subject:(Cancer Treatment)

Rutgers University

1. Panda, Anshuman, 1990-. Biomarkers of response to immune checkpoint therapy.

Degree: PhD, Physics and Astronomy, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/56075/

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Immune checkpoint therapy leads to durable objective response in a subset of patients with metastatic cancer in many different cancer types, but the mechanisms and… (more)

Subjects/Keywords: Cancer – Treatment

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APA (6^th Edition):

Panda, Anshuman, 1. (2018). Biomarkers of response to immune checkpoint therapy. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/56075/

Chicago Manual of Style (16^th Edition):

Panda, Anshuman, 1990-. “Biomarkers of response to immune checkpoint therapy.” 2018. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/56075/.

MLA Handbook (7^th Edition):

Panda, Anshuman, 1990-. “Biomarkers of response to immune checkpoint therapy.” 2018. Web. 16 Jan 2021.

Vancouver:

Panda, Anshuman 1. Biomarkers of response to immune checkpoint therapy. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/56075/.

Council of Science Editors:

Panda, Anshuman 1. Biomarkers of response to immune checkpoint therapy. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/56075/

Nelson Mandela Metropolitan University

2. Knoetze, Steyn. The development of novel cancer targeting agents.

Degree: Faculty of Science, 2011, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/d1010636

► The search for the cure for cancer is currently a multi-billion dollar industry and the search for the elusive “magic bullet”, i.e. the perfect cancer… (more)

▼ The search for the cure for cancer is currently a multi-billion dollar industry and the search for the elusive “magic bullet”, i.e. the perfect cancer drug that would interact therapeutically with cancerous tissues while having a minimal effect on healthy cells, is the topic of many research studies in the world today. A large number of novel drugs or drug complexes and conjugates are being synthesized and subjected to rigorous evaluation in the race to find the perfect cure. ECDG (Ethylene diCysteine DeoxyGlucose) seems to have promising cancer targeting ability. Even though this compound has been described in a few publications, we could not find any reference to the current use of ECDG in oncology clinics, either as a therapeutic agent, or as a diagnostic tool for imaging purposes. It was also not possible to purchase pure ECDG anywhere in the world. This prompted us to further investigate ECDG as a possible candidate for cancer targeting research, either as an imaging agent for cancer diagnosis or complexed with an anti-cancer agent for therapeutic purposes. Detailed investigations done in our laboratory can be divided into the following categories: - Development of a synthetic method for ECDG on a multigram scale ; - Purification of prepared ECDG not using the described dialysis method that only allows the purification of small quantities of ECDG (mg scale) ; Detailed investigation of the chemistry involved in the preparation of pure ECDG and its metal complexes ; - Investigation of the stability of ECDG and its metal complexes that is essential data required for any pharmaceutical agent ; - Preparation of ECDG complexes for use as a diagnostic tool, i.e. complexation with 99mTc ; Investigation of the bio distribution of ECDG-ReO complexes ; - Preparation of an ECDG kit as a diagnostic tool for use in oncology clinics. The development of novel aromatic ligands having similar characteristics compared to ECDG, containing an N2S2 chromophore as donor atoms, to further investigate their targeting capabilities, have also been investigated. All intermediates and final compounds were characterized mainly by ESI MS, in some cases IR and NMR whenever available. Successful preparation and purification of ECDG ands its metal complexes was achieved and extensively characterized and evaluated. Efforts directed towards the development of ECDG at NECSA, South Africa, were also rewarded with significant success. Furthermore, significant development regarding the synthesis of two novel compounds with ECDG-like characteristics was also completed.

Subjects/Keywords: Cancer – Research; Cancer – Treatment

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APA (6^th Edition):

Knoetze, S. (2011). The development of novel cancer targeting agents. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/d1010636

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Knoetze, Steyn. “The development of novel cancer targeting agents.” 2011. Thesis, Nelson Mandela Metropolitan University. Accessed January 16, 2021. http://hdl.handle.net/10948/d1010636.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Knoetze, Steyn. “The development of novel cancer targeting agents.” 2011. Web. 16 Jan 2021.

Vancouver:

Knoetze S. The development of novel cancer targeting agents. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2011. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10948/d1010636.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Knoetze S. The development of novel cancer targeting agents. [Thesis]. Nelson Mandela Metropolitan University; 2011. Available from: http://hdl.handle.net/10948/d1010636

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

3. Atsednesh, Getachew. Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital .

Degree: 2014, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/5483

► Cancer, one of the non-communicable diseases is gaining momentum in Ethiopia. As the country has only one cancer treatment center for both adults and children,… (more)

Subjects/Keywords: Childhood Cancer; Cancer Treatment

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APA (6^th Edition):

Atsednesh, G. (2014). Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Atsednesh, Getachew. “Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital .” 2014. Thesis, Addis Ababa University. Accessed January 16, 2021. http://etd.aau.edu.et/dspace/handle/123456789/5483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Atsednesh, Getachew. “Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital .” 2014. Web. 16 Jan 2021.

Vancouver:

Atsednesh G. Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital . [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Jan 16]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5483.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Atsednesh G. Psychosocial Impact of Childhood Cancer on Parents with Children Diagnosed with Cancer: The Case of Parents Receiving Service at Tikur Anbessa Specialized Hospital . [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5483

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Deakin University

4. Binder, Marley. Characterization of ADAMTS-15: a potential tumor suppressor gene in prostate cancer.

Degree: School of Medicine, 2016, Deakin University

URL: http://hdl.handle.net/10536/DRO/DU:30102696

In prostate cancer versican is up-regulated and ADAMTS-15 down-regulated. In this PhD ADAMTS-15 decreased migration, proliferation and apoptosis in vitro, and prolonged survival in castrated NOD/SCID mice injected with tumor cells, and was shown to be co-localized with versican and its cleaved form versikine in human patient biopsies.

Subjects/Keywords: prostate cancer; cancer treatment

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APA (6^th Edition):

Binder, M. (2016). Characterization of ADAMTS-15: a potential tumor suppressor gene in prostate cancer. (Thesis). Deakin University. Retrieved from http://hdl.handle.net/10536/DRO/DU:30102696

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Binder, Marley. “Characterization of ADAMTS-15: a potential tumor suppressor gene in prostate cancer.” 2016. Thesis, Deakin University. Accessed January 16, 2021. http://hdl.handle.net/10536/DRO/DU:30102696.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Binder, Marley. “Characterization of ADAMTS-15: a potential tumor suppressor gene in prostate cancer.” 2016. Web. 16 Jan 2021.

Vancouver:

Binder M. Characterization of ADAMTS-15: a potential tumor suppressor gene in prostate cancer. [Internet] [Thesis]. Deakin University; 2016. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10536/DRO/DU:30102696.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Binder M. Characterization of ADAMTS-15: a potential tumor suppressor gene in prostate cancer. [Thesis]. Deakin University; 2016. Available from: http://hdl.handle.net/10536/DRO/DU:30102696

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Missouri – Columbia

5. Suresh, Dhananjay. Cubic and spherical nanoparticles for detection and therapy of cancer.

Degree: 2016, University of Missouri – Columbia

URL: http://hdl.handle.net/10355/62484

► Cancer is the leading cause of high mortality rates. Cancer patients require advanced treatment due to lack of early prevention and diagnosis. Moreover, progression of… (more)

▼ Cancer is the leading cause of high mortality rates. Cancer patients require advanced treatment due to lack of early prevention and diagnosis. Moreover, progression of the disease is unpredictable and personalized therapy options are being explored. Existing cancer therapy leads to drug resistance that worsens patient survival rates, and thus disease management is challenging. This necessitates the need to understand the underlying cause, early detection of possible biomarkers, monitor the disease state and develop effective therapeutics. Current innovations in cancer detection and therapy includes use of newer class of smart nanomaterials. These advances in nanoscale materials, due to their unique size, chemical and physical properties, make them ideal for nanomedicinal and nanoelectronic applications. The work performed in this thesis describes the design and the synthesis of cubic and spherical nanoparticles, and their subsequent applications toward energy interactions, biochemical interactions and cellular targeting. Details of receptor mediated endocytic mechanism, targeted capture of circulating tumor cells (CTC), athermal mechanism of controlled release of biomolecules from nanoparticles using femtosecond pulses, and targeted siRNA delivery using nanoparticles have been explained. Mechanistic studies showed that receptor targeting follows a clathrin mediated endocytic pathway. Receptor-targeted nanoparticles showed effective capture of EpCAM-negative CTCs. The cubic shaped nanoparticles were found to enhance the plasmon-photon coupling to efficiently release biomolecules. Spherical nanoparticle mediated siRNA delivery resensitized drug resistant NSCLC by downregulating two important oncogenes, AXL and FN14 as observed by both in vitro and in vivo studies. Additionally, the study highlights drug resensitization following the effective knockdown of AXL using CRISPR based gene editing. Overall, the results demonstrate the application of nanoparticles for advanced diagnostics and therapeutics. Advisors/Committee Members: Kannan, Raghuraman (advisor).

Subjects/Keywords: Cancer – Treatment; Cancer – Diagnosis; Nanoparticles

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APA (6^th Edition):

Suresh, D. (2016). Cubic and spherical nanoparticles for detection and therapy of cancer. (Thesis). University of Missouri – Columbia. Retrieved from http://hdl.handle.net/10355/62484

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Suresh, Dhananjay. “Cubic and spherical nanoparticles for detection and therapy of cancer.” 2016. Thesis, University of Missouri – Columbia. Accessed January 16, 2021. http://hdl.handle.net/10355/62484.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Suresh, Dhananjay. “Cubic and spherical nanoparticles for detection and therapy of cancer.” 2016. Web. 16 Jan 2021.

Vancouver:

Suresh D. Cubic and spherical nanoparticles for detection and therapy of cancer. [Internet] [Thesis]. University of Missouri – Columbia; 2016. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10355/62484.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Suresh D. Cubic and spherical nanoparticles for detection and therapy of cancer. [Thesis]. University of Missouri – Columbia; 2016. Available from: http://hdl.handle.net/10355/62484

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

6. Luo, Fang, 1967-. Predictive modeling for in-hospital mortality in pancreatic cancer patients.

Degree: PhD, Biomedical Informatics, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48235/

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Background: Pancreatic cancer is very aggressive with few symptoms before the cancer can diagnosed and usually the cancer is advanced when it was found. It… (more)

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Background: Pancreatic cancer is very aggressive with few symptoms before the cancer can diagnosed and usually the cancer is advanced when it was found. It is the most deadly type of cancer, and it is listed as the fourth leading cause of cancer-related death with a poor prognosis because of the late finding of the disease. To patients, the pancreatic cancer diagnosis is a life-changing disaster; however, to maximally extend the pancreatic cancer patients’ life is most important task after diagnosis. In this research study, we found certain statistical significant relationships between the death of pancreatic cancer patients and the comorbidities & demographics. Furthermore, patients with some comorbidities or demographics can make their life longer or shorter. Objectives: To develop a mathematic model to predict the death of pancreatic cancer patients using certain patients’ comorbidities and demographics. Also, pancreatic cancer patients with certain comorbidities or demographics can predict their rest of life will be longer or shorter. Methods: The study uses HCUP NIS year 2005-2009 data files as research source database. With retrieving pancreatic cancer patient from NIS data files, the database used in this study includes pancreatic cancer patients’ information with their comorbidities and some demographics. The algorithm used in this research study in 1) Logistic regression ROC curve calculation 2) Logistic regression Odds Ratio calculation. Results: 1) In output ROC curve, the area under the ROC curve (AUC) is 0.725 which is >0.5. It means when randomly pick one patient from the disease group (diagnosed as pancreatic cancer) and one from the no-disease group (not diagnosed as pancreatic cancer) and do the test on both. The patient with the more abnormal test result (Died) should be the one from the disease group (diagnosed as pancreatic cancer). 2) 11 comorbidities can significantly influence on life of pancreatic cancer patients, both LCL and UCL of odds ratio are either <1 or >1 in all 11 comorbidities, which means if patients were diagnosed as one of 11 comorbidities, they might either live longer or live shorter. Conclusions: The study results were cross verified by 3 types of cancer patients, which is pancreatic cancer, breast cancer and stomach cancer. Those 11 comorbidities have the same statistical significance effect on influencing patients’ life. So far no literatures can be found on such kind of study, this study can be considered as a new research field in the future.

Advisors/Committee Members: MITAL, DINESH P (chair), Srinivasan, Shankar (internal member), Coffman, Frederick (internal member), School of Health Professions.

Subjects/Keywords: Pancreas – Cancer – Treatment; Cancer – Patients

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APA (6^th Edition):

Luo, Fang, 1. (2015). Predictive modeling for in-hospital mortality in pancreatic cancer patients. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48235/

Chicago Manual of Style (16^th Edition):

Luo, Fang, 1967-. “Predictive modeling for in-hospital mortality in pancreatic cancer patients.” 2015. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/48235/.

MLA Handbook (7^th Edition):

Luo, Fang, 1967-. “Predictive modeling for in-hospital mortality in pancreatic cancer patients.” 2015. Web. 16 Jan 2021.

Vancouver:

Luo, Fang 1. Predictive modeling for in-hospital mortality in pancreatic cancer patients. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48235/.

Council of Science Editors:

Luo, Fang 1. Predictive modeling for in-hospital mortality in pancreatic cancer patients. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48235/

Rhodes University

7. Chiwakata, Maynard Tendai. The synthesis and breast cancer inhibitory activity of cinnamic acid analogues based on the halogenated monoterpene pharmacophore.

Degree: MS, Faculty of Pharmacy, Pharmacy, 2012, Rhodes University

URL: http://hdl.handle.net/10962/d1016129

► Breast cancer is one of the leading causes of death, with mortality rate estimates of 465 000 deaths per annum. It is estimated that 1.3… (more)

▼ Breast cancer is one of the leading causes of death, with mortality rate estimates of 465 000 deaths per annum. It is estimated that 1.3 million women are diagnosed with the disease each year especially in the developing countries. Current chemotherapy relies on the use of high doses of non-specific toxic agents that possess adverse side effects and compromise patient’s compliance and adherence to treatment. Paclitaxel, one of the common drugs used in breast cancer chemotherapy results in sensory and motor neuropathy, whilst hormonal therapy e.g. Herceptin causes severe cardiovascular, gastrointestinal and cutaneous side effects. There has been a demand in developing newer cancer agents that demonstrate selective cytoxicity with minimal effect on normal body tissue. Numerous studies have shown that marine organisms produce a wide range of halogenated compounds that possess cytotoxic properties, and hence can be a source of new drug hits or leads for cancer therapy. Halomon, a polyhalogenated monoterpene from Portieria hornemannii, displayed interesting activity against brain, renal and lung cancer tumours with selective/differential cytotoxicity. This inspired us to focus our project on halogenated monoterpenes isolated from the same Rhodophyta class as P. hornemannii but with particular attention to Plocamium species. Several metabolites have been isolated from P. cornutum, P. corallorhiza and P. suhrii that possess interesting cytotoxicities against a breast cancer cell line (MCF7) and an oesophageal cancer line (WHCO1). The aim of the project was therefore centred at isolating target compounds for preliminary structure-activity studies against a breast cancer cell line, and use this information to synthesize a series of analogues that are more stable than the natural products and yet as active using a fragment-based type approach to map out pharmacophoric elements. Five metabolites were isolated from P. cornutum and five from P. corallorhiza. Cell-based assays were conducted using an MTT assay kit against MCF7 and MDA-MB-231 breast cancer cell lines and (1E,3E,5S,6R)-1,5,6-trichloro-2-(dichloromethyl)-6-methylocta-1,3,7-triene, isolated from P. cornutum was the most active with IC50 values of 3.0 μM and 6.15 μM respectively. Introduction of a terminal aromatic ring to enhance stability, together with varying substituents (H, CH3, CF3, Br, CN, CHO, CHCl2) on position 7 of the molecule, gave rise to a series of cinnamate ester derivatives inspired by (1E,3E,5S,6R)-1,5,6-trichloro-2-(dichloromethyl)-6-methylocta-1,3,7-triene. The analogues were synthesized from their benzaldehyde precursors via Aldol condensation, esterification and Wittig reactions. Their carboxylic acid counterparts were synthesized by hydrolysis of the parent esters in an attempt to promote water solubilities of the analogues. Biological activity assays were then conducted with the cinnamate analogues against the MDA-MB-231 breast cancer cell line using an MTT assay kit. Ester derivatives with -CHO and -CHCl2 functionalities had IC50 values of…

Subjects/Keywords: Halocarbons; Cancer – Treatment; Breast – Cancer – Treatment

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APA (6^th Edition):

Chiwakata, M. T. (2012). The synthesis and breast cancer inhibitory activity of cinnamic acid analogues based on the halogenated monoterpene pharmacophore. (Masters Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1016129

Chicago Manual of Style (16^th Edition):

Chiwakata, Maynard Tendai. “The synthesis and breast cancer inhibitory activity of cinnamic acid analogues based on the halogenated monoterpene pharmacophore.” 2012. Masters Thesis, Rhodes University. Accessed January 16, 2021. http://hdl.handle.net/10962/d1016129.

MLA Handbook (7^th Edition):

Chiwakata, Maynard Tendai. “The synthesis and breast cancer inhibitory activity of cinnamic acid analogues based on the halogenated monoterpene pharmacophore.” 2012. Web. 16 Jan 2021.

Vancouver:

Chiwakata MT. The synthesis and breast cancer inhibitory activity of cinnamic acid analogues based on the halogenated monoterpene pharmacophore. [Internet] [Masters thesis]. Rhodes University; 2012. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10962/d1016129.

Council of Science Editors:

Chiwakata MT. The synthesis and breast cancer inhibitory activity of cinnamic acid analogues based on the halogenated monoterpene pharmacophore. [Masters Thesis]. Rhodes University; 2012. Available from: http://hdl.handle.net/10962/d1016129

Rutgers University

8. Joseph, Susan Kalapura, 1980-. Understanding barriers in early stage breast cancer treatment.

Degree: PhD, Public Health, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/59126/

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Introduction: A deeper understanding of barriers in early stage breast cancer treatment and the ways patients respond to these barriers can be used to develop,… (more)

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Introduction: A deeper understanding of barriers in early stage breast cancer treatment and the ways patients respond to these barriers can be used to develop, assess, and identify patient behaviors that may negatively impact treatment decision-making. Objectives: With regard to delays in time to diagnosis and treatment, refusal of treatment, and surgical choice issues in early stage breast cancer: 1) examine barriers faced by patients at the patient, care process, and health system–levels and examine responses to these barriers; 2) identify the patient behavior types that lead to poor treatment decision-making; and 3) discuss observations by patient race, age, and socioeconomic status and suggest interventions that can help address barriers. Methods: African American and European American patients diagnosed with early stage breast cancer between 2005 and 2011 were identified in northern and central New Jersey. Patients were between age 20 and 85 years at diagnosis and were identified through rapid case ascertainment methodology by the New Jersey State Cancer Registry Staff. Three data collection methods were used: 1) face-to-face in-depth interviews; 2) semi-structured telephone interviews; and 3) medical chart abstraction. Analyses of patient transcripts were conducted using Atlas.ti qualitative data analysis software. Results: In objective 1, delays in time to diagnosis and treatment resulted from behaviors described as ‘seriousness-unaware,’ refusal of treatment resulted from behaviors described as ‘treatment avoidance,’ and surgical choice issues resulted from behaviors described as ‘low involvement’ and ‘body image priority.’ Per objective 2, poor treatment decision-making largely resulted from the experience of a higher proportion of barriers at the patient-level for all three treatment decisions as compared to barriers at the care process-level and health system-level, suggesting the need for interventions that directly impact patients. Per objective 3, responses to barriers varied by patient race, age, and socioeconomic status and targeted interventions and assistance can be used to address these patient experiences. Interventions such as developing an assessment tool to identify patient behaviors that may negatively impact treatment decision-making can be incorporated as alerts in data collection systems. An independent entity can also be utilized to survey early stage breast cancer patients on a monthly basis to ensure objective feedback about the treatment process is obtained and that appropriate actions are taken. Conclusion: Patient behaviors which led to poor treatment decision-making in early stage breast cancer were observed. Additional assistance provided to patients when they are experiencing challenges during the treatment process can improve survival, adherence, and satisfaction with treatment. Findings in this study suggest that interventions are needed to eliminate barriers that can reduce disparities in early stage breast cancer treatment.

Advisors/Committee Members: Joseph, Susan Kalapura, 1980- (author), Monheit, Alan (chair), West, Bernadette (co-chair), DEMISSIE, KITAW (internal member), Balasubramanian, Bijal (outside member), School of Graduate Studies.

Subjects/Keywords: Breast – Cancer – Treatment

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APA (6^th Edition):

Joseph, Susan Kalapura, 1. (2018). Understanding barriers in early stage breast cancer treatment. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/59126/

Chicago Manual of Style (16^th Edition):

Joseph, Susan Kalapura, 1980-. “Understanding barriers in early stage breast cancer treatment.” 2018. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/59126/.

MLA Handbook (7^th Edition):

Joseph, Susan Kalapura, 1980-. “Understanding barriers in early stage breast cancer treatment.” 2018. Web. 16 Jan 2021.

Vancouver:

Joseph, Susan Kalapura 1. Understanding barriers in early stage breast cancer treatment. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59126/.

Council of Science Editors:

Joseph, Susan Kalapura 1. Understanding barriers in early stage breast cancer treatment. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/59126/

Rutgers University

9. Yin, Perry, 1988-. Multifunctional nanoparticle-based approaches to enhance the treatment of cancer.

Degree: PhD, Biomedical Engineering, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/49349/

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Magnetic nanoparticles (MNPs) hold tremendous potential for various biomedical applications, including cancer diagnosis and treatment, owing to their unique ability to be manipulated by magnetic… (more)

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Magnetic nanoparticles (MNPs) hold tremendous potential for various biomedical applications, including cancer diagnosis and treatment, owing to their unique ability to be manipulated by magnetic fields. In particular, cancer applications of MNPs have primarily utilized MNPs as MRI contrast agents, drug delivery vehicles, and as agents for magnetic hyperthermia. Significant progress has already been made in the advancement of MNP-based therapies to the clinic; however, tumor targeting and chemoresistance remain significant challenges. Addressing these challenges, this thesis focuses on the development of novel multifunctional MNP-based combination therapies. In the first half of this thesis, novel MNP and magnetic core-shell nanoparticle (MCNP)-based combination therapies are developed to enhance the treatment of cancer by sensitizing cancer cells to subsequent therapies. To this end, MNPs are first developed for the dual purpose of delivering microRNA and inducing magnetic hyperthermia for the treatment of brain cancer. We demonstrate that the combination of lethal-7a microRNA (let-7a), which targets a number of survival pathways, can sensitize cancer cells to subsequent magnetic hyperthermia. Moreover, we demonstrate the use of MCNPs that are composed of a magnetic core and a mesoporous silica shell for the simultaneous delivery of let-7a and doxorubicin, wherein let-7a was found to sensitize breast cancer cells to subsequent doxorubicin chemotherapy. In the second half of this thesis, to overcome poor tumor targeting, a stem cell-based gene therapy is developed. Specifically, MCNPs are reported for the dual purpose of delivering and activating a heat-inducible gene vector that encodes TNF-related apoptosis-inducing ligand (TRAIL) in adipose-derived mesenchymal stem cells (AD-MSCs) for the treatment of ovarian cancer. These engineered AD-MSCs retained their innate ability to home to tumors, making them ideal cellular carriers for cancer therapy. Moreover, mild magnetic hyperthermia resulted in the selective expression of TRAIL in the engineered AD-MSCs thereby inducing significant cancer cell death. Overall, this thesis has demonstrated two multifunctional MNP-based approaches for cancer therapy: 1) combined MNP-based delivery of microRNA and magnetic hyperthermia to sensitize cancers to subsequent chemotherapy and 2) MCNP-based activation of heat-inducible genes in stem cells for targeted cancer treatment.

Advisors/Committee Members: Lee, Ki-Bum (chair), Cai, Li (internal member), Roth, Charles (internal member), Suh, Nanjoo (outside member).

Subjects/Keywords: Cancer – Treatment; Nanostructures

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APA (6^th Edition):

Yin, Perry, 1. (2016). Multifunctional nanoparticle-based approaches to enhance the treatment of cancer. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/49349/

Chicago Manual of Style (16^th Edition):

Yin, Perry, 1988-. “Multifunctional nanoparticle-based approaches to enhance the treatment of cancer.” 2016. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/49349/.

MLA Handbook (7^th Edition):

Yin, Perry, 1988-. “Multifunctional nanoparticle-based approaches to enhance the treatment of cancer.” 2016. Web. 16 Jan 2021.

Vancouver:

Yin, Perry 1. Multifunctional nanoparticle-based approaches to enhance the treatment of cancer. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49349/.

Council of Science Editors:

Yin, Perry 1. Multifunctional nanoparticle-based approaches to enhance the treatment of cancer. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49349/

Rutgers University

10. Zhu, Xunan, 1991-. Design of self-assembled zein-based nanoparticles as an effective drug carrier and transporter.

Degree: PhD, Food Science, 2019, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/60120/

► Cancer is the second leading cause of death in the world. General characteristics of tumors include abnormal blood vessels and lack of lymphatic system. Due… (more)

▼ Cancer is the second leading cause of death in the world. General characteristics of tumors include abnormal blood vessels and lack of lymphatic system. Due to large sizes, drug-loaded delivery systems cannot diffuse out the tumor blood vessels, as a result of progressive accumulation: the EPR effect. That’s the main reason to utilize nanoparticles in cancer therapy. Besides, the size, shape, surface chemistry and targeting groups of nanoparticles are important in controlling biodistribution and cellular internalization of engineered nanoparticles. Zein specifically acts as reservoirs for lipophilic bioactive substances or drugs due to the strong hydrogen bond and hydrophobic interaction between nutraceutical and proteins. Zein nanoparticles (NPs) are commonly prepared via phase separation method. Although it is a relatively easy technique, the resultant zein colloidal dispersion usually form poorly redispersable aggregates and sediments after drying. Also, individual zein NPs exhibited a burst drug release profile at physiological conditions due to the swelling of the zein NPs and the drug cannot tightly bind to zein particles. Therefore, we aim to design novel zein-based NPs to enhance the stability and sustained release of individual zein NPs. At the meantime, the cellular uptake and bioefficacy of the encapsulated drug were also discussed in this work. In the first part of this work, hydrophilic carboxymethyl konjac glucomannan and calcium ion crosslinking were used to modify the surface of zein nanoparticles, therefore zein- carboxymethyl konjac glucomannan-calcium (ZCC) NPs were assembled. As a result, ZCC NPs showed good stabilities in cell culture medium at 37 °C, and enhanced pH stability at a range from 5.0 to 8.5 and lower surface hydrophobicity. The endocytic pathway of ZCC NPs is cell-line dependent, and ZCC NPs enhanced the cellular uptake through dynamin- mediated endocytosis can be assigned to clathrin-mediated endocytosis in HT29 cells. And the stability and cellular uptake were enhanced compared to individual zein NPs. Because of the anti-inflammation and anti-cancer properties, andrographolide (AG) and its derivatives, which are labdane diterpenoid compounds extracted from Andrographis paniculata Nees, are often used as herbal drugs in Asian countries. AG sparingly soluble in water (3.29μg/ml at 25 °C), which restricts its therapeutic use due to low bioavailability by oral administration. ZCC NPs was used as a drug carrier for AG to enhance the water solubility and the bioefficacy. Importantly, ZCC NPs loaded AG were shown effectively decreasing the cancer cell population and resulting cell death. The efficacy of AG to regulate the in vitro NF-κB expression was notably enhanced by the ZCC nanoparticle delivery system due to enhanced dose efficiency resulting from better solubility, transportability and reduced toxicity. In these preliminary studies, ZCC NPs were proved to be appealing delivery systems for hydrophobic bioactive compounds. Efficient pH-sensitive delivery systems sensitively… Advisors/Committee Members: HUANG, QINGRONG (chair), HO, CHI-TANG (internal member), Wu, Qing-Li (internal member), Zheng, Xi (outside member), School of Graduate Studies.

Subjects/Keywords: Cancer – Treatment; Nanomedicine

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APA (6^th Edition):

Zhu, Xunan, 1. (2019). Design of self-assembled zein-based nanoparticles as an effective drug carrier and transporter. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/60120/

Chicago Manual of Style (16^th Edition):

Zhu, Xunan, 1991-. “Design of self-assembled zein-based nanoparticles as an effective drug carrier and transporter.” 2019. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/60120/.

MLA Handbook (7^th Edition):

Zhu, Xunan, 1991-. “Design of self-assembled zein-based nanoparticles as an effective drug carrier and transporter.” 2019. Web. 16 Jan 2021.

Vancouver:

Zhu, Xunan 1. Design of self-assembled zein-based nanoparticles as an effective drug carrier and transporter. [Internet] [Doctoral dissertation]. Rutgers University; 2019. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/60120/.

Council of Science Editors:

Zhu, Xunan 1. Design of self-assembled zein-based nanoparticles as an effective drug carrier and transporter. [Doctoral Dissertation]. Rutgers University; 2019. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/60120/

Universiteit Utrecht

11. Yilmaz, V. Cancer Immunotherapy.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/253742

► Cancer is the leading cause of death in economically developed countries and the conventional anti-cancer therapies fail to meet the criteria of an ideal, safe… (more)

Subjects/Keywords: Cancer; Immunotherapy; cancer immunology; cancer treatment

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APA (6^th Edition):

Yilmaz, V. (2012). Cancer Immunotherapy. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/253742

Chicago Manual of Style (16^th Edition):

Yilmaz, V. “Cancer Immunotherapy.” 2012. Masters Thesis, Universiteit Utrecht. Accessed January 16, 2021. http://dspace.library.uu.nl:8080/handle/1874/253742.

MLA Handbook (7^th Edition):

Yilmaz, V. “Cancer Immunotherapy.” 2012. Web. 16 Jan 2021.

Vancouver:

Yilmaz V. Cancer Immunotherapy. [Internet] [Masters thesis]. Universiteit Utrecht; 2012. [cited 2021 Jan 16]. Available from: http://dspace.library.uu.nl:8080/handle/1874/253742.

Council of Science Editors:

Yilmaz V. Cancer Immunotherapy. [Masters Thesis]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/253742

12. Elango, J Kalavathy. Risk profile of oral cancers and strategies to improve awareness and early detection.

Degree: 2009, Amrita Vishwa Vidyapeetham (University)

URL: http://shodhganga.inflibnet.ac.in/handle/10603/2363

►

Fundamentals of implementing any cancer control programs are the understanding of the burden of the disease in the community (incidence trends), risk factor profile and… (more)

Subjects/Keywords: Oral cancer; Oncology; Cancer prevention; Cancer treatment

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APA (6^th Edition):

Elango, J. K. (2009). Risk profile of oral cancers and strategies to improve awareness and early detection. (Thesis). Amrita Vishwa Vidyapeetham (University). Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/2363

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Elango, J Kalavathy. “Risk profile of oral cancers and strategies to improve awareness and early detection.” 2009. Thesis, Amrita Vishwa Vidyapeetham (University). Accessed January 16, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/2363.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Elango, J Kalavathy. “Risk profile of oral cancers and strategies to improve awareness and early detection.” 2009. Web. 16 Jan 2021.

Vancouver:

Elango JK. Risk profile of oral cancers and strategies to improve awareness and early detection. [Internet] [Thesis]. Amrita Vishwa Vidyapeetham (University); 2009. [cited 2021 Jan 16]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2363.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Elango JK. Risk profile of oral cancers and strategies to improve awareness and early detection. [Thesis]. Amrita Vishwa Vidyapeetham (University); 2009. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2363

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas – Austin

13. -7281-1935. Life cycle cost analysis for cancer patients at the University of Texas MD Anderson Cancer Center.

Degree: MSin Engineering, Operations Research & Industrial Engineering, 2018, University of Texas – Austin

URL: http://hdl.handle.net/2152/67516

► Healthcare costs can be astronomical when it comes to cancer treatment. Given the steep costs of treatment, it is expected for a patient to learn… (more)

Subjects/Keywords: Healthcare; Cancer; Revenue cycle; Cancer treatment costs; Cancer treatment cost estimates; Cancer treatment cost factors; Cancer treatment cost prediction; Cancer treatment cost analysis; MD Anderson Cancer Center

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APA (6^th Edition):

-7281-1935. (2018). Life cycle cost analysis for cancer patients at the University of Texas MD Anderson Cancer Center. (Masters Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/67516

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

-7281-1935. “Life cycle cost analysis for cancer patients at the University of Texas MD Anderson Cancer Center.” 2018. Masters Thesis, University of Texas – Austin. Accessed January 16, 2021. http://hdl.handle.net/2152/67516.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

-7281-1935. “Life cycle cost analysis for cancer patients at the University of Texas MD Anderson Cancer Center.” 2018. Web. 16 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

-7281-1935. Life cycle cost analysis for cancer patients at the University of Texas MD Anderson Cancer Center. [Internet] [Masters thesis]. University of Texas – Austin; 2018. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/2152/67516.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

-7281-1935. Life cycle cost analysis for cancer patients at the University of Texas MD Anderson Cancer Center. [Masters Thesis]. University of Texas – Austin; 2018. Available from: http://hdl.handle.net/2152/67516

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

University of Illinois – Chicago

14. Silva, Abigail. Assessing Racial/Ethnic Disparities along the Breast Cancer Treatment Continuum.

Degree: 2013, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/10353

► Ensuring equitable adjuvant treatment may alleviate the racial disparity in breast cancer mortality; yet little is known about factors that facilitate or impede treatment. This… (more)

▼ Ensuring equitable adjuvant treatment may alleviate the racial disparity in breast cancer mortality; yet little is known about factors that facilitate or impede treatment. This study assesses and examines racial/ethnic disparities in adjuvant breast cancer treatment offered, accepted, and initiated. The primary data came from a population-based study that included 989 females living in Chicago, age 30 to 79 years, who were diagnosed with first primary breast cancer in 2005–2008. Logistic regression using model-based standardization was used to estimate age-adjusted risk differences and path analyses were conducted to help explain the disparities. Chemotherapy treatment (CT) guidelines changed during the study period, and the association between race/ethnicity and treatment differed depending on which guideline was used to determine CT-eligibility. Among those for whom CT became discretionary, minority patients were more likely than non-Hispanic (nH) White patients to receive a CT recommendation but this was largely explained by tumor differences. There were no discernible racial/ethnic differences in radiation treatment (RT) recommendation and acceptance. However, among all RT-eligible patients, minority patients were less likely than nH White patients to receive RT (0.75 versus 0.74, p=0.01). This was explained by the higher use of mastectomy and lower breast tumor knowledge among minority patients. Compared to nH White patients (0.94), minority patients (0.80) were less likely to receive a recommendation for hormonal treatment (p=0.00). Tumor knowledge appears to be an important contributor of this disparity as well. Mastectomy patients may not be receiving guideline-adherent RT. In addition, a patient’s breast tumor knowledge may be protective against treatment underuse. These may present important avenues for disparity-reducing interventions. Advisors/Committee Members: Rauscher, Garth H. (advisor), Ferrans, Carol E. (committee member), Hoskins, Kent (committee member), Rao, Ruta (committee member), Campbell, Richard T. (committee member).

Subjects/Keywords: treatment; breast cancer; disparity

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APA (6^th Edition):

Silva, A. (2013). Assessing Racial/Ethnic Disparities along the Breast Cancer Treatment Continuum. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/10353

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Silva, Abigail. “Assessing Racial/Ethnic Disparities along the Breast Cancer Treatment Continuum.” 2013. Thesis, University of Illinois – Chicago. Accessed January 16, 2021. http://hdl.handle.net/10027/10353.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Silva, Abigail. “Assessing Racial/Ethnic Disparities along the Breast Cancer Treatment Continuum.” 2013. Web. 16 Jan 2021.

Vancouver:

Silva A. Assessing Racial/Ethnic Disparities along the Breast Cancer Treatment Continuum. [Internet] [Thesis]. University of Illinois – Chicago; 2013. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10027/10353.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silva A. Assessing Racial/Ethnic Disparities along the Breast Cancer Treatment Continuum. [Thesis]. University of Illinois – Chicago; 2013. Available from: http://hdl.handle.net/10027/10353

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Catholique de Louvain

15. Barragan Montero, Ana Maria. Robust, accurate and patient-specific treatment planning for proton therapy.

Degree: 2017, Université Catholique de Louvain

URL: http://hdl.handle.net/2078.1/189076

►

The survival statistics for cancer patients treated with radiation therapy using photon beams show that many treatments fail due to poor tumour local control (TLC).… (more)

Subjects/Keywords: Proton therapy; Cancer treatment planning

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APA (6^th Edition):

Barragan Montero, A. M. (2017). Robust, accurate and patient-specific treatment planning for proton therapy. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/189076

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Barragan Montero, Ana Maria. “Robust, accurate and patient-specific treatment planning for proton therapy.” 2017. Thesis, Université Catholique de Louvain. Accessed January 16, 2021. http://hdl.handle.net/2078.1/189076.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Barragan Montero, Ana Maria. “Robust, accurate and patient-specific treatment planning for proton therapy.” 2017. Web. 16 Jan 2021.

Vancouver:

Barragan Montero AM. Robust, accurate and patient-specific treatment planning for proton therapy. [Internet] [Thesis]. Université Catholique de Louvain; 2017. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/2078.1/189076.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Barragan Montero AM. Robust, accurate and patient-specific treatment planning for proton therapy. [Thesis]. Université Catholique de Louvain; 2017. Available from: http://hdl.handle.net/2078.1/189076

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

16. Zhong, Jieying. Membrane lytic peptide-based molecular therapeutic for targeted anticancer treatment.

Degree: 2012, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-7637 ; https://doi.org/10.14711/thesis-b1176699 ; http://repository.ust.hk/ir/bitstream/1783.1-7637/1/th_redirect.html

► Membrane lytic peptides are a novel class of anticancer agents which have the potential to overcome drug resistance. We aim to improve the selectivity, potency… (more)

▼ Membrane lytic peptides are a novel class of anticancer agents which have the potential to overcome drug resistance. We aim to improve the selectivity, potency and pharmacokinetic profile of membrane lytic peptides in anticancer treatment and explore the underlying mechanism in this work. The first part is focused on selectivity mediated by tumor-associated protease. An 18 residue membrane lytic peptide was cyclized with a linker cleavable by tumor overexpressed MT1-MMP. The activity of peptide was suppressed upon cyclization and could be recovered upon enzymatic digestion. And MT1-MMP-positive cells were preferentially killed by the peptide. In the second part, we tried to improve the pharmacokinetic performance of lytic peptide with the strategy of polyvalency and polymeric therapeutics. A short amphipathic sequence (KW)3 was conjugated to dextran in multiple copies to afford a polyvalent conjugate Dex-(KW)3. The conjugate exhibited 500-fold potency enhancement compared to monomeric (KW)3 in MTT assay. No hemolytic activity was detected. Thermodynamic study revealed stronger membrane binding and deeper membrane penetration of Dex-(KW)3, which were attributed to the high local concentration of peptides on a nano-sized carrier. We further investigated the mechanism of how the conjugate affects cancer cells in the third part of this work. The membrane integrity and metabolic activity of cells were examined at different concentrations of conjugate. Membrane damage occurred at high concentration range. The decrease of metabolic activity began at low concentration when the plasma membrane was still intact. A dual-function mechanism was proposed and proven with a polyelectrolyte complex between Dex-(KW)3 and poly-γ-glutamic acid (PGA). The complexation neutralized the positive charge of Dex-(KW)3 and efficiently suppressed the plasma membrane lysing activity. But it did not change the intracellular activity of conjugate, namely decreasing the cell metabolic activity and mitochondrial membrane potential. We hypothesized the complex Dex-(KW)3/PGA was internalized and dissociate in the acidic environment of endosome. And it was supported by thermodynamic study, in which weaker binding between conjugate and PGA at pH 5.5 than at pH 7.4 was found. The complexation inhibited the effect on plasma membrane while maintained the intracellular activity. The strategy separates one effect from the other thus allows better understanding and control of the novel conjugate.

Subjects/Keywords: Peptides – Therapeutic use ; Cancer – Treatment

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APA (6^th Edition):

Zhong, J. (2012). Membrane lytic peptide-based molecular therapeutic for targeted anticancer treatment. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-7637 ; https://doi.org/10.14711/thesis-b1176699 ; http://repository.ust.hk/ir/bitstream/1783.1-7637/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhong, Jieying. “Membrane lytic peptide-based molecular therapeutic for targeted anticancer treatment.” 2012. Thesis, Hong Kong University of Science and Technology. Accessed January 16, 2021. http://repository.ust.hk/ir/Record/1783.1-7637 ; https://doi.org/10.14711/thesis-b1176699 ; http://repository.ust.hk/ir/bitstream/1783.1-7637/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhong, Jieying. “Membrane lytic peptide-based molecular therapeutic for targeted anticancer treatment.” 2012. Web. 16 Jan 2021.

Vancouver:

Zhong J. Membrane lytic peptide-based molecular therapeutic for targeted anticancer treatment. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2012. [cited 2021 Jan 16]. Available from: http://repository.ust.hk/ir/Record/1783.1-7637 ; https://doi.org/10.14711/thesis-b1176699 ; http://repository.ust.hk/ir/bitstream/1783.1-7637/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhong J. Membrane lytic peptide-based molecular therapeutic for targeted anticancer treatment. [Thesis]. Hong Kong University of Science and Technology; 2012. Available from: http://repository.ust.hk/ir/Record/1783.1-7637 ; https://doi.org/10.14711/thesis-b1176699 ; http://repository.ust.hk/ir/bitstream/1783.1-7637/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

17. Fipaza, Vincent Lukhanyiso. The development of functionalized metallic nanoparticles for the treatment of brain cancer .

Degree: 2019, University of the Western Cape

URL: http://hdl.handle.net/11394/7140

► Cancers of the nervous system often result from abnormal and uncontrolled growth of cells in nervous tissue. Glioblastoma Multiforme (GBM) and neuroblastoma (NB) are among… (more)

Subjects/Keywords: Nanoparticles; PEGylation; Cancer; Treatment; Cytotoxicity

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APA (6^th Edition):

Fipaza, V. L. (2019). The development of functionalized metallic nanoparticles for the treatment of brain cancer . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/7140

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fipaza, Vincent Lukhanyiso. “The development of functionalized metallic nanoparticles for the treatment of brain cancer .” 2019. Thesis, University of the Western Cape. Accessed January 16, 2021. http://hdl.handle.net/11394/7140.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fipaza, Vincent Lukhanyiso. “The development of functionalized metallic nanoparticles for the treatment of brain cancer .” 2019. Web. 16 Jan 2021.

Vancouver:

Fipaza VL. The development of functionalized metallic nanoparticles for the treatment of brain cancer . [Internet] [Thesis]. University of the Western Cape; 2019. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/11394/7140.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fipaza VL. The development of functionalized metallic nanoparticles for the treatment of brain cancer . [Thesis]. University of the Western Cape; 2019. Available from: http://hdl.handle.net/11394/7140

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

18. Karsli Uzunbas, Gizem, 1984-. Autophagy in tissue homeostasis and cancer.

Degree: PhD, Homeostasis, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/46502/

►

Macroautophagy (autophagy hereafter) is a protective process that recycles cellular components to maintain homeostasis and survival. By removing damaged protein and organelles, autophagy ensures protein… (more)

▼

Macroautophagy (autophagy hereafter) is a protective process that recycles cellular components to maintain homeostasis and survival. By removing damaged protein and organelles, autophagy ensures protein and organelle quality control. In cancer, the role of autophagy is context dependent. Autophagy is an essential survival mechanism during starvation that promotes tumor progression, but there are also cases where autophagy can suppress tumorigenesis in mouse models. Thus, understanding the role of autophagy modulation in cancer is critical for cancer therapy. Tumors with RAS mutations require autophagy to tolerate metabolic stress, suggesting that autophagy inhibition may be a potential approach in cancer therapy. However, how systemic autophagy inactivation differentially affects normal and tumor tissues is unknown. To assess the functional significance of autophagy, we conditionally deleted the essential autophagy gene, Atg7, throughout adult mice. In that way, we could model the consequences of autophagy inactivation simultaneously to both normal and tumor tissue to simulate autophagy inhibition in cancer therapy. First, we wanted to identify what happens to an adult mouse when autophagy is turned off. We generated a mouse model to delete Atg7, throughout the entire mouse to determine the role of autophagy in adult mammal. Systemic ATG7 ablation caused susceptibility to infection and neurodegeneration that limited survival to 2-3 months. Moreover, autophagy was required to maintain fat stores and to mobilize free fatty acids specifically in response to fasting. Also, upon fasting, autophagy-deficient mice suffered muscle wasting and fatal hypoglycemia that is mediated by p53. Not only limited to the starvation stress response, inhibiting autophagy also increased sensitivity to γ-irradiation-induced death. Second, knowing that there is a window of time that adult mice can survive without autophagy, we examined if autophagy ablation is selectively toxic to tumors while sparing normal tissues. For this purpose, we generated another mouse model to induce non-small-cell lung cancer (NSCLC) and then prior to or once tumors were established, we acutely ablated autophagy. Prior autophagy ablation did not alter the efficiency of NSCLC initiation by activation of oncogenic KrasG12D and deletion of the Trp53 tumor suppressor. Acute autophagy ablation in mice with pre-existing NSCLC, however, blocked tumor growth, promoted tumor cell death, and generated more benign cancer with oncocytic changes. Moreover, host autophagy contributed to tumor growth. This anti-tumor activity occurred prior to destruction of normal tissues, suggesting that, acute autophagy inhibition may be therapeutically beneficial in cancer.

Advisors/Committee Members: White, Eileen (chair), JIN, SHENGKAN (VICTOR) (internal member), Karantza, Vassiliki (internal member), RABINOWITZ, JOSHUA (outside member), Xia, Bing (outside member).

Subjects/Keywords: Tumors; Cancer – Treatment; Biochemistry

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APA (6^th Edition):

Karsli Uzunbas, Gizem, 1. (2015). Autophagy in tissue homeostasis and cancer. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/46502/

Chicago Manual of Style (16^th Edition):

Karsli Uzunbas, Gizem, 1984-. “Autophagy in tissue homeostasis and cancer.” 2015. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/46502/.

MLA Handbook (7^th Edition):

Karsli Uzunbas, Gizem, 1984-. “Autophagy in tissue homeostasis and cancer.” 2015. Web. 16 Jan 2021.

Vancouver:

Karsli Uzunbas, Gizem 1. Autophagy in tissue homeostasis and cancer. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/46502/.

Council of Science Editors:

Karsli Uzunbas, Gizem 1. Autophagy in tissue homeostasis and cancer. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/46502/

University of Windsor

19. Stanesic, Michael. Assessing the Anticancer Potential of Natural Health Products (Lemongrass, Hibiscus, and Eleuthero Ginseng) Against Breast Cancer Models.

Degree: MS, Chemistry and Biochemistry, 2017, University of Windsor

URL: https://scholar.uwindsor.ca/etd/6017

► Breast cancer is a growing problem worldwide. Currently used cancer therapy is effective against cancer, but also causes cell death in normal cells, thereby causing… (more)

Subjects/Keywords: Cancer; Natural Health Products; Treatment

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APA (6^th Edition):

Stanesic, M. (2017). Assessing the Anticancer Potential of Natural Health Products (Lemongrass, Hibiscus, and Eleuthero Ginseng) Against Breast Cancer Models. (Masters Thesis). University of Windsor. Retrieved from https://scholar.uwindsor.ca/etd/6017

Chicago Manual of Style (16^th Edition):

Stanesic, Michael. “Assessing the Anticancer Potential of Natural Health Products (Lemongrass, Hibiscus, and Eleuthero Ginseng) Against Breast Cancer Models.” 2017. Masters Thesis, University of Windsor. Accessed January 16, 2021. https://scholar.uwindsor.ca/etd/6017.

MLA Handbook (7^th Edition):

Stanesic, Michael. “Assessing the Anticancer Potential of Natural Health Products (Lemongrass, Hibiscus, and Eleuthero Ginseng) Against Breast Cancer Models.” 2017. Web. 16 Jan 2021.

Vancouver:

Stanesic M. Assessing the Anticancer Potential of Natural Health Products (Lemongrass, Hibiscus, and Eleuthero Ginseng) Against Breast Cancer Models. [Internet] [Masters thesis]. University of Windsor; 2017. [cited 2021 Jan 16]. Available from: https://scholar.uwindsor.ca/etd/6017.

Council of Science Editors:

Stanesic M. Assessing the Anticancer Potential of Natural Health Products (Lemongrass, Hibiscus, and Eleuthero Ginseng) Against Breast Cancer Models. [Masters Thesis]. University of Windsor; 2017. Available from: https://scholar.uwindsor.ca/etd/6017

University of Limerick

20. Kiely, Maeve. RACK1 facilitates the activity and substrate specificity of PP2A in breast cancer cells.

Degree: 2014, University of Limerick

URL: http://hdl.handle.net/10344/5059

►

peer-reviewed

Breast cancer is a leading cause of cancer death worldwide but targeted therapies have proven to be very successful in the treatment of this… (more)

▼

peer-reviewed

Breast cancer is a leading cause of cancer death worldwide but targeted therapies have proven to be very successful in the treatment of this disease. The aim of this study was to develop models and parameters that will help identify potential therapeutic targets and strategies for breast cancer treatment. We utilized the RTCA xCELLigence platform to develop protocols and determine the effect of novel compounds on breast cancer cells. We found that the vitamin K (VK) derivative, VK2 reduced the viability of Triple Negative Breast Cancer (TNBC) cells. Culturing the cells in media with a combination of VK2 and low glucose shows a further reduction in cell viability. This contributes to the body of knowledge about the benefits of calorie restriction (CR) in cancer patients. Using the platforms and parameters we developed, we expanded our study to investigate the effects of PRIMA1Met on cancer cell behaviour. PRIMA1Met is a small molecule that can revert mutant p53 back to Wild Type. Treatment of a panel of breast cancer cell lines with PRIMA1Met showed cell lines with mutant p53 were sensitive to the molecule. These results correlated very well with more traditional cell based assays. This is the first known analysis of breast cancer cells treated with either VK2 or PRIMA1Met conducted in real time. We next characterised the interaction between RACK1 and PP2A in order to identify a possible role for the complex in breast cancer cells. It is known that RACK1 and PP2A bind directly in an IGF-1 dependant manner and play a role in cell migration. We confirmed that RACK1 was in a complex with both the PP2A C and A subunits. Mutation of the interaction sites between RACK1 and the PP2A C subunit allowed us to determine the consequences for disruption of the complex. Using stable cell lines expressing the mutant subtype, we showed that the RACK1/PP2A complex plays a role iv in the progression of many important cellular processes including adhesion, proliferation, migration and invasion. It also plays a role in maintenance of the cancer phenotype. We hypothesized that RACK1 was scaffolding PP2A to a novel set of substrates through its role as a signalling hub. To identify novel interacting proteins of the RACK1/PP2A complex we isolated the complex from breast cancer cells and used mass spectrometry to identify 66 novel binding partners of the complex. Our aim was to characterise some of these proteins with a particular focus on those involved in cancer. We chose Tau Tubulin Kinase-1 (TTBK-1) and Metadherin for further study and we suggest that TTBK-1 has the potential to be a prognostic indicator of disease. Gene expression analysis identified Metadherin to be upregulated in a cohort of breast cancer patient samples. We confirmed the interaction between Metadherin and the RACK1/PP2A complex and mapped potential binding sites for RACK1 on Metadherin. These findings confirm the direct interaction between RACK1 and PP2A and are the first to characterise the interaction between these proteins in cancer cells.…

Advisors/Committee Members: Kiely, Patrick, Irish Cancer Society.

Subjects/Keywords: breast cancer; treatment; PP2A; RACK1

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kiely, M. (2014). RACK1 facilitates the activity and substrate specificity of PP2A in breast cancer cells. (Thesis). University of Limerick. Retrieved from http://hdl.handle.net/10344/5059

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kiely, Maeve. “RACK1 facilitates the activity and substrate specificity of PP2A in breast cancer cells.” 2014. Thesis, University of Limerick. Accessed January 16, 2021. http://hdl.handle.net/10344/5059.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kiely, Maeve. “RACK1 facilitates the activity and substrate specificity of PP2A in breast cancer cells.” 2014. Web. 16 Jan 2021.

Vancouver:

Kiely M. RACK1 facilitates the activity and substrate specificity of PP2A in breast cancer cells. [Internet] [Thesis]. University of Limerick; 2014. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10344/5059.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kiely M. RACK1 facilitates the activity and substrate specificity of PP2A in breast cancer cells. [Thesis]. University of Limerick; 2014. Available from: http://hdl.handle.net/10344/5059

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Massey University

21. Tapper, Karen Anne. Men, prostate cancer and complementary and alternative medicine : a narrative inquiry.

Degree: MS, Psychology, 2014, Massey University

URL: http://hdl.handle.net/10179/10688

► Cancer is the most feared illness in Western societies. Yet remarkable medical advances are being made that extend life-spans that once would have been cut… (more)

▼ Cancer is the most feared illness in Western societies. Yet remarkable medical advances are being made that extend life-spans that once would have been cut short by cancer. Prostate cancer is now a chronic disease in most cases. However in many cases medical treatment of a slowly progressing disease has left men with undesirable sequelae of treatment, such as impotence and urinary incontinence. Psychosocial research into prostate cancer has tended to concentrate on questions related to these side-effects of treatment. This research investigates a different aspect of prostate cancer; the use of complementary and alternative medicine (CAM) by men with prostate cancer. It is a qualitative narrative inquiry that investigates the stories of six men, all diagnosed with this condition and all using CAM, either in a complementary sense or as an alternative to biomedical treatment. They ranged in time since diagnosis from two months to 17 years. The narrative account is divided into three sections; the first explores causal narratives, the second explores narratives of diagnosis with prostate cancer, and the third section examines narratives of treatment, both CAM and biomedical. It contributes to the understanding of how men with prostate cancer negotiate the phases of their illness and actively integrate CAM and biomedical narratives, treatments and practices. The production of positions consistent with culturally dominant masculine values is shown to be a part of this negotiation. The finding of 'sensitising events' that predisposed men to using CAM is discussed. Men with prostate cancer negotiate complex dialectics between their quantity of life and their quality of life and between active agency in their own healing and being a patient. The clinical relationship with both physicians and CAM persons is very important in ensuring that men make treatment decisions with full information and support. Implications of the findings and future research possibilities are discussed.

Subjects/Keywords: Prostate cancer; Patients; Alternative treatment

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APA (6^th Edition):

Tapper, K. A. (2014). Men, prostate cancer and complementary and alternative medicine : a narrative inquiry. (Masters Thesis). Massey University. Retrieved from http://hdl.handle.net/10179/10688

Chicago Manual of Style (16^th Edition):

Tapper, Karen Anne. “Men, prostate cancer and complementary and alternative medicine : a narrative inquiry.” 2014. Masters Thesis, Massey University. Accessed January 16, 2021. http://hdl.handle.net/10179/10688.

MLA Handbook (7^th Edition):

Tapper, Karen Anne. “Men, prostate cancer and complementary and alternative medicine : a narrative inquiry.” 2014. Web. 16 Jan 2021.

Vancouver:

Tapper KA. Men, prostate cancer and complementary and alternative medicine : a narrative inquiry. [Internet] [Masters thesis]. Massey University; 2014. [cited 2021 Jan 16]. Available from: http://hdl.handle.net/10179/10688.

Council of Science Editors:

Tapper KA. Men, prostate cancer and complementary and alternative medicine : a narrative inquiry. [Masters Thesis]. Massey University; 2014. Available from: http://hdl.handle.net/10179/10688

Rutgers University

22. Ibrahim, Sherif, 1981-. Evaluation of a camptothecin/sodium-R-alpha lipoate combination for the treatment of non-small cell lung cancer.

Degree: PhD, Pharmaceutical Science, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/47732/

►

Lung cancer is the most common cause of cancer-related mortality among both men and women in the United States and worldwide, killing more people than… (more)

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Lung cancer is the most common cause of cancer-related mortality among both men and women in the United States and worldwide, killing more people than breast, prostate, and colon cancers combined. It is estimated that 1.37 million people worldwide die of the disease annually. Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases worldwide and thus remains a primary focus of therapeutic lung cancer research. Currently used treatments for NSCLC include surgery, chemotherapy, radiotherapy, and targeted/biological therapy. Despite these treatment options, the disease remains a considerable cause of morbidity and mortality. Thus, more effective treatment options are highly sought after. NSCLC is most often diagnosed at late stages, at which time surgery can no longer offer a curative outcome. Thus, cytotoxic chemotherapy remains the first-line treatment for late-stage NSCLC. However, efficacy has been modest at best and toxicity remains a significant drawback. Improvements to current chemotherapeutic strategies are direly needed. The objective of this thesis is to evaluate a combination of camptothecin (CPT) and sodium-R-alpha lipoate (Na-RALA) for the treatment of NSCLC. Using a variety of concentration- and time-dependent in vitro assays, we found that a combination of CPT and Na-RALA: 1) exerted additive/synergistic cytotoxic effects against A549 human NSCLC adenocarcinoma cells; 2) has higher efficacy, higher cancer-selectivity, and lower toxicity towards normal cells than CPT alone; 3) simultaneously targets multiple hallmarks of cancer, including migration, invasion, senescence, and angiogenesis, and thus has the potential to reduce metastasis and general progression of NSCLC. In vivo evaluation of the combination began with the development of an orthotopic xenograft NSCLC model. The intrathoracic (IT) and intracardiac (IC) mouse models of NSCLC were deemed most fitting for our study design and objectives. A combination of CPT and Na-RALA deserves further evaluation as a treatment for NSCLC.

Advisors/Committee Members: Sinko, Patrick (chair), Colaizzi, John L. (internal member), Suh, Nanjoo (internal member), Prud'homme, Robert (outside member).

Subjects/Keywords: Lungs – Cancer – Treatment; Camptothecin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ibrahim, Sherif, 1. (2015). Evaluation of a camptothecin/sodium-R-alpha lipoate combination for the treatment of non-small cell lung cancer. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/47732/

Chicago Manual of Style (16^th Edition):

Ibrahim, Sherif, 1981-. “Evaluation of a camptothecin/sodium-R-alpha lipoate combination for the treatment of non-small cell lung cancer.” 2015. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/47732/.

MLA Handbook (7^th Edition):

Ibrahim, Sherif, 1981-. “Evaluation of a camptothecin/sodium-R-alpha lipoate combination for the treatment of non-small cell lung cancer.” 2015. Web. 16 Jan 2021.

Vancouver:

Ibrahim, Sherif 1. Evaluation of a camptothecin/sodium-R-alpha lipoate combination for the treatment of non-small cell lung cancer. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47732/.

Council of Science Editors:

Ibrahim, Sherif 1. Evaluation of a camptothecin/sodium-R-alpha lipoate combination for the treatment of non-small cell lung cancer. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/47732/

Rutgers University

23. Wahler, Joseph, 1987-. Inhibition of breast cancer progression with Vitamin D compounds.

Degree: PhD, Pharmacology, Cellular and Molecular, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48709/

►

Early epidemiological studies have shown an inverse correlation of increased vitamin D3 to breast cancer. Since this discovery, many studies have linked 1,25-dihydroxyvitamin D3, the… (more)

▼

Early epidemiological studies have shown an inverse correlation of increased vitamin D3 to breast cancer. Since this discovery, many studies have linked 1,25-dihydroxyvitamin D3, the active metabolite of vitamin D, and vitamin D analogs to decreased cell proliferation, invasion, and metastasis. The pharmacological dose of 1,25(OH)2D3 required to elicit a response can induce hypercalcemic toxicity. Therefore, non-calcemic vitamin D analogs, such as BXL0124, have been of interest in the inhibition of breast cancer. Breast cancer is a heterogeneous disease which proceeds through a natural progression, beginning with early hyperplasia and culminating in invasive or metastatic disease. Ductal carcinoma in situ (DCIS) is a non-malignant lesion of the breast with the potential to progress to invasive ductal carcinoma (IDC). Due to the implications of breast cancer stem cells (BCSCs) in breast cancer progression, we investigated the role of vitamin D compounds on these processes. We showed that BXL0124 inhibited the progression of DCIS to IDC in a model of breast cancer progression by maintaining critical DCIS structures through the modulation of matrix metalloproteinases transcription. In addition, BXL0124 treatment decreased cell proliferation and maintained vitamin D receptor (VDR) levels in tumors. VDR was expressed in a variety of clinical breast tumors and was lost during malignant transformation of normal mammary cells to pre-malignant histological types, suggesting vitamin D supplementation as a preventative agent due to higher VDR levels in normal breast tissue. Vitamin D compounds (125(OH)2D3 or BXL0124) reduced the growth and self-renewal of mammospheres, an assay which enriches for BCSCs. The putative CD44+/CD24-/low BCSC population was shifted to a population expressing higher CD24 in vitro and in vivo by treatment with BXL0124. Pluripotency genes such as CD44 and OCT4 were also repressed, contributing to the reduction in cell and tumor growth. We demonstrated the therapeutic potential of Gemini vitamin D analog BXL0124 on the inhibition of breast cancer progression and the ability of vitamin D compounds to repress the BCSC population in vitro and in vivo, potentially contributing to the effects on tumor progression.

Advisors/Committee Members: Suh, Nanjoo (chair), Chen, Suzie (internal member), Cai, Li (internal member), Liu, Fang (internal member), Cohick, Wendie (outside member).

Subjects/Keywords: Breast – Cancer – Treatment; Vitamin D

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wahler, Joseph, 1. (2015). Inhibition of breast cancer progression with Vitamin D compounds. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48709/

Chicago Manual of Style (16^th Edition):

Wahler, Joseph, 1987-. “Inhibition of breast cancer progression with Vitamin D compounds.” 2015. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/48709/.

MLA Handbook (7^th Edition):

Wahler, Joseph, 1987-. “Inhibition of breast cancer progression with Vitamin D compounds.” 2015. Web. 16 Jan 2021.

Vancouver:

Wahler, Joseph 1. Inhibition of breast cancer progression with Vitamin D compounds. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48709/.

Council of Science Editors:

Wahler, Joseph 1. Inhibition of breast cancer progression with Vitamin D compounds. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48709/

Rutgers University

24. Karjoo Diarkhan, Zahra, 1980-. Customization and optimization of a histone h2a-based vector for targeted gene transfer to cancer cells.

Degree: PhD, Pharmaceutical Science, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/46367/

►

Developing an efficient and safe system for gene delivery is considered the bottleneck of gene therapy, where a successful delivery of the nucleic acid can… (more)

▼

Developing an efficient and safe system for gene delivery is considered the bottleneck of gene therapy, where a successful delivery of the nucleic acid can reverse a defective cellular pathway to normal, eradicate cancer at molecular level or simply make it more susceptible to current chemotherapies. Not only have the intracellular events played a crucial role for obtaining a successful gene delivery, but the interaction of nano-particles with extracellular factors should be studied as well. The goal of this study was to design, produce and optimize a non-viral gene delivery system for targeted delivery of nucleic acid such as reporter genes (e.g., green fluorescent protein) or therapeutic genes (e.g., suicide genes) to cancer cells. The system was designed in a way to be easily customized for different cancer types, still presenting a high level of targeted delivery. The first chapter of this thesis will focus on the concept of gene therapy and current systems used for this modality. Different types of vectors including viral and non-viral polymeric vectors will be discussed briefly and the advantages and disadvantages of each will be mentioned. We also discussed natured inspired biopolymers such as peptides and amino acid based vectors which are the fundamental premise of this study. In chapter II, the concept of suicide gene therapy will be explained. Additionally, the current enzyme/prodrug systems, different methods for delivery of suicide genes will be elaborated. In chapter III and IV, the new nanotechnology platform for targeted delivery of plasmid DNA to HER2-positive ovarian cancer cells and HER2-negative prostate cancer cells will be presented. In chapter III, the method for optimization of nanotechnology platform will be discussed and the features of optimized particles will be presented. Chapter IV explains the modification we introduced to the vectors’ primary structure to customize it for a different cell line. Also another method for optimization of amino-acid based vectors for in vivo delivery will be introduced. In these two chapters, the methods of designing and the efficiency of each vector to fulfill the expected goals as well as their safety will be discussed in details and supportive data will be presented.

Advisors/Committee Members: Hatefi, Arash (chair), Minko, Tamara (internal member), You, Guofeng (internal member), GOW, ANDREW (outside member).

Subjects/Keywords: Gene therapy; Cancer – Treatment; Nanoparticles

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Karjoo Diarkhan, Zahra, 1. (2015). Customization and optimization of a histone h2a-based vector for targeted gene transfer to cancer cells. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/46367/

Chicago Manual of Style (16^th Edition):

Karjoo Diarkhan, Zahra, 1980-. “Customization and optimization of a histone h2a-based vector for targeted gene transfer to cancer cells.” 2015. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/46367/.

MLA Handbook (7^th Edition):

Karjoo Diarkhan, Zahra, 1980-. “Customization and optimization of a histone h2a-based vector for targeted gene transfer to cancer cells.” 2015. Web. 16 Jan 2021.

Vancouver:

Karjoo Diarkhan, Zahra 1. Customization and optimization of a histone h2a-based vector for targeted gene transfer to cancer cells. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/46367/.

Council of Science Editors:

Karjoo Diarkhan, Zahra 1. Customization and optimization of a histone h2a-based vector for targeted gene transfer to cancer cells. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/46367/

Rutgers University

25. Rane, Chetan K., 1989-. PAK4 as a drug target in breast cancer therapy.

Degree: PhD, Pharmacology, Cellular and Molecular, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/54913/

►

PAK4, belonging to Group II PAKs, is an important signaling protein with key roles in regulating cell growth, cell survival and cell morphology. PAK4 protein… (more)

▼

PAK4, belonging to Group II PAKs, is an important signaling protein with key roles in regulating cell growth, cell survival and cell morphology. PAK4 protein levels are higher in several subtypes of breast cancer cells and PAK4 gene is amplified in basal like breast cancer. PAK4 overexpression in a mouse mammary epithelial cell line (iMMEC) results in oncogenic transformation of these cells, while siRNA mediated PAK4 down regulation in a human triple negative breast cancer cell line, MDA-MB-231, resulted in significant inhibition of its tumorigenic potential. These results point to a central role for PAK4 in mammary tumorigenesis. PAK4 expression pattern makes it an attractive drug target, however, it is important to note that PAK4 has both kinase-dependent and – independent functions in regulating tumor formation. Hence, blocking its kinase activity alone is insufficient in blocking its tumorigenic potential. Our lab collaborated with Karyopharm Therapeutics to investigate a novel PAK4 inhibitor, KPT-9274. I observed that treatment with KPT-9274 and KPT-8752 (isoform of KPT-9274) inhibited the cell growth, cell survival and cell motility of breast cancer cell lines, with this effect most significantly observed in triple negative breast cancer cell lines. I observed that treatment with KPT inhibitors inhibited PAK4 protein levels along with PAK4 associated downstream signaling pathways in triple negative breast cancer cell lines. Most importantly, I observed that KPT- 9274 significantly inhibited tumor growth in mouse xenograft models of 3 human triple negative breast cancer cell lines. KPT-9274 was capable of reducing steady state PAK4 protein levels in vivo, without significantly affecting PAK1 protein levels, indicating that KPT-9274 exhibits in vivo PAK4 specificity. This study shows that PAK4 can serve as a novel drug target in triple negative breast cancer therapy and KPT-9274 can have clinical benefits for the triple negative breast cancer population. Next, I analyzed RNA-seq data of samples collected from non-transformed WT iMMECs and iMMECs overexpressing PAK4, that form tumors in mice. Sequencing analysis identified several genes previously unknown to be regulated by PAK4. Using q-PCR, I was able to validate the RNAseq data, further suggesting that RNA-seq is a promising and reproducible tool to study PAK4 induced transcriptional changes. This study reveals the PAK4 transcriptome profile in mammary tumor forming cells, and can provide translational utility in other types of cancers as well. Delineating the varied effectors of PAK4 signaling cascade will help uncover novel biomarkers for cancer, with some serving as potential therapeutic targets.

Advisors/Committee Members: Kong, Tony (chair), Liu, Fang (co-chair), Minden, Audrey (internal member), Cai, Li (outside member), School of Graduate Studies.

Subjects/Keywords: Breast – Cancer – Treatment; Protein kinases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rane, Chetan K., 1. (2017). PAK4 as a drug target in breast cancer therapy. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/54913/

Chicago Manual of Style (16^th Edition):

Rane, Chetan K., 1989-. “PAK4 as a drug target in breast cancer therapy.” 2017. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/54913/.

MLA Handbook (7^th Edition):

Rane, Chetan K., 1989-. “PAK4 as a drug target in breast cancer therapy.” 2017. Web. 16 Jan 2021.

Vancouver:

Rane, Chetan K. 1. PAK4 as a drug target in breast cancer therapy. [Internet] [Doctoral dissertation]. Rutgers University; 2017. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/54913/.

Council of Science Editors:

Rane, Chetan K. 1. PAK4 as a drug target in breast cancer therapy. [Doctoral Dissertation]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/54913/

Rutgers University

26. Savla, Ronak, 1987-. Tumor responsive targeted multifunctional nanosystems for cancer imaging, chemo- and siRNA therapy.

Degree: PhD, Pharmaceutical Science, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/46430/

►

Cancer is one of the most insidious diseases. Compromising of over 100 different types and sharing the unifying factors of uncontrolled growth and metastasis, unmet… (more)

▼

Cancer is one of the most insidious diseases. Compromising of over 100 different types and sharing the unifying factors of uncontrolled growth and metastasis, unmet clinical needs in terms of cancer diagnosis and treatment continue to exist. It is widely accepted that most forms of cancer are treatable or even curable if detected before widespread metastasis occurs. Nearly a quarter of deaths in the United States is the result of cancer and it only trails heart disease in terms of annual mortality. Surgery, chemotherapy, and radiation therapy are the primary treatment modalities for cancer. Research in these procedures has resulted in substantial benefits for cancer patients, but there is still room for an improvement. However, a time has been reached at which it appears that the benefits from these modalities have been reached the maximum. Therefore, it is vital to develop new strategies for the diagnosis and treatment of cancer. The field of nanotechnology is concerned with structures in the nanometer size range and holds the potential to drastically impact and improve the lives of patients suffering from cancer. Not only can nanotechnology improve current methods of diagnosis and treatment, it has a possibility of introducing newer and better modalities. The overall purpose of this work is to develop novel nanotechnology-based methodologies for the diagnosis and treatment of various forms of cancers. The first aim of the project is the development of a multifunctional targeted nanosystem for the delivery of siRNA to overcome drug resistance. The second aspect is the synthesis of a quantum dot-based delivery system that releases drug in response to pH changes. The third aim is the development of a targeted, tumor environment responsive magnetic resonance nanoparticle contrast agent coupled with a nanoparticle-based treatment.

Advisors/Committee Members: Minko, Tamara (chair), You, Guofeng (internal member), Kagan, Leonid (internal member), He, Huixin (outside member).

Subjects/Keywords: Nanoparticles; Cancer – Treatment; Tumors

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Savla, Ronak, 1. (2015). Tumor responsive targeted multifunctional nanosystems for cancer imaging, chemo- and siRNA therapy. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/46430/

Chicago Manual of Style (16^th Edition):

Savla, Ronak, 1987-. “Tumor responsive targeted multifunctional nanosystems for cancer imaging, chemo- and siRNA therapy.” 2015. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/46430/.

MLA Handbook (7^th Edition):

Savla, Ronak, 1987-. “Tumor responsive targeted multifunctional nanosystems for cancer imaging, chemo- and siRNA therapy.” 2015. Web. 16 Jan 2021.

Vancouver:

Savla, Ronak 1. Tumor responsive targeted multifunctional nanosystems for cancer imaging, chemo- and siRNA therapy. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/46430/.

Council of Science Editors:

Savla, Ronak 1. Tumor responsive targeted multifunctional nanosystems for cancer imaging, chemo- and siRNA therapy. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/46430/

Rutgers University

27. Stras, Sally. Environmentally responsive liposomes for treatment of metastatic triple negative breast cancer.

Degree: PhD, Chemical and Biochemical Engineering, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/57727/

►

In 2015, it was estimated that approximately 1.7 million women were diagnosed with breast cancer in the United States alone. Breast cancer is the most… (more)

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In 2015, it was estimated that approximately 1.7 million women were diagnosed with breast cancer in the United States alone. Breast cancer is the most common cancer among women. One in eight women in their lifetime will have to endure the tribulations of discovering that they have breast cancer and all that comes in hopes of beating the disease. Triple-negative breast cancer (TNBC) is a subgroup of breast cancer associated with a poor prognosis and a higher chance of cancer metastasis outside the breast. TNBC is defined as being negative in gene expression for estrogen receptor (ER), progesterone receptor (PR) and lacking gene expression of HER2/neu. Current methods for targeting TNBC tumors remain in investigative stages due to the difficulty in discovering an appropriate and direct method of targeting. To enable selective and effective treatment of TNBC solid tumors, we study a drug delivery carrier of cisplatin (CDDP) - a clinically accepted major line of therapy for TNBC - that is designed to ultimately result in (a) deep penetration and homogeneous distribution of the drug within tumors and (b) enhanced ii uptake by the cancer cells that constitute these tumors. Towards these aims, we engineered a carrier that is a tunable (pH-sensitive) liposome encapsulating cisplatin. These liposomes are designed to form lipid-phase separated domains at acidic pH. Domain formation is tuned to trigger content release, and the change is pH is used to increase the adsorptive/adhesive property of these liposomes. Improved tumor penetration of delivered cisplatin is expected to be achieved by triggered release of cisplatin directly within the tumor interstitial region from extravasated liposomes. Further increase in intracellularly delivered cisplatin (due to more favorable retention of liposomes by solid tumors in vivo) is expected to be achieved by liposomes that are functionalized with an adhesive switch on their surface with the aim to slow their clearance from the tumor.

Advisors/Committee Members: Sofou, Stavroula (chair), School of Graduate Studies.

Subjects/Keywords: Breast – Cancer – Treatment; Liposomes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stras, S. (2018). Environmentally responsive liposomes for treatment of metastatic triple negative breast cancer. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/57727/

Chicago Manual of Style (16^th Edition):

Stras, Sally. “Environmentally responsive liposomes for treatment of metastatic triple negative breast cancer.” 2018. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/57727/.

MLA Handbook (7^th Edition):

Stras, Sally. “Environmentally responsive liposomes for treatment of metastatic triple negative breast cancer.” 2018. Web. 16 Jan 2021.

Vancouver:

Stras S. Environmentally responsive liposomes for treatment of metastatic triple negative breast cancer. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57727/.

Council of Science Editors:

Stras S. Environmentally responsive liposomes for treatment of metastatic triple negative breast cancer. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57727/

Rutgers University

28. Chandna, Pooja, 1978-. Multicomponent targeted proapoptotic anticancer drug delivery system.

Degree: PhD, Pharmaceutical Science, 2011, Rutgers University

URL: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061166

►

Cancer is one of the leading causes of death in United States. The current approaches for the treatment of solid tumor available are the surgery… (more)

Subjects/Keywords: Drug delivery systems; Cancer – Treatment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chandna, Pooja, 1. (2011). Multicomponent targeted proapoptotic anticancer drug delivery system. (Doctoral Dissertation). Rutgers University. Retrieved from http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061166

Chicago Manual of Style (16^th Edition):

Chandna, Pooja, 1978-. “Multicomponent targeted proapoptotic anticancer drug delivery system.” 2011. Doctoral Dissertation, Rutgers University. Accessed January 16, 2021. http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061166.

MLA Handbook (7^th Edition):

Chandna, Pooja, 1978-. “Multicomponent targeted proapoptotic anticancer drug delivery system.” 2011. Web. 16 Jan 2021.

Vancouver:

Chandna, Pooja 1. Multicomponent targeted proapoptotic anticancer drug delivery system. [Internet] [Doctoral dissertation]. Rutgers University; 2011. [cited 2021 Jan 16]. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061166.

Council of Science Editors:

Chandna, Pooja 1. Multicomponent targeted proapoptotic anticancer drug delivery system. [Doctoral Dissertation]. Rutgers University; 2011. Available from: http://hdl.rutgers.edu/1782.1/rucore10001600001.ETD.000061166

Rutgers University

29. Ahuja, Karan Shashi, 1995-. Assesment of patient response to targeted cancer therapy using multi-frequency impedance cytometry and supervised machine learning.

Degree: MS, Electrical and Computer Engineering, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/57462/

► We present a novel method to rapidly assess patient response to targeted cancer therapy, where anti-neoplastic agents are conjugated to antibodies targeting surface markers on… (more)

Subjects/Keywords: Microfluidics; Cancer – Treatment; Machine learning

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ahuja, Karan Shashi, 1. (2018). Assesment of patient response to targeted cancer therapy using multi-frequency impedance cytometry and supervised machine learning. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/57462/

Chicago Manual of Style (16^th Edition):

Ahuja, Karan Shashi, 1995-. “Assesment of patient response to targeted cancer therapy using multi-frequency impedance cytometry and supervised machine learning.” 2018. Masters Thesis, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/57462/.

MLA Handbook (7^th Edition):

Ahuja, Karan Shashi, 1995-. “Assesment of patient response to targeted cancer therapy using multi-frequency impedance cytometry and supervised machine learning.” 2018. Web. 16 Jan 2021.

Vancouver:

Ahuja, Karan Shashi 1. Assesment of patient response to targeted cancer therapy using multi-frequency impedance cytometry and supervised machine learning. [Internet] [Masters thesis]. Rutgers University; 2018. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57462/.

Council of Science Editors:

Ahuja, Karan Shashi 1. Assesment of patient response to targeted cancer therapy using multi-frequency impedance cytometry and supervised machine learning. [Masters Thesis]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57462/

Rutgers University

30. Al-Mahmood, Sumayah Abed Ahmed, 1982-. Nanotechnology approach for targeted treatment of triple negative breast cancer.

Degree: MS, Pharmaceutical Science, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/49904/

► Breast cancer is one of the most devastating diseases worldwide. Triple negative breast cancer cells (TNBCs) are defined by the lack of progesterone receptor (PR),… (more)

▼ Breast cancer is one of the most devastating diseases worldwide. Triple negative breast cancer cells (TNBCs) are defined by the lack of progesterone receptor (PR), estrogen receptor (ER), and epidermal growth factor receptor 2 (EGFR2) expressions. TNBCs account for 10%- 20% of all breast carcinomas. The study is aimed at examining the efficacy of gefitinib and EGFR-targeted siRNA delivered by liposomes for treating triple negative breast cancer (TNBC). The experiments were carried out using two types of human breast cancer (BC) cell lines MCF-7 (estrogen positive BC, EPBC) and MDA-MB 231(TNBC). EGFR-targeted siRNA and gefitinib were delivered by cationic and neutral liposomes, respectively. A fluorescence microscope was used to study cellular internalization of labeled liposomes and siRNA. The expression of the targeted mRNA was performed using quantitative reverse transcription PCR. Finally, cytotoxicity of liposomal siRNA and gefitinib alone or in combination was measured using the modified MTT assay with appropriate controls. It was found that liposomes effectively delivered siRNA into both types of BC cells and suppressed the expression of targeted EGFR mRNA. However, formulations without gefitinib did not influence significantly on the viability of BC cells. Free drug demonstrated the ability to kill both types of cancer cells. Nevertheless, toxicity of gefitinib in TNBC was 2.5 times lower when compared with EPBC cells. The delivery of the drug by liposomes significantly enhanced its toxicity (1.2 and 2.5 times in EPBC and TNBC, respectively). The combination of liposomal siRNA and liposomal gefitinib demonstrated exceptionally high cytotoxicity when compared with the free drug (143 and 62 times higher in EPBC and TNBC, respectively). Suppression of EGFR mRNA effectively suppressed resistance of TNBC cells to gefitinib. The data obtained support the proposed approach and showed high potential of liposomal EGFR siRNA in combination with liposomal gefitinib in treatment of TNBC. Advisors/Committee Members: Minko, Tamara (chair), Michniak-Kohn, Bozena (internal member), You, Guofeng (internal member).

Subjects/Keywords: Nanotechnology; Breast – Cancer – Treatment

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Al-Mahmood, Sumayah Abed Ahmed, 1. (2016). Nanotechnology approach for targeted treatment of triple negative breast cancer. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/49904/

Chicago Manual of Style (16^th Edition):

Al-Mahmood, Sumayah Abed Ahmed, 1982-. “Nanotechnology approach for targeted treatment of triple negative breast cancer.” 2016. Masters Thesis, Rutgers University. Accessed January 16, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/49904/.

MLA Handbook (7^th Edition):

Al-Mahmood, Sumayah Abed Ahmed, 1982-. “Nanotechnology approach for targeted treatment of triple negative breast cancer.” 2016. Web. 16 Jan 2021.

Vancouver:

Al-Mahmood, Sumayah Abed Ahmed 1. Nanotechnology approach for targeted treatment of triple negative breast cancer. [Internet] [Masters thesis]. Rutgers University; 2016. [cited 2021 Jan 16]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49904/.

Council of Science Editors:

Al-Mahmood, Sumayah Abed Ahmed 1. Nanotechnology approach for targeted treatment of triple negative breast cancer. [Masters Thesis]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/49904/

Open Access Theses and Dissertations