subject:(Cardiovascular Diseases)

Michigan Technological University

1. Huber, Mike. SALT SENSITIVE HYPERTENSION AND OREXIN.

Degree: MS, Department of Biological Sciences, 2016, Michigan Technological University

URL: https://digitalcommons.mtu.edu/etdr/267

► Elevated plasma arginine vasopressin (AVP) levels have been found in human hypertension subjects and several salt dependent experimental animal models of hypertension including the… (more)

Subjects/Keywords: Cardiovascular Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Huber, M. (2016). SALT SENSITIVE HYPERTENSION AND OREXIN. (Masters Thesis). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/267

Chicago Manual of Style (16^th Edition):

Huber, Mike. “SALT SENSITIVE HYPERTENSION AND OREXIN.” 2016. Masters Thesis, Michigan Technological University. Accessed January 19, 2021. https://digitalcommons.mtu.edu/etdr/267.

MLA Handbook (7^th Edition):

Huber, Mike. “SALT SENSITIVE HYPERTENSION AND OREXIN.” 2016. Web. 19 Jan 2021.

Vancouver:

Huber M. SALT SENSITIVE HYPERTENSION AND OREXIN. [Internet] [Masters thesis]. Michigan Technological University; 2016. [cited 2021 Jan 19]. Available from: https://digitalcommons.mtu.edu/etdr/267.

Council of Science Editors:

Huber M. SALT SENSITIVE HYPERTENSION AND OREXIN. [Masters Thesis]. Michigan Technological University; 2016. Available from: https://digitalcommons.mtu.edu/etdr/267

2. Duff, Jed. Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap.

Degree: PhD, 2013, Australian Catholic University

URL: https://researchbank.acu.edu.au/theses/448

► Venous thromboembolism (VTE) is the umbrella term covering deep vein thrombosis, pulmonary embolism and a group of associated chronic conditions. This vascular disease process… (more)

Subjects/Keywords: Cardiovascular Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Duff, J. (2013). Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap. (Doctoral Dissertation). Australian Catholic University. Retrieved from https://researchbank.acu.edu.au/theses/448

Chicago Manual of Style (16^th Edition):

Duff, Jed. “Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap.” 2013. Doctoral Dissertation, Australian Catholic University. Accessed January 19, 2021. https://researchbank.acu.edu.au/theses/448.

MLA Handbook (7^th Edition):

Duff, Jed. “Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap.” 2013. Web. 19 Jan 2021.

Vancouver:

Duff J. Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap. [Internet] [Doctoral dissertation]. Australian Catholic University; 2013. [cited 2021 Jan 19]. Available from: https://researchbank.acu.edu.au/theses/448.

Council of Science Editors:

Duff J. Preventing venous thromboembolism in hospitalised patients: Using implementation science to close the evidence-practice gap. [Doctoral Dissertation]. Australian Catholic University; 2013. Available from: https://researchbank.acu.edu.au/theses/448

University of Central Florida

3. Horton, Julie. Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure.

Degree: 2017, University of Central Florida

URL: https://stars.library.ucf.edu/etd/5697

► Cardiovascular disease is currently the foremost cause of death within the United States. Heart failure (HF) is a syndrome defined by the inability of the… (more)

▼ Cardiovascular disease is currently the foremost cause of death within the United States. Heart failure (HF) is a syndrome defined by the inability of the heart to adequately execute requisite pump function in order to deliver nutrients and oxygen to peripheral tissues, irrespective of etiology. One of the most common causes of HF is chronic pressure overload due to hypertension. Ischemic heart disease is also a common driver of HF, often in conjunction with hypertension. Pressure overload initially causes compensatory metabolic changes. Structural changes follow shortly thereafter typically resulting in left ventricular hypertrophy. Eventually, the heart loses the ability to compensate for the aberrant hemodynamic load and begins failing. The failing heart is unable to supply adequate adenosine triphosphate (ATP) for contractile function as evidenced by falling phosphocreatine (PCr) levels. This energy deficit occurs concurrently with a metabolic re-programming that results in a fuel utilization pattern resembling the fetal heart. Notably, enzymes involved in catabolism of fatty acids, the chief fuel substrate for ATP generation in the normal adult heart, are downregulated in the failing heart. However, the extent to which alternative fuels compensate for decreased fatty acid oxidation (FAO) is not well-known. Furthermore, consequences of the fuel substrate switches that occur in heart failure are not well established. In this work, we discover a new paradigm for alternate fuel utilization in the failing heart and define consequences of altered fuel metabolism in HF. We discovered a post-translational modification resultant from an accumulation of acetyl groups (C2) present in a mouse model of early-stage HF and human HF. Mitochondrial proteins were found to be hyperacetylated in the failing heart, and at least some of these alterations result in diminished electron-transport chain (ETC) capacity as shown by mutagenesis studies on succinate dehydrogenase A (SDHA). We also found an accumulation of C4-OH carnitine, a by-product of ketone oxidation in HF. This metabolite aggregation occurred alongside an increase in b-hydroxybutyrate dehydrogenase 1 (BDH1) transcript and protein levels. This signature suggested that the failing heart shifted to ketone bodies as a fuel. Subsequent experiments confirmed increased capacity for myocardial ketone oxidation in compensated cardiac hypertrophy and in HF. The consequences of increased ketone oxidation were then assessed using a cardiac-specific BDH1 knockout (BDH1 KO) mouse. Despite not having any apparent defect at baseline, we found BDH1 KO mouse hearts are completely unable to oxidize 3-hydroxybutyrate. The deficit for ketone oxidation capacity became consequential upon subjugation to transverse aortic constriction with a small apical myocardial infarction (TAC/MI). The BDH1 KO mice exhibit altered pathological cardiac remodeling compared to wild-type controls. These latter data suggest the increased reliance on ketone oxidation in HF, mediated by BDH1, is an adaptive… Advisors/Committee Members: Estevez, Alvaro.

Subjects/Keywords: Cardiovascular Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Horton, J. (2017). Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure. (Doctoral Dissertation). University of Central Florida. Retrieved from https://stars.library.ucf.edu/etd/5697

Chicago Manual of Style (16^th Edition):

Horton, Julie. “Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure.” 2017. Doctoral Dissertation, University of Central Florida. Accessed January 19, 2021. https://stars.library.ucf.edu/etd/5697.

MLA Handbook (7^th Edition):

Horton, Julie. “Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure.” 2017. Web. 19 Jan 2021.

Vancouver:

Horton J. Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure. [Internet] [Doctoral dissertation]. University of Central Florida; 2017. [cited 2021 Jan 19]. Available from: https://stars.library.ucf.edu/etd/5697.

Council of Science Editors:

Horton J. Consequences of Altered Short-Chain Carbon Metabolism in Heart Failure. [Doctoral Dissertation]. University of Central Florida; 2017. Available from: https://stars.library.ucf.edu/etd/5697

4. Sager, Lauren Anne. Mindfulness and Cognitive Functioning: Mechanisms and Impacts.

Degree: School of Public Health, 2017, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:733497/

► Cognitive-Related Targets Engaged by Mindfulness-Based Interventions: A Systematic Review and Evidence Map Context: Scientific research on the effects of mindfulness has increased drastically in the… (more)

▼ Cognitive-Related Targets Engaged by Mindfulness-Based Interventions: A Systematic Review and Evidence Map Context: Scientific research on the effects of mindfulness has increased drastically in the last two decades, and many of the findings demonstrate that mindfulness can improve health conditions such as anxiety, depression, hypertension, and pain. However, the mechanisms that mindfulness engages to improve these conditions remains unclear. It has been hypothesized that improvements in cognition through mindfulness may lead to improvements in other health outcomes. However, this hypothesis remains uncertain, and the ways in which improvements in cognition through mindfulness practice are studied and measured is not thoroughly examined. Objectives: The objective of this systematic review is to first assess the assays that have been used in randomized controlled trials of mindfulness-based interventions to measure changes in cognition following mindfulness practice. The second objective is to provide a description of the state of the evidence that supports mindfulness being effective for improving cognition. Methods: A systematic review was performed. Search terms relevant to mindfulness and cognitive processes were compiled and a search as conducted in four databases. Captured studies were screened for inclusion and exclusion criteria, and those that meet all inclusion criteria and contain measures of cognitive processes are included in the systematic review. Results: The initial search captured 10,595 citations. Eight citations met all inclusion criteria and reported at least one cognition assay and are included in this review. Within the eight citations, 45 assays of cognition were reported. Conclusions: The results of this systematic review demonstrate the need for an expansion in the number and types of studies in the field focused specifically on cognitive domains of self- regulation. While preliminary evidence suggests that mindfulness may be an effective means of improving cognition, further study is necessary to confirm the notion that mindfulness practice can help improve cognition. Effects of Mindfulness-Based Blood Pressure Reduction on Dispositional Mindfulness, Attention Control, and Blood Pressure Context: Research on the effects of mindfulness has grown in recent years, and preliminary evidence suggests that mindfulness-based interventions may have positive impacts on various health outcomes. Objectives: The primary aim of this study is to assess the effects of an 8-week Mindfulness-Based Blood Pressure Reduction study on dispositional mindfulness, attention regulation, and blood pressure. Further objectives are to evaluate whether mindfulness and attention regulation are mechanisms through which Mindfulness-Based Pressure Reduction influences blood pressure. Methods: Data were collected from participants (n=43) from the Mindfulness-Based Blood Pressure Reduction program at baseline and 10 weeks follow-up. All participants had either hypertension or prehypertension (systolic/diastolic blood pressure… Advisors/Committee Members: Loucks , Eric (Advisor), Britton, Willoughby (Reader).

Subjects/Keywords: Cardiovascular system – Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sager, L. A. (2017). Mindfulness and Cognitive Functioning: Mechanisms and Impacts. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733497/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sager, Lauren Anne. “Mindfulness and Cognitive Functioning: Mechanisms and Impacts.” 2017. Thesis, Brown University. Accessed January 19, 2021. https://repository.library.brown.edu/studio/item/bdr:733497/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sager, Lauren Anne. “Mindfulness and Cognitive Functioning: Mechanisms and Impacts.” 2017. Web. 19 Jan 2021.

Vancouver:

Sager LA. Mindfulness and Cognitive Functioning: Mechanisms and Impacts. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Jan 19]. Available from: https://repository.library.brown.edu/studio/item/bdr:733497/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sager LA. Mindfulness and Cognitive Functioning: Mechanisms and Impacts. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733497/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

5. Mascall, Keith S. Sphingolipids and angiogenesis : role in cardiovascular disease.

Degree: PhD, 2012, University of Aberdeen

URL: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152996660005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560885

► Following myocardial infarction, as a result of thrombus formation, angiogenesis occurs and permits reperfusion of damaged myocardium. Sphingolipids, sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are… (more)

Subjects/Keywords: 610; Cardiovascular diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mascall, K. S. (2012). Sphingolipids and angiogenesis : role in cardiovascular disease. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152996660005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560885

Chicago Manual of Style (16^th Edition):

Mascall, Keith S. “Sphingolipids and angiogenesis : role in cardiovascular disease.” 2012. Doctoral Dissertation, University of Aberdeen. Accessed January 19, 2021. https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152996660005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560885.

MLA Handbook (7^th Edition):

Mascall, Keith S. “Sphingolipids and angiogenesis : role in cardiovascular disease.” 2012. Web. 19 Jan 2021.

Vancouver:

Mascall KS. Sphingolipids and angiogenesis : role in cardiovascular disease. [Internet] [Doctoral dissertation]. University of Aberdeen; 2012. [cited 2021 Jan 19]. Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152996660005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560885.

Council of Science Editors:

Mascall KS. Sphingolipids and angiogenesis : role in cardiovascular disease. [Doctoral Dissertation]. University of Aberdeen; 2012. Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152996660005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.560885

Malmö University

6. Wallin Bengtsson, Viveca. Periodontitis, carotid calcifications and future cardiovascular diseases in older individuals .

Degree: Malmö University. Faculty of Odontology, 2019, Malmö University

URL: http://hdl.handle.net/2043/30341

► Background. Periodontitis is a chronic inflammatory disease with a microbiological etiology affecting the supporting tissues of the tooth. The disease affects approximately 50% of the… (more)

▼ Background. Periodontitis is a chronic inflammatory disease with a microbiological etiology affecting the supporting tissues of the tooth. The disease affects approximately 50% of the adult population. The prevalence of periodontitis increases with age. The complex bacterial infection, as well as an exaggerated host inflammatory reaction, may trigger subclinical atherosclerosis. Aims. The overall aim of the present thesis was to study the associations between periodontitis, cardiovascular diseases and mortality. The specific aims were: I) to evaluate the use and value of panoramic radiographs in assessing carotid calcifications in relation to other used methods (gold standards) and to assess the literature on carotid calcifications defined from panoramic radiographs and concurrent diagnosis of stroke and periodontitis, II) to evaluate if periodontitis is associated with the presence of carotid arterial calcifications diagnosed on panoramic radiographs in an elderly population, III) to assess if carotid calcifications detected on panoramic radiographs are associated with future events of stroke, and/or ischemic heart diseases over 10–13 years in individuals between 60 and 96 years, IV) to assess if individuals ≥ 60 years of age with periodontitis are more likely to develop stroke or ischemic heart diseases or are at higher risk of death over a period of 17 years. Methods: A literature review based on peer-reviewed studies was performed evaluating the use of panoramic radiographs in assessing carotid calcifications compared to other methods. In study II, III, IV older individuals, 60 years and older participating in the Swedish National Study of Aging and Care (SNAC) were included in the studies. A dental hygienist performed a dental clinical and radiographic examination. Probing depths (PD) and bleeding on probing (BOP) was registered. From radiographic panoramic images, the distances between the alveolar bone level and the cement enamel junction (CEJ) were measured. In study II, a diagnosis of periodontitis was declared, using a composite definition; if a distance between the alveolar bone level and the CEJ ≥5 mm on panoramic radiographs at >10% of sites and PD ≥5 mm at one or more teeth and with BOP >20% of teeth. In study IV, an indicator of a history of periodontal disease was declared if a distance between the alveolar bone level and the CEJ ≥5 mm on panoramic radiographs at ≥30% of sites. Evidence of a radiopaque nodular mass in the intervertebral space at or below the vertebrae C3-C4 was identified as carotid calcification. In addition, a medical research team performed the medical examinations, and a medical doctor (JB) reviewed all medical records for information about events of stroke and ischemic heart diseases. Stroke and ischemic heart diseases were registered according to the ICD 10 codes: ICD 60-69 for stroke and ICD: 20-25 for ischemic heart diseases. Study I was a review of the literature, in study II, a cross-sectional study design was employed. In studies…

Subjects/Keywords: Parodontit; Cardiovascular Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wallin Bengtsson, V. (2019). Periodontitis, carotid calcifications and future cardiovascular diseases in older individuals . (Thesis). Malmö University. Retrieved from http://hdl.handle.net/2043/30341

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wallin Bengtsson, Viveca. “Periodontitis, carotid calcifications and future cardiovascular diseases in older individuals .” 2019. Thesis, Malmö University. Accessed January 19, 2021. http://hdl.handle.net/2043/30341.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wallin Bengtsson, Viveca. “Periodontitis, carotid calcifications and future cardiovascular diseases in older individuals .” 2019. Web. 19 Jan 2021.

Vancouver:

Wallin Bengtsson V. Periodontitis, carotid calcifications and future cardiovascular diseases in older individuals . [Internet] [Thesis]. Malmö University; 2019. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2043/30341.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wallin Bengtsson V. Periodontitis, carotid calcifications and future cardiovascular diseases in older individuals . [Thesis]. Malmö University; 2019. Available from: http://hdl.handle.net/2043/30341

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

7. DiStefano, Kristin, 1995-. Software derived brachial artery function.

Degree: MS, Biomedical Engineering, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/57538/

► Endothelial dysfunction has been proven to be an early indication of cardiovascular disease (CVD), a leading cause of death worldwide (Sorsen 1995; WHO 2017). There… (more)

▼ Endothelial dysfunction has been proven to be an early indication of cardiovascular disease (CVD), a leading cause of death worldwide (Sorsen 1995; WHO 2017). There are three diagnostic methods for endothelial functions discussed: ultrasound Flow-Mediated Dilation (uFMD) that uses ultrasound to determine brachial artery size, Peripheral Arterial Tonometry (PAT) that uses finger pulse plethysmographs, and Cuff Flow-Mediated Dilation (cFMD) that uses pressure oscillations in a blood pressure cuff. Each of the three methods first collect a control or “resting” measurement before obtaining a vasodilation measurement of the blood vessels by occluding blood flow for 5-minutes with a blood pressure cuff. Output for uFMD and PAT testing results in a singular number, percent dilation (FMD%) and reactive hyperemia index (RHI) respectively, based on the blood vessel’s percent dilation (Sorsen 1995; Allan 2013; Whitt 2010). Each method has multiple factors that influence results such as body mass index, coronary artery disease, peripheral artery disease and a patient’s height (Van der Heijden 2017; Allan 2013; Schroeder 2000). It is proposed that a mathematical model used with cFMD can generate a smooth continuous output for analysis and help understand the effect that transmural pressure has on vessel dilation. In this thesis, a biomechanical model of the human brachial artery was programmed to represent both the resting and vasodilated conditions of the brachial artery. Data for the resting and vasodilated states of six subjects were collected using cFMD. First, the patient’s blood pressure and heart rate were observed. Next, the resting curve was obtained before a 5-minute occlusion. Lastly, the vasodilated measurements were taken. For each of the 6 subjects, the model was found to accurately represent the data collected for the resting and vasodilated states. Using the model, transmural pressure was found to influence the vessel’s percent dilation curve. Combining the model with cFMD allows for FMD to be performed without ultrasound, generates a larger SNR, and allows for analysis of percent dilation at multiple values of transmural pressure. The accuracy of the automated model has potential to generate other graphs to understand the artery’s compliance and the effects of physiological functions such as the pulse. Further research should be done to determine what transmural pressure value would be optimal in minimizing the factors that influence test results. Advisors/Committee Members: Drzewiecki, Gary (chair), Pierce, Mark (internal member), Berthiaume, Francois (internal member), School of Graduate Studies.

Subjects/Keywords: Cardiovascular system – Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

DiStefano, Kristin, 1. (2018). Software derived brachial artery function. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/57538/

Chicago Manual of Style (16^th Edition):

DiStefano, Kristin, 1995-. “Software derived brachial artery function.” 2018. Masters Thesis, Rutgers University. Accessed January 19, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/57538/.

MLA Handbook (7^th Edition):

DiStefano, Kristin, 1995-. “Software derived brachial artery function.” 2018. Web. 19 Jan 2021.

Vancouver:

DiStefano, Kristin 1. Software derived brachial artery function. [Internet] [Masters thesis]. Rutgers University; 2018. [cited 2021 Jan 19]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57538/.

Council of Science Editors:

DiStefano, Kristin 1. Software derived brachial artery function. [Masters Thesis]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57538/

8. Wei, Bai. Effects of APOA1/C3/A4/A5 Gene Cluster and Flavonoids Intake on Cardiovascular Disease Risk Factors in U.S. Populations.

Degree: PhD, Health and Nutritional Sciences, 2013, South Dakota State University

URL: https://openprairie.sdstate.edu/etd/1371

► The overall objective of this study is to investigate the consumption of flavonoids, the prevalence of APOA1/C3/A4/A5 gene cluster, the interaction between these genes… (more)

▼ The overall objective of this study is to investigate the consumption of flavonoids, the prevalence of APOA1/C3/A4/A5 gene cluster, the interaction between these genes and flavonoids intake on how they impact cardiovascular disease (CVD) risks among U.S. adults. We focused on four aims: (1) to estimate the dietary flavonoids intake among U.S. adults; (2) to determine the effects of flavonoids consumption on blood lipids among U.S. adults; (3) to investigate the effect of APOA1/C3/A4/A5 gene cluster on blood lipids among U.S. adults; (4) to study the effect of APOA1/C3/A4/A5 gene cluster on the risks of CVDs and the interaction between these genes and flavonoids consumption. We used data from NHANES III to fulfill our aims. We calculated individual, subclasses and total flavonoid intakes. We received special permission from CDC and remotely accessed their genetic database for our data analysis. We studied the prevalence of APOA1/C3/A4/A5 gene cluster among U.S. adults. We did descriptive and regression analyses to determine the associations between flavonoids and lipids, genes and lipids, genes and CVDs and interactions between flavonoids consumption and genes on the risks of CVD. The study showed that estimated mean total flavonoid intake by U.S. adults was 305.3±17.5 mg/day. The flavan-3-ols (247±16.9mg/day) were the most abundant flavonoid class followed by flavanones (25.9±1.1mg/day), flavonols (19.6±0.9mg/day), anthocyanidins (9.5±0.6mg/day), isoflavones (2.4±0.1mg/day), and flavones (1.0±0.0mg/day). The three most dominant individual flavonoids were catechin (167.5±6.1mg/day), epicatechin (68.5±2.3mg/day) and hesperetin (19.1±1.0mg/day). People with high alcohol consumption, low educational level, low-income level, and smokers tended to consume less flavonoids. Tea (32.7%), beers (22.7%), wines (9.8%), banana (9.7%) and citrus fruits (6.8%) were the most important sources of total flavonoid intake. Our study also clearly demonstrated the impacts of socio-demographic factors on blood lipids levels among U.S. adults and revealed that higher consumption of total flavonoids, flavan_3_ols, flavone, and flavonol led to higher high-density lipoprotein cholesterol. Our data showed that allele frequencies of these lipid associated SNPs varied significantly by race/ethnicity. Several associations between specific alleles and lipid levels among the racial/ethnic groups were discovered and they have the potential to be used in predicting CVD risks. We have discovered several associations between these alleles and CVD risks. In addition, we also explored the interactions between dietary flavonoids and select genes on CVDs. We are the first to report that flavonoids intakes might protect people with certain alleles against CVD by lowering the risk of heart attack, heart failure and stroke. Our research provides the foundation on clarifying the effects and interactions of dietary flavonoids and APOA1/C3/A4/A5 gene cluster on CVDs. Advisors/Committee Members: C.Y. Wang;.

Subjects/Keywords: Cardiovascular Diseases; Nutrition

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wei, B. (2013). Effects of APOA1/C3/A4/A5 Gene Cluster and Flavonoids Intake on Cardiovascular Disease Risk Factors in U.S. Populations. (Doctoral Dissertation). South Dakota State University. Retrieved from https://openprairie.sdstate.edu/etd/1371

Chicago Manual of Style (16^th Edition):

Wei, Bai. “Effects of APOA1/C3/A4/A5 Gene Cluster and Flavonoids Intake on Cardiovascular Disease Risk Factors in U.S. Populations.” 2013. Doctoral Dissertation, South Dakota State University. Accessed January 19, 2021. https://openprairie.sdstate.edu/etd/1371.

MLA Handbook (7^th Edition):

Wei, Bai. “Effects of APOA1/C3/A4/A5 Gene Cluster and Flavonoids Intake on Cardiovascular Disease Risk Factors in U.S. Populations.” 2013. Web. 19 Jan 2021.

Vancouver:

Wei B. Effects of APOA1/C3/A4/A5 Gene Cluster and Flavonoids Intake on Cardiovascular Disease Risk Factors in U.S. Populations. [Internet] [Doctoral dissertation]. South Dakota State University; 2013. [cited 2021 Jan 19]. Available from: https://openprairie.sdstate.edu/etd/1371.

Council of Science Editors:

Wei B. Effects of APOA1/C3/A4/A5 Gene Cluster and Flavonoids Intake on Cardiovascular Disease Risk Factors in U.S. Populations. [Doctoral Dissertation]. South Dakota State University; 2013. Available from: https://openprairie.sdstate.edu/etd/1371

University of Aberdeen

9. Ostertag, Luisa Martha. The impact of dietary polyphenols on human platelets : integrating functional and nutrigenomic analyses.

Degree: PhD, 2011, University of Aberdeen

URL: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153025240005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558602

► This thesis aims to integrate functional and nutrigenomics analyses to examine how dietary polyphenols affect human platelet function and thus may contribute to the prevention… (more)

▼ This thesis aims to integrate functional and nutrigenomics analyses to examine how dietary polyphenols affect human platelet function and thus may contribute to the prevention of cardiovascular diseases. Initially, 26 low molecular weight phenolic compounds were screened for their effects on platelet aggregation and P-selectin expression in vitro. Only high, non-physiological concentrations of some phenolics showed anti-platelet effects. In parallel we conducted a systematic review of the literature to assess how polyphenol-rich foodstuffs, beverages, or extracts affect platelet function in humans. Cocoa-derived flavan-3-ols were the only class of dietary polyphenols that consistently showed anti-platelet effects in both, acute and chronic settings. Consequently we conducted an acute randomised-controlled human intervention study in which healthy volunteers consumed three different types of chocolates containing different amounts of flavan-3-ols. We found that flavan-3-ol-enriched dark chocolate beneficially affected ex vivo bleeding time, platelet aggregation and P-selectin expression. These effects were gender-dependent. Bioavailability of cocoa-derived flavan-3-ols, as assessed by a targeted metabolomics approach, was also gender-dependent. Using a platelet proteomics approach, we found subtle changes in platelet protein levels 2 h after consumption of flavan-3-ol-enriched chocolate in men, which may partly explain the observed anti-platelet effects. Finally, we assessed whether flavan-3-ols are internalised in platelets after consumption of dark chocolate. No internalisation could be found up to 2.5 h after chocolate ingestion, despite these compounds appearing in plasma. In conclusion, flavan- 3-ol-enriched dark chocolate beneficially affects platelet function in a gender-dependent way, but underpinning mechanisms are still unknown. Furthermore, current insights into their bioavailability cannot fully explain the ability of flavan-3-ols to affect platelet function. Successful future progress of research into the bioavailability and mechanisms of flavan-3- ols in vitro and in vivo will depend on the availability of pure standards for the major human metabolites of flavan-3-ols.

Subjects/Keywords: 616.157; Cardiovascular diseases; Cardiovascular system; Cocoa

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ostertag, L. M. (2011). The impact of dietary polyphenols on human platelets : integrating functional and nutrigenomic analyses. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153025240005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558602

Chicago Manual of Style (16^th Edition):

Ostertag, Luisa Martha. “The impact of dietary polyphenols on human platelets : integrating functional and nutrigenomic analyses.” 2011. Doctoral Dissertation, University of Aberdeen. Accessed January 19, 2021. https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153025240005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558602.

MLA Handbook (7^th Edition):

Ostertag, Luisa Martha. “The impact of dietary polyphenols on human platelets : integrating functional and nutrigenomic analyses.” 2011. Web. 19 Jan 2021.

Vancouver:

Ostertag LM. The impact of dietary polyphenols on human platelets : integrating functional and nutrigenomic analyses. [Internet] [Doctoral dissertation]. University of Aberdeen; 2011. [cited 2021 Jan 19]. Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153025240005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558602.

Council of Science Editors:

Ostertag LM. The impact of dietary polyphenols on human platelets : integrating functional and nutrigenomic analyses. [Doctoral Dissertation]. University of Aberdeen; 2011. Available from: https://eu03.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153025240005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558602

Loyola University Chicago

10. Grady, Kathleen L. Predictors of Compliance with Diet and Exercise Six Months After Heart Transplantation.

Degree: PhD, Nursing, 1993, Loyola University Chicago

URL: https://ecommons.luc.edu/luc_diss/3287

Subjects/Keywords: Cardiovascular Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Grady, K. L. (1993). Predictors of Compliance with Diet and Exercise Six Months After Heart Transplantation. (Doctoral Dissertation). Loyola University Chicago. Retrieved from https://ecommons.luc.edu/luc_diss/3287

Chicago Manual of Style (16^th Edition):

Grady, Kathleen L. “Predictors of Compliance with Diet and Exercise Six Months After Heart Transplantation.” 1993. Doctoral Dissertation, Loyola University Chicago. Accessed January 19, 2021. https://ecommons.luc.edu/luc_diss/3287.

MLA Handbook (7^th Edition):

Grady, Kathleen L. “Predictors of Compliance with Diet and Exercise Six Months After Heart Transplantation.” 1993. Web. 19 Jan 2021.

Vancouver:

Grady KL. Predictors of Compliance with Diet and Exercise Six Months After Heart Transplantation. [Internet] [Doctoral dissertation]. Loyola University Chicago; 1993. [cited 2021 Jan 19]. Available from: https://ecommons.luc.edu/luc_diss/3287.

Council of Science Editors:

Grady KL. Predictors of Compliance with Diet and Exercise Six Months After Heart Transplantation. [Doctoral Dissertation]. Loyola University Chicago; 1993. Available from: https://ecommons.luc.edu/luc_diss/3287

University of Texas Southwestern Medical Center

11. Camacho, Juan Jose. State Vocational Rehabilitation Services and Employment for Individuals with Cardiac and Other Types of Circulatory System Conditions.

Degree: 2015, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/2709

► BACKGROUND: Obtaining and maintain employment can be a significant challenge for individuals with disabilities, including cardiac and other conditions of the circulatory system. Although federal… (more)

Subjects/Keywords: Cardiovascular Diseases; Employment; Rehabilitation, Vocational

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Camacho, J. J. (2015). State Vocational Rehabilitation Services and Employment for Individuals with Cardiac and Other Types of Circulatory System Conditions. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/2709

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Camacho, Juan Jose. “State Vocational Rehabilitation Services and Employment for Individuals with Cardiac and Other Types of Circulatory System Conditions.” 2015. Thesis, University of Texas Southwestern Medical Center. Accessed January 19, 2021. http://hdl.handle.net/2152.5/2709.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Camacho, Juan Jose. “State Vocational Rehabilitation Services and Employment for Individuals with Cardiac and Other Types of Circulatory System Conditions.” 2015. Web. 19 Jan 2021.

Vancouver:

Camacho JJ. State Vocational Rehabilitation Services and Employment for Individuals with Cardiac and Other Types of Circulatory System Conditions. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2015. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152.5/2709.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Camacho JJ. State Vocational Rehabilitation Services and Employment for Individuals with Cardiac and Other Types of Circulatory System Conditions. [Thesis]. University of Texas Southwestern Medical Center; 2015. Available from: http://hdl.handle.net/2152.5/2709

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Central Queensland University

12. Batt, AM. The impact of an organised system of cardiac care on patient outcomes in the Emirate of Ras al-Khaimah, United Arab Emirates.

Degree: 2017, Central Queensland University

URL: http://hdl.cqu.edu.au/10018/1254887

►

Batt, AM ORCiD: 0000-0001-6473-5397

The aim was to evaluate the evidence for pre-hospital 12-Lead electrocardiogram (ECG) acquisition, and percutaneous coronary intervention (PCI) activation and to… (more)

Subjects/Keywords: 110201 Cardiology (incl. Cardiovascular Diseases)

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Batt, A. (2017). The impact of an organised system of cardiac care on patient outcomes in the Emirate of Ras al-Khaimah, United Arab Emirates. (Thesis). Central Queensland University. Retrieved from http://hdl.cqu.edu.au/10018/1254887

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Batt, AM. “The impact of an organised system of cardiac care on patient outcomes in the Emirate of Ras al-Khaimah, United Arab Emirates.” 2017. Thesis, Central Queensland University. Accessed January 19, 2021. http://hdl.cqu.edu.au/10018/1254887.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Batt, AM. “The impact of an organised system of cardiac care on patient outcomes in the Emirate of Ras al-Khaimah, United Arab Emirates.” 2017. Web. 19 Jan 2021.

Vancouver:

Batt A. The impact of an organised system of cardiac care on patient outcomes in the Emirate of Ras al-Khaimah, United Arab Emirates. [Internet] [Thesis]. Central Queensland University; 2017. [cited 2021 Jan 19]. Available from: http://hdl.cqu.edu.au/10018/1254887.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Batt A. The impact of an organised system of cardiac care on patient outcomes in the Emirate of Ras al-Khaimah, United Arab Emirates. [Thesis]. Central Queensland University; 2017. Available from: http://hdl.cqu.edu.au/10018/1254887

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Catholique de Louvain

13. Vanhoutte, Laetitia. Ultra high field MRI for the characterization of murine models of cardiovascular diseases.

Degree: 2018, Université Catholique de Louvain

URL: http://hdl.handle.net/2078.1/195312

►

With the advent of transgenic and gene knockout technologies, rodents have become a cornerstone of cardiovascular research. However, accurate in vivo cardiac characterization of small… (more)

Subjects/Keywords: Mice; MRI; Cardiomyopathy; Cardiovascular diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vanhoutte, L. (2018). Ultra high field MRI for the characterization of murine models of cardiovascular diseases. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/195312

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vanhoutte, Laetitia. “Ultra high field MRI for the characterization of murine models of cardiovascular diseases.” 2018. Thesis, Université Catholique de Louvain. Accessed January 19, 2021. http://hdl.handle.net/2078.1/195312.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vanhoutte, Laetitia. “Ultra high field MRI for the characterization of murine models of cardiovascular diseases.” 2018. Web. 19 Jan 2021.

Vancouver:

Vanhoutte L. Ultra high field MRI for the characterization of murine models of cardiovascular diseases. [Internet] [Thesis]. Université Catholique de Louvain; 2018. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2078.1/195312.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vanhoutte L. Ultra high field MRI for the characterization of murine models of cardiovascular diseases. [Thesis]. Université Catholique de Louvain; 2018. Available from: http://hdl.handle.net/2078.1/195312

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Nevada – Las Vegas

14. Shaheen, Hanaa Adnan. The Acute Effect of Endurance Exercise on Lipoproteins Measured by Nuclear Magnetic Resonance (NMR) in Healthy Men.

Degree: MS, Kinesiology and Nutrition Sciences, 2012, University of Nevada – Las Vegas

URL: https://digitalscholarship.unlv.edu/thesesdissertations/1626

► Background: Cardiovascular disease (CVD) represents a major cause of death in the United States, with abnormal levels of blood lipids and physical inactivity considered… (more)

▼ Background: Cardiovascular disease (CVD) represents a major cause of death in the United States, with abnormal levels of blood lipids and physical inactivity considered as major modifiable risk factors. The conventional lipid profile has been used to assess for CVD risk by directly measuring the concentrations of blood lipids. However, lipoprotein particle size and number obtained from a novel method, Nuclear Magnetic Resonance (NMR) may also asses for CVD risk with greater sensitivity. Exercise and increased physical activity has been shown to produce favorable effects on blood lipids and consequently reduce CVD risk. To understand this effect, it is important to understand the acute effects of an exercise session on these parameters. Purpose: The purpose of this study was to examine the effect of a 60-minute bout of dynamic exercise on lipoprotein particle number and size as measured by NMR, and compare it to the conventional lipid profile analysis. Method: Eight active healthy men between the ages of 19-34 years (age= 26 ± 5.17) participated in the study. After assessment of body composition and aerobic fitness, participants ran for 60 minutes at 70% of their aerobic fitness on a motor driven treadmill. Fasting blood samples were drawn immediately before, 5 minutes and 24 hours after exercise. Samples were sent to LipoScience, Inc. for the analysis of the lipoproteins by the NMR method and to Quest Diagnostics for the conventional lipid profile analysis. Results: The conventional profile showed a significant change in triglycerides (TG), (p=.019) immediately after exercise with a significant increase of 22%, then a non significant decrease of 13% from baseline after 24 hours. The NMR profile showed a significant change in the large HDL particle concentration (p=.046) with an increase of 5.8% observed immediately after exercise, and a decrease of 6.7% observed 24 hours after exercise. However, none of these changes were significantly different from the baseline value. Both profiles did not show any significant changes in any of the other parameters. Conclusion: Changes were observed in blood lipids that might be attributed to the session of exercise. The conventional profile has detected a significant change in HDL-C and TG. However, these changes were not significant from baseline. Also, the NMR profile detected changes in the HDL particles through large HDL particle concentration and this change in large HDL particle concentration was not significant from baseline either. So, the NMR profile was not more sensitive in detecting acute exercise-induced changes on blood lipids, in terms of CVD risk. Advisors/Committee Members: Antonio Santo, John Young, Richard Tandy, Patricia Alpert.

Subjects/Keywords: Cardiovascular Diseases; Exercise Science; Kinesiology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shaheen, H. A. (2012). The Acute Effect of Endurance Exercise on Lipoproteins Measured by Nuclear Magnetic Resonance (NMR) in Healthy Men. (Masters Thesis). University of Nevada – Las Vegas. Retrieved from https://digitalscholarship.unlv.edu/thesesdissertations/1626

Chicago Manual of Style (16^th Edition):

Shaheen, Hanaa Adnan. “The Acute Effect of Endurance Exercise on Lipoproteins Measured by Nuclear Magnetic Resonance (NMR) in Healthy Men.” 2012. Masters Thesis, University of Nevada – Las Vegas. Accessed January 19, 2021. https://digitalscholarship.unlv.edu/thesesdissertations/1626.

MLA Handbook (7^th Edition):

Shaheen, Hanaa Adnan. “The Acute Effect of Endurance Exercise on Lipoproteins Measured by Nuclear Magnetic Resonance (NMR) in Healthy Men.” 2012. Web. 19 Jan 2021.

Vancouver:

Shaheen HA. The Acute Effect of Endurance Exercise on Lipoproteins Measured by Nuclear Magnetic Resonance (NMR) in Healthy Men. [Internet] [Masters thesis]. University of Nevada – Las Vegas; 2012. [cited 2021 Jan 19]. Available from: https://digitalscholarship.unlv.edu/thesesdissertations/1626.

Council of Science Editors:

Shaheen HA. The Acute Effect of Endurance Exercise on Lipoproteins Measured by Nuclear Magnetic Resonance (NMR) in Healthy Men. [Masters Thesis]. University of Nevada – Las Vegas; 2012. Available from: https://digitalscholarship.unlv.edu/thesesdissertations/1626

Erasmus University Rotterdam

15. S.M. Willems (Sara). From Gene Discovery to Understanding and Predicting Cardiometabolic Disease.

Degree: 2014, Erasmus University Rotterdam

URL: http://hdl.handle.net/1765/77479

► __Abstract__ Cardiovascular diseases (CVD) are the leading cause of morbidity and the number one cause of death worldwide.1 An estimated 17.3 million people died from… (more)

Subjects/Keywords: cardiovascular diseases; metabolic syndrom

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

(Sara), S. W. (2014). From Gene Discovery to Understanding and Predicting Cardiometabolic Disease. (Thesis). Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/77479

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

(Sara), S.M. Willems. “From Gene Discovery to Understanding and Predicting Cardiometabolic Disease.” 2014. Thesis, Erasmus University Rotterdam. Accessed January 19, 2021. http://hdl.handle.net/1765/77479.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

(Sara), S.M. Willems. “From Gene Discovery to Understanding and Predicting Cardiometabolic Disease.” 2014. Web. 19 Jan 2021.

Vancouver:

(Sara) SW. From Gene Discovery to Understanding and Predicting Cardiometabolic Disease. [Internet] [Thesis]. Erasmus University Rotterdam; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/1765/77479.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

(Sara) SW. From Gene Discovery to Understanding and Predicting Cardiometabolic Disease. [Thesis]. Erasmus University Rotterdam; 2014. Available from: http://hdl.handle.net/1765/77479

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

16. Mascall, Keith S. Sphingolipids and angiogenesis.

Degree: School of Medical Sciences., 2012, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=189442 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=189442&custom_att_2=simple_viewer

Subjects/Keywords: Cardiovascular diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mascall, K. S. (2012). Sphingolipids and angiogenesis. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=189442 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=189442&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Mascall, Keith S. “Sphingolipids and angiogenesis.” 2012. Doctoral Dissertation, University of Aberdeen. Accessed January 19, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=189442 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=189442&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Mascall, Keith S. “Sphingolipids and angiogenesis.” 2012. Web. 19 Jan 2021.

Vancouver:

Mascall KS. Sphingolipids and angiogenesis. [Internet] [Doctoral dissertation]. University of Aberdeen; 2012. [cited 2021 Jan 19]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=189442 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=189442&custom_att_2=simple_viewer.

Council of Science Editors:

Mascall KS. Sphingolipids and angiogenesis. [Doctoral Dissertation]. University of Aberdeen; 2012. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=189442 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=189442&custom_att_2=simple_viewer

University of Limerick

17. Redfern, Shane. The effects of sous-vide cooking on the bio-functionality, nutritional value and health benefits of salmon lipids.

Degree: 2019, University of Limerick

URL: http://hdl.handle.net/10344/8497

►

peer-reviewed

Cardiovascular diseases has become the major cause of death globally. Inflammation and platelet aggregation play crucial role in the development and progression of atherosclerosis… (more)

▼

peer-reviewed

Cardiovascular diseases has become the major cause of death globally. Inflammation and platelet aggregation play crucial role in the development and progression of atherosclerosis and CVD. prevent inflammation, atherosclerosis, and endothelial dysfunction and ultimately cardiovascular events. Fish and especially oily fish such as Salmon are vital components of healthy dietary patterns with preventive properties against CVD. Raw salmon contain bioactive polar lipids (PLs) with strong antithrombotic bioactivities. However, salmon is mainly consumed cooked. The aim of the present study was to evaluate for the first time the effects of the emerging mild sous vide cooking processing on the antithrombotic properties, lipid content and sensory characteristics of salmon. Total lipids (TLs) were extracted from brined and un-brined salmon sous vide preparations in several temperatures (52°C, 65°C and 80°C) and further separated into the Neutral Lipids (NLs) and PLs fractions. The antithrombotic properties of salmon PLs were tested in human platelets, while their fatty acid content was determined by LC-MS analysis. Sensory tests were performed using napping followed by check-all-that apply. Sous vide salmon preparations in all conditions did not affect the taste, whereas in 65°C and 80°C slight textural differences were observed. Mild sous vide cooking of brined or un-brined salmon in low temperatures (52-65°C) did not affect the potent inhibitory effect of salmon PLs against human platelet aggregation induced by the inflammatory and thrombotic mediators’ platelet-activating factor (PAF) and thrombin, but also by the well-established platelet agonists adenosine diphosphate (ADP) and collagen. Sous vide preparations of both brined and un-brined salmon in higher temperatures, such as those usually applied for pasteurization (80°C), resulted in reduction of these antithrombotic properties of salmon. This was accompanied by a reduction of the EPA and DHA content of the salmon in these conditions in the un-brined sous vide preparations. Nevertheless, the antithrombotic properties of salmon PLs were preserved in considerable potency even when high temperatures were applied for the sous vide salmon preparations. This outcome if combined with the observed low values of the n-6/n-3 ratio of the PUFA content in the salmon PLs of all sous vide preparations, further suggest a beneficial role for such a mild cooking procedure for preserving the cardio-protective properties of salmon.

Advisors/Committee Members: Zabetakis, Ioannis, EI.

Subjects/Keywords: cardiovascular diseases; atheroscelerosis; CVD; salmon

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Redfern, S. (2019). The effects of sous-vide cooking on the bio-functionality, nutritional value and health benefits of salmon lipids. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/8497

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Redfern, Shane. “The effects of sous-vide cooking on the bio-functionality, nutritional value and health benefits of salmon lipids.” 2019. Thesis, University of Limerick. Accessed January 19, 2021. http://hdl.handle.net/10344/8497.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Redfern, Shane. “The effects of sous-vide cooking on the bio-functionality, nutritional value and health benefits of salmon lipids.” 2019. Web. 19 Jan 2021.

Vancouver:

Redfern S. The effects of sous-vide cooking on the bio-functionality, nutritional value and health benefits of salmon lipids. [Internet] [Thesis]. University of Limerick; 2019. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10344/8497.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Redfern S. The effects of sous-vide cooking on the bio-functionality, nutritional value and health benefits of salmon lipids. [Thesis]. University of Limerick; 2019. Available from: http://hdl.handle.net/10344/8497

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

18. Razavi, Marianne, 1970-. Statistical analysis and modeling of the agreement between the Intrinsic Frequencies technique and the established cardiovascular monitoring methods.

Degree: PhD, Biomedical Informatics, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/49759/

►

There is an urgent need for a new cardiovascular monitoring technology in order to address the limitations of the traditional devices currently in use and… (more)

▼

There is an urgent need for a new cardiovascular monitoring technology in order to address the limitations of the traditional devices currently in use and to curb the epidemic of heart diseases. This study was designed to evaluate Intrinsic Frequencies (IFs), a novel and non-invasive cardiovascular assessment approach with the potential of rendering the monitoring process more practical and cost effective. IFs indices are extracted from the “shape” of the arterial pressure waveform via a modified sparse time-frequency method, designed for analyzing signals. Throughout this study, the performance of the IFs technique for the assessment of Left Ventricular Ejection Fraction (LVEF), Cardiac Output (CO) and Pulse Wave Velocity (PWV) was examined. The results generated by the IFs method were compared to the measurements produced by the established monitoring devices. Observational studies were conducted and through the application of supervised machine learning, numerous statistical models were produced which, displayed the relationships between the IFs technique and the traditional methods, for the evaluation of cardiovascular parameters. Multiple regression analysis was applied in order to “train” the models. The selected models were subsequently “tested” for their accuracy and precision. The limits of agreement between the IFs method and the established techniques were assessed via Bland Altman approach. There was an overall strong relationship between the IFs technique and the standard monitoring methods for the assessment of LVEF, CO and PWV. The correlation between LVEF_IFs (Model 2-iPhone) and LVEF_MRI was strong (r=0.79, p<0.0001) and Bland Altman analysis showed a reasonable clinical agreement between the two methods, with a mean bias of 1.76% and unbiased limits of agreement (LA) of +/- 17.44%. Regarding CO estimates, IFs (Model 4) was fitted on the training set only, since an appropriate testing set was unavailable at the time of the study. The results were satisfactory. The CO study revealed a significant correlation between IFs and MRI (R=0.68, p<0.0001) as well as an adequate agreement, with zero bias and narrow LA (+/- 1.78 L/min). Moreover, the generated percentage error (36%) was close to the clinically acceptable threshold (30%) for CO. In reference to PWV measurements, IFs (Model 7) displayed a moderately strong correlation with Tonometry (r=0.64, p<0.0001) and Bland Altman analysis showed a negligible bias of -0.022 m/s and LA of +/- 2.37m/s. The present study was the first to evaluate the performance of the IFs method with regards to the estimation of the major cardiovascular health indices. We demonstrated that there is a significant correlation and agreement between the IFs technique of assessing LVEF, CO, PWV and the established methods of cardiovascular monitoring.

Advisors/Committee Members: Haque, Syed (chair), School of Health Professions.

Subjects/Keywords: Statistics; Cardiovascular system – Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Razavi, Marianne, 1. (2016). Statistical analysis and modeling of the agreement between the Intrinsic Frequencies technique and the established cardiovascular monitoring methods. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/49759/

Chicago Manual of Style (16^th Edition):

Razavi, Marianne, 1970-. “Statistical analysis and modeling of the agreement between the Intrinsic Frequencies technique and the established cardiovascular monitoring methods.” 2016. Doctoral Dissertation, Rutgers University. Accessed January 19, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/49759/.

MLA Handbook (7^th Edition):

Razavi, Marianne, 1970-. “Statistical analysis and modeling of the agreement between the Intrinsic Frequencies technique and the established cardiovascular monitoring methods.” 2016. Web. 19 Jan 2021.

Vancouver:

Razavi, Marianne 1. Statistical analysis and modeling of the agreement between the Intrinsic Frequencies technique and the established cardiovascular monitoring methods. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Jan 19]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49759/.

Council of Science Editors:

Razavi, Marianne 1. Statistical analysis and modeling of the agreement between the Intrinsic Frequencies technique and the established cardiovascular monitoring methods. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49759/

Rutgers University

19. Shaik, Riaz Basha, 1979-. Hypercalcemia and Its effects on the cardiovascular diseases: a retrospective analysis.

Degree: PhD, Biomedical Informatics, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/49760/

►

Recent increase in health awareness has led to substantial increase in dietary Calcium intake and supplements. Americans spend more than $1 billion a year on… (more)

▼

Recent increase in health awareness has led to substantial increase in dietary Calcium intake and supplements. Americans spend more than $1 billion a year on calcium supplements in hopes of staying off Osteoporosis”. Osteoporosis has been common in elderly women and men. There is the increase need to find if increase intake of calcium is doing more harm than good. The study objective is to determine the incidence of Hypercalcemia and its relation to calcium rich diet based on gender, race, ethnicity and socioeconomic status. All patients with serum calcium ≥14 mg/dl (≥3.5 mmol/l) are considered Hypercalcemia patients. Pathological role of calcium in calcification of the arteries increase the emphasis to find if it accentuates the process with its increase in availability. In this research, we plan to do a Retrospective analysis of Hypercalcemic patients and its association with cardiovascular diseases like Hypertension, Myocardial Infarction, Coronary Artery Occlusion, Coronary artery atherosclerosis and Stroke and overall mortality. NATIONWIDE INPATIENT SAMPLE 2006 -2102 data and NHANES 2006- 2010 data used for analysis. SAS (version 9.4, SAS Institute) has been used to calculate utilization and mean of calcium intake from both diet and supplements. Tabulating it independently based on gender, race and ethnicity and socioeconomic status. Descriptive analysis and Linear regression used to determine an association of Hypercalcemia and Cardiovascular diseases, and if any increase in mortality during the Years. Non-Hispanic white used more supplemental calcium in comparison to Hispanic and African American population.28% of men and 38% of women used throughout the recent study. Study of regression analysis has to be carried out for Association of hypercalcemia and CVD. Results showed no significant association between the two and found an association with Diabetes Mellitus. The study emphasized areas that can be directed for designing health intervention plans that will be targeted to particular subgroups of the American population

Advisors/Committee Members: Syed, Haque (chair), Srinivasan, Shanker (internal member), Mittal, Dinesh (internal member), Coffman, Fredrick D (internal member), School of Health Professions.

Subjects/Keywords: Hypercalcemia; Cardiovascular system – Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shaik, Riaz Basha, 1. (2016). Hypercalcemia and Its effects on the cardiovascular diseases: a retrospective analysis. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/49760/

Chicago Manual of Style (16^th Edition):

Shaik, Riaz Basha, 1979-. “Hypercalcemia and Its effects on the cardiovascular diseases: a retrospective analysis.” 2016. Doctoral Dissertation, Rutgers University. Accessed January 19, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/49760/.

MLA Handbook (7^th Edition):

Shaik, Riaz Basha, 1979-. “Hypercalcemia and Its effects on the cardiovascular diseases: a retrospective analysis.” 2016. Web. 19 Jan 2021.

Vancouver:

Shaik, Riaz Basha 1. Hypercalcemia and Its effects on the cardiovascular diseases: a retrospective analysis. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Jan 19]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49760/.

Council of Science Editors:

Shaik, Riaz Basha 1. Hypercalcemia and Its effects on the cardiovascular diseases: a retrospective analysis. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49760/

McMaster University

20. Joseph, Philip G. THE IMPACT OF A CORONARY ARTERY DISEASE GENETIC RISK SCORE ON MYOCARDIAL INFARCTION RISK IN A MULTI-ETHNIC POPULATION: AN INTERHEART STUDY.

Degree: MSc, 2013, McMaster University

URL: http://hdl.handle.net/11375/13851

►

Background: Genome wide association studies (GWAS) performed in Caucasian populations have identified several single nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD), although… (more)

Subjects/Keywords: coronary artery disease; myocardial infarction; genetics; Cardiovascular Diseases; Cardiovascular Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Joseph, P. G. (2013). THE IMPACT OF A CORONARY ARTERY DISEASE GENETIC RISK SCORE ON MYOCARDIAL INFARCTION RISK IN A MULTI-ETHNIC POPULATION: AN INTERHEART STUDY. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/13851

Chicago Manual of Style (16^th Edition):

Joseph, Philip G. “THE IMPACT OF A CORONARY ARTERY DISEASE GENETIC RISK SCORE ON MYOCARDIAL INFARCTION RISK IN A MULTI-ETHNIC POPULATION: AN INTERHEART STUDY.” 2013. Masters Thesis, McMaster University. Accessed January 19, 2021. http://hdl.handle.net/11375/13851.

MLA Handbook (7^th Edition):

Joseph, Philip G. “THE IMPACT OF A CORONARY ARTERY DISEASE GENETIC RISK SCORE ON MYOCARDIAL INFARCTION RISK IN A MULTI-ETHNIC POPULATION: AN INTERHEART STUDY.” 2013. Web. 19 Jan 2021.

Vancouver:

Joseph PG. THE IMPACT OF A CORONARY ARTERY DISEASE GENETIC RISK SCORE ON MYOCARDIAL INFARCTION RISK IN A MULTI-ETHNIC POPULATION: AN INTERHEART STUDY. [Internet] [Masters thesis]. McMaster University; 2013. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/11375/13851.

Council of Science Editors:

Joseph PG. THE IMPACT OF A CORONARY ARTERY DISEASE GENETIC RISK SCORE ON MYOCARDIAL INFARCTION RISK IN A MULTI-ETHNIC POPULATION: AN INTERHEART STUDY. [Masters Thesis]. McMaster University; 2013. Available from: http://hdl.handle.net/11375/13851

21. Mbulo, Ann. A survey of Herbal medicine use in hypertensive patients at the University Teaching Hospital Lusaka,Zambia.

Degree: 2016, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/4243

► Introduction- Many mothers and their babies do not receive the recommended immediate postnatal care despite delivering from the hospital. At Ndola Central Hospital, there have… (more)

▼ Introduction- Many mothers and their babies do not receive the recommended immediate postnatal care despite delivering from the hospital. At Ndola Central Hospital, there have been reports of mothers complaining of poor health care provision. Records also revealed high numbers of neonatal and maternal mortality. Between 2011 and 2013, a total of 265 and 47 cases of neonatal and maternal mortality respectively were recorded. Maternal and Neonatal morbidity and mortality are the traditional measures of the quality of care. To complement them, a patient centered measure such as measuring levels of mothers’ satisfaction with the care is required. The objective of this study was to determine the levels of mothers’ satisfaction with the immediate postnatal care provided at Ndola Central Hospital. It also aimed at establishing the association between mothers’ satisfaction with the immediate postnatal care with socio demographic and obstetric characteristics. Mothers' opinions regarding their satisfaction with care can provide an opportunity to plan and implement appropriate strategies that improve the quality of care. Methodology -A hospital based cross sectional study was conducted at Ndola Central Hospital between November and December, 2014. Two hundred and two mothers in the immediate postnatal period were selected by purposive sampling method. A structured interview schedule adapted from the Jipi’s Satisfaction with Postnatal Nursing Care Questionnaire was employed for data collection. The tool had six satisfaction subscales namely; information, communication, care and comfort, value and preferences, orientation and care specific to postnatal; on a five point Likert scale. It also had 11 socio demographic and obstetric characteristics. Mothers were interviewed one at a time. Stata version 10.0 running on windows 7 was used for data analysis. Spearman’s correlation coefficient (r) was used to investigate the association between variables. Linear regression modeling was also applied to test the significance of the association. Results- Overall, 26.2 percent of the mothers were fully satisfied with the immediate postnatal care provided, 35.6 percent were moderately satisfied, 27.2 percent were minimally satisfied, 9.9 percent were satisfied and 1 percent was dissatisfied with the immediate postnatal care provided. Of the six satisfaction subscales, information scored the lowest (63.4%) while communication scored the highest (85.9%). Of the 11 socio demographic and obstetric characteristics only the mothers’ employment status (p- value = 0.024) and the baby’s condition at birth (p-value = 0.037) had statistically significant association with the mother’ satisfaction with the immediate postnatal care. Conclusion- The study showed that the levels of satisfaction with the immediate postnatal care provided at Ndola Central Hospital were low among mothers as it would have been preferred that more mothers than 26.2% reported to be fully satisfied with the care provided. Individualized and satisfactory care was not provided as…

Subjects/Keywords: Cardiovascular system – Diseases – Alternative treatment; Cardiovascular Diseases – therapy

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mbulo, A. (2016). A survey of Herbal medicine use in hypertensive patients at the University Teaching Hospital Lusaka,Zambia. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/4243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mbulo, Ann. “A survey of Herbal medicine use in hypertensive patients at the University Teaching Hospital Lusaka,Zambia.” 2016. Thesis, University of Zimbabwe. Accessed January 19, 2021. http://dspace.unza.zm/handle/123456789/4243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mbulo, Ann. “A survey of Herbal medicine use in hypertensive patients at the University Teaching Hospital Lusaka,Zambia.” 2016. Web. 19 Jan 2021.

Vancouver:

Mbulo A. A survey of Herbal medicine use in hypertensive patients at the University Teaching Hospital Lusaka,Zambia. [Internet] [Thesis]. University of Zimbabwe; 2016. [cited 2021 Jan 19]. Available from: http://dspace.unza.zm/handle/123456789/4243.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mbulo A. A survey of Herbal medicine use in hypertensive patients at the University Teaching Hospital Lusaka,Zambia. [Thesis]. University of Zimbabwe; 2016. Available from: http://dspace.unza.zm/handle/123456789/4243

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

22. Noorduyn, Stephen G. Cardiovascular events and their risk factors in adults with cerebral palsy.

Degree: MSc, 2013, McMaster University

URL: http://hdl.handle.net/11375/13883

►

Background Adults with cerebral palsy (CP) may have special health care considerations related to an increased prevalence of risk factors for chronic diseases. In… (more)

▼

Background Adults with cerebral palsy (CP) may have special health care considerations related to an increased prevalence of risk factors for chronic diseases. In particular, disability-related sedentary time may increase the risk of cardiovascular disease and the related major adverse cardiovascular events (MACE) in this population. Methods Part I: A systematic review of major databases, trial registries, and conference abstracts identified randomized trials and observational studies exploring the prevalence and evaluating the prevention of MACE and risk factors for MACE in adults with CP. Title and abstract, data extraction, and quality of reporting assessment were completed in duplicate. Part II: A secondary analysis of Canadian census data evaluated the crude and adjusted risk of stroke in adults with CP and compared the crude risk with other Canadian adults with spinal cord injury, acquired brain injury, and epilepsy. All risks were reported as an odds ratio (OR) with 95% confidence intervals. Results Part I: 2281 unique articles were screened to provide 10 cross-sectional studies. No studies evaluated any interventions for MACE or risk factors for MACE. The most common risk factor studied was obesity. Two studies showed an increased in death due to circulatory diseases. Part II: Crude risk of stroke to CP was OR=12.5 (12.2-12.9). Mediation effects or multicollinearity was not observed. The adjusted risk of stroke was OR=7.9 (1.8-34.2). Elevated crude risk of stroke was also noted in patients with acquired brain injury (OR=16.2 [16.0-16.5]), spinal cord injury (OR=6.1 [6.0-6.3]), and epilepsy (OR=6.2 [6.0-6.3]). Conclusions This thesis provides a preliminary overview of the risk of MACE in adults with CP and hypothesis generating evidence for further research in this population. A prospective cohort study is urgently needed assess the implications of these findings. Adults with CP should minimize exposure to modifiable risk factors as much as possible.

Master of Science (MSc)

Advisors/Committee Members: Gorter, Jan Willem, Hanna, Steven, Rosenbaum, Peter, Clinical Epidemiology/Clinical Epidemiology & Biostatistics.

Subjects/Keywords: cerebral palsy; adults; Canada; cardiovascular outcomes; stroke; Canadian Community Health Survey; Cardiovascular Diseases; Cardiovascular Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Noorduyn, S. G. (2013). Cardiovascular events and their risk factors in adults with cerebral palsy. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/13883

Chicago Manual of Style (16^th Edition):

Noorduyn, Stephen G. “Cardiovascular events and their risk factors in adults with cerebral palsy.” 2013. Masters Thesis, McMaster University. Accessed January 19, 2021. http://hdl.handle.net/11375/13883.

MLA Handbook (7^th Edition):

Noorduyn, Stephen G. “Cardiovascular events and their risk factors in adults with cerebral palsy.” 2013. Web. 19 Jan 2021.

Vancouver:

Noorduyn SG. Cardiovascular events and their risk factors in adults with cerebral palsy. [Internet] [Masters thesis]. McMaster University; 2013. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/11375/13883.

Council of Science Editors:

Noorduyn SG. Cardiovascular events and their risk factors in adults with cerebral palsy. [Masters Thesis]. McMaster University; 2013. Available from: http://hdl.handle.net/11375/13883

Bond University

23. Kiessling, Can Justin. Transcriptional analysis caveolae-related transcripts in the ischaemic- intolerant ageing mouse heart.

Degree: 2016, Bond University

URL: https://epublications.bond.edu.au/theses/146

► Ischaemic heart disease (IHD) is the most prevalent of the cardiovascular diseases and the largest single leading cause of death in Australia and other Western… (more)

Subjects/Keywords: Cardiovascular Diseases; Mice Diseases Pathophysiology.; Health Sciences, Medicine and Surgery (0564); Cardiology; Cardiovascular Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kiessling, C. J. (2016). Transcriptional analysis caveolae-related transcripts in the ischaemic- intolerant ageing mouse heart. (Thesis). Bond University. Retrieved from https://epublications.bond.edu.au/theses/146

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kiessling, Can Justin. “Transcriptional analysis caveolae-related transcripts in the ischaemic- intolerant ageing mouse heart.” 2016. Thesis, Bond University. Accessed January 19, 2021. https://epublications.bond.edu.au/theses/146.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kiessling, Can Justin. “Transcriptional analysis caveolae-related transcripts in the ischaemic- intolerant ageing mouse heart.” 2016. Web. 19 Jan 2021.

Vancouver:

Kiessling CJ. Transcriptional analysis caveolae-related transcripts in the ischaemic- intolerant ageing mouse heart. [Internet] [Thesis]. Bond University; 2016. [cited 2021 Jan 19]. Available from: https://epublications.bond.edu.au/theses/146.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kiessling CJ. Transcriptional analysis caveolae-related transcripts in the ischaemic- intolerant ageing mouse heart. [Thesis]. Bond University; 2016. Available from: https://epublications.bond.edu.au/theses/146

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

24. Vrugt, A.M. van de. Natural Killer T cells and their functions in atherosclerosis and obesity: a therapeutic perspective for cardiovascular diseases.

Degree: 2014, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/301208

► Atherosclerosis and obesity, both related to the development of cardiovascular diseases (CVDs), are increasing pathologies under the global population. Therefore, both pathologies contribute to the… (more)

Subjects/Keywords: NKT cells; Lipids; Cardiovascular Diseases; Atherosclerosis; Obesity

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vrugt, A. M. v. d. (2014). Natural Killer T cells and their functions in atherosclerosis and obesity: a therapeutic perspective for cardiovascular diseases. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/301208

Chicago Manual of Style (16^th Edition):

Vrugt, A M van de. “Natural Killer T cells and their functions in atherosclerosis and obesity: a therapeutic perspective for cardiovascular diseases.” 2014. Masters Thesis, Universiteit Utrecht. Accessed January 19, 2021. http://dspace.library.uu.nl:8080/handle/1874/301208.

MLA Handbook (7^th Edition):

Vrugt, A M van de. “Natural Killer T cells and their functions in atherosclerosis and obesity: a therapeutic perspective for cardiovascular diseases.” 2014. Web. 19 Jan 2021.

Vancouver:

Vrugt AMvd. Natural Killer T cells and their functions in atherosclerosis and obesity: a therapeutic perspective for cardiovascular diseases. [Internet] [Masters thesis]. Universiteit Utrecht; 2014. [cited 2021 Jan 19]. Available from: http://dspace.library.uu.nl:8080/handle/1874/301208.

Council of Science Editors:

Vrugt AMvd. Natural Killer T cells and their functions in atherosclerosis and obesity: a therapeutic perspective for cardiovascular diseases. [Masters Thesis]. Universiteit Utrecht; 2014. Available from: http://dspace.library.uu.nl:8080/handle/1874/301208

University of Zambia

25. Kabwe, Lorrita. Spectrum of sub-clinical cardiovascular diseases and relationship to the CD4 count among clinically health HIV infected patients at the university teaching hospital in Lusaka .

Degree: 2016, University of Zambia

URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4615

► Background: - Cardiovascular diseases are among the leading cause of morbidity and mortality worldwide. The association between HIV and CVD has been established in many… (more)

▼ Background: - Cardiovascular diseases are among the leading cause of morbidity and mortality worldwide. The association between HIV and CVD has been established in many studies. However, information is still lacking on subclinical disease as well as its associated risk factors in this population. This study aimed at establishing the prevalence of subclinical CVD among clinically healthy HIV people attending their regular out- patient visits. It also looked at risk factors (traditional and non traditional) as well as the association of CVD to the CD4 count. Methods: we enrolled a total of 243 asymptomatic HIV-infected patients from the HIV outpatient clinic at the University Teaching Hospital. Data collected included demographic characteristics, duration of HIV infection, drug history including HAART regimen and cardiovascular risk factors (hypertension, diabetes and smoking). Clinical data included blood pressure, weight and height. Laboratory data included CD4 counts, serum creatinine, total cholesterol and triglycerides. We tested for subclinical CVD using 3 tools: Ankle Brachial Index (ABI) to measure for the presence of peripheral artery disease, 12 lead Electrocardiogram (ECG) for electrical abnormalities and transthoracic Echocardiography (ECHO), to measure abnormalities in cardiac structure and function. At analysis, patients where dichotomised into those with CD4≤350 and those with CD4>350. Results: participants characteristics were as follows: the mean age, 42 years (SD±10); 143 (58.5%) females; CD4≤ 350cells/ml was found in 140 (57.6%); 112(86.2%) were receiving HAART with 86.2% being on 1st line regimen. Systolic hypertension was present in 84(34.6%), diastolic hypertension in 89(36.6%) and 39.5% had creatinine clearance<90. Diabetes and current smoking were not very common (3.3% and 2.9% respectively). High total cholesterol was found in 19(7.82%) of the participants while 37(15.23%) had high triglycerides. On ECG, ECHO and ABI, abnormalities were found in 53.9%, 44.4% and 20.2% respectively). The commonest cardiac lesion on both ECG and ECHO was left ventricular hypertrophy (27.4% and 23.3% respectively). Participants with CD4≤350 had higher prevalence of abnormalities on ECG (P=0.022) and ABI (P=0.043). Clinical factors associated with increased risk of subclinical CVD on multivariate logistical regression included CD4≤350, systolic BP>140mmHg and diastolic BP >90mmHg. Conclusions: prevalence of subclinical CVD in healthy HIV infected patients is high and those with CD4≤350 have a higher risk. Hypertension is the most important traditional CVD risk factor in this population. There is need to screen HIV patients attending their routine clinic visits for hypertension and subclinical CVD. ABI and ECG are readily available in most institutions and can be used with minimal expertise.

Subjects/Keywords: Cardiovascular system-diseases.; AIDS(Disease)-Complication.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kabwe, L. (2016). Spectrum of sub-clinical cardiovascular diseases and relationship to the CD4 count among clinically health HIV infected patients at the university teaching hospital in Lusaka . (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4615

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kabwe, Lorrita. “Spectrum of sub-clinical cardiovascular diseases and relationship to the CD4 count among clinically health HIV infected patients at the university teaching hospital in Lusaka .” 2016. Thesis, University of Zambia. Accessed January 19, 2021. http://dspace.unza.zm:8080/xmlui/handle/123456789/4615.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kabwe, Lorrita. “Spectrum of sub-clinical cardiovascular diseases and relationship to the CD4 count among clinically health HIV infected patients at the university teaching hospital in Lusaka .” 2016. Web. 19 Jan 2021.

Vancouver:

Kabwe L. Spectrum of sub-clinical cardiovascular diseases and relationship to the CD4 count among clinically health HIV infected patients at the university teaching hospital in Lusaka . [Internet] [Thesis]. University of Zambia; 2016. [cited 2021 Jan 19]. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4615.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kabwe L. Spectrum of sub-clinical cardiovascular diseases and relationship to the CD4 count among clinically health HIV infected patients at the university teaching hospital in Lusaka . [Thesis]. University of Zambia; 2016. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4615

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Drexel University

26. Nelson, Julianne Theresa. Impact of Apparent Treatment Resistant Hypertension on Cardiovascular Disease and Potential Biological and Pharmaceutical Interactions.

Degree: 2018, Drexel University

URL: https://idea.library.drexel.edu/islandora/object/idea%3A8020

►

Apparent Treatment Resistant Hypertension (ATRH) is a growing and serious concern in the U.S. affecting approximately 13% of hypertensive adults. Uncontrolled blood pressure has been… (more)

▼

Apparent Treatment Resistant Hypertension (ATRH) is a growing and serious concern in the U.S. affecting approximately 13% of hypertensive adults. Uncontrolled blood pressure has been connected to adverse health outcomes; however, little has been researched on long-term prognosis of individuals with ATRH. It is unclear how the relationship between ATRH and CVD would be modified by differing biological/demographic factors (age, sex, obesity, and diabetes), and first-line antihypertensive medications (diuretic, calcium channel blocker, and ACE inhibitor). Data was obtained from the Antihypertensive and Lipid Lowering to Prevent Heart Attack Trial (ALLHAT, N = 25,516) was used and ATRH was assessed from the year 2 follow-up visit (N = 2,329). Cox Proportional Hazards models were used to analyze the relationship between ATRH and CVD. Two-way interactions were analyzed (modifier*ATRH) and results suggested which three-way interactions to test (modifier*modifier*ATRH). Effect modification on the multiplicative scale and additive scale was assessed through use of product terms in the Cox model, heterogeneity of effects, and joint effects. CVD event was the outcome (N=5,030) of interest. ATRH was associated with a 30% increase in risk of CVD (HR 1.3 95% CI 1.19-1.42). Sex and age were found to modify the relationship of ATRH and CVD on both scales. Among women, ATRH was associated with a 62% increase in risk of CVD event (95% CI 1.41 - 1.86) while among men, ATRH was associated with a 14% increase in risk of CVD (95% CI 1.01 - 1.28). ATRH had a stronger impact on risk of CVD among younger subjects than it did among older (HR 1.55, 95% CI 1.33 - 1.79 and HR 1.18, 95% CI 1.05 - 1.32 respectively). No significant two-way effect modification by drug class was observed on either the multiplicative or additive scale. Potential three-way interaction was observed for both ATRH*Sex*Age and ATRH*Sex*Drug. The observed joint effect of being male, with ATRH, and on Lisinopril or Amlodipine on CVD risk (HR 1.39, 95% CI 0.73 - 2.06 and HR 1.55, 95% CI 0.87 - 2.22 respectively) was less than what was expected for both the multiplicative and additive models. The observed joint effect of being male, with ATRH and 65 years or older (HR 1.85, 95% CI 1.22 - 2.48) was less than what was expected for both additive and multiplicative models (HRs 4.10, 95% CI 3.63 - 4.57 and 4.88, 95% CI 3.66 - 6.31 respectively). The sub-multiplicative two-way interaction with ATRH*sex was a main driver in both observed three-way interactions. Our findings indicate that patient sex should be taken into consideration when considering ways to improve awareness, diagnosis, treatment, and management of ATRH. Future research should focus on these observed gender differences in patient outcomes with ATRH with specific focus on the underlying mechanisms at play in this relationship.

Ph.D., Epidemiology – Drexel University, 2018

Advisors/Committee Members: Liu, Longjian, Dana and David Dornsife School of Public Health.

Subjects/Keywords: Epidemiology; Public health; Hypertension; Cardiovascular system – Diseases

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nelson, J. T. (2018). Impact of Apparent Treatment Resistant Hypertension on Cardiovascular Disease and Potential Biological and Pharmaceutical Interactions. (Thesis). Drexel University. Retrieved from https://idea.library.drexel.edu/islandora/object/idea%3A8020

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nelson, Julianne Theresa. “Impact of Apparent Treatment Resistant Hypertension on Cardiovascular Disease and Potential Biological and Pharmaceutical Interactions.” 2018. Thesis, Drexel University. Accessed January 19, 2021. https://idea.library.drexel.edu/islandora/object/idea%3A8020.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nelson, Julianne Theresa. “Impact of Apparent Treatment Resistant Hypertension on Cardiovascular Disease and Potential Biological and Pharmaceutical Interactions.” 2018. Web. 19 Jan 2021.

Vancouver:

Nelson JT. Impact of Apparent Treatment Resistant Hypertension on Cardiovascular Disease and Potential Biological and Pharmaceutical Interactions. [Internet] [Thesis]. Drexel University; 2018. [cited 2021 Jan 19]. Available from: https://idea.library.drexel.edu/islandora/object/idea%3A8020.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nelson JT. Impact of Apparent Treatment Resistant Hypertension on Cardiovascular Disease and Potential Biological and Pharmaceutical Interactions. [Thesis]. Drexel University; 2018. Available from: https://idea.library.drexel.edu/islandora/object/idea%3A8020

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oxford

27. Broyles, Connor Neil. Characterisation of dynamic cellular processes in human stem cell models of inherited cardiomyopathy using genetically encoded reporters.

Degree: PhD, 2020, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:c13a7f54-e9f4-413e-9c2c-13d2e1e55f03 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.800165

► The demonstrated number 1 killer in the world is cardiovascular disease, with inherited cardiomyopathies the more dramatic scenario as children are forced to live with… (more)

▼ The demonstrated number 1 killer in the world is cardiovascular disease, with inherited cardiomyopathies the more dramatic scenario as children are forced to live with the condition from an early age. Small genetic changes to the myofilament proteins in cardiac myocytes can result in either hypertrophic cardiomyopathy where the heart becomes enlarged and fails to relax efficiently, or dilated cardiomyopathy where the chambers of the heart stretch and are unable to appropriately contract. Either case results in inefficient delivery of vital oxygen and nutrients to the body. However it is not simply that one gene causes hypertrophy or dilation, but rather that single mutations within the same gene can cause either disease. This complicates how the diseases are understood, and the search for treatments. To address this, individual mutations must be investigated and specific molecular pathologies known, in order to effectively target the true problem when managing the condition; forcing researchers to focus on individual families containing the mutation, resulting in personalised approaches to medical treatment. This thesis investigates two mutations found in different families that are known to result in hypertrophic and dilated cardiomyopathy: Troponin I arginine 145 → glycine (R145G) and Troponin T arginine 141 → tryptophan (R141W) respectively. This is performed in human stem cell derived cardiac myocytes, using novel genetically encoded reporters for detection of protein localisation and calcium ion sensing specifically at the myofilament. Because stem cell derived cardiac myocytes have foetal-like appearances and physiology, the outset of this work aimed to define if cells could be improved for greater myofilament alignment, sarcomere function, and calcium physiology by extending the time of culture prior to experimentation. In the later half of this thesis, the disease cases are investigated with wild- type cells after applying mutant versions of the genetic reporters used for characterisation of the dynamic functions, and novel patient derived cell lines; permitting characterisation of cells already containing the mutation. The first two chapters investigating cell structure, function and calcium physiology identified that maintaining the cells for 50 or more days beyond the initiation of the stem cell directed differentiation to cardiac myocytes was sufficient in evoking reliable and improved cellular appearances. These efforts also introduced the idea that troponin I and T have a certain degree of molecular mobility, observed via fluorescence recovery after photobleaching, that could potentially play a role in disease. Investigation of the hypertrophy causing mutation (R145G) revealed an increase in Troponin I mobility, and mutant cells with myofilament disarray and prolonged calcium transients that are expected of the disease. The increase in troponin I mobility with the mutation fits with the current knowledge of the sarcomere remaining active during relaxation; presenting a potential disease mechanism where…

Subjects/Keywords: Cardiovascular system – Diseases; Troponin; Troponin Mobility

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Broyles, C. N. (2020). Characterisation of dynamic cellular processes in human stem cell models of inherited cardiomyopathy using genetically encoded reporters. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:c13a7f54-e9f4-413e-9c2c-13d2e1e55f03 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.800165

Chicago Manual of Style (16^th Edition):

Broyles, Connor Neil. “Characterisation of dynamic cellular processes in human stem cell models of inherited cardiomyopathy using genetically encoded reporters.” 2020. Doctoral Dissertation, University of Oxford. Accessed January 19, 2021. http://ora.ox.ac.uk/objects/uuid:c13a7f54-e9f4-413e-9c2c-13d2e1e55f03 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.800165.

MLA Handbook (7^th Edition):

Broyles, Connor Neil. “Characterisation of dynamic cellular processes in human stem cell models of inherited cardiomyopathy using genetically encoded reporters.” 2020. Web. 19 Jan 2021.

Vancouver:

Broyles CN. Characterisation of dynamic cellular processes in human stem cell models of inherited cardiomyopathy using genetically encoded reporters. [Internet] [Doctoral dissertation]. University of Oxford; 2020. [cited 2021 Jan 19]. Available from: http://ora.ox.ac.uk/objects/uuid:c13a7f54-e9f4-413e-9c2c-13d2e1e55f03 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.800165.

Council of Science Editors:

Broyles CN. Characterisation of dynamic cellular processes in human stem cell models of inherited cardiomyopathy using genetically encoded reporters. [Doctoral Dissertation]. University of Oxford; 2020. Available from: http://ora.ox.ac.uk/objects/uuid:c13a7f54-e9f4-413e-9c2c-13d2e1e55f03 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.800165

Stellenbosch University

28. Otto, Delita. Exploring underlying mechanisms driving the onset of stress-induced insulin resistance.

Degree: MSc, Physiological Sciences, 2012, Stellenbosch University

URL: http://hdl.handle.net/10019.1/20125

►

ENGLISH ABSTRACT: Physical and psychological stressors trigger activation of the hypothalamo-pituitary-adrenocortical (HPA) axis that leads to enhanced secretion of glucocorticoids e.g. cortisol. Moreover, chronic activation… (more)

▼

ENGLISH ABSTRACT: Physical and psychological stressors trigger activation of the hypothalamo-pituitary-adrenocortical (HPA) axis that leads to enhanced secretion of glucocorticoids e.g. cortisol. Moreover, chronic activation of this pathway may elevate oxidative stress that is linked to the onset of insulin resistance and cardiovascular diseases (CVD). Our laboratory previously found that oxidative stress increases flux through metabolic circuits such as the hexosamine biosynthetic pathway (HBP), in effect increasing its modification of target proteins post-transcriptionally with O-GlcNAc moeities. This in turn may alter protein function and contribute to the onset of myocardial insulin resistance and impaired contractile function. Since the underlying mechanisms linking chronic stress to cardiometabolic pathophysiology are poorly understood, we hypothesised that cortisol elicits myocardial oxidative stress, HBP activation, and decreased glucose uptake (due to attenuated glucose transport functionality) with detrimental outcomes, i.e. insulin resistance and apoptosis. To investigate this hypothesis we established an in vitro model using HL-1 cardiomyocytes, with which we evaluated the degree of O-GlcNAcylation and oxidative stress in response to a range of time-dose treatments with dexamethasone (synthetic glucocorticoid). Glucose transporter 4 (GLUT4) translocation to the sarcolemma was also assessed. In agreement with the literature, results suggest that GLUT4 translocation is significantly decreased subsequent to dexamethasone treatment. Although no significant differences were observed with regards to oxidative stress or O-GlcNAcylation, the data show that dexamethasone increased the latter with a maximal effect after two hours exposure to the 10-6 M dose. Although our results were not conclusive, the data suggest a potential novel link between dexamethasone exposure, HBP activation and decreased GLUT4 translocation. Based on our findings we propose that detrimental effects of chronic stress on the heart may be mediated by increased HBP flux. Given that glucocorticoid excess and GLUT4 dysregulation have been associated with insulin resistance (and related metabolic derangements and diseases), these results provide new targets for potential therapeutic agents.

AFRIKAANSE OPSOMMING: Fisiese sowel as psigologiese stressors veroorsaak die aktivering van die hipotalamiese-hipo seale-bynier (HHB) pad wat lei tot die verhoogde sekresie van glukokortikoïede soos kortisol. Kroniese aktivering van hierdie pad kan ook oksidatiewe stres verhoog wat weer tot insulienweerstandigheid en kardiovaskulêre siektes (KVS) kan lei. Navorsing uit ons laboratorium het voorheen bewys dat oksidatiewe stres 'n toename in vloei deur metaboliese paaie soos die heksoamine biosintetiese pad (HBP) kan veroorsaak deur die modi sering van teikenproteïene met O-GlcNAc motiewe. Dit kan weer proteïen funksie verander en bydra tot die ontstaan van miokardiale insulienweerstandigheid en verswakte kontraktiele funksie.…

Advisors/Committee Members: Essop, M. F., Stellenbosch University. Faculty of Science. Dept. of Physiological Sciences..

Subjects/Keywords: Physiology (Human and animal); Cardiovascular diseases; Apoptosis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Otto, D. (2012). Exploring underlying mechanisms driving the onset of stress-induced insulin resistance. (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/20125

Chicago Manual of Style (16^th Edition):

Otto, Delita. “Exploring underlying mechanisms driving the onset of stress-induced insulin resistance.” 2012. Masters Thesis, Stellenbosch University. Accessed January 19, 2021. http://hdl.handle.net/10019.1/20125.

MLA Handbook (7^th Edition):

Otto, Delita. “Exploring underlying mechanisms driving the onset of stress-induced insulin resistance.” 2012. Web. 19 Jan 2021.

Vancouver:

Otto D. Exploring underlying mechanisms driving the onset of stress-induced insulin resistance. [Internet] [Masters thesis]. Stellenbosch University; 2012. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10019.1/20125.

Council of Science Editors:

Otto D. Exploring underlying mechanisms driving the onset of stress-induced insulin resistance. [Masters Thesis]. Stellenbosch University; 2012. Available from: http://hdl.handle.net/10019.1/20125

Stellenbosch University

29. Fisher, Leslie Reginald. Evaluation of high-throughput methodology for multi-gene screening in patients with Non-Alcoholic Fatty Liver Disease (NAFLD).

Degree: MScMedSc, Pathology, 2011, Stellenbosch University

URL: http://hdl.handle.net/10019.1/17896

► ENGLISH ABSTRACT: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent chronic liver disease in Western countries and is considered the hepatic manifestation of the… (more)

▼ ENGLISH ABSTRACT: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent chronic liver disease in Western countries and is considered the hepatic manifestation of the Metabolic Syndrome (MetS). Its heterogeneous nature ranges from hepatic steatosis through steatohepatitis to advanced fibrosis and cirrhosis where the ingestion of significant amounts of alcohol has been excluded. The disease profile of NAFLD and its necro-inflammatory subset Nonalcoholic Steatohepatitis (NASH) were described in the parent study, which provided a clinically well-characterised patient cohort for the present investigation. South African patients with NASH had significantly higher mean serum cholesterol and triglyceride levels than those with fatty liver only. The objective of this study was to implement a high-throughput real-time polymerase chain reaction (PCR) method in our laboratory to enable the assessment of cardiovascular genetic risk factors in NAFLD patients. The specific aims were to determine the clinical utility and perform analytical validation of each mutation included in the multi-gene cardiovascular disease (CVD) screening assay. The Pathology Supported Genetic Testing (PSGT) concept developed at our department provides a practical approach to personalized medicine. The CVD multi-gene screen analyses key metabolic pathways relating to atherogenic dyslipidaemia, chronic inflammation, hypercoagulation and iron dysregulation implicated in insulin resistance, which is known to be a universal factor in the pathogenesis of NAFLD. Deleterious low-penetrance mutations in the APOE (APOE2 and E4 alleles), MTHFR (677C>T and 1298A>C), F2 (20210G>A), FV (1691G>A, Leiden) and HFE (C282Y and H63D) genes were included for analysis due to their important role as genetic contributors to these biological processes. A total of 178 patients diagnosed with NAFLD and 75 controls were studied using direct DNA sequencing and a RT-PCR system for mutation detection. In addition, two patients with high ferritin levels were included as case studies. A significant association was found between HFE mutations and elevated Alanine Transaminase (ALT) levels in the NAFLD population (p = 0.04). This discovery is interpreted as the identification of a subset of patients at greater risk of developing progressive liver damage who would benefit most from genetic testing to direct more aggressive therapy at an earlier stage. The necessity of an integrative, systems-based network approach was demonstrated to more accurately distinguish between Hereditary Haemochromatosis (HH) and Insulin Resistance-associated Hepatic Iron Overload (IR-HIO) syndrome in obese patients. The PSGT approach to personalized medicine facilitates diagnosis of CVD subtypes, prevention of cumulative risk and the formulation of gene-based intervention programs tailored to the needs of the patient. These findings support the clinical utility of the CVD multi-gene test to guide chronic disease risk management in patients with NAFLD. The HFE mutation detection component of this test… Advisors/Committee Members: Kotze, Maritha J., Kruger, F. C., Stellenbosch University. Faculty of Health Sciences. Dept. of Pathology..

Subjects/Keywords: Pathology; Dissertations – Pathology; Cardiovascular system – Diseases; Pathology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fisher, L. R. (2011). Evaluation of high-throughput methodology for multi-gene screening in patients with Non-Alcoholic Fatty Liver Disease (NAFLD). (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/17896

Chicago Manual of Style (16^th Edition):

Fisher, Leslie Reginald. “Evaluation of high-throughput methodology for multi-gene screening in patients with Non-Alcoholic Fatty Liver Disease (NAFLD).” 2011. Masters Thesis, Stellenbosch University. Accessed January 19, 2021. http://hdl.handle.net/10019.1/17896.

MLA Handbook (7^th Edition):

Fisher, Leslie Reginald. “Evaluation of high-throughput methodology for multi-gene screening in patients with Non-Alcoholic Fatty Liver Disease (NAFLD).” 2011. Web. 19 Jan 2021.

Vancouver:

Fisher LR. Evaluation of high-throughput methodology for multi-gene screening in patients with Non-Alcoholic Fatty Liver Disease (NAFLD). [Internet] [Masters thesis]. Stellenbosch University; 2011. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/10019.1/17896.

Council of Science Editors:

Fisher LR. Evaluation of high-throughput methodology for multi-gene screening in patients with Non-Alcoholic Fatty Liver Disease (NAFLD). [Masters Thesis]. Stellenbosch University; 2011. Available from: http://hdl.handle.net/10019.1/17896

University of Texas Southwestern Medical Center

30. Falkowski, Jed Andrew. The Relationship Between Duration of Metabolic Syndrome and Cognitive Functioning.

Degree: 2014, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/3593

► The metabolic syndrome is defined by ≥ 3 of the following: Elevated blood glucose, triglycerides, waist circumference, and blood pressure as well as low levels… (more)

▼ The metabolic syndrome is defined by ≥ 3 of the following: Elevated blood glucose, triglycerides, waist circumference, and blood pressure as well as low levels of high-density lipoprotein. Research has linked cardiovascular risk factors composing metabolic syndrome with decrements in cognition, which may relate to prolonged metabolic syndrome presence. This project aimed to determine the relationship between metabolic syndrome status over time and cognitive performance, whether this relationship varies by cognitive domain, and assess if metabolic syndrome status across time predicts later cognitive impairment, with further exploration of age, race, gender, income, education, exercise, alcohol, and smoking effects in a racially diverse sample. Subjects included 1,314 individuals for whom archival Dallas Heart Study data for metabolic syndrome were available across two time points, including baseline and follow-up 2-9 years later as well as brief cognitive testing at follow-up, with 137 individuals who had additional cognitive testing and consensus diagnosis of cognitive impairment as part of the University of Texas Southwestern Alzheimer’s Disease Center Dallas Heart/Brain Aging Study. Total Montreal Cognitive Assessment score means were compared with 3 levels of metabolic syndrome status: Presence at 1) baseline and follow-up, 2) only at baseline, and 3) absent at both time points within the overall sample. Comparisons were made within homogenous subsamples grouped by age, gender, race, exercise, and education performed with inclusion of those who met metabolic syndrome criteria at baseline but not follow-up. Covariates included age, education, income, gender, race, smoking, cardio-respiratory fitness, and alcohol consumption when significant (p < .15). The relationship between duration of the syndrome and cognitive functioning was modest, but significant among African American women, African Americans with at least 12 years of education, and men ≥ age 55. Follow-up analyses found that presence of metabolic syndrome at follow-up was related to cognition among African Americans ≥ age 55. Conclusion: Though effects are small, African American race may place an individual at risk of cognitive effects of metabolic syndrome independent of other demographic and lifestyle factors, particularly for women, and reversing the syndrome may mitigate associated decrements in cognitive functioning among some groups. Advisors/Committee Members: Lacritz, Laura H., Weiner, Myron F., Rossetti, Heidi, Hynan, Linda S., Cullum, C. Munro.

Subjects/Keywords: Cardiovascular Diseases; Cognition Disorders; Metabolic Syndrome X

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Falkowski, J. A. (2014). The Relationship Between Duration of Metabolic Syndrome and Cognitive Functioning. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/3593

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Falkowski, Jed Andrew. “The Relationship Between Duration of Metabolic Syndrome and Cognitive Functioning.” 2014. Thesis, University of Texas Southwestern Medical Center. Accessed January 19, 2021. http://hdl.handle.net/2152.5/3593.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Falkowski, Jed Andrew. “The Relationship Between Duration of Metabolic Syndrome and Cognitive Functioning.” 2014. Web. 19 Jan 2021.

Vancouver:

Falkowski JA. The Relationship Between Duration of Metabolic Syndrome and Cognitive Functioning. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2014. [cited 2021 Jan 19]. Available from: http://hdl.handle.net/2152.5/3593.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Falkowski JA. The Relationship Between Duration of Metabolic Syndrome and Cognitive Functioning. [Thesis]. University of Texas Southwestern Medical Center; 2014. Available from: http://hdl.handle.net/2152.5/3593

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations