subject:(Candida albicans)

1. Scaduto, Christine Maria. Mechanisms of Sexual Reproduction in Human Fungal Pathogens.

Degree: Department of Molecular Biology, Cell Biology and Biochemistry, 2018, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:792587/

► Sexual reproduction typically involves fusion of haploid gametes to form diploid cells, which subsequently undergo meiosis to regenerate the haploid form. Despite the ubiquity of… (more)

Subjects/Keywords: Candida albicans

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APA (6^th Edition):

Scaduto, C. M. (2018). Mechanisms of Sexual Reproduction in Human Fungal Pathogens. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792587/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Scaduto, Christine Maria. “Mechanisms of Sexual Reproduction in Human Fungal Pathogens.” 2018. Thesis, Brown University. Accessed March 02, 2021. https://repository.library.brown.edu/studio/item/bdr:792587/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Scaduto, Christine Maria. “Mechanisms of Sexual Reproduction in Human Fungal Pathogens.” 2018. Web. 02 Mar 2021.

Vancouver:

Scaduto CM. Mechanisms of Sexual Reproduction in Human Fungal Pathogens. [Internet] [Thesis]. Brown University; 2018. [cited 2021 Mar 02]. Available from: https://repository.library.brown.edu/studio/item/bdr:792587/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Scaduto CM. Mechanisms of Sexual Reproduction in Human Fungal Pathogens. [Thesis]. Brown University; 2018. Available from: https://repository.library.brown.edu/studio/item/bdr:792587/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University

2. Stone, Wendy. An external ecological niche for Candida albicans within reducing, oxygen-limited zones of wetlands and riverbanks.

Degree: MSc, Microbiology, 2011, Stellenbosch University

URL: http://hdl.handle.net/10019.1/6892

► ENGLISH ABSTRACT: The ascomycetous yeast, Candida albicans, has been almost exclusively studied in a clinical context, due to the medical risk and costs associated with… (more)

▼ ENGLISH ABSTRACT: The ascomycetous yeast, Candida albicans, has been almost exclusively studied in a clinical context, due to the medical risk and costs associated with the yeast. Most environmental research into the external survival of this opportunistic pathogen has been concerned with short-term, severe pollution challenges. However, a study of literature indicates that the habitat characteristics of the oxygenlimited zones in wetlands and riverbanks are comparable to those of the gastrointestinal source of sewage-borne C. albicans. Interestingly, these are the external, environmental regions to which sewage-borne C. albicans is often exposed. In addition, oxygen-limitation is the predominant parameter in stimulating conjugation of C. albicans. Based on these observations, this study aimed to assess polluted river bank and wetland environments in the Western Cape of South Africa as potential habitats to accommodate a niche for C. albicans, particularly comparing the presence of this yeast in oxygen-limited, plant debris-rich zones and aerobic, clear, flowing zones. The second objective was to employ in vitro microcosm studies to investigate the survival and growth of C. albicans in various microhabitats similar to those comprising the oxygen-limited zones of wetlands. These included the rhizosphere of wetland flora, various soil and mud types and decomposing plant debris. The final objective was to establish the presence of sufficient nutrient and energy sources within this environment for the growth of C. albicans. In particular, cellulosic substrates and mono- and disaccharides released by the natural degradation of wetland plant debris were investigated as potential energy sources for this human commensal in the wetland environment. These study objectives combined to demonstrate the potential of such an oxygen-limited, plant debris-rich environment as a niche for C. albicans external to its human host. Both semi-quantitative culturing techniques and quantitative Real-Time PCR demonstrated the improved survival of C. albicans in oxygen-limited, plant debris-rich zones in wetland and river bank environments, in comparison to aerobic, clear subsurface water zones in the same environments. These zones were compared in the Plankenburg and Diep Rivers, situated in the Western Cape of South Africa. Correlations between coliform concentrations and total yeast concentrations were demonstrated in each of the different river zones, with higher pollution levels characteristic of the dry season. Candida albicans numbers in flowing water (zone W), rock-filtered (zone R) and plant-filtered water (zone P) were compared during the progress of the rainy and dry seasons. No C. albicans was observed in clear, flowing water throughout the analysis. Early in the rainy season, both rock-filtered (aerobic, poor in plant debris) and plant-filtered (oxygen-limited, rich in plant debris) water demonstrated C. albicans numbers at approximately equivalent levels of 10²-10³ cells/100 mL. However, as the rainy … Advisors/Committee Members: Botha, Alf, Wilsenach, Jac, Stellenbosch University. Faculty of Science. Dept. of Microbiology..

Subjects/Keywords: Candida albicans; Candida albicans – Survival; UCTD

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APA (6^th Edition):

Stone, W. (2011). An external ecological niche for Candida albicans within reducing, oxygen-limited zones of wetlands and riverbanks. (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/6892

Chicago Manual of Style (16^th Edition):

Stone, Wendy. “An external ecological niche for Candida albicans within reducing, oxygen-limited zones of wetlands and riverbanks.” 2011. Masters Thesis, Stellenbosch University. Accessed March 02, 2021. http://hdl.handle.net/10019.1/6892.

MLA Handbook (7^th Edition):

Stone, Wendy. “An external ecological niche for Candida albicans within reducing, oxygen-limited zones of wetlands and riverbanks.” 2011. Web. 02 Mar 2021.

Vancouver:

Stone W. An external ecological niche for Candida albicans within reducing, oxygen-limited zones of wetlands and riverbanks. [Internet] [Masters thesis]. Stellenbosch University; 2011. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10019.1/6892.

Council of Science Editors:

Stone W. An external ecological niche for Candida albicans within reducing, oxygen-limited zones of wetlands and riverbanks. [Masters Thesis]. Stellenbosch University; 2011. Available from: http://hdl.handle.net/10019.1/6892

Massey University

3. Zhang, Ningxin. Sex has no detectable net benefits for Candida albicans.

Degree: PhD, Molecular Microbiology, 2012, Massey University

URL: http://hdl.handle.net/10179/3679

► Like many other important opportunistic human fungal pathogens, for more than a century Candida albicans was thought to be strictly asexual until a parasexual cycle… (more)

▼ Like many other important opportunistic human fungal pathogens, for more than a century Candida albicans was thought to be strictly asexual until a parasexual cycle was recently discovered in the laboratory. It is uncertain, however, whether sex is still a viable reproductive strategy for C. albicans. In this study I tested whether or not mating enhanced survival of parental genes in this yeast, by mating 10 clinical isolates and testing recombinants’ fitness. Clinical isolates of C.albicans usually are diploid, carrying both the MTLa and MTLα mating type alleles, each on a different copy of chromosome 5. These strains are apparently incapable of meiosis and cannot mate with each other, because the a1-α2 heterodimer suppresses mating. Through selection on sorbose-containing agar I induced loss of MTL-heterozygosity and generated 5 MTLa and 5 MTLα derivatives of clinical isolates. Existing mating techniques involve the use of auxotrophic markers, requiring time-consuming sequential disruption of two copies of biosynthetic genes if wild-type clinical isolates are to be mated. Furthermore, auxotrophy affects the virulence of a strain, and this can potentially interfere with comparing the fitness of recombinants with that of their parents. I therefore developed a method for mating clinical isolates marked with two drug resistance markers, the mycophenolic acid (MPA) resistance-conferring allele of IMH3 and the nourseothricin (NAT) resistance gene CaNAT1, allowing selection of recombinants on the basis of resistance to both agents. I marked all MTLa strains with the MPA resistance gene and all MTLα strains with the NAT resistance gene. This allowed 25 combinations for mating. Recombinants were obtained from 15 combinations of 9 strains. It was found that not all C. albicans clinical isolates could mate. Using growth rate as the criterion, I tested the fitness of clinical isolates, MTLhomozygous derivatives with and without resistance markers and recombinants during adaptation to a novel environment (YPD medium), maximizing the potential benefits of sex. After computationally correcting for the impact of experimental manipulations, I calculated the net benefit of sex as the difference in the number of offspring from two cells that become mating competent and engage in sex compared to the offspring they could have produced by continued clonal reproduction. My results indicated that, as a rule, engaging in sex reduces the chances of survival of C. albicans’ genes, in part because MTL homozygosis significantly reduced growth rates. Through fitness increase after recombination, sex may eventually confer a net benefit for some strain combinations in the laboratory, but this probably occurs too late to prevent elimination of recombinants by competition and genetic drift in nature. Sex in C. albicans therefore diminished parents’ chances to pass on their genes to future generations. These findings have a significant impact on the assessment of the role of sex in C. albicans and other …

Subjects/Keywords: Pathogenic fungi; Candida albicans; Candida albicans reproduction

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APA (6^th Edition):

Zhang, N. (2012). Sex has no detectable net benefits for Candida albicans. (Doctoral Dissertation). Massey University. Retrieved from http://hdl.handle.net/10179/3679

Chicago Manual of Style (16^th Edition):

Zhang, Ningxin. “Sex has no detectable net benefits for Candida albicans.” 2012. Doctoral Dissertation, Massey University. Accessed March 02, 2021. http://hdl.handle.net/10179/3679.

MLA Handbook (7^th Edition):

Zhang, Ningxin. “Sex has no detectable net benefits for Candida albicans.” 2012. Web. 02 Mar 2021.

Vancouver:

Zhang N. Sex has no detectable net benefits for Candida albicans. [Internet] [Doctoral dissertation]. Massey University; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10179/3679.

Council of Science Editors:

Zhang N. Sex has no detectable net benefits for Candida albicans. [Doctoral Dissertation]. Massey University; 2012. Available from: http://hdl.handle.net/10179/3679

Université Laval

4. Chaillot, Julien. Étude de l'homéostasie de la taille chez la levure opportuniste Candida albicans.

Degree: 2019, Université Laval

URL: http://hdl.handle.net/20.500.11794/35434

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L’homéostasie de la taille est un processus important de la prolifération cellulaire mais les mécanismes moléculaires sont mal compris. Les cellules eucaryotes doivent atteindre une… (more)

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L’homéostasie de la taille est un processus important de la prolifération cellulaire mais les mécanismes moléculaires sont mal compris. Les cellules eucaryotes doivent atteindre une taille seuil avant la division, ce qui permet de maintenir une taille constante sur le long terme. Ce processus est régulé à un point de contrôle, à la fin de la phase G1, appelé START chez les levures. Le contrôle de la taille cellulaire a été étudié chez la levure modèle Saccharomyces cerevisiae mais n’a jamais été étudié chez les levures pathogènes. Dans cette thèse, nous avons utilisé Candida albicans comme organisme modèle pour étudier la régulation de la taille chez les levures opportunistes. Nous avons criblé des collections de mutants de délétions hétérozygotes et homozygotes de C.albicans afin d’identifier des gènes régulateurs de la taille. Nous avons analysé la distribution de taille de 279 mutants homozygotes et 4 348 mutants hétérozygotes (recouvrant 90% du génome). Nous avons comparé nos résultats à différents criblages effectués sur la levure modèle S.cerevisiae. Ces comparaisons montrent que peu de régulateurs sont conservés entre C. albicans et S. cerevisiae et que la régulation de la taille est processus très plastique. Par exemple, le mutant dot6 a un phénotype petit chez C. albicans mais n’a pas de phénotype de taille chez S. cerevisiae. Nous avons montré que Dot6 est un facteur de transcription nécessaire pour l’activation des gènes de la biogénèse des ribosomes. Dot6 est également un régulateur de START et joue un rôle dans l’adaptation de la taille suivant les sources de carbone disponibles. Nous avons également mis en évidence un nouveau rôle pour la protéine kinase Hog1/p38 dans la régulation de la taille chez C. albicans en absence de stress. Ce rôle n’a jamais été démontré chez S. cerevisiae. Nous avons montré que Hog1, ainsi que toute la voie HOG, sont des régulateurs négatifs de START. Nous avons mis en évidence que Hog1 régule à la fois la croissance cellulaire via Sfp1, un régulateur majeur de la biogénèse des ribosomes et des protéines ribosomales, et le cycle cellulaire via le complexe SBF (Swi4/Swi6), des facteurs de transcription nécessaires pour la transition G1/S. Nous avons également découvert qu’Ahr1, un facteur de transcription n’ayant pas d’orthologue chez S. cerevisiae, est nécessaire pour la régulation de la taille et aussi requis pour l’adaptation de la taille en fonction des acides aminés disponibles. Nous avons montré qu’Ahr1 agit dans la voie Tor1-Sch9 et régule négativement START. En conclusion, notre travail a permis de découvrir de nouveaux régulateurs de START, de caractériser leur fonction et de les placer dans différentes voies. Comme la dérégulation de la voie Hog1/p38 est associée à des pathologies humaines, nous proposons C.albicans comme organisme modèle pour l’étude de cette voie et son implication dans l’homéostasie de la taille chez les organismes eucaryotes.

Cell size homeostasis is an important process of cell proliferation but the molecular mechanisms are poorly understood.…

Advisors/Committee Members: Sellam, Adnane.

Subjects/Keywords: Homéostasie; Candida albicans

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APA (6^th Edition):

Chaillot, J. (2019). Étude de l'homéostasie de la taille chez la levure opportuniste Candida albicans. (Thesis). Université Laval. Retrieved from http://hdl.handle.net/20.500.11794/35434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chaillot, Julien. “Étude de l'homéostasie de la taille chez la levure opportuniste Candida albicans.” 2019. Thesis, Université Laval. Accessed March 02, 2021. http://hdl.handle.net/20.500.11794/35434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chaillot, Julien. “Étude de l'homéostasie de la taille chez la levure opportuniste Candida albicans.” 2019. Web. 02 Mar 2021.

Vancouver:

Chaillot J. Étude de l'homéostasie de la taille chez la levure opportuniste Candida albicans. [Internet] [Thesis]. Université Laval; 2019. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/20.500.11794/35434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chaillot J. Étude de l'homéostasie de la taille chez la levure opportuniste Candida albicans. [Thesis]. Université Laval; 2019. Available from: http://hdl.handle.net/20.500.11794/35434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

5. Kiss, Ágnes. A Candida albicans környezeti stressz indukálta morfológiai változásai .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2011, University of Debrecen

URL: http://hdl.handle.net/2437/118229

► A Candida albicans az emberi szervezetből leggyakrabban izolált opportunista patogén élesztőgomba, melynek környezeti stresszre adott morfológiai átalakulásait vizsgáltuk. Tanulmányok szerint a C. albicans a központi… (more)

Subjects/Keywords: Candida albicans; morfológia

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APA (6^th Edition):

Kiss, �. (2011). A Candida albicans környezeti stressz indukálta morfológiai változásai . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/118229

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kiss, Ágnes. “A Candida albicans környezeti stressz indukálta morfológiai változásai .” 2011. Thesis, University of Debrecen. Accessed March 02, 2021. http://hdl.handle.net/2437/118229.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kiss, Ágnes. “A Candida albicans környezeti stressz indukálta morfológiai változásai .” 2011. Web. 02 Mar 2021.

Vancouver:

Kiss �. A Candida albicans környezeti stressz indukálta morfológiai változásai . [Internet] [Thesis]. University of Debrecen; 2011. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2437/118229.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kiss �. A Candida albicans környezeti stressz indukálta morfológiai változásai . [Thesis]. University of Debrecen; 2011. Available from: http://hdl.handle.net/2437/118229

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

6. Borák, Balázs Sándor. Candida albicans Time- lapse imaging képszekvenciáinak digitális képanalízise .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2013, University of Debrecen

URL: http://hdl.handle.net/2437/168010

► Munkánk során két Candida albicans törzs morfológiai sajátságát vizsgáltuk szérum, illetve szérummentes környezetbe. A felvételek a tanszéken dolgozó fiatalok által kifejlesztett sejttenyésztő inkubátorba elhelyezett 4… (more)

Subjects/Keywords: Candida albicans; LTS

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APA (6^th Edition):

Borák, B. S. (2013). Candida albicans Time- lapse imaging képszekvenciáinak digitális képanalízise . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/168010

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Borák, Balázs Sándor. “Candida albicans Time- lapse imaging képszekvenciáinak digitális képanalízise .” 2013. Thesis, University of Debrecen. Accessed March 02, 2021. http://hdl.handle.net/2437/168010.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Borák, Balázs Sándor. “Candida albicans Time- lapse imaging képszekvenciáinak digitális képanalízise .” 2013. Web. 02 Mar 2021.

Vancouver:

Borák BS. Candida albicans Time- lapse imaging képszekvenciáinak digitális képanalízise . [Internet] [Thesis]. University of Debrecen; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2437/168010.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Borák BS. Candida albicans Time- lapse imaging képszekvenciáinak digitális képanalízise . [Thesis]. University of Debrecen; 2013. Available from: http://hdl.handle.net/2437/168010

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

7. Sipos, Lilla. Betametazon hatása a Candida albicans virulenciájára .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2013, University of Debrecen

URL: http://hdl.handle.net/2437/168030

A gyógyászatban általánosan alkalmazott glükokortikoszteroid (betametazon) hatása az opportunista patogén Candida albicans dimorf gomba virulenciájára. Advisors/Committee Members: Pócsi, István (advisor).

Subjects/Keywords: Candida albicans; betametazon

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APA (6^th Edition):

Sipos, L. (2013). Betametazon hatása a Candida albicans virulenciájára . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/168030

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sipos, Lilla. “Betametazon hatása a Candida albicans virulenciájára .” 2013. Thesis, University of Debrecen. Accessed March 02, 2021. http://hdl.handle.net/2437/168030.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sipos, Lilla. “Betametazon hatása a Candida albicans virulenciájára .” 2013. Web. 02 Mar 2021.

Vancouver:

Sipos L. Betametazon hatása a Candida albicans virulenciájára . [Internet] [Thesis]. University of Debrecen; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2437/168030.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sipos L. Betametazon hatása a Candida albicans virulenciájára . [Thesis]. University of Debrecen; 2013. Available from: http://hdl.handle.net/2437/168030

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Aberdeen

8. Ene, Iuliana V. Impact of host carbon sources in the pathobiology of Candida albicans.

Degree: PhD, 2012, University of Aberdeen

URL: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153024260005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558630

► Candida albicans is the most common systemic fungal pathogen of humans. Virulence factors, fitness attributes and the host immunity ultimately determine the ability of C.… (more)

Subjects/Keywords: 610; Candida Albicans

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APA (6^th Edition):

Ene, I. V. (2012). Impact of host carbon sources in the pathobiology of Candida albicans. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153024260005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558630

Chicago Manual of Style (16^th Edition):

Ene, Iuliana V. “Impact of host carbon sources in the pathobiology of Candida albicans.” 2012. Doctoral Dissertation, University of Aberdeen. Accessed March 02, 2021. https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153024260005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558630.

MLA Handbook (7^th Edition):

Ene, Iuliana V. “Impact of host carbon sources in the pathobiology of Candida albicans.” 2012. Web. 02 Mar 2021.

Vancouver:

Ene IV. Impact of host carbon sources in the pathobiology of Candida albicans. [Internet] [Doctoral dissertation]. University of Aberdeen; 2012. [cited 2021 Mar 02]. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153024260005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558630.

Council of Science Editors:

Ene IV. Impact of host carbon sources in the pathobiology of Candida albicans. [Doctoral Dissertation]. University of Aberdeen; 2012. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153024260005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558630

University of Aberdeen

9. Tilliman, Anna Theresa. Nitrosative and combinatorial stress responses in Candida albicans.

Degree: PhD, 2013, University of Aberdeen

URL: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153123490005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569642

► Fungal nitrosative stress responses are understudied and poorly understood. Also, while the responses of the pathogen Candida albicans to individual oxidative and cationic stresses have… (more)

▼ Fungal nitrosative stress responses are understudied and poorly understood. Also, while the responses of the pathogen Candida albicans to individual oxidative and cationic stresses have been characterised relatively well, the responses of this pathogen to simultaneous combinations of these and nitrosative stresses have not been elaborated. Yet, C. albicans is exposed to these combinatorial stresses during disease progression. Therefore, the overall aim of this project was to characterise the "Nitrosative and Combinatorial Stress Responses in Candida albicans". The first objective was to elucidate nitrosative stress response mechanisms in C. albicans at a cellular, transcriptional and post-translational level. Genetic screens revealed that the Hog1 and Mkc1 signalling pathways contribute to nitrosative stress adaptation in addition to Cta4 signalling. The next objective was to characterise responses to combinatorial nitrosative, oxidative and/or cationic stresses with respect to the relevant signal transduction pathways. Unexpectedly, combinatorial stresses did not activate classical nitrosative (Cta4) and oxidative (Cap1) signalling mechanisms. Instead, Hog1 signalling was found to play a significant role in the combinatorial stress adaptation. Dramatic changes in the GSH redox potential were observed in response to both single and combinatorial stresses. Thus, GSH redox regulatory mechanisms were explored in more detail. BLAST searches of the C. albicans genome were performed, revealing genes encoding a putative NADPH-dependent glutathione reductase (Glr1) and a GSH-dependent S-nitrosoglutathione reductase (Fdh3). We confirmed that both conserved enzymes are involved in the maintenance of redox homeostasis and hence are crucial for C. albicans adaptation during host-pathogen interactions. This was achieved by showing that inactivation of Glr1 or Fdh3 disturbs GSH redox homeostasis, confers oxidative and formaldehyde stress sensitivity and attenuates virulence.

Subjects/Keywords: 610; Candida Albicans

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APA (6^th Edition):

Tilliman, A. T. (2013). Nitrosative and combinatorial stress responses in Candida albicans. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153123490005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569642

Chicago Manual of Style (16^th Edition):

Tilliman, Anna Theresa. “Nitrosative and combinatorial stress responses in Candida albicans.” 2013. Doctoral Dissertation, University of Aberdeen. Accessed March 02, 2021. https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153123490005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569642.

MLA Handbook (7^th Edition):

Tilliman, Anna Theresa. “Nitrosative and combinatorial stress responses in Candida albicans.” 2013. Web. 02 Mar 2021.

Vancouver:

Tilliman AT. Nitrosative and combinatorial stress responses in Candida albicans. [Internet] [Doctoral dissertation]. University of Aberdeen; 2013. [cited 2021 Mar 02]. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153123490005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569642.

Council of Science Editors:

Tilliman AT. Nitrosative and combinatorial stress responses in Candida albicans. [Doctoral Dissertation]. University of Aberdeen; 2013. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153123490005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569642

Universidade Estadual de Campinas

10. Gomes, Priscila Nogueira. Bioatividade, bioestrutura e morfologia de biofilmes de Candida spp. desenvolvidos na presença de fluconazol: Bioactivity, biostructure and morphology of Candida spp. biofilms grown in the preence of fluconazole.

Degree: 2011, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/288079

► Abstract: Candida spp. biofilm formed on removable denture surfaces is considered the main etiologic factor of candidosis, being the C. albicans and C.glabrata the species… (more)

▼ Abstract: Candida spp. biofilm formed on removable denture surfaces is considered the main etiologic factor of candidosis, being the C. albicans and C.glabrata the species most frequently found in this condition. The antifungic fluconazol (FLZ) is commonly used in the treatment of candidosis, however its success is limited due to the resistance developed by Candida to this medicament. Considering the importance of the structure and morphology of Candida biofilms in the candidosis, the aim of this study was to evaluate the effect of FLZ on the bioactivity, biostructure and morphology of Candida spp. biofilms formed in the presence of this antifungal agent. Specimens (10 mm x 2 mm) were fabricated using water bath poly(methylmethacrylate) resin (PMMA). Salivary pellicles were formed on the PMMA surface, and biofilms of a reference strain and two clinical isolates of C. albicans (ATCC 90028, P01, P34) and C. glabrata (ATCC 2001, P11, P31) were developed for a period of 48h. Two groups were formed: control and experimental. FLZ at 2.56 µg/mL, concentration bioavailable in saliva, was added to the medium of the experimental group. The culture mediums of the control and experimental groups were changed at 24 hours. The bioactivities of the biofilms were evaluated with XTT reduction colorimetric assay. The biostructure was analyzed by the Confocal Scanning Laser Microscopy and the cell morphology analyzed by the Transmission Electron Microscopy. The data were analyzed by Student's t-test, with significance level set at 5%. The presence of FLZ decreased the bioactivity of all C. albicans biofilms (p<0.001), it did not change the structure and morphology of P34. As regards C. glabrata biofilms bioactivity and biostructure, no statistically significant differences were found between control and experimental groups for biofilms of all strains. It could be concluded that the alterations in bioactivity, biostructure and cell morphology in response to the treatment with fluconazole, bioavailable concentration present in saliva, depends on the Candida spp. strain Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Del Bel Cury, Altair Antoninha, 1948- (advisor), Universidade Estadual de Campinas. Faculdade de Odontologia de Piracicaba (institution), Programa de Pós-Graduação em Clínica Odontológica (nameofprogram), Moyses, Marcos Ribeiro (committee member), Ribeiro, João Gustavo Rabelo (committee member), Cenci, Tatiana Pereira (committee member), Garcia, Renata Cunha Matheus Rodrigues (committee member).

Subjects/Keywords: Candida albicans; Candida glabrata; Candida albicans; Candida glabrata

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gomes, P. N. (2011). Bioatividade, bioestrutura e morfologia de biofilmes de Candida spp. desenvolvidos na presença de fluconazol: Bioactivity, biostructure and morphology of Candida spp. biofilms grown in the preence of fluconazole. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/288079

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gomes, Priscila Nogueira. “Bioatividade, bioestrutura e morfologia de biofilmes de Candida spp. desenvolvidos na presença de fluconazol: Bioactivity, biostructure and morphology of Candida spp. biofilms grown in the preence of fluconazole.” 2011. Thesis, Universidade Estadual de Campinas. Accessed March 02, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288079.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gomes, Priscila Nogueira. “Bioatividade, bioestrutura e morfologia de biofilmes de Candida spp. desenvolvidos na presença de fluconazol: Bioactivity, biostructure and morphology of Candida spp. biofilms grown in the preence of fluconazole.” 2011. Web. 02 Mar 2021.

Vancouver:

Gomes PN. Bioatividade, bioestrutura e morfologia de biofilmes de Candida spp. desenvolvidos na presença de fluconazol: Bioactivity, biostructure and morphology of Candida spp. biofilms grown in the preence of fluconazole. [Internet] [Thesis]. Universidade Estadual de Campinas; 2011. [cited 2021 Mar 02]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/288079.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gomes PN. Bioatividade, bioestrutura e morfologia de biofilmes de Candida spp. desenvolvidos na presença de fluconazol: Bioactivity, biostructure and morphology of Candida spp. biofilms grown in the preence of fluconazole. [Thesis]. Universidade Estadual de Campinas; 2011. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/288079

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

11. Ruy, Fernando. Estudo da bioenergetica mitocondrial de leveduras de importancia patologica : determinação da contribuição das diferentes vias de transporte de eletrons para o crescimento celular: Studies on mitochondrial bioenergetics in pathogenic fungi: determination of the contribution of the contribution of different electron transport pathways toward cell growth.

Degree: 2007, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/313796

► Abstract: Candida albicans is an important pathogen in humans. A crucial feature of this microorganism is its ability to survive in different environments within the… (more)

▼ Abstract: Candida albicans is an important pathogen in humans. A crucial feature of this microorganism is its ability to survive in different environments within the host with distinct oxygen tensions. It is believed that this flexibility is due the expression of alternative oxygen reduction pathways and the control of electron flux between them and the classical respiratory chain. The presence of these pathways may also be related to the high resistance these fungi present to drugs, since the inhibition of one electron transport pathway can be compensated by the activity of the others. In this study we confirm the presence of three electron transport pathways in Candida albicans: the classical respiratory chain (CRC), a parallel chain (PAR) and an alternative oxidase (AOX). We also evaluated the contribution of each pathway toward yeast growth. To do so, we measured cellular proliferation in the absence and presence of electron transport inhibitors. Antimycin A and KCN, which inhibit Complexes III and IV, respectively, totally prevented cellular growth. BHAM, an AOX inhibitor, also promoted inhibition of yeast growth. Surprisingly, the presence of rotenone, an inhibitor of respiratory Complex I, inhibited yeast growth only partially. These results were then correlated with oxygen uptake in mitochondrial and cell suspensions, which revealed that rotenone and BHAM promote only partial respiratory inhibitions. Concentrations of antimycin and KCN which promoted partial respiratory inhibition had distinct effects on growth. While antimycin totally prevented cell proliferation, KCN did not. We also evaluated the levels of reactive species of oxygen (ROS) and oxidized glutathione in the cells incubated in the presence of respiratory inhibitors. The levels of ROS in antimycin-treated cells were significantly higher than in the other groups. Finally, we observed an increase of oxidized glutathione in cells incubated in the presence of antimycin and BHAM. These experimental findings suggest that inhibitions of complex III of the CRC and AOX prevent Candida albicans growth by promoting oxidative stress, indicating the importance of these pathways to ensure yeast viability Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Kowaltowski, Alicia Juliana (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Ciências Médicas (nameofprogram), Cuccovia, Iolanda Midea (committee member), Campos, Claudia Barbosa Ladeira de (committee member), Gadelha, Fernanda Ramos (committee member), Bassani, Rosana Almada (committee member).

Subjects/Keywords: Candida albicans

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ruy, F. (2007). Estudo da bioenergetica mitocondrial de leveduras de importancia patologica : determinação da contribuição das diferentes vias de transporte de eletrons para o crescimento celular: Studies on mitochondrial bioenergetics in pathogenic fungi: determination of the contribution of the contribution of different electron transport pathways toward cell growth. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/313796

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ruy, Fernando. “Estudo da bioenergetica mitocondrial de leveduras de importancia patologica : determinação da contribuição das diferentes vias de transporte de eletrons para o crescimento celular: Studies on mitochondrial bioenergetics in pathogenic fungi: determination of the contribution of the contribution of different electron transport pathways toward cell growth.” 2007. Thesis, Universidade Estadual de Campinas. Accessed March 02, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313796.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ruy, Fernando. “Estudo da bioenergetica mitocondrial de leveduras de importancia patologica : determinação da contribuição das diferentes vias de transporte de eletrons para o crescimento celular: Studies on mitochondrial bioenergetics in pathogenic fungi: determination of the contribution of the contribution of different electron transport pathways toward cell growth.” 2007. Web. 02 Mar 2021.

Vancouver:

Ruy F. Estudo da bioenergetica mitocondrial de leveduras de importancia patologica : determinação da contribuição das diferentes vias de transporte de eletrons para o crescimento celular: Studies on mitochondrial bioenergetics in pathogenic fungi: determination of the contribution of the contribution of different electron transport pathways toward cell growth. [Internet] [Thesis]. Universidade Estadual de Campinas; 2007. [cited 2021 Mar 02]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/313796.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ruy F. Estudo da bioenergetica mitocondrial de leveduras de importancia patologica : determinação da contribuição das diferentes vias de transporte de eletrons para o crescimento celular: Studies on mitochondrial bioenergetics in pathogenic fungi: determination of the contribution of the contribution of different electron transport pathways toward cell growth. [Thesis]. Universidade Estadual de Campinas; 2007. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/313796

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Morgana Ramos Martins Xerez. Fator de necrose tumoral alfa (TNF-α) inibe a formaÃÃo do biofilme de C. albicans.

Degree: Master, 2016, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16602 ;

►

The aim of this study was to investigate the activity of TNF-α against Candida albicans biofilm. Therefore, week biofilm producer (49BMv and 51BMv) and strong… (more)

▼

The aim of this study was to investigate the activity of TNF-α against Candida albicans biofilm. Therefore, week biofilm producer (49BMv and 51BMv) and strong biofilm producer (ATCC 10231 and CEMM 01.05.006) strains of C. albicans were incubated in RPMI medium in 96-well plates at 35 ÂC for 48 or 96 hours in order to assess biofilm formation and mature biofilm, respectively, in the absence or presence of different concentrations of TNF-α (0.1, 0.5, 1, 10, 20 and 40 ng/ml). TNF-α was added during preparation of the biofilm to assess its effect on biofilm formation or after 48 hours of culture for evaluation in mature biofilm. After incubation, the metabolic activity was assessed using XTT reduction assay. The minimum inhibitory concentration (MIC) of TNF-α against C. albicans was evaluated by broth microdilution technique according to Document M27-A3, recommended by CLSI, using the concentrations 0.5, 1, 10 and 20 ng/mL. An analysis of the hyphae/blastoconidia ratio in biofilm was performed using optical microscopy by couting of filamentous (hyphae and pseudo-hyphae) and yeast cells and then a formula which allowed visualization of the relationship between the amount of filamentous and other structures was applied. The results indicated that TNF-α showed a significant inhibition of biofilm formation in a dose-dependent way and a discrete mature biofilm inhibition. In addition, the analysis of hyphae/blastoconidia ratio showed a statistically significant reduction in the number of filamentous forms in biofilm formation in the presence of TNF-α. However, the growth of C. albicans in planktonic form was not affected by any of the TNF-α concentrations used. These results indicate that TNF-α inhibits the formation of C. albicans biofilms, probably through the suppression of filamentation, a crucial step in biofilm formation.

O presente estudo teve como objetivo investigar a aÃÃo do TNF-α frente ao biofilme de Candida albicans. Para tanto, cepas de C. albicans fracamente produtoras de biofilme (49BMv e 51BMv) e fortemente produtoras de biofilme (ATCC 10231 e CEMM 01.05.006) foram incubadas em meio RPMI em placas de 96 poÃos, a 35 ÂC por 48 ou 96 horas para avaliar o desenvolvimento do biofilme em formaÃÃo e maduro, respectivamente, na ausÃncia ou presenÃa de diferentes concentraÃÃes de TNF-α (0,1, 0,5, 1, 10, 20 e 40 ng/mL). A adiÃÃo do TNF-α foi realizada no momento do preparo do cultivo para avaliar seu efeito no biofilme em formaÃÃo ou apÃs 48 horas de cultura para avaliaÃÃo no biofilme maduro. ApÃs incubaÃÃo, a atividade metabÃlica foi avaliada por meio do ensaio de reduÃÃo de XTT. A concentraÃÃo inibitÃria mÃnima (CIM) do TNF-α em C. albicans foi avaliada, dentre as concentraÃÃes testadas 0,5, 1, 10 e 20 ng/mL, por meio da tÃcnica de microdiluiÃÃo em caldo, segundo documento M27-A3, preconizada pelo CLSI. Foi realizada uma anÃlise da relaÃÃo hifas/blastoconÃdios do biofilme por microscopia Ãptica, por meio de uma contagem das formas filamentosas (hifas e…

Advisors/Committee Members: Francisco Airton Castro da Rocha, VirgÃnia ClÃudia Carneiro GirÃo, Marcos FÃbio Gadelha Rocha.

Subjects/Keywords: FARMACIA; Biofilmes; Candida albicans; Hifas

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Xerez, M. R. M. (2016). Fator de necrose tumoral alfa (TNF-α) inibe a formaÃÃo do biofilme de C. albicans. (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16602 ;

Chicago Manual of Style (16^th Edition):

Xerez, Morgana Ramos Martins. “Fator de necrose tumoral alfa (TNF-α) inibe a formaÃÃo do biofilme de C. albicans.” 2016. Masters Thesis, Universidade Federal do Ceará. Accessed March 02, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16602 ;.

MLA Handbook (7^th Edition):

Xerez, Morgana Ramos Martins. “Fator de necrose tumoral alfa (TNF-α) inibe a formaÃÃo do biofilme de C. albicans.” 2016. Web. 02 Mar 2021.

Vancouver:

Xerez MRM. Fator de necrose tumoral alfa (TNF-α) inibe a formaÃÃo do biofilme de C. albicans. [Internet] [Masters thesis]. Universidade Federal do Ceará 2016. [cited 2021 Mar 02]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16602 ;.

Council of Science Editors:

Xerez MRM. Fator de necrose tumoral alfa (TNF-α) inibe a formaÃÃo do biofilme de C. albicans. [Masters Thesis]. Universidade Federal do Ceará 2016. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16602 ;

Université Laval

13. Garcia-Rangel, Carlos-Enrique. Anti-Candida activity of the human gut metabolome.

Degree: 2018, Université Laval

URL: http://hdl.handle.net/20.500.11794/29994

►

L’intestin humain contient une variété de microbes commensaux qui sont représentés par divers organismes appartenant aux trois domaines de la vie où les Eukarya sont… (more)

▼

L’intestin humain contient une variété de microbes commensaux qui sont représentés par divers organismes appartenant aux trois domaines de la vie où les Eukarya sont essentiellement représentés par le règne des champignons. La levure commensale et opportuniste Candida albicans a été identifiée comme étant le champignon le plus commun dans l’intestin des humains sains. Des études récentes soutiennent que malgré leur faible abondance les levures du genre Candida peuvent altérer l'équilibre du microbiote et conduire à des dysbioses ou des pathologies récurrentes comme la maladie de Crohn et les colites ulcéreuses. Il a été démontré que le microbiote commensal joue un rôle essentiel dans la protection de l’intestin contre la colonisation par des bactéries pathogènes et des pathobiontes. Cependant, jusqu'à présent, on ignore si la prolifération ou la pathogénicité de C. albicans peuvent être contrôlées par d'autres microbiotes fécaux. Dans cette étude, nous avons démontré que le métabolome microbien de l'intestin humain exerce une activité antifongique contre C. albicans et d’autres levures qui résident au niveau intestinal. Ces métabolites inhibent plusieurs traits de virulence de C. albicans incluant la filamentation et l'invasion des cellules humaines. De plus, un crible génétique chez C. albicans a suggéré que TOR est la cible moléculaire de la ou des molécules antifongiques du métabolome microbien de l'intestin humain.

The human gut contains a variety of commensal microbes which are composed of diverse organisms that belong to all three domains of life with Eukarya primarily represented by fungi. The commensal / opportunistic yeast Candida albicans has been reported as the most common fungus in the gut of healthy humans. Recent evidences support that, this small fraction can alter the microbiota equilibrium leading to dysbiosis and diseases like inflammatory bowel diseases. It has been demonstrated that commensal microbiota plays a critical role in the protection of the gut against colonization by other bacterial pathogens and pathobionts. However, so far, whether C. albicans overgrowth or pathogenicity are controlled by other fecal microbiota is not known. In this study, we showed that the human microbial gut metabolome (GM) exerts an antifungal activity against different intestinal-resident yeasts including hyphal growth and the invasion of human enterocytes of C. albicans. Furthermore, a genetic screen in C. albicans suggested that TOR is the molecular target of the antifungal molecule(s) of the GM.

Advisors/Committee Members: Sellam, Adnane.

Subjects/Keywords: Intestins – Microbiologie; Candida albicans; Métabolomique

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garcia-Rangel, C. (2018). Anti-Candida activity of the human gut metabolome. (Thesis). Université Laval. Retrieved from http://hdl.handle.net/20.500.11794/29994

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Garcia-Rangel, Carlos-Enrique. “Anti-Candida activity of the human gut metabolome.” 2018. Thesis, Université Laval. Accessed March 02, 2021. http://hdl.handle.net/20.500.11794/29994.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Garcia-Rangel, Carlos-Enrique. “Anti-Candida activity of the human gut metabolome.” 2018. Web. 02 Mar 2021.

Vancouver:

Garcia-Rangel C. Anti-Candida activity of the human gut metabolome. [Internet] [Thesis]. Université Laval; 2018. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/20.500.11794/29994.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Garcia-Rangel C. Anti-Candida activity of the human gut metabolome. [Thesis]. Université Laval; 2018. Available from: http://hdl.handle.net/20.500.11794/29994

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Laval

14. Messier, Céline. Effets des polyphénols de plantes sur la croissance et certains facteurs de virulence de Candida albicans.

Degree: 2011, Université Laval

URL: http://hdl.handle.net/20.500.11794/22712

► Les buts de notre projet étaient d'étudier les effets de certains polyphenols de plantes sur la croissance, la survie, la formation du biofilm et la… (more)

Subjects/Keywords: Candida albicans; Polyphénols végétaux

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Messier, C. (2011). Effets des polyphénols de plantes sur la croissance et certains facteurs de virulence de Candida albicans. (Thesis). Université Laval. Retrieved from http://hdl.handle.net/20.500.11794/22712

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Messier, Céline. “Effets des polyphénols de plantes sur la croissance et certains facteurs de virulence de Candida albicans.” 2011. Thesis, Université Laval. Accessed March 02, 2021. http://hdl.handle.net/20.500.11794/22712.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Messier, Céline. “Effets des polyphénols de plantes sur la croissance et certains facteurs de virulence de Candida albicans.” 2011. Web. 02 Mar 2021.

Vancouver:

Messier C. Effets des polyphénols de plantes sur la croissance et certains facteurs de virulence de Candida albicans. [Internet] [Thesis]. Université Laval; 2011. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/20.500.11794/22712.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Messier C. Effets des polyphénols de plantes sur la croissance et certains facteurs de virulence de Candida albicans. [Thesis]. Université Laval; 2011. Available from: http://hdl.handle.net/20.500.11794/22712

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Laval

15. Belmadani, Amine. Effets de la dermaseptine-S 1 sur la croissance, la transformation, la formation de biofilms et l'expression de certains gènes de virulence de C. albicans.

Degree: 2018, Université Laval

URL: http://hdl.handle.net/20.500.11794/30434

►

C. albicans est un microorganisme opportuniste présent chez plus de 60% de la population. La pathogénicité de C. albicans est contrôlée par le système immunitaire… (more)

▼

C. albicans est un microorganisme opportuniste présent chez plus de 60% de la population. La pathogénicité de C. albicans est contrôlée par le système immunitaire de l’hôte, grâce entre autres aux peptides antimicrobiens (PAMs). Ces PAMs peuvent être de différentes origines. Notre étude a pour but d’évaluer l’effet d’un PAM d’amphibiens, la dermaseptine-S1 (DS1), sur la croissance, la transformation et l’expression de certains gènes de virulence de C. albicans. C. albicans (ATCC-SC5314) a été cultivé en présence ou en absence de la DS1 à 10, 50, et 100 μg/ml, pendant 24 h puis la croissance a été évaluée par un teste de numération cellulaire. Le passage de la forme levure à la forme hyphe a été évalué par microscopie optique et électronique à balayage après culture en présence ou en absence de la DS1 pendant 3 et 6 h à 37°C et ce en présence de 10% de sérum de veau foetal. L’effet de la DS1 sur la formation de biofilm a été évalué par un test MTT et par microscopie électronique à balayage. Enfin, l’expression de certains gènes protéase aspartique sécrétée (Saps 1, 2, 3, 9, 10 et Hwp1) a été évaluée par qRT-PCR. Nous avons montré que la DS1 réduit de façon significative la croissance de C. albicans. La DS1 inhibe le passage de C. albicans de sa forme blastospore à la forme hyphe, ainsi que la formation du biofilm. L’effet de la DS1 sur C. albicans pourrait passer par un contrôle de l’expression de plusieurs gènes impliqués dans la sécrétion d’enzyme protéolytique. En effet, la DS1 diminue de façon significative l’expression des gènes Saps 1, 2, 3, 9 et 10 ainsi que du gène Hwp1. L’ensemble de nos travaux démontre que la DS1 peut contrôler la pathogénicité de C. albicans.

Candida is an opportunistic microorganism present in more than 60% of the population. The pathogenicity of Candida is controlled by the host immune system, such as antimicrobial peptides (AMPs). These PAMs can be of different origins. Our study is to evaluate the effect of an amphibian-isolated antimicrobial peptide, dermaseptin-S1 (DS1) on the growth, transformation and the expression of certain C. albicans virulence genes. C. albicans (ATCC-SC5314) was cultured in the presence or the absence of DS1 at 10, 50, and 100 μg / ml for 24 h and then the growth of yeast was assessed by cell count. The transformation of yeast was evaluated at 3 and 6 h of culture under conditions conducive to transformation (37°C in the presence of 10% of serum) by optical and scanning electron microscopy. Biofilm formation was assessed using a collagen scaffold, after incubation for 30 min at 30°C, with MTT assay and scanning electron microscopy. Finally, the expression of some secreted aspartic protease genes (Saps 1, 2, 3, 9, 10 and Hwp1) was evaluated by qRT-PCR. The results showed that DS1 significantly reduces the growth of C. albicans. This effect is proportional to the concentration of the peptide. This peptide inhibits the passage of C. albicans from the blastospore to the hypha form. The effect of DS1 on C. albicans involves controlling the expression of several…

Advisors/Committee Members: Rouabhia, Mahmoud.

Subjects/Keywords: Candida albicans; Antibiotiques peptidiques; Biofilms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Belmadani, A. (2018). Effets de la dermaseptine-S 1 sur la croissance, la transformation, la formation de biofilms et l'expression de certains gènes de virulence de C. albicans. (Thesis). Université Laval. Retrieved from http://hdl.handle.net/20.500.11794/30434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Belmadani, Amine. “Effets de la dermaseptine-S 1 sur la croissance, la transformation, la formation de biofilms et l'expression de certains gènes de virulence de C. albicans.” 2018. Thesis, Université Laval. Accessed March 02, 2021. http://hdl.handle.net/20.500.11794/30434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Belmadani, Amine. “Effets de la dermaseptine-S 1 sur la croissance, la transformation, la formation de biofilms et l'expression de certains gènes de virulence de C. albicans.” 2018. Web. 02 Mar 2021.

Vancouver:

Belmadani A. Effets de la dermaseptine-S 1 sur la croissance, la transformation, la formation de biofilms et l'expression de certains gènes de virulence de C. albicans. [Internet] [Thesis]. Université Laval; 2018. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/20.500.11794/30434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Belmadani A. Effets de la dermaseptine-S 1 sur la croissance, la transformation, la formation de biofilms et l'expression de certains gènes de virulence de C. albicans. [Thesis]. Université Laval; 2018. Available from: http://hdl.handle.net/20.500.11794/30434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidad de Chile

16. Correa Hernández, Sebastián Adolfo. Preparación de resinas acrílicas cargadas con nanopartículas de cobre y sus propiedades antimicrobianas frente a Candida albicans.

Degree: 2012, Universidad de Chile

URL: http://repositorio.uchile.cl/handle/2250/112937

► INTRODUCCION. La rehabilitación de pacientes desdentados es vital para recuperar las funciones alteradas por la pérdida de las piezas dentarias. Existen distintos métodos de rehabilitación,… (more)

▼ INTRODUCCION. La rehabilitación de pacientes desdentados es vital para recuperar las funciones alteradas por la pérdida de las piezas dentarias. Existen distintos métodos de rehabilitación, siendo el más común la prótesis removible debido principalmente a razones económicas. El uso de estos aparatos produce una serie de alteraciones en la cavidad bucal, entre estas se encuentra la estomatitis asociada a levaduras del género Candida. El microorganismo que se ha detectado con mayor frecuencia en este tipo de lesiones es Candida albicans, por lo que se considera fundamental para el desarrollo de esta patología. Se ha visto que para que esta infección se produzca se debe colonizar en un primer momento la prótesis removible, este sería el primer paso para la generar la infección de la mucosa oral. El tratamiento de este tipo de lesiones puede resultar difícil, particularmente en pacientes con condiciones predisponentes. Por esta razón se deben promover acciones preventivas que eviten que esta se produzca. Actualmente se ha descubierto que nanopartículas metálicas poseen un fuerte efecto antimicrobiano, por lo que se están utilizando actualmente en el área médica con el objetivo de prevenir infecciones. Los metales más utilizados con este fin son el cobre y la plata. En el presente estudio se utilizaron nanopartículas de cobre (CuNPs) para fabricar un nuevo material en base a acrílico para determinar la capacidad de estas CuNPs de inhibir el crecimiento de C. albicans, una levadura comensal de la microbiota oral, analizando el fenómeno en la superficie de los compósitos como en el medio de cultivo en el cual se sumergieron las muestras. METODOS. Se fabricaron muestras de acrílico cargadas con distintas concentraciones de CuNPs. La caracterización de estas se realizó mediante espectroscopía VIS-UV y espectrometría de energía dispersiva. Las muestras de acrílico se sumergieron en caldos de cultivo en los que se sembraron colonias de Candida albicans para evaluar si se detectaba alguna actividad antimicrobiana en relación al control. Se realizó un recuento de unidades formadoras de colonia (UFC) a partir de diluciones del sobrenadante y del eluido desde de la superficie de las muestras. RESULTADOS. No se apreciaron diferencias significativas al comparar el crecimiento de microorganismos en el medio de cultivo. Sin embargo a partir de los eluídos se pudo ver una disminución considerable en el número de UFC obtenidas desde las muestras cargadas con CuNPs y las muestras control. Este efecto fue directamente proporcional a la cantidad de CuNPs presentes en la resina. La actividad antimicrobiana se mantiene con el paso de los días. CONCLUSIONES. Las resinas acrílicas cargadas con CuNPs poseen una marcada actividad antimicrobiana frente a Candida albicans cuando esta entra en contacto con su superficie. Este efecto es directamente proporcional a la cantidad de CuNPs presentes en su composición y es sostenido en el tiempo. Las propiedades presentadas por este material sugieren que podría ser utilizado para la fabricación de…

Subjects/Keywords: Candida albicans; Resinas acrílicas

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Correa Hernández, S. A. (2012). Preparación de resinas acrílicas cargadas con nanopartículas de cobre y sus propiedades antimicrobianas frente a Candida albicans. (Thesis). Universidad de Chile. Retrieved from http://repositorio.uchile.cl/handle/2250/112937

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Correa Hernández, Sebastián Adolfo. “Preparación de resinas acrílicas cargadas con nanopartículas de cobre y sus propiedades antimicrobianas frente a Candida albicans.” 2012. Thesis, Universidad de Chile. Accessed March 02, 2021. http://repositorio.uchile.cl/handle/2250/112937.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Correa Hernández, Sebastián Adolfo. “Preparación de resinas acrílicas cargadas con nanopartículas de cobre y sus propiedades antimicrobianas frente a Candida albicans.” 2012. Web. 02 Mar 2021.

Vancouver:

Correa Hernández SA. Preparación de resinas acrílicas cargadas con nanopartículas de cobre y sus propiedades antimicrobianas frente a Candida albicans. [Internet] [Thesis]. Universidad de Chile; 2012. [cited 2021 Mar 02]. Available from: http://repositorio.uchile.cl/handle/2250/112937.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Correa Hernández SA. Preparación de resinas acrílicas cargadas con nanopartículas de cobre y sus propiedades antimicrobianas frente a Candida albicans. [Thesis]. Universidad de Chile; 2012. Available from: http://repositorio.uchile.cl/handle/2250/112937

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. ESCHER, Silvia Katrine Silva. Bioprospecção de actinobactérias isoladas da rizosfera de Aniba parviflora Syn fragans (Macacaporanga) da Amazônia e avaliação da atividade antimicrobiana .

Degree: 2016, Universidade Federal de Pernambuco

URL: http://repositorio.ufpe.br/handle/123456789/22671

► As Actinobactérias são representantes de um grupo extremamente diverso de bactérias Grampositivas filamentosas com alto conteúdo de citosina e guanina (G+C) no seu DNA que… (more)

▼ As Actinobactérias são representantes de um grupo extremamente diverso de bactérias Grampositivas filamentosas com alto conteúdo de citosina e guanina (G+C) no seu DNA que pertencem à ordem Actinomycetales. Seu metabolismo é extremamente rico e, frequentemente acompanhado pela produção de metabólitos secundários de extrema diversidade química e ação biológica, especialmente antimicrobiana. No presente trabalho foram isoladas actinoboactérias presente na rizosfera de Aniba parviflora Syn A. fragans e avaliado a atividade antimicrobiana do extrato bruto obtido a partir da fermentação submersa em meio M1 e MPE. O potencial antimicrobiano foi avaliado em duas etapas sendo a primeira, por meio da técnica de bloco de gelose frente a micro-organismos de interesse clínico e ambiental, e na segunda etapa, foi realizado a fermentação submersa nos Meio para produção de euromicina (MPE) e MPE modificado (M1), sob agitação contínua por 168h para obtenção dos metabólitos secundários. O líquido fermentado foi testado a cada 24h para avaliação da sua bioatividade pelo método de difusão em disco. Os metabólitos bioativos foram extraídos com os solventes hexano, clorofórmio e acetato de etila a partir do líquido metabólico em pH 2.0, pH 6,5 e pH 9.0. Posteriormente foi determinada a concentração mínima inibitória (CMI) do extrato mais ativo através da técnica de microdiluição em caldo, e também foi realizada a caracterização química preliminar por cromatografia em camada delgada (CCD). Todas as 11 linhagens isoladas foram identificadas através de análise micromorfológica e a partir do RNAr 16S como pertencentes ao gênero Streptomyces. Os isolados MPO4, MPO9, MPO10 e MPO11 não foram selecionadas para obtenção dos metabólitos secundários, pois não apresentaram efeito antagônico contra os micro-organismos teste. Os metabólitos antimicrobianos foram produzidos a partir de 24h da fermentação apresentando halos de inibição variável entre as linhagens. O extrato de hexano obtido em meio M1 apresentou ação fungicida para C. albicans a 78,1 μg/mL e C. krusei a 312,5 μg/mL. Na prospecção química foram identificados metabólitos secundários da classe das xantinas, compostos fenólicos, triterpenos e esteroides, derivados antracênicos e cumarinas. Advisors/Committee Members: AMORIM, Elba Lúcia Cavalcanti de (advisor), http://lattes.cnpq.br/9670603180357733 (advisor).

Subjects/Keywords: Antibiótico; Streptomyces; Amazônia; Candida albicans

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

ESCHER, S. K. S. (2016). Bioprospecção de actinobactérias isoladas da rizosfera de Aniba parviflora Syn fragans (Macacaporanga) da Amazônia e avaliação da atividade antimicrobiana . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/22671

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ESCHER, Silvia Katrine Silva. “Bioprospecção de actinobactérias isoladas da rizosfera de Aniba parviflora Syn fragans (Macacaporanga) da Amazônia e avaliação da atividade antimicrobiana .” 2016. Thesis, Universidade Federal de Pernambuco. Accessed March 02, 2021. http://repositorio.ufpe.br/handle/123456789/22671.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ESCHER, Silvia Katrine Silva. “Bioprospecção de actinobactérias isoladas da rizosfera de Aniba parviflora Syn fragans (Macacaporanga) da Amazônia e avaliação da atividade antimicrobiana .” 2016. Web. 02 Mar 2021.

Vancouver:

ESCHER SKS. Bioprospecção de actinobactérias isoladas da rizosfera de Aniba parviflora Syn fragans (Macacaporanga) da Amazônia e avaliação da atividade antimicrobiana . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2016. [cited 2021 Mar 02]. Available from: http://repositorio.ufpe.br/handle/123456789/22671.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ESCHER SKS. Bioprospecção de actinobactérias isoladas da rizosfera de Aniba parviflora Syn fragans (Macacaporanga) da Amazônia e avaliação da atividade antimicrobiana . [Thesis]. Universidade Federal de Pernambuco; 2016. Available from: http://repositorio.ufpe.br/handle/123456789/22671

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. CAVALCANTI FILHO, José Robson Neves. Isolamento, caracterização e aplicação de metabólitos secundários de folhas de Buchenavia tetraphylla R.A. Howard (Combretaceae: Combretoideae) .

Degree: 2018, Universidade Federal de Pernambuco

URL: https://repositorio.ufpe.br/handle/123456789/32429

► A frequência de infecções fúngicas invasivas devido a fungos patógenos oportunistas aumentou claramente nos últimos anos, sendo Candida albicans responsável por grande parte dos casos.… (more)

▼ A frequência de infecções fúngicas invasivas devido a fungos patógenos oportunistas aumentou claramente nos últimos anos, sendo Candida albicans responsável por grande parte dos casos. Assim, é importante a busca de novas fontes de moléculas bioativas anti-C. albicans. Buchenavia tetraphylla (Combretaceae) é uma espécie neotropical, distribuída desde Cuba ao Rio de Janeiro, sendo uma planta etnomedicinal utilizada por comunidades tradicionais da região Nordeste do Brasil. Neste contexto, o objetivo deste trabalho foi identificar e caracterizar os metabólitos secundários de B. tetraphylla ativos contra isolados clínicos de C. albicans, avaliando os potenciais de anti-virulência. Folhas de B. tetraphylla coletadas em Buíque-PE, foram secas e moídas. O fracionamento do extrato metanólico foi realizado por cromatografia em coluna aberta Sephadex LH-20, apresentou 11 frações. A atividade antimicrobiana foi determinada com uso da fração I pela determinação das Concentrações Mínima Inibitória (CMI) e Mínima Fungicida (CMF) contra a linhagem padrão de C. albicans (UFPEDA1007), e cepas clínicas recentes. Resazurina (0,01%) foi utilizada como indicador do crescimento microbiano. Os valores do CMI e CMF foram satisfatório para todas as linhagens testadas, mesmo tratada com extrato metanólico e com a fração I desse mesmo extrato. As análises de microscopia eletrônica de varredura revelaram, como esperado, que as leveduras sem tratamento apresentaram formas ovais normais com superfícies lisas e possuíam pseudo-hifas, que estão presente característicamente em células patogênicas. Nas células tratadas com o valor do CMI do extrato metanólico foi observado modificações externas das células, apresentando maiores rachaduras e encolhimento da parede celular, certamente devido à perda de volume citosólico, além da inibição da formação de pseudo-hifas. Os micro-organismos testados apresentaram grande potencial de virulência e quando tratados com a fração I apresentou redução nesse potencial. A fração I foi identificada e demonstrou a presença de buchenavianina e seus análogos. Assim, estes resultados estimulam novas pesquisas sobre aspectos farmacológicos e citotóxicos dos extratos e suas frações de B. tetraphylla a fim de apoiar a sua aplicação como agente antimicrobiano. Advisors/Committee Members: CORREIA, Maria Tereza dos Santos (advisor), SILVA, Luís Cláudio Nascimento da (advisor), http://lattes.cnpq.br/7863845087003953 (advisor).

Subjects/Keywords: Candida Albicans; Metanólitos; Caatinga

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

CAVALCANTI FILHO, J. R. N. (2018). Isolamento, caracterização e aplicação de metabólitos secundários de folhas de Buchenavia tetraphylla R.A. Howard (Combretaceae: Combretoideae) . (Doctoral Dissertation). Universidade Federal de Pernambuco. Retrieved from https://repositorio.ufpe.br/handle/123456789/32429

Chicago Manual of Style (16^th Edition):

CAVALCANTI FILHO, José Robson Neves. “Isolamento, caracterização e aplicação de metabólitos secundários de folhas de Buchenavia tetraphylla R.A. Howard (Combretaceae: Combretoideae) .” 2018. Doctoral Dissertation, Universidade Federal de Pernambuco. Accessed March 02, 2021. https://repositorio.ufpe.br/handle/123456789/32429.

MLA Handbook (7^th Edition):

CAVALCANTI FILHO, José Robson Neves. “Isolamento, caracterização e aplicação de metabólitos secundários de folhas de Buchenavia tetraphylla R.A. Howard (Combretaceae: Combretoideae) .” 2018. Web. 02 Mar 2021.

Vancouver:

CAVALCANTI FILHO JRN. Isolamento, caracterização e aplicação de metabólitos secundários de folhas de Buchenavia tetraphylla R.A. Howard (Combretaceae: Combretoideae) . [Internet] [Doctoral dissertation]. Universidade Federal de Pernambuco; 2018. [cited 2021 Mar 02]. Available from: https://repositorio.ufpe.br/handle/123456789/32429.

Council of Science Editors:

CAVALCANTI FILHO JRN. Isolamento, caracterização e aplicação de metabólitos secundários de folhas de Buchenavia tetraphylla R.A. Howard (Combretaceae: Combretoideae) . [Doctoral Dissertation]. Universidade Federal de Pernambuco; 2018. Available from: https://repositorio.ufpe.br/handle/123456789/32429

19. Lucas, José Miguel Fiadeiro. Interação da proteína Blad do tremoço com a membrana plasmática da Candida albicans .

Degree: 2014, Universidade de Aveiro

URL: http://hdl.handle.net/10773/14913

► O objetivo principal do trabalho foi identificar os alvos potenciais de ligação do polipéptido Blad na membrana plasmática de Candida albicans que permitam elucidar o… (more)

▼ O objetivo principal do trabalho foi identificar os alvos potenciais de ligação do polipéptido Blad na membrana plasmática de Candida albicans que permitam elucidar o mecanismo de ação do polipéptido Blad responsável pela sua potente atividade fungicida. O polipéptido Blad é um antifúngico obtido a partir do tremoço de eficácia igual, ou superior, à dos fungicidas de síntese química existentes no mercado. O polipéptido Blad é um produto intermediário estável do catabolismo da β-conglutina, sendo um polipéptido de 20 kDa, composto por 173 aminoácidos, não glicosilado mas fosforilado e faz parte de uma proteína de 210 kDa. Estudos anteriores efetuados com o fungo patogénico modelo, Candida albicans, revelaram que interfere com a estabilidade da membrana plasmática causando disrupção e inatividade metabólica. Por outro lado, ligando-se a estruturas glicosiladas também foi demonstrado que o polipéptido Blad possui atividade de lectina. Com base nisto, testou-se a hipótese do polipéptido Blad se ligar às proteínas glicosiladas da membrana plasmática de C. albicans, e deste modo desencadear um evento molecular/celular na membrana que leve à morte da célula. Na totalidade dos ensaios de imunodeteção do polipéptido Blad na sua ligação às proteínas da membrana plasmática de C. albicans, verificou-se que este se liga a 9 proteínas com massa molecular aproximada de 75 kDa, 50 kDa, 37 kDa (2), 25 kDa (2), 20 kDa, 15 kDa e 10 kDa. No ensaio de imunodetecção do polipéptido Blad, em que as proteínas da membrana plasmática de C. albicans foram desglicosiladas, parece existir alguma evidência que reforça a assunção do polipéptido Blad possuir atividade de lectina. Após ensaio de imunodeteção do polipéptido Blad ligado a proteínas da membrana plasmática de C. albicans, estas foram isoladas e foram identificadas por espectrometria de massa. As proteínas identificadas com possível afinidade de ligação ao polipéptido Blad foram a enolase 1, alcoól desidrogenase 1 e a subunidade beta da ATP sintetase, que são proteínas descritas na literatura como associadas à membrana plasmática de C. albicans, sendo que a sua função nesta localização celular é desconhecida. Não foi possível realizar a análise das glicanas das proteínas associadas à membrana plasmática de C. albicans com afinidade de ligação ao polipéptido Blad, que foram identificadas neste trabalho, devido a limitações experimentais. Devido às limitações dos procedimentos utilizados neste trabalho, deve-se continuar a tentar, através de procedimentos mais sofisticados, a identificação de potenciais alvos de ligação do polipéptido Blad na membrana plasmática de Candida albicans que permitam elucidar o mecanismo de Advisors/Committee Members: Coimbra, Manuel António (advisor), Monteiro, Sara Alexandra Valadas da Silva (advisor).

Subjects/Keywords: Biotecnologia; Polipeptídeos; Fungicidas; Candida albicans

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lucas, J. M. F. (2014). Interação da proteína Blad do tremoço com a membrana plasmática da Candida albicans . (Thesis). Universidade de Aveiro. Retrieved from http://hdl.handle.net/10773/14913

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lucas, José Miguel Fiadeiro. “Interação da proteína Blad do tremoço com a membrana plasmática da Candida albicans .” 2014. Thesis, Universidade de Aveiro. Accessed March 02, 2021. http://hdl.handle.net/10773/14913.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lucas, José Miguel Fiadeiro. “Interação da proteína Blad do tremoço com a membrana plasmática da Candida albicans .” 2014. Web. 02 Mar 2021.

Vancouver:

Lucas JMF. Interação da proteína Blad do tremoço com a membrana plasmática da Candida albicans . [Internet] [Thesis]. Universidade de Aveiro; 2014. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10773/14913.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lucas JMF. Interação da proteína Blad do tremoço com a membrana plasmática da Candida albicans . [Thesis]. Universidade de Aveiro; 2014. Available from: http://hdl.handle.net/10773/14913

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

20. Jakab, Ágnes. Az oxidatív stressz toleráns Candida albicans törzsek élettani vizsgálata .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2011, University of Debrecen

URL: http://hdl.handle.net/2437/105981

► A Candida albicans az emberi szervezetből leggyakrabban izolált opportunista patogén élesztőgomba, melynek központi környezeti stresszválaszát (CESR) vizsgáltuk. A CESR-t klinikai izolátumokból előállított oxidatív stressz toleráns… (more)

▼ A Candida albicans az emberi szervezetből leggyakrabban izolált opportunista patogén élesztőgomba, melynek központi környezeti stresszválaszát (CESR) vizsgáltuk. A CESR-t klinikai izolátumokból előállított oxidatív stressz toleráns Candida albicans mutáns törzseken tanulmányoztuk. Ezen törzsek antioxidáns védelmi rendszere a belső oxidatív stressz miatt folyamatosan indukált. Így a tBOOH toleráns mutánsok lehetőséget nyújtanak, a keresztvédelem tanulmányozására és így a környezeti stresszválasz jelenségének minél szélesebb spektrumon történő vizsgálatára. A kísérletek során az élesztőt mindazon stressz kezeléseknek kitettük, amivel a gazdaszervezetben, illetve a szervezeten kívüli helyeken egyaránt találkozhat. Ennek érdekében a C. albicans törzseket oxidatív, ozmotikus, nehézfém, Unfolded Protein Response-t generáló, sejtfal, sejtmembrán, hő, hideg és pH stressz kezelésnek tettük ki. A növekedési vizsgálatokkor kapott eredmények statisztikai elemzéséhez Pearson- tesztet használtunk. Az eredmények kiértékelése megmutatta, hogy tBOOH toleráns C. albicans mutáns törzsek növekedés változása szignifikánsan kisebb a C. albicans szülői törzsek növekedés változásától. A C. albicans mutáns törzsek jobban tűrték az oxidatív, ozmotikus, nehézfém, Unfolded Protein Response-t generáló, sejtfal, sejtmembrán, hő, hideg és pH stresszt kiváltó ágensek által okozott stresszhatást, a szülői törzsekkel összehasonlítva. Megállapítottuk a vizsgált stressztípusok együttmozgását, mivel szignifikáns, azaz P < 0,1% volt a korreláció. Ezen élettani kísérletsorozattal alátámasztottuk a CESR létezését C. albicans opportunista patogén élesztőnél ugyanis az oxidatív stressz toleráns fenotípus általánosan megnövelte a mutáns törzsek stressztűrését, amely meghaladta a szülői törzsekét. Így a C. albicans ugyanazon szabályzó elemek indukálásával/represszálásával, egyidejűleg és igen hatékonyan tud védekezni a legkülönbözőbb stresszhatásokkal szemben. A CESR meglétének bizonyítása igen nagy áttörést jelenthet a kandidózis elleni hatásos terápia kidolgozásában, antifungális szerek kifejlesztésében. Ugyanis a CESR elemek az antifungális szerek célzott támadáspontjai lehetnek. Advisors/Committee Members: Pócsi, István (advisor).

Subjects/Keywords: Candida albicans; oxidatív stressz

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jakab, �. (2011). Az oxidatív stressz toleráns Candida albicans törzsek élettani vizsgálata . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/105981

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jakab, Ágnes. “Az oxidatív stressz toleráns Candida albicans törzsek élettani vizsgálata .” 2011. Thesis, University of Debrecen. Accessed March 02, 2021. http://hdl.handle.net/2437/105981.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jakab, Ágnes. “Az oxidatív stressz toleráns Candida albicans törzsek élettani vizsgálata .” 2011. Web. 02 Mar 2021.

Vancouver:

Jakab �. Az oxidatív stressz toleráns Candida albicans törzsek élettani vizsgálata . [Internet] [Thesis]. University of Debrecen; 2011. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2437/105981.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jakab �. Az oxidatív stressz toleráns Candida albicans törzsek élettani vizsgálata . [Thesis]. University of Debrecen; 2011. Available from: http://hdl.handle.net/2437/105981

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

21. Nagy, Ádám. Egy gomba specifikus protein foszfatáz vizsgálata .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2012, University of Debrecen

URL: http://hdl.handle.net/2437/128385

Ellenőriztem, hogy a homozigóta mutáns Candida albicans genomjába reintegrálandó intakt CaPPZ1 gént, valamint a CaPPZ1 mögötti szekvenciát tartalmazó pSFS2A vektor alkalmas-e a tervezett menekítési kísérletre. Advisors/Committee Members: Dombrádi, Viktor (advisor).

Subjects/Keywords: Candida albicans; protein foszfatáz

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nagy, �. (2012). Egy gomba specifikus protein foszfatáz vizsgálata . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/128385

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nagy, Ádám. “Egy gomba specifikus protein foszfatáz vizsgálata .” 2012. Thesis, University of Debrecen. Accessed March 02, 2021. http://hdl.handle.net/2437/128385.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nagy, Ádám. “Egy gomba specifikus protein foszfatáz vizsgálata .” 2012. Web. 02 Mar 2021.

Vancouver:

Nagy �. Egy gomba specifikus protein foszfatáz vizsgálata . [Internet] [Thesis]. University of Debrecen; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2437/128385.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nagy �. Egy gomba specifikus protein foszfatáz vizsgálata . [Thesis]. University of Debrecen; 2012. Available from: http://hdl.handle.net/2437/128385

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

22. Sipos, Lilla. Betametazon hatása a Candida albicans virulenciájára .

Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2013, University of Debrecen

URL: http://hdl.handle.net/2437/176657

Subjects/Keywords: Candida; albicans

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APA (6^th Edition):

Sipos, L. (2013). Betametazon hatása a Candida albicans virulenciájára . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/176657

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sipos, Lilla. “Betametazon hatása a Candida albicans virulenciájára .” 2013. Thesis, University of Debrecen. Accessed March 02, 2021. http://hdl.handle.net/2437/176657.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sipos, Lilla. “Betametazon hatása a Candida albicans virulenciájára .” 2013. Web. 02 Mar 2021.

Vancouver:

Sipos L. Betametazon hatása a Candida albicans virulenciájára . [Internet] [Thesis]. University of Debrecen; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2437/176657.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sipos L. Betametazon hatása a Candida albicans virulenciájára . [Thesis]. University of Debrecen; 2013. Available from: http://hdl.handle.net/2437/176657

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Montana State University

23. Li, Ren-Kai. Structural determination and function of a cell wall epitope of Candida albicans.

Degree: PhD, College of Agriculture, 1992, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/6709

Subjects/Keywords: Candida albicans.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Li, R. (1992). Structural determination and function of a cell wall epitope of Candida albicans. (Doctoral Dissertation). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/6709

Chicago Manual of Style (16^th Edition):

Li, Ren-Kai. “Structural determination and function of a cell wall epitope of Candida albicans.” 1992. Doctoral Dissertation, Montana State University. Accessed March 02, 2021. https://scholarworks.montana.edu/xmlui/handle/1/6709.

MLA Handbook (7^th Edition):

Li, Ren-Kai. “Structural determination and function of a cell wall epitope of Candida albicans.” 1992. Web. 02 Mar 2021.

Vancouver:

Li R. Structural determination and function of a cell wall epitope of Candida albicans. [Internet] [Doctoral dissertation]. Montana State University; 1992. [cited 2021 Mar 02]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/6709.

Council of Science Editors:

Li R. Structural determination and function of a cell wall epitope of Candida albicans. [Doctoral Dissertation]. Montana State University; 1992. Available from: https://scholarworks.montana.edu/xmlui/handle/1/6709

Montana State University

24. Hazen, Kevin Clark. Isolation of a germination autoinhibitor produced by Candida albicans.

Degree: PhD, College of Agriculture, 1982, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/3912

Subjects/Keywords: Candida albicans.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hazen, K. C. (1982). Isolation of a germination autoinhibitor produced by Candida albicans. (Doctoral Dissertation). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/3912

Chicago Manual of Style (16^th Edition):

Hazen, Kevin Clark. “Isolation of a germination autoinhibitor produced by Candida albicans.” 1982. Doctoral Dissertation, Montana State University. Accessed March 02, 2021. https://scholarworks.montana.edu/xmlui/handle/1/3912.

MLA Handbook (7^th Edition):

Hazen, Kevin Clark. “Isolation of a germination autoinhibitor produced by Candida albicans.” 1982. Web. 02 Mar 2021.

Vancouver:

Hazen KC. Isolation of a germination autoinhibitor produced by Candida albicans. [Internet] [Doctoral dissertation]. Montana State University; 1982. [cited 2021 Mar 02]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/3912.

Council of Science Editors:

Hazen KC. Isolation of a germination autoinhibitor produced by Candida albicans. [Doctoral Dissertation]. Montana State University; 1982. Available from: https://scholarworks.montana.edu/xmlui/handle/1/3912

Montana State University

25. Glee, Pati Maurene. Molecular genetics of a Candida albicans-specific DNA fragment.

Degree: PhD, College of Agriculture, 1992, Montana State University

URL: https://scholarworks.montana.edu/xmlui/handle/1/7163

Subjects/Keywords: Candida albicans.

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❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Glee, P. M. (1992). Molecular genetics of a Candida albicans-specific DNA fragment. (Doctoral Dissertation). Montana State University. Retrieved from https://scholarworks.montana.edu/xmlui/handle/1/7163

Chicago Manual of Style (16^th Edition):

Glee, Pati Maurene. “Molecular genetics of a Candida albicans-specific DNA fragment.” 1992. Doctoral Dissertation, Montana State University. Accessed March 02, 2021. https://scholarworks.montana.edu/xmlui/handle/1/7163.

MLA Handbook (7^th Edition):

Glee, Pati Maurene. “Molecular genetics of a Candida albicans-specific DNA fragment.” 1992. Web. 02 Mar 2021.

Vancouver:

Glee PM. Molecular genetics of a Candida albicans-specific DNA fragment. [Internet] [Doctoral dissertation]. Montana State University; 1992. [cited 2021 Mar 02]. Available from: https://scholarworks.montana.edu/xmlui/handle/1/7163.

Council of Science Editors:

Glee PM. Molecular genetics of a Candida albicans-specific DNA fragment. [Doctoral Dissertation]. Montana State University; 1992. Available from: https://scholarworks.montana.edu/xmlui/handle/1/7163

University of Aberdeen

26. Leach, Michelle D. Impact of post-translational modifications during stress adaptation in Candida albicans.

Degree: School of Medical Sciences., 2011, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=167804 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=167804&custom_att_2=simple_viewer

Subjects/Keywords: Candida Albicans

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Leach, M. D. (2011). Impact of post-translational modifications during stress adaptation in Candida albicans. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=167804 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=167804&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Leach, Michelle D. “Impact of post-translational modifications during stress adaptation in Candida albicans.” 2011. Doctoral Dissertation, University of Aberdeen. Accessed March 02, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=167804 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=167804&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Leach, Michelle D. “Impact of post-translational modifications during stress adaptation in Candida albicans.” 2011. Web. 02 Mar 2021.

Vancouver:

Leach MD. Impact of post-translational modifications during stress adaptation in Candida albicans. [Internet] [Doctoral dissertation]. University of Aberdeen; 2011. [cited 2021 Mar 02]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=167804 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=167804&custom_att_2=simple_viewer.

Council of Science Editors:

Leach MD. Impact of post-translational modifications during stress adaptation in Candida albicans. [Doctoral Dissertation]. University of Aberdeen; 2011. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=167804 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=167804&custom_att_2=simple_viewer

University of Aberdeen

27. O'Donnell, Raymond William. Chitinolytic enzymes of Candida albicans.

Degree: School of Medical Sciences., 1991, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158392 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158392&custom_att_2=simple_viewer

Subjects/Keywords: Candida Albicans.

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

O'Donnell, R. W. (1991). Chitinolytic enzymes of Candida albicans. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158392 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158392&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

O'Donnell, Raymond William. “Chitinolytic enzymes of Candida albicans.” 1991. Doctoral Dissertation, University of Aberdeen. Accessed March 02, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158392 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158392&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

O'Donnell, Raymond William. “Chitinolytic enzymes of Candida albicans.” 1991. Web. 02 Mar 2021.

Vancouver:

O'Donnell RW. Chitinolytic enzymes of Candida albicans. [Internet] [Doctoral dissertation]. University of Aberdeen; 1991. [cited 2021 Mar 02]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158392 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158392&custom_att_2=simple_viewer.

Council of Science Editors:

O'Donnell RW. Chitinolytic enzymes of Candida albicans. [Doctoral Dissertation]. University of Aberdeen; 1991. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158392 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158392&custom_att_2=simple_viewer

University of Aberdeen

28. Nather, Kerstin. Dynamics and heterogeneity of Candida albicans cell surface proteins.

Degree: Dept. of Molecular and Cell Biology., 2010, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158587 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158587&custom_att_2=simple_viewer

Subjects/Keywords: Candida Albicans.

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nather, K. (2010). Dynamics and heterogeneity of Candida albicans cell surface proteins. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158587 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158587&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Nather, Kerstin. “Dynamics and heterogeneity of Candida albicans cell surface proteins.” 2010. Doctoral Dissertation, University of Aberdeen. Accessed March 02, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158587 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158587&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Nather, Kerstin. “Dynamics and heterogeneity of Candida albicans cell surface proteins.” 2010. Web. 02 Mar 2021.

Vancouver:

Nather K. Dynamics and heterogeneity of Candida albicans cell surface proteins. [Internet] [Doctoral dissertation]. University of Aberdeen; 2010. [cited 2021 Mar 02]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158587 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158587&custom_att_2=simple_viewer.

Council of Science Editors:

Nather K. Dynamics and heterogeneity of Candida albicans cell surface proteins. [Doctoral Dissertation]. University of Aberdeen; 2010. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=158587 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=158587&custom_att_2=simple_viewer

University of Aberdeen

29. Ene, Iuliana V. Impact of host carbon sources in the pathobiology of Candida albicans.

Degree: School of Medical Sciences., 2012, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=189402 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=189402&custom_att_2=simple_viewer

Subjects/Keywords: Candida Albicans

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ene, I. V. (2012). Impact of host carbon sources in the pathobiology of Candida albicans. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=189402 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=189402&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Ene, Iuliana V. “Impact of host carbon sources in the pathobiology of Candida albicans.” 2012. Doctoral Dissertation, University of Aberdeen. Accessed March 02, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=189402 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=189402&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Ene, Iuliana V. “Impact of host carbon sources in the pathobiology of Candida albicans.” 2012. Web. 02 Mar 2021.

Vancouver:

Ene IV. Impact of host carbon sources in the pathobiology of Candida albicans. [Internet] [Doctoral dissertation]. University of Aberdeen; 2012. [cited 2021 Mar 02]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=189402 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=189402&custom_att_2=simple_viewer.

Council of Science Editors:

Ene IV. Impact of host carbon sources in the pathobiology of Candida albicans. [Doctoral Dissertation]. University of Aberdeen; 2012. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=189402 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=189402&custom_att_2=simple_viewer

University of Aberdeen

30. Tillmann, Anna Theresa. Nitrosative and combinatorial stress responses in Candida albicans.

Degree: School of Medical Sciences., 2013, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=192303 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=192303&custom_att_2=simple_viewer

Subjects/Keywords: Candida Albicans.

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tillmann, A. T. (2013). Nitrosative and combinatorial stress responses in Candida albicans. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=192303 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=192303&custom_att_2=simple_viewer

Chicago Manual of Style (16^th Edition):

Tillmann, Anna Theresa. “Nitrosative and combinatorial stress responses in Candida albicans.” 2013. Doctoral Dissertation, University of Aberdeen. Accessed March 02, 2021. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=192303 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=192303&custom_att_2=simple_viewer.

MLA Handbook (7^th Edition):

Tillmann, Anna Theresa. “Nitrosative and combinatorial stress responses in Candida albicans.” 2013. Web. 02 Mar 2021.

Vancouver:

Tillmann AT. Nitrosative and combinatorial stress responses in Candida albicans. [Internet] [Doctoral dissertation]. University of Aberdeen; 2013. [cited 2021 Mar 02]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=192303 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=192303&custom_att_2=simple_viewer.

Council of Science Editors:

Tillmann AT. Nitrosative and combinatorial stress responses in Candida albicans. [Doctoral Dissertation]. University of Aberdeen; 2013. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=192303 ; http://digitool.abdn.ac.uk:1801/webclient/DeliveryManager?pid=192303&custom_att_2=simple_viewer

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Open Access Theses and Dissertations