subject:(Calvaria)

1. Paré, Arnaud. Role de l'apport d'une structure tridimensionnelle tripériodique dans la régénération osseuse en zone ischémique : application aux défauts osseux mandibulaires interrupteurs : Role of the dioxygen input for the bone regeneration in ischemic area : study in segmental mandible defect.

Degree: Docteur es, Biologie, médecine et santé, 2019, Nantes

URL: http://www.theses.fr/2019NANT1006

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Dans les défauts osseux mandibulaires interrupteurs étendus, les transplants micro-anastomosés restent le gold standard mais au prix de procédés chirurgicaux lourds et d’une morbidité́ accrue… (more)

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Dans les défauts osseux mandibulaires interrupteurs étendus, les transplants micro-anastomosés restent le gold standard mais au prix de procédés chirurgicaux lourds et d’une morbidité́ accrue au niveau du site de prélèvement. L’ingénierie tissulaire osseuse a pour objectif d’éviter le prélèvement autologue par l’utilisation de biomatériaux qui servent de support à la repousse osseuse. Les études précédentes ont montré́ la nécessité́ d’y associer des adjuvants cellulaires et moléculaires pour permettre une formation osseuse. Cependant l’efficacité́ reste limitée à des volumes osseux restreints. Cette problématique est principalement due à la difficulté́ de pouvoir contrôler les macro et microarchitectures du scaffold qui doivent favoriser sa colonisation par les cellules endothéliales et ostéogènes. L'autre défi est de pouvoir assurer un apport pérenne en dioxygène et nutriments. Ainsi, l'objectif de ce travail a été de concevoir une céramique phosphocalcique sur mesure pour une reconstruction segmentaire mandibulaire incluant des caractéristiques architecturales propices à la néoformation osseuse. Une étude préliminaire de faisabilité a été réalisée chez le rat (défauts calvariaux) en associant de la moelle osseuse totale (MOT) à l’implant. Une seconde étude préclinique chez le gros animal (brebis) a ensuite été réalisée en implantant une biocéramique phosphocalcique sur mesure incluant une boucle vasculaire et de la MOT afin de reconstruire un défaut mandibulaire interrupteur.

In the craniofacial area, the causes of segmental mandible loss can be from several origins such as oncological excision, trauma or congenital deformities. In this context, autologous free tissue transfer remains the gold standard allowing satisfying functional and aesthetical outcomes but involving heavy surgical procedure, prolonged operative-time and substantial morbidity of the donor site. The goal of bone tissue engineering is to avoid the autologous harvest by the use of biomaterials that serve as support for bone healing. Previous studies have shown the need to combine cellular and molecular adjuvants (e.g., bone marrow, growth factors, osteoprogenitor cells) to scaffolds to obtain de novo bone formation. However, the efficiency for mandible reconstruction remains limited. To contribute to solving this reconstructive roadblock, the control of the scaffold architecture is the cornerstone fostering the colonization by the endothelial and osteogenic cells. The challenge is also to ensure sufficient vascular supply to keep endogenous and exogenous cells alive and functional. Thus, the objective of this work was to design a custom-made macroporous bioceramic tailored to a segmental mandible defect with architectural features, adjuvants and intrinsic vascularization favoring the bone formation. a preliminary study was performed in the rat model to assess the ability of a tailored phosphate calcium bioceramic to promote the bone healing. Then, a preclinical study in larger animal model (sheep) was performed by implanting a biphasic calcium…

Advisors/Committee Members: Corre, Pierre (thesis director), Gauthier, Olivier (thesis director).

Subjects/Keywords: Défauts de calvaria

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Paré, A. (2019). Role de l'apport d'une structure tridimensionnelle tripériodique dans la régénération osseuse en zone ischémique : application aux défauts osseux mandibulaires interrupteurs : Role of the dioxygen input for the bone regeneration in ischemic area : study in segmental mandible defect. (Doctoral Dissertation). Nantes. Retrieved from http://www.theses.fr/2019NANT1006

Chicago Manual of Style (16^th Edition):

Paré, Arnaud. “Role de l'apport d'une structure tridimensionnelle tripériodique dans la régénération osseuse en zone ischémique : application aux défauts osseux mandibulaires interrupteurs : Role of the dioxygen input for the bone regeneration in ischemic area : study in segmental mandible defect.” 2019. Doctoral Dissertation, Nantes. Accessed January 28, 2021. http://www.theses.fr/2019NANT1006.

MLA Handbook (7^th Edition):

Paré, Arnaud. “Role de l'apport d'une structure tridimensionnelle tripériodique dans la régénération osseuse en zone ischémique : application aux défauts osseux mandibulaires interrupteurs : Role of the dioxygen input for the bone regeneration in ischemic area : study in segmental mandible defect.” 2019. Web. 28 Jan 2021.

Vancouver:

Paré A. Role de l'apport d'une structure tridimensionnelle tripériodique dans la régénération osseuse en zone ischémique : application aux défauts osseux mandibulaires interrupteurs : Role of the dioxygen input for the bone regeneration in ischemic area : study in segmental mandible defect. [Internet] [Doctoral dissertation]. Nantes; 2019. [cited 2021 Jan 28]. Available from: http://www.theses.fr/2019NANT1006.

Council of Science Editors:

Paré A. Role de l'apport d'une structure tridimensionnelle tripériodique dans la régénération osseuse en zone ischémique : application aux défauts osseux mandibulaires interrupteurs : Role of the dioxygen input for the bone regeneration in ischemic area : study in segmental mandible defect. [Doctoral Dissertation]. Nantes; 2019. Available from: http://www.theses.fr/2019NANT1006

Texas A&M University

2. Rodgers, Anika Sarah. Dickkopf-1 in Craniofacial Bone and Tooth Development.

Degree: PhD, Biomedical Sciences, 2014, Texas A&M University

URL: http://hdl.handle.net/1969.1/153595

► Dickkopf-1 (Dkk1) is a potent inhibitor of the Wnt/β-catenin signaling pathway in both tooth and bone development. Deletion of the Dkk1 gene in mice leads… (more)

▼ Dickkopf-1 (Dkk1) is a potent inhibitor of the Wnt/β-catenin signaling pathway in both tooth and bone development. Deletion of the Dkk1 gene in mice leads to embryonic lethality, whereas transgenic mice over-expressing Dkk1 in mature osteoblasts result in osteopenia. Targeted expression of Dkk1 in dental epithelial cells leads to the formation of dysfunctional enamel knots and subsequent tooth defects during embryonic development. However, the direct role of Dkk1 in post-natal dentinogenesis and calvarial osteogenesis is largely unknown. To address this issue, we analyzed 2.3-kb Col1a1 Dkk1-transgenic (Tg) mice, which over-express Dkk1 in immature and mature odontoblasts and osteoblasts. The Dkk1 transgene was highly expressed in pulp and odontoblast cells during post-natal developmental stages. A disruption in tooth development was obvious with the 1st mandibular molar displaying short roots, an enlarged pulp/root canal region, and a decreased dentin formation rate. Also within the mandible, the 2nd molar is small and malformed and the 3rd molar is absent. The molars possess an increased number of immature odontoblasts, very few mature odontoblasts, and a sharp reduction in dentinal tubule number accompanying a dramatic change in expression of certain odontoblast markers, such as Osterix and Nestin. The calvarial bone presents with a significantly pronounced bone defect within Dkk1-Tg mice. The defect exhibits a markedly reduced calvarial bone density and multiple regions lacking any bone mineralization, which is indicative of an osteogenic deficiency. A greater than 60% reduction of parietal bone volume as well as an incomplete articulation of the parietal bones abutting the sagittal suture is evident. Irregularly shaped and abnormally small osteocytes are housed within the underdeveloped bone presenting more as osteoblastic-like cells in structure/function. Most obviously, the calvaria rather unusually presents with a considerable increase in osteoclast cell number, maturation, and activity present on the endo-cranial surface. An increase in immature osteoblast markers, as well as a decrease in mature osteoblast markers combined with an increase in active osteoclast markers was evidence of a disrupted bone homeostasis. From our studies we propose that within molar development and calvarial bone development, Dkk1 over-expression disrupts post-natal dentin formation and instigates an uncoupling of the osteoblastic/osteoclastic bone remodeling activities in favor of bone resorption with an increase in osteoclast-mediated destruction. Dkk1 is able to exert its effects directly via the inhibition of Wnt signaling or indirectly via its regulation of Osterix expression. Advisors/Committee Members: Feng, Jian Q (advisor), Opperman, Lynne (committee member), Dechow, Paul (committee member), Ruest, Bruno (committee member).

Subjects/Keywords: Dickkopf1; Calvaria; Dentinogenesis; Osteogenesis; Osteoclastogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rodgers, A. S. (2014). Dickkopf-1 in Craniofacial Bone and Tooth Development. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/153595

Chicago Manual of Style (16^th Edition):

Rodgers, Anika Sarah. “Dickkopf-1 in Craniofacial Bone and Tooth Development.” 2014. Doctoral Dissertation, Texas A&M University. Accessed January 28, 2021. http://hdl.handle.net/1969.1/153595.

MLA Handbook (7^th Edition):

Rodgers, Anika Sarah. “Dickkopf-1 in Craniofacial Bone and Tooth Development.” 2014. Web. 28 Jan 2021.

Vancouver:

Rodgers AS. Dickkopf-1 in Craniofacial Bone and Tooth Development. [Internet] [Doctoral dissertation]. Texas A&M University; 2014. [cited 2021 Jan 28]. Available from: http://hdl.handle.net/1969.1/153595.

Council of Science Editors:

Rodgers AS. Dickkopf-1 in Craniofacial Bone and Tooth Development. [Doctoral Dissertation]. Texas A&M University; 2014. Available from: http://hdl.handle.net/1969.1/153595

3. Burim, Rafael Augusto. Avaliação da reparação de defeitos ósseos críticos na calvária de ratos Wistar sob ação sistêmica de Icariin: estudo radiográfico, histomorfológico e histomorfométrico.

Degree: Mestrado, Cirurgia e Traumatologia Buco-Maxilo-Faciais, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/23/23149/tde-02092013-180120/ ;

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A reconstrução de defeitos ósseos críticos é alvo de inúmeras pesquisas em cirurgia bucomaxilofacial. Tais pesquisas visam, de maneira geral, a optimização da neoformação óssea… (more)

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A reconstrução de defeitos ósseos críticos é alvo de inúmeras pesquisas em cirurgia bucomaxilofacial. Tais pesquisas visam, de maneira geral, a optimização da neoformação óssea e a eliminação dos procedimentos de remoção de osso autógeno para reconstrução. Os modelos animais têm sido a metodologia mais utilizada para avaliar a eficácia de novas substâncias e biomateriais na reparação óssea. O objetivo desta pesquisa foi avaliar a influência de um flavonóide, o icariin, na reparação óssea de defeitos críticos confeccionados na calvária de ratos Wistar. Um defeito ósseo crítico circular foi confeccionado em 40 calvarias de ratos por meio de uma broca trefina de 8 mm de diâmetro sob irrigação salina constante. Ao final dos procedimentos cirúrgicos, os animais foram divididos, aleatoriamente, em grupo teste (n=20), que recebeu o icariin, na dose de 125 mg/kg de peso e grupo controle (n=20), que recebeu soro fisiológico. Ambas as substâncias foram administradas por meio de gavagem até o dia da eutanásia. Ao final de cada período observacional de 7, 14, 21 e 42 dias, 5 animais de cada grupo foram eutanasiados e as amostras da calvária foram removidas e mantidas em formol 10% por 48 horas. As calvárias foram radiografadas e, após descalcificação, foram submetidas à avaliação histológica com coloração hematoxilina-eosina sob microscópio de luz. Os defeitos foram analisados considerando a diminuição da área do defeito na imagem radiográfica, as características de reparo ósseo e a osteogênese na região da ferida. Os resultados da análise radiográfica mostraram que a área do defeito ósseo no grupo teste foi significativamente menor que no grupo controle em todos os períodos observacionais. A avaliação histológica mostrou um aumento na neoformação óssea do grupo teste (p=0,02). A histomorfometria demonstrou osteogênese significante no grupo teste com 7 dias (p=0,021), 14 dias (p=0,014), 21 dias (p=0,021) e 42 dias (p=0,009). Foi possível concluir que o icariin sistêmico induziu uma maior neoformação óssea em defeitos críticos.

Bone critical defect reconstruction is an important target in current oral surgery research. Contemporary research has been searching for osteogenesis optimization to minimize the necessity of using autogenous bone grafts procedures. Animal models have been the widespread methodology to evaluate the effect of different new substances and biomaterials in bone healing. The aim of this study was to assess the influence of systemic daily flavonoid, icariin, in the repair of calvaria critical size defects induced in Wistar rats. A round critical size defect was performed centrally in 40 rats calvaria using an 8mm trephine under sterile saline solution irrigation. After surgery, half the animals, randomly, received by gavage daily doses of 125mg/Kg-icariin (Test Group) till the euthanasia. The other half (Control Group) received the same volume of saline solution. Five animals of each group were euthanized after 7, 14, 21 and 42 days postoperatively. The rats calvaria were removed, fixed in 10% formalin for…

Advisors/Committee Members: Deboni, Maria Cristina Zindel.

Subjects/Keywords: Bone regeneration; Calvaria; Calvaria; Cicatrização; Epimedium; Epimedium; Ratos Wistar; Regeneração óssea; Wistar rat; Wound healing

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Burim, R. A. (2013). Avaliação da reparação de defeitos ósseos críticos na calvária de ratos Wistar sob ação sistêmica de Icariin: estudo radiográfico, histomorfológico e histomorfométrico. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/23/23149/tde-02092013-180120/ ;

Chicago Manual of Style (16^th Edition):

Burim, Rafael Augusto. “Avaliação da reparação de defeitos ósseos críticos na calvária de ratos Wistar sob ação sistêmica de Icariin: estudo radiográfico, histomorfológico e histomorfométrico.” 2013. Masters Thesis, University of São Paulo. Accessed January 28, 2021. http://www.teses.usp.br/teses/disponiveis/23/23149/tde-02092013-180120/ ;.

MLA Handbook (7^th Edition):

Burim, Rafael Augusto. “Avaliação da reparação de defeitos ósseos críticos na calvária de ratos Wistar sob ação sistêmica de Icariin: estudo radiográfico, histomorfológico e histomorfométrico.” 2013. Web. 28 Jan 2021.

Vancouver:

Burim RA. Avaliação da reparação de defeitos ósseos críticos na calvária de ratos Wistar sob ação sistêmica de Icariin: estudo radiográfico, histomorfológico e histomorfométrico. [Internet] [Masters thesis]. University of São Paulo; 2013. [cited 2021 Jan 28]. Available from: http://www.teses.usp.br/teses/disponiveis/23/23149/tde-02092013-180120/ ;.

Council of Science Editors:

Burim RA. Avaliação da reparação de defeitos ósseos críticos na calvária de ratos Wistar sob ação sistêmica de Icariin: estudo radiográfico, histomorfológico e histomorfométrico. [Masters Thesis]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/23/23149/tde-02092013-180120/ ;

4. 徳田, 知子. Comparison of the bone forming ability of different sized-alpha tricalcium phosphate granules using a critical size defect model of the mouse calvaria : マウス頭蓋冠臨界骨欠損モデルを用いた粒径の異なるα型第三リン酸カルシウム顆粒の骨形成能の比較.

Degree: 博士（歯学）, 2016, Osaka Dental University / 大阪歯科大学

URL: http://id.nii.ac.jp/1392/00000105/

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Alpha-tricalcium phosphate (α-TCP) has been investigated extensively as an artificial bone graft; however, the relationship between size of α-TCP particles and its bone-formation capability is… (more)

Subjects/Keywords: alpha tricalcium phosphate; bone formation; particle; calvaria; hydrolysis

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APA (6^th Edition):

徳田, �. (2016). Comparison of the bone forming ability of different sized-alpha tricalcium phosphate granules using a critical size defect model of the mouse calvaria : マウス頭蓋冠臨界骨欠損モデルを用いた粒径の異なるα型第三リン酸カルシウム顆粒の骨形成能の比較. (Thesis). Osaka Dental University / 大阪歯科大学. Retrieved from http://id.nii.ac.jp/1392/00000105/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

徳田, 知子. “Comparison of the bone forming ability of different sized-alpha tricalcium phosphate granules using a critical size defect model of the mouse calvaria : マウス頭蓋冠臨界骨欠損モデルを用いた粒径の異なるα型第三リン酸カルシウム顆粒の骨形成能の比較.” 2016. Thesis, Osaka Dental University / 大阪歯科大学. Accessed January 28, 2021. http://id.nii.ac.jp/1392/00000105/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

徳田, 知子. “Comparison of the bone forming ability of different sized-alpha tricalcium phosphate granules using a critical size defect model of the mouse calvaria : マウス頭蓋冠臨界骨欠損モデルを用いた粒径の異なるα型第三リン酸カルシウム顆粒の骨形成能の比較.” 2016. Web. 28 Jan 2021.

Vancouver:

徳田 �. Comparison of the bone forming ability of different sized-alpha tricalcium phosphate granules using a critical size defect model of the mouse calvaria : マウス頭蓋冠臨界骨欠損モデルを用いた粒径の異なるα型第三リン酸カルシウム顆粒の骨形成能の比較. [Internet] [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. [cited 2021 Jan 28]. Available from: http://id.nii.ac.jp/1392/00000105/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

徳田 �. Comparison of the bone forming ability of different sized-alpha tricalcium phosphate granules using a critical size defect model of the mouse calvaria : マウス頭蓋冠臨界骨欠損モデルを用いた粒径の異なるα型第三リン酸カルシウム顆粒の骨形成能の比較. [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. Available from: http://id.nii.ac.jp/1392/00000105/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

5. Alsendi, Maryam Abdulaziz. The effect of anti-inflammatory drugs on bone remodeling using ex-vivo cultures of mouse calvarial bone.

Degree: MSin Design, Periodontology, 2020, Boston University

URL: http://hdl.handle.net/2144/41342

► OBJECTIVE: To determine the effect of anti-inflammatory drugs (4- methoxybenzophenone) and (kavain) on bone formation and bone resorption models using a three-dimensional (3D) live calvarial… (more)

Subjects/Keywords: Dentistry; Anti-inflammatory drugs; Bone; Calcium; Calvaria; Formation; Resorption

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alsendi, M. A. (2020). The effect of anti-inflammatory drugs on bone remodeling using ex-vivo cultures of mouse calvarial bone. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/41342

Chicago Manual of Style (16^th Edition):

Alsendi, Maryam Abdulaziz. “The effect of anti-inflammatory drugs on bone remodeling using ex-vivo cultures of mouse calvarial bone.” 2020. Masters Thesis, Boston University. Accessed January 28, 2021. http://hdl.handle.net/2144/41342.

MLA Handbook (7^th Edition):

Alsendi, Maryam Abdulaziz. “The effect of anti-inflammatory drugs on bone remodeling using ex-vivo cultures of mouse calvarial bone.” 2020. Web. 28 Jan 2021.

Vancouver:

Alsendi MA. The effect of anti-inflammatory drugs on bone remodeling using ex-vivo cultures of mouse calvarial bone. [Internet] [Masters thesis]. Boston University; 2020. [cited 2021 Jan 28]. Available from: http://hdl.handle.net/2144/41342.

Council of Science Editors:

Alsendi MA. The effect of anti-inflammatory drugs on bone remodeling using ex-vivo cultures of mouse calvarial bone. [Masters Thesis]. Boston University; 2020. Available from: http://hdl.handle.net/2144/41342

6. Quraishi, Syrah Imtiaz. The Effect Of Focused Extracorporeal Shock Wave (ESW) On Calvaria Bone Ex Vivo.

Degree: 2013, Marquette University

URL: https://epublications.marquette.edu/theses_open/199

► Introduction: Extracorporeal shock wave (ESW) is low frequency high-pressure wave, regularly used to destroy calcifications e.g. kidney stone. Recent evidence shows that ESW produces micro-cracks… (more)

▼ Introduction: Extracorporeal shock wave (ESW) is low frequency high-pressure wave, regularly used to destroy calcifications e.g. kidney stone. Recent evidence shows that ESW produces micro-cracks in the bones of horse legs. As micro-cracks in bone can lead to an increased rate of bone turnover (remodeling), we hypothesize that proper application of ESW will increase bone turnover rate through generating micro-cracks in bone. Materials and Methods: To test our hypothesis, we used a mouse calvaria bone organ culture model and explored the effects of ESW on bone tissues ex vivo. The calvaria bone pieces were collected from 3 days old C57BL/6 neonatal mice and cultured in 10% FBS supplemented DMEM. After dissection, each quadrant (1/4) of calvaria was randomly assigned into one control and three experimental groups which were subjected to a single dose of 2000 shocks of 3 energy levels of ESW i.e. low (0.1mJ/mm², 6 Hz), medium (0.25mJ/mm², 4 Hz), and high (0.5mJ/mm², 3 Hz,) doses, respectively. After ESW stimulation, the bone tissues were further cultured for 1 week and fixed in 10% formalin. The same experiment was repeated three times (n=3). The bone samples were (1) examined by using a customized radiographic analysis program to measure the bone microdensity, and (2) demineralized and processed to undergo H&E staining to observe the cellular changes histologically. Results: Radiographically the mid dose group exhibited a higher microdensity but not statistically significant (P > 0.05) compared to the other two ESW and the control groups. Histologically, some empty osteocytic lacunae exhibited in all the three dose ESW groups, with nearly all osteocytes disappeared in the high dose group. Hypertrophy of osteoblasts was mainly found in the low dose group. No microcracks were observed on all the H&E staining tissue slides. Histological differences cannot be calculated statistically mainly due to the high heterogeneity of the samples. Conclusion: Although not statistically significant, the mid dose ESW group seems to gain bone microdensity. Due to the lack of statistical differences, definite conclusions cannot be drawn, leaving further endeavors be put on this topic. Advisors/Committee Members: Liu, Dawei, Bradly, Gerry, Bosio, Jose A..

Subjects/Keywords: Accelerate; Calvaria bone; ESW; Focused; Orthodontics; Tooth movement

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APA (6^th Edition):

Quraishi, S. I. (2013). The Effect Of Focused Extracorporeal Shock Wave (ESW) On Calvaria Bone Ex Vivo. (Thesis). Marquette University. Retrieved from https://epublications.marquette.edu/theses_open/199

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Quraishi, Syrah Imtiaz. “The Effect Of Focused Extracorporeal Shock Wave (ESW) On Calvaria Bone Ex Vivo.” 2013. Thesis, Marquette University. Accessed January 28, 2021. https://epublications.marquette.edu/theses_open/199.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Quraishi, Syrah Imtiaz. “The Effect Of Focused Extracorporeal Shock Wave (ESW) On Calvaria Bone Ex Vivo.” 2013. Web. 28 Jan 2021.

Vancouver:

Quraishi SI. The Effect Of Focused Extracorporeal Shock Wave (ESW) On Calvaria Bone Ex Vivo. [Internet] [Thesis]. Marquette University; 2013. [cited 2021 Jan 28]. Available from: https://epublications.marquette.edu/theses_open/199.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Quraishi SI. The Effect Of Focused Extracorporeal Shock Wave (ESW) On Calvaria Bone Ex Vivo. [Thesis]. Marquette University; 2013. Available from: https://epublications.marquette.edu/theses_open/199

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Helsinki

7. Maidell-Hjort, Laura. Gli2-transkriptiofaktorin merkitys kallon ja kasvojen luiden kehityksessä : esitutkimus hiirimallin avulla.

Degree: Medicinska fakulteten, 2016, University of Helsinki

URL: http://hdl.handle.net/10138/163421

► Osa kallon ja kasvojen luista kehittyy elimistön kannalta ainutlaatuisella tavalla intramembranoottisesti suoraan mesenkyymistä. Siten osteoblastien erilaistumista säätelevien geenien mutaatiot tulevat usein selkeästi esiin kallon ja… (more)

Subjects/Keywords: Gli2; osteoblast; craniofacial development; morphogenesis; calvaria; face; Orthodontics; Hampaiston oikomishoito; Ortodonti

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Maidell-Hjort, L. (2016). Gli2-transkriptiofaktorin merkitys kallon ja kasvojen luiden kehityksessä : esitutkimus hiirimallin avulla. (Masters Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/10138/163421

Chicago Manual of Style (16^th Edition):

Maidell-Hjort, Laura. “Gli2-transkriptiofaktorin merkitys kallon ja kasvojen luiden kehityksessä : esitutkimus hiirimallin avulla.” 2016. Masters Thesis, University of Helsinki. Accessed January 28, 2021. http://hdl.handle.net/10138/163421.

MLA Handbook (7^th Edition):

Maidell-Hjort, Laura. “Gli2-transkriptiofaktorin merkitys kallon ja kasvojen luiden kehityksessä : esitutkimus hiirimallin avulla.” 2016. Web. 28 Jan 2021.

Vancouver:

Maidell-Hjort L. Gli2-transkriptiofaktorin merkitys kallon ja kasvojen luiden kehityksessä : esitutkimus hiirimallin avulla. [Internet] [Masters thesis]. University of Helsinki; 2016. [cited 2021 Jan 28]. Available from: http://hdl.handle.net/10138/163421.

Council of Science Editors:

Maidell-Hjort L. Gli2-transkriptiofaktorin merkitys kallon ja kasvojen luiden kehityksessä : esitutkimus hiirimallin avulla. [Masters Thesis]. University of Helsinki; 2016. Available from: http://hdl.handle.net/10138/163421

8. Kotake, Bruna Gabriela dos Santos. Avaliação da reparação óssea em defeitos críticos após a aplicação da proteína rhBMP-2 pura e/ou combinada em animais normais e sob efeito do alcoolismo crônico.

Degree: Mestrado, Biologia Oral, 2012, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/58/58137/tde-04122012-164616/ ;

►

O alcoolismo é considerado um redutor da formação óssea, podendo levar a distúrbios osteometabólicos, já a rhBMP-2 é uma proteína morfogenética conhecida por desempenhar um… (more)

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O alcoolismo é considerado um redutor da formação óssea, podendo levar a distúrbios osteometabólicos, já a rhBMP-2 é uma proteína morfogenética conhecida por desempenhar um papel importante nos processos de reparação e indução da formação óssea. O objetivo deste estudo foi investigar a ação do alcoolismo e a resposta do reparo em defeitos ósseos (DO) na calvária de ratos, após a aplicação da rhBMP-2, pura e combinada a uma matriz de colágeno. Foram utilizados 80 ratos divididos em 8 grupos, cada um deles com um período de espera até o sacrifício de 4 e 6 semanas, após a criação cirúrgica do defeito ósseo na calvária de 5 mm. Os grupos foram divididos em G1) água äd libitum+̈ DO, G2) álcool äd libitum+̈ DO, G3) água + DO + 5μg rhBMP-2 pura, G4) álcool + DO + 5μg rhBMP-2 pura, G5) água + DO + carreador esponja de colágeno, G6) álcool + DO + carreador esponja de colágeno, G7) água e + DO + 5μg rhBMP- 2/esponja de colágeno, G8) álcool + DO + 5μg rhBMP-2/esponja de colágeno. Os dados radiográficos e os dados para a análise de fibras colágena tipo I e III foram submetidos à análise estatística Kruskal-Wallis e Dunn\'s Multiple, os dados histológicos ao teste de análise de variância (ANOVA) e Tukey. O resultado encontrado para a análise radiográfica no tempo de 6 semanas demonstrou que os grupos tratados com rhBMP-2 independente da utilização do carreador e do etanol apresentaram maior neoformação óssea (p<0,05), para o tempo de 4 semanas não foi encontrada diferença estatística. Para a análise imunoistoquímica, a ostecalcina (OC) e sialoproteína óssea (BPS) foram predominantes nos grupos tratados com rhBMP-2. Para a análise histológica, a quantificação de fibras colágenas tipo I apresentou diferença estatística entre os grupos (p<0,05), com aumento destas fibras principalmente nos grupos tradados com rhBMP-2 associado a esponja de colágeno; e na análise quantitativa por estereologia, o volume de tecido ósseo neoformado foi maior para os grupos tratados com rhBMP-2 pura ou associada ao carreador, porém para os grupos tratados com etanol, houve maior neoformação óssea para o grupo tratado com rhBMP-2 associado ao carreador nos períodos de 4 e 6 semanas (p<0,001). Concluiu-se neste modelo experimental que, o carreador foi efetivo na bioliberação da rhBMP-2, mesmo na presença do etanol.

Alcoholism is considered a reducer for new bone formation, may leading to osteometabolic disturbance, considering that the rhBMP-2 is a morphogenetic protein known to play an important role in the bone healing processes. The aim of this study was to investigate the action of alcoholism and its effect on the repair of bone defects (DO) performed in rat calvaria after the rhBMP-2 application, pure or combined with a collagen matrix. We used 80 rats divided into eight groups, each one with a waiting period for sacrifice of 4 and 6 weeks after the bone defect (5mm) delineation in the rat skull. The groups were divided into: G1) water äd libitum+̈ DO, G2) alcohol äd libitum+̈ DO, G3) water + DO + 5μg pure rhBMP-2,…

Advisors/Committee Members: Issa, João Paulo Mardegan.

Subjects/Keywords: alcoholism; alcoolismo; bone formation and calvaria; collagen sponge; esponja de colágeno; neoformação óssea e calvária; rhBMP-2; rhBMP-2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kotake, B. G. d. S. (2012). Avaliação da reparação óssea em defeitos críticos após a aplicação da proteína rhBMP-2 pura e/ou combinada em animais normais e sob efeito do alcoolismo crônico. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/58/58137/tde-04122012-164616/ ;

Chicago Manual of Style (16^th Edition):

Kotake, Bruna Gabriela dos Santos. “Avaliação da reparação óssea em defeitos críticos após a aplicação da proteína rhBMP-2 pura e/ou combinada em animais normais e sob efeito do alcoolismo crônico.” 2012. Masters Thesis, University of São Paulo. Accessed January 28, 2021. http://www.teses.usp.br/teses/disponiveis/58/58137/tde-04122012-164616/ ;.

MLA Handbook (7^th Edition):

Kotake, Bruna Gabriela dos Santos. “Avaliação da reparação óssea em defeitos críticos após a aplicação da proteína rhBMP-2 pura e/ou combinada em animais normais e sob efeito do alcoolismo crônico.” 2012. Web. 28 Jan 2021.

Vancouver:

Kotake BGdS. Avaliação da reparação óssea em defeitos críticos após a aplicação da proteína rhBMP-2 pura e/ou combinada em animais normais e sob efeito do alcoolismo crônico. [Internet] [Masters thesis]. University of São Paulo; 2012. [cited 2021 Jan 28]. Available from: http://www.teses.usp.br/teses/disponiveis/58/58137/tde-04122012-164616/ ;.

Council of Science Editors:

Kotake BGdS. Avaliação da reparação óssea em defeitos críticos após a aplicação da proteína rhBMP-2 pura e/ou combinada em animais normais e sob efeito do alcoolismo crônico. [Masters Thesis]. University of São Paulo; 2012. Available from: http://www.teses.usp.br/teses/disponiveis/58/58137/tde-04122012-164616/ ;

University of Debrecen

9. Szakács, Dóra Fanni. Aerogél és hidrogél alapú csontpótló anyagok in vivo vizsgálata patkány calvaria modellen .

Degree: DE – Fogorvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/240865

► A fogorvosi és szájsebészeti gyakorlatban a csontpótlás a szöveti helyreállítás egyik legszélesebb körben tanulmányozott területe. A csontpótlók alkalmazása mára a mindennapi gyakorlat részévé vált olyan… (more)

▼ A fogorvosi és szájsebészeti gyakorlatban a csontpótlás a szöveti helyreállítás egyik legszélesebb körben tanulmányozott területe. A csontpótlók alkalmazása mára a mindennapi gyakorlat részévé vált olyan csontdefektusok esetén, amikor az endogén regeneráló mechanizmusok nem elegendőek a teljes gyógyulás eléréshez. Bár a saját, autológ csont a legideálisabb a volumen helyreállítására, ez korlátozott mennyiségben áll rendelkezésre, ezért egy új, a csontpótlás szigorú követelményeinek megfelelő alternatíva létrehozása került a vizsgálatok középpontjába. Kísérletünk során a korong, illetve granulátum formában előkészített aerogél és hidrogél alapú csontpótlók hatására kiváltott szöveti reakciót vizsgáltuk patkány calvaria modellben. Célunk az volt, hogy a legígéretesebb eredményeket prezentáló anyagokat kiválasztva előkészítsünk egy nagyobb számú állatot felhasználó vizsgálatot. Kilenc darab muszkuloszkeletálisan érett Wistar patkány calvariáján ejtett kritikus méretű csontdefektust a következő anyagokkal töltöttünk fel: natív aerogél korong, natív aerogél granulátum, β-trikalcium-foszfát-aerogél korong, β-trikalcium-foszfát-aerogél granulátum, hidroxiapatit-aerogél korong, hidroxiapatit-aerogél granulátum, natív hidrogél korong és Straumann® BoneCeramic™ csontpótló, illetve egy kisállat a kontroll csoportot képviselte. Az állatok terminálása a műtétet követő 6-7. héten történt, melynek során a koponyatetőt is eltávolítottuk és paraformaldehidben fixáltuk. A beágyazást követően vékonycsiszolatot készítettünk, így dekalcinálás nélkül követhettük a csontosodási folyamatot hematoxilin-eozin festés mellett. A szövettani kiértékelés során a kontroll minta kivételével minden defektusban találtunk kezdődő csontosodásra utaló jelet. A kötőszövetes átalakuláson kívül az új szövet kalcifikálódását figyeltük meg hidroxiapatit-aerogél korong, hidrogél, BoneCeramic™, β-trikalcium-foszfát-aerogél korong és granulátum esetén. Az utóbbi négy anyaggal és a natív aerogél granulátummal tovább folytattuk a vizsgálatot, a kísérletek jelenleg is zajlanak. Advisors/Committee Members: Boda, Róbert (advisor), Debreceni Egyetem::Fogorvostudományi Kar::Arc- Állcsont- és Szájsebészeti Tanszék (advisor).

Subjects/Keywords: állatkísérleti modell; csontpótló anyag; calvaria; patkány; aerogél; hidrogél

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Szakács, D. F. (n.d.). Aerogél és hidrogél alapú csontpótló anyagok in vivo vizsgálata patkány calvaria modellen . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/240865

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Szakács, Dóra Fanni. “Aerogél és hidrogél alapú csontpótló anyagok in vivo vizsgálata patkány calvaria modellen .” Thesis, University of Debrecen. Accessed January 28, 2021. http://hdl.handle.net/2437/240865.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Szakács, Dóra Fanni. “Aerogél és hidrogél alapú csontpótló anyagok in vivo vizsgálata patkány calvaria modellen .” Web. 28 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Szakács DF. Aerogél és hidrogél alapú csontpótló anyagok in vivo vizsgálata patkány calvaria modellen . [Internet] [Thesis]. University of Debrecen; [cited 2021 Jan 28]. Available from: http://hdl.handle.net/2437/240865.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Szakács DF. Aerogél és hidrogél alapú csontpótló anyagok in vivo vizsgálata patkány calvaria modellen . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/240865

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

10. Amaral, Mauricio Bordini do. Capacidade de regeneração óssea de biomateriais em defeito crítico de calvária: análise histológica e microtomografia computadorizada.

Degree: PhD, Bioengenharia, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/82/82131/tde-23052013-091250/ ;

►

O elevado número de cirurgias de enxertia óssea impulsiona o desenvolvimento de novos biomateriais de preenchimento. Materiais a base de hidroxiapatita sintética e tendão bovino… (more)

▼

O elevado número de cirurgias de enxertia óssea impulsiona o desenvolvimento de novos biomateriais de preenchimento. Materiais a base de hidroxiapatita sintética e tendão bovino mineralizado foram preparados para servirem de arcabouço para regeneração óssea. Este estudo teve como objetivo avaliar a osteocondutibilidade desses materiais, comparando-os ao Bio-Oss/Geistlich. Foram criados defeitos de tamanho crítico (circular / 8 mm) na calvária de ratos Wistar, preenchidos com os biomateriais e, após 30 dias, ocorreu o sacrifício, análise não invasiva por microtomografia computadorizada (micro-CT/ microtomógrafo SkyScan 100kV - 100\'mü\'A) com reconstituição de imagem em três dimensões (3D) e análise histológica convencional para avaliar a neoformação óssea e comparar os métodos. Os resultados da micro-CT mostraram que o Bio-Oss apresentou maior volume, densidade e porcentagem de tecido ósseo que os demais grupos. Nas imagens reconstituídas em 3D notou-se no grupo Bio-Oss as menores taxas de reabsorção, permanecendo em maior quantidade no interior do defeito aos trinta dias. No grupo da hidroxiapatita sintética notou-se uma intensa reabsorção do material e uma leve neoformação óssea nas margens do defeito, deixando-o com um contorno irregular. O grupo do tendão bovino mineralizado apresentou discretíssima neoformação óssea e o material foi totalmente reabsorvido. Já na avaliação da presença do material, de vasos sanguíneos e das células osteoblásticas no interior do defeito obtidos através da análise histológica, os grupos Bio-Oss e hidroxiapatita sintética obtiveram resultados semelhantes e maiores que o tendão bovino mineralizado. Constatou-se através da análise histológica que a hidroxiapatita sintética mostrou-se presente no interior do defeito exibindo propriedades osteocondutoras semelhantes a marca comercial Bio-Oss. Já o tendão bovino mineralizado não teve boa osteocondução, sendo contra-indicado na manutenção do espaço ósseo. Na comparação dos dois métodos, constatou-se que a micro-CT apresenta baixa especificidade, ou seja, não foi capaz de distinguir o tecido ósseo do Bio-Oss e alta sensibilidade, pois quantifica de uma forma muito precisa os valores com alta resolução. Já a análise histológica consegue distinguir com precisão os materiais e o tecido adjacente, porém não consegue quantificá-los de maneira fácil e precisa. Portanto, conclui-se que a hidroxiapatita sintética tem grande potencial de ser utilizada no preenchimento de defeitos ósseos, diferentemente do tendão bovino mineralizado. Quanto aos métodos de avaliação, eles são complementares e novos aprimoramentos devem ser feitos na técnica de micro-CT para melhorar sua capacidade de distinguir diferentes materiais.

Biodegradable bone grafts have been widely employed on bone regeneration. The purpose of this study was to evaluate the osteoconductive potential of hydroxyapatite, mineralized bovine tendon and Bio-Oss/Geistlich in a rat critical-size calvaria defect model through non-destructive three-dimensional (3D) micro-tomographic (\'mü\'CT)…

Advisors/Committee Members: Plepis, Ana Maria de Guzzi.

Subjects/Keywords: Biomateriais; Biomaterial; Bone regeneration; Calvaria critical size defect; Defeito crítico calvária rato; Enxerto ósseo; Hidroxiapatita; Hydroxyapatite; Micro-computed tomography ('mü'-CT); Microtomografia computadorizada

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Amaral, M. B. d. (2013). Capacidade de regeneração óssea de biomateriais em defeito crítico de calvária: análise histológica e microtomografia computadorizada. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/82/82131/tde-23052013-091250/ ;

Chicago Manual of Style (16^th Edition):

Amaral, Mauricio Bordini do. “Capacidade de regeneração óssea de biomateriais em defeito crítico de calvária: análise histológica e microtomografia computadorizada.” 2013. Doctoral Dissertation, University of São Paulo. Accessed January 28, 2021. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-23052013-091250/ ;.

MLA Handbook (7^th Edition):

Amaral, Mauricio Bordini do. “Capacidade de regeneração óssea de biomateriais em defeito crítico de calvária: análise histológica e microtomografia computadorizada.” 2013. Web. 28 Jan 2021.

Vancouver:

Amaral MBd. Capacidade de regeneração óssea de biomateriais em defeito crítico de calvária: análise histológica e microtomografia computadorizada. [Internet] [Doctoral dissertation]. University of São Paulo; 2013. [cited 2021 Jan 28]. Available from: http://www.teses.usp.br/teses/disponiveis/82/82131/tde-23052013-091250/ ;.

Council of Science Editors:

Amaral MBd. Capacidade de regeneração óssea de biomateriais em defeito crítico de calvária: análise histológica e microtomografia computadorizada. [Doctoral Dissertation]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/82/82131/tde-23052013-091250/ ;

11. 篠,弘道. ラット頭頂骨における骨外側方向への骨増生に対するメラトニンの影響 : Effect of melatonin on guided bone augmentation beyond the skeletal envelope in rat calvaria.

Degree: 博士（歯学）, 2016, Nihon University / 日本大学

URL: http://repository.nihon-u.ac.jp/xmlui/handle/11263/674 ; http://dx.doi.org/10.15006/32665A5076

Subjects/Keywords: メラトニン; melatonin; 骨増生; bone augmentation; ラット頭蓋冠; rat calvaria

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

篠,弘道. (2016). ラット頭頂骨における骨外側方向への骨増生に対するメラトニンの影響 : Effect of melatonin on guided bone augmentation beyond the skeletal envelope in rat calvaria. (Thesis). Nihon University / 日本大学. Retrieved from http://repository.nihon-u.ac.jp/xmlui/handle/11263/674 ; http://dx.doi.org/10.15006/32665A5076

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

篠,弘道. “ラット頭頂骨における骨外側方向への骨増生に対するメラトニンの影響 : Effect of melatonin on guided bone augmentation beyond the skeletal envelope in rat calvaria.” 2016. Thesis, Nihon University / 日本大学. Accessed January 28, 2021. http://repository.nihon-u.ac.jp/xmlui/handle/11263/674 ; http://dx.doi.org/10.15006/32665A5076.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

篠,弘道. “ラット頭頂骨における骨外側方向への骨増生に対するメラトニンの影響 : Effect of melatonin on guided bone augmentation beyond the skeletal envelope in rat calvaria.” 2016. Web. 28 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

篠,弘道. ラット頭頂骨における骨外側方向への骨増生に対するメラトニンの影響 : Effect of melatonin on guided bone augmentation beyond the skeletal envelope in rat calvaria. [Internet] [Thesis]. Nihon University / 日本大学; 2016. [cited 2021 Jan 28]. Available from: http://repository.nihon-u.ac.jp/xmlui/handle/11263/674 ; http://dx.doi.org/10.15006/32665A5076.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

篠,弘道. ラット頭頂骨における骨外側方向への骨増生に対するメラトニンの影響 : Effect of melatonin on guided bone augmentation beyond the skeletal envelope in rat calvaria. [Thesis]. Nihon University / 日本大学; 2016. Available from: http://repository.nihon-u.ac.jp/xmlui/handle/11263/674 ; http://dx.doi.org/10.15006/32665A5076

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

12. Chatzipetros, Emmanouil. Η επίδραση του βιοϋλικού υδροξυαπατίτη/χιτοζάνης στην κατευθυνόμενη οστική ανάπλαση προκλητών κρανιακών ελλειμμάτων επίμυων.

Degree: 2020, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/47404

► Τhis study aims at determining the effect of 75/25 w/w nHAp/CS scaffolds on Guided Bone Regeneration (GBR) in rat calvarial critical-size defects (CSD) and the… (more)

▼ Τhis study aims at determining the effect of 75/25 w/w nHAp/CS scaffolds on Guided Bone Regeneration (GBR) in rat calvarial critical-size defects (CSD) and the ability of Cone Beam Computed Tomography (CBCT) to visualize CSD created at rat calvaria and filled with 75/25 w/w nHAp/CS scaffolds. Materials and Methods: Thirty six Sprague Dawley adult rats, approximately 3 months old, 18 males and 18 females, weighing more than 250g, were used. These were housed in the Laboratory of Experimental Surgery of the Medical School of the University of Athens, where stable conditions of heating, ventilation and relative humidity were maintained. Also, daily animal health monitoring, as well as daily care and nutrition were performed by a specialized veterinarian and by a specialized animal dietician respectively. All animal handling and surgical procedures were conducted in accordance with the guidelines of animal care and the use of laboratory experimental animals. This experimental study was approved by the Directorate of Agricultural and Veterinary Policy with protocol number 1181/2-03-2017 and registration code EL 25 BIO 05, Athens, Greece. Also, this study protocol was in line with EU Directive 2010/63/EU, based on the concept of replacement, reduction and refinement of animal studies (the 3R principle). The sample size was minimized in accordance with the aims of “Animal Research: Reporting of In Vivo Experimental guidelines (ARRIVE)”. Also, the size of the sample was estimated with power analysis (Power 1-β err prob=0.6949) using one-way ANOVA Fixed effects (IBM SPSS 25.0, IBM Corp., Armonk, N.Y., USA). The introduction of gender as a variable was intended to limit the use of only male rats, in agreement with the National Institute of Health (NIH, NOT-OD-15-102) notice. Thus, three study groups were created for each time period up to euthanasia (2, 4 and 8 weeks, respectively). Each group comprised of twelve rats (6 males and 6 females). The number of animals used was comparable to that of previous GBR studies. Nanoparticles of hydroxyapatite (nHAp) were synthesized according to our previous work, in the presence of hyperbranched polyethylene imine (Lupasol G100, BASF, Greece), to regulate the size and morphology of hydroxyapatite crystals. Composite porous scaffolds were developed by preparing a 3% w/w chitosan (Aldrich, high molecular weight, deacetylation degree ≥75%) solution in aqueous acetic acid (1.5% w/w), and adding nHAp to a final HAp:CS weight ratio of 75:25. The resulting thick slurry was thoroughly mixed and molded in glass tubes (5mm inner diameter) that were subsequently frozen at -25 °C and lyophilized. After lyophilization the resulting HAp:CS cylindrical porous scaffolds (5mm diameter) were cut into disks of 1mm thickness, ethanol sterilized and extensively washed with sterile phosphate buffer saline inside a laminar flow cabinet. By determining the volume of liquid infused in their pores, porosity and total pore volume were found to be 85±1% and 5.0±0.5mL/g respectively.Preoperatively, a 10-day…

Subjects/Keywords: Οστική ανάπλαση; Χιτοζάνη; Υδροξυαπατίτης; Κρανίο επίμυων; Bone regeneration; Chitosan; Hydroxyapatites; Rat calvaria; Guided Bone Regeneration (GBR); Cone Beam Computed Tomography (CBCT) analysis; Histomorphometric analysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chatzipetros, E. (2020). Η επίδραση του βιοϋλικού υδροξυαπατίτη/χιτοζάνης στην κατευθυνόμενη οστική ανάπλαση προκλητών κρανιακών ελλειμμάτων επίμυων. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/47404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chatzipetros, Emmanouil. “Η επίδραση του βιοϋλικού υδροξυαπατίτη/χιτοζάνης στην κατευθυνόμενη οστική ανάπλαση προκλητών κρανιακών ελλειμμάτων επίμυων.” 2020. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 28, 2021. http://hdl.handle.net/10442/hedi/47404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chatzipetros, Emmanouil. “Η επίδραση του βιοϋλικού υδροξυαπατίτη/χιτοζάνης στην κατευθυνόμενη οστική ανάπλαση προκλητών κρανιακών ελλειμμάτων επίμυων.” 2020. Web. 28 Jan 2021.

Vancouver:

Chatzipetros E. Η επίδραση του βιοϋλικού υδροξυαπατίτη/χιτοζάνης στην κατευθυνόμενη οστική ανάπλαση προκλητών κρανιακών ελλειμμάτων επίμυων. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2020. [cited 2021 Jan 28]. Available from: http://hdl.handle.net/10442/hedi/47404.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chatzipetros E. Η επίδραση του βιοϋλικού υδροξυαπατίτη/χιτοζάνης στην κατευθυνόμενη οστική ανάπλαση προκλητών κρανιακών ελλειμμάτων επίμυων. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2020. Available from: http://hdl.handle.net/10442/hedi/47404

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Brock, Ryane Schmidt [UNESP]. Retalho ósseo neo-fabricado de gálea e periósteo preenchido com células-tronco mesenquimais, plasma rico em plaquetas, pó de osso e ácido hialurônico. estudo em coelho.

Degree: 2017, Universidade Estadual Paulista

URL: http://hdl.handle.net/11449/148751

►

As deformidades craniofaciais decorrentes de traumas, ressecções de tumores ou malformações congênitas são freqüentes na prática médica e o tratamento destas necessitam de cirurgia reparadora,… (more)

▼

As deformidades craniofaciais decorrentes de traumas, ressecções de tumores ou malformações congênitas são freqüentes na prática médica e o tratamento destas necessitam de cirurgia reparadora, com técnicas especializadas e profissionais qualificados para corrigir os defeitos e proporcionar melhor qualidade de vida, aprimorar a fala, respiração, mastigação e deglutição. Há diversas técnicas descritas para corrigir os defeitos ósseos, cada uma com vantagens e desvantages, escolhidas de acordo com o tipo de deformidade. Este estudo avaliou a formação óssea em um retalho tubular vascularizado, gáleo-periostal, enriquecido com o uso de pó de osso, plasma rico em plaquetas, células-tronco mesenquimais e ácido hialurônico, em coelhos, que tenha capacidade de substituir o enxerto ósseo nas reconstruções, principalmente nos defeitos faciais. No estudo, utilizou-se 98 coelhos divididos em doze grupos, submetidos à cirurgia para confecção do retalho em calota craniana. Foram realizados retalhos tubulares com o periósteo voltado para dentro e preenchidos com pó de osso, plasma rico em plaquetas (PRP), células-tronco mesenquimais (CTM) e ácido hialurônico. O Grupo 1 não foi manipulado. No Grupo 2 foi realizado o retalho tubular e mantido vazio. O Grupo 3 teve o retalho preenchido com pó de osso, no Grupo 4 o retalho foi mantido vazio. O Grupo 5 teve o retalho preenchido com PRP. No Grupo 6 o retalho foi preenchido com PRP e pó de osso. O Grupo 7 foi preenchido com CTM. O Grupo 8 teve o retalho preenchido com CTM e pó de osso. O Grupo 9 teve o retalho preenchido com CTM e PRP. No Grupo 10, o retalho tubular foi preenchido com PRP, CTM e pó de osso. O Grupo 11 foi mantido vazio e o Grupo 12 foi preenchido com ácido hialurônico. Os resultados foram avaliados através de métodos de imagem e avaliação histológica. Os resultados demonstraram que, no modelo experimental utilizado, os grupos com apenas periósteo, isto é, retalho tubular vazio, apresentaram formação óssea pequena e irregular. No grupo com PRP também houve a formação óssea irregular e imatura. Quando o PRP foi associado ao pó de osso houve uma formação mais regular e organizada. O grupo com célula-tronco mesenquimal também apresentou formação óssea, com características teciduais organizadas, próprias do tecido ósseo maduro. Quando associada ao pó de osso e ao PRP, as características histológicas apresentaram-se com tecido organizado, regular, maduro com células bem formadas e organizadas. O uso de materiais com fatores de crescimento celular ósseo melhoram a qualidade e organização do tecido neoformado. Quanto maior o número de fatores de enriquecimento usados, melhores foram os resultados quanto a qualidade tecidual neoformada.

Craniofacial deformities caused by traumas, tumor ressections or congenital malformation are frequent in medical practice, and their treatment with reconstructive surgeries are common, especially in plastic surgery, which aim to provide the patients with better quality of life and functional improvement of speach, breathing, chewing and…

Advisors/Committee Members: Oliveira Neto, Fausto Viterbo de [UNESP], Deffune, Elenice [UNESP], Universidade Estadual Paulista (UNESP).

Subjects/Keywords: Osso; Malformação crânio-facial; Calvária; Retalho; Reconstrução; Face; Enxerto ósseo; Enxerto de gordura; Plasma rico em plaquetas; Célula-tronco mesenquimal; Ácido hialurônico; Coelho; Embriogênese óssea; Bone; Calvaria; Craniofacial malformation; Flap; Reconstruction; Graft; Mesenchymal stem cell; Platelet rich plasma; Hyaluronic acid; Rabbit; Osseous embryogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brock, R. S. [. (2017). Retalho ósseo neo-fabricado de gálea e periósteo preenchido com células-tronco mesenquimais, plasma rico em plaquetas, pó de osso e ácido hialurônico. estudo em coelho. (Thesis). Universidade Estadual Paulista. Retrieved from http://hdl.handle.net/11449/148751

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brock, Ryane Schmidt [UNESP]. “Retalho ósseo neo-fabricado de gálea e periósteo preenchido com células-tronco mesenquimais, plasma rico em plaquetas, pó de osso e ácido hialurônico. estudo em coelho.” 2017. Thesis, Universidade Estadual Paulista. Accessed January 28, 2021. http://hdl.handle.net/11449/148751.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brock, Ryane Schmidt [UNESP]. “Retalho ósseo neo-fabricado de gálea e periósteo preenchido com células-tronco mesenquimais, plasma rico em plaquetas, pó de osso e ácido hialurônico. estudo em coelho.” 2017. Web. 28 Jan 2021.

Vancouver:

Brock RS[. Retalho ósseo neo-fabricado de gálea e periósteo preenchido com células-tronco mesenquimais, plasma rico em plaquetas, pó de osso e ácido hialurônico. estudo em coelho. [Internet] [Thesis]. Universidade Estadual Paulista; 2017. [cited 2021 Jan 28]. Available from: http://hdl.handle.net/11449/148751.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brock RS[. Retalho ósseo neo-fabricado de gálea e periósteo preenchido com células-tronco mesenquimais, plasma rico em plaquetas, pó de osso e ácido hialurônico. estudo em coelho. [Thesis]. Universidade Estadual Paulista; 2017. Available from: http://hdl.handle.net/11449/148751

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

14. Slotte, Christer 1954-. On surgical techniques to increase bone density and volume. Studies in the rat and the rabbit.

Degree: 2003, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/15936

► BACKGROUND. Various techniques of surgical intervention have been suggested to promote bone densityand volume; however, the predictability of such techniques is not always sufficiently supported… (more)

▼ BACKGROUND. Various techniques of surgical intervention have been suggested to promote bone densityand volume; however, the predictability of such techniques is not always sufficiently supported by preclinicalevaluations.AIM. The general aim of the present thesis was to evaluate some surgical techniques claimed to increasebone volume and density and thereby improve implant retention and survival. In particular, the aims were toinvestigate the effect of cortical perforations of tibial, maxillary, and calvarial bone alone or in conjunctionwith a) titanium implants, b) guided bone augmentation (GBA) barriers, or c) GBA barriers combined withgrafting materials. In addition, the histologic characteristics of untreated calvarial bone were studied withspecial emphasis on vessel topography.MATERIALS AND METHODS. In study I, the effect of cortical perforations in the tibia and the maxilla wasevaluated in the rabbit, and the healing response in the two bones was compared. In study II, the effect ofsurgical intervention in the rabbit maxilla 4 weeks prior to implant placement was evaluated and comparedwith the effect of the implant placement per se. In study III, a rat calvarial model was used to study the effectof bovine bone mineral (BBM) placement as an adjunct to a silicone GBA barrier. In study IV, the impact ofcortical perforations in the rabbit calvaria contiguous to a titanium GBA barrier was evaluated. In study V,placement of autogeneic bone or BBM combined with a titanium GBA barrier was studied in a rabbit calvarialmodel. In study VI, vessel topography and bone density were studied in untreated rabbit calvaria.RESULTS. As observed 8 weeks postoperatively, cortical perforation resulted in significant bone densityincrease in the rabbit maxilla while no significant changes were found in the tibia. Implant placementsignificantly increased bone density while surgical intervention 4 weeks prior to implant placement did notfurther increase bone density or bone-implant contact. Cortical perforations were not found to promote boneaugmentation in the rabbit GBA model. Similar amounts of bone tissue and mineralized bone were found withthe adjunctive placement of autogeneic bone or BBM in the rabbit GBA model. In both the rat and the rabbitGBA models, the adjunctive placement of BBM significantly increased augmented bone tissue volumecompared to placement of barriers only. In the rabbit model, the addition of BBM was found to promotesignificantly more mineralized bone than placement of a barrier only. In the rat model, on the contrary,placement of the silicone barrier alone promoted more mineralized bone than with the addition of BBM. Theproportions of cortical, trabecular, and marrow areas found in the right and left untreated parietal bones weresimilar, as were the number and width of natural hollow connections in the cortical plates and the distributionof vessels. A similar number of these hollow connections was found in untreated and GBA-treated parietalbone.CONCLUSIONS. The different bone response to cortical perforations…

Subjects/Keywords: autogeneic bone; bovine bone mineral; calvaria; cortical perforation; guided bone augmentation; maxilla; microangiography; morphometry; rabbit; rat; tibia; titanium implants; vessel topography

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Slotte, C. 1. (2003). On surgical techniques to increase bone density and volume. Studies in the rat and the rabbit. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/15936

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Slotte, Christer 1954-. “On surgical techniques to increase bone density and volume. Studies in the rat and the rabbit.” 2003. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed January 28, 2021. http://hdl.handle.net/2077/15936.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Slotte, Christer 1954-. “On surgical techniques to increase bone density and volume. Studies in the rat and the rabbit.” 2003. Web. 28 Jan 2021.

Vancouver:

Slotte C1. On surgical techniques to increase bone density and volume. Studies in the rat and the rabbit. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2003. [cited 2021 Jan 28]. Available from: http://hdl.handle.net/2077/15936.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Slotte C1. On surgical techniques to increase bone density and volume. Studies in the rat and the rabbit. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2003. Available from: http://hdl.handle.net/2077/15936

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. 土屋,紀子. Effects of platelet-derived growth factor on bone augmentation beyond the skeletal envelope in rat calvaria : ラット頭頂骨における骨外側方向への骨増生に対する PDGF の影響.

Degree: 博士（歯学）, 2014, Nihon University / 日本大学

URL: http://repository.nihon-u.ac.jp/xmlui/handle/11263/188 ; http://dx.doi.org/10.15006/32665A4798

Subjects/Keywords: 血小板由来増殖因子; platelet-derived growth factor; 骨増生; bone augmentation; ラット頭頂骨; rat calvaria

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

土屋,紀子. (2014). Effects of platelet-derived growth factor on bone augmentation beyond the skeletal envelope in rat calvaria : ラット頭頂骨における骨外側方向への骨増生に対する PDGF の影響. (Thesis). Nihon University / 日本大学. Retrieved from http://repository.nihon-u.ac.jp/xmlui/handle/11263/188 ; http://dx.doi.org/10.15006/32665A4798

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

土屋,紀子. “Effects of platelet-derived growth factor on bone augmentation beyond the skeletal envelope in rat calvaria : ラット頭頂骨における骨外側方向への骨増生に対する PDGF の影響.” 2014. Thesis, Nihon University / 日本大学. Accessed January 28, 2021. http://repository.nihon-u.ac.jp/xmlui/handle/11263/188 ; http://dx.doi.org/10.15006/32665A4798.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

土屋,紀子. “Effects of platelet-derived growth factor on bone augmentation beyond the skeletal envelope in rat calvaria : ラット頭頂骨における骨外側方向への骨増生に対する PDGF の影響.” 2014. Web. 28 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

土屋,紀子. Effects of platelet-derived growth factor on bone augmentation beyond the skeletal envelope in rat calvaria : ラット頭頂骨における骨外側方向への骨増生に対する PDGF の影響. [Internet] [Thesis]. Nihon University / 日本大学; 2014. [cited 2021 Jan 28]. Available from: http://repository.nihon-u.ac.jp/xmlui/handle/11263/188 ; http://dx.doi.org/10.15006/32665A4798.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

土屋,紀子. Effects of platelet-derived growth factor on bone augmentation beyond the skeletal envelope in rat calvaria : ラット頭頂骨における骨外側方向への骨増生に対する PDGF の影響. [Thesis]. Nihon University / 日本大学; 2014. Available from: http://repository.nihon-u.ac.jp/xmlui/handle/11263/188 ; http://dx.doi.org/10.15006/32665A4798

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

16. 佐藤,暢亮. ラット頭頂骨GBAモデルにおける骨髄穿通孔の大きさが骨増生および血管新生に及ぼす影響 : Influence of bone augmentation and angiogenesis with different sizes of bone marrow penetration in rat calvarial GBA model.

Degree: 博士（歯学）, 2016, Nihon University / 日本大学

URL: http://repository.nihon-u.ac.jp/xmlui/handle/11263/673 ; http://dx.doi.org/10.15006/32665A5075

Subjects/Keywords: ラット頭頂骨; rat calvaria; 骨髄穿通; bone marrow penetration; 血管新生; angiogenesis; 骨増生; bone augmentation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

佐藤,暢亮. (2016). ラット頭頂骨GBAモデルにおける骨髄穿通孔の大きさが骨増生および血管新生に及ぼす影響 : Influence of bone augmentation and angiogenesis with different sizes of bone marrow penetration in rat calvarial GBA model. (Thesis). Nihon University / 日本大学. Retrieved from http://repository.nihon-u.ac.jp/xmlui/handle/11263/673 ; http://dx.doi.org/10.15006/32665A5075

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

佐藤,暢亮. “ラット頭頂骨GBAモデルにおける骨髄穿通孔の大きさが骨増生および血管新生に及ぼす影響 : Influence of bone augmentation and angiogenesis with different sizes of bone marrow penetration in rat calvarial GBA model.” 2016. Thesis, Nihon University / 日本大学. Accessed January 28, 2021. http://repository.nihon-u.ac.jp/xmlui/handle/11263/673 ; http://dx.doi.org/10.15006/32665A5075.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

佐藤,暢亮. “ラット頭頂骨GBAモデルにおける骨髄穿通孔の大きさが骨増生および血管新生に及ぼす影響 : Influence of bone augmentation and angiogenesis with different sizes of bone marrow penetration in rat calvarial GBA model.” 2016. Web. 28 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

佐藤,暢亮. ラット頭頂骨GBAモデルにおける骨髄穿通孔の大きさが骨増生および血管新生に及ぼす影響 : Influence of bone augmentation and angiogenesis with different sizes of bone marrow penetration in rat calvarial GBA model. [Internet] [Thesis]. Nihon University / 日本大学; 2016. [cited 2021 Jan 28]. Available from: http://repository.nihon-u.ac.jp/xmlui/handle/11263/673 ; http://dx.doi.org/10.15006/32665A5075.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

佐藤,暢亮. ラット頭頂骨GBAモデルにおける骨髄穿通孔の大きさが骨増生および血管新生に及ぼす影響 : Influence of bone augmentation and angiogenesis with different sizes of bone marrow penetration in rat calvarial GBA model. [Thesis]. Nihon University / 日本大学; 2016. Available from: http://repository.nihon-u.ac.jp/xmlui/handle/11263/673 ; http://dx.doi.org/10.15006/32665A5075

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

17. 津徳,亮成. Effects of the schedule and dosage of parathyroid hormone on bone regeneration : 副甲状腺ホルモンの投与回数および投与量が骨再生に与える影響.

Degree: 博士（歯学）, 2015, Nihon University / 日本大学

URL: http://repository.nihon-u.ac.jp/xmlui/handle/11263/555 ; http://dx.doi.org/10.15006/32665A4949

Subjects/Keywords: 副甲状腺ホルモン; parathyroid hormone; 骨再生; bone regeneration; ラット頭頂骨臨界骨欠損; critical-size rat calvaria bone defects

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

津徳,亮成. (2015). Effects of the schedule and dosage of parathyroid hormone on bone regeneration : 副甲状腺ホルモンの投与回数および投与量が骨再生に与える影響. (Thesis). Nihon University / 日本大学. Retrieved from http://repository.nihon-u.ac.jp/xmlui/handle/11263/555 ; http://dx.doi.org/10.15006/32665A4949

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

津徳,亮成. “Effects of the schedule and dosage of parathyroid hormone on bone regeneration : 副甲状腺ホルモンの投与回数および投与量が骨再生に与える影響.” 2015. Thesis, Nihon University / 日本大学. Accessed January 28, 2021. http://repository.nihon-u.ac.jp/xmlui/handle/11263/555 ; http://dx.doi.org/10.15006/32665A4949.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

津徳,亮成. “Effects of the schedule and dosage of parathyroid hormone on bone regeneration : 副甲状腺ホルモンの投与回数および投与量が骨再生に与える影響.” 2015. Web. 28 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

津徳,亮成. Effects of the schedule and dosage of parathyroid hormone on bone regeneration : 副甲状腺ホルモンの投与回数および投与量が骨再生に与える影響. [Internet] [Thesis]. Nihon University / 日本大学; 2015. [cited 2021 Jan 28]. Available from: http://repository.nihon-u.ac.jp/xmlui/handle/11263/555 ; http://dx.doi.org/10.15006/32665A4949.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

津徳,亮成. Effects of the schedule and dosage of parathyroid hormone on bone regeneration : 副甲状腺ホルモンの投与回数および投与量が骨再生に与える影響. [Thesis]. Nihon University / 日本大学; 2015. Available from: http://repository.nihon-u.ac.jp/xmlui/handle/11263/555 ; http://dx.doi.org/10.15006/32665A4949

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

18. Vatsa, A. Mechanosensing and Chemical Signaling in Single Osteocytes.

Degree: 2008, NARCIS

URL: https://research.vu.nl/en/publications/313e0e1c-5d27-4ab6-9687-a65004f20808 ; urn:nbn:nl:ui:31-1871/13127 ; 313e0e1c-5d27-4ab6-9687-a65004f20808 ; 1871/13127 ; urn:isbn:9789090228518 ; urn:nbn:nl:ui:31-1871/13127 ; https://research.vu.nl/en/publications/313e0e1c-5d27-4ab6-9687-a65004f20808

Subjects/Keywords: 3D reconstruction; Cell body; Cell process; Chemical Signaling; Confocal laser scanning microscopy; FOM; MC3T3 cell; MLO-Y4 cells; Mechanical loading; Mechanosensation; Mechanosensing; Nano CT scan; Nitric Oxide; Optical tweezer; Paxilin; Paxillin staining; Single lacunae; Single osteocyte; bone; bone adaptation; bone remodeling; calvaria; direct mechanosensing; external loading; fibula; in situ; intracellular; micromanipulator; paxillin; strain; stress

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vatsa, A. (2008). Mechanosensing and Chemical Signaling in Single Osteocytes. (Doctoral Dissertation). NARCIS. Retrieved from https://research.vu.nl/en/publications/313e0e1c-5d27-4ab6-9687-a65004f20808 ; urn:nbn:nl:ui:31-1871/13127 ; 313e0e1c-5d27-4ab6-9687-a65004f20808 ; 1871/13127 ; urn:isbn:9789090228518 ; urn:nbn:nl:ui:31-1871/13127 ; https://research.vu.nl/en/publications/313e0e1c-5d27-4ab6-9687-a65004f20808

Chicago Manual of Style (16^th Edition):

Vatsa, A. “Mechanosensing and Chemical Signaling in Single Osteocytes.” 2008. Doctoral Dissertation, NARCIS. Accessed January 28, 2021. https://research.vu.nl/en/publications/313e0e1c-5d27-4ab6-9687-a65004f20808 ; urn:nbn:nl:ui:31-1871/13127 ; 313e0e1c-5d27-4ab6-9687-a65004f20808 ; 1871/13127 ; urn:isbn:9789090228518 ; urn:nbn:nl:ui:31-1871/13127 ; https://research.vu.nl/en/publications/313e0e1c-5d27-4ab6-9687-a65004f20808.

MLA Handbook (7^th Edition):

Vatsa, A. “Mechanosensing and Chemical Signaling in Single Osteocytes.” 2008. Web. 28 Jan 2021.

Vancouver:

Vatsa A. Mechanosensing and Chemical Signaling in Single Osteocytes. [Internet] [Doctoral dissertation]. NARCIS; 2008. [cited 2021 Jan 28]. Available from: https://research.vu.nl/en/publications/313e0e1c-5d27-4ab6-9687-a65004f20808 ; urn:nbn:nl:ui:31-1871/13127 ; 313e0e1c-5d27-4ab6-9687-a65004f20808 ; 1871/13127 ; urn:isbn:9789090228518 ; urn:nbn:nl:ui:31-1871/13127 ; https://research.vu.nl/en/publications/313e0e1c-5d27-4ab6-9687-a65004f20808.

Council of Science Editors:

Vatsa A. Mechanosensing and Chemical Signaling in Single Osteocytes. [Doctoral Dissertation]. NARCIS; 2008. Available from: https://research.vu.nl/en/publications/313e0e1c-5d27-4ab6-9687-a65004f20808 ; urn:nbn:nl:ui:31-1871/13127 ; 313e0e1c-5d27-4ab6-9687-a65004f20808 ; 1871/13127 ; urn:isbn:9789090228518 ; urn:nbn:nl:ui:31-1871/13127 ; https://research.vu.nl/en/publications/313e0e1c-5d27-4ab6-9687-a65004f20808

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Open Access Theses and Dissertations