subject:(Calcium)

1. Inglebert, Yanis. Règle de STDP en calcium physiologique : STDP rules in physiological calcium.

Degree: Docteur es, Neurosciences, 2018, Aix Marseille Université

URL: http://www.theses.fr/2018AIXM0642

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L’utilisation de calcium en concentration physiologique pourrait diminuer ou supprimer tout phénomène de plasticité induite par la règle de STDP avec des protocoles standards. Dans… (more)

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L’utilisation de calcium en concentration physiologique pourrait diminuer ou supprimer tout phénomène de plasticité induite par la règle de STDP avec des protocoles standards. Dans la région CA1 de l’hippocampe, pour une concentration de calcium de 1.8 mM, nous observons une absence de LTP après corrélation positive, mais une LTD pour l’ensemble des délais étudiés. Pour 1.3 mM, ni LTP ni LTD ne sont observées dans nos conditions expérimentales. En plus du calcium, l’activité est une composante importante dans l’induction de la plasticité par STDP. En particulier, l’augmentation de la fréquence de stimulation pendant l’appariement ou l’augmentation du nombre de potentiels d’action post-synaptiques nous a permis de récupérer la LTP par corrélation positive à 1.3 et 1.8 mM. De la même manière, l’augmentation du nombre de potentiels d’action post-synaptiques ou de la fréquence de stimulation nous a permis de récupérer la fenêtre de LTD à 1.3 mM. Parallèlement à la modulation d’activité, nous avons testé un troisième facteur qui apparaît important : la neuromodulation. La règle de STDP serait modulée, en particulier, par l’activation des récepteurs dopaminergiques et noradrénergiques. La perfusion d’isoprénaline, un agoniste des récepteurs noradrénergiques, nous a permis de récupérer la fenêtre de LTP à 1.8 mM, contrairement à l’application de dopamine. Mes résultats montrent que la règle de STDP est profondément modifiée en calcium physiologique, mais que l’utilisation d’activités spécifiques ou l’application de neuromodulateurs sont capables de restaurer un profil de courbe normal.

The use of calcium in physiological concentration may be able to reduce or eliminate any plasticity phenomenon induced by the STDP rule with standard protocols. In the CA1 region of the hippocampus, at a calcium concentration of 1.8 mM we observed an absence of LTP after positive correlation. Instead, LTD is observed for all the delays that were tested. At 1.3 mM, neither LTP nor LTD were observed under our experimental conditions. In addition to calcium, activity is an important component in the induction of plasticity by STDP. Notably, an increase in stimulation frequency during pairing or an increase in the number of postsynaptic action potential allowed us to rescue LTP induced by positive correlation at 1.3 and 1.8 mM. Similarly, an increase in the number of postsynaptic action potentials or the frequency of stimulation allowed us to rescue the LTD window at 1.3 mM. In parallel with activity modulation, we tested a third factor that showed a noticeable impact: neuromodulation. The STDP rule appeared to be predominantly modulated by the activation of dopaminergic and noradrenergic receptors. The perfusion of Isoprenaline, a noradrenergic receptor agonist, allowed us to rescue the LTP window whereas dopamine application at 1.8 mM did not rescue LTP. This study demonstrates that the STDP rule is profoundly changed under physiological calcium conditions; however, the use of specific activities or the application of neuromodulators…

Advisors/Committee Members: Debanne, Dominique (thesis director).

Subjects/Keywords: Calcium; Calcium

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APA (6^th Edition):

Inglebert, Y. (2018). Règle de STDP en calcium physiologique : STDP rules in physiological calcium. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2018AIXM0642

Chicago Manual of Style (16^th Edition):

Inglebert, Yanis. “Règle de STDP en calcium physiologique : STDP rules in physiological calcium.” 2018. Doctoral Dissertation, Aix Marseille Université. Accessed February 22, 2020. http://www.theses.fr/2018AIXM0642.

MLA Handbook (7^th Edition):

Inglebert, Yanis. “Règle de STDP en calcium physiologique : STDP rules in physiological calcium.” 2018. Web. 22 Feb 2020.

Vancouver:

Inglebert Y. Règle de STDP en calcium physiologique : STDP rules in physiological calcium. [Internet] [Doctoral dissertation]. Aix Marseille Université 2018. [cited 2020 Feb 22]. Available from: http://www.theses.fr/2018AIXM0642.

Council of Science Editors:

Inglebert Y. Règle de STDP en calcium physiologique : STDP rules in physiological calcium. [Doctoral Dissertation]. Aix Marseille Université 2018. Available from: http://www.theses.fr/2018AIXM0642

2. Nixon, Andrew T L. On Numerical Models of Calcium-Induced Calcium Release.

Degree: PhD, Applied Mathematics, 2015, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:419475/

► In this thesis, we examine hybrid numerical models of calcium-induced calcium release using deterministic PDEs for the diffusion of cytosolic calcium and a stochastic process… (more)

Subjects/Keywords: calcium-induced calcium release

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APA (6^th Edition):

Nixon, A. T. L. (2015). On Numerical Models of Calcium-Induced Calcium Release. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:419475/

Chicago Manual of Style (16^th Edition):

Nixon, Andrew T L. “On Numerical Models of Calcium-Induced Calcium Release.” 2015. Doctoral Dissertation, Brown University. Accessed February 22, 2020. https://repository.library.brown.edu/studio/item/bdr:419475/.

MLA Handbook (7^th Edition):

Nixon, Andrew T L. “On Numerical Models of Calcium-Induced Calcium Release.” 2015. Web. 22 Feb 2020.

Vancouver:

Nixon ATL. On Numerical Models of Calcium-Induced Calcium Release. [Internet] [Doctoral dissertation]. Brown University; 2015. [cited 2020 Feb 22]. Available from: https://repository.library.brown.edu/studio/item/bdr:419475/.

Council of Science Editors:

Nixon ATL. On Numerical Models of Calcium-Induced Calcium Release. [Doctoral Dissertation]. Brown University; 2015. Available from: https://repository.library.brown.edu/studio/item/bdr:419475/

University of Texas Southwestern Medical Center

3. Yao, Jian. Ca2+ Signaling in the Near Plasma Membrane Microdomain of Non-Excitable Cells.

Degree: 2011, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/864

► Calcium is the most versatile second messenger and plays fundamental roles in orchestrating enzyme secretion in exocrine acinar cells. Previous studies in excitable cells demonstrated… (more)

▼ Calcium is the most versatile second messenger and plays fundamental roles in orchestrating enzyme secretion in exocrine acinar cells. Previous studies in excitable cells demonstrated the existence of high Ca2+ microdomains. The major function of such microdomains is to create high local calcium concentration to activate various calcium-dependent signaling events. However, in non-excitable cells, direct evidence of such microdomains is absent. The goal of my study is to characterize the properties of high Ca2+ microdomains in acinar cells and explore its physiological relevance in the context of the secretory functions. By combining Total Internal Reflection Fluorescence Microscopy (TIRFM) technique and wide-field fluorescence imaging, I was able to quantify and compare changes in the concentration of free Ca2+ in the near membrane microdomains (?[Ca2+]PM) and in the bulk cytosol (?[Ca2+]Cyto). ?[Ca2+]PM is about 3-fold larger than ?[Ca2+]Cyto under maximal agonist stimulation, while resting [Ca2+]PM and [Ca2+]Cyto shows no difference. Near membrane microdomains also showed greater Ca2+ influx following store depletion induced either by activating surface receptor or by inhibiting SERCA pump. In response to physiological strength of stimulation, Ca2+ oscillation in the two compartments showed significantly different dynamics. The activation mechanisms of the Ca2+-induced Ca2+ release (CICR) are well established in cardiac and skeletal muscles and involves high Ca2+ microdomains. My study was the first to demonstrate the presence of CICR in the parotid acinar cell. In these cells, minimal activation of Ca2+ influx by partially depleting the stores, either by directly activating the cell surface receptor or by inhibiting SERCA, leads to an explosive release of Ca2+ from the majority of the stores, mediated presumably by RyR away from microdomains. The last part of my study is on the effects of chronic ER stress on Ca2+ signaling. The study suggests that ER stress induced by PERK mutation impeded both the efficiency and fidelity of Ca2+ signaling. My work validates the existence of near plasma membrane microdomains in non-excitable exocrine cells. The fact that [Ca2+]PM and [Ca2+]Cyto differ in many ways suggests that microdomains is the central signaling platform in these cells. Advisors/Committee Members: Bezprozvanny, Ilya.

Subjects/Keywords: Calcium; Calcium Channels; Portoid Gland

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APA (6^th Edition):

Yao, J. (2011). Ca2+ Signaling in the Near Plasma Membrane Microdomain of Non-Excitable Cells. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/864

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yao, Jian. “Ca2+ Signaling in the Near Plasma Membrane Microdomain of Non-Excitable Cells.” 2011. Thesis, University of Texas Southwestern Medical Center. Accessed February 22, 2020. http://hdl.handle.net/2152.5/864.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yao, Jian. “Ca2+ Signaling in the Near Plasma Membrane Microdomain of Non-Excitable Cells.” 2011. Web. 22 Feb 2020.

Vancouver:

Yao J. Ca2+ Signaling in the Near Plasma Membrane Microdomain of Non-Excitable Cells. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2011. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2152.5/864.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yao J. Ca2+ Signaling in the Near Plasma Membrane Microdomain of Non-Excitable Cells. [Thesis]. University of Texas Southwestern Medical Center; 2011. Available from: http://hdl.handle.net/2152.5/864

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Georgia

4. Compton, Steven Patrick. Upconversion and near infrared spectroscopy of erbium doped calcium sulfide.

Degree: PhD, Physics, 2009, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/compton_steven_p_200912_phd

► This dissertation details the fabrication process and spectroscopic characterization of erbium doped calcium sulfide as a tool for medical research and treatment. The use of… (more)

Subjects/Keywords: Calcium Sulfide

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APA (6^th Edition):

Compton, S. P. (2009). Upconversion and near infrared spectroscopy of erbium doped calcium sulfide. (Doctoral Dissertation). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/compton_steven_p_200912_phd

Chicago Manual of Style (16^th Edition):

Compton, Steven Patrick. “Upconversion and near infrared spectroscopy of erbium doped calcium sulfide.” 2009. Doctoral Dissertation, University of Georgia. Accessed February 22, 2020. http://purl.galileo.usg.edu/uga_etd/compton_steven_p_200912_phd.

MLA Handbook (7^th Edition):

Compton, Steven Patrick. “Upconversion and near infrared spectroscopy of erbium doped calcium sulfide.” 2009. Web. 22 Feb 2020.

Vancouver:

Compton SP. Upconversion and near infrared spectroscopy of erbium doped calcium sulfide. [Internet] [Doctoral dissertation]. University of Georgia; 2009. [cited 2020 Feb 22]. Available from: http://purl.galileo.usg.edu/uga_etd/compton_steven_p_200912_phd.

Council of Science Editors:

Compton SP. Upconversion and near infrared spectroscopy of erbium doped calcium sulfide. [Doctoral Dissertation]. University of Georgia; 2009. Available from: http://purl.galileo.usg.edu/uga_etd/compton_steven_p_200912_phd

Oregon State University

5. Beals, Maple Cole. Food sources of calcium : The determination of calcium in meat cooked with acid.

Degree: MS, Foods and Nutrition, 1935, Oregon State University

URL: http://hdl.handle.net/1957/26248

Subjects/Keywords: Calcium

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APA (6^th Edition):

Beals, M. C. (1935). Food sources of calcium : The determination of calcium in meat cooked with acid. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/26248

Chicago Manual of Style (16^th Edition):

Beals, Maple Cole. “Food sources of calcium : The determination of calcium in meat cooked with acid.” 1935. Masters Thesis, Oregon State University. Accessed February 22, 2020. http://hdl.handle.net/1957/26248.

MLA Handbook (7^th Edition):

Beals, Maple Cole. “Food sources of calcium : The determination of calcium in meat cooked with acid.” 1935. Web. 22 Feb 2020.

Vancouver:

Beals MC. Food sources of calcium : The determination of calcium in meat cooked with acid. [Internet] [Masters thesis]. Oregon State University; 1935. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1957/26248.

Council of Science Editors:

Beals MC. Food sources of calcium : The determination of calcium in meat cooked with acid. [Masters Thesis]. Oregon State University; 1935. Available from: http://hdl.handle.net/1957/26248

Oregon State University

6. Olson, Eric J. Calcium in the equatorial Pacific Ocean.

Degree: MS, Oceanography, 1981, Oregon State University

URL: http://hdl.handle.net/1957/27993

Subjects/Keywords: Calcium

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APA (6^th Edition):

Olson, E. J. (1981). Calcium in the equatorial Pacific Ocean. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/27993

Chicago Manual of Style (16^th Edition):

Olson, Eric J. “Calcium in the equatorial Pacific Ocean.” 1981. Masters Thesis, Oregon State University. Accessed February 22, 2020. http://hdl.handle.net/1957/27993.

MLA Handbook (7^th Edition):

Olson, Eric J. “Calcium in the equatorial Pacific Ocean.” 1981. Web. 22 Feb 2020.

Vancouver:

Olson EJ. Calcium in the equatorial Pacific Ocean. [Internet] [Masters thesis]. Oregon State University; 1981. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1957/27993.

Council of Science Editors:

Olson EJ. Calcium in the equatorial Pacific Ocean. [Masters Thesis]. Oregon State University; 1981. Available from: http://hdl.handle.net/1957/27993

University of New Mexico

7. Scullin, Chessa. Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse.

Degree: Biomedical Sciences Graduate Program, 2010, University of New Mexico

URL: https://digitalrepository.unm.edu/biom_etds/18

► Following a presynaptic action potential, there is a rapid rise of [Ca2+]i in the immediate vicinity of Ca2+ channels that triggers membrane fusion and release… (more)

▼ Following a presynaptic action potential, there is a rapid rise of [Ca2+]i in the immediate vicinity of Ca2+ channels that triggers membrane fusion and release of transmitter from vesicles within this microdomain. This presynaptic Ca2+ signal ([Ca2+]pre) then disperses to produce a residual Ca2+ ([Ca2+]res) that decays over the course of tens to hundreds of milliseconds. The [Ca2+]res has important implications in synaptic plasticity and is the basis for working memory storage. Ultimately [Ca2+]res is removed from the cytoplasm either into intracellular organelles or across the plasma membrane into the extracellular environment. Calcium influx pathways, cytoplasmic Ca2+ buffering proteins, and Ca2+ extrusion processes in rodent neurons undergo considerable change during the first postnatal month. These changes have important functional significance in short-term plasticity — in particular paired-pulse facilitation (PPF) — at presynaptic terminals where neurotransmitter release is directly dependent on the dynamics of free cytoplasmic Ca2+. To examine developmental changes in [Ca2+]res dynamics in the Schaffer collateral synapses onto CA1 pyramidal neurons in in vitro hippocampal slices, we measured the timecourse of decay of [Ca2+]res in presynaptic terminals following single and paired orthodromic stimuli in the stratum radiatum. The contribution of the slow component compared to the total decay of [Ca2+]res was reduced from >80% in newborn mice to ~50% in the more mature animals (>P24) and [Ca2+]res had a distinct slow rising component in newborn mice (<P4), which was not apparent in older mice. This transition from a slow decay in early neonatal periods to the rapid decay in adults occurred gradually over the first 4 weeks of postnatal life, and appeared to be coincident with the major period of maturation of these synapses. The first goal of this study was to investigate the role of internal stores in regulating presynaptic [Ca2+] and in synaptic plasticity during this important period of synaptic development. During this same developmental period, SNAP-25, a presynaptic vesicular release protein, undergoes changes in isoform expression. Alterations in SNAP-25 isoform expression have been linked to diseases with developmental onset such as schizophrenia, attention deficit hyperactivity disorder, and epilepsy (Corradini et al., 2009). Snap25tm2Mcw mice (Tkneo), in which this developmental change of isoform expression is modified (Bark et al., 2004), appear to retain an immature state of paired-pulse facilitation. The second goal of this study was to use these Tkneo mice as a tool to better understand the mechanisms of synaptic plasticity and to better understand how SNAP-25 regulation could underlie neurological disorders. We applied a model for paired-pulse facilitation (Schiess et al., 2006), which describes facilitation as a function of two [Ca2+]res-dependent pools of vesicles with different release probabilities. This model predicted the observed external [Ca2+]-dependent changes in… Advisors/Committee Members: Partridge, L. Donald, Wilson, Michael, Thomas, James, Hartley, Rebecca, Shuttleworth, C. William.

Subjects/Keywords: calcium; hippocampus

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APA (6^th Edition):

Scullin, C. (2010). Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/18

Chicago Manual of Style (16^th Edition):

Scullin, Chessa. “Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse.” 2010. Doctoral Dissertation, University of New Mexico. Accessed February 22, 2020. https://digitalrepository.unm.edu/biom_etds/18.

MLA Handbook (7^th Edition):

Scullin, Chessa. “Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse.” 2010. Web. 22 Feb 2020.

Vancouver:

Scullin C. Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse. [Internet] [Doctoral dissertation]. University of New Mexico; 2010. [cited 2020 Feb 22]. Available from: https://digitalrepository.unm.edu/biom_etds/18.

Council of Science Editors:

Scullin C. Development of presynaptic calcium dynamics and short-term plasticity in the SC-Ca1 synapse. [Doctoral Dissertation]. University of New Mexico; 2010. Available from: https://digitalrepository.unm.edu/biom_etds/18

8. Blaeser, Andrew S. Optical Interrogation of the Spontaneous Dynamics of Prefrontal Cortical Networks.

Degree: PhD, Physics, 2015, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:419386/

► The prefrontal cortex (PFC) is the brain region most strongly associated with many higher cognitive functions such as working memory and decision making. While decades… (more)

▼ The prefrontal cortex (PFC) is the brain region most strongly associated with many higher cognitive functions such as working memory and decision making. While decades of study have produced a wealth of data about the anatomy and physiology of the PFC, our knowledge of the mechanisms by which the PFC stores, represents and processes information is currently incomplete. Specifically, little is known about the neuronal microcircuits within the PFC that may represent the basic units underlying its various functions. A deeper understanding of the network activity of PFC will likely be critically important for understanding cognition, and for developing therapies for PFC-related disorders such as schizophrenia. The advent of functional imaging has enabled the simultaneous measurement of the activity of large numbers of neighboring neurons, setting the stage for analysis of cortical microcircuits on a spatial scale that is inaccessible by traditional electrophysiological methods. In this thesis, we use calcium imaging in acute brain slices to characterize the dynamics of networks within deep-layer medial PFC. Taking advantage of the brain slice preparation, we use pharmacological agents to manipulate two molecular systems strongly implicated in network activity: NMDA receptors and GABAA receptors. We also present a framework for analyzing the resulting movies. Whereas the majority of neurons show only sporadic activity, a subset of neurons emit spontaneous, delta-band rhythmic activity. Looking beyond the activity of individual neurons, we examine the interactions between neurons. We find that spontaneous activity under baseline conditions is weakly correlated between pairs of neurons, and that rhythmic neurons showed little coherence in their oscillations. However, we consistently observed brief bouts of synchronous activity. Using surrogate data sets, we showed that the degree of correlation and synchrony we observed could not be explained by coincidence, but must be attributed partly to network activity. Finally, we described the effects of NMDA and picrotoxin on these metrics of network dynamics, and discuss possible implications of these results for understanding the neuronal bases of cognition and brain diseases. Advisors/Committee Members: Nurmikko, Arto (Director), Stein, Derek (Reader), Connors, Barry (Reader).

Subjects/Keywords: calcium imaging

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APA (6^th Edition):

Blaeser, A. S. (2015). Optical Interrogation of the Spontaneous Dynamics of Prefrontal Cortical Networks. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:419386/

Chicago Manual of Style (16^th Edition):

Blaeser, Andrew S. “Optical Interrogation of the Spontaneous Dynamics of Prefrontal Cortical Networks.” 2015. Doctoral Dissertation, Brown University. Accessed February 22, 2020. https://repository.library.brown.edu/studio/item/bdr:419386/.

MLA Handbook (7^th Edition):

Blaeser, Andrew S. “Optical Interrogation of the Spontaneous Dynamics of Prefrontal Cortical Networks.” 2015. Web. 22 Feb 2020.

Vancouver:

Blaeser AS. Optical Interrogation of the Spontaneous Dynamics of Prefrontal Cortical Networks. [Internet] [Doctoral dissertation]. Brown University; 2015. [cited 2020 Feb 22]. Available from: https://repository.library.brown.edu/studio/item/bdr:419386/.

Council of Science Editors:

Blaeser AS. Optical Interrogation of the Spontaneous Dynamics of Prefrontal Cortical Networks. [Doctoral Dissertation]. Brown University; 2015. Available from: https://repository.library.brown.edu/studio/item/bdr:419386/

Oregon State University

9. Redelings, Elizabeth Abbott. A determination of calcium in the diets of a cooperative house and a dormitory at Oregon State College.

Degree: MS, Foods and Nutrition, 1942, Oregon State University

URL: http://hdl.handle.net/1957/26461

Subjects/Keywords: Calcium

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APA (6^th Edition):

Redelings, E. A. (1942). A determination of calcium in the diets of a cooperative house and a dormitory at Oregon State College. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/26461

Chicago Manual of Style (16^th Edition):

Redelings, Elizabeth Abbott. “A determination of calcium in the diets of a cooperative house and a dormitory at Oregon State College.” 1942. Masters Thesis, Oregon State University. Accessed February 22, 2020. http://hdl.handle.net/1957/26461.

MLA Handbook (7^th Edition):

Redelings, Elizabeth Abbott. “A determination of calcium in the diets of a cooperative house and a dormitory at Oregon State College.” 1942. Web. 22 Feb 2020.

Vancouver:

Redelings EA. A determination of calcium in the diets of a cooperative house and a dormitory at Oregon State College. [Internet] [Masters thesis]. Oregon State University; 1942. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1957/26461.

Council of Science Editors:

Redelings EA. A determination of calcium in the diets of a cooperative house and a dormitory at Oregon State College. [Masters Thesis]. Oregon State University; 1942. Available from: http://hdl.handle.net/1957/26461

10. Taylor, Jackson Richard. Cavβ1a in the Nucleus of Muscle Progenitor Cells: Mechanisms, Functions, and Implications.

Degree: 2013, Wake Forest University

URL: http://hdl.handle.net/10339/38578

► CaVbeta subunits are traditionally considered constituents of CaV complexes (CaV1or2, CaVbeta;, and CaV alpha2/delta), where they localize at the plasma membrane and serve to regulate… (more)

Subjects/Keywords: calcium

…calcium channel ChIP �� …. ��Chromatin Immunoprecipitation DHPR… …Introduction Part 1: History of Cavβ as a Cav subunit. The β subunit of the voltage gated calcium… …x28;≈ 160 kDa) and γ (≈ 33 kDa) subunits of the voltage-sensitive calcium… …voltage gated”) into calcium influx (hence “calcium channel”). Calcium influx… …voltage-gated calcium channel (permeability, gating, pharmacological sensitivity, and…

10 more images…

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APA (6^th Edition):

Taylor, J. R. (2013). Cavβ1a in the Nucleus of Muscle Progenitor Cells: Mechanisms, Functions, and Implications. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/38578

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Taylor, Jackson Richard. “Cavβ1a in the Nucleus of Muscle Progenitor Cells: Mechanisms, Functions, and Implications.” 2013. Thesis, Wake Forest University. Accessed February 22, 2020. http://hdl.handle.net/10339/38578.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Taylor, Jackson Richard. “Cavβ1a in the Nucleus of Muscle Progenitor Cells: Mechanisms, Functions, and Implications.” 2013. Web. 22 Feb 2020.

Vancouver:

Taylor JR. Cavβ1a in the Nucleus of Muscle Progenitor Cells: Mechanisms, Functions, and Implications. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10339/38578.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Taylor JR. Cavβ1a in the Nucleus of Muscle Progenitor Cells: Mechanisms, Functions, and Implications. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/38578

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

11. Anstice, Jinnie, 1976-. A microfluidic investigation of calcium oxalate crystallization.

Degree: MS, Chemistry, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/56996/

► Calcium oxalate crystallization is widely studied due to the prevalence of this substance in various biomineralization processes, especially the formation of kidney stones. Bulk crystallization… (more)

Subjects/Keywords: Calcium oxalate

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APA (6^th Edition):

Anstice, Jinnie, 1. (2018). A microfluidic investigation of calcium oxalate crystallization. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/56996/

Chicago Manual of Style (16^th Edition):

Anstice, Jinnie, 1976-. “A microfluidic investigation of calcium oxalate crystallization.” 2018. Masters Thesis, Rutgers University. Accessed February 22, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/56996/.

MLA Handbook (7^th Edition):

Anstice, Jinnie, 1976-. “A microfluidic investigation of calcium oxalate crystallization.” 2018. Web. 22 Feb 2020.

Vancouver:

Anstice, Jinnie 1. A microfluidic investigation of calcium oxalate crystallization. [Internet] [Masters thesis]. Rutgers University; 2018. [cited 2020 Feb 22]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/56996/.

Council of Science Editors:

Anstice, Jinnie 1. A microfluidic investigation of calcium oxalate crystallization. [Masters Thesis]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/56996/

Rutgers University

12. Bandali, Elhaam, 1990-. The influence of dietary fat and intestinal pH on calcium bioaccessibility: an in vitro study.

Degree: MS, Nutritional Sciences, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/51231/

► Human studies measuring true fractional calcium absorption have shown that dietary fat is a significant predictor of calcium absorption. In murine models, dietary fat also… (more)

▼ Human studies measuring true fractional calcium absorption have shown that dietary fat is a significant predictor of calcium absorption. In murine models, dietary fat also increases calcium absorption, but whether there is a differential effect with the type of fatty acid (FA) on intestinal calcium absorption is less clear. Compared to monounsaturated FAs (MUFAs), saturated FAs (SFAs) decrease lipid membrane fluidity and have a greater intestinal transit time, potentially prolonging their interaction with calcium in the gut. In addition, SFAs bind to calcium forming insoluble soaps, increasing fecal fat excretion, and reducing calcium availability for absorption. In addition, luminal factors such as a higher pH in the GI tract could influence calcium absorption such as with certain medications or achlorhydria. The TNO gastrointestinal model (TIM-1) replicates the physiological activities occurring in the lumen of the stomach, duodenum, jejunum, and ileum and is used to study biological events preceding nutrient absorption (i.e., bioaccessibility). In this study, we examined two high fat formulas (SFA or MUFA enriched) compared to low fat and controlled for calcium (500 mg) and other micronutrients during a 5-hr experiment. Calcium bioaccessibility (CaB) was greater for the high compared to low fat test meal in the jejunum (p = 0.001). In addition, CaB with the SFA alone was higher than either LFD or MUFA (p < 0.01). However, there was no interaction between diet and CaB in the ileum or ileal efflux. During high gastrointestinal pH, CaB was similar between diets in the jejunum and ileum, and there was a trend for increasing non-bioaccessible calcium over time (p = 0.058). Furthermore, CaB was 90% (p = 0.003), 91% (p = 0.036), and 94% (p = 0.001) lower in the jejunum, ileum, and ileal efflux, respectively at high pH compared to normal gastrointestinal conditions. These findings suggest a dramatically lower CaB under high pH conditions, having implications for a wide range of patients with gastrointestinal disorders. In addition, the higher Ca absorption associated with a high fat diet found previously, may be partially explained by an increased CaB. Advisors/Committee Members: Shapses, Sue (chair).

Subjects/Keywords: Calcium – Metabolism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bandali, Elhaam, 1. (2016). The influence of dietary fat and intestinal pH on calcium bioaccessibility: an in vitro study. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/51231/

Chicago Manual of Style (16^th Edition):

Bandali, Elhaam, 1990-. “The influence of dietary fat and intestinal pH on calcium bioaccessibility: an in vitro study.” 2016. Masters Thesis, Rutgers University. Accessed February 22, 2020. https://rucore.libraries.rutgers.edu/rutgers-lib/51231/.

MLA Handbook (7^th Edition):

Bandali, Elhaam, 1990-. “The influence of dietary fat and intestinal pH on calcium bioaccessibility: an in vitro study.” 2016. Web. 22 Feb 2020.

Vancouver:

Bandali, Elhaam 1. The influence of dietary fat and intestinal pH on calcium bioaccessibility: an in vitro study. [Internet] [Masters thesis]. Rutgers University; 2016. [cited 2020 Feb 22]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51231/.

Council of Science Editors:

Bandali, Elhaam 1. The influence of dietary fat and intestinal pH on calcium bioaccessibility: an in vitro study. [Masters Thesis]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51231/

University of Florida

13. Lopez, David. An Investigation Into the Effects of Calcium Phosphate and Calcium Carbonate on Gut Microbiota in Healthy Young Adults.

Degree: 2013, University of Florida

URL: http://ufdc.ufl.edu/AA00061313

► This study investigated the effects of calcium carbonate and calcium phosphate on gut microbiota within a healthy young adult population. The aim of the study… (more)

Subjects/Keywords: Dietary supplements; Calcium carbonate; Calcium phosphate; Lactobacillus

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APA (6^th Edition):

Lopez, D. (2013). An Investigation Into the Effects of Calcium Phosphate and Calcium Carbonate on Gut Microbiota in Healthy Young Adults. (Thesis). University of Florida. Retrieved from http://ufdc.ufl.edu/AA00061313

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lopez, David. “An Investigation Into the Effects of Calcium Phosphate and Calcium Carbonate on Gut Microbiota in Healthy Young Adults.” 2013. Thesis, University of Florida. Accessed February 22, 2020. http://ufdc.ufl.edu/AA00061313.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lopez, David. “An Investigation Into the Effects of Calcium Phosphate and Calcium Carbonate on Gut Microbiota in Healthy Young Adults.” 2013. Web. 22 Feb 2020.

Vancouver:

Lopez D. An Investigation Into the Effects of Calcium Phosphate and Calcium Carbonate on Gut Microbiota in Healthy Young Adults. [Internet] [Thesis]. University of Florida; 2013. [cited 2020 Feb 22]. Available from: http://ufdc.ufl.edu/AA00061313.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lopez D. An Investigation Into the Effects of Calcium Phosphate and Calcium Carbonate on Gut Microbiota in Healthy Young Adults. [Thesis]. University of Florida; 2013. Available from: http://ufdc.ufl.edu/AA00061313

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

14. Thomas, Balbir. A model of mitochonrial calcium induced calcium release.

Degree: PhD, Biophysics, 2007, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1190053132

► Cytoplasmic calcium plays a dual role in cellular physiology. On one hand it acts as a second messenger in intra-cellular signalling, and on the other… (more)

Subjects/Keywords: Mitochondrial Calcium Induced Calcium Release; MCICR

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APA (6^th Edition):

Thomas, B. (2007). A model of mitochonrial calcium induced calcium release. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1190053132

Chicago Manual of Style (16^th Edition):

Thomas, Balbir. “A model of mitochonrial calcium induced calcium release.” 2007. Doctoral Dissertation, The Ohio State University. Accessed February 22, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1190053132.

MLA Handbook (7^th Edition):

Thomas, Balbir. “A model of mitochonrial calcium induced calcium release.” 2007. Web. 22 Feb 2020.

Vancouver:

Thomas B. A model of mitochonrial calcium induced calcium release. [Internet] [Doctoral dissertation]. The Ohio State University; 2007. [cited 2020 Feb 22]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1190053132.

Council of Science Editors:

Thomas B. A model of mitochonrial calcium induced calcium release. [Doctoral Dissertation]. The Ohio State University; 2007. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1190053132

University of Western Australia

15. Athanassiadis, Basil. An in vitro investigation into the antimicrobial activity of some endodontic medicaments and their bases using agar diffusion, biofilm testing and medicament inactivation by dentine.

Degree: MS, 2007, University of Western Australia

URL: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=9981&local_base=GEN01-INS01

►

There is no question that micro-organisms are at the centre of the cause of pulpal and periradicular pathoses. Antimicrobial agents have been used in endodontic… (more)

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There is no question that micro-organisms are at the centre of the cause of pulpal and periradicular pathoses. Antimicrobial agents have been used in endodontic therapy for more than a century. It is well known that after instrumentation and irrigation some type of further disinfection is required to enhance the chances for treatment success; hence various types of medicaments have been used over the last century. Currently calcium hydroxide is the most commonly used medicament but others include antibiotic/steroid combinations of which Ledermix paste is the most popular. Although these ingredients are the active components of the medicaments, their vehicles play an important role in determining the ionic dissociation of the active components as well as the handling properties of the product. This study used three different testing models to compare, by in vitro means, the efficacy of a number of medicaments in terms of their antimicrobial spectrum, medicament inactivation and ability to penetrate Enterococcus faecalis biofilms. Their bases were also tested separately to establish what effect these components had. The medicaments used in each test model were Ledermix paste, Pulpdent paste, Ultracal paste, and a 50:50 mixture of Ledermix and Pulpdent pastes, while the bases tested included methyl cellulose and water, polyethylene glycol (PEG), and PEG combined with zinc oxide, calcium chloride and the remainder of ingredients which form the base for Ledermix paste. Well diffusion assays were used to test the antimicrobial action of the above commercial products and their bases. The zones of inhibition were recorded and compared to assess the relative antimicrobial actions. Each medicament and base was also applied to biofilms of E. faecalis generated on cellulose nitrate membrane filters. Each of these biofilms were transferred to a saline solution which was seeded onto agar plates and then the colony forming units were counted to determine the number of bacterial cells destroyed. The final experiment investigated the antimicrobial effect of some current medicaments and their bases on E. faecalis in the presence of dentine, and evaluated the extent of inactivation of the antibacterial activity by dentine. The results of the three studies showed that none of the bases had any major antimicrobial effects against the bacteria tested. The combination of Ledermix paste and Pulpdent paste produced the best antibacterial results in the agar diffusion assay. Pulpdent and the Ledermix/Pulpdent combination produced the highest percentage "kills" in E. faecalis biofilms, and this effect was also repeated whilst in the presence of dentine. Taken as a whole, the results of this series of studies suggest that of the medicaments tested (Ledermix, Pulpdent, Ledermix/Pulpdent 50/50) the calcium hydroxide containing medicaments have the greatest antimicrobial properties.

There is no question that micro-organisms are at the centre of the cause of pulpal and periradicular pathoses. Antimicrobial agents have been used in endodontic…

Subjects/Keywords: Endodontics; Calcium hydroxide; Endodontic medicaments; Calcium nydroxide

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Athanassiadis, B. (2007). An in vitro investigation into the antimicrobial activity of some endodontic medicaments and their bases using agar diffusion, biofilm testing and medicament inactivation by dentine. (Masters Thesis). University of Western Australia. Retrieved from http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=9981&local_base=GEN01-INS01

Chicago Manual of Style (16^th Edition):

Athanassiadis, Basil. “An in vitro investigation into the antimicrobial activity of some endodontic medicaments and their bases using agar diffusion, biofilm testing and medicament inactivation by dentine.” 2007. Masters Thesis, University of Western Australia. Accessed February 22, 2020. http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=9981&local_base=GEN01-INS01.

MLA Handbook (7^th Edition):

Athanassiadis, Basil. “An in vitro investigation into the antimicrobial activity of some endodontic medicaments and their bases using agar diffusion, biofilm testing and medicament inactivation by dentine.” 2007. Web. 22 Feb 2020.

Vancouver:

Athanassiadis B. An in vitro investigation into the antimicrobial activity of some endodontic medicaments and their bases using agar diffusion, biofilm testing and medicament inactivation by dentine. [Internet] [Masters thesis]. University of Western Australia; 2007. [cited 2020 Feb 22]. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=9981&local_base=GEN01-INS01.

Council of Science Editors:

Athanassiadis B. An in vitro investigation into the antimicrobial activity of some endodontic medicaments and their bases using agar diffusion, biofilm testing and medicament inactivation by dentine. [Masters Thesis]. University of Western Australia; 2007. Available from: http://repository.uwa.edu.au:80/R/?func=dbin-jump-full&object_id=9981&local_base=GEN01-INS01

Macquarie University

16. Colas, Bruno. Structural constraints on the crystallisation of amorphous calcium carbonate.

Degree: 2017, Macquarie University

URL: http://hdl.handle.net/1959.14/1261526

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Empirical thesis.

"The Bragg Institute, Australian Nuclear Science and Technology Organisation ; Australian Research Council Centre of Excellence for Core to Crust Fluid Systems (CCFS)… (more)

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Empirical thesis.

"The Bragg Institute, Australian Nuclear Science and Technology Organisation ; Australian Research Council Centre of Excellence for Core to Crust Fluid Systems (CCFS) and GEMOC" – at foot of title.

Bibliography: pages 133-149.

1. Introduction – 2. Calcium Carbonate preparation and characterisation – 3. Kinetics of particle growth and crystallisation of calcium carbonate – 4. Determination of the atomic structure of ACC – 5. Conclusion – Appendices – List of symbols – Bibliograohy.

Amorphous calcium carbonate (ACC) is a biogenic precursor of calcium carbonates forming shells and skeletons of marine organisms which are key components of the whole marine environment. Understanding carbonate formation is an essential prerequisite to quantify the effect climate change and pollution have on marine population, to build biogenic climate proxy archives and to design novel functional materials by biomimetism.

Water is a critical component of the structure of ACC and a component controlling the stability of the amorphous phase. Addition of small amounts of magnesium (1–10% of the calcium content) is known to promote the stability of ACC, presumably through stabilization of the hydrogen bonding network. Understanding the hydrogen bonding network in ACC is fundamental to understand the stability of ACC.

I successfully developed a synthesis protocol to make stable Amorphous Calcium Carbonate.This study describes the sample synthesis and characterization methods. This is followed by a description of the nucleation and crystallisation of calcium carbonate, along a non-classical pathway. The results are parameterised in terms of kinetics and final product as a function of magnesium doping.

The approach used in this study to determine the atomic structure of ACC is to use Monte-Carlo simulations, using the Empirical Potential Structure Refinement program, constrained by X-ray and neutron scattering data. X-ray data are suitable for determining Ca, Mg and O correlations, and neutron data give information on the hydrogen / deuterium (as the interaction of X-rays with hydrogen is too low for us to be able to constrain hydrogen atom positions with only X-rays). The final atomic model includes water molecule positions.

This new approach is used to constrain current novel kinetic models, shed light on the role of impurities and provide a basis for understanding biogenic systems in general.

1 online resource (xx, 149 pages) illustrations (some colour)

Advisors/Committee Members: Macquarie University. Department of Earth and Planetary Sciences, Australian Nuclear Science and Technology Organisation, ARC Centre of Excellence for Core to Crust Fluid Systems (CCFS).

Subjects/Keywords: Calcium carbonate; Crystallization; amorphous calcium carbonate; crystallisation

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APA (6^th Edition):

Colas, B. (2017). Structural constraints on the crystallisation of amorphous calcium carbonate. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1261526

Chicago Manual of Style (16^th Edition):

Colas, Bruno. “Structural constraints on the crystallisation of amorphous calcium carbonate.” 2017. Doctoral Dissertation, Macquarie University. Accessed February 22, 2020. http://hdl.handle.net/1959.14/1261526.

MLA Handbook (7^th Edition):

Colas, Bruno. “Structural constraints on the crystallisation of amorphous calcium carbonate.” 2017. Web. 22 Feb 2020.

Vancouver:

Colas B. Structural constraints on the crystallisation of amorphous calcium carbonate. [Internet] [Doctoral dissertation]. Macquarie University; 2017. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/1959.14/1261526.

Council of Science Editors:

Colas B. Structural constraints on the crystallisation of amorphous calcium carbonate. [Doctoral Dissertation]. Macquarie University; 2017. Available from: http://hdl.handle.net/1959.14/1261526

17. Torrente, Angelo. Rôle de la signalisation calcique dans la génération et régulation de l’activité pacemaker du cœur : Role of calcium handling in the genesis and regulation of heart pacemaker activity.

Degree: Docteur es, Physiologie, 2011, Université Montpellier I

URL: http://www.theses.fr/2011MON1T023

►

Les pathologies du nœud sino-atrial provoquent un dysfonctionnement intrinsèque de l'automaticité de ce tissu. La maladie, l'âge ou une anomalie génétique peuvent être la cause… (more)

▼

Les pathologies du nœud sino-atrial provoquent un dysfonctionnement intrinsèque de l'automaticité de ce tissu. La maladie, l'âge ou une anomalie génétique peuvent être la cause d'un dérèglement de la fréquence cardiaque associé à la bradycardie ou la dysfonction atrio-ventriculire. Sans intervention médicale cette pathologie peut conduire à l'arrêt cardiaque. Les pathologies touchant le sinus sont fréquentes, avec une occurrence accrue dans la population âgée. Ainsi, avec le vieillissement des populations occidentales il devient primordial de mieux comprendre les mécanismes générant l'activité automatique du cœur. Les nombreuses études déjà réalisées dans ce domaine ont conduit à une forte controverse entre deux modèles explicatifs des mécanismes pacemaker. Dans ce contexte, j'ai étudié au cours de cette thèse le rôle joué par les canaux calciques Cav1.3 dans la génération de l'activité pacemaker. Afin de distinguer et expliquer le rôle des différents canaux ioniques impliqués dans le mécanisme pacemaker nous avons utilisé une combinaison d'outils pharmacologiques et plusieurs souches de souris transgéniques dont les gènes impliqués dans l'activité pacemaker étaient inactivés ou leur fonction modifiée. Dans le but de constituer un nouveau cadre d'interprétation du mécanisme pacemaker, plusieurs approches expérimentales ont été utilisées. L'activité pacemaker a été étudié dans 3 systèmes au niveau de complexité croissant: des cellules sino-atriales isolées, des tissus sino-atriales entiers et des animaux vivants. Ces différentes approches ont permis d'obtenir des résultats probants et ouvrent la voie à une meilleure compréhension de l'automaticité. En conclusion de cette thèse, nous proposons un cadre intégratif des modèles préexistants, dans lequel les canaux de la membrane cytoplasmique et les libérations de calcium interagissent pour générer un mécanisme pacemaker complexe.

The “sick sinus syndrome” has been defined as an intrinsic dysfunction of the heart Sino-atrial node to perform its pacemaking function. Disease, ageing, or gene defects may cause sinus dysfunctions, ranging from rhythm disturbance to bradycardia, sinus pauses, sinus arrest, and arrhythmias. Without medical intervention these dysfunctions can result in heart block. Sick sinus syndrome is a common pathology, with an increased penetration in the elder population. In the light of the actual increase of elderly in western population, a better comprehension of the mechanism generating spontaneous automaticity appears fundamental. Several investigations have been already carried out in the field of automaticity, leading to a heated controversy between two models of the pacemaker mechanism. In the light this controversy, we investigated the role of Ca2+ channels in generating pacemaker activity. In order to discern and explain the roles of different ion channel actors already implicated in the complex pacemaker machinery we used a combination of pharmacological tools and a variety of transgenic mice. These mice present genetic inactivation or…

Advisors/Committee Members: Mangoni, Matteo (thesis director).

Subjects/Keywords: Cœur; Calcium; Pacemaker; Heart; Calcium; Pacemaker

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APA (6^th Edition):

Torrente, A. (2011). Rôle de la signalisation calcique dans la génération et régulation de l’activité pacemaker du cœur : Role of calcium handling in the genesis and regulation of heart pacemaker activity. (Doctoral Dissertation). Université Montpellier I. Retrieved from http://www.theses.fr/2011MON1T023

Chicago Manual of Style (16^th Edition):

Torrente, Angelo. “Rôle de la signalisation calcique dans la génération et régulation de l’activité pacemaker du cœur : Role of calcium handling in the genesis and regulation of heart pacemaker activity.” 2011. Doctoral Dissertation, Université Montpellier I. Accessed February 22, 2020. http://www.theses.fr/2011MON1T023.

MLA Handbook (7^th Edition):

Torrente, Angelo. “Rôle de la signalisation calcique dans la génération et régulation de l’activité pacemaker du cœur : Role of calcium handling in the genesis and regulation of heart pacemaker activity.” 2011. Web. 22 Feb 2020.

Vancouver:

Torrente A. Rôle de la signalisation calcique dans la génération et régulation de l’activité pacemaker du cœur : Role of calcium handling in the genesis and regulation of heart pacemaker activity. [Internet] [Doctoral dissertation]. Université Montpellier I; 2011. [cited 2020 Feb 22]. Available from: http://www.theses.fr/2011MON1T023.

Council of Science Editors:

Torrente A. Rôle de la signalisation calcique dans la génération et régulation de l’activité pacemaker du cœur : Role of calcium handling in the genesis and regulation of heart pacemaker activity. [Doctoral Dissertation]. Université Montpellier I; 2011. Available from: http://www.theses.fr/2011MON1T023

18. Kozaily, Jad. Structure et dynamique d'aluminosilicates de calcium fondus : Structure and dynamics of calcium aluminosilicate melts.

Degree: Docteur es, Sciences des matériaux, 2012, Université d'Orléans

URL: http://www.theses.fr/2012ORLE2003

►

L’étude des silicates fondus présente un intérêt dans divers domaines de recherche comme la géologie ou la fabrication des verres avec des applications technologiques importantes… (more)

▼

L’étude des silicates fondus présente un intérêt dans divers domaines de recherche comme la géologie ou la fabrication des verres avec des applications technologiques importantes telles que par exemple, le confinement des déchets nucléaires. Ces recherches demandent des informations fondamentales sur la structure et la dynamique de ces liquides au niveau microscopique mais l’acquisition des données est très souvent limitée par les températures de fusion élevées des composés étudiés. Notre travail s’est donc basé sur l’utilisation de techniques sans contact afin de s’affranchir de cette difficulté. Dans le cadre de cette thèse, nous nous sommes intéressés à l’étude des propriétés structurales et dynamiques de divers aluminosilicates de calcium (CAS) fondus. Pour cela, nous avons développé un dispositif utilisant la lévitation aérodynamique afin d’effectuer des expériences de diffusion quasi-élastique des neutrons. En combinant ces mesures avec la diffusion inélastique des rayons X, nous avons pu obtenir des résultats sur la dynamique microscopique des CAS à l’état liquide ainsi que dans le régime de surfusion. En particulier, nous avons pu déterminer l’évolution de la viscosité avec la température et les coefficients de diffusion cohérents. Nous avons pu aussi étudier l’évolution de la dynamique de ces verres en fonction de l’augmentation de la quantité de silice dans la composition. En parallèle de nos travaux sur la dynamique, nous avons aussi réalisé des expériences de diffraction de neutrons et de rayons X sur les mêmes compositions et températures afin d’examiner l’ordre atomique local et essayer de le corréler aux propriétés dynamiques observées.

Because of their interesting properties as glass-forming systems, molten silicates play an important role in the geology of the Earth’s crust and mantle and are also of industrial interest for nuclear waste treatment. Research in these areas requires fundamental information on the microscopic structure and dynamics of silicate melts, but such measurements are hampered by the very high melting points of these systems. By extending the technique of aerodynamic levitation to inelastic neutron scattering, and also making use of inelastic synchrotron x-ray scattering, we have obtained results on the microscopic dynamics of silicates both above the melting point and in the supercooled regime. In particular, we have determined the temperature evolution of the viscosity and diffusion coefficient of calcium aluminosilicates, and thereby quantified the decrease in fragility of this glass-forming system as a function of increasing silica content. In parallel with our dynamical studies, we have performed x-ray and neutron diffraction experiments on the same compositions and temperatures in order to examine the local chemical order pertinent to the observed dynamical properties.

Advisors/Committee Members: Hennet, Louis (thesis director).

Subjects/Keywords: Calcium aluminosilicates; Lévitation aérodynamique; Calcium aluminosilicates; Levitation

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APA (6^th Edition):

Kozaily, J. (2012). Structure et dynamique d'aluminosilicates de calcium fondus : Structure and dynamics of calcium aluminosilicate melts. (Doctoral Dissertation). Université d'Orléans. Retrieved from http://www.theses.fr/2012ORLE2003

Chicago Manual of Style (16^th Edition):

Kozaily, Jad. “Structure et dynamique d'aluminosilicates de calcium fondus : Structure and dynamics of calcium aluminosilicate melts.” 2012. Doctoral Dissertation, Université d'Orléans. Accessed February 22, 2020. http://www.theses.fr/2012ORLE2003.

MLA Handbook (7^th Edition):

Kozaily, Jad. “Structure et dynamique d'aluminosilicates de calcium fondus : Structure and dynamics of calcium aluminosilicate melts.” 2012. Web. 22 Feb 2020.

Vancouver:

Kozaily J. Structure et dynamique d'aluminosilicates de calcium fondus : Structure and dynamics of calcium aluminosilicate melts. [Internet] [Doctoral dissertation]. Université d'Orléans; 2012. [cited 2020 Feb 22]. Available from: http://www.theses.fr/2012ORLE2003.

Council of Science Editors:

Kozaily J. Structure et dynamique d'aluminosilicates de calcium fondus : Structure and dynamics of calcium aluminosilicate melts. [Doctoral Dissertation]. Université d'Orléans; 2012. Available from: http://www.theses.fr/2012ORLE2003

University of Adelaide

19. Ball, Christine June. Calcium channel distribution in the arterial vascular tree and its relation to function.

Degree: 2010, University of Adelaide

URL: http://hdl.handle.net/2440/63325

► Clinical evidence in microvascular disease suggests that T-type Ca⁺⁺ channel blockers (CCBs) have benefits over conventional L-type CCBs, however the basis for this remains largely… (more)

▼ Clinical evidence in microvascular disease suggests that T-type Ca⁺⁺ channel blockers (CCBs) have benefits over conventional L-type CCBs, however the basis for this remains largely unknown. The objective of this study was to examine vascular reactivity utilising both pharmacological and molecular techniques. This thesis is composed of three sections including (A) an Introduction, (B) Functional Vascular Studies and (C) Molecular Vascular Studies. Section A summarised fundamental principles of the vasculature including an outline of the vascular system, vascular physiology, vascular cell biology, regulation of cytosolic Ca⁺⁺ and vascular pathophysiology. Section B utilised isolated vessels and wire myography to determine the effect of pre-treatment with L-type CCBs (verapamil and nifedipine) and combined L- and T-type CCBs (mibefradil and efonidipine) on endothelin-1 (Et-1) and K⁺-mediated contractile responses in large (rat aorta) and small (rat mesenteric and human subcutaneous) vessels. All four CCBs inhibited both Et-1 and K⁺-mediated contractile responses to a similar extent in large rat vessels, however in rat microvessels the combined L- and T-channel blockers produced significantly greater inhibition of contraction than L-channel blockers alone. The significance of this differential T-channel effect in microvessels was further supported by: (1) demonstration of divergent CCB responses in human microvessels, (2) incremental inhibition of constrictor responses with a combined L- and T-CCB despite maximal L-channel blockade, (3) utilisation of structurally diverse CCBs with varied affinity for L- and T-channels, (6) use of pharmacodynamically and therapeutically appropriate CCB concentrations, (7) confirmation of contractile agonist independent responses, (8) consistent results even in the presence of an altered microvascular physiology in the form of chronic Et-1 activation and (9) exclusion of an endothelium-dependent mechanism. Section C utilised the molecular techniques of quantitative polymerase chain reaction (PCR) and ratiometric western blotting to examine the distribution of the pore-forming subunits Caᵥ1.2, Caᵥ3.1 and 3.2 in both large (rat aorta) and small (rat mesenteric) vessels. The PCR data was equivocal with no difference noted in the distribution of the L- and T-channels between large and small vessels. In contrast to this, quantitative western blot analysis revealed that while there is a similar distribution of the three subunits in the large vessel, there is a significantly increased expression of both T-channel pore-forming subunits in microvessels (Caᵥ3.1: 112 ± 38%*, Caᵥ3.2: 168 ± 48%* relative to L-channel expression, *p<0.05). Considered together these ‘functional’ and ‘structural’ studies indicate the important role of the Ca⁺⁺ T-channel in regulating contractile responses in the microvasculature and their therapeutic potential. Advisors/Committee Members: Beltrame, John Francis (advisor), Saint, David Albert (advisor), Wilson, David Peter Murray (advisor), School of Medicine (school).

Subjects/Keywords: calcium; vasculature; microvasculature; calcium channel blocker

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APA (6^th Edition):

Ball, C. J. (2010). Calcium channel distribution in the arterial vascular tree and its relation to function. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/63325

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ball, Christine June. “Calcium channel distribution in the arterial vascular tree and its relation to function.” 2010. Thesis, University of Adelaide. Accessed February 22, 2020. http://hdl.handle.net/2440/63325.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ball, Christine June. “Calcium channel distribution in the arterial vascular tree and its relation to function.” 2010. Web. 22 Feb 2020.

Vancouver:

Ball CJ. Calcium channel distribution in the arterial vascular tree and its relation to function. [Internet] [Thesis]. University of Adelaide; 2010. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2440/63325.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ball CJ. Calcium channel distribution in the arterial vascular tree and its relation to function. [Thesis]. University of Adelaide; 2010. Available from: http://hdl.handle.net/2440/63325

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas Southwestern Medical Center

20. Ozkan, Emin D. Study of Presynaptic Calcium Channels and a Novel Calcium Channel Calhm1.

Degree: 2010, University of Texas Southwestern Medical Center

URL: http://hdl.handle.net/2152.5/815

► Calcium signaling is essential for all cellular processes. In brain these processes include basic synaptic transmission, modification of established synapses, elimination of synapses as well… (more)

Subjects/Keywords: Calcium Channels; Calcium Signaling; Synaptic Transmission

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APA (6^th Edition):

Ozkan, E. D. (2010). Study of Presynaptic Calcium Channels and a Novel Calcium Channel Calhm1. (Thesis). University of Texas Southwestern Medical Center. Retrieved from http://hdl.handle.net/2152.5/815

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ozkan, Emin D. “Study of Presynaptic Calcium Channels and a Novel Calcium Channel Calhm1.” 2010. Thesis, University of Texas Southwestern Medical Center. Accessed February 22, 2020. http://hdl.handle.net/2152.5/815.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ozkan, Emin D. “Study of Presynaptic Calcium Channels and a Novel Calcium Channel Calhm1.” 2010. Web. 22 Feb 2020.

Vancouver:

Ozkan ED. Study of Presynaptic Calcium Channels and a Novel Calcium Channel Calhm1. [Internet] [Thesis]. University of Texas Southwestern Medical Center; 2010. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2152.5/815.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ozkan ED. Study of Presynaptic Calcium Channels and a Novel Calcium Channel Calhm1. [Thesis]. University of Texas Southwestern Medical Center; 2010. Available from: http://hdl.handle.net/2152.5/815

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

21. Njegic, Alexandra Maria. Investigation of the function of PMCA1 in physiological and pathological angiogenesis.

Degree: 2019, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322686

► Angiogenesis occurs under physiological and pathological conditions and the ability to manipulate vessel growth makes it a promising therapeutic target; however, pro-angiogenic therapies have failed… (more)

▼ Angiogenesis occurs under physiological and pathological conditions and the ability to manipulate vessel growth makes it a promising therapeutic target; however, pro-angiogenic therapies have failed to translate successfully into the clinic therefore more therapeutic options are required. One such novel target are the plasma membrane calcium ATPases (PMCAs), with PMCA4 shown to negatively regulate angiogenesis both in vitro and in vivo. The PMCAs (PMCA1-4) act to extrude Ca2+ from the cytosol into the extracellular space and can also mediate intracellular signalling. Given this role for PMCA4 in angiogenesis we hypothesised that PMCA1, which is also present in endothelial cells, may play a role in angiogenesis. In this study, the contribution of PMCA1 to physiological angiogenesis was assessed using both in vitro and in vivo methods. To determine if PMCA1 plays a role in angiogenesis in vitro, siRNA-mediated ATP2B1 knockdown was performed in human umbilical vein endothelial cells (HUVECs) which were then used to determine changes to endothelial cell biology and angiogenic characteristics. Knockdown of PMCA1 in HUVECs led to an increase in basal intracellular Ca2+, a reduction in cell viability and impaired VEGF-mediated tubule formation. Mechanistically, preliminary work identified changes to proteins involved in regulation of the eukaryotic cell cycle; loss of PMCA1 leads to a reduction in 5 out of 6 core components of the mini chromosome complex. In addition, to determine the effect of PMCA1 on angiogenesis in vivo, a novel mouse line was generated using the pan-endothelial transgene Tie2 Cre (PMCA1Tie2). These mice are viable and display no overt phenotype under basal conditions; however, the extent of PMCA1 knockdown in endothelial cells from PMCA1Tie2 mice was only 30%. Furthermore, when subject to surgical pressure-overload induced hypertrophy, PMCA1Tie2 mice show a similar extent of cardiac remodelling when compared to littermate controls but have increased levels of the pro-angiogenic protein RCAN1.4. Overall, PMCA1 is required for effective VEGF-mediated angiogenesis and endothelial cell viability in vitro and loss of PMCA1 leads to downregulation of cell cycle components. However, the understanding of the contribution of PMCA1 to physiological and pathological angiogenesis in vivo is still not conclusive; the partial endothelial knockout achieved in this study suggests that endothelial cells may require PMCA1 in order to function normally, as such, the complete ablation of endothelial PMCA1 may not be achievable in vivo. Advisors/Committee Members: SHIELS, HOLLY HA, Cartwright, Elizabeth, Shiels, Holly.

Subjects/Keywords: Angiogenesis; Plasma membrane calcium ATPase1; Hypertrophy; Calcium

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APA (6^th Edition):

Njegic, A. M. (2019). Investigation of the function of PMCA1 in physiological and pathological angiogenesis. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322686

Chicago Manual of Style (16^th Edition):

Njegic, Alexandra Maria. “Investigation of the function of PMCA1 in physiological and pathological angiogenesis.” 2019. Doctoral Dissertation, University of Manchester. Accessed February 22, 2020. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322686.

MLA Handbook (7^th Edition):

Njegic, Alexandra Maria. “Investigation of the function of PMCA1 in physiological and pathological angiogenesis.” 2019. Web. 22 Feb 2020.

Vancouver:

Njegic AM. Investigation of the function of PMCA1 in physiological and pathological angiogenesis. [Internet] [Doctoral dissertation]. University of Manchester; 2019. [cited 2020 Feb 22]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322686.

Council of Science Editors:

Njegic AM. Investigation of the function of PMCA1 in physiological and pathological angiogenesis. [Doctoral Dissertation]. University of Manchester; 2019. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322686

University of Georgia

22. Srinivasamoorthy, Ganesh. Imaging intercellular calcium waves in the developing nervous system of zebrafish.

Degree: MS, Biological Engineering, 2008, University of Georgia

URL: http://purl.galileo.usg.edu/uga_etd/srinivasamoorthy_ganesh_200808_ms

► Several critical developmental events in the brain are believed to be regulated by spontaneous calcium waves. Commonly used calcium imaging methodologies have not been successful… (more)

Subjects/Keywords: Intercellular calcium waves

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APA (6^th Edition):

Srinivasamoorthy, G. (2008). Imaging intercellular calcium waves in the developing nervous system of zebrafish. (Masters Thesis). University of Georgia. Retrieved from http://purl.galileo.usg.edu/uga_etd/srinivasamoorthy_ganesh_200808_ms

Chicago Manual of Style (16^th Edition):

Srinivasamoorthy, Ganesh. “Imaging intercellular calcium waves in the developing nervous system of zebrafish.” 2008. Masters Thesis, University of Georgia. Accessed February 22, 2020. http://purl.galileo.usg.edu/uga_etd/srinivasamoorthy_ganesh_200808_ms.

MLA Handbook (7^th Edition):

Srinivasamoorthy, Ganesh. “Imaging intercellular calcium waves in the developing nervous system of zebrafish.” 2008. Web. 22 Feb 2020.

Vancouver:

Srinivasamoorthy G. Imaging intercellular calcium waves in the developing nervous system of zebrafish. [Internet] [Masters thesis]. University of Georgia; 2008. [cited 2020 Feb 22]. Available from: http://purl.galileo.usg.edu/uga_etd/srinivasamoorthy_ganesh_200808_ms.

Council of Science Editors:

Srinivasamoorthy G. Imaging intercellular calcium waves in the developing nervous system of zebrafish. [Masters Thesis]. University of Georgia; 2008. Available from: http://purl.galileo.usg.edu/uga_etd/srinivasamoorthy_ganesh_200808_ms

Victoria University of Wellington

23. Rahner, Nils. Inorganic Polymers (Geopolymers) as Potential Bioactive Materials.

Degree: 2009, Victoria University of Wellington

URL: http://hdl.handle.net/10063/952

► The primary aim of this project was to synthesise potassium activated geopolymer composites with bioactivity, and this was realised by adding 10wt% of calcium hydroxide,… (more)

▼ The primary aim of this project was to synthesise potassium activated geopolymer composites with bioactivity, and this was realised by adding 10wt% of calcium hydroxide, nano-structured calcium silicate or calcium phosphate to the geopolymer matrix. The synthesised samples were cured at 40'C then heated to 550'C and 600'C to reduce their alkalinity. Tensile strength was measured by diametral compression. The effect of exposure to simulated body fluid (SBF) was determined by x-ray diffractometry (XRD), 27Al, 29Si and 43Ca nuclear magnetic resonance spectroscopy with magic angle spinning (MAS NMR), pH measurements, inductively coupled plasma (ICP), scanning electron microscopy (SEM) and energy dispersive x-ray analysis (EDS). XRD, 27Al and 29Si MAS NMR confirmed that all the samples retained their structural characteristics of a true aluminosilicate geopolymer, even after heating and exposure to SBF. EDS examination of the calcium-containing geopolymer composites showed that the calcium distribution was generally homogeneous. Exposure of the geopolymer composites to SBF at body temperature, was used to simulate the behaviour of the geopolymer composites in blood plasma. XRD and SEM/ EDS analysis showed that the geopolymers containing calcium hydroxide and calcium silicate formed hydroxyl apatite (HA) and carbonate hydroxyl apatite (HCA) after their exposure to SBF, indicating a degree of bioactivity. The absorption of calcium and phosphorus from the SBF and the observation of nano crystals rich in these elements provide some evidence of bioactive phases in the composite containing calcium phosphate and the reference geopolymer. The reference and the calcium phosphate geopolymer (both heated to 600XC) produced the lowest pH (ca.8) in the SBF. ICP analysis of the SBF after exposure shows that most of the aluminium remains in the geopolymer structure. The greatest release of aluminium (< 2.7 ppm after 168 hours) was found for the calcium hydroxide geopolymer (heated to 600'C). Diametral compression testing showed that the strength of the calcium phosphate-containing geopolymer heated to 550'C (4.17 MPa) is comparable with that of Bioglass(R)(5.56 MPa), currently used as a bio-material. Although none of the composites are ideal in all respects, they show sufficient promise to suggest that with further refinement, geopolymer materials may well be become candidates as bioactive ceramics. Advisors/Committee Members: MacKenzie, Kenneth.

Subjects/Keywords: Calcium; Aluminium; Biomaterials

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APA (6^th Edition):

Rahner, N. (2009). Inorganic Polymers (Geopolymers) as Potential Bioactive Materials. (Masters Thesis). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/952

Chicago Manual of Style (16^th Edition):

Rahner, Nils. “Inorganic Polymers (Geopolymers) as Potential Bioactive Materials.” 2009. Masters Thesis, Victoria University of Wellington. Accessed February 22, 2020. http://hdl.handle.net/10063/952.

MLA Handbook (7^th Edition):

Rahner, Nils. “Inorganic Polymers (Geopolymers) as Potential Bioactive Materials.” 2009. Web. 22 Feb 2020.

Vancouver:

Rahner N. Inorganic Polymers (Geopolymers) as Potential Bioactive Materials. [Internet] [Masters thesis]. Victoria University of Wellington; 2009. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/10063/952.

Council of Science Editors:

Rahner N. Inorganic Polymers (Geopolymers) as Potential Bioactive Materials. [Masters Thesis]. Victoria University of Wellington; 2009. Available from: http://hdl.handle.net/10063/952

University of Minnesota

24. Visweswaran, Ramjay. The importance of calcium cycling and mitochondria in the local onset of alternans in the heart.

Degree: PhD, Biomedical Engineering, 2014, University of Minnesota

URL: http://hdl.handle.net/11299/165107

► Action potential duration (APD) alternans can be accompanied by alternans in intracellular calcium, leading to electromechanical alternans. Electromechanical alternans is considered a substrate for ventricular… (more)

▼ Action potential duration (APD) alternans can be accompanied by alternans in intracellular calcium, leading to electromechanical alternans. Electromechanical alternans is considered a substrate for ventricular fibrillation, especially during pathophysiological conditions such as ischemia. The work in thesis seeks to elucidate the spatio-temporal evolution of alternans and to investigate the potential pathways through which they occur. High resolution mapping was used to simultaneously map membrane voltage and intracellular calcium in normal rabbit hearts. By mapping both parameters simultaneously in the same region of the heart, we were able to reveal that instability in calcium cycling plays a primary role in the development of EM alternans in the whole heart. Further, we were able to apply a special restitution portrait analysis to predict the onset of both calcium and APD alternans before it occurs. We also wanted to elucidate the mechanisms behind the increased incidences of arrhythmias during ischemia. By simulating ischemic and mitochondrial dysfunction in isolated rabbit hearts, we were able to show that mitochondrial stress caused by uncoupling of the mitochondria is responsible for early occurrence of both APD and calcium alternans in the heart, which in turn creates a substrate to ventricular arrhythmias. Thus, uncoupling of the mitochondrial network that occurs during ischemia might be the primary reason for increased incidences of arrhythmias in the heart during ischemia. Overall, this study improves our knowledge of alternans and their basic underlying mechanism which can be used in the development of better treatment and/or prevention strategies. Development of techniques to predict alternans before it occurs would be a valuable clinical tool, especially for use in implantable pacemakers paving the way for pre-emptive interventions. In addition, elucidating the mechanism or pathways of alternans formation would lead to targeted drug treatments to prevent alternans and thus, VF and sudden cardiac death.

Subjects/Keywords: Alternans; Calcium; Mitochondria

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APA (6^th Edition):

Visweswaran, R. (2014). The importance of calcium cycling and mitochondria in the local onset of alternans in the heart. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/165107

Chicago Manual of Style (16^th Edition):

Visweswaran, Ramjay. “The importance of calcium cycling and mitochondria in the local onset of alternans in the heart.” 2014. Doctoral Dissertation, University of Minnesota. Accessed February 22, 2020. http://hdl.handle.net/11299/165107.

MLA Handbook (7^th Edition):

Visweswaran, Ramjay. “The importance of calcium cycling and mitochondria in the local onset of alternans in the heart.” 2014. Web. 22 Feb 2020.

Vancouver:

Visweswaran R. The importance of calcium cycling and mitochondria in the local onset of alternans in the heart. [Internet] [Doctoral dissertation]. University of Minnesota; 2014. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/11299/165107.

Council of Science Editors:

Visweswaran R. The importance of calcium cycling and mitochondria in the local onset of alternans in the heart. [Doctoral Dissertation]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/165107

Penn State University

25. Du, Lei. Modulation of CaV1.2 Channel Activity: Role of Domain III.

Degree: MS, Physiology, 2009, Penn State University

URL: https://etda.libraries.psu.edu/catalog/9973

► Cardiac excitation-contraction coupling (ECC) is the fundamental cellular mechanism responsible for the continuous contraction of the heart. PLM, a small membrane protein of the FXYD… (more)

Subjects/Keywords: calcium channel; phospholemman

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APA (6^th Edition):

Du, L. (2009). Modulation of CaV1.2 Channel Activity: Role of Domain III. (Masters Thesis). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/9973

Chicago Manual of Style (16^th Edition):

Du, Lei. “Modulation of CaV1.2 Channel Activity: Role of Domain III.” 2009. Masters Thesis, Penn State University. Accessed February 22, 2020. https://etda.libraries.psu.edu/catalog/9973.

MLA Handbook (7^th Edition):

Du, Lei. “Modulation of CaV1.2 Channel Activity: Role of Domain III.” 2009. Web. 22 Feb 2020.

Vancouver:

Du L. Modulation of CaV1.2 Channel Activity: Role of Domain III. [Internet] [Masters thesis]. Penn State University; 2009. [cited 2020 Feb 22]. Available from: https://etda.libraries.psu.edu/catalog/9973.

Council of Science Editors:

Du L. Modulation of CaV1.2 Channel Activity: Role of Domain III. [Masters Thesis]. Penn State University; 2009. Available from: https://etda.libraries.psu.edu/catalog/9973

University of Manchester

26. Knight-Percival, Alexander Stephen. Low energy super-elastic scattering from laser excited calcium.

Degree: PhD, 2012, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/low-energy-superelastic-scattering-from-laser-excited-calcium(e37927e1-97d6-41eb-9a88-06109757c1a0).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558068

► Super-elastic scattering measurements were taken from calcium using the spectrometer described in this thesis. Calcium atoms were excited from the 41S0 ground state to the… (more)

▼ Super-elastic scattering measurements were taken from calcium using the spectrometer described in this thesis. Calcium atoms were excited from the 41S0 ground state to the 41P1 excited state using a high resolution continuous wave laser set to a wavelength of 423 nm. A beam of electrons with a well defined energy was directed at the laser excited calcium atoms. The excited state was then described by a set of atomic collision parameters P_lin, gamma and L_perp, found from measuring scattered electrons as a function of scattering angle and energy. The scattering chamber was held at a pressure of 3x10 -7 mbar. A resistively heated oven operating at 800 degrees celsius produced a well collimated calcium atomic beam containing the calcium atoms. The electron gun generated a beam of electrons of well defined momentum, whose energy could be changed from ~5 eV to over 100 eV. At energies less than 20 eV the rate of super-elastic electrons was very low, and so modifications were made to the spectrometer to automate data collection for long operating times without the need for user intervention. A new digitally controlled DC voltage supply was constructed to deliver the correct potentials to the electron-optical elements in the spectrometer. An internal microcontroller enabled supply voltages to be programmed either using the front panel or via an attached computer for automatic optimisation of spectrometer voltages using a simplex algorithm. New data was collected for the collision parameters over the full accessible angular range from 25 – 140 degrees, at energies of 8, 10 and 65 eV. The data at 8 and 10 eV was taken so as to resolve differences between theoretical models at low energies. Comparisons were made with a relativistic distorted wave calculation, an R-matrix calculation, an R-matrix calculation using B-splines and a convergent close coupling theory. A 2 eV discrepancy was identified in the measured electron energy which was thought to be due to stray fields in the chamber. With this considered, convergent close coupling predictions were found to be in excellent agreement with the experimental data.

Subjects/Keywords: 661; superelastic; calcium

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APA (6^th Edition):

Knight-Percival, A. S. (2012). Low energy super-elastic scattering from laser excited calcium. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/low-energy-superelastic-scattering-from-laser-excited-calcium(e37927e1-97d6-41eb-9a88-06109757c1a0).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558068

Chicago Manual of Style (16^th Edition):

Knight-Percival, Alexander Stephen. “Low energy super-elastic scattering from laser excited calcium.” 2012. Doctoral Dissertation, University of Manchester. Accessed February 22, 2020. https://www.research.manchester.ac.uk/portal/en/theses/low-energy-superelastic-scattering-from-laser-excited-calcium(e37927e1-97d6-41eb-9a88-06109757c1a0).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558068.

MLA Handbook (7^th Edition):

Knight-Percival, Alexander Stephen. “Low energy super-elastic scattering from laser excited calcium.” 2012. Web. 22 Feb 2020.

Vancouver:

Knight-Percival AS. Low energy super-elastic scattering from laser excited calcium. [Internet] [Doctoral dissertation]. University of Manchester; 2012. [cited 2020 Feb 22]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/low-energy-superelastic-scattering-from-laser-excited-calcium(e37927e1-97d6-41eb-9a88-06109757c1a0).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558068.

Council of Science Editors:

Knight-Percival AS. Low energy super-elastic scattering from laser excited calcium. [Doctoral Dissertation]. University of Manchester; 2012. Available from: https://www.research.manchester.ac.uk/portal/en/theses/low-energy-superelastic-scattering-from-laser-excited-calcium(e37927e1-97d6-41eb-9a88-06109757c1a0).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558068

27. Hamoudi, Amine. Réaction alcali-silice dans le béton : étude de la dégradation structurale comparée de composés SiO2 (silice amorphe, quartz, silex) : Alkali silica reaction in the concrete : study of the compared structural degradation of SiO2 compounds (silica glass, quartz, flint).

Degree: Docteur es, Molécules et matière condensée, 2009, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2009LIL10113

►

Les liens qui unissent la structure et les propriétés physiques, chimiques des matériaux sont très importants. En particulier, le degré d’ordre, les défauts cristallins, l’hétérogénéité… (more)

▼

Les liens qui unissent la structure et les propriétés physiques, chimiques des matériaux sont très importants. En particulier, le degré d’ordre, les défauts cristallins, l’hétérogénéité structurale ou chimique, s’avèrent être des paramètres très pertinents dans la réactivité des matériaux. Ce travail a porté sur l’étude de la réactivité de plusieurs formes de la silice, et permet de montrer l’influence de l’ordre et de la cristallinité sur les processus de vieillissement par la réaction alcali-silice. Dans cette objectif, la réactivité de trois matériaux différents : granulats (silex), quartz et verre de silice a été suivie par différentes techniques d’investigations.Le quartz réagit très lentement, le verre très vite et le granulat de manière intermédiaire. Une analyse plus fine montre que la fraction mal cristallisée, voire amorphe, du granulat réagit préférentiellement.Le caractère désordonné des matériaux suggère l’utilisation de techniques sensibles à l’ordre local : nous avons employé, la spectroscopie d’absorption X (XANES et EXAFS) complétée par la RMN du solide.Les cartographies chimiques obtenues par microscopie électronique (en balayage et en transmission) ou au synchrotron montrent que le potassium K+ diffuse le premier et que le calcium Ca++ pénètre difficilement la structure cristalline de la silice. A l’échelle locale la RMN du silicium montre la dépolymérisation du réseau permet la diffusion des cations Ca++.Le micro-XANES révèle la présence de plusieurs environnements autour des atomes de silicium. L’un consiste en un silicium avec quatre oxygènes premiers voisins et l’autre avec moins de quatre atomes d’oxygènes. D’autre part, l’EXAFS montre l’absence du Ca et/ou K au niveau de la deuxième couche de voisins de l’atome de silicium absorbeur dans un environnement ordonné.

The relationships between the structure and the physical and chemical properties are very important in materials. In particular, the degree of order, the crystal defects and the structural heterogeneities or chemical parameters appear to play a key role in the reactivity of materials. This work is devoted to the study of the reactivity of silica-based materials, and shows of the influence of ordering and crystallinity on the sensitivity to the alkali silica reaction. In this perspective, the reactivity of three different materials: silica glass, aggregates (Flint) and quartz was followed by various techniques. Quartz reacts very slowly whereas the silica glass reacts very quickly, the aggregate exhibiting an intermediate behavior. A closer analysis shows that the amorphous or poorly crystalline fraction of the aggregate reacts preferentially. The role played by these poorly crystalline fractions suggests the use of techniques sensitive to short and medium range order such as: X-ray absorption spectroscopy (XANES and EXAFS) and solid state NMR. Chemical maps obtained by electron microscopy (scanning or in transmission) or at the synchrotron, show that the potassium K+ is the first to diffuse and that penetration of calcium Ca++ is…

Advisors/Committee Members: Khouchaf, Lahcen (thesis director), Cordier, Patrick (thesis director).

Subjects/Keywords: Silicates de calcium

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APA (6^th Edition):

Hamoudi, A. (2009). Réaction alcali-silice dans le béton : étude de la dégradation structurale comparée de composés SiO2 (silice amorphe, quartz, silex) : Alkali silica reaction in the concrete : study of the compared structural degradation of SiO2 compounds (silica glass, quartz, flint). (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2009LIL10113

Chicago Manual of Style (16^th Edition):

Hamoudi, Amine. “Réaction alcali-silice dans le béton : étude de la dégradation structurale comparée de composés SiO2 (silice amorphe, quartz, silex) : Alkali silica reaction in the concrete : study of the compared structural degradation of SiO2 compounds (silica glass, quartz, flint).” 2009. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed February 22, 2020. http://www.theses.fr/2009LIL10113.

MLA Handbook (7^th Edition):

Hamoudi, Amine. “Réaction alcali-silice dans le béton : étude de la dégradation structurale comparée de composés SiO2 (silice amorphe, quartz, silex) : Alkali silica reaction in the concrete : study of the compared structural degradation of SiO2 compounds (silica glass, quartz, flint).” 2009. Web. 22 Feb 2020.

Vancouver:

Hamoudi A. Réaction alcali-silice dans le béton : étude de la dégradation structurale comparée de composés SiO2 (silice amorphe, quartz, silex) : Alkali silica reaction in the concrete : study of the compared structural degradation of SiO2 compounds (silica glass, quartz, flint). [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2009. [cited 2020 Feb 22]. Available from: http://www.theses.fr/2009LIL10113.

Council of Science Editors:

Hamoudi A. Réaction alcali-silice dans le béton : étude de la dégradation structurale comparée de composés SiO2 (silice amorphe, quartz, silex) : Alkali silica reaction in the concrete : study of the compared structural degradation of SiO2 compounds (silica glass, quartz, flint). [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2009. Available from: http://www.theses.fr/2009LIL10113

University of Aberdeen

28. Thammakan, Nirawan. Synthesis and characterisation of calcium phosphate compositions by precipitation and 'biomimetic methods'.

Degree: PhD, 2016, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230656 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.694692

► Calcium phosphate compounds have been widely utilised in the interdisciplinary field of biomaterials research and are used clinically in a number of medical devices. In… (more)

▼ Calcium phosphate compounds have been widely utilised in the interdisciplinary field of biomaterials research and are used clinically in a number of medical devices. In the present work, calcium phosphate compositions were prepared by two precipitation methods: a classic aqueous precipitation method and a novel biomimetic precipitation method. The aqueous precipitation method was used to produce a range of hydroxyapatite and carbonate-substituted hydroxyapatite compositions that would act as reference materials, but more importantly to allow a method of determining the Ca/P molar ratio of these compositions using X-ray diffraction data. The importance of this was that a simple technique would be required for studying the calcium phosphates produced later by biomimetic methods, as the very low yields prevents traditional methods such as XRF. It was found that Rietveld refinement of XRD data from precipitated apatites that had been heated at between 800 and 1200°C in air provided quantitative phase compositions that could then be used to calculate Ca/P molar ratios. In order to use synthesis conditions that were more similar to in vivo mineralisation, calcium phosphate compositions were directly prepared by using alkali-induced 'biomimetic' precipitation from Simulated Body Fluid (SBF) under controlled conditions. The key parameters that were studied were the effect of precipitation pH, the SBF concentration, the reaction time, the soaking time, and the magnesium and the carbonate ion concentration of the SBF solution. The key finding was that while the precipitated product obtained from 'conventional' SBF was an amorphous calcium phosphate with a Ca/P molar ratio of 1.5, irrespective of the pH, SBF concentration, reaction time or carbonate ion concentration, the gradual removal of magnesium ions from the SBF solution led to the precipitation of firstly a Ca-deficient apatite and eventually (for low Mg concentrations and a Mg-free SBF) a stoichiometric hydroxyapatite with a Ca/P molar ratio of 1.67. This method resulted in very low yields, typically (50 mg from 100 ml of SBF) but control of parameters could yield different phase compositions and could also affect the crystal size and the crystallinity of the product. These observations highlighting the important role of magnesium ions in the SBF on the composition of the calcium phosphate phase that would precipitate raised the question of what effect does SBF magnesium ion content have on the surface apatite precipitation on various biomaterials when incubated in SBF, which is the classic in vitro bioactivity test. Studies that incubated bioactive glass discs and powder (45S5 composition) and dense hydroxyapatite ceramic discs in conventional SBF and an Mg-free SBF showed that the rate of surface apatite precipitation was significantly affected by the Mg content in the SBF. For the case of bioactive glass discs, a surface apatite layer formed in 2 hours when incubated in an Mg-free SBF compared to 24 hours in conventional SBF.

Subjects/Keywords: 610.28; Calcium phosphate

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thammakan, N. (2016). Synthesis and characterisation of calcium phosphate compositions by precipitation and 'biomimetic methods'. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230656 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.694692

Chicago Manual of Style (16^th Edition):

Thammakan, Nirawan. “Synthesis and characterisation of calcium phosphate compositions by precipitation and 'biomimetic methods'.” 2016. Doctoral Dissertation, University of Aberdeen. Accessed February 22, 2020. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230656 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.694692.

MLA Handbook (7^th Edition):

Thammakan, Nirawan. “Synthesis and characterisation of calcium phosphate compositions by precipitation and 'biomimetic methods'.” 2016. Web. 22 Feb 2020.

Vancouver:

Thammakan N. Synthesis and characterisation of calcium phosphate compositions by precipitation and 'biomimetic methods'. [Internet] [Doctoral dissertation]. University of Aberdeen; 2016. [cited 2020 Feb 22]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230656 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.694692.

Council of Science Editors:

Thammakan N. Synthesis and characterisation of calcium phosphate compositions by precipitation and 'biomimetic methods'. [Doctoral Dissertation]. University of Aberdeen; 2016. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230656 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.694692

Boston University

29. McLoed, Melissa. THE mitochondrial uniporter modulates neuronal regenerative outgrowth and calcium dynamics following axotomy in C. elegans.

Degree: 2015, Boston University

URL: http://hdl.handle.net/2144/13983

► Following neuronal injury, calcium signaling plays a critical role in promoting repair processes. Injury produces an initial cytosolic calcium elevation mediated by calcium entry from… (more)

Subjects/Keywords: Neurosciences; Calcium; Mitochondria

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McLoed, M. (2015). THE mitochondrial uniporter modulates neuronal regenerative outgrowth and calcium dynamics following axotomy in C. elegans. (Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/13983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McLoed, Melissa. “THE mitochondrial uniporter modulates neuronal regenerative outgrowth and calcium dynamics following axotomy in C. elegans.” 2015. Thesis, Boston University. Accessed February 22, 2020. http://hdl.handle.net/2144/13983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McLoed, Melissa. “THE mitochondrial uniporter modulates neuronal regenerative outgrowth and calcium dynamics following axotomy in C. elegans.” 2015. Web. 22 Feb 2020.

Vancouver:

McLoed M. THE mitochondrial uniporter modulates neuronal regenerative outgrowth and calcium dynamics following axotomy in C. elegans. [Internet] [Thesis]. Boston University; 2015. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/2144/13983.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McLoed M. THE mitochondrial uniporter modulates neuronal regenerative outgrowth and calcium dynamics following axotomy in C. elegans. [Thesis]. Boston University; 2015. Available from: http://hdl.handle.net/2144/13983

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

30. Macha, Innocent. Calcium phosphate and bioglass reinforced PLA thin film biocomposites for slow drug delivery applications .

Degree: 2016, University of Dar es Salaam

URL: http://hdl.handle.net/20.500.11810/2636

► The rise in the number of musculoskeletal disorders (MSDs) due to the increase in aging population and advancement in medical technology has led to an… (more)

▼ The rise in the number of musculoskeletal disorders (MSDs) due to the increase in aging population and advancement in medical technology has led to an increasing demand for medication to prevent and treat these diseases. The development of new drugs or formulations to allow treatment of these diseases in their very early stages is only increasing. Local direct and multidelivery of medication and key minerals to support bone repair and regeneration at the defect site, from flexible degradable devices at the rate within the therapeutic window, seems to be an effective strategy. However current drug delivery vehicles are neither flexible and degradable, nor able to deliver both medication and minerals effectively. Using a simple “solution casting” method, preparation of medical devices with such potential for slow drug delivery for biomedical applications served as the research objective. Polylactic acid (PLA) and hydroxyapatite-hydrothermally converted coral were used to develop PLA thin film composites as drug delivery systems. PLA provided flexibility and biodegradability of the systems, while coralline hydroxyapatite provided a unique architecture with its porous and bioactive nature, which is suitable for drug loading and slow drug release. Two drugs, gentamicin (antibiotic) and bisphosphonate were loaded into the device and their release profiles and activities were studied for the treatment of medical-implant related infection and osteoposis respectively. The biocompatibility study on human adipose derived stem cells (hADSC) and biofilm formation behaviour of both gram-negative (Pseudomonas aeruginosa) and gram-positive bacterial (Staphylococcus aureus) were studied on PLA thin film composites loaded with gentamicin. The mechanical properties of PLA-surface treated bioglass for tissue engineering applications was also studied. An alternative conversion method of coralline materials and other natural materials such as sea mussel and ostrich eggshells to calcium phosphate materials were also evaluated. Although nanosurface bioglass treated with 1% (3-Aminopropyl) triethoxysilane (APTES) suggested effective improvement in elongation at the break of PLA/bioglass composites, they lacked the required drug release efficiency. However, the PLA thin film composites displayed ability for potential applications in biomedical field as drug delivery systems. The flexibility they provide allows them to conform to any desired clinical shape and size. Incorporation of hydroxyapatite in the matrix, has the added advantages of controlled release, improved encapsulation efficiency, increased drug stability and maintenance of bioactivity and continuous supply of calcium Ca²⁺ and phosphate PO₄²⁻ ions, which can assist in bone regeneration and repair. Gentamicin release profiles, exhibited a steady state release rate, with significant antimicrobial activity even at high concentrations of bacteria. The systems also showed the potential for prolonged release of both antibiotic and bisphosphonate. The loading of the drug onto HAp…

Subjects/Keywords: Calcium phosphate; drugs

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Macha, I. (2016). Calcium phosphate and bioglass reinforced PLA thin film biocomposites for slow drug delivery applications . (Doctoral Dissertation). University of Dar es Salaam. Retrieved from http://hdl.handle.net/20.500.11810/2636

Chicago Manual of Style (16^th Edition):

Macha, Innocent. “Calcium phosphate and bioglass reinforced PLA thin film biocomposites for slow drug delivery applications .” 2016. Doctoral Dissertation, University of Dar es Salaam. Accessed February 22, 2020. http://hdl.handle.net/20.500.11810/2636.

MLA Handbook (7^th Edition):

Macha, Innocent. “Calcium phosphate and bioglass reinforced PLA thin film biocomposites for slow drug delivery applications .” 2016. Web. 22 Feb 2020.

Vancouver:

Macha I. Calcium phosphate and bioglass reinforced PLA thin film biocomposites for slow drug delivery applications . [Internet] [Doctoral dissertation]. University of Dar es Salaam; 2016. [cited 2020 Feb 22]. Available from: http://hdl.handle.net/20.500.11810/2636.

Council of Science Editors:

Macha I. Calcium phosphate and bioglass reinforced PLA thin film biocomposites for slow drug delivery applications . [Doctoral Dissertation]. University of Dar es Salaam; 2016. Available from: http://hdl.handle.net/20.500.11810/2636

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Open Access Theses and Dissertations