subject:(Calcium channel blocker)

University of Adelaide

1. Ball, Christine June. Calcium channel distribution in the arterial vascular tree and its relation to function.

Degree: 2010, University of Adelaide

► Clinical evidence in microvascular disease suggests that T-type Ca⁺⁺ channel blockers (CCBs) have benefits over conventional L-type CCBs, however the basis for this remains largely… (more)

▼ Clinical evidence in microvascular disease suggests that T-type Ca⁺⁺ channel blockers (CCBs) have benefits over conventional L-type CCBs, however the basis for this remains largely unknown. The objective of this study was to examine vascular reactivity utilising both pharmacological and molecular techniques. This thesis is composed of three sections including (A) an Introduction, (B) Functional Vascular Studies and (C) Molecular Vascular Studies. Section A summarised fundamental principles of the vasculature including an outline of the vascular system, vascular physiology, vascular cell biology, regulation of cytosolic Ca⁺⁺ and vascular pathophysiology. Section B utilised isolated vessels and wire myography to determine the effect of pre-treatment with L-type CCBs (verapamil and nifedipine) and combined L- and T-type CCBs (mibefradil and efonidipine) on endothelin-1 (Et-1) and K⁺-mediated contractile responses in large (rat aorta) and small (rat mesenteric and human subcutaneous) vessels. All four CCBs inhibited both Et-1 and K⁺-mediated contractile responses to a similar extent in large rat vessels, however in rat microvessels the combined L- and T-channel blockers produced significantly greater inhibition of contraction than L-channel blockers alone. The significance of this differential T-channel effect in microvessels was further supported by: (1) demonstration of divergent CCB responses in human microvessels, (2) incremental inhibition of constrictor responses with a combined L- and T-CCB despite maximal L-channel blockade, (3) utilisation of structurally diverse CCBs with varied affinity for L- and T-channels, (6) use of pharmacodynamically and therapeutically appropriate CCB concentrations, (7) confirmation of contractile agonist independent responses, (8) consistent results even in the presence of an altered microvascular physiology in the form of chronic Et-1 activation and (9) exclusion of an endothelium-dependent mechanism. Section C utilised the molecular techniques of quantitative polymerase chain reaction (PCR) and ratiometric western blotting to examine the distribution of the pore-forming subunits Caᵥ1.2, Caᵥ3.1 and 3.2 in both large (rat aorta) and small (rat mesenteric) vessels. The PCR data was equivocal with no difference noted in the distribution of the L- and T-channels between large and small vessels. In contrast to this, quantitative western blot analysis revealed that while there is a similar distribution of the three subunits in the large vessel, there is a significantly increased expression of both T-channel pore-forming subunits in microvessels (Caᵥ3.1: 112 ± 38%*, Caᵥ3.2: 168 ± 48%* relative to L-channel expression, *p<0.05). Considered together these ‘functional’ and ‘structural’ studies indicate the important role of the Ca⁺⁺ T-channel in regulating contractile responses in the microvasculature and their therapeutic potential. Advisors/Committee Members: Beltrame, John Francis (advisor), Saint, David Albert (advisor), Wilson, David Peter Murray (advisor), School of Medicine (school).

Subjects/Keywords: calcium; vasculature; microvasculature; calcium channel blocker

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ball, C. J. (2010). Calcium channel distribution in the arterial vascular tree and its relation to function. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/63325

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ball, Christine June. “Calcium channel distribution in the arterial vascular tree and its relation to function.” 2010. Thesis, University of Adelaide. Accessed February 28, 2021. http://hdl.handle.net/2440/63325.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ball, Christine June. “Calcium channel distribution in the arterial vascular tree and its relation to function.” 2010. Web. 28 Feb 2021.

Vancouver:

Ball CJ. Calcium channel distribution in the arterial vascular tree and its relation to function. [Internet] [Thesis]. University of Adelaide; 2010. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2440/63325.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ball CJ. Calcium channel distribution in the arterial vascular tree and its relation to function. [Thesis]. University of Adelaide; 2010. Available from: http://hdl.handle.net/2440/63325

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Sharma, Arun. Comparative study of efficacy and tolerability of angiotensin-ii receptor antagonist (Losartan Potassium) with ACE inhibitor (Enalapril), Beta blocker (Atenolol), Calcium Channel blocker (Amlodipine), Alpha blocker (Terazosin), in systemic hypertension and its complications; -.

Degree: Medicine, 2000, Bundelkhand University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/11124

None

Bibliography p. 78-84

Advisors/Committee Members: Arora, R C, Arora, Sunita.

Subjects/Keywords: Medicine; Beta Blocker; Calcium Channel Blocker; Alpha Blocker; Hypertension

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sharma, A. (2000). Comparative study of efficacy and tolerability of angiotensin-ii receptor antagonist (Losartan Potassium) with ACE inhibitor (Enalapril), Beta blocker (Atenolol), Calcium Channel blocker (Amlodipine), Alpha blocker (Terazosin), in systemic hypertension and its complications; -. (Thesis). Bundelkhand University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/11124

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sharma, Arun. “Comparative study of efficacy and tolerability of angiotensin-ii receptor antagonist (Losartan Potassium) with ACE inhibitor (Enalapril), Beta blocker (Atenolol), Calcium Channel blocker (Amlodipine), Alpha blocker (Terazosin), in systemic hypertension and its complications; -.” 2000. Thesis, Bundelkhand University. Accessed February 28, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/11124.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sharma, Arun. “Comparative study of efficacy and tolerability of angiotensin-ii receptor antagonist (Losartan Potassium) with ACE inhibitor (Enalapril), Beta blocker (Atenolol), Calcium Channel blocker (Amlodipine), Alpha blocker (Terazosin), in systemic hypertension and its complications; -.” 2000. Web. 28 Feb 2021.

Vancouver:

Sharma A. Comparative study of efficacy and tolerability of angiotensin-ii receptor antagonist (Losartan Potassium) with ACE inhibitor (Enalapril), Beta blocker (Atenolol), Calcium Channel blocker (Amlodipine), Alpha blocker (Terazosin), in systemic hypertension and its complications; -. [Internet] [Thesis]. Bundelkhand University; 2000. [cited 2021 Feb 28]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11124.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sharma A. Comparative study of efficacy and tolerability of angiotensin-ii receptor antagonist (Losartan Potassium) with ACE inhibitor (Enalapril), Beta blocker (Atenolol), Calcium Channel blocker (Amlodipine), Alpha blocker (Terazosin), in systemic hypertension and its complications; -. [Thesis]. Bundelkhand University; 2000. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11124

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Federal de Santa Maria

3. Luiz Augusto Wentz. AUMENTO GENGIVAL ASSOCIADO À CICLOSPORINA EM TRANSPLANTADOS RENAIS NO HUSM.

Degree: 2010, Universidade Federal de Santa Maria

URL: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=3076

►

Background: Gingival enlargement (GE) is a frequent finding in cyclosporin users. The mechanisms of this association are not totally known and point out to a… (more)

▼

Background: Gingival enlargement (GE) is a frequent finding in cyclosporin users. The mechanisms of this association are not totally known and point out to a multifactorial model, with dose and associations with calcium channel blockers. Novel immunosuppression protocols are adjusting for drugs and dosages. Aim: This study aimed at investigating the prevalence and severity of gingival enlargement in renal transplanted individuals under cyclosporin and possible associations with clinical and pharmacological findings. Methods: With a cross- sectional design, 63 renal transplanted patients under cyclosporin therapy from the University Hospital of the Santa Maria Federal University were examined. Demographic, pharmacological and periodontal variables were assessed. Data analysis, independent sample t test and chi square were used to compare means values of different variables, comparing groups with or without gingival enlargement. Results: A response rate of 86,30% was achieved. In total, 40% of the patients presented some degree of GE. Eleven presented scores >10% and only 5 presented scores of 30%. Mean value for GE was low (6,7915,83). Patients under nifedipine presented higher prevalence of GE, without reaching statistical significance. Mean values for serum levels of CsA were 3,200,94 mg/kg/day and 156,12162,75 ng/ml, respectively. No statistically significant differences among individuals with or without GE was obtained relating to the use of nifedipine and/or none/verapamil. Conclusion: A lower prevalence and severity of GE was found in relation to previous studies, independent to the drug association.

Justificativa: Aumento gengival (AG) é um achado freqüente em pacientes que utilizam Ciclosporina (CsA). Os mecanismos dessa associação não são totalmente conhecidos e apontam para um modelo multifatorial, com doses e associações com outras drogas, como bloqueadores de canais de cálcio (BCC). Novos protocolos de imunossupressão vêm ajustando fármacos e doses visando obter melhores resultados na terapia, diminuindo também os efeitos adversos. Objetivo: Este estudo tem por objetivo investigar a prevalência e a gravidade de aumento gengival em transplantados renais medicados com CsA, e possíveis associações com fatores farmacológicos e clínicos. Metodologia: Utilizando um delineamento transversal, foram examinados 63 transplantados renais em terapia com CsA no Hospital Universitário de Santa Maria (HUSM). Dados demográficos, farmacológicos e periodontais foram coletados. Para a análise dos dados, foram utilizados o teste t não-pareado e qui-quadrado a fim de comparar as médias das variáveis para os grupos com e sem aumento gengival. Resultados: Uma taxa de resposta de 86,3% foi obtida. Ao todo 40% dos pacientes apresentaram algum grau de AG. Onze apresentaram escores acima de 10% e apenas 5 com 30%. A média de AG foi baixa (6,79). Pacientes que utilizam nifedipina apresentaram maior prevalência de AG, sem significância estatística. As médias de dosagem e níveis séricos de CsA foram 3,20 mg/kg/dia e 156,12 ng/ml,…

Advisors/Committee Members: Cassiano Kuchenbecker Rosing, Marilene Issa Fernandes, Thiago Machado Ardenghi, Carlos Heitor Cunha Moreira.

Subjects/Keywords: Aumento gengival; ODONTOLOGIA; Gingival enlargement; cyclosporin; calcium channel blocker; bloqueador de canal de cálcio; ciclosporina

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wentz, L. A. (2010). AUMENTO GENGIVAL ASSOCIADO À CICLOSPORINA EM TRANSPLANTADOS RENAIS NO HUSM. (Thesis). Universidade Federal de Santa Maria. Retrieved from http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=3076

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wentz, Luiz Augusto. “AUMENTO GENGIVAL ASSOCIADO À CICLOSPORINA EM TRANSPLANTADOS RENAIS NO HUSM.” 2010. Thesis, Universidade Federal de Santa Maria. Accessed February 28, 2021. http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=3076.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wentz, Luiz Augusto. “AUMENTO GENGIVAL ASSOCIADO À CICLOSPORINA EM TRANSPLANTADOS RENAIS NO HUSM.” 2010. Web. 28 Feb 2021.

Vancouver:

Wentz LA. AUMENTO GENGIVAL ASSOCIADO À CICLOSPORINA EM TRANSPLANTADOS RENAIS NO HUSM. [Internet] [Thesis]. Universidade Federal de Santa Maria; 2010. [cited 2021 Feb 28]. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=3076.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wentz LA. AUMENTO GENGIVAL ASSOCIADO À CICLOSPORINA EM TRANSPLANTADOS RENAIS NO HUSM. [Thesis]. Universidade Federal de Santa Maria; 2010. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=3076

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arizona

4. Goodlow, Tranise Hamilton. Provider Adherence to JNC 8 Pharmacological Guideline Recommendations in African American Adults Diagnosed with Hypertension .

Degree: 2017, University of Arizona

URL: http://hdl.handle.net/10150/626646

► Background: In the United States, one-third of adults have hypertension (HTN). Among African American (AA) adults, 43% of men and 45.7% of women have HTN.… (more)

▼ Background: In the United States, one-third of adults have hypertension (HTN). Among African American (AA) adults, 43% of men and 45.7% of women have HTN. HTN in the AA adult population is more severe and occurs earlier in life compared to Caucasian adults, putting them at increased risk for cardiovascular events and renal disease. The Eighth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 8) Guideline Recommendations 7 and 8 were developed to aid in appropriate treatment and management of hypertensive AA adults. Purpose: The purpose of this Doctor of Nursing Practice (DNP) project was to improve the care, management, and outcomes of hypertensive AA adults by identifying current JNC 8 guideline prescribing patterns among a sample of hospitalized patients. The first project aim was to determine provider-prescribing rates of thiazide diuretics (TDs) and calcium channel blockers (CCBs) in newly diagnosed AA adults with HTN. The second project aim was to determine if AA adults previously diagnosed with HTN were currently prescribed TD and/or CCB medications. Methods: A retrospective medical record review of AA adult patients with a new HTN diagnosis or previously diagnosed with HTN was selected for this project. Participants were discharged from Medical City Dallas between 01/01/2017 and 03/31/2017. Results: In newly diagnosed participants with HTN, none were prescribed a TD (0%) and two were prescribed a CCB (40%). In previously diagnosed participants with HTN, 30 participants (16.3%) were prescribed a TD and/or CCB upon admission and 29 participants (15.76%) were prescribed a TD and/or CCB upon discharge. Among prescribing providers, beta blockers and other class hypertensive medications (i.e., furosemide, hydralazine, clonidine, and spironolactone) were most widely ordered for participants. Conclusions: The results of this DNP project display low provider compliance rates to guideline-recommended pharmacological therapy AA adults. This outcome highlights several potential reasons for the low adherence rates, including lack of provider documentation, lack of provider rationale for treatment selections, provider knowledge of HTN CPGs, and data analysis of prescribed medications. These factors present the opportunity for further research to identify the root cause of low compliance. Advisors/Committee Members: Buchner, Brian R (advisor), Buchner, Brian R. (committeemember), Gephart, Sheila M. (committeemember), Szalacha, Laura (committeemember).

Subjects/Keywords: African Americans; Calcium Channel Blocker; High Blood Pressure; Hypertension; JNC 8 Guidelines; Thiazide Diuretic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Goodlow, T. H. (2017). Provider Adherence to JNC 8 Pharmacological Guideline Recommendations in African American Adults Diagnosed with Hypertension . (Doctoral Dissertation). University of Arizona. Retrieved from http://hdl.handle.net/10150/626646

Chicago Manual of Style (16^th Edition):

Goodlow, Tranise Hamilton. “Provider Adherence to JNC 8 Pharmacological Guideline Recommendations in African American Adults Diagnosed with Hypertension .” 2017. Doctoral Dissertation, University of Arizona. Accessed February 28, 2021. http://hdl.handle.net/10150/626646.

MLA Handbook (7^th Edition):

Goodlow, Tranise Hamilton. “Provider Adherence to JNC 8 Pharmacological Guideline Recommendations in African American Adults Diagnosed with Hypertension .” 2017. Web. 28 Feb 2021.

Vancouver:

Goodlow TH. Provider Adherence to JNC 8 Pharmacological Guideline Recommendations in African American Adults Diagnosed with Hypertension . [Internet] [Doctoral dissertation]. University of Arizona; 2017. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10150/626646.

Council of Science Editors:

Goodlow TH. Provider Adherence to JNC 8 Pharmacological Guideline Recommendations in African American Adults Diagnosed with Hypertension . [Doctoral Dissertation]. University of Arizona; 2017. Available from: http://hdl.handle.net/10150/626646

NSYSU

5. Yang, Ching-ping. The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease.

Degree: Master, Institute of Health Care Management, 2009, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0617109-120417

► Research Objective Patients with chronic kidney disease (CKD) are at increased risk for atherosclerosis and peripheral artery disease (PAD). PAD has received far less attention… (more)

▼ Research Objective Patients with chronic kidney disease (CKD) are at increased risk for atherosclerosis and peripheral artery disease (PAD). PAD has received far less attention than coronary artery disease (CAD) in CKD patients. Few studies have examined risk factors for PAD in CKD. We studied the possible related risk factors and benefit of hypertension treatment in CKD patients with PAD. Data Sources We included 129 patients of both sexes with stages 3 to 5 of CKD, as described by the Kidney Outcome Quality Initiatives (K/DOQI ) classification, without receiving dialysis therapy, not previously diagnosed with PAD. Study Design The following information were collected within six month period, including demographic characteristics, history of hypertension, anti-hypertension drug, diabetes, smoking, and pre-existing cardiovascular disease, body mass index (BMI), fasting blood glucose, HbA1c, total cholesterol, triglyceride(TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol(LDL), calcium (Ca), phosphate(P), Albumin, uric acid, urine protein. Ankle-brachial index (ABI) is a noninvasive diagnostic test that is efficient in detecting asymptomatic PAD with ABI <0.9. Findings There were 22 (17.7 %) participants with PAD. Higher systolic blood pressure (SBP), higher diastolic blood pressure (DBP), higher pulse pressure showed strong association with PAD in CKD patients. On further analysis, significant fewer patients treated with calcium channel blocker (CCB) in hypertensive CKD patients with PAD (Ï2 =7.055, p =0.008). The multivariate logistic regression analysis in hypertensive patients demonstrated the risk factors for PAD was pulse pressure, and Calcium channel blocker treatment may correlate with decreasing PAD formation (odds ratio= 0.232, 95% CI=0.07-0.73, p =0.013) in CKD patients. Conclusion There is a high prevalence rate of PAD in population of CKD, especially those with hypertension. ABI should be routinely examined in these patients who can benefit earlier from therapeutic measures. Advisors/Committee Members: Ying-chun Li (chair), Shu-chuan Jennifer Yeh (committee member), Meng-chiao Lin (chair).

Subjects/Keywords: Ankle brachial index; Chronic kidney disease; Calcium channel blocker; Pulse pressure; hypertension; Peripheral artery disease

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APA (6^th Edition):

Yang, C. (2009). The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0617109-120417

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yang, Ching-ping. “The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease.” 2009. Thesis, NSYSU. Accessed February 28, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0617109-120417.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yang, Ching-ping. “The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease.” 2009. Web. 28 Feb 2021.

Vancouver:

Yang C. The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease. [Internet] [Thesis]. NSYSU; 2009. [cited 2021 Feb 28]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0617109-120417.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yang C. The Prevalence and Clinical Correlative Factors of Peripheral Arterial Disease in Patients with Chronic Kidney Disease. [Thesis]. NSYSU; 2009. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0617109-120417

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Sikkander, A Mohamed. Electroanalysis of organic drugs;.

Degree: Chemistry, 2011, Periyar University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/8216

None

References p. 226-234, List of publications p. 235-

Advisors/Committee Members: Manisankar P.

Subjects/Keywords: Chemistry; Organic drugs; Channel Blocker Drugs; Glassy Carbon Electrode; Calcium Channel Blocker

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APA (6^th Edition):

Sikkander, A. M. (2011). Electroanalysis of organic drugs;. (Thesis). Periyar University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/8216

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sikkander, A Mohamed. “Electroanalysis of organic drugs;.” 2011. Thesis, Periyar University. Accessed February 28, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/8216.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sikkander, A Mohamed. “Electroanalysis of organic drugs;.” 2011. Web. 28 Feb 2021.

Vancouver:

Sikkander AM. Electroanalysis of organic drugs;. [Internet] [Thesis]. Periyar University; 2011. [cited 2021 Feb 28]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/8216.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sikkander AM. Electroanalysis of organic drugs;. [Thesis]. Periyar University; 2011. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/8216

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Thyago Moreira de Queiroz. Avaliação da atividade vasorrelaxante da alga marinha brasileira Dictyota pulchella Hörning &Schnetter em ratos normotensos.

Degree: 2011, Universidade Federal da Paraíba

URL: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1780

►

Os efeitos farmacológicos do extrato CH2Cl2:MeOH (EDP) e fase Hexano:AcOEt (FDP) da alga marinha brasileira Dictyota pulchella foram estudados sobre o sistema cardiovascular de ratos,… (more)

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Os efeitos farmacológicos do extrato CH2Cl2:MeOH (EDP) e fase Hexano:AcOEt (FDP) da alga marinha brasileira Dictyota pulchella foram estudados sobre o sistema cardiovascular de ratos, utilizando uma abordagem in vivo e in vitro. Em ratos normotensos não anestesiados, EDP (5; 10; 20 e 40 mg/kg, i.v., randomicamente) promoveu hipotensão (-4,1 1,34; -7,0 2,4; -46,9 1,3 e -54,8 4,3%, respectivamente) acompanhada de bradicardia (-2,1 1,6; -4,0 2,3; -66,8 5,2 e - 74,7 4,5%, respectivamente) (n=5). Em anéis de artéria mesentérica superior isolada de rato pré-contraídos com Fenilefrina (FEN) 1 μM, EDP (0,01 500 μg/mL) promoveu um efeito vasorrelaxante dependente de concentração na presença do endotélio vascular (Emáx = 101,4 4,5%; CE50 = 22,35 5,09 μg/mL), e este efeito não foi alterado após a remoção do endotélio (Emáx = 103,3 8,3%; CE50 = 21,43 8,98 μg/mL) (n=7). Resultados semelhantes foram obtidos na presença de FDP (0,01 500 μg/mL), observando-se um vasorrelaxamento tanto na presença (Emáx = 80,6 5,8%; CE50 = 24,1 8,9 μg/mL), quanto na ausência do endotélio funcional (Emáx = 95,6 7,5%; CE50 = 23,70 5,65 mg/mL). Para avaliar se o efeito de EDP era dependente do tônus vascular, este extrato foi testado no tônus basal, na presença ou ausência do endotélio, demonstrando que a resposta não foi alterada em nenhuma das duas situações. Baseado nos resultados preliminares, os experimentos subseqüentes foram realizados com endotélio desnudo. Para avaliar a participação dos canais para potássio (K+), utilizou-se uma solução com 20 mM de KCl ou tetraetilâmonio (TEA) 3 mM. Em ambas as preparações (Emáx = 102,3 4,8%; CE50 = 25,40 6,05 μg/mL) ou (Emáx = 111,2 5,3%; CE50 = 16,70 3,61 μg/mL) (n=7), respectivamente, a atividade vasorrelaxante de EDP não foi alterada. Na presença de outro agente contracturante, U46619 (100 nM), EDP promoveu um efeito vasorrelaxante (Emáx = 90,3 7,8%; CE50 = 24,63 4,04 μg/mL) de maneira similar aos anéis pré-contraídos com FEN. Em experimentos contendo uma solução despolarizante de 60 mM de KCl, EDP causou vasorrelaxamento dependente de concentração (Emáx = 97,7 4,0%; CE50 = 34,57 5,11 mg/mL; n=6). Na mesma condição experimental, FDP também promoveu um efeito vasorrelaxante (Emáx = 113,5 6,1%; CE50 = 10,92 2,81 μg/mL; n=6), não havendo diferença significante, para os dois compostos, quando comparados aos anéis pré-contraídos com FEN. Sugere-se que tanto EDP quanto FDP atuem sobre os canais para cálcio sensíveis a voltagem (Cav). Além disso, EDP e FDP (0,03; 0,3; 10; 30 e 100 μg/mL) antagonizaram as contrações induzidas por CaCl2. O extrato ainda produziu vasorrelaxamento na presença de um agonista de canais para Ca2+ tipo-L (Bay K 8644; 200 nM) (Emáx = 113,3 6,7% e CE50 = 19,45 6,66 μg/mL, n=7). Esses resultados sugerem que EDP produz hipotensão e bradicardia transientes, e tanto EDP quanto FDP promovem vasorrelaxamento independente do endotélio vascular por inibição do influxo de Ca2+, por meio do bloqueio dos Cav.

The pharmacological effects…

Advisors/Committee Members: Isac Almeida de Medeiros.

Subjects/Keywords: Bloqueador de canais para Ca2+; Artéria mesentérica; Vasorrelaxamento; Dictyota pulchella; FARMACOLOGIA; Vasorelaxant; Dictyota pulchella; Mesenteric artery; Calcium channel blocker

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Queiroz, T. M. d. (2011). Avaliação da atividade vasorrelaxante da alga marinha brasileira Dictyota pulchella Hörning &Schnetter em ratos normotensos. (Thesis). Universidade Federal da Paraíba. Retrieved from http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1780

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Queiroz, Thyago Moreira de. “Avaliação da atividade vasorrelaxante da alga marinha brasileira Dictyota pulchella Hörning &Schnetter em ratos normotensos.” 2011. Thesis, Universidade Federal da Paraíba. Accessed February 28, 2021. http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1780.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Queiroz, Thyago Moreira de. “Avaliação da atividade vasorrelaxante da alga marinha brasileira Dictyota pulchella Hörning &Schnetter em ratos normotensos.” 2011. Web. 28 Feb 2021.

Vancouver:

Queiroz TMd. Avaliação da atividade vasorrelaxante da alga marinha brasileira Dictyota pulchella Hörning &Schnetter em ratos normotensos. [Internet] [Thesis]. Universidade Federal da Paraíba; 2011. [cited 2021 Feb 28]. Available from: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1780.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Queiroz TMd. Avaliação da atividade vasorrelaxante da alga marinha brasileira Dictyota pulchella Hörning &Schnetter em ratos normotensos. [Thesis]. Universidade Federal da Paraíba; 2011. Available from: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1780

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

8. Mueller-Stahl, Christian. The treatment of obesity-related hypertension with the Dihydropyridine calcium channel blocker Lercanidipine.

Degree: 2010, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-4906

► Methods and Results - This was a 14-week, double blind, randomized, multicentre, placebo-controlled, parallel, dose-titration study to assess the efficacy of lercandipine 10 mg and… (more)

Subjects/Keywords: Obesity-related Hypertension; Calcium Channel Blocker; Lercanidipine; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mueller-Stahl, C. (2010). The treatment of obesity-related hypertension with the Dihydropyridine calcium channel blocker Lercanidipine. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-4906

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mueller-Stahl, Christian. “The treatment of obesity-related hypertension with the Dihydropyridine calcium channel blocker Lercanidipine.” 2010. Thesis, Freie Universität Berlin. Accessed February 28, 2021. http://dx.doi.org/10.17169/refubium-4906.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mueller-Stahl, Christian. “The treatment of obesity-related hypertension with the Dihydropyridine calcium channel blocker Lercanidipine.” 2010. Web. 28 Feb 2021.

Vancouver:

Mueller-Stahl C. The treatment of obesity-related hypertension with the Dihydropyridine calcium channel blocker Lercanidipine. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2021 Feb 28]. Available from: http://dx.doi.org/10.17169/refubium-4906.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mueller-Stahl C. The treatment of obesity-related hypertension with the Dihydropyridine calcium channel blocker Lercanidipine. [Thesis]. Freie Universität Berlin; 2010. Available from: http://dx.doi.org/10.17169/refubium-4906

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Islania Giselia Albuquerque Araújo. Efeitos Hipotensor e Vasorrelaxante do Óleo Essencial de Lippia microphylla Cham. e de seu Constituinte Principal Timol: Envolvimento do Bloqueio de Canais para Cálcio.

Degree: 2011, Universidade Federal da Paraíba

URL: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1882

► The genus Lippia (Verbenaceae) has yielded a great number of medicinal and economically important species that are frequently used in folk medicine for treatment of… (more)

▼ The genus Lippia (Verbenaceae) has yielded a great number of medicinal and economically important species that are frequently used in folk medicine for treatment of several diseases, such as: coughs, bronchitis, liver disorders and hypertension. L. microphylla Cham. is a plant of the genus Lippia found in the Northeast of Brazil, and there is no information in the literature concerning its cardiovascular effects. Therefore, this study aimed to evaluate the cardiovascular effects of the essential oil of L. microphylla Cham. (EOLM) and of its main constituent, thymol. In normotensive non-anaesthetized rats, EOLM injections produced hypotension (ED50=5.5 (4.1-7.3) mg/Kg, n=5) and bradycardia (ED50=5.2 (4.3-6.2) mg/Kg, n=5). Isometric tension recordings revealed that EOLM (1300 μg/mL) caused concentration-dependent relaxation in isolated mesenteric rings, with functional endothelium, pre-contracted with phenylephrine (10 μM) (EC50=28.2 (25.3-31.4) μg/mL, n=5) and this effect was not attenuated by removal of the vascular endothelia layer. In preparations without endothelium, pre-incubated with KCl 20 mM, the relaxantion was not changed. Furthermore, EOLM caused relaxation in mesenteric rings pre-contracted with KCl 60 mM and inhibited Ca2+ -induced vasoconstriction in a concentration-dependent manner. In addition, EOLM relaxed the contractions elicited by the L-type Ca2+ channel activator, S(-)-Bay K 8644, indicating that the vasodilatation is related to the inhibition of Ca2+ influx through L-type Ca2+ channels. To confirm this hypothesis, whole-cell L-type Ca2+ currents were recorded in freshly dispersed rat mesenteric artery myocytes. EOLM (1-100 μg/mL) significantly inhibited Ba2+ currents in a concentration-dependent manner (EC50=11.9 (9.4-15.0) μg/mL, n=4).These results suggest that OELM induce vasorelaxant effect in rat mesenteric artery due to the inhibition of the Ca2+ influx via voltage-dependent L-type Ca2+ channels. Interestingly, the relaxantion induced by thymol (EC50=9.3 (8.3-10.4) μg/mL, n=5, p<0.01) was more potent than that observed to EOLM (EC50=23.9 (22.0-26.0) μg/mL, n=5), indicating that the vascular actions of EOLM could be attributed to its main constituent, thymol. The cardiovascular responses evoked by thymol were investigated in SHR and WKY rats. In SHR and WKY non-anaesthetized rats, intravenous administration of thymol (0.1; 0.3; 1; 3; 6; 12 and 15 mg/Kg, i.v.) produced hypotension and bradycardia in a dose-dependent manner. Isometric tension recordings, the pharmacological profile of arterial relaxant effects of thymol was compared in rings of mesenteric arteries and aorta from SHR and WKY. In preparations without endothelium, thymol (1 μM 1 mM) produced relaxation in mesenteric arteries from SHR (pD2=4.40.04, n=5) and WKY (pD2=4.30.02, n=5) and aorta from SHR (pD2 = 4.40.03, n=5) and WKY (pD2=4.30.03, n=5) and this effect was not altered in preparations with functional endothelium. Furthermore, thymol relaxed the… Advisors/Committee Members: Isac Almeida de Medeiros, Jader dos Santos Cruz.

Subjects/Keywords: Óleo essencial; Timol; Lippia microphylla Cham; SHR; Ação vasorrelaxante; Bloqueador de canais para Ca2+; FARMACOLOGIA; Lippia microphylla Cham; Thymol; Essential oil; SHR; Vasorelaxant action; Calcium channel blocker

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Araújo, I. G. A. (2011). Efeitos Hipotensor e Vasorrelaxante do Óleo Essencial de Lippia microphylla Cham. e de seu Constituinte Principal Timol: Envolvimento do Bloqueio de Canais para Cálcio. (Thesis). Universidade Federal da Paraíba. Retrieved from http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Araújo, Islania Giselia Albuquerque. “Efeitos Hipotensor e Vasorrelaxante do Óleo Essencial de Lippia microphylla Cham. e de seu Constituinte Principal Timol: Envolvimento do Bloqueio de Canais para Cálcio.” 2011. Thesis, Universidade Federal da Paraíba. Accessed February 28, 2021. http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Araújo, Islania Giselia Albuquerque. “Efeitos Hipotensor e Vasorrelaxante do Óleo Essencial de Lippia microphylla Cham. e de seu Constituinte Principal Timol: Envolvimento do Bloqueio de Canais para Cálcio.” 2011. Web. 28 Feb 2021.

Vancouver:

Araújo IGA. Efeitos Hipotensor e Vasorrelaxante do Óleo Essencial de Lippia microphylla Cham. e de seu Constituinte Principal Timol: Envolvimento do Bloqueio de Canais para Cálcio. [Internet] [Thesis]. Universidade Federal da Paraíba; 2011. [cited 2021 Feb 28]. Available from: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Araújo IGA. Efeitos Hipotensor e Vasorrelaxante do Óleo Essencial de Lippia microphylla Cham. e de seu Constituinte Principal Timol: Envolvimento do Bloqueio de Canais para Cálcio. [Thesis]. Universidade Federal da Paraíba; 2011. Available from: http://bdtd.biblioteca.ufpb.br/tde_busca/arquivo.php?codArquivo=1882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

10. Schwarzwald, Colin C. Atrial and AV-nodal physiology in horses: Electrophysiologic and echocardiographic characterization and pharmacologic effects of diltiazem.

Degree: PhD, Veterinary Clinical Sciences, 2006, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1158079213

► Atrial fibrillation (AF) is considered the most common arrhythmia affecting exercise performance in horses. Quinidine is an effective therapy for conversion of AF to sinus… (more)

▼ Atrial fibrillation (AF) is considered the most common arrhythmia affecting exercise performance in horses. Quinidine is an effective therapy for conversion of AF to sinus rhythm, but treatment is associated with a number of adverse clinical effects. Furthermore, residual electrical and mechanical abnormalities of the equine atria may account for the recurrence of AF following successful therapy. Relative to these issues, we sought to better understand the physiology of the in vivo equine atria and the associated sinoatrial and atrioventricular (AV) nodal tissues. In treating horses with AF using the drug quinidine, a common adverse effect is marked acceleration of the ventricular response rate prompting early discontinuation of treatment. Diltiazem effectively controls ventricular response to AF in other species, but has not been evaluated in horses. In our first series of experiments we studied the pharmacodynamic and pharmacokinetic effects of the calcium channel blocker diltiazem on the cardiovascular system in healthy horses in sinus rhythm. To further support these studies we characterized the clinical electrophysiology of the normal equine atria and then quantified the electrophysiologic effects of quinidine and diltiazem in a pacing model of atrial tachycardia. Based on our studies demonstrating inhibitory effects on AV nodal conduction, diltiazem is likely to be useful for ventricular rate control in horses with naturally occurring AF undergoing quinidine treatment. Diltiazem appeared relatively safe in healthy horses, but dosage may be limited by hypotension from vasodilatation and direct suppression of sinus node discharge. In our last two studies, we established echocardiographic techniques to assess mechanical function of the equine left atrium noninvasively and applied these methods to a subset of horses recently converted from AF to normal sinus rhythm. Our preliminary guidelines for echocardiographic assessment of LA size and mechanical function will likely be useful to study LA function in horses with cardiac disease. Specifically, we were able to show that LA mechanical function in horses can be significantly depressed after successful conversion of AF to sinus rhythm. The clinical relevance of these findings will have to be established in future investigations. Advisors/Committee Members: Bonagura, John (Advisor).

Subjects/Keywords: Horse; equine; cardiology; atrial physiology; electrophysiology; echocardiography; atrial mechanical function; calcium channel blocker; diltiazem; pharmacokinetics; atrial fibrillation; atrial arrhythmia; atrial remodeling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schwarzwald, C. C. (2006). Atrial and AV-nodal physiology in horses: Electrophysiologic and echocardiographic characterization and pharmacologic effects of diltiazem. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1158079213

Chicago Manual of Style (16^th Edition):

Schwarzwald, Colin C. “Atrial and AV-nodal physiology in horses: Electrophysiologic and echocardiographic characterization and pharmacologic effects of diltiazem.” 2006. Doctoral Dissertation, The Ohio State University. Accessed February 28, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1158079213.

MLA Handbook (7^th Edition):

Schwarzwald, Colin C. “Atrial and AV-nodal physiology in horses: Electrophysiologic and echocardiographic characterization and pharmacologic effects of diltiazem.” 2006. Web. 28 Feb 2021.

Vancouver:

Schwarzwald CC. Atrial and AV-nodal physiology in horses: Electrophysiologic and echocardiographic characterization and pharmacologic effects of diltiazem. [Internet] [Doctoral dissertation]. The Ohio State University; 2006. [cited 2021 Feb 28]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1158079213.

Council of Science Editors:

Schwarzwald CC. Atrial and AV-nodal physiology in horses: Electrophysiologic and echocardiographic characterization and pharmacologic effects of diltiazem. [Doctoral Dissertation]. The Ohio State University; 2006. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1158079213

The Ohio State University

11. Dowell, Margaret Anne. Influence of three-tier cost sharing on patient compliance with and switching of cardiovascular medications.

Degree: MS, Pharmacy, 2002, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1030118543

► Compliance with prescribed drug regimens can reduce health care spending while improving patient outcomes. Managed care organizations have begun requiring members to pay a higher… (more)

▼ Compliance with prescribed drug regimens can reduce health care spending while improving patient outcomes. Managed care organizations have begun requiring members to pay a higher proportion of costs for non-preferred brand drugs, a plan known as an incented formulary or tiered cost sharing. This study has two goals, to evaluate whether an incented formulary is associated with a change in patient compliance, and to discover whether patients switch to lower-cost medications after a cost-share increase for non-preferred brands. A retrospective database analysis of the prescription drug claims for a health plan that implemented an incented formulary was performed. Four cardiovascular drug classes were analyzed, Angiotensin Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, Calcium Channel Blockers, and HMG CoA Reductase Inhibitors. Multivariate linear regression was used to explain the relationship between implementation of the incented formulary and difference in compliance measured using the Medication Possession Ratio (MPR) while controlling for covariates. No difference was found in changes in medication compliance between users of non-preferred brand drugs and users of preferred brand or generic drugs. Users of mail order pharmacy were more compliant than users of retail pharmacy. Analysis of switching among drug products using the Mantel-Haenszel chi square test of association estimated the effectiveness of the incented formulary implementation. Almost half of all subjects taking a non-preferred brand drug switched to a generic or preferred brand drug. Furthermore, efforts by the health plan to inform members of the change were not as effective as the cost share increase in encouraging members to switch to a lower-cost medication. Subjects were most likely to switch immediately after the cost-share increase. Subjects who used mail order at least once were three times more likely to switch drugs as those who used retail pharmacy exclusively. This thesis describes changes in refill compliance and switching of drug products after the implementation of an incented formulary. Including an incented formulary in a pharmacy benefit plan can save money for the plan while not reducing patient compliance with prescription drugs. Advisors/Committee Members: Pedersen, Craig (Advisor).

Subjects/Keywords: three-tier cost sharing; incented formulary; compliance; medication possession ratio; cardiovascular medication; angiotensin converting enzyme inhibitor; angiotensin receptor blocker; calcium channel blocker; HMG CoA reductase inhibitor; cost share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dowell, M. A. (2002). Influence of three-tier cost sharing on patient compliance with and switching of cardiovascular medications. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1030118543

Chicago Manual of Style (16^th Edition):

Dowell, Margaret Anne. “Influence of three-tier cost sharing on patient compliance with and switching of cardiovascular medications.” 2002. Masters Thesis, The Ohio State University. Accessed February 28, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1030118543.

MLA Handbook (7^th Edition):

Dowell, Margaret Anne. “Influence of three-tier cost sharing on patient compliance with and switching of cardiovascular medications.” 2002. Web. 28 Feb 2021.

Vancouver:

Dowell MA. Influence of three-tier cost sharing on patient compliance with and switching of cardiovascular medications. [Internet] [Masters thesis]. The Ohio State University; 2002. [cited 2021 Feb 28]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1030118543.

Council of Science Editors:

Dowell MA. Influence of three-tier cost sharing on patient compliance with and switching of cardiovascular medications. [Masters Thesis]. The Ohio State University; 2002. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1030118543

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Open Access Theses and Dissertations