subject:(Cardiovascular physiology)

Dalhousie University

1. Goreham, Joshua. THE MEASUREMENT OF TOE ARTERIAL BLOOD PRESSURE DURING REST, CYCLING, AND WALKING.

Degree: MS, School of Health & Human Performance, 2014, Dalhousie University

► The Portapres is thought to be a device that can provide accurate toe blood pressure measurements. The first aim of the study was to validate… (more)

Subjects/Keywords: Biomechanics; Cardiovascular Physiology

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APA (6^th Edition):

Goreham, J. (2014). THE MEASUREMENT OF TOE ARTERIAL BLOOD PRESSURE DURING REST, CYCLING, AND WALKING. (Masters Thesis). Dalhousie University. Retrieved from http://hdl.handle.net/10222/54047

Chicago Manual of Style (16^th Edition):

Goreham, Joshua. “THE MEASUREMENT OF TOE ARTERIAL BLOOD PRESSURE DURING REST, CYCLING, AND WALKING.” 2014. Masters Thesis, Dalhousie University. Accessed March 02, 2021. http://hdl.handle.net/10222/54047.

MLA Handbook (7^th Edition):

Goreham, Joshua. “THE MEASUREMENT OF TOE ARTERIAL BLOOD PRESSURE DURING REST, CYCLING, AND WALKING.” 2014. Web. 02 Mar 2021.

Vancouver:

Goreham J. THE MEASUREMENT OF TOE ARTERIAL BLOOD PRESSURE DURING REST, CYCLING, AND WALKING. [Internet] [Masters thesis]. Dalhousie University; 2014. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10222/54047.

Council of Science Editors:

Goreham J. THE MEASUREMENT OF TOE ARTERIAL BLOOD PRESSURE DURING REST, CYCLING, AND WALKING. [Masters Thesis]. Dalhousie University; 2014. Available from: http://hdl.handle.net/10222/54047

University of Manitoba

2. Ramjiawan, Angela. Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter.

Degree: Physiology, 2010, University of Manitoba

URL: http://hdl.handle.net/1993/4160

► PGC-1α regulates cardiac mitochondrial biogenesis and energy metabolic gene expression, thus transcriptional regulation of PGC-1α gene expression is of great importance in understanding metabolic gene… (more)

Subjects/Keywords: Cardiovascular Physiology; Molecular Pathophysiology

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APA (6^th Edition):

Ramjiawan, A. (2010). Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/4160

Chicago Manual of Style (16^th Edition):

Ramjiawan, Angela. “Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter.” 2010. Masters Thesis, University of Manitoba. Accessed March 02, 2021. http://hdl.handle.net/1993/4160.

MLA Handbook (7^th Edition):

Ramjiawan, Angela. “Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter.” 2010. Web. 02 Mar 2021.

Vancouver:

Ramjiawan A. Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter. [Internet] [Masters thesis]. University of Manitoba; 2010. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1993/4160.

Council of Science Editors:

Ramjiawan A. Transcriptional regulation of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) promoter. [Masters Thesis]. University of Manitoba; 2010. Available from: http://hdl.handle.net/1993/4160

3. Baburaj.T.P. Some aspects of the physiology of temperature induced stress in human volunteers with particular reference to cardiovascular system;.

Degree: Physiology, 2014, University of Calicut

URL: http://shodhganga.inflibnet.ac.in/handle/10603/30212

newline

References p.97-109,Appendix

Advisors/Committee Members: T.Ramakrishna.

Subjects/Keywords: Cardiovascular system; Physiology

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APA (6^th Edition):

Baburaj.T.P. (2014). Some aspects of the physiology of temperature induced stress in human volunteers with particular reference to cardiovascular system;. (Thesis). University of Calicut. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/30212

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Baburaj.T.P. “Some aspects of the physiology of temperature induced stress in human volunteers with particular reference to cardiovascular system;.” 2014. Thesis, University of Calicut. Accessed March 02, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/30212.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Baburaj.T.P. “Some aspects of the physiology of temperature induced stress in human volunteers with particular reference to cardiovascular system;.” 2014. Web. 02 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Baburaj.T.P. Some aspects of the physiology of temperature induced stress in human volunteers with particular reference to cardiovascular system;. [Internet] [Thesis]. University of Calicut; 2014. [cited 2021 Mar 02]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/30212.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Baburaj.T.P. Some aspects of the physiology of temperature induced stress in human volunteers with particular reference to cardiovascular system;. [Thesis]. University of Calicut; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/30212

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University

4. Otto, Delita. Exploring underlying mechanisms driving the onset of stress-induced insulin resistance.

Degree: MSc, Physiological Sciences, 2012, Stellenbosch University

URL: http://hdl.handle.net/10019.1/20125

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ENGLISH ABSTRACT: Physical and psychological stressors trigger activation of the hypothalamo-pituitary-adrenocortical (HPA) axis that leads to enhanced secretion of glucocorticoids e.g. cortisol. Moreover, chronic activation… (more)

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ENGLISH ABSTRACT: Physical and psychological stressors trigger activation of the hypothalamo-pituitary-adrenocortical (HPA) axis that leads to enhanced secretion of glucocorticoids e.g. cortisol. Moreover, chronic activation of this pathway may elevate oxidative stress that is linked to the onset of insulin resistance and cardiovascular diseases (CVD). Our laboratory previously found that oxidative stress increases flux through metabolic circuits such as the hexosamine biosynthetic pathway (HBP), in effect increasing its modification of target proteins post-transcriptionally with O-GlcNAc moeities. This in turn may alter protein function and contribute to the onset of myocardial insulin resistance and impaired contractile function. Since the underlying mechanisms linking chronic stress to cardiometabolic pathophysiology are poorly understood, we hypothesised that cortisol elicits myocardial oxidative stress, HBP activation, and decreased glucose uptake (due to attenuated glucose transport functionality) with detrimental outcomes, i.e. insulin resistance and apoptosis. To investigate this hypothesis we established an in vitro model using HL-1 cardiomyocytes, with which we evaluated the degree of O-GlcNAcylation and oxidative stress in response to a range of time-dose treatments with dexamethasone (synthetic glucocorticoid). Glucose transporter 4 (GLUT4) translocation to the sarcolemma was also assessed. In agreement with the literature, results suggest that GLUT4 translocation is significantly decreased subsequent to dexamethasone treatment. Although no significant differences were observed with regards to oxidative stress or O-GlcNAcylation, the data show that dexamethasone increased the latter with a maximal effect after two hours exposure to the 10-6 M dose. Although our results were not conclusive, the data suggest a potential novel link between dexamethasone exposure, HBP activation and decreased GLUT4 translocation. Based on our findings we propose that detrimental effects of chronic stress on the heart may be mediated by increased HBP flux. Given that glucocorticoid excess and GLUT4 dysregulation have been associated with insulin resistance (and related metabolic derangements and diseases), these results provide new targets for potential therapeutic agents.

AFRIKAANSE OPSOMMING: Fisiese sowel as psigologiese stressors veroorsaak die aktivering van die hipotalamiese-hipo seale-bynier (HHB) pad wat lei tot die verhoogde sekresie van glukokortikoïede soos kortisol. Kroniese aktivering van hierdie pad kan ook oksidatiewe stres verhoog wat weer tot insulienweerstandigheid en kardiovaskulêre siektes (KVS) kan lei. Navorsing uit ons laboratorium het voorheen bewys dat oksidatiewe stres 'n toename in vloei deur metaboliese paaie soos die heksoamine biosintetiese pad (HBP) kan veroorsaak deur die modi sering van teikenproteïene met O-GlcNAc motiewe. Dit kan weer proteïen funksie verander en bydra tot die ontstaan van miokardiale insulienweerstandigheid en verswakte kontraktiele funksie.…

Advisors/Committee Members: Essop, M. F., Stellenbosch University. Faculty of Science. Dept. of Physiological Sciences..

Subjects/Keywords: Physiology (Human and animal); Cardiovascular diseases; Apoptosis

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APA (6^th Edition):

Otto, D. (2012). Exploring underlying mechanisms driving the onset of stress-induced insulin resistance. (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/20125

Chicago Manual of Style (16^th Edition):

Otto, Delita. “Exploring underlying mechanisms driving the onset of stress-induced insulin resistance.” 2012. Masters Thesis, Stellenbosch University. Accessed March 02, 2021. http://hdl.handle.net/10019.1/20125.

MLA Handbook (7^th Edition):

Otto, Delita. “Exploring underlying mechanisms driving the onset of stress-induced insulin resistance.” 2012. Web. 02 Mar 2021.

Vancouver:

Otto D. Exploring underlying mechanisms driving the onset of stress-induced insulin resistance. [Internet] [Masters thesis]. Stellenbosch University; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10019.1/20125.

Council of Science Editors:

Otto D. Exploring underlying mechanisms driving the onset of stress-induced insulin resistance. [Masters Thesis]. Stellenbosch University; 2012. Available from: http://hdl.handle.net/10019.1/20125

McMaster University

5. Totosy de Zepetnek, Julia. Cardiovascular health and physical activity among individuals with spinal cord injury.

Degree: PhD, 2014, McMaster University

URL: http://hdl.handle.net/11375/16389

►

An increased prevalence and earlier onset of cardiovascular disease (CVD) occurs in persons with spinal cord injury (SCI); the higher risk may be explained by… (more)

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An increased prevalence and earlier onset of cardiovascular disease (CVD) occurs in persons with spinal cord injury (SCI); the higher risk may be explained by novel CVD risk factors of aerobic capacity and peripheral vascular structure and function. Physical inactivity likely contributes to the basis of increased CVD risk after SCI, however evidence on the effectiveness of exercise programs in attenuating CVD risk in SCI is insufficient. The present thesis evaluated novel CVD risk factors in a cohort of individuals with chronic SCI, and examined the effects of a single bout of exercise and exercise training on CVD risk. The first study demonstrated dramatic decreases in body composition, aerobic capacity, and sublesional endothelial function via flow-mediated dilation (FMD) in adults with chronic SCI vs. able-bodied (AB) controls. The second, third, and fourth studies assessed the role of shear rate (SR) patterns on FMD. Elevated retrograde SR had a detrimental effect on brachial and superficial-femoral-artery (SFA) FMD in both SCI and AB, but elevated anterograde SR had a favorable effect on SFA FMD in AB only. The fifth study demonstrated that sublesional vasculature does not respond to a 4-month combination aerobic and resistance-training program using the recently released physical activity guidelines for adults with SCI (PAG). The results of this thesis highlight the multilayered regulation of sublesional vasculature, and that it may respond differently to a single bout of exercise and exercise training when compared to an AB population. This information is crucial when designing strategies to combat impaired vascular structure and function after SCI. The results from this thesis also indicate the potential for the PAG to improve aspects of anthropometrics, body composition, and carotid vascular health in adults with SCI. Further investigations are necessary to delineate the effects of SCI itself, and of exercise, on CVD risk in this population.

Dissertation

Doctor of Science (PhD)

Advisors/Committee Members: MacDonald, Maureen, Kinesiology.

Subjects/Keywords: cardiovascular physiology; spinal cord injury; physical activity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Totosy de Zepetnek, J. (2014). Cardiovascular health and physical activity among individuals with spinal cord injury. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/16389

Chicago Manual of Style (16^th Edition):

Totosy de Zepetnek, Julia. “Cardiovascular health and physical activity among individuals with spinal cord injury.” 2014. Doctoral Dissertation, McMaster University. Accessed March 02, 2021. http://hdl.handle.net/11375/16389.

MLA Handbook (7^th Edition):

Totosy de Zepetnek, Julia. “Cardiovascular health and physical activity among individuals with spinal cord injury.” 2014. Web. 02 Mar 2021.

Vancouver:

Totosy de Zepetnek J. Cardiovascular health and physical activity among individuals with spinal cord injury. [Internet] [Doctoral dissertation]. McMaster University; 2014. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/11375/16389.

Council of Science Editors:

Totosy de Zepetnek J. Cardiovascular health and physical activity among individuals with spinal cord injury. [Doctoral Dissertation]. McMaster University; 2014. Available from: http://hdl.handle.net/11375/16389

University of Oxford

6. Isackson, Henrik Carl Anders. The effects of high fat diet feeding on cardiac function in the C57BL6/J mouse strain.

Degree: PhD, 2014, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:120f7b20-d324-4d35-8024-79b42200c08a ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665160

► It has been established that placing the C57BL6/J mouse on a high fat diet induces obesity and impaired glucose homeostasis, and produces a model that… (more)

▼ It has been established that placing the C57BL6/J mouse on a high fat diet induces obesity and impaired glucose homeostasis, and produces a model that is pathophysiologically relevant to the human condition of the metabolic syndrome. The cardiovascular changes in this model have been relatively poorly explored. I have focussed my work on understanding the effects of this diet on cardiac function using in vivo cardiac functional assessment in combination with in vitro analysis of intact single cardiomyocyte dynamics and Ca2+ handling, as well as demembranated left ventricle trabeculae for the study of myofilament function. High fat diet caused increased left ventricular end diastolic pressure after 30 weeks as assessed by in vivo pressure catheterisation. This change was associated with, increased passive tension in demembranated trabeculae at 30 w, increased collagen 3 expression on mRNA level and increased total tissue collagen from high fat diet after 40 weeks. Reversion to normal diet for 10 weeks had no discernible effect on whole organ function compared with animals continually fed with the high fat diet, despite body fat content and glucose homeostasis becoming normalised. Isolated cardiomyocytes exhibited increased relaxation rate after 40 weeks which was partly reversed by a return to normal diet. The increased cardiomyocyte relaxation rate occurred without changes to the intracellular Ca2+ transient, thus suggesting it may be caused by altered myofilament Ca2+ sensitivity. There was no established decreased myofilament Ca2+ sensitivity seen in demembranated trabeculae at week 40, even though trends were seen towards increased phosphorylation of serines 23/24 of cardiac troponin I, a modification known to induce Ca2+ desensitisation. It is concluded that high fat diet feeding in the C57BL6/J mouse is a mild but valid model for studying the effects on cardiac function of obesity and impaired glucose handling. It results in impaired diastolic function at the whole organ level after 30 weeks feeding. This effect is likely principally caused by extracellular deposition of collagen (which reduces compliance) rather than by changes at the cardiomyocyte level. This whole organ diastolic alteration appears to become established, not responding to dietary fat reduction. The increased relaxation rate of cardiomyocytes more likely originates from changes at the myofilament level as opposed to Ca2+ handling although this could not be statistically verified in this study. As high fat diet feeding was found to increase myocardial NADPH oxidase activity, myofilament function was also assessed in a mouse model of NADPH oxidase 2 over-expression. NADPH oxidase 2 over-expression was found to cause myofilament sensitisation to Ca2+ and increased actomyosin cross bridge cycling rate at maximum Ca2+ activation. This was associated with an increased total phosphorylation of cardiac troponin I independent of phosphorylation of serines 23/24. This finding may represent a new signalling pathway linking NADPH oxidase 2 activity to…

Subjects/Keywords: 618.3; Pathology; Diabetes; Cardiovascular disease; Physiology

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APA (6^th Edition):

Isackson, H. C. A. (2014). The effects of high fat diet feeding on cardiac function in the C57BL6/J mouse strain. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:120f7b20-d324-4d35-8024-79b42200c08a ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665160

Chicago Manual of Style (16^th Edition):

Isackson, Henrik Carl Anders. “The effects of high fat diet feeding on cardiac function in the C57BL6/J mouse strain.” 2014. Doctoral Dissertation, University of Oxford. Accessed March 02, 2021. http://ora.ox.ac.uk/objects/uuid:120f7b20-d324-4d35-8024-79b42200c08a ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665160.

MLA Handbook (7^th Edition):

Isackson, Henrik Carl Anders. “The effects of high fat diet feeding on cardiac function in the C57BL6/J mouse strain.” 2014. Web. 02 Mar 2021.

Vancouver:

Isackson HCA. The effects of high fat diet feeding on cardiac function in the C57BL6/J mouse strain. [Internet] [Doctoral dissertation]. University of Oxford; 2014. [cited 2021 Mar 02]. Available from: http://ora.ox.ac.uk/objects/uuid:120f7b20-d324-4d35-8024-79b42200c08a ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665160.

Council of Science Editors:

Isackson HCA. The effects of high fat diet feeding on cardiac function in the C57BL6/J mouse strain. [Doctoral Dissertation]. University of Oxford; 2014. Available from: http://ora.ox.ac.uk/objects/uuid:120f7b20-d324-4d35-8024-79b42200c08a ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665160

University of Oxford

7. Bull, Sacha Colette. Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis.

Degree: PhD, 2012, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588388

► The management of the asymptomatic patients with severe aortic stenosis (AS) is challenging; clinicians have to balance the risks of early surgery against the risk… (more)

▼ The management of the asymptomatic patients with severe aortic stenosis (AS) is challenging; clinicians have to balance the risks of early surgery against the risk that irreversible myocardial damage may occur with a conservative management strategy. It has become increasingly apparent that prognosis in asymptomatic AS depends not only on the degree of valvular stenosis, but also on the myocardial response to pressure overload and understanding the mechanisms of myocardial decompensation may help to guide management in the future. The degree of myocardial fibrosis, microvascular dysfunction, hypertrophy and left ventricular (LV) geometry may all play important roles. However, current guidelines for management of asymptomatic AS limit assessment of the myocardium to the measurement of ejection fraction with echocardiography. More advanced techniques may provide greater information that could be clinically useful. This thesis seeks to further our understanding of the mechanisms of the myocardial response to AS, using Cardiac Magnetic Resonance (CMR) in patients with moderate and severe AS. Myocardial perfusion in AS is examined in chapter 3. The results show that CMR first pass perfusion can be carried out safely and is well tolerated by AS patients. Microvascular dysfunction in these patients was associated with age, exercise time and markers of diastolic dysfunction. Myocardial strain is examined in chapter 4, utilizing a new software tool to look at strain throughout the left ventricle, and also to explore the relationship between strain and myocardial fibrosis. The results show that there are significant variations in circumferential strain measurements, depending on slice position in the LV, and also that there was no relationship found between strain and the degree of LV fibrosis. In chapter 5, the potential of CMR T1 mapping to identify fibrosis is examined using a new shortened non-contrast sequence (ShMOLLI - Shortened Modified Look-Locker Inversion) developed in our unit. CMR T1 values were validated against histological quantification of myocardial fibrosis in a large group of moderate and asymptomatic AS. A good correlation was found between ShMOLLI derived T1 values, with T1 values increasing with the severity of AS. The clinical value of measuring myocardial perfusion and LV global strain is examined in chapter 6 by linking these to prognosis. Measurement of circumferential strain could predict prognosis in asymptomatic AS, but myocardial perfusion showed poor ability to predict events. In conclusion, this thesis offers further insights into the changes that occur in the myocardium of patients with asymptomatic moderate and severe AS, using established and new CMR techniques. The clinical value of measuring these CMR parameters to aid risk stratification is shown, and the future potential for monitoring new therapies in these patients is discussed in the final chapter.

Subjects/Keywords: 616.138; Cardiovascular disease; Aortic stenosis; physiology; myocardium

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bull, S. C. (2012). Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588388

Chicago Manual of Style (16^th Edition):

Bull, Sacha Colette. “Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis.” 2012. Doctoral Dissertation, University of Oxford. Accessed March 02, 2021. http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588388.

MLA Handbook (7^th Edition):

Bull, Sacha Colette. “Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis.” 2012. Web. 02 Mar 2021.

Vancouver:

Bull SC. Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis. [Internet] [Doctoral dissertation]. University of Oxford; 2012. [cited 2021 Mar 02]. Available from: http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588388.

Council of Science Editors:

Bull SC. Aortic stenosis : pathophysiological effects on the myocardium and predictors of clinical events : physiology of the myocardium in aortic stenosis. [Doctoral Dissertation]. University of Oxford; 2012. Available from: http://ora.ox.ac.uk/objects/uuid:a05f5eea-ae68-43a5-84b3-d9a0a1ee40ce ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588388

University of Alberta

8. Reinhart, Chance W. The effect of exercise training on metaboreflex regulation of heart rate and blood pressure.

Degree: MS, Physical Education and Recreation, 2015, University of Alberta

URL: https://era.library.ualberta.ca/files/7s75dg163

► The metaboreflex is a cardiovascular reflex which activates the sympathetic nervous system when a mismatch between oxygen delivery and demand occurs during exercise; metabolic by-products… (more)

▼ The metaboreflex is a cardiovascular reflex which activates the sympathetic nervous system when a mismatch between oxygen delivery and demand occurs during exercise; metabolic by-products accumulate in the interstitium of skeletal muscle tissue and stimulate afferent nerve fibers. This in turn elevates heart rate and blood pressure by increasing cardiac output as well as peripheral vasoconstriction. This thesis investigated the effects of exercise training on metaboreflex regulation of heart rate and blood pressure during dynamic exercise in healthy humans. It was hypothesized that activation of the metaboreflex would produce a smaller increase in heart rate and blood pressure during exercise following aerobic exercise training. Young males (age=24.7±3.9) were assigned to traditional aerobic (n=10) or sprint interval (SPRI n=15) exercise training on a cycle ergometer. The traditional aerobic training group trained five days/week for six weeks at a workload that elicited 75% of maximum heart rate for a flywheel distance of 16 km. The sprint interval training group performed repeats of 30 s bouts of exercise at a resistance equal to 7.5% of the subject’s body weight on three days/week for six weeks. Each exercise bout was separated by 4.5 minutes of cycling with minimal resistance to allow for recovery. Young males performed steady-state recumbent cycling exercise at 60% of maximum heart rate in control and partial flow-restricted conditions before and after traditional aerobic and sprint interval exercise training. Once heart rate achieved steady-state, pneumatic leg cuffs were inflated to partially restrict leg blood flow during exercise and stimulate the metaboreflex. Heart rate and blood pressure were measured continuously measured via finger-cuff photo-plethysmography. Traditional aerobic and sprint interval exercise training both improved aerobic fitness (PRE: TRAD-50.3±10.6 mL/kg/min., SPRI-48.7±9.5 kg/mL/min.; POST: TRAD-53.5±8.0 mL/kg/min., SPRI-50.3±8.4 mL/kg/min.) and peak power output (PRE: TRAD-305±35W., SPRI-289±52 W; POST: TRAD-325±33 W L/min., SPRI-312±52 W). However, neither traditional aerobic nor sprint interval exercise training altered the heart rate and mean arterial pressure response to metaboreflex activation in either the exercise trained legs (ΔHR - PRE:TRAD- 7.7±4.9 bpm, SPRI- 7.4±5.8 bpm; POST: TRAD- 6.9±3.3 bpm, SPRI- 7.2±3.4 bpm)(ΔMAP- PRE: TRAD- 11.1±6.0 mmHg, SPRI- 7.3±5.6 mmHg; POST: TRAD- 12.1±6.7 mmHg, SPRI - 8.9±4.3 mmHg) or the untrained forearm (ΔHR- PRE: TRAD- 0.4±10.7 bpm, SPRI- -2.3±8.4 bpm; POST: TRAD- -3.2±9.7 bpm, SPRI- -2.51±9.8 mmHg)(ΔMAP - PRE: TRAD- 18.3±13.2 mmHg, SPRI- 23.3±10.5 mmHg; POST: TRAD- 15.3±14.0 mmHg, SPRI- 23.5±9.1 mmHg). In conclusion, exercise training did not alter the magnitude of the heart rate and blood pressure response to metaboreflex activation during exercise in healthy young males.

Subjects/Keywords: Exercise Training; Cardiovascular Physiology; Exercise Physiology; Metaboreflex; High-Intensity Interval Training

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APA (6^th Edition):

Reinhart, C. W. (2015). The effect of exercise training on metaboreflex regulation of heart rate and blood pressure. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/7s75dg163

Chicago Manual of Style (16^th Edition):

Reinhart, Chance W. “The effect of exercise training on metaboreflex regulation of heart rate and blood pressure.” 2015. Masters Thesis, University of Alberta. Accessed March 02, 2021. https://era.library.ualberta.ca/files/7s75dg163.

MLA Handbook (7^th Edition):

Reinhart, Chance W. “The effect of exercise training on metaboreflex regulation of heart rate and blood pressure.” 2015. Web. 02 Mar 2021.

Vancouver:

Reinhart CW. The effect of exercise training on metaboreflex regulation of heart rate and blood pressure. [Internet] [Masters thesis]. University of Alberta; 2015. [cited 2021 Mar 02]. Available from: https://era.library.ualberta.ca/files/7s75dg163.

Council of Science Editors:

Reinhart CW. The effect of exercise training on metaboreflex regulation of heart rate and blood pressure. [Masters Thesis]. University of Alberta; 2015. Available from: https://era.library.ualberta.ca/files/7s75dg163

UCLA

9. Packard, Rene Rupen Sevag. Advanced Imaging and Bioengineering Approaches to Cardiovascular Disease.

Degree: Molec, Cell, & Integ Physiology, 2016, UCLA

URL: http://www.escholarship.org/uc/item/1g87k0w0

► Light Sheet Fluorescence Microscopy enables multi-dimensional and multi-scale imaging via illuminating specimens with a separate thin sheet of laser. It allows rapid plane illumination for… (more)

▼ Light Sheet Fluorescence Microscopy enables multi-dimensional and multi-scale imaging via illuminating specimens with a separate thin sheet of laser. It allows rapid plane illumination for reduced photo-damage and superior axial resolution and contrast. By combining our approach with tissue clearing techniques, we reveal the entire cardiac structures and hypertrabeculation of adult zebrafish hearts in response to doxorubicin chemotherapy treatment. We incorporate light-sheet fluorescent microscopy and pulsed-wave Doppler ultrasound to unravel the 3D architecture and electromechanical coupling of doxorubicin-induced cardiac injury and regeneration in the adult zebrafish model. 3-month old zebrafish were injected intraperitoneally with doxorubicin followed by imaging at 3, 30, and 60 days post-injection. We observed an initial decrease in myocardial and endocardial cavity volume at day 3, followed by ventricular remodeling and hypertrabeculation at day 30, and normalization at day 60. Doxorubicin-injected fish developed ventricular diastolic dysfunction evidenced by elevated E/A ratios at day 30, normalizing at day 60. Myocardial performance indexes were also elevated at day 30 in the doxorubicin group, indicating worsening of global cardiac function, followed by normalization at day 60. qRT-PCR to investigate the pathways involved revealed up-regulation of Notch signaling genes, particularly the ligand Jagged1 and target gene HEY2 at days 30 and 60. Treatment with the γ-secretase inhibitor DAPT to inhibit Notch signaling attenuated restoration of ventricular function, demonstrated by persistence of abnormal E/A ratios and myocardial performance indexes at day 60, thereby implicating Notch pathways in the cardiac regeneration process. Our results suggest that doxorubicin-induced cardiac injury leads to ventricular remodeling, followed by activation of Notch signaling to promote hypertrabeculation and restoration of cardiac function. Next, we developed and studied invasive, and non-invasive imaging approaches to characterize atherosclerotic plaques. Four-point electrode systems are commonly used for electric impedance measurements of biomaterials and tissues. We introduced a 2-point system to reduce electrode polarization for heterogeneous measurements of vascular wall. Presence of endoluminal oxidized low density lipoprotein (oxLDL) and lipids alters the electrochemical impedance that can be measured by electrochemical impedance spectroscopy (EIS). We developed a catheter-based 2-point micro-electrode configuration for intravascular deployment in New Zealand White rabbits. An array of 2 flexible round electrodes, 240 ï¿½m in diameter and separated by 400 ï¿½m was microfabricated and mounted on an inflatable balloon catheter for EIS measurement of the oxLDL-rich lesions developed as a result of high-fat diet-induced hyperlipidemia. Upon balloon inflation, the 2-point electrode array conformed to the arterial wall to allow deep intraplaque penetration via alternating current. The frequency sweep from 10…

Subjects/Keywords: Physiology; Biomedical engineering; Bioengineering; Cardiovascular Disease; Imaging; Integrative Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Packard, R. R. S. (2016). Advanced Imaging and Bioengineering Approaches to Cardiovascular Disease. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/1g87k0w0

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Packard, Rene Rupen Sevag. “Advanced Imaging and Bioengineering Approaches to Cardiovascular Disease.” 2016. Thesis, UCLA. Accessed March 02, 2021. http://www.escholarship.org/uc/item/1g87k0w0.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Packard, Rene Rupen Sevag. “Advanced Imaging and Bioengineering Approaches to Cardiovascular Disease.” 2016. Web. 02 Mar 2021.

Vancouver:

Packard RRS. Advanced Imaging and Bioengineering Approaches to Cardiovascular Disease. [Internet] [Thesis]. UCLA; 2016. [cited 2021 Mar 02]. Available from: http://www.escholarship.org/uc/item/1g87k0w0.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Packard RRS. Advanced Imaging and Bioengineering Approaches to Cardiovascular Disease. [Thesis]. UCLA; 2016. Available from: http://www.escholarship.org/uc/item/1g87k0w0

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arkansas

10. Caldwell, Aaron Richard. Influence of Heating and Biological Sex on Vascular Dysfunction Associated with Long-Duration Sitting and Standing.

Degree: PhD, 2019, University of Arkansas

URL: https://scholarworks.uark.edu/etd/3407

► Purpose: The purpose of these studies was to determine if arterial angulations (through sitting or standing), shear stress (through local heating), or a combination… (more)

▼ Purpose: The purpose of these studies was to determine if arterial angulations (through sitting or standing), shear stress (through local heating), or a combination of these factors affected vascular function. Moreover, this studied estimated the magnitude of the effect that biological sex has on these vascular responses. Methods: Twenty-six healthy, young (18-40 years old) males (n=13) and females (n=13) completed two experimental trials (2-h sitting and 2-h standing). In a randomized fashion, one leg was passively heated in order to increase shear rate. Following a 48-h washout, participants returned to the laboratory to complete the other trial. Flow-mediated dilation (FMD) at the superficial femoral artery (SFA), and central and peripheral pulse-wave velocity (PWV) were measured using vascular ultrasound. Endothelin-1 (ET-1) was analyzed using an enzyme-linked immunoassay (ELISA). Results: There was a non-significant decrease in FMD (1.45%; p = .06) during sitting and the decline in FMD was not different between biological sexes (p > .05). Further, standing resulted in a significant increase in peripheral PWV (50 cm/s; p < .05) but there was no change during sitting (p > .05). Overall, passive heating (1.42%; p < .05) and standing (1.42%; p < .05) both independently improved FMD in comparison to sitting. However, neither intervention attenuated the increases in peripheral PWV that occurred during standing (p > .05). ET-1 did not increase over the course of either trial and was not different between sexes (p > .05). Antegrade shear rate increased (p < .001) and retrograde stress decreased (p < .001) when passively heated. Further, there was vasoconstriction during standing with SFA diameter decreasing compared to sitting (0.28 mm; p < .001). Conclusions: Both interventions, passive heating and standing, appear to be equally effective at improving FMD. Further, we demonstrate that there is no significant impact of biological sex on sitting induced vascular dysfunction and the interventions intended to prevent this dysfunction. However, standing increased peripheral PWV and passive heating did not attenuate this response. Advisors/Committee Members: Matthew S. Ganio, Ronna Turner, Erin Howie.

Subjects/Keywords: cardiovascular; health; physiology; vascular dysfunction; arterial angulations; Circulatory and Respiratory Physiology; Exercise Physiology; Exercise Science

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APA (6^th Edition):

Caldwell, A. R. (2019). Influence of Heating and Biological Sex on Vascular Dysfunction Associated with Long-Duration Sitting and Standing. (Doctoral Dissertation). University of Arkansas. Retrieved from https://scholarworks.uark.edu/etd/3407

Chicago Manual of Style (16^th Edition):

Caldwell, Aaron Richard. “Influence of Heating and Biological Sex on Vascular Dysfunction Associated with Long-Duration Sitting and Standing.” 2019. Doctoral Dissertation, University of Arkansas. Accessed March 02, 2021. https://scholarworks.uark.edu/etd/3407.

MLA Handbook (7^th Edition):

Caldwell, Aaron Richard. “Influence of Heating and Biological Sex on Vascular Dysfunction Associated with Long-Duration Sitting and Standing.” 2019. Web. 02 Mar 2021.

Vancouver:

Caldwell AR. Influence of Heating and Biological Sex on Vascular Dysfunction Associated with Long-Duration Sitting and Standing. [Internet] [Doctoral dissertation]. University of Arkansas; 2019. [cited 2021 Mar 02]. Available from: https://scholarworks.uark.edu/etd/3407.

Council of Science Editors:

Caldwell AR. Influence of Heating and Biological Sex on Vascular Dysfunction Associated with Long-Duration Sitting and Standing. [Doctoral Dissertation]. University of Arkansas; 2019. Available from: https://scholarworks.uark.edu/etd/3407

11. LeBrun, Kristen Anne. Effects Of A Six-Week Functional Training Program On Fitness And Body Composition Of Fire Science Majors.

Degree: MS, Exercise and Sport Science, 2015, Encompass Digital Archive, Eastern Kentucky University

URL: https://encompass.eku.edu/etd/391

► Introduction: The leading cause of on duty death of firefighters is sudden cardiac events. Current research has shown the effects of fire physical training… (more)

Subjects/Keywords: body composition; cardiovascular; firefighter; fitness; functional fitness; physical performance; Cardiovascular Diseases; Exercise Physiology

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APA (6^th Edition):

LeBrun, K. A. (2015). Effects Of A Six-Week Functional Training Program On Fitness And Body Composition Of Fire Science Majors. (Masters Thesis). Encompass Digital Archive, Eastern Kentucky University. Retrieved from https://encompass.eku.edu/etd/391

Chicago Manual of Style (16^th Edition):

LeBrun, Kristen Anne. “Effects Of A Six-Week Functional Training Program On Fitness And Body Composition Of Fire Science Majors.” 2015. Masters Thesis, Encompass Digital Archive, Eastern Kentucky University. Accessed March 02, 2021. https://encompass.eku.edu/etd/391.

MLA Handbook (7^th Edition):

LeBrun, Kristen Anne. “Effects Of A Six-Week Functional Training Program On Fitness And Body Composition Of Fire Science Majors.” 2015. Web. 02 Mar 2021.

Vancouver:

LeBrun KA. Effects Of A Six-Week Functional Training Program On Fitness And Body Composition Of Fire Science Majors. [Internet] [Masters thesis]. Encompass Digital Archive, Eastern Kentucky University; 2015. [cited 2021 Mar 02]. Available from: https://encompass.eku.edu/etd/391.

Council of Science Editors:

LeBrun KA. Effects Of A Six-Week Functional Training Program On Fitness And Body Composition Of Fire Science Majors. [Masters Thesis]. Encompass Digital Archive, Eastern Kentucky University; 2015. Available from: https://encompass.eku.edu/etd/391

Michigan Technological University

12. Greenlund, Ian. Workplace Standing Desks and Arterial Stiffness.

Degree: MS, Department of Biological Sciences, 2018, Michigan Technological University

URL: https://digitalcommons.mtu.edu/etdr/582

► Many jobs in today’s society require sitting at a desk with little physical activity. Individuals who engage in ten hours of sedentary behavior per… (more)

Subjects/Keywords: Alternative Workstations; Energy Expenditure; Cardiovascular Health; Cardiovascular Diseases; Circulatory and Respiratory Physiology

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APA (6^th Edition):

Greenlund, I. (2018). Workplace Standing Desks and Arterial Stiffness. (Masters Thesis). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/582

Chicago Manual of Style (16^th Edition):

Greenlund, Ian. “Workplace Standing Desks and Arterial Stiffness.” 2018. Masters Thesis, Michigan Technological University. Accessed March 02, 2021. https://digitalcommons.mtu.edu/etdr/582.

MLA Handbook (7^th Edition):

Greenlund, Ian. “Workplace Standing Desks and Arterial Stiffness.” 2018. Web. 02 Mar 2021.

Vancouver:

Greenlund I. Workplace Standing Desks and Arterial Stiffness. [Internet] [Masters thesis]. Michigan Technological University; 2018. [cited 2021 Mar 02]. Available from: https://digitalcommons.mtu.edu/etdr/582.

Council of Science Editors:

Greenlund I. Workplace Standing Desks and Arterial Stiffness. [Masters Thesis]. Michigan Technological University; 2018. Available from: https://digitalcommons.mtu.edu/etdr/582

Michigan State University

13. Li, Ying. Identification of the total peripheral resistance baroreflex.

Degree: MS, Department of Electrical Engineering, 2005, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:33560

Subjects/Keywords: Hypertension; Baroreflexes – Physiology; Cardiovascular system – Physiology

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APA (6^th Edition):

Li, Y. (2005). Identification of the total peripheral resistance baroreflex. (Masters Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:33560

Chicago Manual of Style (16^th Edition):

Li, Ying. “Identification of the total peripheral resistance baroreflex.” 2005. Masters Thesis, Michigan State University. Accessed March 02, 2021. http://etd.lib.msu.edu/islandora/object/etd:33560.

MLA Handbook (7^th Edition):

Li, Ying. “Identification of the total peripheral resistance baroreflex.” 2005. Web. 02 Mar 2021.

Vancouver:

Li Y. Identification of the total peripheral resistance baroreflex. [Internet] [Masters thesis]. Michigan State University; 2005. [cited 2021 Mar 02]. Available from: http://etd.lib.msu.edu/islandora/object/etd:33560.

Council of Science Editors:

Li Y. Identification of the total peripheral resistance baroreflex. [Masters Thesis]. Michigan State University; 2005. Available from: http://etd.lib.msu.edu/islandora/object/etd:33560

Macquarie University

14. Le, Sheng. Functional properties, neurochemistry and connectivity of medullary neural networks that control breathing and circulation.

Degree: 2016, Macquarie University

URL: http://hdl.handle.net/1959.14/1254517

►

Empirical thesis.

Bibliography: pages 144-188.

1. Introduction – 2. Recording, labelling and transfection of single neurons in deep brain structures – 3. Somatostatin 2a receptors… (more)

▼

Empirical thesis.

Bibliography: pages 144-188.

1. Introduction – 2. Recording, labelling and transfection of single neurons in deep brain structures – 3. Somatostatin 2a receptors are not expressed on functionally identified respiratory neurons in the ventral respiratory column of the rat – 4. The connectome of rostral ventrolateral medulla C1 neurons – 5. General discussion – References – Appendices.

The autonomic nervous system governs basic homeostatic functions such as regulating cardiac output, blood pressure, body temperature, and the generation of respiratory rhythm. Although traditionally conceptualised as independent entities, the neural networks that underlie respiratory rhythm and vasomotor tone are intimately connected, with each component influencing the activity of the other. This respiratory-sympathetic coupling contributes to cardiac sinus arrhythmia and underlies the strong respiratory modulation of vasomotor sympathetic nerve activity, which may play an important role in initiation and development of neurogenic hypertension. The experiments described in this thesis explore the neurochemical profiles, functional properties, and circuit architecture of medullary neurons that control breathing and circulation.

Genetically modifying a single functionally identified neuron in an intact neural network would provide the ultimate way to bridge neuronal circuit structure and function. The work described in Chapter 2 of this thesis describes a novel method that combines extracellular recording with the labelling of neurons recorded in the ventral lateral medulla with either dyes or plasmid DNA, permitting conventional cell labelling or gene delivery. We demonstrate that our approach has several advantages over traditional single-cell labelling approaches, and therefore provides a useful tool for correlation of functional properties of single neurons with their neurochemical phenotypes that can also be used for targeted single cell gene delivery under blind recording conditions.

We then apply this technique to address a controversial topic in the field of respiratory neuroscience; the neurochemical signature of the neurons responsible for generating respiratory rhythm. Previous investigations have suggested that the neuropeptide somatostatin plays a critical role in respiratory rhythmogenesis and is a marker for excitatory respiratory interneurons in the pre-Bötzinger complex (preBötC). Somatostatin receptor type 2a (sst₂ₐ) has been postulated as a mediator of such effects, and has also been proposed as a marker for respiratory neurons. In Chapter 3 we systematically examine the expression pattern of sst₂ₐ with regards to the functionally distinguished subcomponents of the ventral respiratory column. We further examine the feasibility of sst₂ₐ as a reliable marker of respiratory function at the single cell level.

In Chapter 4 we examine the anatomical substrate responsible for linking the respiratory and sympathetic circuits using a modified trans-synaptic tracing tool. We first…

Advisors/Committee Members: Macquarie University. Department of Biomedical Sciences.

Subjects/Keywords: Neurons – Physiology; Neurons – Ultrastructure; Medulla oblongata – Physiology; connectome; autonomic neuroscience; respiration; cardiovascular control

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APA (6^th Edition):

Le, S. (2016). Functional properties, neurochemistry and connectivity of medullary neural networks that control breathing and circulation. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1254517

Chicago Manual of Style (16^th Edition):

Le, Sheng. “Functional properties, neurochemistry and connectivity of medullary neural networks that control breathing and circulation.” 2016. Doctoral Dissertation, Macquarie University. Accessed March 02, 2021. http://hdl.handle.net/1959.14/1254517.

MLA Handbook (7^th Edition):

Le, Sheng. “Functional properties, neurochemistry and connectivity of medullary neural networks that control breathing and circulation.” 2016. Web. 02 Mar 2021.

Vancouver:

Le S. Functional properties, neurochemistry and connectivity of medullary neural networks that control breathing and circulation. [Internet] [Doctoral dissertation]. Macquarie University; 2016. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1959.14/1254517.

Council of Science Editors:

Le S. Functional properties, neurochemistry and connectivity of medullary neural networks that control breathing and circulation. [Doctoral Dissertation]. Macquarie University; 2016. Available from: http://hdl.handle.net/1959.14/1254517

Temple University

15. Richards, Jamie Madison. The Potential of IL-19 As a Therapeutic Anti-inflammatory and Angiogenic Cytokine.

Degree: PhD, 2015, Temple University

URL: http://digital.library.temple.edu/u?/p245801coll10,345114

►

Physiology

Our lab has recently shown that IL-19 is expressed in angiogenic ECs, opening the possibility for its use as a medicine to increase perfusion… (more)

▼

Physiology

Our lab has recently shown that IL-19 is expressed in angiogenic ECs, opening the possibility for its use as a medicine to increase perfusion in patients with PAD. The first aim of the current study is to show IL-19’s ability to increase perfusion in vivo using C57BL/6 wild type and IL-19 KO mice in the hindlimb ischemia (HLI) model. Wild-type mice injected with 10ng/g/day of rmIL-19 after being subject to hindlimb ischemia showed significantly greater levels of perfusion than PBS injected littermates. Immunohistochemistry of harvested gastrocnemius muscle showed a greater level of capillary density in IL-19 injected mice as well. IL-19-/- mice also showed a slower recovery of perfusion in a ligated limb in addition to less CD31 positive cells in gastrocnemius muscle when compared to C57BL/6 wild type mice. IL-19 -/- mice also showed increased perfusion when injected with rmIL-19. The second aim of the study is to show more precisely if IL-19 increases angiogenesis by increasing angiogenic cytokine production, polarizing macrophage phenotype, or by influencing angiogenic and anti-angiogenic factors. Spleen, serum, and bone marrow derived macrophage (BMDM) from mouse models used in Aim 1 showed increased levels of angiogenic cytokines, decreased anti-angiogenic cytokines, and markers of M2 macrophage polarization when IL-19 was injected i.p. or present genetically. The third aim of the study examines whether or not IL-19 can increase perfusion within an atherosclerotic background. It also addresses whether IL-19 can both simultaneously reduce atherosclerosis and increase perfusion. This aim also uses mice lacking LDLR-/- genes to further evaluate these questions. LDLR-/- mice fed a high fat diet for 12 weeks underwent HLI and had perfusion levels measured using Doppler imaging in addition to four weeks of 10ng/g/day of IL-19 or PBS injections. Upon sacrifice mice also had their aortas harvested and stained for plaque measurement. This experiment seeks to demonstrate if IL-19 can increase perfusion on an atherosclerotic background. Additionally, a second set of experiments addresses if LDLR-/- mice injected with recombinant mouse IL-19 (rmIL-19) or PBS for 16 weeks on a HFD in addition to HLI being performed at week 12 showed decreased levels of plaque and increased levels of hindlimb perfusion. These experiments seek to demonstrate if IL-19 can simultaneously reduce atherosclerosis while increasing perfusion. A third set of experiments attempts to evaluate the hypothesis that double knock out mice (DKO) lacking both LDLR and IL-19 genes will have increased plaque after being fed a HFD for 16 weeks. These aims all support the overall hypothesis that IL-19 can increase angiogenesis while additionally proving to be anti-inflammatory and anti-atherogenic in vivo

Temple University – Theses

Advisors/Committee Members: Autieri, Michael V.;, Scalia, Rosario, Kilpatrick, Laurie, Rizzo, Victor, Yang, Xiao-Feng;.

Subjects/Keywords: Physiology; Health sciences; Medicine;

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APA (6^th Edition):

Richards, J. M. (2015). The Potential of IL-19 As a Therapeutic Anti-inflammatory and Angiogenic Cytokine. (Doctoral Dissertation). Temple University. Retrieved from http://digital.library.temple.edu/u?/p245801coll10,345114

Chicago Manual of Style (16^th Edition):

Richards, Jamie Madison. “The Potential of IL-19 As a Therapeutic Anti-inflammatory and Angiogenic Cytokine.” 2015. Doctoral Dissertation, Temple University. Accessed March 02, 2021. http://digital.library.temple.edu/u?/p245801coll10,345114.

MLA Handbook (7^th Edition):

Richards, Jamie Madison. “The Potential of IL-19 As a Therapeutic Anti-inflammatory and Angiogenic Cytokine.” 2015. Web. 02 Mar 2021.

Vancouver:

Richards JM. The Potential of IL-19 As a Therapeutic Anti-inflammatory and Angiogenic Cytokine. [Internet] [Doctoral dissertation]. Temple University; 2015. [cited 2021 Mar 02]. Available from: http://digital.library.temple.edu/u?/p245801coll10,345114.

Council of Science Editors:

Richards JM. The Potential of IL-19 As a Therapeutic Anti-inflammatory and Angiogenic Cytokine. [Doctoral Dissertation]. Temple University; 2015. Available from: http://digital.library.temple.edu/u?/p245801coll10,345114

University of Saskatchewan

16. Sundarrajan, Lakshminarasimhan 1989-. Novel Regulators of Feeding and Cardiovascular Physiology in Fish.

Degree: 2018, University of Saskatchewan

URL: http://hdl.handle.net/10388/8583

► Nesfatin-1, an 82 amino acid anorexigen is encoded in a secreted precursor, nucleobindin-2 (NUCB2). NUCB2 was named so due to its high sequence similarity with… (more)

▼ Nesfatin-1, an 82 amino acid anorexigen is encoded in a secreted precursor, nucleobindin-2 (NUCB2). NUCB2 was named so due to its high sequence similarity with nucleobindin-1 (NUCB1). It was recently reported that NUCB1 encodes an insulinotropic nesfatin-1-like peptide (NLP) in mice. Irisin, a muscle protein is encoded in its precursor fibronectin type III domain containing 5 (FNDC5) and released into blood from skeletal muscle. Here we aimed to characterize NLP and irisin in fish, and to study whether these are novel regulators of feeding and cardiovascular functions in zebrafish and goldfish. Western blot analysis and immunohistochemical studies determined the expression of NUCB1/NLP in central and peripheral tissues of goldfish. Administration of rat and goldfish NLP at 10 and 100 ng/g body weight doses caused potent inhibition of food intake in goldfish. NLP also downregulated the expression of preproghrelin and orexin-A mRNA, and upregulated cocaine and amphetamine regulated transcript (CART) mRNA in goldfish brain. Intraperitoneal (I.P) administration of NLP reduced cardiac functions in zebrafish and goldfish, downregulated irisin, and RyR1b mRNA expression in zebrafish. Irisin was detected in zebrafish heart and skeletal muscle. Single I.P. injection of irisin did not affect feeding, but its knockdown using siRNA caused a significant reduction in food intake. Knockdown of irisin reduced ghrelin and orexin-A mRNA expression, and increased CART mRNA expression in zebrafish brain and gut. Meanwhile, injection of irisin (0.1 and 1 ng/g B.W) increased cardiac functions, while knockdown of irisin resulted in reverse effects on cardiovascular physiology. Administration of propranolol attenuated the effects of irisin on cardiac physiology. Collectively, my research discovered that NLP and irisin modulate food intake and cardiac physiology in fish. Future studies should focus on the mechanisms of action of NLP and irisin in regulating metabolism and cardiovascular biology in fish. Advisors/Committee Members: Unniappan, Suraj, MacPhee, Daniel, Weber , Lynn, Ferrari , Maud, Hogan , Natacha.

Subjects/Keywords: Nesfatin-1-Like Peptide; Irisin; Feeding; Cardiovascular Physiology

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APA (6^th Edition):

Sundarrajan, L. 1. (2018). Novel Regulators of Feeding and Cardiovascular Physiology in Fish. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/8583

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sundarrajan, Lakshminarasimhan 1989-. “Novel Regulators of Feeding and Cardiovascular Physiology in Fish.” 2018. Thesis, University of Saskatchewan. Accessed March 02, 2021. http://hdl.handle.net/10388/8583.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sundarrajan, Lakshminarasimhan 1989-. “Novel Regulators of Feeding and Cardiovascular Physiology in Fish.” 2018. Web. 02 Mar 2021.

Vancouver:

Sundarrajan L1. Novel Regulators of Feeding and Cardiovascular Physiology in Fish. [Internet] [Thesis]. University of Saskatchewan; 2018. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10388/8583.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sundarrajan L1. Novel Regulators of Feeding and Cardiovascular Physiology in Fish. [Thesis]. University of Saskatchewan; 2018. Available from: http://hdl.handle.net/10388/8583

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

17. Skaria, Rinku. Machine Learning and Deep Phenotyping Towards Predictive Analytics and Therapeutic Strategy in Cardiac Surgery .

Degree: 2020, University of Arizona

URL: http://hdl.handle.net/10150/642197

► Introduction: Myocardial infarction (MI) secondary to coronary artery disease (CAD) remains the most common cause of heart failure (HF), costing over $30 billion in healthcare… (more)

▼ Introduction: Myocardial infarction (MI) secondary to coronary artery disease (CAD) remains the most common cause of heart failure (HF), costing over $30 billion in healthcare costs. Although early revascularization is the most effective therapy to restore blood flow and salvage myocardium, to date, there are no available treatments to attenuate ischemia-reperfusion injury (IRI). Moreover, post-operative atrial fibrillation (POAF) continues to be a devastating complication following cardiac surgery, affecting 25-40% CABG and 30-40% valve patients. Human placental amniotic (HPA) tissue is known to have anti-inflammatory and wound healing properties and therefore may promote anti-arrhythmic and cardioprotective effects in patients undergoing cardiac surgery. The central hypothesis of this study is the use of predictive modeling in conjunction with HPA application improves cardioprotection against IRI and POAF following cardiac surgery. Methods: We developed predictive models for POAF using machine learning to characterize 340,860 isolated CABG patients from 2014 to 2017 from the national Society of Thoracic Surgeons database. The support-vector machine (SVM) models were assessed based on accuracy, sensitivity, and specificity, and the neural network (NN) model was compared to the currently utilized CHA2DS2-VASc score. Additionally, using a clinically relevant model of IRI, we performed an unbiased, non-hypothesis driven transcriptome and proteome analysis to elucidate cellular and molecular mechanisms of HPA xenograft-induced cardioprotection against IRI. Swine (n=3 in MI only and MI+HPA groups) were subjected to a 45-minute percutaneous IRI protocol followed by HPA placement in the treated group. Cardiac function was assessed, and tissue samples were collected post-operative day 14. Results were further supported by histology, RT-PCR, and Western blot analyses. Lastly, a retrospective study of 78 isolated CABG and 47 isolated valve patients were evaluated to determine if HPA use on the epicardial surface decreases incidence of POAF. Results: Predictive modeling using neural networks demonstrated to outperform the CHA2DS2-VASc score in predicting POAF in CABG patients. Second, we present the first comprehensive transcriptome and proteome profiles of the ischemic, border, and remote myocardium during the proliferative cardiac repair phase with HPA allograft use in swine. Our results establish HPA limited the extent of cardiac injury by 50% and preserved cardiac function. Spatial dynamic responses, as well as coordinated immune and extracellular matrix remodeling to mitigate injury, were among the key findings. Changes in protein secretion, mitochondrial bioenergetics, and inflammatory responses were also noted to contribute to cardioprotection. Third, peri-operative HPA allograft placement has demonstrated a strong reduction in the incidence of POAF following CABG and valve surgery. Discussion: We provide convincing evidence that HPA has beneficial effects on injured myocardium and POAF and can serve as a new… Advisors/Committee Members: Konhilas, John P (advisor), Runyan, Raymond B. (committeemember), Antin, Parker B. (committeemember), Langlais, Paul R. (committeemember), Churko, Jared (committeemember).

Subjects/Keywords: cardiac physiology; cardiovascular disease; ischemia-reperfusion injury; post-operative atrial fibrillation

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APA (6^th Edition):

Skaria, R. (2020). Machine Learning and Deep Phenotyping Towards Predictive Analytics and Therapeutic Strategy in Cardiac Surgery . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/642197

Chicago Manual of Style (16^th Edition):

Skaria, Rinku. “Machine Learning and Deep Phenotyping Towards Predictive Analytics and Therapeutic Strategy in Cardiac Surgery .” 2020. Doctoral Dissertation, University of Arizona. Accessed March 02, 2021. http://hdl.handle.net/10150/642197.

MLA Handbook (7^th Edition):

Skaria, Rinku. “Machine Learning and Deep Phenotyping Towards Predictive Analytics and Therapeutic Strategy in Cardiac Surgery .” 2020. Web. 02 Mar 2021.

Vancouver:

Skaria R. Machine Learning and Deep Phenotyping Towards Predictive Analytics and Therapeutic Strategy in Cardiac Surgery . [Internet] [Doctoral dissertation]. University of Arizona; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10150/642197.

Council of Science Editors:

Skaria R. Machine Learning and Deep Phenotyping Towards Predictive Analytics and Therapeutic Strategy in Cardiac Surgery . [Doctoral Dissertation]. University of Arizona; 2020. Available from: http://hdl.handle.net/10150/642197

UCLA

18. Hsu, Jeffrey John. Light-Sheet Fluorescence Microscopy and Molecular Imaging to Elucidate Mechanisms of Cardiovascular Development and Disease.

Degree: Molec, Cell, & Integ Physiology, 2019, UCLA

URL: http://www.escholarship.org/uc/item/598489zb

► Cardiovascular development is a highly complex, coordinated process, and the investigation of the mechanisms governing this process has led to the identification of genes that… (more)

▼ Cardiovascular development is a highly complex, coordinated process, and the investigation of the mechanisms governing this process has led to the identification of genes that not only orchestrate cardiovascular development, but also modulate disease processes in adulthood. The Notch signaling pathway, for instance, has been shown to orchestrate cardiac valve development during embryogenesis, while also regulating pathological aortic valve calcification in adulthood. Therefore, a deeper understanding of the mechanisms of cardiovascular development can help inform our research into pathophysiological processes such as ectopic calcification. The studies in this dissertation utilize advanced imaging techniques to examine the mechanobiological mechanisms of cardiac valve development and disease. In the first study, four-dimensional light-sheet fluorescence microscopy imaging of embryonic zebrafish hearts was combined with moving-domain computational fluid dynamic modeling to evaluate the relative influences of contractile and hemodynamic shear forces on cardiac valve development. The results showed that contractile forces appear to be necessary for initial cardiac valve formation, whereas hemodynamic shear forces contribute to valve leaflet growth. Further, these processes appear to occur by mechanosensitive, Notch1b-mediated endothelial-to-mesenchymal transition. In the second study, fused 18F-NaF micro-positron emission tomography / micro-computed tomography (uPET/uCT) imaging was performed on aged hyperlipidemic mice to evaluate the effects of an osteoporosis therapeutic drug, teriparatide, on the morphology of aortic calcification. The evidence presented shows that while teriparatide, a parathyroid hormone analog, does not affect the progression of pre-existing aortic calcification, it promotes the coalescence of calcification into macro-calcium deposits. These studies suggest that teriparatide therapy may promote a macrocalcification phenotype in atherosclerotic calcification, with potential implications on plaque stability. In summary, these studies demonstrate the use of advanced imaging modalities, such as light-sheet microscopy and 18F-NaF-uPET/uCT imaging, to investigate the mechanobiological mechanisms of cardiovascular development, as well as cardiovascular disease, such as calcification.

Subjects/Keywords: Physiology; Developmental biology; cardiovascular calcification; light-sheet imaging; mechanobiology; valvular development

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APA (6^th Edition):

Hsu, J. J. (2019). Light-Sheet Fluorescence Microscopy and Molecular Imaging to Elucidate Mechanisms of Cardiovascular Development and Disease. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/598489zb

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hsu, Jeffrey John. “Light-Sheet Fluorescence Microscopy and Molecular Imaging to Elucidate Mechanisms of Cardiovascular Development and Disease.” 2019. Thesis, UCLA. Accessed March 02, 2021. http://www.escholarship.org/uc/item/598489zb.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hsu, Jeffrey John. “Light-Sheet Fluorescence Microscopy and Molecular Imaging to Elucidate Mechanisms of Cardiovascular Development and Disease.” 2019. Web. 02 Mar 2021.

Vancouver:

Hsu JJ. Light-Sheet Fluorescence Microscopy and Molecular Imaging to Elucidate Mechanisms of Cardiovascular Development and Disease. [Internet] [Thesis]. UCLA; 2019. [cited 2021 Mar 02]. Available from: http://www.escholarship.org/uc/item/598489zb.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hsu JJ. Light-Sheet Fluorescence Microscopy and Molecular Imaging to Elucidate Mechanisms of Cardiovascular Development and Disease. [Thesis]. UCLA; 2019. Available from: http://www.escholarship.org/uc/item/598489zb

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Moody, Jessica Ann. Development And Evaluation Of A Firefighter Physical Performance Program For Undergraduate Fire And Safety Students.

Degree: MS, Safety, Security, and Emergency Management, 2016, Encompass Digital Archive, Eastern Kentucky University

URL: https://encompass.eku.edu/etd/405

► The number one on-duty cause of death in the fire service is heart attacks. The International Association of Firefighters and the International Association of… (more)

Subjects/Keywords: firefighter; health; performance; physical; testing; Cardiovascular Diseases; Exercise Physiology

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APA (6^th Edition):

Moody, J. A. (2016). Development And Evaluation Of A Firefighter Physical Performance Program For Undergraduate Fire And Safety Students. (Masters Thesis). Encompass Digital Archive, Eastern Kentucky University. Retrieved from https://encompass.eku.edu/etd/405

Chicago Manual of Style (16^th Edition):

Moody, Jessica Ann. “Development And Evaluation Of A Firefighter Physical Performance Program For Undergraduate Fire And Safety Students.” 2016. Masters Thesis, Encompass Digital Archive, Eastern Kentucky University. Accessed March 02, 2021. https://encompass.eku.edu/etd/405.

MLA Handbook (7^th Edition):

Moody, Jessica Ann. “Development And Evaluation Of A Firefighter Physical Performance Program For Undergraduate Fire And Safety Students.” 2016. Web. 02 Mar 2021.

Vancouver:

Moody JA. Development And Evaluation Of A Firefighter Physical Performance Program For Undergraduate Fire And Safety Students. [Internet] [Masters thesis]. Encompass Digital Archive, Eastern Kentucky University; 2016. [cited 2021 Mar 02]. Available from: https://encompass.eku.edu/etd/405.

Council of Science Editors:

Moody JA. Development And Evaluation Of A Firefighter Physical Performance Program For Undergraduate Fire And Safety Students. [Masters Thesis]. Encompass Digital Archive, Eastern Kentucky University; 2016. Available from: https://encompass.eku.edu/etd/405

University of California – San Francisco

20. Weyland, Patricia G. The Evidence for Hypovitaminosis D as a Cause of Cardiovascular Disease.

Degree: Nursing, 2014, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/9fb1d99b

► The Effect of Hypovitaminosis D on Risk for Cardiovascular DiseasePatricia G. Weyland, MS, RN, FNP-BC, CDE, PhD (c)AbstractBackground: Serum 25-hydroxyvitamin D (25(OH)D) levels have been… (more)

▼ The Effect of Hypovitaminosis D on Risk for Cardiovascular DiseasePatricia G. Weyland, MS, RN, FNP-BC, CDE, PhD (c)AbstractBackground: Serum 25-hydroxyvitamin D (25(OH)D) levels have been found to be inversely associated with both prevalent and incident cardiovascular disease (CVD) risk factors; dyslipidemia, hypertension and diabetes mellitus. Objective: This review looks for evidence of a causal association between low 25(OH)D levels and increased CVD risk. Method: We evaluated journal articles in light of Hill's criteria for causality in a biological system. Results: The results of our assessment are as follows. Strength of association: many randomized controlled trials (RCTs), prospective and cross-sectional studies found statistically significant inverse associations between 25(OH)D levels and CVD risk factors. Consistency of observed association: most studies found statistically significant inverse associations between 25(OH)D levels and CVD risk factors in various populations, locations and circumstances. Temporality of association: many RCTs and prospective studies found statistically significant inverse associations between 25(OH)D levels and CVD risk factors. Biological gradient (dose-response curve): most studies assessing 25(OH)D levels and CVD risk found an inverse association exhibiting a linear biological gradient. Plausibility of biology: several plausible cellular-level causative mechanisms and biological pathways may lead from a low 25(OH)D level to increased risk for CVD with mediators, such as dyslipidemia, hypertension and diabetes mellitus. Experimental evidence: some well-designed RCTs found increased CVD risk factors with decreasing 25(OH)D levels. Analogy: the association between serum 25(OH)D levels and CVD risk is analogous to that between 25(OH)D levels and the risk of overall cancer, periodontal disease, multiple sclerosis and breast cancer. Conclusion: All relevant Hill criteria for a causal association in a biological system are satisfied to indicate a low 25(OH)D level as a CVD risk factor.

Subjects/Keywords: Nursing; Physiology; Cardiovascular Disease; Causation; Diabetes Mellitus; Dyslipidemia; Hypertension; Hypovitaminosis D

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APA (6^th Edition):

Weyland, P. G. (2014). The Evidence for Hypovitaminosis D as a Cause of Cardiovascular Disease. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/9fb1d99b

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Weyland, Patricia G. “The Evidence for Hypovitaminosis D as a Cause of Cardiovascular Disease.” 2014. Thesis, University of California – San Francisco. Accessed March 02, 2021. http://www.escholarship.org/uc/item/9fb1d99b.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Weyland, Patricia G. “The Evidence for Hypovitaminosis D as a Cause of Cardiovascular Disease.” 2014. Web. 02 Mar 2021.

Vancouver:

Weyland PG. The Evidence for Hypovitaminosis D as a Cause of Cardiovascular Disease. [Internet] [Thesis]. University of California – San Francisco; 2014. [cited 2021 Mar 02]. Available from: http://www.escholarship.org/uc/item/9fb1d99b.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Weyland PG. The Evidence for Hypovitaminosis D as a Cause of Cardiovascular Disease. [Thesis]. University of California – San Francisco; 2014. Available from: http://www.escholarship.org/uc/item/9fb1d99b

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

21. Contractor, Hussain. The role of adenosine in remote ischaemic conditioning.

Degree: PhD, 2012, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:ebb047e8-fa80-43f2-a498-0d5bfca5b138 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581174

► Strategies to reduce infarct size in ischaemia-reperfusion (IR) syndromes such as acute myocardial infarction are of high clinical and scientific interest. Remote ischaemic preconditioning (rIPC)… (more)

▼ Strategies to reduce infarct size in ischaemia-reperfusion (IR) syndromes such as acute myocardial infarction are of high clinical and scientific interest. Remote ischaemic preconditioning (rIPC) is one such strategy but its mechanisms remain incompletely understood. Multiple lines of evidence from animal studies suggest that the endogenous purine nucleoside adenosine is a key mediator of preconditioning pathways but no evidence exists as to adenosine’s role in the more complex physiology of humans. The work in this thesis aims to elucidate the role of endogenous adenosine in the physiological phenomenon of rIPC and to examine the role of exogenous adenosine in triggering preconditioning-like states. In a randomised, placebo controlled study using healthy volunteers and the human forearm model of ischaemia-reperfusion injury, I demonstrate that delivery of the adenosine receptor antagonist caffeine, prior to the initiation of a rIPC stimulus abrogates the protective effect of rIPC on IR. By then selectively infusing caffeine to achieve high local but low systemic concentrations, I also demonstrate that adenosine receptor activation is important in the ‘trigger’ phase of rIPC rather than in the ‘effector’ phase and that blockade of the trigger phase effectively inhibits the release of a circulating humoral protective factor. These studies provide evidence of the crucial role of adenosine receptor activation in human rIPC, demonstrating their sites of action and illuminating their potential mechanism of action. To study whether exogenously delivered adenosine can recapitulate preconditioning-like states, in initial studies in a large mammal model of acute myocardial infarction, I demonstrate that adenosine, given after the onset of ischaemia, but prior to reperfusion, significantly reduces myocardial infarct size. In a subsequent study, translating these findings to humans with coronary disease, I demonstrate that the delivery of adenosine in a range of concentrations is able to illicit the release of a circulating preconditioning factor which is transferrable across species and can reduce infarct size in a murine model of myocardial IR.

Subjects/Keywords: 616.12; Medical Sciences; Cardiovascular disease; Physiology; adenosine; ischaemic conditioning; cardioprotection

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APA (6^th Edition):

Contractor, H. (2012). The role of adenosine in remote ischaemic conditioning. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:ebb047e8-fa80-43f2-a498-0d5bfca5b138 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581174

Chicago Manual of Style (16^th Edition):

Contractor, Hussain. “The role of adenosine in remote ischaemic conditioning.” 2012. Doctoral Dissertation, University of Oxford. Accessed March 02, 2021. http://ora.ox.ac.uk/objects/uuid:ebb047e8-fa80-43f2-a498-0d5bfca5b138 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581174.

MLA Handbook (7^th Edition):

Contractor, Hussain. “The role of adenosine in remote ischaemic conditioning.” 2012. Web. 02 Mar 2021.

Vancouver:

Contractor H. The role of adenosine in remote ischaemic conditioning. [Internet] [Doctoral dissertation]. University of Oxford; 2012. [cited 2021 Mar 02]. Available from: http://ora.ox.ac.uk/objects/uuid:ebb047e8-fa80-43f2-a498-0d5bfca5b138 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581174.

Council of Science Editors:

Contractor H. The role of adenosine in remote ischaemic conditioning. [Doctoral Dissertation]. University of Oxford; 2012. Available from: http://ora.ox.ac.uk/objects/uuid:ebb047e8-fa80-43f2-a498-0d5bfca5b138 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.581174

Brunel University

22. Trangmar, Steven John. Circulatory limitations to exercise capacity in humans : the impact of heat stress and dehydration on brain and muscle blood flow and metabolism.

Degree: PhD, 2015, Brunel University

URL: http://bura.brunel.ac.uk/handle/2438/10609 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.646264

► Heat stress and dehydration pose a severe challenge to physiological function and the capability to perform physical work. There is, however, limited knowledge on the… (more)

▼ Heat stress and dehydration pose a severe challenge to physiological function and the capability to perform physical work. There is, however, limited knowledge on the regional haemodynamic and metabolic responses to strenuous exercise in environmentally stressful conditions. The primary aim of this thesis was to examine whether dehydration and heat stress compromise brain, muscle and systemic blood flow and metabolism, and whether depressed brain and muscle oxygen delivery underpin reduced exercise capacity during graded incremental and prolonged exercise. This thesis makes an original contribution to the knowledge by showing for the first time that dehydration markedly accelerates the decline in cerebral blood flow during maximal incremental (Chapter 4) and prolonged sub-maximal exercise (Chapter 5) in the heat. Cerebral metabolism, however, is preserved by compensatory increases in substrate extraction. Falling carbon dioxide tension underpinned the decline in CBF. However, a distinct regional distribution of blood flow across the head was observed, suggesting that different mechanisms are responsible for the regulation of regional blood flow within the head. A reduced cerebral metabolism is therefore an unlikely factor explaining the compromised exercise capacity in physiologically stressful hot environments. Rather, restrictions in active muscle blood flow and oxygen supply, which are not apparent during sub-maximal exercise, may explain the reduced maximal aerobic power in heat stressed conditions. For the first time we have manipulated skin and core temperature to show that combined internal and skin hyperthermia reduces maximal aerobic power in association with restrictions in limb, brain and systemic blood flow and skeletal muscle metabolism (Chapter 6). Overall, the findings of the present thesis provide novel information on how circulatory limitations across contracting skeletal muscle, brain and systemic tissues and organs might underpin the impairment in exercise capacity in physiologically taxing environments evoking significant dehydration and hyperthermia.

Subjects/Keywords: 613.7; Exercise; Cardiovascular physiology; Cerebral blood flow; Blood flow regulation

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APA (6^th Edition):

Trangmar, S. J. (2015). Circulatory limitations to exercise capacity in humans : the impact of heat stress and dehydration on brain and muscle blood flow and metabolism. (Doctoral Dissertation). Brunel University. Retrieved from http://bura.brunel.ac.uk/handle/2438/10609 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.646264

Chicago Manual of Style (16^th Edition):

Trangmar, Steven John. “Circulatory limitations to exercise capacity in humans : the impact of heat stress and dehydration on brain and muscle blood flow and metabolism.” 2015. Doctoral Dissertation, Brunel University. Accessed March 02, 2021. http://bura.brunel.ac.uk/handle/2438/10609 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.646264.

MLA Handbook (7^th Edition):

Trangmar, Steven John. “Circulatory limitations to exercise capacity in humans : the impact of heat stress and dehydration on brain and muscle blood flow and metabolism.” 2015. Web. 02 Mar 2021.

Vancouver:

Trangmar SJ. Circulatory limitations to exercise capacity in humans : the impact of heat stress and dehydration on brain and muscle blood flow and metabolism. [Internet] [Doctoral dissertation]. Brunel University; 2015. [cited 2021 Mar 02]. Available from: http://bura.brunel.ac.uk/handle/2438/10609 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.646264.

Council of Science Editors:

Trangmar SJ. Circulatory limitations to exercise capacity in humans : the impact of heat stress and dehydration on brain and muscle blood flow and metabolism. [Doctoral Dissertation]. Brunel University; 2015. Available from: http://bura.brunel.ac.uk/handle/2438/10609 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.646264

University of Exeter

23. Truelove, John William Stephen. The physiological effects of ingesting high sodium drinks before, during, and after exercise in the heat.

Degree: PhD, 2011, University of Exeter

URL: https://ore.exeter.ac.uk/repository/handle/10036/3274 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547084

► This thesis investigated whether highly concentrated sodium solutions ([HS] 126-164 mmol.L-1 NaCl) could provide viable strategies before during and after exercise in the heat to… (more)

▼ This thesis investigated whether highly concentrated sodium solutions ([HS] 126-164 mmol.L-1 NaCl) could provide viable strategies before during and after exercise in the heat to improve cardiovascular and thermoregulatory functioning and exercise performance. To do this it also examined the gustatory responses to HS drinks before, during and after exercise. All studies compared HS with a low sodium control ([LS] 10-27 mmol.L-1). Chapter 4 found that during 3 h recovery from dehydration, ingestion of 120 % body mass losses of HS restored fluid balance to a greater extent (121 vs. 84 %) than LS. Chapter 7 was the first to investigate the effects of ingesting HS during exercise in the heat and in an untrained population. HS attenuated the decline in stroke volume [SVDrift] and increase in heart rate [HRDrift], but did not affect rectal temperature [TRec], cardiac output, or oxygen uptake during the second of two consecutive 45 min bouts at 55% . In Chapters 8 and 9 untrained participants ingested either HS or LS during 30-45 min pre-exercise rest. HS reduced HRDrift and SVDrift but did not affect TRec during 45-60 min exercise at 10% of the difference between and gas exchange threshold [∆]. HS also increased both time to exhaustion and exercise toleranceduring subsequent exercise bouts at 60-70% ∆. Chapters 5 and 6 found that taste perceptions act as physiological regulators, in this case, one reflecting the priority to restore hyperosmolality over hypovolemia. Exercise-induced dehydration increased the palatability of water, and decreased the palatability HS, when measured before, immediately after and during 3 h recovery. The changes were highly correlated with physiological indicators of fluid balance. The ingestion of highly concentrated sodium solutions can be both an efficient and acceptable means to improve hydration, reduce cardiovascular stress, and improve exercise performance in the heat. Whilst highly effective, caution should apply since the unpleasant taste evoked by these solutions persists for at least three hours post exercise.

Subjects/Keywords: 612.015; Plasma Volume; Heat; Exercise; Sodium; Performance; Thermoregulation; Palatability; Cardiovascular; Physiology

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APA (6^th Edition):

Truelove, J. W. S. (2011). The physiological effects of ingesting high sodium drinks before, during, and after exercise in the heat. (Doctoral Dissertation). University of Exeter. Retrieved from https://ore.exeter.ac.uk/repository/handle/10036/3274 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547084

Chicago Manual of Style (16^th Edition):

Truelove, John William Stephen. “The physiological effects of ingesting high sodium drinks before, during, and after exercise in the heat.” 2011. Doctoral Dissertation, University of Exeter. Accessed March 02, 2021. https://ore.exeter.ac.uk/repository/handle/10036/3274 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547084.

MLA Handbook (7^th Edition):

Truelove, John William Stephen. “The physiological effects of ingesting high sodium drinks before, during, and after exercise in the heat.” 2011. Web. 02 Mar 2021.

Vancouver:

Truelove JWS. The physiological effects of ingesting high sodium drinks before, during, and after exercise in the heat. [Internet] [Doctoral dissertation]. University of Exeter; 2011. [cited 2021 Mar 02]. Available from: https://ore.exeter.ac.uk/repository/handle/10036/3274 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547084.

Council of Science Editors:

Truelove JWS. The physiological effects of ingesting high sodium drinks before, during, and after exercise in the heat. [Doctoral Dissertation]. University of Exeter; 2011. Available from: https://ore.exeter.ac.uk/repository/handle/10036/3274 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.547084

University of Cambridge

24. Garrud, Tessa Aimee Catriona. Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo.

Degree: PhD, 2020, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/300753

► Glucocorticoid therapy for threatened with preterm labour and in preterm neonates has become common practice in the last 40 years. This treatment is based on… (more)

▼ Glucocorticoid therapy for threatened with preterm labour and in preterm neonates has become common practice in the last 40 years. This treatment is based on the pioneering work of Liggins who discovered that development of fetal tissues was dependent upon the pre-partum surge in fetal cortisol and that exposure to synthetic glucocorticoids in premature offspring could accelerate pulmonary maturation, reducing risk of respiratory complications. Ante- and post-natal glucocorticoid therapy has since been demonstrated to significantly reduce morbidity and mortality in the preterm infant. However, several aspects of this therapy are not optimised including; drug choice (Dexamethasone, Dex, or Betamethasone, Beta), and drug formulation. There is increasing animal and human data that suggest exposure to high doses of synthetic glucocorticoids may have a detrimental effect on the fetal cardiovascular system. The chicken embryo model was used to establish a clinically relevant glucocorticoid treatment at two thirds of development, without compounding influence of maternal or placental physiology, such that the direct effect of glucocorticoid exposure on the fetal cardiovascular system could be characterised. Further to this, the model was used to assess if cardiovascular effects varied between Dex and Beta, and Beta drug formulations – phosphate or acetate. Treatment with any glucocorticoid resulted in a significant asymmetric growth restriction at term, which was more severe following Beta treatment due to the acetate formulation. Ex vivo cardiac systolic and diastolic function was impaired by all treatments, again with Beta having a more severe effect. Divergent effects in the peripheral vasculature were measured with Dex treatment inducing enhanced vasoconstriction, whereas Beta treatments impaired vasodilatation. Dex resulted in cardiomyocyte hypertrophy, whereas Beta treatments resulted in a reduction in total cardiomyocyte number. The molecular pathways activated in the embryonic heart were also divergent. Dex induced oxidative stress, cell stress pathways, caspase-3 mediated apoptosis, and p38 mediated reduced proliferation. Combined Beta treatment resulted in excessive GR activation (due to loss of negative feedback), activation of cell stress pathways, p53 mediated apoptosis and reduced proliferation. Beta acetate shared the loss of GR feedback and enhanced p53 expression, whereas Beta phosphate did not. The data presented in this thesis offer insight into mechanisms of detrimental effects of antenatal glucocorticoid therapy on the cardiovascular system and suggest it may be safer to use Dex for treatment of preterm birth.

Subjects/Keywords: cardiovascular; physiology; fetal; development; antenatal; glucocorticoids; cortisol; steroid; preterm; premature; birth

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APA (6^th Edition):

Garrud, T. A. C. (2020). Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/300753

Chicago Manual of Style (16^th Edition):

Garrud, Tessa Aimee Catriona. “Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo.” 2020. Doctoral Dissertation, University of Cambridge. Accessed March 02, 2021. https://www.repository.cam.ac.uk/handle/1810/300753.

MLA Handbook (7^th Edition):

Garrud, Tessa Aimee Catriona. “Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo.” 2020. Web. 02 Mar 2021.

Vancouver:

Garrud TAC. Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo. [Internet] [Doctoral dissertation]. University of Cambridge; 2020. [cited 2021 Mar 02]. Available from: https://www.repository.cam.ac.uk/handle/1810/300753.

Council of Science Editors:

Garrud TAC. Direct Effect of Glucocorticoids on the Developing Cardiovascular System: Studies in the Chicken Embryo. [Doctoral Dissertation]. University of Cambridge; 2020. Available from: https://www.repository.cam.ac.uk/handle/1810/300753

University of Western Ontario

25. McDonald, Matthew W. The Cardiovascular Benefits of Regular Exercise in Type 1 Diabetes Mellitus and the Risk of Exercise-induced Hypoglycemia.

Degree: 2016, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/3943

► Type 1 diabetes mellitus (T1DM) is associated with compromised glycemic control and a heightened risk for cardiovascular disease. The common treatment of T1DM with strict… (more)

▼ Type 1 diabetes mellitus (T1DM) is associated with compromised glycemic control and a heightened risk for cardiovascular disease. The common treatment of T1DM with strict glycemic control through intensive insulin therapy can be problematic (weight gain, insulin resistance, hypoglycemia). Regular exercise is known to improve cardiovascular health, yet most individuals with T1DM remain sedentary, and identify the risk of exercise-induced hypoglycemia as a significant barrier. The investigation into the use of different forms of exercise (higher intensity, resistance) for preventing exercise-induced hypoglycemia in populations with T1DM has been promising, however, little work has investigated their cardiovascular benefit or whether the risk of exercise-induced hypoglycemia changes over the course of exercise training. As such, using a novel insulin-treated rat model of T1DM the objectives of this dissertation were: (1) to determine whether the risk of hypoglycemia in response to different exercise modalities changes over the course of training in T1DM, (2) to characterize which exercise modality provides the largest amount of cardiovascular protection (as determined by recovery from an ischemia-reperfusion injury and fine-wire vascular myography), while assessing risk for exercise-induced hypoglycemia, and (3) to explore whether exercise training, when paired with modest glycemic control, results in larger cardiovascular protection than stringent glycemic control alone. The main findings of these collective studies were as follows; (1) the magnitude of the abrupt decline in blood glucose in response to different exercise modalities remains consistent after exercise training and infrequently reaches hypoglycemic concentrations if blood glucose concentrations are elevated prior to exercise in T1DM rats, (2) both exercise-induced fluctuations in blood glucose and the amount of cardiovascular protection obtained from regular exercise training appears to be modality-specific; however, results suggest that high intensity aerobic exercise provides the largest amount of cardiovascular protection (increased recovery from ischemia-reperfusion injury, vascular insulin sensitivity, and glycemic control), and (3) maintaining more modest glycemic control may provide similar cardiovascular benefits as stricter glycemic control when combined with regular exercise. Overall, less of a reliance on strict glycemic could allow for exercise to be performed safely (and providing cardiovascular benefits), while preventing complications associated with intensive insulin therapy.

Subjects/Keywords: diabetes; exercise training; hypoglycaemia; insulin sensitivity; cardiovascular disease; Exercise Physiology

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APA (6^th Edition):

McDonald, M. W. (2016). The Cardiovascular Benefits of Regular Exercise in Type 1 Diabetes Mellitus and the Risk of Exercise-induced Hypoglycemia. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/3943

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McDonald, Matthew W. “The Cardiovascular Benefits of Regular Exercise in Type 1 Diabetes Mellitus and the Risk of Exercise-induced Hypoglycemia.” 2016. Thesis, University of Western Ontario. Accessed March 02, 2021. https://ir.lib.uwo.ca/etd/3943.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McDonald, Matthew W. “The Cardiovascular Benefits of Regular Exercise in Type 1 Diabetes Mellitus and the Risk of Exercise-induced Hypoglycemia.” 2016. Web. 02 Mar 2021.

Vancouver:

McDonald MW. The Cardiovascular Benefits of Regular Exercise in Type 1 Diabetes Mellitus and the Risk of Exercise-induced Hypoglycemia. [Internet] [Thesis]. University of Western Ontario; 2016. [cited 2021 Mar 02]. Available from: https://ir.lib.uwo.ca/etd/3943.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McDonald MW. The Cardiovascular Benefits of Regular Exercise in Type 1 Diabetes Mellitus and the Risk of Exercise-induced Hypoglycemia. [Thesis]. University of Western Ontario; 2016. Available from: https://ir.lib.uwo.ca/etd/3943

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

26. Koushanpour, Esmail. Fourier analysis of the time curves of the basic cardiac parameters of acutely prepared open-chest cats and turtles under various experimental conditions.

Degree: PhD, 1963, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:34952

Subjects/Keywords: Cardiovascular system – Research; Physiology – Research

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koushanpour, E. (1963). Fourier analysis of the time curves of the basic cardiac parameters of acutely prepared open-chest cats and turtles under various experimental conditions. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:34952

Chicago Manual of Style (16^th Edition):

Koushanpour, Esmail. “Fourier analysis of the time curves of the basic cardiac parameters of acutely prepared open-chest cats and turtles under various experimental conditions.” 1963. Doctoral Dissertation, Michigan State University. Accessed March 02, 2021. http://etd.lib.msu.edu/islandora/object/etd:34952.

MLA Handbook (7^th Edition):

Koushanpour, Esmail. “Fourier analysis of the time curves of the basic cardiac parameters of acutely prepared open-chest cats and turtles under various experimental conditions.” 1963. Web. 02 Mar 2021.

Vancouver:

Koushanpour E. Fourier analysis of the time curves of the basic cardiac parameters of acutely prepared open-chest cats and turtles under various experimental conditions. [Internet] [Doctoral dissertation]. Michigan State University; 1963. [cited 2021 Mar 02]. Available from: http://etd.lib.msu.edu/islandora/object/etd:34952.

Council of Science Editors:

Koushanpour E. Fourier analysis of the time curves of the basic cardiac parameters of acutely prepared open-chest cats and turtles under various experimental conditions. [Doctoral Dissertation]. Michigan State University; 1963. Available from: http://etd.lib.msu.edu/islandora/object/etd:34952

Michigan State University

27. Grommet, Janet Kolmer. The effect of obesity in the rat on cardiovascular dynamics, cardiac anatomy and biochemistry, and body composition.

Degree: PhD, 1978, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:43003

Subjects/Keywords: Obesity; Cardiovascular system; Rats – Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Grommet, J. K. (1978). The effect of obesity in the rat on cardiovascular dynamics, cardiac anatomy and biochemistry, and body composition. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:43003

Chicago Manual of Style (16^th Edition):

Grommet, Janet Kolmer. “The effect of obesity in the rat on cardiovascular dynamics, cardiac anatomy and biochemistry, and body composition.” 1978. Doctoral Dissertation, Michigan State University. Accessed March 02, 2021. http://etd.lib.msu.edu/islandora/object/etd:43003.

MLA Handbook (7^th Edition):

Grommet, Janet Kolmer. “The effect of obesity in the rat on cardiovascular dynamics, cardiac anatomy and biochemistry, and body composition.” 1978. Web. 02 Mar 2021.

Vancouver:

Grommet JK. The effect of obesity in the rat on cardiovascular dynamics, cardiac anatomy and biochemistry, and body composition. [Internet] [Doctoral dissertation]. Michigan State University; 1978. [cited 2021 Mar 02]. Available from: http://etd.lib.msu.edu/islandora/object/etd:43003.

Council of Science Editors:

Grommet JK. The effect of obesity in the rat on cardiovascular dynamics, cardiac anatomy and biochemistry, and body composition. [Doctoral Dissertation]. Michigan State University; 1978. Available from: http://etd.lib.msu.edu/islandora/object/etd:43003

Arizona State University

28. Herring, Dana. Fish Oil Supplementation and Cardiovascular Disease Risk in Individuals of Blood Type A and Blood Type O.

Degree: MS, Nutrition, 2014, Arizona State University

URL: http://repository.asu.edu/items/25146

► The omega-3 fatty acids in fatty fish and fish oil, eicosapentanoic acid (EPA) and docosahexanoic acid (DHA), have been associated with a reduction in risk… (more)

Subjects/Keywords: Nutrition; Physiology; cardiovascular; dha; diabetes; epa; fish oil; omega-3

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Herring, D. (2014). Fish Oil Supplementation and Cardiovascular Disease Risk in Individuals of Blood Type A and Blood Type O. (Masters Thesis). Arizona State University. Retrieved from http://repository.asu.edu/items/25146

Chicago Manual of Style (16^th Edition):

Herring, Dana. “Fish Oil Supplementation and Cardiovascular Disease Risk in Individuals of Blood Type A and Blood Type O.” 2014. Masters Thesis, Arizona State University. Accessed March 02, 2021. http://repository.asu.edu/items/25146.

MLA Handbook (7^th Edition):

Herring, Dana. “Fish Oil Supplementation and Cardiovascular Disease Risk in Individuals of Blood Type A and Blood Type O.” 2014. Web. 02 Mar 2021.

Vancouver:

Herring D. Fish Oil Supplementation and Cardiovascular Disease Risk in Individuals of Blood Type A and Blood Type O. [Internet] [Masters thesis]. Arizona State University; 2014. [cited 2021 Mar 02]. Available from: http://repository.asu.edu/items/25146.

Council of Science Editors:

Herring D. Fish Oil Supplementation and Cardiovascular Disease Risk in Individuals of Blood Type A and Blood Type O. [Masters Thesis]. Arizona State University; 2014. Available from: http://repository.asu.edu/items/25146

University of Oregon

29. Cole, Jazmin Amber. Association between a Non-Invasive Assessment of Frailty and Vascular Dysfunction in Old Mice.

Degree: 2020, University of Oregon

URL: https://scholarsbank.uoregon.edu/xmlui/handle/1794/25733

► Advancing age is characterized by not only an increased risk for cardiovascular diseases (CVDs), but also a decline in functional reserve and impaired adaptive capacity… (more)

Subjects/Keywords: Human Physiology; Cardiovascular; Vascular Aginh; Aging; Gene Expression; Frailty

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cole, J. A. (2020). Association between a Non-Invasive Assessment of Frailty and Vascular Dysfunction in Old Mice. (Thesis). University of Oregon. Retrieved from https://scholarsbank.uoregon.edu/xmlui/handle/1794/25733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cole, Jazmin Amber. “Association between a Non-Invasive Assessment of Frailty and Vascular Dysfunction in Old Mice.” 2020. Thesis, University of Oregon. Accessed March 02, 2021. https://scholarsbank.uoregon.edu/xmlui/handle/1794/25733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cole, Jazmin Amber. “Association between a Non-Invasive Assessment of Frailty and Vascular Dysfunction in Old Mice.” 2020. Web. 02 Mar 2021.

Vancouver:

Cole JA. Association between a Non-Invasive Assessment of Frailty and Vascular Dysfunction in Old Mice. [Internet] [Thesis]. University of Oregon; 2020. [cited 2021 Mar 02]. Available from: https://scholarsbank.uoregon.edu/xmlui/handle/1794/25733.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cole JA. Association between a Non-Invasive Assessment of Frailty and Vascular Dysfunction in Old Mice. [Thesis]. University of Oregon; 2020. Available from: https://scholarsbank.uoregon.edu/xmlui/handle/1794/25733

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

30. Chung, Po-chuen, Joseph. A pharmacological study of the cardiovascular actions of 1-tetra-hydrocannabinol in rats.

Degree: 1977, University of Hong Kong

URL: http://hdl.handle.net/10722/32661

Subjects/Keywords: Rats - Physiology.; Cardiovascular agents.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chung, Po-chuen, J. (1977). A pharmacological study of the cardiovascular actions of 1-tetra-hydrocannabinol in rats. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/32661

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chung, Po-chuen, Joseph. “A pharmacological study of the cardiovascular actions of 1-tetra-hydrocannabinol in rats.” 1977. Thesis, University of Hong Kong. Accessed March 02, 2021. http://hdl.handle.net/10722/32661.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chung, Po-chuen, Joseph. “A pharmacological study of the cardiovascular actions of 1-tetra-hydrocannabinol in rats.” 1977. Web. 02 Mar 2021.

Vancouver:

Chung, Po-chuen J. A pharmacological study of the cardiovascular actions of 1-tetra-hydrocannabinol in rats. [Internet] [Thesis]. University of Hong Kong; 1977. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10722/32661.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chung, Po-chuen J. A pharmacological study of the cardiovascular actions of 1-tetra-hydrocannabinol in rats. [Thesis]. University of Hong Kong; 1977. Available from: http://hdl.handle.net/10722/32661

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations