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You searched for subject:(Cancer Chemoprevetion). Showing records 1 – 2 of 2 total matches.

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1. Silva, Diego Augusto Lopes da, 1987-. Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus).

Degree: 2017, Universidade Estadual de Campinas

Abstract: The plant Tribulus terrestris (TT) is used to treat numerous health problems in many traditional medicines. One of the most frequent indication of use is for the treatment of sexual dysfunction, because of its supposed ability to interfere with androgenic metabolism. Because of this, TT became popular among individuals of various ages, having been used as a natural and legal alternative for anabolics. However, the use of substances that interfere with hormonal balance can have negative consequences for prostate histophysiology, since the prostate is an organ that is the target of androgen action and sensitive to hormonal changes. On the other hand, data from the literature indicate a possible chemoprotective action of some of the major components of TT, the saponins, which would be able to attenuate deleterious effects of age and exposure to toxic agents. Thus, this work has proposed to present an extensive review of the literature on the role of this herbal medicine in aspects of reproductive biology (Chapter I) and to evaluate the effects of the use of TT extract on testosterone levels and its consequences on the histophysiology of the prostate in intact Mongolian gerbil, or those exposed to the carcinogen N-methyl-N-nitrosourea (MNU). To evaluate the effects of short-term exposure (Chapter II), 24 males were divided into four groups: experimental control, control of carcinogenic induction (50 mg/kg of MNU in a single dose on the 180º day), control of TT effects (11 mg/kg, in daily doses from 180º to 270º day) and treatment after induction (11 mg/kg of TT, in daily doses from 180º to 270º day, after a single dose of 50 mg/kg of MNU on the 180º day). To evaluate the effects of long-term exposure (Chapter III), 24 males were divided into four groups: experimental control, carcinogenic induction control (50 mg/kg MNU, in a single dose on the 180º day), control of prolonged use of TT (11 mg/kg in daily doses from 90º to 270º day) and prolonged treatment associated with induction (11 mg/kg of TT, in daily doses from 90º to 270º day, with a single dose of 50 mg/kg of MNU on the 180º day). TT was not able to raise serum testosterone levels and did not cause biometric changes in androgen-sensitive organs, which indicates low anabolic potential at the dose and periods administered. In addition, the herbal medicine may have contributed to the chemoprotection of the prostate as it has delayed the onset of malignant lesions in the gland. There was a specific action of TT in reducing the activity of the canonical androgenic pathway (decrease of androgen receptors and proliferation of epithelial cells), reproducing, in vivo, the protection against the tumor activity already observed in vitro. However, in spite of repressing the onset of malignant lesions, TT was not able to prevent the onset of premalignant lesions, especially when the use started in young individuals. Thus, the effects of TT on the prostate need to be better understood and phytotherapeutic use still requires caution Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Taboga, Sebastião Roberto (advisor), Santos, Fernanda Cristina Alcântara dos (coadvisor), Universidade Estadual de Campinas. Instituto de Biologia (institution), Programa de Pós-Graduação em Biologia Celular e Estrutural (nameofprogram), Borges, Luciano de Figueiredo (committee member), Augusto, Taize Machado (committee member), Oliveira, Silvia Borges Pimentel de (committee member), Delella, Flavia Karina (committee member).

Subjects/Keywords: Tribulus terrestris; Prostata; Cancer - Quimioprevenção; Gerbilos; Testosterona; Tribulus terrestris; Prostate; Cancer - Chemoprevetion; Gerbils; Testosterone

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Silva, Diego Augusto Lopes da, 1. (2017). Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus). (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/332303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Silva, Diego Augusto Lopes da, 1987-. “Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus).” 2017. Thesis, Universidade Estadual de Campinas. Accessed December 05, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/332303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Silva, Diego Augusto Lopes da, 1987-. “Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus).” 2017. Web. 05 Dec 2020.

Vancouver:

Silva, Diego Augusto Lopes da 1. Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus). [Internet] [Thesis]. Universidade Estadual de Campinas; 2017. [cited 2020 Dec 05]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Silva, Diego Augusto Lopes da 1. Efeitos do fitoterápico Tribulus terrestris sobre a próstata do gerbilo da Mongólia (Meriones unguiculatus) : Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus): Effects of the herbal remedy Tribulus terrestris on the prostate of the Mongolian gerbil (Meriones unguiculatus). [Thesis]. Universidade Estadual de Campinas; 2017. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/332303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Northeastern University

2. Feitosa, Barbara Viana Machado. Chemo prevention treatment for women with high risk to develop breast cancer.

Degree: MS, Department of Mechanical and Industrial Engineering, 2016, Northeastern University

Recent studies and clinical trials, such Breast Cancer Prevention Trial (BCPT), have shown a great reduction in the risk of developing invasive breast cancer among high-risk women by taking specific drugs, like tamoxifen and raloxifene. Despite the significant reduction in breast cancer risk, which is approximately the same risk reduction as seen with bilateral prophylactic mastectomies, many women are not currently opting to take the anti-estrogen medication for breast cancer prevention.; The most common reasons why patients are not opting to take the preventive therapy are that patients are more likely to accept preventive services if recommended by their physician, but that doesn't happen since they are not sufficiently trained in risk/benefit analysis. Patients also can experience fear and an overestimation of the side effects. A common perception also afflicting patients is that preventive therapy will not substantially reduce risk of developing breast cancer. Finally, the risk of breast cancer is not associated with a clinical sign or symptom. Therefore, the goal of this project is to simulate and compare the intake of both medicines and then compare with placebo, when no medicine is taken. The result will be in terms of Quality Adjusted Life Years (QALY), a generic measure of disease burden, including both the quality and the quantity of life lived.; In the future, studies like this can support the development of an online decision making tool for patients' own evaluation on whether to take or not to take the medicine. It is expected that more knowledge and studies will eventually increase the awareness among female patients prescribing chemoprevention therapy.

Subjects/Keywords: breast cancer; chemoprevetion; simulation; Cancer; Chemoprevention; Breast; Cancer; Prevention; Breast; Cancer; Risk factors; Physician and patient; Medicine, Preventive; Tamoxifen; Raloxifene

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Feitosa, B. V. M. (2016). Chemo prevention treatment for women with high risk to develop breast cancer. (Masters Thesis). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20237286

Chicago Manual of Style (16th Edition):

Feitosa, Barbara Viana Machado. “Chemo prevention treatment for women with high risk to develop breast cancer.” 2016. Masters Thesis, Northeastern University. Accessed December 05, 2020. http://hdl.handle.net/2047/D20237286.

MLA Handbook (7th Edition):

Feitosa, Barbara Viana Machado. “Chemo prevention treatment for women with high risk to develop breast cancer.” 2016. Web. 05 Dec 2020.

Vancouver:

Feitosa BVM. Chemo prevention treatment for women with high risk to develop breast cancer. [Internet] [Masters thesis]. Northeastern University; 2016. [cited 2020 Dec 05]. Available from: http://hdl.handle.net/2047/D20237286.

Council of Science Editors:

Feitosa BVM. Chemo prevention treatment for women with high risk to develop breast cancer. [Masters Thesis]. Northeastern University; 2016. Available from: http://hdl.handle.net/2047/D20237286

.