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You searched for subject:(Cell Line Transformed). Showing records 1 – 3 of 3 total matches.

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1. Gaston, Isabelle. Mechanisms of bcr-abl-mediated oncogenesis.

Degree: PhD, 1999, Oregon Health Sciences University

Subjects/Keywords: Cytoskeleton  – genetics; Fusion Proteins, bcr-abl; Oncogene Proteins v-abl; Cell Line, Transformed

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Gaston, I. (1999). Mechanisms of bcr-abl-mediated oncogenesis. (Doctoral Dissertation). Oregon Health Sciences University. Retrieved from doi:10.6083/M4BC3WVT ; http://digitalcommons.ohsu.edu/etd/3342

Chicago Manual of Style (16th Edition):

Gaston, Isabelle. “Mechanisms of bcr-abl-mediated oncogenesis.” 1999. Doctoral Dissertation, Oregon Health Sciences University. Accessed March 07, 2021. doi:10.6083/M4BC3WVT ; http://digitalcommons.ohsu.edu/etd/3342.

MLA Handbook (7th Edition):

Gaston, Isabelle. “Mechanisms of bcr-abl-mediated oncogenesis.” 1999. Web. 07 Mar 2021.

Vancouver:

Gaston I. Mechanisms of bcr-abl-mediated oncogenesis. [Internet] [Doctoral dissertation]. Oregon Health Sciences University; 1999. [cited 2021 Mar 07]. Available from: doi:10.6083/M4BC3WVT ; http://digitalcommons.ohsu.edu/etd/3342.

Council of Science Editors:

Gaston I. Mechanisms of bcr-abl-mediated oncogenesis. [Doctoral Dissertation]. Oregon Health Sciences University; 1999. Available from: doi:10.6083/M4BC3WVT ; http://digitalcommons.ohsu.edu/etd/3342

2. 山本, 梓司. Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果.

Degree: 博士(医学), 2018, Saitama Medical University / 埼玉医科大学

Multiple sclerosis is a neuroinflammatory demyelinating and neurodegenerative disease of the central nervous system characterized by recurrent and progressive demyelination/remyelination cycles, neuroinflammation, oligodendrocyte loss, demyelination, and axonal degeneration. Cyclic phosphatidic acid (cPA) is a natural phospholipid mediator with a unique cyclic phosphate ring structure at the sn-2 and sn-3 positions of the glycerol backbone. We reported earlier that cPA elicits a neurotrophin-like action and protects hippocampal neurons from ischemia-induced delayed neuronal death. We designed, chemically synthesized, and metabolically stabilized derivatives of cPA: 2-carba-cPA (2ccPA), a synthesized compound in which one of the phosphate oxygen molecules is replaced with a methylene group at the sn-2 position. In the present study, we investigated whether 2ccPA exerts protective effects in oligodendrocytes and suppresses pathology in the two most common mouse models of multiple sclerosis.

To evaluate whether 2ccPA has potential beneficial effects on the pathology of multiple sclerosis, we investigated the effects of 2ccPA on oligodendrocyte cell death in vitro and administrated 2ccPA to mouse models of experimental autoimmune encephalomyelitis (EAE) and cuprizone-induced demyelination.

We demonstrated that 2ccPA suppressed the CoCl

-induced increase in the Bax/Bcl-2 protein expression ratio and phosphorylation levels of p38MAPK and JNK protein. 2ccPA treatment reduced cuprizone-induced demyelination, microglial activation, NLRP3 inflammasome, and motor dysfunction. Furthermore, 2ccPA treatment reduced autoreactive T cells and macrophages, spinal cord injury, and pathological scores in EAE, the autoimmune multiple sclerosis mouse model.

We demonstrated that 2ccPA protected oligodendrocytes via suppression of the mitochondrial apoptosis pathway. Also, we found beneficial effects of 2ccPA in the multiperiod of cuprizone-induced demyelination and the pathology of EAE. These data indicate that 2ccPA may be a promising compound for the development of new drugs to treat demyelinating disease and ameliorate the symptoms of multiple sclerosis.

平成29年度

Subjects/Keywords: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Differentiation; Cell Line, Transformed; Cuprizone; Demyelinating Diseases; Disease Models, Animal; Female; Gene Expression Regulation; Humans; MAP Kinase Signaling System; Male; Mice; Mice, Inbred C57BL; Monoamine Oxidase Inhibitors; Myelin Sheath; NLR Family, Pyrin Domain-Containing 3 Protein; Phosphatidic Acids; Proto-Oncogene Proteins c-bcl-2; p38 Mitogen-Activated Protein Kinases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

山本, . (2018). Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果. (Thesis). Saitama Medical University / 埼玉医科大学. Retrieved from http://id.nii.ac.jp/1386/00000615/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

山本, 梓司. “Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果.” 2018. Thesis, Saitama Medical University / 埼玉医科大学. Accessed March 07, 2021. http://id.nii.ac.jp/1386/00000615/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

山本, 梓司. “Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果.” 2018. Web. 07 Mar 2021.

Vancouver:

山本 . Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果. [Internet] [Thesis]. Saitama Medical University / 埼玉医科大学; 2018. [cited 2021 Mar 07]. Available from: http://id.nii.ac.jp/1386/00000615/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

山本 . Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease. : 脱髄性疾患における環状ホスファチジン酸誘導体の脱髄抑制及び治療効果. [Thesis]. Saitama Medical University / 埼玉医科大学; 2018. Available from: http://id.nii.ac.jp/1386/00000615/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Florida

3. Aslanian, Ara M., 1971-. Multiple nutrient adaptive mechanisms affect asparaginase resistance in MOLT-4 human leukemia cells.

Degree: 2000, University of Florida

Subjects/Keywords: Amino acids; Apoptosis; Cell growth; Cell lines; Complementary DNA; Cultured cells; Lymphocytes; Messenger RNA; Phosphorylation; Starvation; Asparaginase ( mesh ); Aspartate-Ammonia Ligase ( mesh ); Cell Line, Transformed ( mesh ); Department of Biochemistry and Molecular Biology thesis Ph.D ( mesh ); Drug Resistance, Neoplasm ( mesh ); Gene Expression Regulation ( mesh ); Leukemia, Lymphocytic, Acute  – drug therapy ( mesh ); Research ( mesh ); Transcription, Genetic ( mesh )

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Aslanian, Ara M., 1. (2000). Multiple nutrient adaptive mechanisms affect asparaginase resistance in MOLT-4 human leukemia cells. (Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/AA00038399

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Aslanian, Ara M., 1971-. “Multiple nutrient adaptive mechanisms affect asparaginase resistance in MOLT-4 human leukemia cells.” 2000. Thesis, University of Florida. Accessed March 07, 2021. https://ufdc.ufl.edu/AA00038399.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Aslanian, Ara M., 1971-. “Multiple nutrient adaptive mechanisms affect asparaginase resistance in MOLT-4 human leukemia cells.” 2000. Web. 07 Mar 2021.

Vancouver:

Aslanian, Ara M. 1. Multiple nutrient adaptive mechanisms affect asparaginase resistance in MOLT-4 human leukemia cells. [Internet] [Thesis]. University of Florida; 2000. [cited 2021 Mar 07]. Available from: https://ufdc.ufl.edu/AA00038399.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Aslanian, Ara M. 1. Multiple nutrient adaptive mechanisms affect asparaginase resistance in MOLT-4 human leukemia cells. [Thesis]. University of Florida; 2000. Available from: https://ufdc.ufl.edu/AA00038399

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.