subject:(Cancer colorectal)

1. Rogers, Charles Ray. Colorectal Cancer Screening and Young African-American Men: Male Role Norms, Knowledge, Attitudes, and Perceptions.

Degree: 2013, Texas Digital Library

URL: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66704

► Of cancers affecting both men and women, colorectal cancer (CRC) is the second leading cancer to kill African Americans in the U.S. Compared to White… (more)

▼ Of cancers affecting both men and women, colorectal cancer (CRC) is the second leading cancer to kill African Americans in the U.S. Compared to White men, African-American men have CRC incidence and mortality rates 20% and 45% higher, respectively. Owing to CRC???s high incidence and younger age at presentation among African-American men, CRC screening (CRCS) is warranted at age 45 rather than 50. Yet, most studies have focused on men older than 45. The findings of these studies suggest that CRC survival is inversely related to early detection, and advocate the continued need for development, testing, and translating prevention interventions into increase screening behavior. Hence, the two-fold purpose of this study was to (1) conduct a systematic review of the professional literature to assess African-American men???s knowledge, beliefs, and behaviors regarding CRCS; and (2) assess the knowledge, attitudes, male role norms, perceptions of subjective norms, and perceptions of barriers associated with CRCS among young adult African-American men (ages 19-45) employing survey research methodology. Utilizing Garrard???s Matrix Method, the systematic literature review synthesized 28 studies examining African-American men's knowledge, beliefs, and behaviors regarding CRCS. Six factors emerged as associated with CRCS intentions and behaviors: previous CRCS, CRC test preference, perceived benefits, perceived barriers, CRC/CRCS knowledge, and physician support/recommendation. In addition, the mean methodological quality score of 10.9 indicated these studies were, overall, of medium quality and suffered from specific flaws. The second component of this study – an on-line survey questionnaire – described the male role norms, knowledge, attitudes, perceived subjective norms, and perceived barriers associated with screening for CRC among a non-random sample of 157 young adult African-American men. Ultimately, family history of cancer, work status, and perceived barriers were the critical factors associated with attitudes in all of our models/analyses. Of these, perceived barriers are the only factors amenable to change through health education efforts. Because this study was narrowly-focused on a specific group of African Americans, it provides a solid basis for developing structured health education interventions to increase young adult African-American men???s intention to screen for CRC. Advisors/Committee Members: Goodson, Patricia (advisor).

Subjects/Keywords: Colorectal Cancer

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APA (6^th Edition):

Rogers, C. R. (2013). Colorectal Cancer Screening and Young African-American Men: Male Role Norms, Knowledge, Attitudes, and Perceptions. (Thesis). Texas Digital Library. Retrieved from http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66704

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rogers, Charles Ray. “Colorectal Cancer Screening and Young African-American Men: Male Role Norms, Knowledge, Attitudes, and Perceptions.” 2013. Thesis, Texas Digital Library. Accessed January 22, 2021. http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66704.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rogers, Charles Ray. “Colorectal Cancer Screening and Young African-American Men: Male Role Norms, Knowledge, Attitudes, and Perceptions.” 2013. Web. 22 Jan 2021.

Vancouver:

Rogers CR. Colorectal Cancer Screening and Young African-American Men: Male Role Norms, Knowledge, Attitudes, and Perceptions. [Internet] [Thesis]. Texas Digital Library; 2013. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66704.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rogers CR. Colorectal Cancer Screening and Young African-American Men: Male Role Norms, Knowledge, Attitudes, and Perceptions. [Thesis]. Texas Digital Library; 2013. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66704

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University

2. McCabe, Eleanor. TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO.

Degree: 2018, Wake Forest University

URL: http://hdl.handle.net/10339/90738

► Colorectal cancer (CRC) is the second leading cause of cancer-related deaths and the fourth most common cancer in the United States. When CRC disseminates into… (more)

Subjects/Keywords: Colorectal Cancer

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APA (6^th Edition):

McCabe, E. (2018). TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/90738

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McCabe, Eleanor. “TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO.” 2018. Thesis, Wake Forest University. Accessed January 22, 2021. http://hdl.handle.net/10339/90738.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McCabe, Eleanor. “TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO.” 2018. Web. 22 Jan 2021.

Vancouver:

McCabe E. TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO. [Internet] [Thesis]. Wake Forest University; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10339/90738.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McCabe E. TARGETED POLYMER NANOPARTICLES FOR THE DETECTION AND TREATMENT OF DISSEMINATED COLORECTAL CANCER IN VIVO. [Thesis]. Wake Forest University; 2018. Available from: http://hdl.handle.net/10339/90738

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

3. Delisle, Megan. Variations in the quality and cost of colorectal cancer care in Manitoba.

Degree: Surgery, 2019, University of Manitoba

URL: http://hdl.handle.net/1993/34132

► Introduction: This thesis examines the quality of colorectal care and its association with healthcare costs. Methods: Quality of colorectal cancer care was assessed based on… (more)

Subjects/Keywords: Colorectal cancer

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APA (6^th Edition):

Delisle, M. (2019). Variations in the quality and cost of colorectal cancer care in Manitoba. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/34132

Chicago Manual of Style (16^th Edition):

Delisle, Megan. “Variations in the quality and cost of colorectal cancer care in Manitoba.” 2019. Masters Thesis, University of Manitoba. Accessed January 22, 2021. http://hdl.handle.net/1993/34132.

MLA Handbook (7^th Edition):

Delisle, Megan. “Variations in the quality and cost of colorectal cancer care in Manitoba.” 2019. Web. 22 Jan 2021.

Vancouver:

Delisle M. Variations in the quality and cost of colorectal cancer care in Manitoba. [Internet] [Masters thesis]. University of Manitoba; 2019. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1993/34132.

Council of Science Editors:

Delisle M. Variations in the quality and cost of colorectal cancer care in Manitoba. [Masters Thesis]. University of Manitoba; 2019. Available from: http://hdl.handle.net/1993/34132

University of Debrecen

4. Chaviv, Sivan. Pharmacology of Current Drugs in Adjuvant Chemotherapy of Colorectal Cancer .

Degree: DE – Általános Orvostudományi Kar, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/194722

► Colorectal cancer continues to be one of the most frequently diagnosed malignancies worldwide. While a curative treatment remains surgical excision, chemotherapy is an important treatment… (more)

Subjects/Keywords: Chemotherapy; Colorectal cancer

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APA (6^th Edition):

Chaviv, S. (2014). Pharmacology of Current Drugs in Adjuvant Chemotherapy of Colorectal Cancer . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/194722

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chaviv, Sivan. “Pharmacology of Current Drugs in Adjuvant Chemotherapy of Colorectal Cancer .” 2014. Thesis, University of Debrecen. Accessed January 22, 2021. http://hdl.handle.net/2437/194722.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chaviv, Sivan. “Pharmacology of Current Drugs in Adjuvant Chemotherapy of Colorectal Cancer .” 2014. Web. 22 Jan 2021.

Vancouver:

Chaviv S. Pharmacology of Current Drugs in Adjuvant Chemotherapy of Colorectal Cancer . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2437/194722.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chaviv S. Pharmacology of Current Drugs in Adjuvant Chemotherapy of Colorectal Cancer . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/194722

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

5. Sturgeon, Julia D. Fish consumption and risk of colorectal cancer.

Degree: MS, Applied Biostatistics and Epidemiology, 2015, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/601425/rec/2826

► The association between fish consumption and risk of colorectal cancer was investigated in a population-based, incidence density case control study from northern Israel, the Molecular… (more)

▼ The association between fish consumption and risk of colorectal cancer was investigated in a population-based, incidence density case control study from northern Israel, the Molecular Epidemiology of Colorectal Cancer study. Food frequency questionnaire data were used from 1,869 cases and 1,777 controls ascertained and recruited between March 31, 1998 and February 14, 2005. Questionnaire data included three specific fish categories: canned tuna, mackerel/salmon/sardines, and cooked/fried fish. Multivariate unconditional logistic regression was used to assess the association between each fish consumption variable and risk of colorectal cancer. After adjusting for age, sex, and ethnicity consumption of canned tuna was associated with reduced risk of colorectal cancer. Participants who consumed canned tuna had an 18% reduced risk of colorectal cancer compared to those who never consumed canned tuna (odds ratio, 0.82; 95% confidence interval, [0.71, 0.94]). Comparing the highest tertile of fish consumption (1+ serving/week) to the lowest tertile of fish consumption (0 servings/month), canned tuna was associated with a 24% reduction of colorectal cancer risk. Adjusting known risk factors and potential confounders, consumption of mackerel/salmon/sardines was associated with a 27% reduced risk of colorectal cancer when comparing the highest and lowest tertiles of consumption (1+ serving/week vs. 0 servings/month). Consumption of cooked/fried fish was not associated with risk of colorectal cancer at any level of consumption. Data from this planned interim analysis suggest that diets characterized by the consumption of canned tuna as well as mackerel, salmon, and sardines are associated with reduced risk of colorectal cancer. Cooked and fried fish consumption was not associated with risk of colorectal cancer. This finding is consistent with animal studies that have examined the association between omega-3 fatty acids and colon tumor growth, indicating that omega-3 fatty acids inhibit colon carcinogenesis. Advisors/Committee Members: Gruber, Stephen B. (Committee Chair), Stern, Mariana C. (Committee Member), Gauderman, William James (Committee Member).

Subjects/Keywords: colorectal cancer; fish

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APA (6^th Edition):

Sturgeon, J. D. (2015). Fish consumption and risk of colorectal cancer. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/601425/rec/2826

Chicago Manual of Style (16^th Edition):

Sturgeon, Julia D. “Fish consumption and risk of colorectal cancer.” 2015. Masters Thesis, University of Southern California. Accessed January 22, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/601425/rec/2826.

MLA Handbook (7^th Edition):

Sturgeon, Julia D. “Fish consumption and risk of colorectal cancer.” 2015. Web. 22 Jan 2021.

Vancouver:

Sturgeon JD. Fish consumption and risk of colorectal cancer. [Internet] [Masters thesis]. University of Southern California; 2015. [cited 2021 Jan 22]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/601425/rec/2826.

Council of Science Editors:

Sturgeon JD. Fish consumption and risk of colorectal cancer. [Masters Thesis]. University of Southern California; 2015. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/601425/rec/2826

University of New South Wales

6. Law, Eleanor. Coping with colorectal cancer: An investigation of stress appraisal, social support and telomere length in colorectal cancer patients and caregivers.

Degree: Clinical School - South Western Sydney, 2018, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/60248 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51037/SOURCE2?view=true

► A diagnosis of colorectal cancer (CRC) and the treatment that follows is associated with considerable stress affecting both the patient and their caregiver. Whilst both… (more)

▼ A diagnosis of colorectal cancer (CRC) and the treatment that follows is associated with considerable stress affecting both the patient and their caregiver. Whilst both patients and caregivers encounter numerous psychological and physical challenges across the duration of the cancer experience, the extent to which these challenges have an impact on both patients and caregivers can vary considerably. Positioned within the theoretical framework of the Transactional Model of Stress and Coping, this dissertation reports on two studies that explore the role of key variables, in accounting for differential outcomes in patients with CRC and their caregivers from a psychological and physiological perspective (through the measurement of telomere length). The first study was a qualitative study (n = 20), which explored patients’ and caregivers’ experiences of social support within a treatment setting and the factors that limit or facilitate such support. The framework method of analysis revealed four themes: the treating team was identified as a source of social support; changes in existing supports were highlighted; different dimensions of support were reported; and evidence of dyadic coping emerged.The second study explored two aims. The first aim was to explore relationships among telomere length, depression and anxiety, perceived social support, cognitive appraisal of health, and coping in patients and caregivers following a diagnosis of CRC (n = 72). No relationship between telomere length and other variables were found. The second aim was to explore whether variables from the Stress and Coping theoretical framework, namely patient/caregiver status, social support, appraisal and coping, would predict anxiety and depression in patients with CRC and their caregivers (n = 102). Hierarchical multiple regression analysis suggested differing results for anxiety and depression. Caregiver status and harm/loss appraisal were the only significant predictors of anxiety, while only harm/loss appraisal was a significant predictor of depression. The findings of the dissertation are discussed in relation to theoretical underpinnings, highlighting avenues for future research, together with possible directions for clinical practice. The dissertation also highlights new knowledge, research limitations and implications that can help improve the understanding of psychosocial outcomes for CRC patients and their caregivers. Advisors/Committee Members: Girgis, Afaf, Clinical School - South Western Sydney, Faculty of Medicine, UNSW, Levesque, Janelle, Clinical School - South Western Sydney, Faculty of Medicine, UNSW, Lambert, Sylvie, Clinical School - South Western Sydney, Faculty of Medicine, UNSW.

Subjects/Keywords: Colorectal cancer; Psychosocial; Cancer

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APA (6^th Edition):

Law, E. (2018). Coping with colorectal cancer: An investigation of stress appraisal, social support and telomere length in colorectal cancer patients and caregivers. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/60248 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51037/SOURCE2?view=true

Chicago Manual of Style (16^th Edition):

Law, Eleanor. “Coping with colorectal cancer: An investigation of stress appraisal, social support and telomere length in colorectal cancer patients and caregivers.” 2018. Doctoral Dissertation, University of New South Wales. Accessed January 22, 2021. http://handle.unsw.edu.au/1959.4/60248 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51037/SOURCE2?view=true.

MLA Handbook (7^th Edition):

Law, Eleanor. “Coping with colorectal cancer: An investigation of stress appraisal, social support and telomere length in colorectal cancer patients and caregivers.” 2018. Web. 22 Jan 2021.

Vancouver:

Law E. Coping with colorectal cancer: An investigation of stress appraisal, social support and telomere length in colorectal cancer patients and caregivers. [Internet] [Doctoral dissertation]. University of New South Wales; 2018. [cited 2021 Jan 22]. Available from: http://handle.unsw.edu.au/1959.4/60248 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51037/SOURCE2?view=true.

Council of Science Editors:

Law E. Coping with colorectal cancer: An investigation of stress appraisal, social support and telomere length in colorectal cancer patients and caregivers. [Doctoral Dissertation]. University of New South Wales; 2018. Available from: http://handle.unsw.edu.au/1959.4/60248 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51037/SOURCE2?view=true

Boston University

7. Patel, Arzoo. Effects of weight change on metachronous adenomatous polyps.

Degree: MS, Physician Assistant Program, 2017, Boston University

URL: http://hdl.handle.net/2144/26939

► BACKGROUND: Numerous epidemiologic studies have identified obesity as a vital risk factor for the development of colorectal cancer (CRC). More recently, obesity has been linked… (more)

Subjects/Keywords: Medicine; Colorectal adenoma; Colorectal adenomatous polyps; Colorectal cancer; Metachronous colorectal cancer; Metachronous colorectal polyps; Recurrent colorectal adenoma

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APA (6^th Edition):

Patel, A. (2017). Effects of weight change on metachronous adenomatous polyps. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/26939

Chicago Manual of Style (16^th Edition):

Patel, Arzoo. “Effects of weight change on metachronous adenomatous polyps.” 2017. Masters Thesis, Boston University. Accessed January 22, 2021. http://hdl.handle.net/2144/26939.

MLA Handbook (7^th Edition):

Patel, Arzoo. “Effects of weight change on metachronous adenomatous polyps.” 2017. Web. 22 Jan 2021.

Vancouver:

Patel A. Effects of weight change on metachronous adenomatous polyps. [Internet] [Masters thesis]. Boston University; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2144/26939.

Council of Science Editors:

Patel A. Effects of weight change on metachronous adenomatous polyps. [Masters Thesis]. Boston University; 2017. Available from: http://hdl.handle.net/2144/26939

University of the Western Cape

8. Fadaka, Adewale Oluwaseun. MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches .

Degree: 2019, University of the Western Cape

URL: http://hdl.handle.net/11394/7161

► Colorectal cancer (CRC) is referred to as cancers that arise in the colon or rectum. Rectal cancer is most often defined as cancers originating within… (more)

Subjects/Keywords: Colorectal cancer; Cancer biomarkers; Cancer; Early detection

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APA (6^th Edition):

Fadaka, A. O. (2019). MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/7161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fadaka, Adewale Oluwaseun. “MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches .” 2019. Thesis, University of the Western Cape. Accessed January 22, 2021. http://hdl.handle.net/11394/7161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fadaka, Adewale Oluwaseun. “MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches .” 2019. Web. 22 Jan 2021.

Vancouver:

Fadaka AO. MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches . [Internet] [Thesis]. University of the Western Cape; 2019. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/11394/7161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fadaka AO. MicroRNAs as predictive biomarkers for diagnosis and prognosis of colorectal cancer using in silico approaches . [Thesis]. University of the Western Cape; 2019. Available from: http://hdl.handle.net/11394/7161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

9. Muilwijk, M. Effect of food components on colon cancer through microbial transformation in the colon.

Degree: 2013, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/273782

► Because the mortaility rates for colorectal cancer are high, it is of importance that research is done so that risks can be reduced. A major… (more)

Subjects/Keywords: Colorectal cancer; microbial transformation; food

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APA (6^th Edition):

Muilwijk, M. (2013). Effect of food components on colon cancer through microbial transformation in the colon. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/273782

Chicago Manual of Style (16^th Edition):

Muilwijk, M. “Effect of food components on colon cancer through microbial transformation in the colon.” 2013. Masters Thesis, Universiteit Utrecht. Accessed January 22, 2021. http://dspace.library.uu.nl:8080/handle/1874/273782.

MLA Handbook (7^th Edition):

Muilwijk, M. “Effect of food components on colon cancer through microbial transformation in the colon.” 2013. Web. 22 Jan 2021.

Vancouver:

Muilwijk M. Effect of food components on colon cancer through microbial transformation in the colon. [Internet] [Masters thesis]. Universiteit Utrecht; 2013. [cited 2021 Jan 22]. Available from: http://dspace.library.uu.nl:8080/handle/1874/273782.

Council of Science Editors:

Muilwijk M. Effect of food components on colon cancer through microbial transformation in the colon. [Masters Thesis]. Universiteit Utrecht; 2013. Available from: http://dspace.library.uu.nl:8080/handle/1874/273782

10. Goranova, Teodora Evgenieva. Genetic analysis of the process of colorectal carcinogenesis : 大腸癌発生過程の遺伝学的解析; ダイチョウガンハッセイカテイノイデンシガクテキカイセキ.

Degree: Nara Institute of Science and Technology / 奈良先端科学技術大学院大学

URL: http://hdl.handle.net/10061/4677

Subjects/Keywords: colorectal cancer

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APA (6^th Edition):

Goranova, T. E. (n.d.). Genetic analysis of the process of colorectal carcinogenesis : 大腸癌発生過程の遺伝学的解析; ダイチョウガンハッセイカテイノイデンシガクテキカイセキ. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/4677

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Goranova, Teodora Evgenieva. “Genetic analysis of the process of colorectal carcinogenesis : 大腸癌発生過程の遺伝学的解析; ダイチョウガンハッセイカテイノイデンシガクテキカイセキ.” Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed January 22, 2021. http://hdl.handle.net/10061/4677.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Goranova, Teodora Evgenieva. “Genetic analysis of the process of colorectal carcinogenesis : 大腸癌発生過程の遺伝学的解析; ダイチョウガンハッセイカテイノイデンシガクテキカイセキ.” Web. 22 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Goranova TE. Genetic analysis of the process of colorectal carcinogenesis : 大腸癌発生過程の遺伝学的解析; ダイチョウガンハッセイカテイノイデンシガクテキカイセキ. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10061/4677.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Goranova TE. Genetic analysis of the process of colorectal carcinogenesis : 大腸癌発生過程の遺伝学的解析; ダイチョウガンハッセイカテイノイデンシガクテキカイセキ. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; Available from: http://hdl.handle.net/10061/4677

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

11. Kitajima, Takahito. Vasohibin-1 Increases the Malignant Potential of Colorectal Cancer and Is a Biomarker of Poor Prognosis.

Degree: 博士(医学), 2017, Mie University / 三重大学

URL: http://hdl.handle.net/10076/14722

►

Background: Vasohibin-1 (VASHI) is related to angiogenesis and poor prognosis in several types of cancers. However, the biological function and clinical significance of VASHI in… (more)

Subjects/Keywords: Colorectal cancer; vasohibin-1; angiogenesis

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APA (6^th Edition):

Kitajima, T. (2017). Vasohibin-1 Increases the Malignant Potential of Colorectal Cancer and Is a Biomarker of Poor Prognosis. (Thesis). Mie University / 三重大学. Retrieved from http://hdl.handle.net/10076/14722

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kitajima, Takahito. “Vasohibin-1 Increases the Malignant Potential of Colorectal Cancer and Is a Biomarker of Poor Prognosis.” 2017. Thesis, Mie University / 三重大学. Accessed January 22, 2021. http://hdl.handle.net/10076/14722.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kitajima, Takahito. “Vasohibin-1 Increases the Malignant Potential of Colorectal Cancer and Is a Biomarker of Poor Prognosis.” 2017. Web. 22 Jan 2021.

Vancouver:

Kitajima T. Vasohibin-1 Increases the Malignant Potential of Colorectal Cancer and Is a Biomarker of Poor Prognosis. [Internet] [Thesis]. Mie University / 三重大学; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10076/14722.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kitajima T. Vasohibin-1 Increases the Malignant Potential of Colorectal Cancer and Is a Biomarker of Poor Prognosis. [Thesis]. Mie University / 三重大学; 2017. Available from: http://hdl.handle.net/10076/14722

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

12. Ebadi, Maryam. Alterations in adipose tissue in colorectal cancer patients.

Degree: MS, Department of Agricultural, Food, and Nutritional Science, 2012, University of Alberta

URL: https://era.library.ualberta.ca/files/pk02cb819

► Mechanisms underlying fat loss in cancer are not well understood. Knowing the types of fat being lost from adipose tissue may help define interventions to… (more)

Subjects/Keywords: Colorectal cancer; Adipose tissue

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APA (6^th Edition):

Ebadi, M. (2012). Alterations in adipose tissue in colorectal cancer patients. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/pk02cb819

Chicago Manual of Style (16^th Edition):

Ebadi, Maryam. “Alterations in adipose tissue in colorectal cancer patients.” 2012. Masters Thesis, University of Alberta. Accessed January 22, 2021. https://era.library.ualberta.ca/files/pk02cb819.

MLA Handbook (7^th Edition):

Ebadi, Maryam. “Alterations in adipose tissue in colorectal cancer patients.” 2012. Web. 22 Jan 2021.

Vancouver:

Ebadi M. Alterations in adipose tissue in colorectal cancer patients. [Internet] [Masters thesis]. University of Alberta; 2012. [cited 2021 Jan 22]. Available from: https://era.library.ualberta.ca/files/pk02cb819.

Council of Science Editors:

Ebadi M. Alterations in adipose tissue in colorectal cancer patients. [Masters Thesis]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/pk02cb819

Penn State University

13. Ashmore, Joseph Henderson. Dietary, Lifestyle, and Genetic Factors Influencing Colorectal Cancer Risk.

Degree: 2013, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/17387

► Cancers of the colon and rectum (colorectum) are complex diseases that form through a combination of both intrinsic (e.g. genetic variation) and extrinsic (e.g. environmental)… (more)

Subjects/Keywords: Colorectal cancer; nutrition; genetics

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APA (6^th Edition):

Ashmore, J. H. (2013). Dietary, Lifestyle, and Genetic Factors Influencing Colorectal Cancer Risk. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/17387

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ashmore, Joseph Henderson. “Dietary, Lifestyle, and Genetic Factors Influencing Colorectal Cancer Risk.” 2013. Thesis, Penn State University. Accessed January 22, 2021. https://submit-etda.libraries.psu.edu/catalog/17387.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ashmore, Joseph Henderson. “Dietary, Lifestyle, and Genetic Factors Influencing Colorectal Cancer Risk.” 2013. Web. 22 Jan 2021.

Vancouver:

Ashmore JH. Dietary, Lifestyle, and Genetic Factors Influencing Colorectal Cancer Risk. [Internet] [Thesis]. Penn State University; 2013. [cited 2021 Jan 22]. Available from: https://submit-etda.libraries.psu.edu/catalog/17387.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ashmore JH. Dietary, Lifestyle, and Genetic Factors Influencing Colorectal Cancer Risk. [Thesis]. Penn State University; 2013. Available from: https://submit-etda.libraries.psu.edu/catalog/17387

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Waterloo

14. Dekker, Heather. Characterising changes in adhesion and enzyme activity related to drug resistance in colon cancer cells.

Degree: 2018, University of Waterloo

URL: http://hdl.handle.net/10012/14278

► Metastatic colorectal cancer is often fatal, and drug resistance to chemotherapeutic agents is one of the primary contributing factors to this lethality. Drug resistance arises… (more)

Subjects/Keywords: drug resistance; colorectal cancer

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APA (6^th Edition):

Dekker, H. (2018). Characterising changes in adhesion and enzyme activity related to drug resistance in colon cancer cells. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/14278

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dekker, Heather. “Characterising changes in adhesion and enzyme activity related to drug resistance in colon cancer cells.” 2018. Thesis, University of Waterloo. Accessed January 22, 2021. http://hdl.handle.net/10012/14278.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dekker, Heather. “Characterising changes in adhesion and enzyme activity related to drug resistance in colon cancer cells.” 2018. Web. 22 Jan 2021.

Vancouver:

Dekker H. Characterising changes in adhesion and enzyme activity related to drug resistance in colon cancer cells. [Internet] [Thesis]. University of Waterloo; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10012/14278.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dekker H. Characterising changes in adhesion and enzyme activity related to drug resistance in colon cancer cells. [Thesis]. University of Waterloo; 2018. Available from: http://hdl.handle.net/10012/14278

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Queens University

15. Hamilton, Leah. The Diagnostic Interval of Colorectal Cancer Patients in Ontario by Degree of Rurality .

Degree: Community Health and Epidemiology, 2015, Queens University

URL: http://hdl.handle.net/1974/13760

► Background: Wait times while moving through the cancer diagnostic process are a public health concern. Rural populations may experience more challenges in accessing cancer care,… (more)

▼ Background: Wait times while moving through the cancer diagnostic process are a public health concern. Rural populations may experience more challenges in accessing cancer care, which could translate into a longer diagnostic interval and represent a healthcare inequity. This project analyzed the association between rurality of residence and the diagnostic interval of colorectal cancer (CRC) patients in Ontario, Canada. Methods: This was a retrospective population-based cohort study. We used administrative databases available through the Institute for Clinical Evaluative Sciences (ICES) to identify incident CRC cases diagnosed from Jan 1, 2007- May 31, 2012. We assigned each patient a rurality score, based on their census subdivision, and calculated the length of their diagnostic interval. We defined the diagnostic interval as the time (in days) between a patient’s first diagnostic-related encounter with the health care system to the CRC diagnosis date. Data linkage through ICES allowed us to describe variations in cancer stage and the diagnostic interval by degree of rurality of patient residence and to analyze associations through multivariable models taking into account potential confounders. Results: Overall, the median diagnostic interval of the CRC cohort was 64 (IQR: 22-159) days and the 90th percentile was 288 days. Patients with stage I CRC had a longer median diagnostic interval than patients with stage IV CRC. Across rurality categories, a significant difference in median diagnostic interval was detected in the stage I stratum only, ranging from 58.5 to 108 days (p=0.0005), but with the most rural group having the shortest diagnostic interval. Results from adjusted multivariable models suggested that patients in mid-ranged rural categories had similar or longer diagnostic intervals compared to patients in the least rural category while patients in the most rural category maintained the shortest diagnostic intervals. Important covariates included age, comorbidities and CRC sub-site. Conclusion: Our results do not support a rurality effect on stage or the diagnostic interval in the hypothesized direction. Estimates of a shorter interval in the most rural category, especially for stage I disease, call for a deeper analysis to better understand care delivery in those areas and patient characteristics that might affect the interval.

Subjects/Keywords: Rural ; Diagnostic Interval ; Colorectal Cancer

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APA (6^th Edition):

Hamilton, L. (2015). The Diagnostic Interval of Colorectal Cancer Patients in Ontario by Degree of Rurality . (Thesis). Queens University. Retrieved from http://hdl.handle.net/1974/13760

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hamilton, Leah. “The Diagnostic Interval of Colorectal Cancer Patients in Ontario by Degree of Rurality .” 2015. Thesis, Queens University. Accessed January 22, 2021. http://hdl.handle.net/1974/13760.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hamilton, Leah. “The Diagnostic Interval of Colorectal Cancer Patients in Ontario by Degree of Rurality .” 2015. Web. 22 Jan 2021.

Vancouver:

Hamilton L. The Diagnostic Interval of Colorectal Cancer Patients in Ontario by Degree of Rurality . [Internet] [Thesis]. Queens University; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1974/13760.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hamilton L. The Diagnostic Interval of Colorectal Cancer Patients in Ontario by Degree of Rurality . [Thesis]. Queens University; 2015. Available from: http://hdl.handle.net/1974/13760

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

16. Oatway, Christina Marie. Modelling colorectal cancer tumourigenesis using intestinal organoids.

Degree: 2018, University of Toronto

URL: http://hdl.handle.net/1807/91546

►

Colorectal cancer is one of the most common cancers leading to death, thus a better understanding of the mechanisms that lead to tumour initiation and… (more)

Subjects/Keywords: colorectal cancer; intestinal organoids; 0306

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APA (6^th Edition):

Oatway, C. M. (2018). Modelling colorectal cancer tumourigenesis using intestinal organoids. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/91546

Chicago Manual of Style (16^th Edition):

Oatway, Christina Marie. “Modelling colorectal cancer tumourigenesis using intestinal organoids.” 2018. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/91546.

MLA Handbook (7^th Edition):

Oatway, Christina Marie. “Modelling colorectal cancer tumourigenesis using intestinal organoids.” 2018. Web. 22 Jan 2021.

Vancouver:

Oatway CM. Modelling colorectal cancer tumourigenesis using intestinal organoids. [Internet] [Masters thesis]. University of Toronto; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/91546.

Council of Science Editors:

Oatway CM. Modelling colorectal cancer tumourigenesis using intestinal organoids. [Masters Thesis]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/91546

University of Otago

17. Volkova , Ekaterina. The link between obesity, colorectal cancer progression and tumour angiogenesis .

Degree: 2011, University of Otago

URL: http://hdl.handle.net/10523/2042

► A link between obesity and risk of colorectal cancer development is strongly supported by epidemiological studies. Several obesity-related factors are implicated in this relationship. Among… (more)

▼ A link between obesity and risk of colorectal cancer development is strongly supported by epidemiological studies. Several obesity-related factors are implicated in this relationship. Among them, insulin resistance, a direct consequence of excess body weight, is considered as one of the most important. However, the role of obesity and related conditions in disease progression and outcome in colorectal cancer patients is not completely clear. This study investigated the contribution of obesity, insulin resistance and inflammation in colorectal cancer progression and patient survival. As a potential mechanism that could mediate the effect of obesity on colorectal cancer outcome, this study focused on tumour angiogenesis and on tumour resistance to chemotherapy. Patient body mass index (BMI), body surface area, as well as circulating markers of obesity, insulin resistance, inflammation (insulin, C-peptide, insulin-like growth factor-1 (IGF-1), C-reactive protein (CRP) and adiponectin) and angiogenesis (angiopoietin-2 (Ang-2), VEGF-A) were analysed in a New Zealand cohort of 344 colorectal cancer patients in relation to each other, to markers of disease progression and to patient survival. The effect of obesity-related and inflammatory factors on one of the main regulators of angiogenesis, hypoxia-inducible factor-1 (HIF-1), in colon cancer and stromal cells was analysed in vitro. Tumour angiogenesis was compared in two groups of colorectal cancer patients with distinct metabolic characteristics using immunohistochemical staining of tumour samples and analysis of angiogenic proteins levels. The effect of insulin and IGF-1 on cellular responses to chemotherapy drugs (5-fluorouracil, oxaliplatin and irinotecan) in colon cancer and endothelial cells was analysed in vitro. In the colorectal cancer patient cohort, serum CRP and Ang-2, but not other markers, were associated with more advanced tumour characteristics and with worse patient survival. The immunohistochemical analysis of tumour samples showed no difference in tumour angiogenesis between colorectal cancer patients with different metabolic profiles. However, the results suggested that obesity-related factors may contribute to regulation of angiogenic pathways, and this was confirmed in vitro and in tumour tissue protein extracts. Finally, insulin and IGF-1 were shown to modulate the in vitro cellular response to chemotherapy drugs in colon cancer and endothelial cells. Advisors/Committee Members: Currie, Margaret (advisor).

Subjects/Keywords: tumour angiogenesis; colorectal cancer; obesity

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APA (6^th Edition):

Volkova , E. (2011). The link between obesity, colorectal cancer progression and tumour angiogenesis . (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/2042

Chicago Manual of Style (16^th Edition):

Volkova , Ekaterina. “The link between obesity, colorectal cancer progression and tumour angiogenesis .” 2011. Doctoral Dissertation, University of Otago. Accessed January 22, 2021. http://hdl.handle.net/10523/2042.

MLA Handbook (7^th Edition):

Volkova , Ekaterina. “The link between obesity, colorectal cancer progression and tumour angiogenesis .” 2011. Web. 22 Jan 2021.

Vancouver:

Volkova E. The link between obesity, colorectal cancer progression and tumour angiogenesis . [Internet] [Doctoral dissertation]. University of Otago; 2011. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/10523/2042.

Council of Science Editors:

Volkova E. The link between obesity, colorectal cancer progression and tumour angiogenesis . [Doctoral Dissertation]. University of Otago; 2011. Available from: http://hdl.handle.net/10523/2042

University of Guelph

18. Kondra, Roman. Characterizing the Role of Nkd1 in Colorectal Cancer.

Degree: MS, Department of Molecular and Cellular Biology, 2015, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8682

► The Wnt signaling pathway is a highly conserved pathway critical for development and homeostasis of stem cells. Aberrant Wnt signaling causes developmental defects and disease.… (more)

Subjects/Keywords: Wnt; Colorectal Cancer; Nkd1

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APA (6^th Edition):

Kondra, R. (2015). Characterizing the Role of Nkd1 in Colorectal Cancer. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8682

Chicago Manual of Style (16^th Edition):

Kondra, Roman. “Characterizing the Role of Nkd1 in Colorectal Cancer.” 2015. Masters Thesis, University of Guelph. Accessed January 22, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8682.

MLA Handbook (7^th Edition):

Kondra, Roman. “Characterizing the Role of Nkd1 in Colorectal Cancer.” 2015. Web. 22 Jan 2021.

Vancouver:

Kondra R. Characterizing the Role of Nkd1 in Colorectal Cancer. [Internet] [Masters thesis]. University of Guelph; 2015. [cited 2021 Jan 22]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8682.

Council of Science Editors:

Kondra R. Characterizing the Role of Nkd1 in Colorectal Cancer. [Masters Thesis]. University of Guelph; 2015. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8682

19. Abdelhady, Rasha. Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue.

Degree: 2018, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:313114

► Colorectal cancer is the third most commonly diagnosed cancer worldwide. The positive association between red and/or processed meat consumption and human colorectal cancer risk is… (more)

▼ Colorectal cancer is the third most commonly diagnosed cancer worldwide. The positive association between red and/or processed meat consumption and human colorectal cancer risk is well established potentially via heme-catalysed formation of carcinogenic N-nitrosocompounds (NNOC). These NNOC can form a range of O6- alkylguanine (O6-alkylG) adducts that may increase mutational and cancer risk. The overall aim of this study was to develop a novel approach to characterize the overall load of O6-alkylG adducts in human colorectal DNA using the known action of the DNA repair protein, O6-alkylguanine O6-alkyltransferase (MGMT) to irreversibly transfer the alkyl group from O6-alkylG to the MGMT active site peptide (MGMT-ASP). Incubation of chemically synthesised single (SS) and double stranded (DS) oligodeoxyribonucleotides (ODNs) containing O6-methylguanine (O6-MeG), O6- carboxyethylguanine (O6-CEG), but only DS O6-carboxymethylguanine (O6-CMG) -23 mer containing ODNs with MGMT resulted in MGMT inactivation. There was a preference for repair of DS ODNs. Recorded IC50 values were 0.17+0.02, 0.07+0.01, 15.7+2.1, 27.00+1.70 and 7.50+0.50 nanomolar (nM) for SS O6-MeG, DS O6-MeG, DS O6-CMG, SS O6-CEG, and DS O6-CEG, respectively. This repair was confirmed using a restriction endonuclease site deprotection assay as O6-MeG and O6-CEG inhibition of PstI digestion of ODNs, whilst, O6-CMG inhibited MboI. This inhibition was removed by pre-incubation with MGMT. Alkyl group transfer from these ODNs to a Maltose binding protein-MGMT (MBP-MGMT) fusion protein was demonstrated as alkylated active site peptides (ASPs) were detected using with Matrix assisted laser desorption/ionizationtime of flight (MALDI-TOF). S-methylcysteine (m/z 1329.7), and S-carboxyethylcysteine (m/z 1387.7) modified ASPs were detected following incubation of MBP-MGMT incubated with SS or DS O6-MeG, and O6-CEG ODNs, respectively. Scarboxymethylcysteine (m/z 1373.7) was detected with DS but not SS O6-CMG 23 mer ODN. Only the unmodified MGMT-ASP (m/z 1315.7) was found after incubating MGMT with unmodified ODN. Quantitative mass spectrometry (MS) findings highlighted that MGMT preferentially repaired specified adducts when presented in DS ODNs over SS ones. Temozolomide (TMZ) methylated calf thymus DNA (CT-DNA) and human colorectal cancer DNA samples were incubated with his tagged MGMT fusion protein (his-MGMT) and his-MGMT recovered using Ni-coated beads, digested in situ with trypsin and analysed by MALDI-TOF. MS analysis of tryptic digests of MGMT incubated with methylated CT-DNA revealed methylated MGMT-ASP, detecting as low as 50 fmole of O6-MeG/mg CT-DNA. This approach was applied to 13 human colorectal DNA samples, 12 of them showed evidence of O6 alkylation damage. Of 13 samples, 12 contained O6-MeG, 8 contained O6-CMG and 1 contained O6-HOEtG. A further 7 peaks were detected with a signal/noise (S/N) ratio of >10, potentially, correspond to alkylated MGMT-ASP ions but identities of the alkyl groups are as yet unknown. These results demonstrate proof of… Advisors/Committee Members: BARRAN, PERDITA P, Povey, Andrew, Barran, Perdita.

Subjects/Keywords: Colorectal cancer; O6-alkylguanine adducts

10 more images…

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APA (6^th Edition):

Abdelhady, R. (2018). Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:313114

Chicago Manual of Style (16^th Edition):

Abdelhady, Rasha. “Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue.” 2018. Doctoral Dissertation, University of Manchester. Accessed January 22, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:313114.

MLA Handbook (7^th Edition):

Abdelhady, Rasha. “Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue.” 2018. Web. 22 Jan 2021.

Vancouver:

Abdelhady R. Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2021 Jan 22]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:313114.

Council of Science Editors:

Abdelhady R. Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue. [Doctoral Dissertation]. University of Manchester; 2018. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:313114

University of Toronto

20. Wang, Charlie Shihn Kaai. Health Utilization Patterns of Colonic Stents in Colorectal Cancer: A Retrospective Population-based Cohort Analysis.

Degree: 2010, University of Toronto

URL: http://hdl.handle.net/1807/25502

►

Introduction: This study describes the patterns of use and processes of care following colonic stent insertion for patients with colorectal cancer (CRC) in clinical practice.… (more)

Subjects/Keywords: Colorectal cancer; Stent; Obstruction; 0564

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APA (6^th Edition):

Wang, C. S. K. (2010). Health Utilization Patterns of Colonic Stents in Colorectal Cancer: A Retrospective Population-based Cohort Analysis. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/25502

Chicago Manual of Style (16^th Edition):

Wang, Charlie Shihn Kaai. “Health Utilization Patterns of Colonic Stents in Colorectal Cancer: A Retrospective Population-based Cohort Analysis.” 2010. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/25502.

MLA Handbook (7^th Edition):

Wang, Charlie Shihn Kaai. “Health Utilization Patterns of Colonic Stents in Colorectal Cancer: A Retrospective Population-based Cohort Analysis.” 2010. Web. 22 Jan 2021.

Vancouver:

Wang CSK. Health Utilization Patterns of Colonic Stents in Colorectal Cancer: A Retrospective Population-based Cohort Analysis. [Internet] [Masters thesis]. University of Toronto; 2010. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/25502.

Council of Science Editors:

Wang CSK. Health Utilization Patterns of Colonic Stents in Colorectal Cancer: A Retrospective Population-based Cohort Analysis. [Masters Thesis]. University of Toronto; 2010. Available from: http://hdl.handle.net/1807/25502

University of Toronto

21. Fung, Thomas Anthony. Characterizing effects of small molecule inhibition of WDR5 in colorectal cancer.

Degree: 2017, University of Toronto

URL: http://hdl.handle.net/1807/79378

►

Abstract WDR5 is a core subunit of the MLL-WRAD methyltransferases, NSL-MOF acetyltransferases and MYC-MAX transcription factors. Dysregulation of these complexes has been implicated in numerous… (more)

Subjects/Keywords: Colorectal Cancer; Epigenetics; WDR5; 0307

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APA (6^th Edition):

Fung, T. A. (2017). Characterizing effects of small molecule inhibition of WDR5 in colorectal cancer. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/79378

Chicago Manual of Style (16^th Edition):

Fung, Thomas Anthony. “Characterizing effects of small molecule inhibition of WDR5 in colorectal cancer.” 2017. Masters Thesis, University of Toronto. Accessed January 22, 2021. http://hdl.handle.net/1807/79378.

MLA Handbook (7^th Edition):

Fung, Thomas Anthony. “Characterizing effects of small molecule inhibition of WDR5 in colorectal cancer.” 2017. Web. 22 Jan 2021.

Vancouver:

Fung TA. Characterizing effects of small molecule inhibition of WDR5 in colorectal cancer. [Internet] [Masters thesis]. University of Toronto; 2017. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1807/79378.

Council of Science Editors:

Fung TA. Characterizing effects of small molecule inhibition of WDR5 in colorectal cancer. [Masters Thesis]. University of Toronto; 2017. Available from: http://hdl.handle.net/1807/79378

University of Adelaide

22. Arentz, Georgia. Proteomic and molecular analysis in colorectal cancer: validation of the biomarkers desmin, SET and CK8.

Degree: 2010, University of Adelaide

URL: http://hdl.handle.net/2440/63424

► There is potential for significant improvements to be made in the diagnosis, staging, treatment and monitoring of colorectal cancer (CRC). The elucidation of proteins and… (more)

▼ There is potential for significant improvements to be made in the diagnosis, staging, treatment and monitoring of colorectal cancer (CRC). The elucidation of proteins and pathways involved in CRC would aid in the development of biomarkers for detection, identify patients at risk of relapse and potentially give rise to new molecular targets of treatment. Laser microdissectio (LMD) was used with minimal labelling two-dimensional gel electrophoresis (2D DIGE) and mass spectrometry to identify proteins significantly increased in eight early stage paired tumour-normal tissues. Seventeen individual proteins were identified as upregulated by >2 fold (P<0.05). The role of the proteins cytokeratin 8 (CK8) and SET in CRC were chosen for further analysis. A third protein, desmin, was chosen from a pilot study performed using LMD and saturation labelling 2D DIGE for further analysis. The protein desmin was identified as significantly upregulated in a pilot study that aimed to identify proteins with altered expression in the cancerous epithelium and surrounding microenvironment. Using immunofluorescence (IF), desmin expression levels in the tissue stroma of late stage tumours compared to early stage tumours was significantly increased, P<0.0001. The desmin expressing cells were identified to be pericytes, formed around mature vasculature as a result of angiogenic stimulation. From this work desmin appears to have potential use as a histopathology marker for the identification of late stage patients and may help identify patients who would not benefit from the current anti-angiogenic therapies due to the presence of mature tumour microvasculature. Three isoforms of CK8 were found to be upregulated in the DIGE study, with each isoform containing the phosphoserine (PS) residues 23, 431 and 73. Western blotting showed significantly increased phosphorylation levels at these sites in tumour compared to normal tissues. The MAP kinase ERK is known to phosphorylate the 73 and 431 residues and 50% of CRC patients have mutations in the EGFR/Ras/Raf/MEK/ERK signalling pathway (KRAS or BRAF mutations) resulting in constitutive ERK activation. Inhibition of EGFR activation in Caco2 cells showed a significant decrease (P<0.0001) in PS73 and PS431 levels by 59% and 65% respectively, indicating that patients with KRAS or BRAF mutations may have significantly increased PS73 and PS431 levels. Previously it has been shown that high levels of CK8 phosphorylation may help to protect cells against caspase degradation and evasion of apoptosis. This is the first report of the differential expression of phospho-CK8 isoforms in CRC. SET is a known inhibitor of the tumour suppressor PP2A, a component of the GSK3 β complex that targets β catenin for degradation in the Wnt signalling pathway. Ninety percent of CRC patients have Wnt signalling pathway mutations resulting in constitutive pathway activation. The effect of knocking down SET via siRNA on β catenin levels was analysed in SW480 with constitutive Wnt signalling and HEK293 with low levels of Wnt… Advisors/Committee Members: Hardingham, Jennifer E. (advisor), Chataway, Timothy K. (advisor), School of Molecular and Biomedical Science (school).

Subjects/Keywords: proteomics; colorectal cancer; biomarkers

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APA (6^th Edition):

Arentz, G. (2010). Proteomic and molecular analysis in colorectal cancer: validation of the biomarkers desmin, SET and CK8. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/63424

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Arentz, Georgia. “Proteomic and molecular analysis in colorectal cancer: validation of the biomarkers desmin, SET and CK8.” 2010. Thesis, University of Adelaide. Accessed January 22, 2021. http://hdl.handle.net/2440/63424.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Arentz, Georgia. “Proteomic and molecular analysis in colorectal cancer: validation of the biomarkers desmin, SET and CK8.” 2010. Web. 22 Jan 2021.

Vancouver:

Arentz G. Proteomic and molecular analysis in colorectal cancer: validation of the biomarkers desmin, SET and CK8. [Internet] [Thesis]. University of Adelaide; 2010. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2440/63424.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Arentz G. Proteomic and molecular analysis in colorectal cancer: validation of the biomarkers desmin, SET and CK8. [Thesis]. University of Adelaide; 2010. Available from: http://hdl.handle.net/2440/63424

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

23. Helewa, Ramzi M. Does geography influence the treatment and outcomes of colorectal cancer in the province of Manitoba?.

Degree: Surgery, 2012, University of Manitoba

URL: http://hdl.handle.net/1993/8151

► Background: Colorectal cancer (CRC) is the third most common cancer in Manitoba. We sought to determine if regional differences exist for treatments, wait times, and… (more)

Subjects/Keywords: colorectal cancer; quality; geography

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APA (6^th Edition):

Helewa, R. M. (2012). Does geography influence the treatment and outcomes of colorectal cancer in the province of Manitoba?. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/8151

Chicago Manual of Style (16^th Edition):

Helewa, Ramzi M. “Does geography influence the treatment and outcomes of colorectal cancer in the province of Manitoba?.” 2012. Masters Thesis, University of Manitoba. Accessed January 22, 2021. http://hdl.handle.net/1993/8151.

MLA Handbook (7^th Edition):

Helewa, Ramzi M. “Does geography influence the treatment and outcomes of colorectal cancer in the province of Manitoba?.” 2012. Web. 22 Jan 2021.

Vancouver:

Helewa RM. Does geography influence the treatment and outcomes of colorectal cancer in the province of Manitoba?. [Internet] [Masters thesis]. University of Manitoba; 2012. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1993/8151.

Council of Science Editors:

Helewa RM. Does geography influence the treatment and outcomes of colorectal cancer in the province of Manitoba?. [Masters Thesis]. University of Manitoba; 2012. Available from: http://hdl.handle.net/1993/8151

Harvard University

24. Enogieru, Imarhia. The Association of a Colorectal Cancer Screening Patient Navigation Program With Adherence to Timely Surveillance Colonoscopies.

Degree: Doctor of Medicine, 2018, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973510

►

Purpose: Reduction in incidence and mortality of colorectal cancer (CRC) has been attributed to colonoscopy for detection and removal of precursor lesions/polyps. Post-polypectomy patients are… (more)

▼

Purpose: Reduction in incidence and mortality of colorectal cancer (CRC) has been attributed to colonoscopy for detection and removal of precursor lesions/polyps. Post-polypectomy patients are often at higher risk of developing cancer and require follow-up surveillance colonoscopy (FSC). Patient navigation (PN) has been effective in improving screening in low income and minority populations; however, the literature is scarce on its effect on timely FSC. Our objectives were to compare the proportions of timely FSCs in patients who had received PN for initial colonoscopy to patients without PN and to identify reasons for non-adherence with FSC in underserved populations. Methods: In this retrospective, matched cohort study, we reviewed the charts of Massachusetts General Hospital (MGH) Chelsea health center primary care patients who received PN at their initial colonoscopy between 2010-2011 and had abnormal finding requiring surveillance. These patients were matched in a 1:3 ratio by age, gender, race, language and CRC risk category to patients with an abnormal colonoscopy during the same period who required FSC, but were not navigated. The primary outcome was proportion of timely FSC, defined as colonoscopy completed within six months of the recommended date based on the CRC risk score, in navigated vs. non-navigated group. We used a chi-square test for unadjusted comparison and multivariable logistic regression with adjustment for health insurance, education and prior number of annual visits. Our secondary outcome were reasons for non-adherence to timely completion of FSC. Results: Among 216 patients, 34 (55%) who received PN, completed a timely FSC compared to 82 (53%) in the control group (p=0.881). After adjusting for insurance, education, language and number of annual primary care visits, patients who received PN had similar odds (AOR=1.209, 95% CI 0.622-2.349) of completing a timely surveillance when compared to those who did not receive PN. The reasons for non-adherence with timely FSC were related to patients’ issues: declined, moved/traveled, co-morbidities and death. System and provider barriers included: patient referred but scheduling issues, provider miscommunication and delayed referral. Conclusions: Navigation in under served patients for initial colonoscopy did not improve odds of timely FSC. Understanding the multiple reasons for non-adherence could guide future initiatives to improve FSC rates in this population.

Scholarly Project

Subjects/Keywords: Colorectal Cancer; Patient Navigation

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APA (6^th Edition):

Enogieru, I. (2018). The Association of a Colorectal Cancer Screening Patient Navigation Program With Adherence to Timely Surveillance Colonoscopies. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973510

Chicago Manual of Style (16^th Edition):

Enogieru, Imarhia. “The Association of a Colorectal Cancer Screening Patient Navigation Program With Adherence to Timely Surveillance Colonoscopies.” 2018. Doctoral Dissertation, Harvard University. Accessed January 22, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973510.

MLA Handbook (7^th Edition):

Enogieru, Imarhia. “The Association of a Colorectal Cancer Screening Patient Navigation Program With Adherence to Timely Surveillance Colonoscopies.” 2018. Web. 22 Jan 2021.

Vancouver:

Enogieru I. The Association of a Colorectal Cancer Screening Patient Navigation Program With Adherence to Timely Surveillance Colonoscopies. [Internet] [Doctoral dissertation]. Harvard University; 2018. [cited 2021 Jan 22]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973510.

Council of Science Editors:

Enogieru I. The Association of a Colorectal Cancer Screening Patient Navigation Program With Adherence to Timely Surveillance Colonoscopies. [Doctoral Dissertation]. Harvard University; 2018. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973510

Queen Mary, University of London

25. Nijhuis, Anke. Roles of microRNAs in diseases of the human gastrointestinal tract.

Degree: PhD, 2015, Queen Mary, University of London

URL: http://qmro.qmul.ac.uk/xmlui/handle/123456789/9547 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674914

► Crohn's disease (CD) and colorectal cancer (CRC) are major disorders of the intestine. Inflammation in CD often precedes fibrosis and stricture formation, and is linked… (more)

▼ Crohn's disease (CD) and colorectal cancer (CRC) are major disorders of the intestine. Inflammation in CD often precedes fibrosis and stricture formation, and is linked to increased cancer risk. Hypoxia is a common feature of inflammation and CRC that can severely compromise the effectiveness of current therapy regimes including chemo-radiotherapy and maintenance of remission in CD patients. MicroRNAs (miRNAs) are key regulatory molecules involved in cellular proliferation, apoptosis and fibrosis, which are all modulated by hypoxia. This thesis aims to understand the role of miRNAs in these two intestinal diseases. Microarray profiling identified differentially expressed miRNA in the intestinal mucosa overlying strictured and non-strictured CD tissue samples and in six CRC cell lines cultured in hypoxic conditions compared to normoxia. Validation experiments using qRT-PCR confirmed the differential expression of miR-29a, -29b, -29c, -34a, -493* and -708 in CD mucosa and miR-21, -210, -30d, -320a, -320b and -320c in CRC cell lines. Functionally, over-expression of miR-29b in CD intestinal fibroblasts modulated the down-regulation of collagen I and III transcripts and collagen III protein in a TGF-β-dependent manner. Furthermore, miR-29b induced indirectly the expression of the anti-apoptotic protein Mcl-1 via the cytokines IL-6 and IL-8. A positive correlation between miR-210 and the hypoxia marker CAIX was found in CRC tissue in vivo. Furthermore, HCT116 cells cultured under hypoxia were more resistant to the chemotherapy drug 5-FU than cells grown under normoxia. Knockdown of miR-21 or miR-30d under hypoxia may sensitise CRC cells to 5-FU. CRC cell lines grown under hypoxic conditions present an altered cellular metabolic profile compared to their normoxic counterparts. This thesis has showed that critical miRNAs have a functional role in the progression of two important diseases of the intestine. The work presented highlights the potential of miRNAs as biomarkers and therapeutic targets to improve the clinical management of patients with digestive diseases.

Subjects/Keywords: 616.3; Colorectal Cancer; Crohn's disease

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APA (6^th Edition):

Nijhuis, A. (2015). Roles of microRNAs in diseases of the human gastrointestinal tract. (Doctoral Dissertation). Queen Mary, University of London. Retrieved from http://qmro.qmul.ac.uk/xmlui/handle/123456789/9547 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674914

Chicago Manual of Style (16^th Edition):

Nijhuis, Anke. “Roles of microRNAs in diseases of the human gastrointestinal tract.” 2015. Doctoral Dissertation, Queen Mary, University of London. Accessed January 22, 2021. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9547 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674914.

MLA Handbook (7^th Edition):

Nijhuis, Anke. “Roles of microRNAs in diseases of the human gastrointestinal tract.” 2015. Web. 22 Jan 2021.

Vancouver:

Nijhuis A. Roles of microRNAs in diseases of the human gastrointestinal tract. [Internet] [Doctoral dissertation]. Queen Mary, University of London; 2015. [cited 2021 Jan 22]. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/9547 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674914.

Council of Science Editors:

Nijhuis A. Roles of microRNAs in diseases of the human gastrointestinal tract. [Doctoral Dissertation]. Queen Mary, University of London; 2015. Available from: http://qmro.qmul.ac.uk/xmlui/handle/123456789/9547 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.674914

University of Oxford

26. Franklin, James Michael. Imaging biomarkers for oligometastatic colorectal cancer.

Degree: PhD, 2018, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:7d7d68df-3896-485f-af52-363c45fa5e07 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.770648

► Oligometastatic colorectal cancer represents an intermediate disease state potentially treatable with curative intent. Novel treatment strategies are expanding the opportunity to offer local treatment for… (more)

▼ Oligometastatic colorectal cancer represents an intermediate disease state potentially treatable with curative intent. Novel treatment strategies are expanding the opportunity to offer local treatment for limited metastatic disease. It is therefore increasingly important to define patients likely to benefit from these targeted treatments. Diagnostic imaging is central to patient management, to establish the burden and distribution of metastatic disease. This thesis explores the potential value of novel imaging biomarkers in patients with colorectal liver metastases (CRLM). In a prospective study, perfusion CT (pCT) and dynamic contrast-enhanced MRI (DCE-MRI) were performed prior to resection, and a retrospective series of patients with resected CRLM was collated. Resected metastases were analysed for relevant morphological features and IHC expression. Novel and conventional imaging variables were derived based on CT, MRI, pCT, DCE-MRI and ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG-PET), and their associations with histopathological features, immunohistochemical expression and patient outcomes analysed. A novel subregion analysis based on DCE-MRI data was developed to classify tumour subregions, using a histological reference standard. The results presented in this thesis confirm that the number and distribution of hepatic metastases are prognostic markers for patients with resected CRLM, and that higher SUVmean of liver metastases, and higher SUVmax of the background liver, are potential prognostic biomarkers. Histopathological assessment of resected CRLM highlighted that there is significant between and within patient variability of clinically relevant histopathological features and IHC expression, which would support the potential utility of imaging biomarkers to characterise multi- site disease. Analysis of functional imaging data demonstrated positive correlations between imaging variables and clinically relevant markers of tumour vascularity and metabolism, while subregion analysis of DCE-MRI data produced good spatial correlation with viable and non-viable tumour based on histopathology, with significant differences in derived phamacokinetic parameters between subregions.

Subjects/Keywords: Colorectal cancer; Imaging; Biomarkers

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APA (6^th Edition):

Franklin, J. M. (2018). Imaging biomarkers for oligometastatic colorectal cancer. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:7d7d68df-3896-485f-af52-363c45fa5e07 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.770648

Chicago Manual of Style (16^th Edition):

Franklin, James Michael. “Imaging biomarkers for oligometastatic colorectal cancer.” 2018. Doctoral Dissertation, University of Oxford. Accessed January 22, 2021. http://ora.ox.ac.uk/objects/uuid:7d7d68df-3896-485f-af52-363c45fa5e07 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.770648.

MLA Handbook (7^th Edition):

Franklin, James Michael. “Imaging biomarkers for oligometastatic colorectal cancer.” 2018. Web. 22 Jan 2021.

Vancouver:

Franklin JM. Imaging biomarkers for oligometastatic colorectal cancer. [Internet] [Doctoral dissertation]. University of Oxford; 2018. [cited 2021 Jan 22]. Available from: http://ora.ox.ac.uk/objects/uuid:7d7d68df-3896-485f-af52-363c45fa5e07 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.770648.

Council of Science Editors:

Franklin JM. Imaging biomarkers for oligometastatic colorectal cancer. [Doctoral Dissertation]. University of Oxford; 2018. Available from: http://ora.ox.ac.uk/objects/uuid:7d7d68df-3896-485f-af52-363c45fa5e07 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.770648

27. Abdelhady, Rasha. Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue.

Degree: PhD, 2018, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/characterizing-promutagenic-o6alkylguanine-adducts-in-human-colorectal-tissue(61792200-cb60-425c-b667-1ebe3b2b5192).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.771360

► Colorectal cancer is the third most commonly diagnosed cancer worldwide. The positive association between red and/or processed meat consumption and human colorectal cancer risk is… (more)

▼ Colorectal cancer is the third most commonly diagnosed cancer worldwide. The positive association between red and/or processed meat consumption and human colorectal cancer risk is well established potentially via heme-catalysed formation of carcinogenic N-nitrosocompounds (NNOC). These NNOC can form a range of O6- alkylguanine (O6-alkylG) adducts that may increase mutational and cancer risk. The overall aim of this study was to develop a novel approach to characterize the overall load of O6-alkylG adducts in human colorectal DNA using the known action of the DNA repair protein, O6-alkylguanine O6-alkyltransferase (MGMT) to irreversibly transfer the alkyl group from O6-alkylG to the MGMT active site peptide (MGMT-ASP). Incubation of chemically synthesised single (SS) and double stranded (DS) oligodeoxyribonucleotides (ODNs) containing O6-methylguanine (O6-MeG), O6- carboxyethylguanine (O6-CEG), but only DS O6-carboxymethylguanine (O6-CMG) -23 mer containing ODNs with MGMT resulted in MGMT inactivation. There was a preference for repair of DS ODNs. Recorded IC50 values were 0.17+0.02, 0.07+0.01, 15.7+2.1, 27.00+1.70 and 7.50+0.50 nanomolar (nM) for SS O6-MeG, DS O6-MeG, DS O6-CMG, SS O6-CEG, and DS O6-CEG, respectively. This repair was confirmed using a restriction endonuclease site deprotection assay as O6-MeG and O6-CEG inhibition of PstI digestion of ODNs, whilst, O6-CMG inhibited MboI. This inhibition was removed by pre-incubation with MGMT. Alkyl group transfer from these ODNs to a Maltose binding protein-MGMT (MBP-MGMT) fusion protein was demonstrated as alkylated active site peptides (ASPs) were detected using with Matrix assisted laser desorption/ionizationtime of flight (MALDI-TOF). S-methylcysteine (m/z 1329.7), and S-carboxyethylcysteine (m/z 1387.7) modified ASPs were detected following incubation of MBP-MGMT incubated with SS or DS O6-MeG, and O6-CEG ODNs, respectively. Scarboxymethylcysteine (m/z 1373.7) was detected with DS but not SS O6-CMG 23 mer ODN. Only the unmodified MGMT-ASP (m/z 1315.7) was found after incubating MGMT with unmodified ODN. Quantitative mass spectrometry (MS) findings highlighted that MGMT preferentially repaired specified adducts when presented in DS ODNs over SS ones. Temozolomide (TMZ) methylated calf thymus DNA (CT-DNA) and human colorectal cancer DNA samples were incubated with his tagged MGMT fusion protein (his-MGMT) and his-MGMT recovered using Ni-coated beads, digested in situ with trypsin and analysed by MALDI-TOF. MS analysis of tryptic digests of MGMT incubated with methylated CT-DNA revealed methylated MGMT-ASP, detecting as low as 50 fmole of O6-MeG/mg CT-DNA. This approach was applied to 13 human colorectal DNA samples, 12 of them showed evidence of O6 alkylation damage. Of 13 samples, 12 contained O6-MeG, 8 contained O6-CMG and 1 contained O6-HOEtG. A further 7 peaks were detected with a signal/noise (S/N) ratio of >10, potentially, correspond to alkylated MGMT-ASP ions but identities of the alkyl groups are as yet unknown. These results demonstrate proof of…

Subjects/Keywords: O6-alkylguanine adducts; Colorectal cancer

10 more images…

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APA (6^th Edition):

Abdelhady, R. (2018). Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/characterizing-promutagenic-o6alkylguanine-adducts-in-human-colorectal-tissue(61792200-cb60-425c-b667-1ebe3b2b5192).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.771360

Chicago Manual of Style (16^th Edition):

Abdelhady, Rasha. “Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue.” 2018. Doctoral Dissertation, University of Manchester. Accessed January 22, 2021. https://www.research.manchester.ac.uk/portal/en/theses/characterizing-promutagenic-o6alkylguanine-adducts-in-human-colorectal-tissue(61792200-cb60-425c-b667-1ebe3b2b5192).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.771360.

MLA Handbook (7^th Edition):

Abdelhady, Rasha. “Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue.” 2018. Web. 22 Jan 2021.

Vancouver:

Abdelhady R. Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue. [Internet] [Doctoral dissertation]. University of Manchester; 2018. [cited 2021 Jan 22]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/characterizing-promutagenic-o6alkylguanine-adducts-in-human-colorectal-tissue(61792200-cb60-425c-b667-1ebe3b2b5192).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.771360.

Council of Science Editors:

Abdelhady R. Characterizing pro-mutagenic O6-alkylguanine adducts in human colorectal tissue. [Doctoral Dissertation]. University of Manchester; 2018. Available from: https://www.research.manchester.ac.uk/portal/en/theses/characterizing-promutagenic-o6alkylguanine-adducts-in-human-colorectal-tissue(61792200-cb60-425c-b667-1ebe3b2b5192).html ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.771360

University of Edinburgh

28. Briffa, Romina. Towards functional multiscale analysis of colorectal cancer.

Degree: PhD, 2014, University of Edinburgh

URL: http://hdl.handle.net/1842/16230

► Background: The five year overall survival rate for colorectal cancer (CRC) patients varies between 38.8% and 59.9%. Selecting patients who are likely to respond to… (more)

▼ Background: The five year overall survival rate for colorectal cancer (CRC) patients varies between 38.8% and 59.9%. Selecting patients who are likely to respond to therapy remains a clinical and pathological challenge, hence the need for predictive and prognostic biomarkers. The objectives of this study were: 1) to establish which genes were differentially expressed with respect to sensitivity to treatment, 2) to integrate the list of differentially expressed genes with copy number to systematically identify predictive biomarkers, and 3) to establish which genes are commonly gained in the panel of CRC cell lines. As proof of concept of the approach the copy number variations of the identified genes were assessed in a cohort of Dukes’ A and B cancers, in order to analyse the likelihood of these genes acting as useful biomarkers. Methods: Cell viability assays were carried out on a panel 15 CRC cell lines. IC50s were measured for 5-fluoruracil (5-FU), oxaliplatin (L-OHP), and BEZ-235, a PI3K/mTOR inhibitor. We carried out a systematic array-based survey of gene expression and copy number variation in CRC cell lines, and compared these to responses to different treatments. Cell lines were profiled using array comparative genomic hybridisation (aCGH; NimbleGen 135k), Illumina gene expression analysis, reverse phase protein arrays (RPPA), and targeted sequencing of KRAS hotspot mutations. The associations between the biological variables and drug sensitivity were assessed using correlation coefficients, chi-square analysis, and the Mann Whitney-U test. Tissue microarrays (TMA) were constructed for a cohort of CRC patients (n=118) and TRIB1 and MYC amplifications were measured using fluorescence in situ hybridisation (FISH). The protein expression for trib1 and 14 associated biomarkers were investigated using Automated Quantitative Analysis (AQUA) and analysed using the Pearson’s correlation coefficient. Results: Twenty-three regions were frequently gained, and fourteen regions were lost across the cell line panel. Gains were observed at 2p, 3q, 5p, 7p, 7q, 8q, 12p, 13q, 14q, and 17q, and losses at 2q, 3p, 5q, 8p, 9p, 9q, 14q, 18q, and 20p. Frequently gained regions contained EGFR, PIK3CA, MYC, SMO, TRIB1, FZD1, and BRCA2, while frequently lost regions contained FHIT and MACROD2. Gene enrichment analysis showed that differentially expressed genes with respect to treatment response were involved in Wnt signalling, EGF receptor signalling, apoptosis, cell cycle, and angiogenesis. Stepwise integration of copy number and gene expression data yielded 47 candidate genes that were significantly correlated (corrected p-value ≤0.05). Differentially expressed genes common to all three treatment responses included AEBP2, DDX56, MRPL32, MRPS17, MYC, NSMCE2, and TBRG4. TRIB1 (n=76) and MYC (n=81) were amplified (FISH score ≥1.8) in 14.5% and 7.4% of the CRC cohort, respectively. TRIB1 and MYC amplifications were significantly correlated (corrected p-value ≤ 0.0001). Trib1 protein expression in the patient cohort was significantly…

Subjects/Keywords: 616.99; molecular pathology; colorectal cancer

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APA (6^th Edition):

Briffa, R. (2014). Towards functional multiscale analysis of colorectal cancer. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/16230

Chicago Manual of Style (16^th Edition):

Briffa, Romina. “Towards functional multiscale analysis of colorectal cancer.” 2014. Doctoral Dissertation, University of Edinburgh. Accessed January 22, 2021. http://hdl.handle.net/1842/16230.

MLA Handbook (7^th Edition):

Briffa, Romina. “Towards functional multiscale analysis of colorectal cancer.” 2014. Web. 22 Jan 2021.

Vancouver:

Briffa R. Towards functional multiscale analysis of colorectal cancer. [Internet] [Doctoral dissertation]. University of Edinburgh; 2014. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1842/16230.

Council of Science Editors:

Briffa R. Towards functional multiscale analysis of colorectal cancer. [Doctoral Dissertation]. University of Edinburgh; 2014. Available from: http://hdl.handle.net/1842/16230

University of Gothenburg / Göteborgs Universitet

29. Zou, Zhiyuan. Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer.

Degree: 2018, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/54952

► Colorectal cancer (CRC) is a cancer that occurs in the colon or rectum and is one of the most common cancer forms and a leading… (more)

▼ Colorectal cancer (CRC) is a cancer that occurs in the colon or rectum and is one of the most common cancer forms and a leading cause of cancer death in the Western world. The majority of CRCs are caused by inherited or somatic mutations in the APC gene. The ApcMin model is driven by a truncating mutation in the Apc gene and is considered to be one of the best mouse models of CRC. The aim of this thesis is to uncover novel mechanisms behind the initiation and progression of intestinal adenomas in ApcMin/+ mice. Clinical studies suggest that the transcription factor Zfp148 may play a role in CRC but the importance of Zfp148 for tumor development has not been properly investigated. We have previously shown that Zfp148 is a potent inhibitor of p53 and hypothesized that Zfp148 deficiency may protect against CRC by increasing p53-activity. In paper I, we show that deletion of one or both copies of Zfp148 markedly reduces tumor formation in ApcMin/+ mice. The result shows that Zfp148 controls the fate of newly transformed tumor cells by repressing p53, and suggests that targeting Zfp148 might be useful in the treatment of colorectal cancer. Previous studies show that Zfp148 inhibits activation of p53; however, the underlying mechanism is not understood. We have previously shown that transcription of Cdkn2a was increased in Zfp148 deficient MEFs. ARF is one of two products of Cdkn2a and is a major activator of the p53-pathway. Therefore, we hypothesized that Zfp148 inhibits p53 by repressing ARF. In paper II, we tested this hypothesis in mouse embryoblasts (MEFs) and found that Zfp148 regulates cell proliferation and p53 activity by repressing the transcription of ARF. Finally, we addressed the role of antioxidants. Clinical studies on the ability of dietary antioxidants to prevent CRC show inconsistent results. To understand the effect of antioxidants, we gave two types of dietary antioxidants to ApcMIn/+ mice and investigated tumor development. Our results indicate that dietary antioxidants have no effect on tumor initiation but accelerate progression of existing tumors. The result raises concerns about the widespread use of dietary antioxidants, especially among high risk populations.

Subjects/Keywords: colorectal cancer; ApcMin mouse

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APA (6^th Edition):

Zou, Z. (2018). Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/54952

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zou, Zhiyuan. “Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer.” 2018. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 22, 2021. http://hdl.handle.net/2077/54952.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zou, Zhiyuan. “Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer.” 2018. Web. 22 Jan 2021.

Vancouver:

Zou Z. Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2018. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/2077/54952.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zou Z. Mechanisms of intestinal tumor initiation and progression in ApcMin mouse model of colorectal cancer. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2018. Available from: http://hdl.handle.net/2077/54952

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New Mexico

30. Woersching, Alex L. An Assessment of Health Insurance Features as Predictors of Colorectal Cancer Screening.

Degree: College of Pharmacy, 2015, University of New Mexico

URL: http://hdl.handle.net/1928/25764

► Health insurance design influences whether a person will receive health services, including colorectal cancer (CRC) screening, although how insurance design influences utilization is not fully… (more)

▼ Health insurance design influences whether a person will receive health services, including colorectal cancer (CRC) screening, although how insurance design influences utilization is not fully explained. By disaggregating types of insurance into discrete organizational and financial features, specific influential factors may be identifiable. This study evaluated insurance features as predictors of CRC screening using data from the 2009, 2010, and 2011 Medical Expenditure Panel Survey. Studied insurance features included three organizational features: whether a persons insurance defined a provider network (DPN), used gatekeeping, and restricted coverage to a DPN; and two financial features: whether a person had a Flexible Spending Account (FSA) and categories of cost-sharing experience during the survey year. The primary outcome studied was whether a person was up-to-date with United States (US) Preventive Services Task Force (USPSTF)-recommended CRC screening. In sensitivity analyses, any previous-year CRC screening was evaluated as an alternative outcome to assess if insurance features more strongly affected short-term screening than longer-term USPSTF screening. Multivariate logistic regression models were devised to separately evaluate each insurance feature. In smaller samples of the Western US, secondary analyses evaluated if insurance features differentially affected CRC screening among Hispanic versus non-Hispanic whites. In the logistic models of the full US samples, organizational insurance features did not significantly predict the USPSTF outcome. A significant, >3% point, increase in any previous-year CRC screening was predicted by having two features, gatekeeping and coverage restricted to a DPN. The third organizational feature, having coverage restricted to a DPN, had a non-significant positive effect. In the Western US analyses, each organizational feature predicted a more favorable change in screening likelihood for Western Hispanic whites than non-Hispanic whites suggesting a possible effect of reducing disparate CRC screening among Hispanics. For the financial features in the full and Western US analyses, having a FSA had a large positive effect in unadjusted models, although the effect did not remain significant in fully-adjusted models. Cost-sharing categories predicted substantial variation in screening likelihood, which was largely mitigated in fully-adjusted models. Further research is needed using causal study designs and datasets with richer detail about insurance design. Advisors/Committee Members: Borrego, Matthew, Borrego, Matthew, Gonzales, Melissa, van der Goes, David.

Subjects/Keywords: health insurance; colorectal cancer; screening

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APA (6^th Edition):

Woersching, A. L. (2015). An Assessment of Health Insurance Features as Predictors of Colorectal Cancer Screening. (Masters Thesis). University of New Mexico. Retrieved from http://hdl.handle.net/1928/25764

Chicago Manual of Style (16^th Edition):

Woersching, Alex L. “An Assessment of Health Insurance Features as Predictors of Colorectal Cancer Screening.” 2015. Masters Thesis, University of New Mexico. Accessed January 22, 2021. http://hdl.handle.net/1928/25764.

MLA Handbook (7^th Edition):

Woersching, Alex L. “An Assessment of Health Insurance Features as Predictors of Colorectal Cancer Screening.” 2015. Web. 22 Jan 2021.

Vancouver:

Woersching AL. An Assessment of Health Insurance Features as Predictors of Colorectal Cancer Screening. [Internet] [Masters thesis]. University of New Mexico; 2015. [cited 2021 Jan 22]. Available from: http://hdl.handle.net/1928/25764.

Council of Science Editors:

Woersching AL. An Assessment of Health Insurance Features as Predictors of Colorectal Cancer Screening. [Masters Thesis]. University of New Mexico; 2015. Available from: http://hdl.handle.net/1928/25764

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