subject:(Ca 60)

Marshall University

1. Wimmer, Joshua Dean. Lend Me Your Voice: Discovering Romanity in Seneca's De otio and De brevitate vitae.

Degree: 2012, Marshall University

► This thesis is primarily concerned with the theory that the writings of Seneca the Younger display an array of stylistic choices theretofore unprecedented in the… (more)

Subjects/Keywords: <; p>; Seneca, Lucius Annaeus, ca. 4 B.C.-65 A.D. De brevitate vitae.<; /p>; <; p>; Seneca, Lucius Annaeus,<; strong>; <; /strong>; ca. 4 B.C.-65 A.D.<; strong>; <; /strong>; De otio<; /p>; <; p>; Seneca, Lucius Annaeus,<; strong>; <; /strong>; ca. 4 B.C.-65 A.D. - Criticism and interpretation.<; /p>;

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wimmer, J. D. (2012). Lend Me Your Voice: Discovering Romanity in Seneca's De otio and De brevitate vitae. (Thesis). Marshall University. Retrieved from https://mds.marshall.edu/etd/255

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wimmer, Joshua Dean. “Lend Me Your Voice: Discovering Romanity in Seneca's De otio and De brevitate vitae.” 2012. Thesis, Marshall University. Accessed March 01, 2021. https://mds.marshall.edu/etd/255.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wimmer, Joshua Dean. “Lend Me Your Voice: Discovering Romanity in Seneca's De otio and De brevitate vitae.” 2012. Web. 01 Mar 2021.

Vancouver:

Wimmer JD. Lend Me Your Voice: Discovering Romanity in Seneca's De otio and De brevitate vitae. [Internet] [Thesis]. Marshall University; 2012. [cited 2021 Mar 01]. Available from: https://mds.marshall.edu/etd/255.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wimmer JD. Lend Me Your Voice: Discovering Romanity in Seneca's De otio and De brevitate vitae. [Thesis]. Marshall University; 2012. Available from: https://mds.marshall.edu/etd/255

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oulu

2. Sallinen, P. (Pirkko). Myocardial infarction:aspects relating to endogenous and exogenous melatonin and cardiac contractility.

Degree: 2008, University of Oulu

URL: http://urn.fi/urn:isbn:9789514287558

►

Abstract Melatonin is an important modulator of several physiological and behavioural processes, and it influences the function of many different tissues. Melatonin has effective antioxidative… (more)

▼

Abstract Melatonin is an important modulator of several physiological and behavioural processes, and it influences the function of many different tissues. Melatonin has effective antioxidative properties, but some of its actions in mammals are also mediated through the MT1 and MT2 melatonin receptors. Antioxidative properties are seen especially when the melatonin concentration is high (≥ nM), and melatonin's affinity for its receptors appears at lower concentrations (pM). Recently, the involvement of melatonin in protecting the heart against cardiac diseases, including myocardial infarction (MI), has been brought out. MI alters the structure and function of myocardium, attenuating for example cardiac contractility by affecting the amount and function of the essential Ca2+ handling proteins, dihydropyridine receptor (DHPR), ryanodine receptor (RyR2) and sarco-endoplasmic reticulum (SR) Ca2+-ATPase2 (SERCA2). MI also evokes many adaptive responses in organisms, such as elevated production of atrial and brain natriuretic peptides (ANP and BNP). In this thesis, the expression of MT1 and MT2 receptor mRNAs was investigated in several rat tissues. Furthermore, the effect of MI and exogenous melatonin on the rat endogenous melatonin and on the expression of cardiac MT1, MT2, DHPR, RyR2 and SERCA2 proteins was evaluated. The concentrations of ANP and BNP were also measured after post-MI melatonin administration. The results show the expression of MT1 and/or MT2 receptor mRNAs in the hypothalamus, retina, small intestine, liver and heart, which indicates that at least some effects of melatonin could be mediated through the receptors in these tissues. Melatonin synthesis in the pineal gland increased rapidly in response to MI, supporting an important role of endogenous melatonin in protecting the heart after MI. Furthermore, exogenous melatonin altered the mRNA expression of DHPR, RyR2 and SERCA2 after MI, suggesting that melatonin might contribute to the post-infarction cardiac contractile function. The results also revealed a novel, positive relationship between melatonin and ANP, and thereby bring out one more possible way of melatonin to protect the heart against MI-induced injuries. Taken together, the present thesis (i) supports the notion that melatonin is an important endogenous protective agent of the organism, and (ii) extends our knowledge of melatonin's post-infarction cardioprotective actions.

Tiivistelmä Melatoniini osallistuu monien fysiologisten toimintojen ja käyttäytymisen säätelyyn sekä vaikuttaa useiden eri kudosten toimintaan. Melatoniini on tehokas antioksidantti, mutta jotkut sen vaikutuksista välittyvät myös MT1 ja MT2 melatoniini reseptorien kautta. Antioksidatiiviset vaikutukset tulevat esiin erityisesti silloin, kun melatoniinin pitoisuus on korkea (≥ nM). Alhaisemmilla pitoisuuksilla (pM) on puolestaan havaittavissa melatoniinin sitoutuminen reseptoreihinsa. Viime aikoina on tullut esille melatoniinin mahdollinen suojavaikutus sydänsairauksia, kuten sydäninfarkteja, vastaan.…

Subjects/Keywords: MT<; sub>; 1<; /sub>;

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sallinen, P. (. (2008). Myocardial infarction:aspects relating to endogenous and exogenous melatonin and cardiac contractility. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789514287558

Chicago Manual of Style (16^th Edition):

Sallinen, P (Pirkko). “Myocardial infarction:aspects relating to endogenous and exogenous melatonin and cardiac contractility.” 2008. Doctoral Dissertation, University of Oulu. Accessed March 01, 2021. http://urn.fi/urn:isbn:9789514287558.

MLA Handbook (7^th Edition):

Sallinen, P (Pirkko). “Myocardial infarction:aspects relating to endogenous and exogenous melatonin and cardiac contractility.” 2008. Web. 01 Mar 2021.

Vancouver:

Sallinen P(. Myocardial infarction:aspects relating to endogenous and exogenous melatonin and cardiac contractility. [Internet] [Doctoral dissertation]. University of Oulu; 2008. [cited 2021 Mar 01]. Available from: http://urn.fi/urn:isbn:9789514287558.

Council of Science Editors:

Sallinen P(. Myocardial infarction:aspects relating to endogenous and exogenous melatonin and cardiac contractility. [Doctoral Dissertation]. University of Oulu; 2008. Available from: http://urn.fi/urn:isbn:9789514287558

3. Choo, Hyeran. Ca²+/calmodulin-dependent protein kinase II regulates the growth of human osteosarcoma cells in vivo.

Degree: MS, 2007, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,300

►

Osteosarcoma is the most predominant primary bone cancer among pediatric patients. The pathogenesis and mechanism of osteosarcoma, however, as yet remains unclear. This study investigated… (more)

▼

Osteosarcoma is the most predominant primary bone cancer among pediatric patients. The pathogenesis and mechanism of osteosarcoma, however, as yet remains unclear. This study investigated the hypothesis that Ca2+/calmodulin-dependent protein kinase II (CaMK II), activated by Ca2+ and its intracellular receptor, calmodulin, plays a critical role in the growth of human osteosarcoma cells. The inhibition of CaMK II with its pharmacologic antagonist KN-93 was used to investigate the role of CaMK II in the growth of human osteosarcoma cells because our preliminary data showed that =-CaMK II is expressed in several human osteosarcoma cell lines. To examine the in vivo effects of KN-93 on human osteosarcoma cells, MG-63 cells and Saos-2 cells were subcutaneously inoculated in 5-week-old male athymic nude mice. The mice were then treated with either KN-93 or phosphate buffered saline every other day for 6 weeks. The tumor cells were also inoculated in the tibia of the mice at the same time when mice received subcutaneous inoculation. The final total volume of subcutaneous tumors of KN-93-treated group was 40% smaller in MG-63 cells and 41 % smaller in Saos-2 cells than that of each control group at sacrifice. Supporting these findings, micro-computerized tomography of mouse tibia where MG-63 cells were grown provided another line of evidence that pathologic bone formation by osteosarcoma cells was decreased by KN-93 treatment. Further, immunohistochemistry staining on these samples demonstrated that the expression of p21 was significantly increased while that of p-Rb was decreased in the KN-93-treated group. These results suggest that p21-involving signaling cascade mediated by CaMK II may be one of the potential mechanisms controlling the growth of human osteosarcoma cells, which will warrant further investigations aiming at a novel target to treat human osteosarcomas.

M.S.

vii, 40 p. : ill., digital, PDF file.

Orthodontics

Dentistry

Osteosarcoma In Vivo KN-92 CaMK

UNRESTRICTED

Advisors/Committee Members: Sadowsky, P. Lionel, Jacobson, Alex , Rahemtulla, Firoz , Zayzafoon, Majid.

Subjects/Keywords: Ca(2+)-Calmodulin Dependent Protein Kinase – antagonists & inhibitors <; br>; Ca(2+)-Calmodulin Dependent Protein Kinase – metabolism <; br>; Mice <; br>; Osteosarcoma – metabolism <; br>; Protein Kinase Inhibitors – pharmacology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Choo, H. (2007). Ca²+/calmodulin-dependent protein kinase II regulates the growth of human osteosarcoma cells in vivo. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,300

Chicago Manual of Style (16^th Edition):

Choo, Hyeran. “Ca²+/calmodulin-dependent protein kinase II regulates the growth of human osteosarcoma cells in vivo.” 2007. Masters Thesis, University of Alabama – Birmingham. Accessed March 01, 2021. http://contentdm.mhsl.uab.edu/u?/etd,300.

MLA Handbook (7^th Edition):

Choo, Hyeran. “Ca²+/calmodulin-dependent protein kinase II regulates the growth of human osteosarcoma cells in vivo.” 2007. Web. 01 Mar 2021.

Vancouver:

Choo H. Ca²+/calmodulin-dependent protein kinase II regulates the growth of human osteosarcoma cells in vivo. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2007. [cited 2021 Mar 01]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,300.

Council of Science Editors:

Choo H. Ca²+/calmodulin-dependent protein kinase II regulates the growth of human osteosarcoma cells in vivo. [Masters Thesis]. University of Alabama – Birmingham; 2007. Available from: http://contentdm.mhsl.uab.edu/u?/etd,300

4. Sullivan, Kathryn Amanda. Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara.

Degree: MA, 2009, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,1110

►

In our present day, the term “chivalry” is understood to define the gentlemanly conduct of a man with respects to a female counterpart. In the… (more)

▼

In our present day, the term “chivalry” is understood to define the gentlemanly conduct of a man with respects to a female counterpart. In the fifteenth century, the term “chivalry” is applied in a broader sense, referring to the inter-dynamics of a grouping of knights. “Chivalry” thus examines the bachelorhood of the knight and the magnanimous and egalitarian nature of his position. Italians have been aware of Arthurian legends since at least the eleventh century. In fifteenth century Northern Italy, chivalric literature enjoyed refreshed interest due to an outpouring of Italian and French translations. Borso d’Este (1413-1471), although illegitimate, was the second sovereign son of Niccolò III d’Este of Ferrara. Borso’s illegitimacy and lifestyle made it advantageous for him to embody a knightly persona. In doing so, he employed a variety of artistic campaigns that hyperbolized his pedigree. This thesis focuses on one of these campaigns, the Hall of the Months, in the Palazzo Schifanoia, an Este hunting retreat on the outskirts of Ferrara. Francesco del Cossa and Cosmè Tura painted the Hall of the Months. The program for the fresco cycle is complex. The twelve calendar months run clockwise around the room. Horizontally, the hall is divided into three registers, from bottom to top: earth, corresponding zodiacal signs, and corresponding deities. Considering the 1:1 scaling and expansive proportions of the Hall of the Months (24 m long, 11 m long, and 7.5 m high), the earthly tier illusionistically places viewers outdoors and serve as a reminder of Borso’s place among sovereigns. Themes of civic harmony abated any fear of discord or aggression. Previous scholarship has tended to focus on the astrological aspects of the Hall of the Months. However, its chivalric imagery has either been neglected or not fully explored. Thus, this thesis focuses only on the “earthly” register, whose chivalric imagery promulgates Borso’s carefully crafted persona. By providing a new focus of interest for the Hall of the Months, I hope to open the field to further research about Borso’s biography as well as the importance of chivalric literature in fifteenth-century Italy and in fifteenth-century Italian art.

M.A.

1 online resource (xi, 76 p.) : ill. (chiefly col.), geneal. table, map, plans.

Art and Art History

College of Arts and Sciences

Borso d’Este Chivalry Ferrara Hall of the Months Italian Renaissance Schifanoia

UNRESTRICTED

Advisors/Committee Members: McIver, Katherine A., Dallow, Jessica , Nancarrow, Mindy.

Subjects/Keywords: Mural painting and decoration – Italy – Ferrara <; br>; Arthurian romances in art <; br>; Chivalry in art <; br>; Salone dei Mesi (Museo civico d'arte antica di Palazzo Schifanoia) <; br>; Borso d'Este, Duke of Ferrara, Modena, and Reggio, 1413-1471 – Art patronage <; br>; Este family – Art patronage <; br>; Cossa, Francesco del, ca. 1435-ca. 1477 – Criticism and interpretation <; br>; Tura, Cosmè, ca. 1430-1495 – Criticism and interpretation

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sullivan, K. A. (2009). Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1110

Chicago Manual of Style (16^th Edition):

Sullivan, Kathryn Amanda. “Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara.” 2009. Masters Thesis, University of Alabama – Birmingham. Accessed March 01, 2021. http://contentdm.mhsl.uab.edu/u?/etd,1110.

MLA Handbook (7^th Edition):

Sullivan, Kathryn Amanda. “Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara.” 2009. Web. 01 Mar 2021.

Vancouver:

Sullivan KA. Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2009. [cited 2021 Mar 01]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1110.

Council of Science Editors:

Sullivan KA. Borso d'Este and the Arthurian legend : a reconsideration of the Hall of the Months in the Palazzo Schifanoia, Ferrara. [Masters Thesis]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1110

5. Fox, Emma C. The Journey of the Queen of Sheba and The Meeting of Solomon and Sheba : two cassone panels from the workshop of Apollonio di Giovanni.

Degree: MA, 2008, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,797

►

In the Kress Gallery of the Birmingham Museum of Art is a painted panel of the Journey of the Queen of Sheba, created by the… (more)

▼

In the Kress Gallery of the Birmingham Museum of Art is a painted panel of the Journey of the Queen of Sheba, created by the Florentine workshop of Apollonio di Giovanni and Marco del Buono in the mid-fifteenth century. Its companion panel, The Meeting of Solomon and the Queen of Sheba, is housed in the collection of the Museum of Fine Arts, Boston. Together, these two artworks once formed the fronts of a pair of elegant marriage chests, often referred to as cassoni. Although these panels have been reproduced and briefly discussed in several publications, they have never been given a thorough analysis. My thesis project fills this gap with an in-depth study of these two panels, replacing them as much as possible into their historic context in order to comprehend their original role and significance. In the process, I have not only compiled previous research on my topic, but also forged ahead to discover the original patron of these chests, who was previously unknown. In my thesis, I begin with the social context of marriage cassoni in fifteenthcentury Florence, considering the role that these chests once played in both the public rituals of marriage and the private domestic culture of the home. Next, I survey the workshop in which these chests were produced: the various domestic products it created, the stylistic development evident in surviving works, and the process by which the elegant marriage cassoni were crafted. I then consider the iconography of the Queen of Sheba, tracing her story’s evolution through history from the time of King Solomon through the mid-fifteenth century, and exploring the ways in which the panels in Birmingham and Boston weave together the Queen’s traditional iconography with contemporary artworks and events. Finally, I investigate the issue of patronage. Beginning with my identification of the Pitti coat of arms in The Meeting of Solomon and the Queen of Sheba, I consider possible candidates for the patron of this cassone pair. I determine that, in all likelihood, it was Luca Pitti who commissioned these domestic artworks for his daughter’s marriage to Francesco Segni in 1459.

M.A.

1 online resource (xii, 112 p.) : ill. (chiefly col.)

Art and Art History

College of Arts and Sciences

UNRESTRICTED

Advisors/Committee Members: McIver, Katherine A., McPherson, Heather , Nancarrow, Mindy.

Subjects/Keywords: Apollonio di Giovanni, ca. 1415-1465 – Criticism and interpretation <; br>; Apollonio di Giovanni, ca. 1415-1465. Journey of the Queen of Sheba <; br>; Apollonio di Giovanni, ca. 1415-1465. Meeting of Solomon and the Queen of Sheba <; br>; Painted cassoni – Italy – Florence <; br>; Marriage customs and rites – Italy – Florence <; br>; Sheba, Queen of – Art <; br>; Solomon, King of Israel – Art <; br>; Pitti family – Art patronage

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fox, E. C. (2008). The Journey of the Queen of Sheba and The Meeting of Solomon and Sheba : two cassone panels from the workshop of Apollonio di Giovanni. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,797

Chicago Manual of Style (16^th Edition):

Fox, Emma C. “The Journey of the Queen of Sheba and The Meeting of Solomon and Sheba : two cassone panels from the workshop of Apollonio di Giovanni.” 2008. Masters Thesis, University of Alabama – Birmingham. Accessed March 01, 2021. http://contentdm.mhsl.uab.edu/u?/etd,797.

MLA Handbook (7^th Edition):

Fox, Emma C. “The Journey of the Queen of Sheba and The Meeting of Solomon and Sheba : two cassone panels from the workshop of Apollonio di Giovanni.” 2008. Web. 01 Mar 2021.

Vancouver:

Fox EC. The Journey of the Queen of Sheba and The Meeting of Solomon and Sheba : two cassone panels from the workshop of Apollonio di Giovanni. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2008. [cited 2021 Mar 01]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,797.

Council of Science Editors:

Fox EC. The Journey of the Queen of Sheba and The Meeting of Solomon and Sheba : two cassone panels from the workshop of Apollonio di Giovanni. [Masters Thesis]. University of Alabama – Birmingham; 2008. Available from: http://contentdm.mhsl.uab.edu/u?/etd,797

University of Cincinnati

6. Liu, Li. Roles of PMCA Isoforms in Ca²⁺-Homeostasis and Contractility of Bladder Smooth Muscle: Evidence from PMCA Gene-Ablated Mice.

Degree: PhD, Medicine : Molecular and Cellular Physiology, 2007, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1178307168

► Plasma membrane Ca²⁺ ATPase (PMCA) has four main isoforms encoded by different genes, but only PMCA1 and 4 are expressed in smooth muscle. We investigated… (more)

Subjects/Keywords: PMCA (human gene symbols; ATP2B); SERCA2 (human gene symbols; ATP2A2); NCX; bladder smooth muscle; Ca<; sup>; 2+<; /sup>; homeostasis; gene-altered mice. Ca<; sup>; 2+<; /sup>; waves; Ca<; sup>; 2+<; /sup>; sparks; Fura-PE3; Fluo-4; Indo-1; multi-photon microscopy

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, L. (2007). Roles of PMCA Isoforms in Ca²⁺-Homeostasis and Contractility of Bladder Smooth Muscle: Evidence from PMCA Gene-Ablated Mice. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1178307168

Chicago Manual of Style (16^th Edition):

Liu, Li. “Roles of PMCA Isoforms in Ca²⁺-Homeostasis and Contractility of Bladder Smooth Muscle: Evidence from PMCA Gene-Ablated Mice.” 2007. Doctoral Dissertation, University of Cincinnati. Accessed March 01, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1178307168.

MLA Handbook (7^th Edition):

Liu, Li. “Roles of PMCA Isoforms in Ca²⁺-Homeostasis and Contractility of Bladder Smooth Muscle: Evidence from PMCA Gene-Ablated Mice.” 2007. Web. 01 Mar 2021.

Vancouver:

Liu L. Roles of PMCA Isoforms in Ca²⁺-Homeostasis and Contractility of Bladder Smooth Muscle: Evidence from PMCA Gene-Ablated Mice. [Internet] [Doctoral dissertation]. University of Cincinnati; 2007. [cited 2021 Mar 01]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1178307168.

Council of Science Editors:

Liu L. Roles of PMCA Isoforms in Ca²⁺-Homeostasis and Contractility of Bladder Smooth Muscle: Evidence from PMCA Gene-Ablated Mice. [Doctoral Dissertation]. University of Cincinnati; 2007. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1178307168

7. Dick, Christina Sorrell. The mother in seventeenth-century Dutch art.

Degree: MA, 2009, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,548

►

The mother is a prominent figure in the art of the seventeenth-century Dutch Republic. Artists used the mother to show virtues that should be taught… (more)

▼

The mother is a prominent figure in the art of the seventeenth-century Dutch Republic. Artists used the mother to show virtues that should be taught to children. It was her example that not only educated her children in how to act, but also ensured that the Dutch society would be moral. This thesis examines how painters used the image of the mother to represent the ideal and to prompt the mothers to reach this virtue. It will explore some of the numerous images of seventeenth-century Dutch mothers and will examine how these images reflect the spiritual and moral beliefs of society. It will investigate why these images were so popular and why leading painters such as Pieter de Hooch, Nicolaes Maes, and Jan Steen produced so many of these images. By examining three types of images, the mother as physical nourisher, the mother as educator, the mother as disciplinarian, this thesis will prove that Dutch society not only ardently adhered to these principles, but also praised the women who exemplified them. It begins by focusing on images that deal with the mother providing nourishment for her child and will present an overview of the importance of the nursing mother within society and address the religious implications placed on the mother who refused to nurse. It will explore how the mother becomes the life sustainer of society. Next, it will show how it remains the mother’s responsibility to provide proper nourishment for her children as they grow. The mother’s role as educator will then be examined. This chapter will address the church’s view on education and why such tasks were considered important. Finally, the mother will be shown in the role of disciplinarian by looking at images of instruction by Dutch mothers. These images will uncover not only what behaviors were deemed acceptable within society but also why it was the mother’s responsibility to correct the child. By examining the mother in these three roles, this thesis will show how she became a representation of the ideal mother meant to inspire the Dutch women.

M.A.

1 online resource (ix, 76 p.) : ill. (some col.), digital, PDF file.

Art and Art History

Arts and Humanities

UNRESTRICTED

Advisors/Committee Members: McIver, Katherine A., McPherson, Heather , Mellown, Robert.

Subjects/Keywords: Mothers in art – 17th century – History and criticism <; br>; Art, Dutch – 17th century – History and criticism <; br>; Hooch, Pieter de – Criticism and interpretation <; br>; Maes, Nicolaes, ca. 1634-1693 – Criticism and interpretation <; br>; Steen, Jan, 1626-1679 – Criticism and interpretation.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dick, C. S. (2009). The mother in seventeenth-century Dutch art. (Masters Thesis). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,548

Chicago Manual of Style (16^th Edition):

Dick, Christina Sorrell. “The mother in seventeenth-century Dutch art.” 2009. Masters Thesis, University of Alabama – Birmingham. Accessed March 01, 2021. http://contentdm.mhsl.uab.edu/u?/etd,548.

MLA Handbook (7^th Edition):

Dick, Christina Sorrell. “The mother in seventeenth-century Dutch art.” 2009. Web. 01 Mar 2021.

Vancouver:

Dick CS. The mother in seventeenth-century Dutch art. [Internet] [Masters thesis]. University of Alabama – Birmingham; 2009. [cited 2021 Mar 01]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,548.

Council of Science Editors:

Dick CS. The mother in seventeenth-century Dutch art. [Masters Thesis]. University of Alabama – Birmingham; 2009. Available from: http://contentdm.mhsl.uab.edu/u?/etd,548

University of Oulu

8. Han, C. (Chunlei). Intracellular calcium stores and sodium-calcium exchanger in cardiac myocytes:experimental and computer simulation study.

Degree: 2001, University of Oulu

URL: http://urn.fi/urn:isbn:9514265912

► Abstract Cytosolic Ca2+, [Ca2+]I , has a key role in intracellular signalling during excitation-contraction coupling (E-C coupling) in cardiac myocytes. The sarcoplasmic reticulum (SR) is… (more)

▼ Abstract Cytosolic Ca2+, [Ca2+]I , has a key role in intracellular signalling during excitation-contraction coupling (E-C coupling) in cardiac myocytes. The sarcoplasmic reticulum (SR) is a main intracellular Ca2+ store and the Na+-Ca2+ exchanger (NaCaX) is a major mechanism to extrude Ca2+ for balancing the Ca2+ influx via L-type Ca2+ channels during excitation. Furthermore, [Ca2+]I also affects the configuration of the action potential (AP). The present study, by combination of animal experiments and computer simulations, investigated the roles of [Ca2+]I, SR and NaCaX in cardiac myocytes, in Ca2+-induced Ca2+ release (CICR) and in modulation of APs. The following were studied: (I) the stretch-induced effects on rat atrium and the role of [Ca2+]I in modulation of AP; (II) the role of the SR in modulation in rat atrium by stretch; (III) the role of NaCaX; (IV) the role of [Ca2+]I in modulation of action potential duration (APD) in myocytes with short and long action potential duration. In isolated rat atrial preparations, the physiological or moderate stretch stimulus caused two- phasic rise of developed contraction, rapid and slow phases, accompanied with slow increments of [Ca2+]I and prolongations of action potentials durations in continuous recordings. In sustained stretch, the APD and [Ca2+]I were all increased significantly when intra-atrial pressure increased from 1 to 3 mmHg. In computer simulations, employing a rat atrial model (RA model), it was found that stretch-activated channels and increased Tn C affinity for Ca2+ alone could not produce the changes in the experiments. Only after both mechanisms applied to model cells, the main experimental findings could be mimicked (I). The prolongation of APD induced by stretch in rat atrial preparations was reversed after depleting the Ca2+ content of the SR by application of the SR functional inhibitors, ryanodine, thapsigargin and caffeine (II). In the computer simulation using modified guinea pig ventricular model, the Ca2+ entry via the reversal of NaCaX was found to be accounting 25% of the total activator Ca2+ for triggering Ca2+ release from the SR during normal excitation. This contribution increases with elevated [Na+]i (III). In a guinea pig ventricular model (GPV model) and a RA model were employed for investigating the regulation of APD by [Ca2+]I-dependent membrane currents. Increased SR Ca2+ content produced an elevated [Ca2+]I in both model cells, leading to prolongation of APD in the RA model but shortening in the GPV model. Increased [Ca2+]I enhances the NaCaX current in the same scale in both models, but inhibits L-type Ca current much more in the GPV model than the RA model (IV). In conclusion, (I) Stretch-induced [Ca2+]I increase prolongs the rat atrial AP by enhancing the NaCaX inward current. Stretch-activated channels (SACs) and increased affinity of TnC for Ca2+ are main general factors responsible for the variety of changes of cardiac muscles…

Subjects/Keywords: E-C coupling; Na<; sup>; +<; /sup>; -Ca<; sup>; 2+<; /sup>; exchanger; action potential; intracellular calcium; mathematical modelling

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Han, C. (. (2001). Intracellular calcium stores and sodium-calcium exchanger in cardiac myocytes:experimental and computer simulation study. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9514265912

Chicago Manual of Style (16^th Edition):

Han, C (Chunlei). “Intracellular calcium stores and sodium-calcium exchanger in cardiac myocytes:experimental and computer simulation study.” 2001. Doctoral Dissertation, University of Oulu. Accessed March 01, 2021. http://urn.fi/urn:isbn:9514265912.

MLA Handbook (7^th Edition):

Han, C (Chunlei). “Intracellular calcium stores and sodium-calcium exchanger in cardiac myocytes:experimental and computer simulation study.” 2001. Web. 01 Mar 2021.

Vancouver:

Han C(. Intracellular calcium stores and sodium-calcium exchanger in cardiac myocytes:experimental and computer simulation study. [Internet] [Doctoral dissertation]. University of Oulu; 2001. [cited 2021 Mar 01]. Available from: http://urn.fi/urn:isbn:9514265912.

Council of Science Editors:

Han C(. Intracellular calcium stores and sodium-calcium exchanger in cardiac myocytes:experimental and computer simulation study. [Doctoral Dissertation]. University of Oulu; 2001. Available from: http://urn.fi/urn:isbn:9514265912

University of Oulu

9. Piuhola, J. (Jarkko). Regulation of cardiac responses to increased load:role of endothelin-1, angiotensin II and collagen XV.

Degree: 2002, University of Oulu

URL: http://urn.fi/urn:isbn:9514267214

► Abstract Chronic overload of the heart is the major cause of left ventricular hypertrophy (LVH) and eventually heart failure. It is generally accepted that autocrine/paracrine… (more)

▼ Abstract Chronic overload of the heart is the major cause of left ventricular hypertrophy (LVH) and eventually heart failure. It is generally accepted that autocrine/paracrine factors, such as angiotensin II (Ang II) and endothelin-1 (ET-1) contribute to the development of LVH. Cardiac hypertrophy and failure are characterized by attenuated responsiveness to β- adrenergic stimulation and accumulation of collagenous material to the left ventricular wall. The present study aimed to characterize the roles of ET-1 and Ang II in the regulation of cardiac function. The role of the plasmamembrane Ca2+-ATPase (PMCA) in ET-1 induced cardiac responses and the role of type XV collagen in cardiac function were also studied. Both ET-1 infusion and mechanical loading were able to induce positive inotropic effect and induction of early response genes in isolated perfused hearts. ET-1 also induced strong vasoconstriction. Cardiomyocyte-specific PMCA overexpression inhibited the ET-1 induced hypertrophic response, while inotropic response remained unaltered. ET-1 was found to induce release of adrenomedullin (AM), a potent vasorelaxing and inotropic peptide. Infusion of AM antagonized the vasoconstrictive effect of ET-1 independently of nitric oxide. In hypertrophied rat hearts ET-1 was found to contribute significantly to the Frank-Starling response, a fundamental mechanism regulating contractile performance of the heart. In mice hearts, ET-1 was found to play a dual role in load induced elevation of contractile strength: ETA receptors mediated an increase, while ETB receptors mediated an inhibitory effect on contrcatile force. Ang II was not contributing to the contractile response to load in either rat or mice hearts. Blunted response to β-adrenergic stimulus and increased vulnerability as a result of exercise was observed in mice lacking collagen XV. In conclusion, the present results underscore the importance of the local factors, especially ET-1, in regulation of cardiac function, not only in terms of hypertrophic but also in terms of contractile response to load. The results also suggest a role for PMCA in regulation of cardiac function. Lack of type XV collagen was found to result in cardiac dysfunction with many features similar to those of early heart failure.

Subjects/Keywords: adrenomedullin; angiotensin II; collagen XV; endothelin-1; hypertrophy; plasma membrane Ca<; sup>; 2+<; /sup>; -ATPase

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Piuhola, J. (. (2002). Regulation of cardiac responses to increased load:role of endothelin-1, angiotensin II and collagen XV. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9514267214

Chicago Manual of Style (16^th Edition):

Piuhola, J (Jarkko). “Regulation of cardiac responses to increased load:role of endothelin-1, angiotensin II and collagen XV.” 2002. Doctoral Dissertation, University of Oulu. Accessed March 01, 2021. http://urn.fi/urn:isbn:9514267214.

MLA Handbook (7^th Edition):

Piuhola, J (Jarkko). “Regulation of cardiac responses to increased load:role of endothelin-1, angiotensin II and collagen XV.” 2002. Web. 01 Mar 2021.

Vancouver:

Piuhola J(. Regulation of cardiac responses to increased load:role of endothelin-1, angiotensin II and collagen XV. [Internet] [Doctoral dissertation]. University of Oulu; 2002. [cited 2021 Mar 01]. Available from: http://urn.fi/urn:isbn:9514267214.

Council of Science Editors:

Piuhola J(. Regulation of cardiac responses to increased load:role of endothelin-1, angiotensin II and collagen XV. [Doctoral Dissertation]. University of Oulu; 2002. Available from: http://urn.fi/urn:isbn:9514267214

University of Cincinnati

10. BEAUMAN, SHIRELYN RAE. THE FUNCTION OF CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II IN CELL CYCLE REGULATION.

Degree: PhD, Medicine : Molecular and Cellular Physiology, 2003, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1054300335

► Ca ²⁺ /Calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is activated by increases in intracellular Ca ²⁺ . CaMKII is expressed in… (more)

▼ Ca ²⁺ /Calmodulin-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is activated by increases in intracellular Ca ²⁺ . CaMKII is expressed in all tissues but is most abundant in the brain. Diversity in subunit composition and Ca ²⁺ sensitivity permit the coordination of multiple cellular functions including muscle contraction, synaptic vesicle release, proliferation and differentiation. The factors allowing CaMKII to mediate a broad spectrum of cellular processes with such precision are just beginning to be understood. Proximity of Ca ²⁺ signals and the CaMKII activator Calmodulin (CaM), as well as CaMKII subunit composition influence the processes that CaMKII will mediate. As with other kinases, intracellular localization is thought to be a major factor in substrate selection. This dissertation presents two perspectives on CaMKII function. First, in light of the diversity and complexity of CaMKII function, investigation of compartmentalized CaMKII will provide more insight into the physiological condtions under which it operates. Targeted CaMKII genes also have the potential to be therapeutic agents. For example, CaMKII activates a chloride conductance at the plasma membrane of secretory epithelia. Plasma membrane targeted CaMKII may provide stimulation of this chloride channel that is adequate compensation for the defects in fluid secretion characteristic of cystic fibrosis (CF). CF is a lethal hereditary disease characterized by the accumulation of thick mucus secretions from polarized epithelial cells lining the airways and gastrointestinal tract, which impede organ function. The feasibility of targeting CaMKII to specific subcellular locations was investigated in HeLa cells with three CaMKII gene constructs each with a different plasma membrane targeting motif. The data show that plasma membrane targeting of CaMKII is feasible when the targeting motif is attached to the N-terminus of the protein, but not the C-terminus. The second part of this dissertation examines the role of CaMKII at the G2/M transition of the cell cycle. Previous reports show that CaMKII is required for progression from G2 into mitosis. Expression of autonomous CaMKII prevents this transition. Cell lines that display stable expression of an autonomous mutant CaMKII (CaMKIIT286D), reveal experience a delayed mitosis. It is likely that this delay is the result of autonomous CaMKII activation of a cell cycle checkpoint protein that impedes mitosis. Advisors/Committee Members: Dedman, Dr. John R. (Advisor).

Subjects/Keywords: CA <; sup>; 2+<; /sup>; /Calmodulin Dependent Protein Kinase II; Cyclin B1; subcellular localization; cell cycle; Targeting Motifs

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

BEAUMAN, S. R. (2003). THE FUNCTION OF CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II IN CELL CYCLE REGULATION. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1054300335

Chicago Manual of Style (16^th Edition):

BEAUMAN, SHIRELYN RAE. “THE FUNCTION OF CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II IN CELL CYCLE REGULATION.” 2003. Doctoral Dissertation, University of Cincinnati. Accessed March 01, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1054300335.

MLA Handbook (7^th Edition):

BEAUMAN, SHIRELYN RAE. “THE FUNCTION OF CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II IN CELL CYCLE REGULATION.” 2003. Web. 01 Mar 2021.

Vancouver:

BEAUMAN SR. THE FUNCTION OF CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II IN CELL CYCLE REGULATION. [Internet] [Doctoral dissertation]. University of Cincinnati; 2003. [cited 2021 Mar 01]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1054300335.

Council of Science Editors:

BEAUMAN SR. THE FUNCTION OF CALCIUM/CALMODULIN DEPENDENT PROTEIN KINASE II IN CELL CYCLE REGULATION. [Doctoral Dissertation]. University of Cincinnati; 2003. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1054300335

Freie Universität Berlin

11. Thul, Rüdiger. Das stochastische Medium Kalzium.

Degree: 2005, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-12612

► Im Zentrum dieser Arbeit steht ein einzelner Cluster aus Inositol-1,4,5-trisphosphat (IP3) Rezeptorkanälen (IP3Rs). Die fundamentale Bedeutung eines solchen Clusters beruht auf seiner Funktion in der… (more)

▼ Im Zentrum dieser Arbeit steht ein einzelner Cluster aus Inositol-1,4,5-trisphosphat (IP3) Rezeptorkanälen (IP3Rs). Die fundamentale Bedeutung eines solchen Clusters beruht auf seiner Funktion in der intrazellulären Signalweiterleitung. Er setzt Ca2+ aus intrazellulären Speichern wie dem endoplasmatischen Retikulum (ER) frei, wodurch eine Vielzahl von Prozessen reguliert wird. Dabei spielen sowohl hoch lokalisierte Elementarereignisse, sogenannte Puffs, als auch Ca2+ Wellen eine entscheidende Rolle. Während ein Ca2+ Puff nur einen einzelnen Cluster involviert, erstrecken sich Ca2+ Wellen auf Teile der Zelle oder sogar die gesamte Zelle. Wellen werden nur durch das koordinierte Zusammenspiel von mehreren Puffs ausgelöst. Daher stellt ein einzelner IP3R Cluster den gundlegenden Baustein für die durch IP3 vermittelte Ca2+ Dynamik dar. Im ersten Teil der Arbeit haben wir Ströme und Konzentrationsprofile simuliert, wie sie bei der Freisetzung von Ca2+ aus dem ER auftreten. Ein Cluster wurde als ein leitendes Loch in der Membran des ER mit einem Durchmesser von 6-36 nm beschrieben. Das endoplasmatische Retikulum wurde als eine Scheibe mit einem Radius von 1-12μm und einer inneren Höhe von 28nm modeliert. Wir haben die Abhängigkeit der Ströme von der Ca2+ Konzentration im ER, wie sie in Versuchen mit Lipid-Doppelschichten gemessen worden ist, an die zelluläre Geometrie angepaßt. Die simulierten Ströme stimmen sehr gut mit Messungen der Signalmasse in Xenopus Oozyten überein. Die Abhängigkeit der Ströme von der Ca2+ Konzentration im ER stellte sich als linear heraus. Weiterhin ergab sich, daß die Ströme ungefähr proportional zu der Wurzel aus der Anzahl der offenen Kanäle in einem Cluster sind. Die zytosolischen Ca2+ Konzentrationen an einem offenen Cluster erreichten Werte von 25-170μM. Der Anstieg der Ca2+ Konzentration in einer Entfernung von einigen Mikrometern von einem offenen Cluster war im Bereich von einigen Nanomolar. Die Ströme zerfielen biexponential mit Zeitskalen von weniger als 1 Sekunde sowie mehreren Sekunden. Konzentrationsprofile hingegen zerfielen mit Zeitskalen von 0.125-0.250s nach Beendigung der Freisetzung. Um die Konsequenzen zu untersuchen, die sich aus der stark lokalisierten Ca2+ Freisetzung in einem deterministischen Modell ergeben, haben wir einen neuen Ansatz zur Beschreibung der Reaktions-Diffusions-Dynamik zwischen diffundierenden Molekülen und räumlich fixierten Reaktionspartnern entwickelt. Die immobilen Reaktanten bildeten Cluster, die aus nur wenigen Molekülen bestehen. Diese Moleküle nahmen nur dann an der Reaktion teil, wenn sie aktiviert wurden. Wir haben diese Aktivierungsdynamik auf die zeitabhängige Ausdehnung eines aktiven Gebietes innerhalb des Clusters abgebildet. Eine lineare Stabilitätsanalyse zeigte, daß die Diffusion die Stabilität der Dynamik entscheidend bestimmte. Angewandt auf die Ca2+ Dynamik ergab sich, daß die hohen lokalen Ca2+ Konzentrationen die Rückkopplungsmechanismen sättigen, die für die Kontrolle der Zustände der IP3 Rezeptorkanäle verantwortlich sind. Das… Advisors/Committee Members: n (gender), Prof. Dr. Erwin Frey (firstReferee), Prof. Dr. Lutz Schimansky-Geier (furtherReferee).

Subjects/Keywords: intracellular Ca<; sup>; 2+<; /sup>; dynamics; Ca<; sup>; 2+<; /sup>; puffs; IP<; sub>; 3<; /sub>; receptor channel cluster; stochastic dynamics; 87.16.Ac; 05.40.-a; 500 Naturwissenschaften und Mathematik::530 Physik::530 Physik

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Thul, R. (2005). Das stochastische Medium Kalzium. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-12612

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Thul, Rüdiger. “Das stochastische Medium Kalzium.” 2005. Thesis, Freie Universität Berlin. Accessed March 01, 2021. http://dx.doi.org/10.17169/refubium-12612.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Thul, Rüdiger. “Das stochastische Medium Kalzium.” 2005. Web. 01 Mar 2021.

Vancouver:

Thul R. Das stochastische Medium Kalzium. [Internet] [Thesis]. Freie Universität Berlin; 2005. [cited 2021 Mar 01]. Available from: http://dx.doi.org/10.17169/refubium-12612.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Thul R. Das stochastische Medium Kalzium. [Thesis]. Freie Universität Berlin; 2005. Available from: http://dx.doi.org/10.17169/refubium-12612

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Pretoria

12. [No author]. Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans) .

Degree: 2007, University of Pretoria

URL: http://upetd.up.ac.za/thesis/available/etd-03232006-171834/

No Abstract is provided. Advisors/Committee Members: Prof J G Van der Watt (advisor).

Subjects/Keywords: Church biblical teaching; Community biblical teaching; Church history primitive and early church ca 30-60; UCTD

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

author], [. (2007). Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans) . (Doctoral Dissertation). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-03232006-171834/

Chicago Manual of Style (16^th Edition):

author], [No. “Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans) .” 2007. Doctoral Dissertation, University of Pretoria. Accessed March 01, 2021. http://upetd.up.ac.za/thesis/available/etd-03232006-171834/.

MLA Handbook (7^th Edition):

author], [No. “Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans) .” 2007. Web. 01 Mar 2021.

Vancouver:

author] [. Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans) . [Internet] [Doctoral dissertation]. University of Pretoria; 2007. [cited 2021 Mar 01]. Available from: http://upetd.up.ac.za/thesis/available/etd-03232006-171834/.

Council of Science Editors:

author] [. Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans) . [Doctoral Dissertation]. University of Pretoria; 2007. Available from: http://upetd.up.ac.za/thesis/available/etd-03232006-171834/

University of Pretoria

13. Potgieter, Salomon Theodorus. Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans).

Degree: New Testament Studies, 2007, University of Pretoria

URL: http://hdl.handle.net/2263/23390

No Abstract is provided. Advisors/Committee Members: Prof J G Van der Watt (advisor).

Subjects/Keywords: Church biblical teaching; Community biblical teaching; Church history primitive and early church ca 30-60; UCTD

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Potgieter, S. (2007). Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans). (Doctoral Dissertation). University of Pretoria. Retrieved from http://hdl.handle.net/2263/23390

Chicago Manual of Style (16^th Edition):

Potgieter, Salomon. “Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans).” 2007. Doctoral Dissertation, University of Pretoria. Accessed March 01, 2021. http://hdl.handle.net/2263/23390.

MLA Handbook (7^th Edition):

Potgieter, Salomon. “Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans).” 2007. Web. 01 Mar 2021.

Vancouver:

Potgieter S. Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans). [Internet] [Doctoral dissertation]. University of Pretoria; 2007. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2263/23390.

Council of Science Editors:

Potgieter S. Ekklesiologiese perspektiewe volgens die Evangelie van Johannes : 'n eksegeties-teologiese ondersoek (Afrikaans). [Doctoral Dissertation]. University of Pretoria; 2007. Available from: http://hdl.handle.net/2263/23390

Freie Universität Berlin

14. Hohaus, Annette. Interactions of the Ca2+ channel β2 subunit with the ion-conducting α1C subunit and the giant protein Ahnak: Functional analysis and characterization of binding domains.

Degree: 2002, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-5284

► L-type Ca2+channels are protein complexes that play a critical role in the regulation of muscle contractility. Gating as well as regulation of voltage- dependent Ca2+channels… (more)

▼ L-type Ca2+channels are protein complexes that play a critical role in the regulation of muscle contractility. Gating as well as regulation of voltage- dependent Ca2+channels is for a large part determined by the interaction between ion-conducting a 1 and b subunits. An aim of this study was to analyze modulation of the smooth-muscle Ca2+channel a 1C-b subunit by the accessory b 2a subunit at single-channel level. In addition, the functional role of the a 1-b interaction was studied using an synthetic peptide (AID-peptide) that corresponds to the sequence of the a 1 interaction domain (AID). Ca2+ channels derived by coexpression of a 1C-b and b 2a subunits in HEK cells exhibited a significantly higher open probability (Po) than a 1C-b channels. High Po gating of a 1C-b·b 2a channels was associated with promotion of long-lasting openings (t >10ms). Binding experiments with the AID-peptide showed a specific affinity to the native b 2 subunit. Administration of the AID-peptide to the cytoplasmic side of inside- out patches induced a rapid decline of Po of a 1C-b·b 2 channels. The AID- peptide did not modify a 1C-b channel function in absence of expressed b 2a subunit, and the scrambled control peptide failed to affect a 1C-b ·b 2a channels. The results demonstrate that the b 2 subunit controls fast gating of a 1C-b channels, and suggest the a 1-b interaction domain as a possible target of modulation of the channel. Recently it was shown that ahnak, a 700 kDa phosphoprotein, is linked to cardiac L-type Ca2+ channel via the b 2 subunit by coprecipitation experiments. So far, the molecular details of this interaction has not been studied. Herein, the interaction was defined between b 2 subunit and ahnak. Overlay binding assays as well as sedimantation equilibrium analysis with glutathione-S-transferase fusion proteins revealed specific, high-affinity b 2a binding for the most C-terminal region of ahnak (ahnak-C2, aa 5262-5643). Within the b 2a protein, two binding sites for ahnak-C2 with differing affinities (Kd1=53 nM, Kd2=212 nM) were determined. The high affinity site localizes in the C-terminal (aa 195-606, Kd=55 nM) b 2a portion, while the binding site of lower affinity resides in the N-terminal (aa 1-200, Kd=328 nM) portion of b 2a subunit. Protein-protein interaction between ahnak-C2 and b subunits was corroborated by in vitro pull-down assay with native Ca2+ channels, since ahnak-C2 affinity beads recovered cardiac b 2 subunits and skeletal muscle b 1a subunits together with the corresponding a 1C and a 1S proteins. These results underline the significance of b subunits in tethering the a 1 subunit of L-type Ca2+ channels to ahnak. Advisors/Committee Members: n (gender), Prof. Dr. Hanno Dieter Schmidt (firstReferee), Priv.-Doz. Dr. Timothy D. Plant (furtherReferee).

Subjects/Keywords: Ca<; sup>; 2+<; /sup>; channel, β 2 subunit, α 1C-β interaction, AID, Ahnak; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hohaus, A. (2002). Interactions of the Ca2+ channel β2 subunit with the ion-conducting α1C subunit and the giant protein Ahnak: Functional analysis and characterization of binding domains. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-5284

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hohaus, Annette. “Interactions of the Ca2+ channel β2 subunit with the ion-conducting α1C subunit and the giant protein Ahnak: Functional analysis and characterization of binding domains.” 2002. Thesis, Freie Universität Berlin. Accessed March 01, 2021. http://dx.doi.org/10.17169/refubium-5284.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hohaus, Annette. “Interactions of the Ca2+ channel β2 subunit with the ion-conducting α1C subunit and the giant protein Ahnak: Functional analysis and characterization of binding domains.” 2002. Web. 01 Mar 2021.

Vancouver:

Hohaus A. Interactions of the Ca2+ channel β2 subunit with the ion-conducting α1C subunit and the giant protein Ahnak: Functional analysis and characterization of binding domains. [Internet] [Thesis]. Freie Universität Berlin; 2002. [cited 2021 Mar 01]. Available from: http://dx.doi.org/10.17169/refubium-5284.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hohaus A. Interactions of the Ca2+ channel β2 subunit with the ion-conducting α1C subunit and the giant protein Ahnak: Functional analysis and characterization of binding domains. [Thesis]. Freie Universität Berlin; 2002. Available from: http://dx.doi.org/10.17169/refubium-5284

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Wang, Tingting. Molecular Regulation of Inducible Nitric Oxide Synthase.

Degree: PhD, Biochemistry Program, Ohio State, 2012, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1353684453

► Nitric oxide (NO) generated by inducible NO synthase (iNOS) plays critical roles in inflammation and host defense. iNOS expression is induced by inflammatory stimuli… (more)

▼ Nitric oxide (NO) generated by inducible NO synthase (iNOS) plays critical roles in inflammation and host defense. iNOS expression is induced by inflammatory stimuli and exhibits constant activity once expressed. Hence NO production from iNOS has been thought to be primarily controlled via enzyme expression. In this study, we identify an array of novel mechanisms showing that iNOS is regulated at multiple levels including gene expression, protein aggregation, and protein degradation. Calmodulin (CaM) has always been thought as an iNOS cofactor facilitating electron transfer amid NO syntheses. We now show that CaM is essential for iNOS induction. CaM inhibition or knockdown prevented iNOS expressions in macrophages stimulated by inflammatory mediators. Further studies revealed that CaM acted through Ca²⁺/CaM-dependent kinase II (CaMKII), which functioned as a cardinal initiator in iNOS gene transactivation via both LPS-NF-¿¿¿¿¿B and IFN-γ-STAT1 pathways. Our study also found that iNOS gene transactivation required cytosolic Ca²⁺ elevations. CaM or CaMKII inhibition was found to prevent iNOS induction in endotoxemic mice and improved survival rates. These studies extend the role of CaM from an enzyme cofactor to an essential modulator in iNOS gene transactivation. Once expressed, biological iNOS output is determined by the levels of functional enzyme, which is influenced by protein stability. Our studies found that while initially existing as a soluble protein, iNOS progressively formed inactive protein aggregates. Blocking NO production prevented iNOS aggregation inside cells. iNOS aggresome formation could be recaptured by exposing cells to exogenous NO. The finding that NO per se induces iNOS aggregation and inactivation suggests aggresome formation as a feedback inhibition mechanism in iNOS regulation. After elucidating NO-mediated iNOS aggregation in physiological conditions, we then investigated iNOS protein stability under pathological circumstances upon heat shock protein 90 (Hsp90) or CaM inhibition. Hsp90 was previously reported to play an important role in iNOS function and gene expression. We now find that dissociation of Hsp90 from iNOS led to iNOS aggregation and these aggregates were cleared by ubiquitin-proteasome system. Further studies revealed that the SPRY domain-containing SOCS box protein 2 (SPSB2), but not the C-terminus of heat shock protein 70-interacting protein (CHIP), was essential for aggregated iNOS turnover in Hsp90-inhibited cells. Our studies found that CaM inhibition disrupted CaM-iNOS interaction, exposing the hydrophobic CaM-binding domain on iNOS which mediated iNOS aggregation. These studies identified novel roles of Hsp90 and CaM in modulating iNOS protein stability. To gain a complete understanding of iNOS regulation, we investigated the ubiquitination site responsible for proteasomal degradation of iNOS. The N-terminal 1-100 amino acids were found to be essential for iNOS degradation. However, arginine replacement of all… Advisors/Committee Members: Xia, Yong (Advisor).

Subjects/Keywords: Biochemistry; Biology; Biomedical Research; Cellular Biology; Molecular Biology; iNOS; CaM; CaMKII; Ca<; sup>; 2+<; /sup>;

…60). Previous studies conducted by Eissa group reported that UPS route is the major…

10 more images…

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, T. (2012). Molecular Regulation of Inducible Nitric Oxide Synthase. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1353684453

Chicago Manual of Style (16^th Edition):

Wang, Tingting. “Molecular Regulation of Inducible Nitric Oxide Synthase.” 2012. Doctoral Dissertation, The Ohio State University. Accessed March 01, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1353684453.

MLA Handbook (7^th Edition):

Wang, Tingting. “Molecular Regulation of Inducible Nitric Oxide Synthase.” 2012. Web. 01 Mar 2021.

Vancouver:

Wang T. Molecular Regulation of Inducible Nitric Oxide Synthase. [Internet] [Doctoral dissertation]. The Ohio State University; 2012. [cited 2021 Mar 01]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1353684453.

Council of Science Editors:

Wang T. Molecular Regulation of Inducible Nitric Oxide Synthase. [Doctoral Dissertation]. The Ohio State University; 2012. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1353684453

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations