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University of Guelph
1.
Ingrao, Joelle.
The Pharmacokinetics and Clinical Efficacy of Oral Carprofen in the Laboratory Mouse.
Degree: Doctor of Veterinary Science, Department of Pathobiology, 2014, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8506 
► Provision of analgesia to laboratory mice can be challenging, and administration of analgesics via the water bottle is attractive in that it diminishes the time,…
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▼ Provision of analgesia to laboratory mice can be challenging, and administration of analgesics via the water bottle is attractive in that it diminishes the time, training, skill, animal stress, and costs associated with other methods. The current study aimed to determine whether
carprofen could be administered to mice via the drinking water by assessing stability, palatability, and clinical efficacy following ovariectomy. We demonstrated that both injectable meloxicam and
carprofen are stable for 7 d in ambient light at room temperature, in dark at room temperature, and in dark at 4 °C.
Carprofen is palatable to mice when administered via the drinking water, whereas meloxicam-medicated water is non-palatable. Mice drink an average of 18.4 mL of
carprofen-medicated water / 100 g body weight / 24 h, and drink more in the dark phase compared to the light. Following a single oral gavage of 10 mg/kg
carprofen, peak plasma concentration (20.3 +/- 2.4 μg/mL) occurs at 2 h post-administration. With access to a
carprofen-medicated water bottle (10 mg/kg, 0.067 mg/mL), a comparable peak plasma concentration (17.0 +/- 2.9 μg/ml) is achieved following 12 to 24 h exposure. In order to assess clinical efficacy, mice received 10 or 20 mg/kg
carprofen subcutaneously (immediately postoperative) or gained access to a
carprofen-medicated water bottle for 24 h prior to ovariectomy. No significant behavioural changes were detected between treatment groups postoperatively. Following ovariectomy, pain was detected up to 1 h postoperatively, using facial grimacing as an indicator of pain. In comparison to control mice that did not undergo anesthesia or surgery, grimacing was reduced in duration in mice receiving 10 or 20 mg/kg
carprofen subcutaneously or orally. However, no overall statistically significant difference could be detected between treatment groups using the Mouse Grimace Scale. Administration of 20 mg/kg
carprofen subcutaneously or orally resulted in no significant difference in behavioural changes or facial grimacing compared to saline administration, which may be in part due to insufficient dose. The current study emphasizes the need for further evaluation of the clinical efficacy of nonsteroidal anti-inflammatory doses in mice prior to administration. Administration of
carprofen via the water may be a feasible and efficacious method to administer analgesics to laboratory mice; however, further studies are required to determine optimal doses to achieve sufficient analgesia, particularly across a wide range of painful procedures.
Advisors/Committee Members: Foster, Robert (advisor).
Subjects/Keywords: carprofen; meloxicam; analgesia; mouse grimace scale; behaviour
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APA (6th Edition):
Ingrao, J. (2014). The Pharmacokinetics and Clinical Efficacy of Oral Carprofen in the Laboratory Mouse. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8506
Chicago Manual of Style (16th Edition):
Ingrao, Joelle. “The Pharmacokinetics and Clinical Efficacy of Oral Carprofen in the Laboratory Mouse.” 2014. Doctoral Dissertation, University of Guelph. Accessed January 22, 2021.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8506.
MLA Handbook (7th Edition):
Ingrao, Joelle. “The Pharmacokinetics and Clinical Efficacy of Oral Carprofen in the Laboratory Mouse.” 2014. Web. 22 Jan 2021.
Vancouver:
Ingrao J. The Pharmacokinetics and Clinical Efficacy of Oral Carprofen in the Laboratory Mouse. [Internet] [Doctoral dissertation]. University of Guelph; 2014. [cited 2021 Jan 22].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8506.
Council of Science Editors:
Ingrao J. The Pharmacokinetics and Clinical Efficacy of Oral Carprofen in the Laboratory Mouse. [Doctoral Dissertation]. University of Guelph; 2014. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8506
Universiteit Utrecht
2.
Hoeven, L.M.A. van der.
Comparison of Robenacoxib and carprofen in palliative management of cancer pain.
Degree: 2014, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/297059
► When dogs with cancer are no longer (or not at all) treated for their illness, a palliative treatment should be given to increase the wellbeing…
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▼ When dogs with cancer are no longer (or not at all) treated for their illness, a palliative treatment should be given to increase the wellbeing of the dog. Dogs express pain in many different ways, sometimes by very subtle changes in behaviour. A brochure was created to inform owners about dogs that suffer from pain due to cancer and how to recognize this pain.
A blinded cross-over study was performed on 6 dogs with untreated tumors comparing Robenacoxib and carporal as a palliative therapy. These two NSAIDs were compared using three forms (scoring pain, quality of life and adverse events), filled in weekly by the owners of the dogs. During 4 weeks every dog received either
carprofen or Robenacoxib, they then had a wash-out period of one day without pain medication. Subsequently the other medication (either Robenacoxib or
carprofen) was given during the next 4 weeks.
When looking at the interim results, using a paired samples t-test and an independent samples t-test no significant differences between the two medications were found. Further research by examining more dogs is necessary to obtain more data. It is important to see whether or not a significant difference could be acquired between the medications in the future.
Advisors/Committee Members: Nimwegen, S.A. van.
Subjects/Keywords: dogs; palliative treatment; cancer; Robenacoxib; carprofen; pain; NSAID
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APA (6th Edition):
Hoeven, L. M. A. v. d. (2014). Comparison of Robenacoxib and carprofen in palliative management of cancer pain. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/297059
Chicago Manual of Style (16th Edition):
Hoeven, L M A van der. “Comparison of Robenacoxib and carprofen in palliative management of cancer pain.” 2014. Masters Thesis, Universiteit Utrecht. Accessed January 22, 2021.
http://dspace.library.uu.nl:8080/handle/1874/297059.
MLA Handbook (7th Edition):
Hoeven, L M A van der. “Comparison of Robenacoxib and carprofen in palliative management of cancer pain.” 2014. Web. 22 Jan 2021.
Vancouver:
Hoeven LMAvd. Comparison of Robenacoxib and carprofen in palliative management of cancer pain. [Internet] [Masters thesis]. Universiteit Utrecht; 2014. [cited 2021 Jan 22].
Available from: http://dspace.library.uu.nl:8080/handle/1874/297059.
Council of Science Editors:
Hoeven LMAvd. Comparison of Robenacoxib and carprofen in palliative management of cancer pain. [Masters Thesis]. Universiteit Utrecht; 2014. Available from: http://dspace.library.uu.nl:8080/handle/1874/297059
Universiteit Utrecht
3.
Spierenburg, J.E.
Comparison of robenacoxib and carprofen in the palliative management of cancer pain.
Degree: 2013, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/287210
► Robenacoxib is a nonsteroidal anti-inflammatory drug and a selective cyclooxygenase (COX) -2 inhibitor, registered for treatment of osteoarthritis and post-operative pain in dogs. In a…
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▼ Robenacoxib is a nonsteroidal anti-inflammatory drug and a selective cyclooxygenase (COX) -2 inhibitor, registered for treatment of osteoarthritis and post-operative pain in dogs. In a randomized cross over investigator-blinded trial with client-owned dogs diagnosed with a form of cancer, we compare treatment with robenacoxib versus
carprofen. Adverse effects (AEs), pain and Quality of Life (QoL) are assessed to determine which drug is the better choice in palliative management of the canine cancer patient. In the pain study, dogs were treated 28 days with one NSAID, had a wash out period of 1 day and were treated 28 days with the other NSAID. Physical examination and blood analysis were performed during a clinic visit every two weeks and every week forms assessing AEs, pain and QoL were filled out by the owner.
This research project report discusses results of the first four patients participating in this pain study. Results in this paper are blinded, because of continuation of the study.
The first patient showed no differences between treatments and only mild AEs and changes in scores, which were most likely caused by the effects of radiation therapy. The second dog survived 6 weeks and showed a difference in the two periods of the pain study, which may have been an idiosyncratic reaction of the dog to the NSAID secondly used. The third dog survived 3 weeks, thus was only treated with one NSAID; AEs and poor scores were most likely caused by progression of the tumour. The fourth dog showed no differences between treatments; AEs and changes in scores were most likely related to other causes than treatment.
Recruitment of patients and use of the forms are discussed and recommendations are given for the continuation of the pain study.
Advisors/Committee Members: Kirpensteijn, Prof. Dr. J.K..
Subjects/Keywords: robenacoxib; carprofen; NSAIDs; cancer; pain; pain management; palliative care; dogs; tumour
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APA (6th Edition):
Spierenburg, J. E. (2013). Comparison of robenacoxib and carprofen in the palliative management of cancer pain. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/287210
Chicago Manual of Style (16th Edition):
Spierenburg, J E. “Comparison of robenacoxib and carprofen in the palliative management of cancer pain.” 2013. Masters Thesis, Universiteit Utrecht. Accessed January 22, 2021.
http://dspace.library.uu.nl:8080/handle/1874/287210.
MLA Handbook (7th Edition):
Spierenburg, J E. “Comparison of robenacoxib and carprofen in the palliative management of cancer pain.” 2013. Web. 22 Jan 2021.
Vancouver:
Spierenburg JE. Comparison of robenacoxib and carprofen in the palliative management of cancer pain. [Internet] [Masters thesis]. Universiteit Utrecht; 2013. [cited 2021 Jan 22].
Available from: http://dspace.library.uu.nl:8080/handle/1874/287210.
Council of Science Editors:
Spierenburg JE. Comparison of robenacoxib and carprofen in the palliative management of cancer pain. [Masters Thesis]. Universiteit Utrecht; 2013. Available from: http://dspace.library.uu.nl:8080/handle/1874/287210
4.
Burg, M.J. van der.
Development of an adverse events questionnaire for the study of long-term treatment with NSAIDs in canine cancer patients.
Degree: 2013, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/281044
► In this paper, we discuss the development of an adverse events (AEs) questionnaire for the registration and documentation of adverse events (AEs) in a clinical…
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▼ In this paper, we discuss the development of an adverse events (AEs) questionnaire for the registration and documentation of adverse events (AEs) in a clinical trial with nonsteroidal anti-inflammatory drugs (NSAIDs) for the treatment of pain in canine cancer patients. The aim of the research project is to assess the usefulness of robenacoxib in comparison to
carprofen in the palliative treatment of canine cancer patients. The assessment of the treatment efficacy is done by scoring quality of life (QoL), pain and AEs. In literature, QoL scoring systems en pain scoring systems can be easily found (Lynch, 2010) (Iliopoulou, 2013) (Lavan, 2013). But in most clinical trials, AEs are recorded spontaneously or by interviewing owners (Edamura, 2012) (Vial, 2012) (Flor, 2013). We developed an AE questionnaire owners can fill out at home every week during the treatment period. The research question of this thesis is whether we succeeded in developing an AE questionnaire for the clinical trial with NSAIDs. During the development of the AE questionnaire another research question emerged. Namely, if the AE questionnaire might also be useful for owners with canine cancer patients undergoing chemotherapy at the Clinic of Companion Animals at the University of Utrecht.
In order to create the AE questionnaire, a selection of expected AEs in treatment with NSAIDs was made. This selection is based upon the mechanisms of action of NSAIDs and the known AEs reported by the European Medicines Agency (European Medicines Agency, 2011). We adapted the VCOG CTCAE v1.1, a grading system for AEs observed during chemotherapy in cats and dogs (Veterinary Cooperative Oncology Group, 2011). After translation and a first review, the developed questionnaire was tested twice. The first time its adequacy was tested in a group of canine patients without AEs. The second time its adequacy was tested in a group of canine cancer patients treated with chemotherapy. Based upon the first test, the final version of the AE was formed. Finally, owners of the second test group were asked for feedback on the AE questionnaire. In both tests, we find that owners think that the AE questionnaire we developed is clear and easy to fill out. The results of the survey reported that owners do not think that filling out the AE questionnaire is time consuming. But only 50% (4/8) of the owners think the AE questionnaire has added value.
In this study, we find that the AE questionnaire is adequate for the use in the research project with NSAIDs. However, we believe that the AE questionnaire should be adapted before it can be used in a clinical setting with canine cancer patients undergoing chemotherapy.
Advisors/Committee Members: Kirpensteijn, Jolle.
Subjects/Keywords: Diergeneeskunde; canine cancer, NSAIDs, Onsior, Carprofen
…carprofen and robenacoxib and their
effect on several organ systems.
2.2.1 Pharmacokinetics
NSAIDs… …Hence carprofen and robenacoxib are well-absorbed after oral administration. However… …are limited (KuKanich, 2012). Both
carprofen and robenacoxib have a relatively… …is a secondary route of elimination.
Conjugate products of carprofen are mainly excreted… …carprofen after oral administration is approximately 9 hours. The analgetic effect
of every dosage…
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APA (6th Edition):
Burg, M. J. v. d. (2013). Development of an adverse events questionnaire for the study of long-term treatment with NSAIDs in canine cancer patients. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/281044
Chicago Manual of Style (16th Edition):
Burg, M J van der. “Development of an adverse events questionnaire for the study of long-term treatment with NSAIDs in canine cancer patients.” 2013. Masters Thesis, Universiteit Utrecht. Accessed January 22, 2021.
http://dspace.library.uu.nl:8080/handle/1874/281044.
MLA Handbook (7th Edition):
Burg, M J van der. “Development of an adverse events questionnaire for the study of long-term treatment with NSAIDs in canine cancer patients.” 2013. Web. 22 Jan 2021.
Vancouver:
Burg MJvd. Development of an adverse events questionnaire for the study of long-term treatment with NSAIDs in canine cancer patients. [Internet] [Masters thesis]. Universiteit Utrecht; 2013. [cited 2021 Jan 22].
Available from: http://dspace.library.uu.nl:8080/handle/1874/281044.
Council of Science Editors:
Burg MJvd. Development of an adverse events questionnaire for the study of long-term treatment with NSAIDs in canine cancer patients. [Masters Thesis]. Universiteit Utrecht; 2013. Available from: http://dspace.library.uu.nl:8080/handle/1874/281044
Louisiana State University
5.
Snow, Lynne A.
Carprofen-induced oxidative stress in mitochondria of the colonic mucosa of the dog.
Degree: MS, Veterinary Medicine, 2010, Louisiana State University
URL: etd-04272010-221042
;
https://digitalcommons.lsu.edu/gradschool_theses/672
► Objectives 1) To measure conductance and permeability of canine colonic mucosa exposed to increasing concentrations of carprofen. 2) To compare conductance and permeability of…
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▼ Objectives 1) To measure conductance and permeability of canine colonic mucosa exposed to increasing concentrations of carprofen. 2) To compare conductance and permeability of canine colonic mucosa exposed to carprofen or 2,4-dinitrophenol (DNP) and tempol blockade. Design In vitro randomized block design Animal 20 mixed breed dogs Methods Conductance, mannitol flux, and histology were evaluated in colonic mucosa mounted in Ussing chambers. Mucosa was first exposed to increasing concentrations of carprofen. Mucosa was then exposed to either carprofen (200 μg/ml) or DNP (0.25mM) +/- tempol (1mM) pretreatment. Conductance over time, mannitol fluxes, and frequency of histologic categories were analyzed for treatment effects. Histopathology and electron microscopy were evaluated post experiment. Results Mean +/- SEM conductance*time for 400 μg/ml carprofen treated colon was significantly greater than control. Mean +/- SEM conductance*time for carprofen treated colon at 200, 100 and 40 μg/ml were not significantly different from control. Mean +/- SEM conductance*time for 400 μg/ml and 200 μg/ml carprofen treated colon were not significantly different. Period 3 mannitol flux was greater than period 1 for 400 μg/ml and 200 μg/ml carprofen treated colon but not significantly different for 100 μg/ml, 40 μg/ml, and control. Period 3 flux for 400 μg/ml and 200 μg/ml carprofen treated colon were not different but were greater than control. Mean +/- SEM conductance*time for carprofen or DNP treated colon were not significantly different from control regardless of blockade. Period 3 flux for carprofen and DNP treated colon were not different but were greater than control. Period 3 flux for carprofen treated colon with tempol pretreatment was not significantly different than control. Period 3 flux for DNP treated colon with tempol pretreatment was not different than without tempol but was greater than control. Cell sloughing and erosions were observed with high carprofen concentrations. Mitochondrial damage was seen with carprofen treatment compared to DNP treatment or control. Tempol pretreatment effect on mitochondrial morphology was inconsistent. Conclusion Carprofen exhibits concentration dependent toxicity to canine colonic mucosa. Carprofen and DNP induce similar mucosal damage evident by changes in electrical conductance, mannitol flux, and histopathology. Carprofen damages enterocyte mitochondria.
Subjects/Keywords: dinitrophenol; tempol; carprofen; oxidative stress; mitochondria; colon; DNP
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APA (6th Edition):
Snow, L. A. (2010). Carprofen-induced oxidative stress in mitochondria of the colonic mucosa of the dog. (Masters Thesis). Louisiana State University. Retrieved from etd-04272010-221042 ; https://digitalcommons.lsu.edu/gradschool_theses/672
Chicago Manual of Style (16th Edition):
Snow, Lynne A. “Carprofen-induced oxidative stress in mitochondria of the colonic mucosa of the dog.” 2010. Masters Thesis, Louisiana State University. Accessed January 22, 2021.
etd-04272010-221042 ; https://digitalcommons.lsu.edu/gradschool_theses/672.
MLA Handbook (7th Edition):
Snow, Lynne A. “Carprofen-induced oxidative stress in mitochondria of the colonic mucosa of the dog.” 2010. Web. 22 Jan 2021.
Vancouver:
Snow LA. Carprofen-induced oxidative stress in mitochondria of the colonic mucosa of the dog. [Internet] [Masters thesis]. Louisiana State University; 2010. [cited 2021 Jan 22].
Available from: etd-04272010-221042 ; https://digitalcommons.lsu.edu/gradschool_theses/672.
Council of Science Editors:
Snow LA. Carprofen-induced oxidative stress in mitochondria of the colonic mucosa of the dog. [Masters Thesis]. Louisiana State University; 2010. Available from: etd-04272010-221042 ; https://digitalcommons.lsu.edu/gradschool_theses/672
Technical University of Lisbon
6.
Godinho, Ricardo Freire.
Analgesia pós-cirúrgica em correcções de deslocamento de abomaso à esquerda.
Degree: 2011, Technical University of Lisbon
URL: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/3579
► Dissertação de Mestrado Integrado em Medicina Veterinária
A identificação da dor animal é um aspecto com cada vez maior importância na produção animal, assim como…
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▼ Dissertação de Mestrado Integrado em Medicina Veterinária
A identificação da dor animal é um aspecto com cada vez maior importância na produção animal, assim como o é minimizar os processos dolorosos ao longo de todos os procedimentos de produção. Quando não for possível eliminar esses estímulos dolorosos, deve ser dada prioridade à devida analgesia.
Um desses procedimentos dolorosos é a cirurgia, neste caso, a cirurgia correctiva de deslocamento de abomaso à esquerda. Como não é possível eliminar os estímulos dolorosos resultantes da cirurgia, o que nos resta é proceder à devida analgesia pós-cirúrgica. O objectivo deste trabalho foi perceber se a administração de carprofeno possui maior duração de analgesia do que a flunixina meglumina no maneio de dor pós-cirúrgico na correcção de Deslocamento de Abomaso à Esquerda (DAE). O carprofeno, tal como a flunixina meglumina, é um anti-inflamatório não esteróide, mas é menos utilizado na analgesia pós-cirúrgica devido ao seu custo, apesar de possuir um tempo de semi-vida superior ao da flunixina meglumina.
O estudo foi realizado em 26 vacas de raça Holstein Frísia submetidas a correcção cirúrgica de DAE, que foram divididas em dois grupos: Grupo F (14 animais submetidos à administração de flunixina meglumina) e o Grupo C (12 animais submetidos à administração de carprofeno). A analgesia pós-cirúrgica foi avaliada utilizando parâmetros produtivos (produção leiteira nos 8 dias após a cirurgia) e utilizando parâmetros fisiológicos (corpos cetónicos por mensuração de β-hidroxibutiratos sanguíneos no dia 1, 2 e 4).
Concluiu-se que não existem diferenças os entre fármacos na analgesia pós-cirúrgica na correcção de DAE, e que para obter resultados mais fidedignos mais estudo serão necessários no futuro.
ABSTRACT - Post-surgical analgesia adjustments left-side displacement of the abomasum -
The identification of animal pain is an aspect with growing importance in animal production, as well as minimize the painful processes across all production procedures. When it´s not possible the elimination of the painful stimuli, the analgesia must be prioritized.
One of this painful procedures is surgery, in this case, the corrective surgery of the left displaced abomasums (LDA). It is appropriate to perform postoperative analgesia since the elimination of painful stimuli resulting from surgery cannot be done. The objective of this work was to understand if the administration of carprofen has a longer duration of analgesia than the administration of flunixin meglumine in the management of postoperative pain in surgical correction of LDA. Carprofen, as flunixin meglumine, is an anti-inflammatory non esteriod, but it’s less is used, for postoperative analgesia, because of its cost, despite having a half-life greater than flunixin meglumine.
The study was conducted on 26 Holstein Friesian cows undergoing surgical correction of LDA, which were divided into two groups: Group F (submitted to the administration of flunixin meglumine) and Group C (submitted to the administration of…
Advisors/Committee Members: Gomes, Elsa Bastos Carriço Monteiro Grillo, Stilwell, George Thomas.
Subjects/Keywords: Analgesia pós-cirúrgica; Dor; Deslocamento de abomaso à esquerda; Carprofeno; Flunixina Meglumina; Post-surgical analgesia; Pain; Left-side displacement of the abomasum; Carprofen; Flunixin meglumine
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APA (6th Edition):
Godinho, R. F. (2011). Analgesia pós-cirúrgica em correcções de deslocamento de abomaso à esquerda. (Thesis). Technical University of Lisbon. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/3579
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Godinho, Ricardo Freire. “Analgesia pós-cirúrgica em correcções de deslocamento de abomaso à esquerda.” 2011. Thesis, Technical University of Lisbon. Accessed January 22, 2021.
http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/3579.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Godinho, Ricardo Freire. “Analgesia pós-cirúrgica em correcções de deslocamento de abomaso à esquerda.” 2011. Web. 22 Jan 2021.
Vancouver:
Godinho RF. Analgesia pós-cirúrgica em correcções de deslocamento de abomaso à esquerda. [Internet] [Thesis]. Technical University of Lisbon; 2011. [cited 2021 Jan 22].
Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/3579.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Godinho RF. Analgesia pós-cirúrgica em correcções de deslocamento de abomaso à esquerda. [Thesis]. Technical University of Lisbon; 2011. Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/3579
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Virginia Tech
7.
Reimer, Michele E.
The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs.
Degree: MS, Veterinary Medical Sciences, 1999, Virginia Tech
URL: http://hdl.handle.net/10919/33049
► Twenty-four healthy, mixed breed dogs were divided into four groups. Group I received a placebo PO BID, group II received an average 16.5 (range, 15.1-17.8)…
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▼ Twenty-four healthy, mixed breed dogs were divided into four groups. Group I received a placebo PO BID, group II received an average 16.5 (range, 15.1-17.8) mg/kg buffered aspirin PO BID, group III received an average 2.2 (range, 2.0-2.4) mg/kg
carprofen PO BID, and group IV received an average 12.8 (range, 11.7-13.8) mg/kg etodolac PO QD (with a placebo in the P.M.). All treatments continued for 28 consecutive days. Gastroduodenal endoscopy was performed on days – 9, 0, 5, 14 and 28. Multiple gastric biopsies were obtained endoscopically on day – 9 to determine each dog's Helicobacter spp. status.
Five areas, consisting of four regions in the stomach and one in the proximal duodenum, were evaluated endoscopically, and each was assigned a score from 1 to 11 based on qualitative assessment of submucosal hemorrhage, erosion, or ulceration. These scores for each region were then summed to give a total score for each endoscopic evaluation.
Erosions and submucosal hemorrhages were seen in all dogs receiving aspirin. Only minor gastric lesions were observed in the
carprofen, etodolac, and control groups. No adverse clinical signs were noted in any dog given any treatment during the course of the study. There was no predilection site for lesion development in any group. Median total score on days 0, 5, 14, and 28 were as follows: group I, 5.0, 5.0, 5.0, 5.0; group II, 5.0, 27.0, 26.0, 27.5; group III, 5.0, 5.0, 6.0, 5.0; group IV, 5.0, 7.0, 5.0, 5.0, respectively.
There was no significant difference between dogs receiving
carprofen, etodolac, or placebo. The administration of
carprofen, etodolac, or placebo to healthy dogs resulted in significantly less gastroduodenal lesion development than in dogs receiving buffered aspirin.
Thirty healthy, random source, dogs were evaluated to determine the prevalence of Helicobacter spp., and to compare the ‘Campylobacter-like organism’ test (CLOtest®) to histopathologic identification of Helicobacter spp. organisms. Gastric mucosal biopsies from each of four gastric regions (cardia, pyloric antrum, greater curvature, and angularis incisura) were obtained endoscopically for use in the CLOtest® and for histopathologic evaluation. Twenty-seven of 30 dogs (90%) were positive for spiral bacteria suspected to be Helicobacter spp. by histopathologic evaluation in at least one of the four gastric regions. Three dogs (10%) were negative for Helicobacter spp. in all gastric regions by histopathologic evaluation. The CLOtest® was found to have a sensitivity, specificity, and positive predictive value of 84%, 81%, and 92%, respectively, when compared to histopathologic evaluation. When only the angularis incisura was evaluated, the sensitivity, specificity, and positive predictive value increased to 92%, 94%, and 96%, respectively. The angularis incisura had the highest, whereas the pyloric antrum had the lowest, prevalence of positive test results when compared to dogs determined to be overall Helicobacter spp. positive (histopathologic positive in at least one gastric region). The…
Advisors/Committee Members: Johnston, Spencer A. (committeechair), Pfeiffer, Carl J. (committee member), Leib, Michael S. (committee member), Duncan, Robert B. Jr. (committee member).
Subjects/Keywords: Non-steroidal Anti-inflammatory drugs; Endoscopy; Gastric Ulceration; Carprofen; Helicobacter; Canine; Etodolac
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APA (6th Edition):
Reimer, M. E. (1999). The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs. (Masters Thesis). Virginia Tech. Retrieved from http://hdl.handle.net/10919/33049
Chicago Manual of Style (16th Edition):
Reimer, Michele E. “The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs.” 1999. Masters Thesis, Virginia Tech. Accessed January 22, 2021.
http://hdl.handle.net/10919/33049.
MLA Handbook (7th Edition):
Reimer, Michele E. “The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs.” 1999. Web. 22 Jan 2021.
Vancouver:
Reimer ME. The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs. [Internet] [Masters thesis]. Virginia Tech; 1999. [cited 2021 Jan 22].
Available from: http://hdl.handle.net/10919/33049.
Council of Science Editors:
Reimer ME. The Gastroduodenal Effects of Buffered Aspirin, Carprofen, And Etodolac in the Healthy Dog and Comparison of the CLOtest® to Histopathologic Evaluation in Identifying the Presence of Helicobacter Spp. in Healthy Dogs. [Masters Thesis]. Virginia Tech; 1999. Available from: http://hdl.handle.net/10919/33049
. 
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