnu ulogu u inflamatornim procesima za koje se veruje da posreduju u nastanku… (more)

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Medicina - Psihijatrija / Medicine - Psychiatry

Uvod. Ćelijski adhezioni molekuli imaju važnu ulogu u inflamatornim procesima za koje se veruje da posreduju u nastanku psihotičnih i afektivnih duševnih oboljenja. Ciljevi istraživanja. Ciljevi sitraživanja bili su: odredjivanje nivoa serumskih koncentracija solubilnog medjućelijskog adhezionog molekula-1 (sICAM-1) i solubilnog vaskularnog ćelijskog molekula-1 (sVCAM-1) kod obolelih od bipolarnog afektivnog poremećaja (BAP) i shizofrenije (SCH) i zdravih ispitanika; poredjenje serumskih koncentracija sICAM-1 i sVCAM-1 obolelih u odnosu na zdrave ispitanike; ispitivanje promene serumskih koncentracija sICAM-1 i sVCAM-1 u remisiji u odnosu na akutnu fazu bolesti kod BAP/SCH; i finalno, ispitivanje povezanosti nivoa sICAM-1 i sVCAM-1 sa stepenom psihopatologije, kliničkim karakteristkama toka bolesti i primenjenim farmakoterapijskim protokolima. Materijal i metod. Istraživanje predstavlja kliničku, prospektivnu, otvorenu, eksperimentalnu studiju ispitivanja serumskih nivoa sICAM-1 i sVCAM-1 kod obolelih od BAP (n = 82) i SCH (n = 66) u akutnoj fazi bolesti i remisiji, u odnosu na i zdrave ispitanike (n = 73). Podaci su prikupljeni putem sledećih upitnika: polu-strukturisani psihijatrijski upitnik, skala opšteg kliničkog utiska, skala globalne ocene funkcionisanja, kratka skala za psihijatrijsku procenu, skala za procenu pozitivnog i negativnog sindroma shizofrenije, Montgomeri-Ašberg skala za procenu depresivnosti, Jangova skala za procenu manije, skala za procenu shizo-bipolarnosti. Odredjivanje serumskih nivoa koncentracije adhezionih molekula vršeno je ELISA metodom. U okviru studije obavljena je procene težine bolesti, prisutne psihopatologije, toka bolesti i akutne i longitudinalne primene farmakoterapije. U statističkoj obradi podataka su korišćene metode deskriptivne statistike, metode bivarijatne analitičke statistike (Studentov t-test za nezavisne uzorke, χ2- test, korelaciona analiza) i multivarijatne metode (parcijalna korelaciona analiza, linearna regresiona analiza, ANCOVA analiza, analiza medijatorskih i moderatorskih efekata). Kao kovarijate upotrebljeni su pol, pušacki status, indeks telesne mase i starost...

Advisors/Committee Members: Ivković, Maja.

Subjects/Keywords: cell adhesion molecules; bipolar disorder; schizophrenia

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APA (6^th Edition):

Pantović-Stefanović, Maja, 1. (2016). Nivoi međućelijskog adhezionog molekula-1 i vaskularnog ćelijskog adhezionog molekula-1 u serumu obolelih od bipolarnog afektivnog poremećaja i shizofrenije. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:13238/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pantović-Stefanović, Maja, 1983-. “Nivoi međućelijskog adhezionog molekula-1 i vaskularnog ćelijskog adhezionog molekula-1 u serumu obolelih od bipolarnog afektivnog poremećaja i shizofrenije.” 2016. Thesis, Univerzitet u Beogradu. Accessed February 27, 2021. https://fedorabg.bg.ac.rs/fedora/get/o:13238/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pantović-Stefanović, Maja, 1983-. “Nivoi međućelijskog adhezionog molekula-1 i vaskularnog ćelijskog adhezionog molekula-1 u serumu obolelih od bipolarnog afektivnog poremećaja i shizofrenije.” 2016. Web. 27 Feb 2021.

Vancouver:

Pantović-Stefanović, Maja 1. Nivoi međućelijskog adhezionog molekula-1 i vaskularnog ćelijskog adhezionog molekula-1 u serumu obolelih od bipolarnog afektivnog poremećaja i shizofrenije. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2021 Feb 27]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:13238/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pantović-Stefanović, Maja 1. Nivoi međućelijskog adhezionog molekula-1 i vaskularnog ćelijskog adhezionog molekula-1 u serumu obolelih od bipolarnog afektivnog poremećaja i shizofrenije. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:13238/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

5. Silwal, Prabhisha. A trans-synaptic mechanism for the development and function of a neural circuit.

Degree: Physiology and Pathophysiology, 2020, University of Manitoba

URL: http://hdl.handle.net/1993/34629

► Synapses are formed by high affinity trans-synaptic interactions between pre- and post- synaptic proteins. Any disturbance in these interactions may affect synaptogenesis. We assessed the… (more)

Subjects/Keywords: Synapse; neurexins; LRRTMs; cell adhesion molecules

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APA (6^th Edition):

Silwal, P. (2020). A trans-synaptic mechanism for the development and function of a neural circuit. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/34629

Chicago Manual of Style (16^th Edition):

Silwal, Prabhisha. “A trans-synaptic mechanism for the development and function of a neural circuit.” 2020. Masters Thesis, University of Manitoba. Accessed February 27, 2021. http://hdl.handle.net/1993/34629.

MLA Handbook (7^th Edition):

Silwal, Prabhisha. “A trans-synaptic mechanism for the development and function of a neural circuit.” 2020. Web. 27 Feb 2021.

Vancouver:

Silwal P. A trans-synaptic mechanism for the development and function of a neural circuit. [Internet] [Masters thesis]. University of Manitoba; 2020. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/1993/34629.

Council of Science Editors:

Silwal P. A trans-synaptic mechanism for the development and function of a neural circuit. [Masters Thesis]. University of Manitoba; 2020. Available from: http://hdl.handle.net/1993/34629

University of British Columbia

6. Carpenito, Carmine. Expression and functional analysis of murine intercellular adhesion molecule 1 (ICAM-1).

Degree: MS- MSc, Medical Genetics, 1990, University of British Columbia

URL: http://hdl.handle.net/2429/28939

► Cell adhesion molecules enhance Interactions between adjacent cells In order to mediate a large variety of functions of the Immune system. An antibody against the… (more)

Subjects/Keywords: Cell adhesion molecules

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APA (6^th Edition):

Carpenito, C. (1990). Expression and functional analysis of murine intercellular adhesion molecule 1 (ICAM-1). (Masters Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/28939

Chicago Manual of Style (16^th Edition):

Carpenito, Carmine. “Expression and functional analysis of murine intercellular adhesion molecule 1 (ICAM-1).” 1990. Masters Thesis, University of British Columbia. Accessed February 27, 2021. http://hdl.handle.net/2429/28939.

MLA Handbook (7^th Edition):

Carpenito, Carmine. “Expression and functional analysis of murine intercellular adhesion molecule 1 (ICAM-1).” 1990. Web. 27 Feb 2021.

Vancouver:

Carpenito C. Expression and functional analysis of murine intercellular adhesion molecule 1 (ICAM-1). [Internet] [Masters thesis]. University of British Columbia; 1990. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2429/28939.

Council of Science Editors:

Carpenito C. Expression and functional analysis of murine intercellular adhesion molecule 1 (ICAM-1). [Masters Thesis]. University of British Columbia; 1990. Available from: http://hdl.handle.net/2429/28939

University of Aberdeen

7. Bruce, Freyja Mairi. Determining the roles of DSCAM and SDK proteins in vertebrate visual system development.

Degree: PhD, 2012, University of Aberdeen

URL: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153461990005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554288

► Axons are directed along stereotypic pathways to their targets by cues arrayed in the extracellular environment. Identifying the cellular and molecular nature of these signals… (more)

Subjects/Keywords: 612.81046; Axons; Cell Adhesion Molecules; Visual Pathways

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APA (6^th Edition):

Bruce, F. M. (2012). Determining the roles of DSCAM and SDK proteins in vertebrate visual system development. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153461990005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554288

Chicago Manual of Style (16^th Edition):

Bruce, Freyja Mairi. “Determining the roles of DSCAM and SDK proteins in vertebrate visual system development.” 2012. Doctoral Dissertation, University of Aberdeen. Accessed February 27, 2021. https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153461990005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554288.

MLA Handbook (7^th Edition):

Bruce, Freyja Mairi. “Determining the roles of DSCAM and SDK proteins in vertebrate visual system development.” 2012. Web. 27 Feb 2021.

Vancouver:

Bruce FM. Determining the roles of DSCAM and SDK proteins in vertebrate visual system development. [Internet] [Doctoral dissertation]. University of Aberdeen; 2012. [cited 2021 Feb 27]. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153461990005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554288.

Council of Science Editors:

Bruce FM. Determining the roles of DSCAM and SDK proteins in vertebrate visual system development. [Doctoral Dissertation]. University of Aberdeen; 2012. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153461990005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.554288

University of Hong Kong

8. 胡梦龙. Structural studies on human PECAM-1 trans-homophilic dimerization revealing cell adhesion mechanism.

Degree: 2017, University of Hong Kong

URL: http://hdl.handle.net/10722/241302

► Platelet/Endothelial Cell Adhesion Molecule-1, abbreviated to PECAM-1 and also known as CD31, is a member of cell adhesion molecules. It participates in cell adhesion by… (more)

Subjects/Keywords: Cell adhesion molecules; Cell adhesion

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APA (6^th Edition):

胡梦龙. (2017). Structural studies on human PECAM-1 trans-homophilic dimerization revealing cell adhesion mechanism. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/241302

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

胡梦龙. “Structural studies on human PECAM-1 trans-homophilic dimerization revealing cell adhesion mechanism.” 2017. Thesis, University of Hong Kong. Accessed February 27, 2021. http://hdl.handle.net/10722/241302.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

胡梦龙. “Structural studies on human PECAM-1 trans-homophilic dimerization revealing cell adhesion mechanism.” 2017. Web. 27 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

胡梦龙. Structural studies on human PECAM-1 trans-homophilic dimerization revealing cell adhesion mechanism. [Internet] [Thesis]. University of Hong Kong; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10722/241302.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

胡梦龙. Structural studies on human PECAM-1 trans-homophilic dimerization revealing cell adhesion mechanism. [Thesis]. University of Hong Kong; 2017. Available from: http://hdl.handle.net/10722/241302

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Columbia University

9. Nader, Guilherme Pedreira de F. FAK and SRC Kinases Maintain Integrin Activation During Endocytic Recycling to Polarize Adhesion Formation.

Degree: 2015, Columbia University

URL: https://doi.org/10.7916/D8TH8KG0

► Integrin recycling has been generally assumed to be important for cell migration but the trafficking pathways and the molecules regulating integrin trafficking remain poorly characterized.… (more)

Subjects/Keywords: Protein kinases; Focal adhesion kinase; Cell adhesion molecules; Integrins; Biology

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APA (6^th Edition):

Nader, G. P. d. F. (2015). FAK and SRC Kinases Maintain Integrin Activation During Endocytic Recycling to Polarize Adhesion Formation. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8TH8KG0

Chicago Manual of Style (16^th Edition):

Nader, Guilherme Pedreira de F. “FAK and SRC Kinases Maintain Integrin Activation During Endocytic Recycling to Polarize Adhesion Formation.” 2015. Doctoral Dissertation, Columbia University. Accessed February 27, 2021. https://doi.org/10.7916/D8TH8KG0.

MLA Handbook (7^th Edition):

Nader, Guilherme Pedreira de F. “FAK and SRC Kinases Maintain Integrin Activation During Endocytic Recycling to Polarize Adhesion Formation.” 2015. Web. 27 Feb 2021.

Vancouver:

Nader GPdF. FAK and SRC Kinases Maintain Integrin Activation During Endocytic Recycling to Polarize Adhesion Formation. [Internet] [Doctoral dissertation]. Columbia University; 2015. [cited 2021 Feb 27]. Available from: https://doi.org/10.7916/D8TH8KG0.

Council of Science Editors:

Nader GPdF. FAK and SRC Kinases Maintain Integrin Activation During Endocytic Recycling to Polarize Adhesion Formation. [Doctoral Dissertation]. Columbia University; 2015. Available from: https://doi.org/10.7916/D8TH8KG0

Tartu University

10. Lobanovskaya, Natalia. The role of PSA-NCAM in the survival of retinal ganglion cells .

Degree: 2020, Tartu University

URL: http://hdl.handle.net/10062/66931

► Närviraku adhesioonimolekul (NCAM) on glükoproteiin, mis kuulub immunoglobuliinide superperekonda. Kolm peamist NCAMi isovormi on jaotatud molekulmassi alusel (NCAM-180, NCAM-140, NCAM-120) ning need erinevad üksteisest rakumembraani… (more)

▼ Närviraku adhesioonimolekul (NCAM) on glükoproteiin, mis kuulub immunoglobuliinide superperekonda. Kolm peamist NCAMi isovormi on jaotatud molekulmassi alusel (NCAM-180, NCAM-140, NCAM-120) ning need erinevad üksteisest rakumembraani läbiva domeeni poolest. Närviraku adhesioonimolekulide peamine roll on närvirakkude vaheliste kontaktide loomine ja nende stabiliseerimine. Polüsiaalhappe (PSA) seondumine NCAMi viienda immunoglobuliini domeeni külge toimub polüsialüültransferaas II (ST8SiaII) ja IV (ST8SiaIV) vahendusel, ning selle tulemusena väheneb rakkudevaheline adhesioon. Lisaks on näidatud, et PSA-NCAM ei mõjuta mitte üksnes rakkudevahelisi adhesiivseid omandusi, vaid sellel on oluline roll ka protsessides, mille kaudu reguleeritakse rakkude elulemust, proliferatsiooni, diferentseerumist, migratsiooni, aksonite väljakasvu ning sünaptilist plastilisust. PSA-NCAMi leidub valdavalt kesknärvisüsteemi neuronitel ning gliiarakkudel ja olles närvirakkudevahelise struktuurse dünaamilisuse vahendaja, omab ta olulist rolli aju plastilisuse regulatsioonis nii arenevas ajukoes kui ka täiskasvanueas. Silma võrkkestas esineb PSA-NCAMi täiskasvanueas kõige rohkem Mülleri rakkudel ja astrotsüütidel ganglionirakkude (RGC) juures. Silma võrkkest koosneb mitmetest erineva funktsiooniga rakukihtidest, millest ühe kihi moodustavad ganglionirakud. Selles kihis paiknevad RGCde kehad, mille aksonid moodustavad nägemisnärvi. On näidatud, et silma võrkkesta PSA-NCAM võib mõjutada RGC elulemust, kuid milline on PSA-NCAMi täpne roll täiskasvanueas silma võrkkesta funktsiooni tagamisel, pole teada. Töö eesmärgid: 1. Tuvastada, kas NCAM, ST8SiaII, ST8SiaIV puudulikel hiirtel ja endosialidaas-N-i (Endo-N) indutseeritud PSA defitsiit metsiktüüpi hiirtel esinevad muutused PSA-NCAMi ekspressionis ja silma võrkkesta RGCde arvus. 2. Selgitada, kas ja kuidas mõjutab NCAM-/-, ST8SiaII-/-, ST8SiaIV-/- või Endo-N-iga tekitatud PSA kadu silma võrkkesta RGCde elulemust neurotoksiini kaiinhappe intravitreaalse manustamise järgselt. 3. Selgitada, millise mehhanismi vahendusel väheneb PSA-NCAMi tase ning tekib RGCde degeneratsioon kaiinhappe intravitreaalse manustamise järgselt. 4. Teha kindlaks PSA-NCAMi ja maatriksi metalloproteinaas-9 (MMP-9) roll RGCde elulemusele hiire streptosototsiiniga indutseeritud diabeedi mudelis. Töö tulemused: 1. Antud töö tulemused näitasid, et vastsündinud ST8SiaII-/- ja ST8SiaIV-/- hiirtel on PSA-NCAMi ekspressioon oluliselt vähenenud, kuid täiskasvanud hiirtel ekspressioonis muutusi ei täheldatud. NCAM-/- hiirtel PSA-NCAMi ei leitud. Tuvastati, et NCAM-/- hiirtel on RGCde arv oluliselt suurenenud, vastupidiselt ST8SiaII-/- hiirtele, kellel RGCde arv on vähenenud, kuid ST8SiaIV-/- hiirtel RGCde arvus muutusi ei esinenud. Samuti selgus, et PSA eemaldamine NCAMilt Endo-N-iga ei mõjutanud RGCde elulemust. 2. Ilmnes, et ST8SiaII-, ST8SiaIV- või NCAM-defitsiitsetel loomadel ei mõjutanud kaiinhappe poolt põhjustatud toksilisus RGCde elulemust, mille põhjuseks võib olla olemasolevate sialüültransferaaside… Advisors/Committee Members: Zharkovsky, Alexander, juhendaja (advisor).

Subjects/Keywords: retina; astrocytes; ganglia; cell adhesion molecules; cell surface proteins; adhesion; neurotoxin; metalloproteinases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lobanovskaya, N. (2020). The role of PSA-NCAM in the survival of retinal ganglion cells . (Thesis). Tartu University. Retrieved from http://hdl.handle.net/10062/66931

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lobanovskaya, Natalia. “The role of PSA-NCAM in the survival of retinal ganglion cells .” 2020. Thesis, Tartu University. Accessed February 27, 2021. http://hdl.handle.net/10062/66931.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lobanovskaya, Natalia. “The role of PSA-NCAM in the survival of retinal ganglion cells .” 2020. Web. 27 Feb 2021.

Vancouver:

Lobanovskaya N. The role of PSA-NCAM in the survival of retinal ganglion cells . [Internet] [Thesis]. Tartu University; 2020. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10062/66931.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lobanovskaya N. The role of PSA-NCAM in the survival of retinal ganglion cells . [Thesis]. Tartu University; 2020. Available from: http://hdl.handle.net/10062/66931

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Youngstown State University

11. Malleske, Daniel T. Maintaining Neutrophils at Low Temperature During in Vitro Manipulation Improves Accuracy of Cell Adhesion Molecule Analysis.

Degree: MSin Biological Sciences, Department of Biological Sciences and Chemistry, 2000, Youngstown State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ysu999634332

► Cell adhesion molecules play crucial roles in many disease entities including the adult respiratory distress syndrome. Understanding their function and regulation depends on accurate methods… (more)

Subjects/Keywords: Biology, Cell; cell adhesion molecules

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APA (6^th Edition):

Malleske, D. T. (2000). Maintaining Neutrophils at Low Temperature During in Vitro Manipulation Improves Accuracy of Cell Adhesion Molecule Analysis. (Masters Thesis). Youngstown State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ysu999634332

Chicago Manual of Style (16^th Edition):

Malleske, Daniel T. “Maintaining Neutrophils at Low Temperature During in Vitro Manipulation Improves Accuracy of Cell Adhesion Molecule Analysis.” 2000. Masters Thesis, Youngstown State University. Accessed February 27, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ysu999634332.

MLA Handbook (7^th Edition):

Malleske, Daniel T. “Maintaining Neutrophils at Low Temperature During in Vitro Manipulation Improves Accuracy of Cell Adhesion Molecule Analysis.” 2000. Web. 27 Feb 2021.

Vancouver:

Malleske DT. Maintaining Neutrophils at Low Temperature During in Vitro Manipulation Improves Accuracy of Cell Adhesion Molecule Analysis. [Internet] [Masters thesis]. Youngstown State University; 2000. [cited 2021 Feb 27]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ysu999634332.

Council of Science Editors:

Malleske DT. Maintaining Neutrophils at Low Temperature During in Vitro Manipulation Improves Accuracy of Cell Adhesion Molecule Analysis. [Masters Thesis]. Youngstown State University; 2000. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ysu999634332

University of Alberta

12. Abuetabh, Yasser H. Investigating The Role Of Fibrocystin/Polyductin In Cholangiocarcinoma.

Degree: MS, Medical Sciences- Laboratory Medicine and Pathology, 2013, University of Alberta

URL: https://era.library.ualberta.ca/files/q524jp35t

► Cholangiocarcinoma (CCA) represents a very devastating liver neoplasm, whose incidence is increasing worldwide. CCA is often diagnosed in its late stages, and the treatment options… (more)

Subjects/Keywords: Fibrocystin/polyductin; Bile duct cancer; Cell adhesion molecules

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APA (6^th Edition):

Abuetabh, Y. H. (2013). Investigating The Role Of Fibrocystin/Polyductin In Cholangiocarcinoma. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/q524jp35t

Chicago Manual of Style (16^th Edition):

Abuetabh, Yasser H. “Investigating The Role Of Fibrocystin/Polyductin In Cholangiocarcinoma.” 2013. Masters Thesis, University of Alberta. Accessed February 27, 2021. https://era.library.ualberta.ca/files/q524jp35t.

MLA Handbook (7^th Edition):

Abuetabh, Yasser H. “Investigating The Role Of Fibrocystin/Polyductin In Cholangiocarcinoma.” 2013. Web. 27 Feb 2021.

Vancouver:

Abuetabh YH. Investigating The Role Of Fibrocystin/Polyductin In Cholangiocarcinoma. [Internet] [Masters thesis]. University of Alberta; 2013. [cited 2021 Feb 27]. Available from: https://era.library.ualberta.ca/files/q524jp35t.

Council of Science Editors:

Abuetabh YH. Investigating The Role Of Fibrocystin/Polyductin In Cholangiocarcinoma. [Masters Thesis]. University of Alberta; 2013. Available from: https://era.library.ualberta.ca/files/q524jp35t

Freie Universität Berlin

13. Hasan, Amr. Role of neuronal cell adhesion molecules in regulating filopodial dynamics and synapse formation in the drosophila visual system.

Degree: 2020, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-27789

► Gehirne von höheren Tieren bestehen aus einem komplexen Netzwerk aus vielen verschalteten Neuronen. Die Entwicklungsprozesse, die an der Verschaltung eines funktionalen Gehirns beteiligt sind, werden… (more)

▼ Gehirne von höheren Tieren bestehen aus einem komplexen Netzwerk aus vielen verschalteten Neuronen. Die Entwicklungsprozesse, die an der Verschaltung eines funktionalen Gehirns beteiligt sind, werden durch eine Vielzahl von Proteinfamilien kontrolliert. Diese steuern neuronales Pathfinding und Targeting, die Spezifizierung synaptischer Partner, und Synapsenbildung. Ich untersuchte die Rolle von Zelladhäsionmolekülen (CAMs) im regulierenden R7-Photorezeptorterminal und die Dynamik von Filopodien und deren Effekt auf die Synapsenbildung. Dazu verwendete ich das visuelle System der Fruchtfliege, sowie Live Imaging von sich entwickelnden Photorezeptoren in intakten Drosophila-Gehirnen in ex vivo Kulturen. Ich untersuchte die zwei Tyrosinphosphatasen (PTPs), Lar und PTP69D, und das Fliegenhomolog des Amyloid-Precursor-Protein (APP) APP-like (APPL). Außerdem untersuchte ich die Funktion von Neurexin-1 (Nrx), wessen Rolle in Photorezeptor-Targeting und -Synapsenbildung bisher nicht bekannt war. Lar und das damit interagierende Protein, Liprin-α, stabilisierten R7-Terminale in ihrer Zielschicht. Ihr Funktionsverlust in R7 führte zu Veränderungen in der Filopodiendynamik und beeinflusste die Stabilität der Bulbous Tips und Synapsenformation. Lar und Liprin-α steigerten die Stabilität der Bulbous Tips, indem sie die Mikrotubuli stabilisierten, und somit eine mechanische Stütze für prä-postsynaptische Kontakte bot, wodurch die Synapsenbildung erleichtert wurde. Um diese Hypothese zu testen reduzierte ich due Aktin Polymerisation durch Knock-Down von Chronophin (dCIN) was die Filopodienstabilität erhöhte und dadurch zu mehr Synapsen führte. Der Verlust von ptp69d führte zu einer sehr milden R7-Rücknahme und einem Filopodiendefekt ohne Effekt auf die Bulbous Tip-Dynamik und Synapsenbildung. Das bestätigt die frühere Vermutung, dass die ausgeprägten Funktionen von PTP69D in R7 nicht zu Lar redundant sind. In nrx-mutierten Photorezeptoren wurde kein R7 targeting Defekt bemerkt, dafür aber erhöhte synaptische Transmission. nrx-mutierte R7 bildeten keine stabilen Bulbous Tips aus, bildeten jedoch Synapsen mit mehr und abnormen postsynaptischen Partnern. Dies suggeriert, dass Nrx als ein negativer Regulator für Synapsenbildung in Photorezeptoren wirkt. Schließlich konnte gezeigt werden, dass der subtile Retraktion-Phänotyp in appl-mutierten R7 unabhängig von APPL-Funktion in Photorezeptoren ist. Außerdem zeigten Experimente an den intra- und extrazellulären Fragmenten der proteolytischen Spaltungsprodukte von APPL, dass sie in unterschiedlichen Stadien der sich entwickelnden Neuronen verschieden transportiert werden. Das intrazelluläre Fragment lokalisierte sich in den Axonterminalien von R7, während das extrazelluläre Fragment aus den Photorezeptoren ausgeschieden und von Gliazellen in Regionen der Hirnrinde aufgenommen wurde, wo es schließlich den endolysosomalen Transport spezifisch beeinflusste. Diese Studie stellt die vorgeschlagene Funktion der getesteten CAMs als ´guidance` Moleküle in Frage. Live Imaging zeigte, dass… Advisors/Committee Members: male (gender), Hiesinger, Peter Robin (firstReferee), Wernet, Mathias (furtherReferee).

Subjects/Keywords: Drosophila; Visual system; Cell adhesion molecules; ddc:500; ddc:570

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hasan, A. (2020). Role of neuronal cell adhesion molecules in regulating filopodial dynamics and synapse formation in the drosophila visual system. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-27789

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hasan, Amr. “Role of neuronal cell adhesion molecules in regulating filopodial dynamics and synapse formation in the drosophila visual system.” 2020. Thesis, Freie Universität Berlin. Accessed February 27, 2021. http://dx.doi.org/10.17169/refubium-27789.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hasan, Amr. “Role of neuronal cell adhesion molecules in regulating filopodial dynamics and synapse formation in the drosophila visual system.” 2020. Web. 27 Feb 2021.

Vancouver:

Hasan A. Role of neuronal cell adhesion molecules in regulating filopodial dynamics and synapse formation in the drosophila visual system. [Internet] [Thesis]. Freie Universität Berlin; 2020. [cited 2021 Feb 27]. Available from: http://dx.doi.org/10.17169/refubium-27789.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hasan A. Role of neuronal cell adhesion molecules in regulating filopodial dynamics and synapse formation in the drosophila visual system. [Thesis]. Freie Universität Berlin; 2020. Available from: http://dx.doi.org/10.17169/refubium-27789

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

14. Wang, Yuxiao. Structural Mechanisms of Semaphorin/Plexin Signaling.

Degree: 2014, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/3578

► Plexins are cell surface receptors that bind to their ligand semaphorins and transduce signals for regulating processes including neuronal development, angiogenesis and immune response. Deregulations… (more)

Subjects/Keywords: Cell Adhesion Molecules; Nerve Tissue Proteins; rap GTP-Binding Proteins

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APA (6^th Edition):

Wang, Y. (2014). Structural Mechanisms of Semaphorin/Plexin Signaling. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/3578

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wang, Yuxiao. “Structural Mechanisms of Semaphorin/Plexin Signaling.” 2014. Thesis, University of Texas Southwestern Medical Center. Accessed February 27, 2021. http://hdl.handle.net/2152.5/3578.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wang, Yuxiao. “Structural Mechanisms of Semaphorin/Plexin Signaling.” 2014. Web. 27 Feb 2021.

Vancouver:

Wang Y. Structural Mechanisms of Semaphorin/Plexin Signaling. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2014. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2152.5/3578.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wang Y. Structural Mechanisms of Semaphorin/Plexin Signaling. [Thesis]. University of Texas Southwestern Medical Center; 2014. Available from: http://hdl.handle.net/2152.5/3578

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Iowa State University

15. Dettmer, Michelle Elise. The effect of soy protein beverages on serum cell adhesion molecule concentrations in prehypertensive/stage 1 hypertensive individuals.

Degree: 2011, Iowa State University

URL: https://lib.dr.iastate.edu/etd/11995

► Background and Aims: Prehypertensive and hypertensive individuals are at an increased risk of atherosclerotic cardiovascular disease. The role of hypertension in endothelial dysfunction and increased… (more)

▼ Background and Aims: Prehypertensive and hypertensive individuals are at an increased risk of atherosclerotic cardiovascular disease. The role of hypertension in endothelial dysfunction and increased cell adhesion molecule (CAM) expression may lead to atherosclerotic progression. Soy protein and isoflavones have been shown to favorably alter cardiovascular disease risk factors. The aim of this study was to determine the effect of daily cow's milk compared with soy beverage prepared from whole soy bean (WSB) or soy protein isolate (SPI) on soluble cell adhesion molecules. Methods: We enrolled healthy prehypertensive/Stage 1 hypertensive men (n=60, aged 18 - 63 yr) and premenopausal women (n=8, aged 20 - 48 yr) and randomized them to one of three beverage groups for 8 weeks of treatment: cow's milk (600 mL/d), soy beverage (840 mL/d) prepared from SPI (30.1 mg total isoflavones/d [aglycone form]) or prepared from WSB (91.4 mg total isoflavones/d [aglycone form]). We measured soluble vascular cell adhesion molecule-1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), and endothelial-leukocyte adhesion molecule-1 (E-selectin) at baseline and week 8. Results: Treatment did not alter soluble CAM concentrations. Time had an effect on VCAM-1 (-9%, P = 0.01) and E-selectin (+4%, P = 0.01) but not ICAM-1 (+5%, P=0.86). Gender also had a significant effect on ICAM-1 (P=0.0037), whereas gender did not reach significance for E-selectin (P=0.067) or VCAM-1 (P=0.16). Men had higher circulating concentrations of ICAM-1 and E-selectin, respectively, at both baseline (P = 0.0071, P = 0.049) and week 8 (P = 0.0054, P = 0.038) than women. ICAM concentrations were not significantly different between prehypertensive and hypertensive participants. Conclusion: Prehypertensive/Stage I hypertensive individuals who consumed either cow's milk or soy beverages (prepared from WSB or SPI) for 8 weeks daily did not show any change in soluble CAM concentrations. Consequently, we cannot suggest that daily intake of either cow's milk or soy protein beverages improves circulating CAM concentrations and hence risk of atherosclerotic CVD in these individuals.

Subjects/Keywords: Cardiovascular disease risk; Cell adhesion molecules; Hypertension; Isoflavones; Soy Protein; Nutrition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dettmer, M. E. (2011). The effect of soy protein beverages on serum cell adhesion molecule concentrations in prehypertensive/stage 1 hypertensive individuals. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/11995

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dettmer, Michelle Elise. “The effect of soy protein beverages on serum cell adhesion molecule concentrations in prehypertensive/stage 1 hypertensive individuals.” 2011. Thesis, Iowa State University. Accessed February 27, 2021. https://lib.dr.iastate.edu/etd/11995.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dettmer, Michelle Elise. “The effect of soy protein beverages on serum cell adhesion molecule concentrations in prehypertensive/stage 1 hypertensive individuals.” 2011. Web. 27 Feb 2021.

Vancouver:

Dettmer ME. The effect of soy protein beverages on serum cell adhesion molecule concentrations in prehypertensive/stage 1 hypertensive individuals. [Internet] [Thesis]. Iowa State University; 2011. [cited 2021 Feb 27]. Available from: https://lib.dr.iastate.edu/etd/11995.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dettmer ME. The effect of soy protein beverages on serum cell adhesion molecule concentrations in prehypertensive/stage 1 hypertensive individuals. [Thesis]. Iowa State University; 2011. Available from: https://lib.dr.iastate.edu/etd/11995

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

16. Grooby, Warwick L. Studies of endothelial and leukocyte cell adhesion molecules in renal transplantation / by Warwick L. Grooby.

Degree: 1996, University of Adelaide

URL: http://hdl.handle.net/2440/18890

► This thesis examines the expression of cell adhesion molecules on both endothelial cells (ECs) and circulating leukocytes, and investigates the role of these molecules in… (more)

Subjects/Keywords: Cell adhesion molecules.; Kidneys Transplantation.

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APA (6^th Edition):

Grooby, W. L. (1996). Studies of endothelial and leukocyte cell adhesion molecules in renal transplantation / by Warwick L. Grooby. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/18890

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grooby, Warwick L. “Studies of endothelial and leukocyte cell adhesion molecules in renal transplantation / by Warwick L. Grooby.” 1996. Thesis, University of Adelaide. Accessed February 27, 2021. http://hdl.handle.net/2440/18890.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grooby, Warwick L. “Studies of endothelial and leukocyte cell adhesion molecules in renal transplantation / by Warwick L. Grooby.” 1996. Web. 27 Feb 2021.

Vancouver:

Grooby WL. Studies of endothelial and leukocyte cell adhesion molecules in renal transplantation / by Warwick L. Grooby. [Internet] [Thesis]. University of Adelaide; 1996. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2440/18890.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grooby WL. Studies of endothelial and leukocyte cell adhesion molecules in renal transplantation / by Warwick L. Grooby. [Thesis]. University of Adelaide; 1996. Available from: http://hdl.handle.net/2440/18890

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

17. Zhang, Xingqi, 1960-. Distribution and function of a CD36 orthologue defined by monoclonal antibody UA009 in the rat / by Xingqi Zhang.

Degree: 2001, University of Adelaide

URL: http://hdl.handle.net/2440/19896

Characterises the antigen recognized by mAb UA009 and investigates whether it is an endothelial adhesion marker. The identification of a CD36-like molecule led to targeted histological studies on the expression of the molecule in specific tissues of interest. Advisors/Committee Members: Dept. of Microbiology and Immunology (school).

Subjects/Keywords: Cell adhesion molecules; Monoclonal antibodies.

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APA (6^th Edition):

Zhang, Xingqi, 1. (2001). Distribution and function of a CD36 orthologue defined by monoclonal antibody UA009 in the rat / by Xingqi Zhang. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/19896

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhang, Xingqi, 1960-. “Distribution and function of a CD36 orthologue defined by monoclonal antibody UA009 in the rat / by Xingqi Zhang.” 2001. Thesis, University of Adelaide. Accessed February 27, 2021. http://hdl.handle.net/2440/19896.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhang, Xingqi, 1960-. “Distribution and function of a CD36 orthologue defined by monoclonal antibody UA009 in the rat / by Xingqi Zhang.” 2001. Web. 27 Feb 2021.

Vancouver:

Zhang, Xingqi 1. Distribution and function of a CD36 orthologue defined by monoclonal antibody UA009 in the rat / by Xingqi Zhang. [Internet] [Thesis]. University of Adelaide; 2001. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2440/19896.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhang, Xingqi 1. Distribution and function of a CD36 orthologue defined by monoclonal antibody UA009 in the rat / by Xingqi Zhang. [Thesis]. University of Adelaide; 2001. Available from: http://hdl.handle.net/2440/19896

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

18. Li, Hang-wun. Expression of E-cadherin and Beta-catenin in trophoblastic tissue in normal and pathological pregnancies.

Degree: 2000, University of Hong Kong

URL: http://hdl.handle.net/10722/28370

Subjects/Keywords: Cell adhesion molecules.; Pregnancy.; Trophoblast.

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APA (6^th Edition):

Li, H. (2000). Expression of E-cadherin and Beta-catenin in trophoblastic tissue in normal and pathological pregnancies. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/28370

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Hang-wun. “Expression of E-cadherin and Beta-catenin in trophoblastic tissue in normal and pathological pregnancies.” 2000. Thesis, University of Hong Kong. Accessed February 27, 2021. http://hdl.handle.net/10722/28370.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Hang-wun. “Expression of E-cadherin and Beta-catenin in trophoblastic tissue in normal and pathological pregnancies.” 2000. Web. 27 Feb 2021.

Vancouver:

Li H. Expression of E-cadherin and Beta-catenin in trophoblastic tissue in normal and pathological pregnancies. [Internet] [Thesis]. University of Hong Kong; 2000. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10722/28370.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li H. Expression of E-cadherin and Beta-catenin in trophoblastic tissue in normal and pathological pregnancies. [Thesis]. University of Hong Kong; 2000. Available from: http://hdl.handle.net/10722/28370

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of British Columbia

19. Pfeiffer, David Carl. Actin associated intercellular adhesion junctions in the mammalian testis.

Degree: MS- MSc, Anatomy, Cell Biology and Physiology, 1990, University of British Columbia

URL: http://hdl.handle.net/2429/29753

► In the mammalian seminiferous epithelium, the cytoplasm of Sertoli cells adjacent to sites of intercellular attachment exhibits unique structural attributes. In each of these regions,… (more)

▼ In the mammalian seminiferous epithelium, the cytoplasm of Sertoli cells adjacent to sites of intercellular attachment exhibits unique structural attributes. In each of these regions, a layer of hexagonally packed actin filaments lies situated between a cistern of endoplasmic reticulum and the plasma membrane. The filament layer together with the reticulum and adjacent plasma membrane are collectively termed an "ectoplasmic specialization". Ectoplasmic specializations occur in apical Sertoli cell regions at sites of attachment to spermatids and basally at sites of attachment to adjacent Sertoli cells. Ectoplasmic specializations have been hypothesized to be actin associated intercellular adhesion junctions. If this is true, molecular components that characterize actin associated adhesion junctions in general should be present in ectoplasmic specializations. In this study, I tested this prediction in two ways. First, I investigated whether or not the protein vinculin is co-distributed with actin filament bundles in ectoplasmic specializations of the ground squirrel. Second, I immunologically probed ectoplasmic specializations for three cell adhesion molecules (CAMs) that are commonly found in regions of intercellular adhesion in other tissues. My results indicate that vinculin is co-distributed with actin in Sertoli cell regions attached to spermatids. These data are consistent with the conclusion that vinculin is a component of ectoplasmic specializations and, therefore, with the hypothesis that the latter structures are a form of actin associated adhesion junction. Experiments using probes for the CAMs indicate that E-cadherin, A-CAM and N-CAM are probably not present in ectoplasmic specializations. The adhesion molecule at these sites may be a different member of the known CAMs or an as yet unidentified CAM. Based on data presented here and elsewhere indicating that ectoplasmic specializations are a form of actin associated adhesion junction, I describe the elaborate changes that occur in constituent filament bundles at sites of attachment to spermatids of the ground squirrel and interprete them in the context of the adhesion hypothesis. During the course of the co-localization studies described above, I observed that vinculin and actin are co-distributed at certain sites of intercellular attachment between interstitial cells of Leydig in the ground squirrel testis. Moreover, at the ultrastructural level I found these sites correspond to microfilament rich junction regions. These observations are consistent with the conclusion that actin associated intercellular adhesion junctions exist between interstitial cells of Leydig in the ground squirrel testis.

Subjects/Keywords: Actins; Cell Adhesion Molecules; Testis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pfeiffer, D. C. (1990). Actin associated intercellular adhesion junctions in the mammalian testis. (Masters Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/29753

Chicago Manual of Style (16^th Edition):

Pfeiffer, David Carl. “Actin associated intercellular adhesion junctions in the mammalian testis.” 1990. Masters Thesis, University of British Columbia. Accessed February 27, 2021. http://hdl.handle.net/2429/29753.

MLA Handbook (7^th Edition):

Pfeiffer, David Carl. “Actin associated intercellular adhesion junctions in the mammalian testis.” 1990. Web. 27 Feb 2021.

Vancouver:

Pfeiffer DC. Actin associated intercellular adhesion junctions in the mammalian testis. [Internet] [Masters thesis]. University of British Columbia; 1990. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2429/29753.

Council of Science Editors:

Pfeiffer DC. Actin associated intercellular adhesion junctions in the mammalian testis. [Masters Thesis]. University of British Columbia; 1990. Available from: http://hdl.handle.net/2429/29753

Universidade do Rio Grande do Sul

20. Flores, Anacláudia Pereira Costa. Avaliação das cinases de adesão focal (FAKS) em diferentes zonas no carcinoma espinocelular de cabeça e pescoço e sua relação com TNM, graduação histopatológica e evolução.

Degree: 2015, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/128188

►

O carcinoma espinocelular (CEC) de cabeça e pescoço é uma neoplasia maligna que implica em baixas taxas de sobrevida e prognóstico desfavorável. A perda de… (more)

▼

O carcinoma espinocelular (CEC) de cabeça e pescoço é uma neoplasia maligna que implica em baixas taxas de sobrevida e prognóstico desfavorável. A perda de adesão do epitélio e a migração celular são processos biológicos envolvidos na carcinogênese. O objetivo desse estudo foi descrever o padrão de expressão da molécula cinase de adesão focal (FAK) e suas formas fosforiladas, FAK-Tyr576 e FAK-Tyr925, em amostras de CEC no centro do tumor (CT) e zona de invasão (ZI) e no tecido epitelial não neoplásico adjacente a estes tumores (EA). De acordo com a graduação histopatológica, 48,1% do total das amostras de CEC são de grau moderado. Segundo o sistema pTNM, 62,9% eram T1 e T2, 64,8% não apresentaram metástase regional e não houve metástase à distância. O tempo máximo de acompanhamento foi de 5,9 anos e obteve-se a proservação final de 46 dos 54 pacientes, onde foi observado que 58,1% apresentaram boa evolução e 41,9% exibiram evolução ruim. A média em anos para que os pacientes obtivessem o status de evolução ruim foi de 5,01. Quanto ao estadiamento clínico, houve maior imunomarcação no estádio IVa quando comparado ao estádio II no EA da FAK Tyr-576 e ocorreu maior expressão no estádio IVb quando comparado ao estádio I no CT da FAK Tyr-576. Os pacientes que apresentaram evolução ruim após o período máximo de acompanhamento tiveram alta expressão no EA e na ZI da FAK Tyr-576 e no CT da FAK Tyr-925. Na ZI, o aumento de expressão da FAK está associado ao aumento da expressão da FAK Tyr-576. À medida que há aumento da expressão no EA há aumento da expressão na ZI na FAK Tyr-576. E quando há aumento da expressão no EA há aumento da marcação na ZI na FAK Tyr-925. Apesar do papel de todas as FAKs fosforiladas não estar claro, mas sabendo-se que são essas FAKs que estão ativas no câncer, a partir dos dados do presente trabalho pode-se sugerir que a avaliação da marcação FAK Tyr -576 no EA, no CT e na ZI venha a fazer parte da rotina no diagnóstico histopatológico e das margens da peça operatória, como norteadores da conduta terapêutica e do protocolo de acompanhamento.

Squamous cell carcinoma (SCC) of the head and neck is a malignant neoplasm that implies low rates of survival and poor prognosis. The loss of adhesion and cell migration are biological processes involved in carcinogenesis. The aim of this study was to describe the pattern of expression of focal adhesion kinase molecule (FAK) and its phosphorylated forms, FAK-Tyr576, FAK-Tyr925, in SCC samples in the center of the tumor (CT) and invasion zone (ZI) and non-neoplastic epithelial tissue adjacent to these tumors (EA). According to histopathological grading, 48,1% of SCC samples are moderate. According to the system pTNM, 62,9% were T1 and T2, 64.8%, had no regional metastasis and no distant metastasis. The maximum time of follow up was 5,9 years and was obtained as the final proservation 46 of 54 patients, where it was observed that 58,1% of patients had good prognosis and 41,9% of patients had poor prognosis. The average years for patients to obtain the poor…

Advisors/Committee Members: Sant'Ana Filho, Manoel.

Subjects/Keywords: Carcinoma de células escamosas; Cell migration assays; Neoplasm metastasis; Neoplasias de cabeça e pescoço; Cell adhesion; Cell adhesion molecules; FAK

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Flores, A. P. C. (2015). Avaliação das cinases de adesão focal (FAKS) em diferentes zonas no carcinoma espinocelular de cabeça e pescoço e sua relação com TNM, graduação histopatológica e evolução. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/128188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Flores, Anacláudia Pereira Costa. “Avaliação das cinases de adesão focal (FAKS) em diferentes zonas no carcinoma espinocelular de cabeça e pescoço e sua relação com TNM, graduação histopatológica e evolução.” 2015. Thesis, Universidade do Rio Grande do Sul. Accessed February 27, 2021. http://hdl.handle.net/10183/128188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Flores, Anacláudia Pereira Costa. “Avaliação das cinases de adesão focal (FAKS) em diferentes zonas no carcinoma espinocelular de cabeça e pescoço e sua relação com TNM, graduação histopatológica e evolução.” 2015. Web. 27 Feb 2021.

Vancouver:

Flores APC. Avaliação das cinases de adesão focal (FAKS) em diferentes zonas no carcinoma espinocelular de cabeça e pescoço e sua relação com TNM, graduação histopatológica e evolução. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2015. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10183/128188.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Flores APC. Avaliação das cinases de adesão focal (FAKS) em diferentes zonas no carcinoma espinocelular de cabeça e pescoço e sua relação com TNM, graduação histopatológica e evolução. [Thesis]. Universidade do Rio Grande do Sul; 2015. Available from: http://hdl.handle.net/10183/128188

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

21. Kuo, Yi-Chun. Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective.

Degree: 2017, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/7739

► The Semaphorin-Plexin signaling is important for regulating axon guidance. Binding of Semaphorin to the Plexin receptor induces the dimerization of Plexin and stimulates its cytoplasmic… (more)

▼ The Semaphorin-Plexin signaling is important for regulating axon guidance. Binding of Semaphorin to the Plexin receptor induces the dimerization of Plexin and stimulates its cytoplasmic GAP activity towards Rap, resulting in cytoskeleton re-organization. The growth cone of an axon then turns around, which ultimately leads to the repulsive guidance of the axon. Structural studies by our laboratory and others have revealed how the RapGAP activity of Plexin cytoplasmic region is stimulated by dimerization, how the Semaphorin ligand interacts with Plexin ectodomain, and how extracellular domains prevent Plexin from premature activation. Several downstream effectors interacting with Plexin cytoplasmic domain were found; however, the molecular mechanisms by which these effectors regulate Plexin signaling remain largely unknown. Our laboratory was interested in one of the effectors named FARP. Previous studies in our laboratory determined the crystal structures of the functional units of FARP1 and FARP2 but failed to detect any GEF activity in vitro. A recent screening with yeast two-hybrid identified a RhoGTPase, Rif, as a novel interacting protein for FARP1. To investigate how Rif/FARP1 interaction is involved in Plexin signaling, I determined the crystal structure of Rif-bound FARP1. This complex structure explains the functional roles that FARP1 and Rif might exert in dendritic spine formation and neurite outgrowth. Also, the N-terminal FERM domain of FARPs is known to interact with the cytoplasmic domain of Plexin. To interrogate how FERM interacts with Plexin and how this interaction might regulate Plexin signaling, I characterized the interaction of FERM with Plexin both biophysically and biochemically. The last question that I attempted to address in this dissertation is how a RhoGTPase, RhoD, inhibits activation of Plexin. RhoD was known for its remarkable inhibitory effect on Plexin signaling presumably through binding to the defined RhoGTPase binding domain of Plexin. The structure of Rac1 or Rnd1 in complex with Plexin did not explain how this binding regulates Plexin activity. I solved the crystal structure of the RhoD/Plexin complex. Modeling of this structure with that of Plexin active dimer in the context of the plasma membrane reveals a mechanism by which RhoD inhibits Plexin activation. Structure studies in this dissertation added another layer of comprehension on how the Semaphorin-Plexin signaling is regulated. Advisors/Committee Members: Albanesi, Joseph P., Huang, Jun-Shen, Rizo-Rey, José, Sternweis, Paul C..

Subjects/Keywords: Cell Adhesion Molecules; Nerve Tissue Proteins; Receptors, Cell Surface; rho GTP-Binding Proteins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kuo, Y. (2017). Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/7739

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kuo, Yi-Chun. “Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective.” 2017. Thesis, University of Texas Southwestern Medical Center. Accessed February 27, 2021. http://hdl.handle.net/2152.5/7739.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kuo, Yi-Chun. “Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective.” 2017. Web. 27 Feb 2021.

Vancouver:

Kuo Y. Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2017. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/2152.5/7739.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kuo Y. Dissecting the Function of FARP1 and Rho GTPases in Semaphorin-Plexin Signaling: Structural Perspective. [Thesis]. University of Texas Southwestern Medical Center; 2017. Available from: http://hdl.handle.net/2152.5/7739

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

East Carolina University

22. Holt, Andrew W. Vasodilator-stimulated phosphoprotein regulates arterial smooth muscle cell migration.

Degree: PhD, PHD-Physiology, 2016, East Carolina University

URL: http://hdl.handle.net/10342/5999

► Cardiovascular disease (CVD) is a multi-faceted pathology that remains the number one killer of all Americans and people worldwide. Vascular inflammation, endothelial dysfunction, extracellular matrix… (more)

▼ Cardiovascular disease (CVD) is a multi-faceted pathology that remains the number one killer of all Americans and people worldwide. Vascular inflammation, endothelial dysfunction, extracellular matrix imbalance, and arterial smooth muscle (ASM) cell proliferation and migration all contribute to the pathogenesis of occlusive CVD. Important roles for protein kinase signals in controlling aspects of ASM cell migration in the context of CVD are well documented in the scientific literature, and recent findings from our lab and others suggest post-translational modification (PTM) of downstream kinase targets could highlight unique mechanisms and thereby elucidate more precise pharmacotherapeutic targets to combat CVD. In this light, actin-binding vasodilator-stimulated phosphoprotein (VASP) is a critical regulator of adherent cell migration, a readout of protein kinase G (PKG) activity, and a potential attractive candidate for therapeutic intervention. We hypothesized that phosphorylation of VASP on Serine 239 (pVASP.S239) confers the anti-migratory effects of PKG in ASMs. Using in vivo and in vitro models with endogenous and exogenous stimulation of canonical PKG/VASP, we demonstrate the functional ability of this system to attenuate ASM cell migration in the context of CVD. Using site-directed mutagenesis (SDM) and rat cells expressing wild-type VASP, data suggest that pVASP.S239 negates the inhibitory effects of full-length VASP overexpression on cell migration and that this is reversed with a phosphorylation-resistant VASP mutant. Alternate to our hypothesis, these results suggest that pVASP.S239 is not effective in preventing or controlling pathologic ASM cell migration. Importantly however, using SDM along with pharmacologic kinase blockade, data reveal a novel negative feedback loop whereby pVASP.S239 suppresses PKG activity which can be rescued with PKG stimulation. Collectively, using newly developed and advanced techniques for studying cell migration in situ, these findings highlight the importance of VASP and establish the efficacy of PKG in attenuating uncontrolled ASM cell migration independent of pVASP.S239. Clinically, our data demonstrate a potential regulatory element that, with future examination, could lead to potential adjunctive therapies for occlusive vascular diseases involving ASM. Advisors/Committee Members: Tulis, David (committee member).

Subjects/Keywords: PKG; VASP; Cardiovascular Diseases; Cell Adhesion Molecules; Cell Movement; Microfilament Proteins; Myocytes, Smooth Muscle; Phosphoproteins

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Holt, A. W. (2016). Vasodilator-stimulated phosphoprotein regulates arterial smooth muscle cell migration. (Doctoral Dissertation). East Carolina University. Retrieved from http://hdl.handle.net/10342/5999

Chicago Manual of Style (16^th Edition):

Holt, Andrew W. “Vasodilator-stimulated phosphoprotein regulates arterial smooth muscle cell migration.” 2016. Doctoral Dissertation, East Carolina University. Accessed February 27, 2021. http://hdl.handle.net/10342/5999.

MLA Handbook (7^th Edition):

Holt, Andrew W. “Vasodilator-stimulated phosphoprotein regulates arterial smooth muscle cell migration.” 2016. Web. 27 Feb 2021.

Vancouver:

Holt AW. Vasodilator-stimulated phosphoprotein regulates arterial smooth muscle cell migration. [Internet] [Doctoral dissertation]. East Carolina University; 2016. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10342/5999.

Council of Science Editors:

Holt AW. Vasodilator-stimulated phosphoprotein regulates arterial smooth muscle cell migration. [Doctoral Dissertation]. East Carolina University; 2016. Available from: http://hdl.handle.net/10342/5999

NSYSU

23. Hung, Hsuan-ning. Differential gene expression in human placentas from preeclampsia and normal pregnancies.

Degree: Master, Biological Sciences, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729116-161442

► Preeclampsia (PE) incidence in Taiwan is 2-5%, less than the average rate of 5-7% worldwide; however, it is one of the three major causes of… (more)

Subjects/Keywords: Cell adhesion molecules 1; Vascular endothelial growth factor 1; Leukocyte transendothelial migration; Preeclampsia; microarray analysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hung, H. (2016). Differential gene expression in human placentas from preeclampsia and normal pregnancies. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729116-161442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hung, Hsuan-ning. “Differential gene expression in human placentas from preeclampsia and normal pregnancies.” 2016. Thesis, NSYSU. Accessed February 27, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729116-161442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hung, Hsuan-ning. “Differential gene expression in human placentas from preeclampsia and normal pregnancies.” 2016. Web. 27 Feb 2021.

Vancouver:

Hung H. Differential gene expression in human placentas from preeclampsia and normal pregnancies. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Feb 27]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729116-161442.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hung H. Differential gene expression in human placentas from preeclampsia and normal pregnancies. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0729116-161442

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

24. Huang, Chi-Wei. The role of cell adhesion molecules and cerebral perfusion in patients with acute ischemic stroke and mild cognitive impairment.

Degree: PhD, Biological Sciences, 2015, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0804115-041407

► Background and Purposes: Maintaining sufficient blood flow to the brain consistently is important to keep normal brain function. As we know, ischemic stroke is a… (more)

▼ Background and Purposes: Maintaining sufficient blood flow to the brain consistently is important to keep normal brain function. As we know, ischemic stroke is a common disease caused by acute impairment of focal cerebral perfusion due to vessel occlusion. However, attention has recently focused on the adverse effect of chronic cerebral hypoperfusion on brain structural changes and cognitive function. Early neurologic deterioration (END) is frequently observed and related to poor functional outcome in acute ischemic stroke, Cell adhesion molecules (CAMs) have been reported to involve the pathogenesis of cerebral ischemia, however, the association with cerebral perfusion has not been evaluated. In this thesis, Arterial spin labeling (ASL) MRI, a new imaging technique, was used to assess the cerebral perfusion. There were several purposes in this study. (1) To understand the association between perfusion-diffusion (PWI-DWI) mismatch and END in acute stroke. (2) To understand the association between chronic cerebral perfusion and brain structural change in mild cognitive impairment (MCI). (3) To evaluate the impact of CAMs on perfusion-diffusion mismatch in acute stroke and cerebral hypoperfusion in MCI. Material and methods: The study separately enrolled acute stroke patients and patients with MCI. In acute stroke, ASL perfusion MRI was performed within 48 h of symptoms onset to detect PWI-DWI mismatch. National Institutes of Health Stroke Scale (NIHSS) and Barthel index were used to score neurologic deficit and functional impairment at admission, one week and one month after stroke. END was defined as an increase of 2 or more points in NIHSS within one week after stroke onset. Plasma levels of CAMs including VCAM-1, ICAM-1and E-selectin were measured at admission and one week after symptoms onset. In patients with MCI, ASL perfusion was used to quantitate regional cerebral perfusion. Cognitive function was assessed and plasma levels of CAMs were measured at enrollment. Result: 120 patients with acute stroke in cerebral hemisphere were enrolled. There were 65 patients with lacunar stroke and 55 patients with thromboembolic stroke. Patients with PWI-DWI mismatch had higher risk for END in thromboembolic infarct. Higher level of VCAM-1 was independently associated with PWI-DWI mismatch and END in thromboembolic infarct. 110 patients with MCI were enrolled. Cerebral hypoperfusion was associated with cognitive impairment, medial temporal lobe atrophy and increase white matter lesions. The level of VCAM-1 was significant inversely associated with cerebral cortical perfusion especially posterior parietal lobe even after adjusted for cerebrovascular risk factors. Conclusion: The study suggested the importance of cerebral perfusion as the PWI-DWI mismatch associated with END in acute stroke and chronic cerebral hypoperfusion associated with medial temporal lobe atrophy, white matter lesions and cognitive impairment in MCI. CAMs especially VCAM-1 played a role in acute and chronic cerebral hypoperfusion. Advisors/Committee Members: Alice Y.W. Chang (committee member), Chiung-Chih Chang (chair), Yu-Te Lin (chair), Wen-neng Chang (chair), Samuel H. H. Chan (chair).

Subjects/Keywords: stroke; mild cognitive impairment; ASL perfusion MRI; cerebral perfusion; cell adhesion molecules

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Huang, C. (2015). The role of cell adhesion molecules and cerebral perfusion in patients with acute ischemic stroke and mild cognitive impairment. (Doctoral Dissertation). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0804115-041407

Chicago Manual of Style (16^th Edition):

Huang, Chi-Wei. “The role of cell adhesion molecules and cerebral perfusion in patients with acute ischemic stroke and mild cognitive impairment.” 2015. Doctoral Dissertation, NSYSU. Accessed February 27, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0804115-041407.

MLA Handbook (7^th Edition):

Huang, Chi-Wei. “The role of cell adhesion molecules and cerebral perfusion in patients with acute ischemic stroke and mild cognitive impairment.” 2015. Web. 27 Feb 2021.

Vancouver:

Huang C. The role of cell adhesion molecules and cerebral perfusion in patients with acute ischemic stroke and mild cognitive impairment. [Internet] [Doctoral dissertation]. NSYSU; 2015. [cited 2021 Feb 27]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0804115-041407.

Council of Science Editors:

Huang C. The role of cell adhesion molecules and cerebral perfusion in patients with acute ischemic stroke and mild cognitive impairment. [Doctoral Dissertation]. NSYSU; 2015. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0804115-041407

University of Oulu

25. Tahkola, J. (Jenni). Collagen XIII in cardiovascular development and tumorigenesis.

Degree: 2008, University of Oulu

URL: http://urn.fi/urn:isbn:9789514289569

► Abstract Collagen XIII is a type II transmembrane protein, which has a short intracellular domain and a large, mainly collagenous ectodomain. It is located at… (more)

▼ Abstract Collagen XIII is a type II transmembrane protein, which has a short intracellular domain and a large, mainly collagenous ectodomain. It is located at many cell-matrix junctions and in focal adhesions in cultured cells and it has a function in cell adhesive processes. Overexpression of collagen XIII molecules with an 83 amino acid deletion in part of the ectodomain leads to fetal lethality in Col13a1del transgenic mice. Doppler ultrasonography was performed at 12.5 days of gestation on fetuses resulting from heterozygous matings and matings between heterozygous and wild-type mice. Some fetuses had atrioventricular valve regurgitation (AVVR) and all of them were transgene positive. In addition, fetuses had pathological changes in functional parameters. Histological analysis showed the trabeculation of the ventricles to be reduced and the myocardium to be thinner in the fetuses with AVVR. Based on in situ hybridization (ISH), collagen XIII mRNA are normal constituents of these structures. Overexpression of mutant collagen XIII results in mid-gestation cardiac dysfunction in fetuses, and these disturbances in cardiac function may lead to death in utero. The heterozygous mice that were initially of normal appearance had an increased susceptibility to develop B cell lymphomas, which originated in the mesenteric lymph node. Collagen XIII protein was not detected in normal lymph nodes or in the lymphomas. The incidence of lymphomas was higher in conventional conditions than in a specific pathogen-free facility. In addition, the expression of collagen XIII was localized in the intestine and the basement membrane was highly abnormal. These findings suggest that collagen XIII is a critical determinant of lymphanogenesis. Using ISH, antibody staining and RT-PCR techniques collagen XIII expression was analyzed during carcinogenesis in mice and in man. Collagen XIII expression increased during carcinogenesis in mice and in man. In the malignant process collagen XIII mRNA localized in the basal epithelium and in the invasive cells. According to antibody staining malignant invasive cells were positive. Results may reflect the disturbed adhesion of epithelial cells and ECM and that may affect the behaviour of the malignant cells, suggesting that collagen XIII has a significant role in the initiation of the invasion.

Subjects/Keywords: basement membrane; carcinogenesis; cell adhesion molecules; collagen; doppler ultrasonography; heart ventricles; immunity; lymphoma; trabeculation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tahkola, J. (. (2008). Collagen XIII in cardiovascular development and tumorigenesis. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789514289569

Chicago Manual of Style (16^th Edition):

Tahkola, J (Jenni). “Collagen XIII in cardiovascular development and tumorigenesis.” 2008. Doctoral Dissertation, University of Oulu. Accessed February 27, 2021. http://urn.fi/urn:isbn:9789514289569.

MLA Handbook (7^th Edition):

Tahkola, J (Jenni). “Collagen XIII in cardiovascular development and tumorigenesis.” 2008. Web. 27 Feb 2021.

Vancouver:

Tahkola J(. Collagen XIII in cardiovascular development and tumorigenesis. [Internet] [Doctoral dissertation]. University of Oulu; 2008. [cited 2021 Feb 27]. Available from: http://urn.fi/urn:isbn:9789514289569.

Council of Science Editors:

Tahkola J(. Collagen XIII in cardiovascular development and tumorigenesis. [Doctoral Dissertation]. University of Oulu; 2008. Available from: http://urn.fi/urn:isbn:9789514289569

Florida Atlantic University

26. Kakad, Priyanka P. A Novel Role of the Ankyrin-Binding Motif of L1-Type CAM Neuroglian in Nuclear Import and Transcriptional Regulation of Myc.

Degree: 2018, Florida Atlantic University

URL: http://fau.digital.flvc.org/islandora/object/fau:40732

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L1-type cell adhesion molecule (L1CAM) plays an essential role in the development of nervous system and is also highly relevant for the progression of diseases… (more)

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L1-type cell adhesion molecule (L1CAM) plays an essential role in the development of nervous system and is also highly relevant for the progression of diseases such as Alzheimer’s disease, stroke and cancers, some of the leading causes of human mortality. In addition to its canonical role as a plasma membrane protein organizing the cytoskeleton, recent in vitro studies have revealed that transmembrane as well as cytosolic fragments of proteolytically cleaved vertebrate L1CAM translocate to the nucleus and regulate expression of genes involved in DNA post-replication repair, cell cycle control, migration and differentiation. However, little is known about the in vivo function of L1CAM in the adult nervous system. This dissertation research focuses on studying in vivo nuclear translocation and function of L1CAM. Using the Drosophila model system, we first show that the sole Drosophila L1CAM homolog, Neuroglian (Nrg), is proteolytically cleaved by Alzheimer’s associated secretases, similar to L1CAM, and is also translocated to the nucleus in the adult nervous system. Subsequently, we have shown that the deletion of highly conserved Ankyrin binding domain or FIGQY motif disrupts nuclear import. Further experiments have revealed that the nuclear translocation of Nrg is in fact regulated by the phosphorylation of the FIGQY motif. Importantly, our studies also show transgenic expression of full-length Nrg or the intracellular domain of Nrg resulted in increased myc expression, which is associated with increased sensitivity to oxidative stress and reduced life span. On the other hand, deletion of the FIGQY motif or mutations preventing its phosphorylation led to decrease in myc expression. In summary, we have identified a novel role for the highly conserved Ankyrin binding domain in nuclear translocation and transcriptional regulation of the Drosophila myc oncogene, which is of high relevance to neurodegenerative diseases and cancer associated with oxidative stress.

2018

Degree granted: Dissertation (Ph.D.) – Florida Atlantic University, 2018.

Collection: FAU

Advisors/Committee Members: Godenschwege, Tanja A. (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Biological Sciences.

Subjects/Keywords: Cell adhesion molecules.; Myc proteins.; Transcription, Genetic.; Transcription factors; Gene expression.; Ankyrins.; Translocation, Genetic.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kakad, P. P. (2018). A Novel Role of the Ankyrin-Binding Motif of L1-Type CAM Neuroglian in Nuclear Import and Transcriptional Regulation of Myc. (Thesis). Florida Atlantic University. Retrieved from http://fau.digital.flvc.org/islandora/object/fau:40732

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kakad, Priyanka P. “A Novel Role of the Ankyrin-Binding Motif of L1-Type CAM Neuroglian in Nuclear Import and Transcriptional Regulation of Myc.” 2018. Thesis, Florida Atlantic University. Accessed February 27, 2021. http://fau.digital.flvc.org/islandora/object/fau:40732.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kakad, Priyanka P. “A Novel Role of the Ankyrin-Binding Motif of L1-Type CAM Neuroglian in Nuclear Import and Transcriptional Regulation of Myc.” 2018. Web. 27 Feb 2021.

Vancouver:

Kakad PP. A Novel Role of the Ankyrin-Binding Motif of L1-Type CAM Neuroglian in Nuclear Import and Transcriptional Regulation of Myc. [Internet] [Thesis]. Florida Atlantic University; 2018. [cited 2021 Feb 27]. Available from: http://fau.digital.flvc.org/islandora/object/fau:40732.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kakad PP. A Novel Role of the Ankyrin-Binding Motif of L1-Type CAM Neuroglian in Nuclear Import and Transcriptional Regulation of Myc. [Thesis]. Florida Atlantic University; 2018. Available from: http://fau.digital.flvc.org/islandora/object/fau:40732

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida Atlantic University

27. Kudumala, Sirisha. Functional roles of L1-Cam/Neuroglian in the nervous system of Drosophila Melanogaster.

Degree: 2014, Florida Atlantic University

URL: http://purl.flvc.org/fau/fd/FA00004131 ; (URL) http://purl.flvc.org/fau/fd/FA00004131

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Summary: Neuronal cell adhesion molecules of L1 family play a critical role in proper nervous system development. Various mutations on human L1-CAM that lead to… (more)

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Summary: Neuronal cell adhesion molecules of L1 family play a critical role in proper nervous system development. Various mutations on human L1-CAM that lead to severe neurodevelopmental disorders like retardation, spasticity etc. termed under L1 syndrome. The vertebrr their roles in axon pathfinding, neurite extension and cell migration, howeverate L1CAM and its homolog in Drosophila, neuroglian (nrg) have been well studied fo, much less is known about the mechanisms by which they fine tune synaptic connectivity to control the development and maintenance of synaptic connections within neuronal circuits. Here we characterized the essential role of nrg in regulating synaptic structure and function in vivo in a well characterized Drosophila central synapse model neuron, the Giant Fiber (GF) system. Previous studies from our lab revealed that the phosphorylation status of the tyrosine in the Ankyrin binding FIGQY motif in the intracellular domain of Nrg iscrucial for synapse formation of the GF to Tergo-Trochanteral Motor neuron (TTMn) synapse in the GF circuit. The present work provided us with novel insights into the role of Nrg-Ank interaction in regulating Nrg function during synapse formation and maintenance. By utilizing a sophisticated Pacman based genomic rescue strategy we have shown that dynamic regulation of the Neuroglian–Ankyrin interaction is required to coordinate transsynaptic development in the GF–TTMn synapse. In contrast, the strength of Ankyrin binding directly controls the balance between synapse formation and maintenance at the NMJ. Human L1 pathological mutations affect different biological processes distinctively and thus their proper characterization in vivo is essential to understand L1CAM function. By utilizing nrg14;P[nrg180ΔFIGQY] mutants that have exclusive synaptic defects and the previously characterized nrg849 allele that affected both GF guidance and synaptic function, we were able to analyze pathological L1CAM missense mutations with respect to their effects on guidance and synapse formation in vivo. We found that the human pathological H210Q, R184Q and Y1070C, but not the E309K and L120V L1CAM mutations affect outside-in signaling via the FIGQY Ankyrin binding domain which is required for synapse formation and not for axon guidance while L1CAM homophilic binding and signaling via the ERM motif is essential for axon guidance in Drosophila.

2014

Degree granted: Dissertation (Ph.D.) – Florida Atlantic University, 2014.

Collection: FAU

Advisors/Committee Members: Godenschwege, Tanja A. (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Science, Department of Biological Sciences.

Subjects/Keywords: Cell adhesion molecules; Cellular signal transduction; Cognitive neuroscience; Cognitive neuroscience; Drosophila melanogaster; Molecular neurobiology

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❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kudumala, S. (2014). Functional roles of L1-Cam/Neuroglian in the nervous system of Drosophila Melanogaster. (Thesis). Florida Atlantic University. Retrieved from http://purl.flvc.org/fau/fd/FA00004131 ; (URL) http://purl.flvc.org/fau/fd/FA00004131

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kudumala, Sirisha. “Functional roles of L1-Cam/Neuroglian in the nervous system of Drosophila Melanogaster.” 2014. Thesis, Florida Atlantic University. Accessed February 27, 2021. http://purl.flvc.org/fau/fd/FA00004131 ; (URL) http://purl.flvc.org/fau/fd/FA00004131.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kudumala, Sirisha. “Functional roles of L1-Cam/Neuroglian in the nervous system of Drosophila Melanogaster.” 2014. Web. 27 Feb 2021.

Vancouver:

Kudumala S. Functional roles of L1-Cam/Neuroglian in the nervous system of Drosophila Melanogaster. [Internet] [Thesis]. Florida Atlantic University; 2014. [cited 2021 Feb 27]. Available from: http://purl.flvc.org/fau/fd/FA00004131 ; (URL) http://purl.flvc.org/fau/fd/FA00004131.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kudumala S. Functional roles of L1-Cam/Neuroglian in the nervous system of Drosophila Melanogaster. [Thesis]. Florida Atlantic University; 2014. Available from: http://purl.flvc.org/fau/fd/FA00004131 ; (URL) http://purl.flvc.org/fau/fd/FA00004131

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

28. Bruce, Freyja Mairi. Determining the roles of DSCAM and SDK proteins in vertebrate visual system development.

Degree: School of Medical Sciences., 2011, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=185643 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=185643&custom_att_2=simple_viewer

Subjects/Keywords: Axons; Cell Adhesion Molecules.; Visual Pathways

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bruce, F. M. (2011). Determining the roles of DSCAM and SDK proteins in vertebrate visual system development. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=185643 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=185643&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Bruce, Freyja Mairi. “Determining the roles of DSCAM and SDK proteins in vertebrate visual system development.” 2011. Doctoral Dissertation, University of Aberdeen. Accessed February 27, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=185643 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=185643&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Bruce, Freyja Mairi. “Determining the roles of DSCAM and SDK proteins in vertebrate visual system development.” 2011. Web. 27 Feb 2021.

Vancouver:

Bruce FM. Determining the roles of DSCAM and SDK proteins in vertebrate visual system development. [Internet] [Doctoral dissertation]. University of Aberdeen; 2011. [cited 2021 Feb 27]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=185643 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=185643&custom_att_2=simple_viewer.

Council of Science Editors:

Bruce FM. Determining the roles of DSCAM and SDK proteins in vertebrate visual system development. [Doctoral Dissertation]. University of Aberdeen; 2011. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=185643 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=185643&custom_att_2=simple_viewer

Hong Kong University of Science and Technology

29. He, Yunyun LIFS. Biochemical, structural and functional characterization of usher syndrome I protein complexes and intermicrovillar adhesion complexes.

Degree: 2019, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-101512 ; https://doi.org/10.14711/thesis-991012753260903412 ; http://repository.ust.hk/ir/bitstream/1783.1-101512/1/th_redirect.html

► Brush border microvilli are actin-based protrusions lining the apical surface of epithelial cells in intestines and proximal tubules of kidneys. Similar with the relatively well-characterized… (more)

▼ Brush border microvilli are actin-based protrusions lining the apical surface of epithelial cells in intestines and proximal tubules of kidneys. Similar with the relatively well-characterized stereocilia in cochlea, brush border microvilli also form bundle-like protrusions and use cadherin-based tip-links to connect adjacent protrusions. For the stereocilia, the cytoplasmic face of the tip-link is stabilized and regulated by a protein complex composed of USH1C (aka Harmonin or AIE-75), USH1G and MYO7A. However, the mechanistic basis of tip-link complex organization in microvilli is poorly understood when compared with the stereocilia. In my thesis study, I systematically characterize the following pairs of interactions: CDHR2 and USH1C, USH1C and MYO7B, USH1C and ANKS4B, ANKS4B and MYO7B. We show that USH1C, ANKS4B, and MYO7B form a stable tripartite complex via these identified multivalent interactions for anchoring microvilli tip-link cadherins. Despite having only USH1C in common, the microvilli and the stereocilia tip-link complexes are formed via strikingly similar interaction modes. By using X-ray crystallography, we resolved 3 complex structures: USH1C NPDZ1/ANKS4B SAM-PBM, ANKS4B CEN/MYO7B NMFS and USH1C PDZ3/MYO7B CMF. The first two structures revealed similar binding modes with their counterparts in stereocilia. The USH1C PDZ3/MYO7B CMF complex structure reveal a novel binding mode both for MyTH4-FERM tandems and for PDZ domains. I further revealed MYO7A CMF also interacts USH1C PDZ3 with similar binding mode. Using purified entire MYO7B tail (M7BNC), full-length ANKS4B and USH1C, I reconstitute the tripartite complex M7BNC/USH1C/ANKS4B, and found that they can form highly concentrated condensates via multivalent interaction mediated liquid-liquid phase separation (LLPS). In heterologous cells, both MYO7A/USH1C/ANKS4B and MYO7B/USH1C/USH1G form condensed droplet via LLPS. Usher syndrome disease mutations can affect the multivalent interactions and reduce the LLPS capability of both MYO7B/USH1C/USH1G and MYO7A/USH1C/ANKS4B. We propose that the upper tip-link densities of stereocilia are formed by MYO7A/USH1C/ANKS4B through LLPS.

Subjects/Keywords: Epithelial cells ; Genetics ; Metabolism ; Hair cells ; Regeneration ; Usher's syndrome ; Cell adhesion molecules ; Labyrinth (Ear)

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

He, Y. L. (2019). Biochemical, structural and functional characterization of usher syndrome I protein complexes and intermicrovillar adhesion complexes. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-101512 ; https://doi.org/10.14711/thesis-991012753260903412 ; http://repository.ust.hk/ir/bitstream/1783.1-101512/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

He, Yunyun LIFS. “Biochemical, structural and functional characterization of usher syndrome I protein complexes and intermicrovillar adhesion complexes.” 2019. Thesis, Hong Kong University of Science and Technology. Accessed February 27, 2021. http://repository.ust.hk/ir/Record/1783.1-101512 ; https://doi.org/10.14711/thesis-991012753260903412 ; http://repository.ust.hk/ir/bitstream/1783.1-101512/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

He, Yunyun LIFS. “Biochemical, structural and functional characterization of usher syndrome I protein complexes and intermicrovillar adhesion complexes.” 2019. Web. 27 Feb 2021.

Vancouver:

He YL. Biochemical, structural and functional characterization of usher syndrome I protein complexes and intermicrovillar adhesion complexes. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2019. [cited 2021 Feb 27]. Available from: http://repository.ust.hk/ir/Record/1783.1-101512 ; https://doi.org/10.14711/thesis-991012753260903412 ; http://repository.ust.hk/ir/bitstream/1783.1-101512/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

He YL. Biochemical, structural and functional characterization of usher syndrome I protein complexes and intermicrovillar adhesion complexes. [Thesis]. Hong Kong University of Science and Technology; 2019. Available from: http://repository.ust.hk/ir/Record/1783.1-101512 ; https://doi.org/10.14711/thesis-991012753260903412 ; http://repository.ust.hk/ir/bitstream/1783.1-101512/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

30. Fraser, Stuart Tallis. Lectin - carbohydrate interactions in lympho-haemopoiesis: a study of L-selectin, ligands of L-selectin and CD24 inthe rat.

Degree: 1998, University of Hong Kong

URL: http://hdl.handle.net/10722/34826

Subjects/Keywords: Rats.; Cell adhesion molecules.; Blood proteins.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fraser, S. T. (1998). Lectin - carbohydrate interactions in lympho-haemopoiesis: a study of L-selectin, ligands of L-selectin and CD24 inthe rat. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/34826

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fraser, Stuart Tallis. “Lectin - carbohydrate interactions in lympho-haemopoiesis: a study of L-selectin, ligands of L-selectin and CD24 inthe rat.” 1998. Thesis, University of Hong Kong. Accessed February 27, 2021. http://hdl.handle.net/10722/34826.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fraser, Stuart Tallis. “Lectin - carbohydrate interactions in lympho-haemopoiesis: a study of L-selectin, ligands of L-selectin and CD24 inthe rat.” 1998. Web. 27 Feb 2021.

Vancouver:

Fraser ST. Lectin - carbohydrate interactions in lympho-haemopoiesis: a study of L-selectin, ligands of L-selectin and CD24 inthe rat. [Internet] [Thesis]. University of Hong Kong; 1998. [cited 2021 Feb 27]. Available from: http://hdl.handle.net/10722/34826.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fraser ST. Lectin - carbohydrate interactions in lympho-haemopoiesis: a study of L-selectin, ligands of L-selectin and CD24 inthe rat. [Thesis]. University of Hong Kong; 1998. Available from: http://hdl.handle.net/10722/34826

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations