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Universiteit Utrecht
1.
Sinsai, J.B.
Diet and COPD: How have recent epidemiological studies added to the current knowledge on this association?.
Degree: 2011, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/205251 
► Summary: Previously, the importance of a diet-COPD relationship has been recognised in epidemiological research. However, several uncertainties, including residual confounding by smoking and assessment of…
(more)
▼ Summary:
Previously, the importance of a diet-
COPD relationship has been recognised in epidemiological research. However, several uncertainties, including residual confounding by smoking and assessment of a temporal diet-
COPD relationship, have previously been highlighted [5]. In the recent 5 years, there has been a shift to dietary pattern assessments and their implications on lung function and
COPD. These recent studies have added knowledge to the current evidence on diet and
COPD, particularly in their explorations of dietary patterns and combined food effects, as opposed to assessments of individual foods and nutrients. Additionally, evidence has suggested that a ‘healthy’ diet such as the ‘prudent’ diet may have beneficial implications on
COPD [16, 17, 19]. These conclusions are in light with the globally recognised importance of healthy eating, and in essence, have important implications on public health. However, no studies to date have investigated the temporality of this association and to what extent smoking modifies this association. As a result, the interpretation of current evidence is not sufficient to establish causality in the association between diet and
COPD. The current challenge is to prospectively identify the role of smoking on this relationship by comparing smokers and non-smokers. Moreover, future studies are needed to elucidate on the impact of diet on the development and course of
COPD. This will allow us to definitively establish causality, and in essence will have important implications for further public health research.
Advisors/Committee Members: Smit, H.A..
Subjects/Keywords: Diet; COPD
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APA (6th Edition):
Sinsai, J. B. (2011). Diet and COPD: How have recent epidemiological studies added to the current knowledge on this association?. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/205251
Chicago Manual of Style (16th Edition):
Sinsai, J B. “Diet and COPD: How have recent epidemiological studies added to the current knowledge on this association?.” 2011. Masters Thesis, Universiteit Utrecht. Accessed February 26, 2021.
http://dspace.library.uu.nl:8080/handle/1874/205251.
MLA Handbook (7th Edition):
Sinsai, J B. “Diet and COPD: How have recent epidemiological studies added to the current knowledge on this association?.” 2011. Web. 26 Feb 2021.
Vancouver:
Sinsai JB. Diet and COPD: How have recent epidemiological studies added to the current knowledge on this association?. [Internet] [Masters thesis]. Universiteit Utrecht; 2011. [cited 2021 Feb 26].
Available from: http://dspace.library.uu.nl:8080/handle/1874/205251.
Council of Science Editors:
Sinsai JB. Diet and COPD: How have recent epidemiological studies added to the current knowledge on this association?. [Masters Thesis]. Universiteit Utrecht; 2011. Available from: http://dspace.library.uu.nl:8080/handle/1874/205251
University of Utah
2.
Rossman, Matthew J.
The impact of oxidative stress on oxygen transport and utilization in health and disease.
Degree: PhD, Exercise & Sport Science, 2015, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3852/rec/2556
► The overall objective of this dissertation was to examine the impact of oxidative stress on oxygen transport and utilization, and ultimately physiological function, in older…
(more)
▼ The overall objective of this dissertation was to examine the impact of oxidative stress on oxygen transport and utilization, and ultimately physiological function, in older individuals and patients with chronic obstructive pulmonary disease (COPD). The goal of the first study was to better understand the age-associated attenuation in leg blood flow (LBF), with a focus on the role of redox balance, at rest and during exercise. Under control conditions, by experimental design, aging was associated with ~15% reduction in LBF. During knee extensor exercise (KE), the old also exhibited greater leg free radical outflow, assessed by electron paramagnetic resonance (EPR) spectroscopy, than the young. At rest, administration of an acute, oral antioxidant cocktail (AOC) increased antioxidant capacity, decreased the EPR signal, and consequently, restored LBF in the old such that it was not different from the young. During exercise, however, the AOC did not alter free radical outflow from the muscle or LBF. Thus, these data document exaggerated free radical production during exercise in older individuals exhibiting attenuated LBF, and identify a favorable effect of decreasing oxidative stress on resting hemodynamics in these individuals. However, the inability of the oral AOC to alter free radical outflow or LBF during exercise suggests that the formidable, pro-oxidant state elicited by exercise in the old likely necessitates a more potent antioxidant strategy to alter free radical outflow and potentially improve LBF in this population. The second study sought to determine the impact of acute, oral AOC administration on oxygen transport and utilization in a population recognized to have elevated oxidative stress, patients with chronic obstructive pulmonary disease (COPD). AOC administration led to an improvement in LBF during submaximal KE exercise, which was accompanied by an increase in muscle oxygen consumption, in the patients with COPD, but minimal effects in healthy subjects. Additionally, arterial oxygen saturation was improved in the patients with COPD, but unaltered in the healthy subjects. These results reveal detrimental consequences of elevated oxidative stress in patients with COPD in terms of vascular control, and oxygen transport and utilization during exercise. The third study examined the functional consequences of reducing oxidative stress in patients with COPD in terms of skeletal muscle fatigue development. Following intravenous ascorbate administration, an overall attenuation in the ventilatory and metabolic responses to high-intensity KE performed for the same duration and at the same intensity as the placebo condition was observed. Additionally, following the exercise matched for time, the patients exhibited less peripheral quadriceps fatigue. These results suggest a beneficial role for antioxidant administration in COPD, and further implicate oxidative stress in the systemic, pathophysiological consequences of the condition. Collectively, this research has identified novel, biological mechanisms by which…
Subjects/Keywords: COPD; exercise
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APA (6th Edition):
Rossman, M. J. (2015). The impact of oxidative stress on oxygen transport and utilization in health and disease. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3852/rec/2556
Chicago Manual of Style (16th Edition):
Rossman, Matthew J. “The impact of oxidative stress on oxygen transport and utilization in health and disease.” 2015. Doctoral Dissertation, University of Utah. Accessed February 26, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3852/rec/2556.
MLA Handbook (7th Edition):
Rossman, Matthew J. “The impact of oxidative stress on oxygen transport and utilization in health and disease.” 2015. Web. 26 Feb 2021.
Vancouver:
Rossman MJ. The impact of oxidative stress on oxygen transport and utilization in health and disease. [Internet] [Doctoral dissertation]. University of Utah; 2015. [cited 2021 Feb 26].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3852/rec/2556.
Council of Science Editors:
Rossman MJ. The impact of oxidative stress on oxygen transport and utilization in health and disease. [Doctoral Dissertation]. University of Utah; 2015. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3852/rec/2556
3.
Juneau, Richard Anthony.
Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress.
Degree: 2011, Wake Forest University
URL: http://hdl.handle.net/10339/36165
► Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative commensal bacteria of the human nasopharynx. Normally residing in healthy individuals, NTHi rarely causes adverse effects. However, infection…
(more)
▼ Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative commensal bacteria of the human nasopharynx. Normally residing in healthy individuals, NTHi rarely causes adverse effects. However, infection with NTHi in children often leads to middle ear inflammation and disease in the form of otitis media. A high frequency of doctor visits, antibiotic prescription, and drainage tube placement are due to childhood otitis media infections. Chronic obstructive pulmonary disease (COPD) is a restriction of airflow through the lungs and is often caused by cigarette smoking. In the United States, COPD is the fourth leading cause of death. NTHi is often found in patients suffering from COPD and it is implicated in exacerbation of disease. Since these diseases remain a health-care concern, it is important that we continue to study NTHi disease dynamics and host responses during the disease.
Subjects/Keywords: COPD
…172
vii
LIST OF TABLES
Page
Table 1. Potential Bacterial Contributions to COPD… …Haemophilus influenzae
OM
Otitis media
COPD
Chronic obstructive pulmonary disease
NET(s… …x28;COPD) is a restriction of airflow through the lungs and is often
caused by… …cigarette smoking. In the United States, COPD is the fourth leading
cause of death.
NTHi is often… …found in patients suffering from COPD and it is
implicated in exacerbation of disease. Since…
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APA (6th Edition):
Juneau, R. A. (2011). Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/36165
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Juneau, Richard Anthony. “Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress.” 2011. Thesis, Wake Forest University. Accessed February 26, 2021.
http://hdl.handle.net/10339/36165.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Juneau, Richard Anthony. “Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress.” 2011. Web. 26 Feb 2021.
Vancouver:
Juneau RA. Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress. [Internet] [Thesis]. Wake Forest University; 2011. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10339/36165.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Juneau RA. Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress. [Thesis]. Wake Forest University; 2011. Available from: http://hdl.handle.net/10339/36165
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Debrecen
4.
Jeges, Alexandra.
A PPARy génben található öt genetikai polimorfizmus és a krónikus obstruktív tüdőbetegség kialakulása közötti asszociáció vizsgálata
.
Degree: DE – TEK – Természettudományi és Technológiai Kar – Biológiai és Ökológiai Intézet, 2011, University of Debrecen
URL: http://hdl.handle.net/2437/105781
► A krónikus obstruktív tüdőbetegség (COPD) kialakulásának kockázatát befolyásoló genetikai polimorfizmusok vizsgálata egy a magyar népességből vett mintában. Munkánk során azt vizsgáltuk, hogy a biológiai funkciója…
(more)
▼ A krónikus obstruktív tüdőbetegség (
COPD) kialakulásának kockázatát befolyásoló genetikai polimorfizmusok vizsgálata egy a magyar népességből vett mintában. Munkánk során azt vizsgáltuk, hogy a biológiai funkciója alapján a
COPD feltételezett patomechanizmusában szerintünk szerepet játszó, általunk hajlamosító génnek feltételezett PPAR génben található SNP-k befolyásolják-e a
COPD kialakulásának valószínűségét.
Advisors/Committee Members: Penyige, András (advisor).
Subjects/Keywords: COPD;
Tüdőbetegség
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APA (6th Edition):
Jeges, A. (2011). A PPARy génben található öt genetikai polimorfizmus és a krónikus obstruktív tüdőbetegség kialakulása közötti asszociáció vizsgálata
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/105781
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Jeges, Alexandra. “A PPARy génben található öt genetikai polimorfizmus és a krónikus obstruktív tüdőbetegség kialakulása közötti asszociáció vizsgálata
.” 2011. Thesis, University of Debrecen. Accessed February 26, 2021.
http://hdl.handle.net/2437/105781.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Jeges, Alexandra. “A PPARy génben található öt genetikai polimorfizmus és a krónikus obstruktív tüdőbetegség kialakulása közötti asszociáció vizsgálata
.” 2011. Web. 26 Feb 2021.
Vancouver:
Jeges A. A PPARy génben található öt genetikai polimorfizmus és a krónikus obstruktív tüdőbetegség kialakulása közötti asszociáció vizsgálata
. [Internet] [Thesis]. University of Debrecen; 2011. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/2437/105781.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Jeges A. A PPARy génben található öt genetikai polimorfizmus és a krónikus obstruktív tüdőbetegség kialakulása közötti asszociáció vizsgálata
. [Thesis]. University of Debrecen; 2011. Available from: http://hdl.handle.net/2437/105781
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Debrecen
5.
Antal, Pálné.
COPD, "Az alattomos gyilkos"
.
Degree: DE – Egészségügyi Kar, University of Debrecen
URL: http://hdl.handle.net/2437/208921
Subjects/Keywords: COPD
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Manager
APA (6th Edition):
Antal, P. (n.d.). COPD, "Az alattomos gyilkos"
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/208921
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Antal, Pálné. “COPD, "Az alattomos gyilkos"
.” Thesis, University of Debrecen. Accessed February 26, 2021.
http://hdl.handle.net/2437/208921.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Antal, Pálné. “COPD, "Az alattomos gyilkos"
.” Web. 26 Feb 2021.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
Antal P. COPD, "Az alattomos gyilkos"
. [Internet] [Thesis]. University of Debrecen; [cited 2021 Feb 26].
Available from: http://hdl.handle.net/2437/208921.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Council of Science Editors:
Antal P. COPD, "Az alattomos gyilkos"
. [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/208921
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
University of Manitoba
6.
Tripathi, Soma.
Reduced proliferation and increased TSLP expression by lung fibroblasts from COPD patients.
Degree: Physiology, 2014, University of Manitoba
URL: http://hdl.handle.net/1993/23212
► Chronic obstructive pulmonary disease (COPD) is identified with partially reversible airflow limitation, chronic bronchitis, small airway remodelling, and alveolar destruction. COPD is also progressive in…
(more)
▼ Chronic obstructive pulmonary disease (
COPD) is identified with partially reversible airflow limitation, chronic bronchitis, small airway remodelling, and alveolar destruction.
COPD is also progressive in nature. TSLP (Thymic stromal lymphopoietin), an Interleukin (IL)-7 like cytokine expressed by structural cells, is a determinant of inflammation. We aimed to characterize human lung fibroblasts (HLF) from human donors with
COPD as well as patients without
COPD (non-
COPD), comparing proliferation and TSLP release. Statins can exert anti-proliferative and anti-inflammatory effects, and their use has been linked to improved lung health, thus we also examined the effect of statins on proliferation and cytokine release by lung fibroblasts from
COPD and non-
COPD donors. Primary HLF cultures from three
COPD diagnosed and non-
COPD donors were used. Proliferation was measured using laser scanning cytometry (LSC) counting of H33248-stained cells with 5% fetal bovine along with the addition of simvastatin (0.1µM and 0.5µM). TNFα (tumor necrosis factor α) and/or IL-1β (interleukin 1β) (10ng/mL), and various concentrations of cigarette smoke extract (CSE) were used to stimulate cells. TSLP release, mRNA abundance and transcriptional activity were measured by ELISA, Real Time Polymerase Chain Recation (RT- PCR) and luciferase assay, respectively. RT-PCR was also utilized to profile TNFα and Interleukin 1β receptors. We also ascertained the effect of various stimuli on receptor-mediated signaling pathways using Western blotting. Impact of simvastatin (1-10µM) on TSLP release was determined by ELISA.
During exponential growth phase, HLF from
COPD donors proliferated 46.7% slower than from non-
COPD. Simvastatin (0.5µM) inhibited proliferation, as indicated by 53% (P<0.01) and 48% (P< 0.001) fewer
COPD and non-
COPD donor HLFs at Day 6 culture. At baseline
COPD HLFs make approximately 2-fold (P<0.05) more TSLP/cell compared to non-
COPD HLFs. TNFα and/or IL-1β (10ng/ml, 48h) induced approximately 1.8 to 2.3-fold (P<0.05) more TSLP release in
COPD HLFs. Interestingly, simvastatin had no impact on basal TSLP release, but in the presence of TNFα (5µM, 72h), TSLP release was actually increased approximately 2.19-fold (
COPD) and 1.8-fold (non-
COPD). TSLP mRNA levels were maximum at 6h in both
COPD and non-
COPD HLFs and relative TSLP mRNA was approximately 15-fold higher in
COPD HLFs compared to non-
COPD HLFs (P<0.01). This correlated with human TSLP promoter luciferase reporter assays that showed baseline transcription in
COPD HLFs is markedly (approximately 17-fold) higher than non-
COPD HLFs. In TNFα-stimulated cultures, TSLP luciferase activity was approximately 10-fold higher in
COPD HLFs compared to HLFs from non-
COPD. There was no difference in mRNA abundance of receptor subunits for TNFα or IL-1β between patient groups. Phosphorylation of mitogen activated protein kinases, ERK1/2 and p38MAPK, were also comparatively higher in
COPD HLFs when stimulated with TNFα suggesting increased response via TNFα receptors. Additionally, in…
Advisors/Committee Members: Halayko, Andrew J (Physiology) (supervisor), Dakshinamurti, Shyamala (Physiology) Zahradka, Peter (Physiology) Uzonna, Jude (Immunology) (examiningcommittee).
Subjects/Keywords: COPD; TSLP
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APA (6th Edition):
Tripathi, S. (2014). Reduced proliferation and increased TSLP expression by lung fibroblasts from COPD patients. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/23212
Chicago Manual of Style (16th Edition):
Tripathi, Soma. “Reduced proliferation and increased TSLP expression by lung fibroblasts from COPD patients.” 2014. Masters Thesis, University of Manitoba. Accessed February 26, 2021.
http://hdl.handle.net/1993/23212.
MLA Handbook (7th Edition):
Tripathi, Soma. “Reduced proliferation and increased TSLP expression by lung fibroblasts from COPD patients.” 2014. Web. 26 Feb 2021.
Vancouver:
Tripathi S. Reduced proliferation and increased TSLP expression by lung fibroblasts from COPD patients. [Internet] [Masters thesis]. University of Manitoba; 2014. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1993/23212.
Council of Science Editors:
Tripathi S. Reduced proliferation and increased TSLP expression by lung fibroblasts from COPD patients. [Masters Thesis]. University of Manitoba; 2014. Available from: http://hdl.handle.net/1993/23212
University of Debrecen
7.
Saggar, Navdeep.
Radiological aspects of chronic obstructive pulmonary disease
.
Degree: DE – Általános Orvostudományi Kar, University of Debrecen
URL: http://hdl.handle.net/2437/195475
Subjects/Keywords: COPD;
CT COPD
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APA ·
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Manager
APA (6th Edition):
Saggar, N. (n.d.). Radiological aspects of chronic obstructive pulmonary disease
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/195475
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Saggar, Navdeep. “Radiological aspects of chronic obstructive pulmonary disease
.” Thesis, University of Debrecen. Accessed February 26, 2021.
http://hdl.handle.net/2437/195475.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Saggar, Navdeep. “Radiological aspects of chronic obstructive pulmonary disease
.” Web. 26 Feb 2021.
Note: this citation may be lacking information needed for this citation format:
No year of publication.
Vancouver:
Saggar N. Radiological aspects of chronic obstructive pulmonary disease
. [Internet] [Thesis]. University of Debrecen; [cited 2021 Feb 26].
Available from: http://hdl.handle.net/2437/195475.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
Council of Science Editors:
Saggar N. Radiological aspects of chronic obstructive pulmonary disease
. [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/195475
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.
McMaster University
8.
McLay, Rachel.
Validating Short Balance Screening Tests for Assessing Fall Risk in People with Chronic Obstructive Pulmonary Disease (COPD).
Degree: MSc, 2019, McMaster University
URL: http://hdl.handle.net/11375/24736
► Background: People with COPD have significant balance impairments and an increased risk of falls. The psychometric properties of short balance screening tests to inform fall…
(more)
▼ Background: People with COPD have significant balance impairments and an increased risk of falls. The psychometric properties of short balance screening tests to inform fall risk assessment in COPD have not been studied. The objective of this study was to compare the validity of four short balance tests suitable for fall risk screening to identify the most optimal screening tool(s).
Methods: Participants at least 60 years old with COPD attended a single physical assessment with completion of questionnaires. Correlation coefficients were used to describe relationships between the Brief Balance Evaluation Systems Test (Brief BESTest), Single-Leg Stance (SLS), Timed Up and Go (TUG) and Timed Up and Go Dual-Task (TUG-DT) tests, and other measures of balance, measures of muscle strength, exercise tolerance, functional limitation, disability and prognosis. Independent t-tests or Mann-Whitney U tests were used to examine differences between groups with respect to fall risk. Receiver operating characteristic curves were plotted to examine the ability to of the screening tests to identify individuals with previous falls.
Results: Seventy-three participants with COPD completed the study (age 73.0 ± 6.9 years; FEV1 47.0 ± 19.8% predicted). All balance screening tests demonstrated moderate to strong correlations with the Berg Balance Scale (r= 0.47 to 0.80, p<0.05) and Activities-specific Balance Confidence scale (r= 0.44 to 0.61, p<0.05). The Brief BESTest and SLS showed the strongest correlations with other balance measures and demonstrated the most consistent ability to discriminate between fall risk groups. The
Brief BESTest was the only screening test that identified individuals who reported a previous fall with acceptable accuracy (AUC= 0.7).
Conclusions: The Brief BESTest and SLS show the most promise as balance screening tools for fall risk assessment in older adults with COPD. These results will need to be prospectively confirmed with a larger sample size.
Thesis
Master of Science Rehabilitation Science (MSc)
Advisors/Committee Members: Beauchamp, Marla, Rehabilitation Science.
Subjects/Keywords: Balance; Falls; COPD
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APA ·
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Manager
APA (6th Edition):
McLay, R. (2019). Validating Short Balance Screening Tests for Assessing Fall Risk in People with Chronic Obstructive Pulmonary Disease (COPD). (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/24736
Chicago Manual of Style (16th Edition):
McLay, Rachel. “Validating Short Balance Screening Tests for Assessing Fall Risk in People with Chronic Obstructive Pulmonary Disease (COPD).” 2019. Masters Thesis, McMaster University. Accessed February 26, 2021.
http://hdl.handle.net/11375/24736.
MLA Handbook (7th Edition):
McLay, Rachel. “Validating Short Balance Screening Tests for Assessing Fall Risk in People with Chronic Obstructive Pulmonary Disease (COPD).” 2019. Web. 26 Feb 2021.
Vancouver:
McLay R. Validating Short Balance Screening Tests for Assessing Fall Risk in People with Chronic Obstructive Pulmonary Disease (COPD). [Internet] [Masters thesis]. McMaster University; 2019. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/11375/24736.
Council of Science Editors:
McLay R. Validating Short Balance Screening Tests for Assessing Fall Risk in People with Chronic Obstructive Pulmonary Disease (COPD). [Masters Thesis]. McMaster University; 2019. Available from: http://hdl.handle.net/11375/24736
University of Newcastle
9.
Warsanah, Irwan Hanish bin.
Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases.
Degree: PhD, 2015, University of Newcastle
URL: http://hdl.handle.net/1959.13/1305657
► Research Doctorate - Doctor of Philosophy (PhD)
Influenza infections are of major importance as they have a significant impact on the health of individuals and…
(more)
▼ Research Doctorate - Doctor of Philosophy (PhD)
Influenza infections are of major importance as they have a significant impact on the health of individuals and impart substantial socio-economic ramifications on society. Prevention and treatment of influenza infections are complicated by frequent genetic mutations of the influenza virus. Patients with underlying chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and asthma are more susceptible to influenza infection, and infection with influenza exacerbates these diseases. Therefore, elucidation of the mechanisms underpinning increased susceptibility to influenza in these patients is vital. Here, we established an experimental mouse model of COPD and utilised an existing ovalbumin-induced allergic airways disease (AAD) model to investigate the effects of influenza infection in COPD and asthma, respectively. Influenza infection in experimental COPD resulted in increased viral titre, exaggerated airway inflammation and further impaired lung function. These effects were accompanied by decreased neutrophil influx into the airways, reduced antiviral interferon responses, and the suppression of a range of cytokines and chemokines, including interferon (IFN)-γ, tumour necrosis factor (TNF)-α, IFN-γ-induced protein (IP)-10, macrophage inflammatory protein (MIP)-1α, keratinocyte-derived chemokine (KC, or IL-8 in humans) and interleukin (IL)-10, as well as increased IL-6. This increased susceptibility was mediated by an increase in phosphoinositide 3-kinase (PI3K) protein expression. The inhibition of PI3K effectively reduced viral titre, enhanced antiviral IFNs and improved lung function. Influenza infection in recombinant IL-13-treated or ovalbumin (Ova)-induced AAD models led to increased viral titre, impaired antiviral responses and increased airway hyper-responsiveness (AHR). It also resulted in exaggerated airway inflammation, more severe histopathology, increased mucus secreting cell numbers and increased IL-13. Importantly, we also showed that inhibition of IL-13 by administration of anti-IL-13 (αIL-13) monoclonal antibody during influenza infection reduced viral titre, AHR, eosinophil infiltration and MSCs, which were associated with improved antiviral IFN responses. In summary, these data highlight the important roles of PI3K and IL-13 in the increased susceptibility to influenza infection in experimental models of COPD and asthma, respectively. Such findings offer evidence for new and promising avenues for influenza disease management in these chronic lung diseases. In fact, both PI3K inhibitors and anti-IL-13 antibodies have already entered clinical trials and may be utilised as novel therapeutic approaches for influenza infections in the future.
Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Biomedical Sciences and Pharmacy.
Subjects/Keywords: influenza; asthma; COPD
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APA (6th Edition):
Warsanah, I. H. b. (2015). Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1305657
Chicago Manual of Style (16th Edition):
Warsanah, Irwan Hanish bin. “Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases.” 2015. Doctoral Dissertation, University of Newcastle. Accessed February 26, 2021.
http://hdl.handle.net/1959.13/1305657.
MLA Handbook (7th Edition):
Warsanah, Irwan Hanish bin. “Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases.” 2015. Web. 26 Feb 2021.
Vancouver:
Warsanah IHb. Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases. [Internet] [Doctoral dissertation]. University of Newcastle; 2015. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1959.13/1305657.
Council of Science Editors:
Warsanah IHb. Mechanisms of increased susceptibility to influenza infection in mouse models of chronic lung diseases. [Doctoral Dissertation]. University of Newcastle; 2015. Available from: http://hdl.handle.net/1959.13/1305657
Victoria University of Wellington
10.
Fingleton, James.
Phenotyping of obstructive airways disease.
Degree: 2013, Victoria University of Wellington
URL: http://hdl.handle.net/10063/3127
► Background Asthma and Chronic Obstructive Pulmonary Disease (COPD) are heterogeneous disorders which may be made up of different sub-types, or phenotypes, of airflow obstruction with…
(more)
▼ Background
Asthma and Chronic Obstructive Pulmonary Disease (
COPD) are heterogeneous disorders which may be made up of different sub-types, or phenotypes, of airflow obstruction with distinct clinical characteristics. To facilitate personalised treatment the different phenotypes and their response to treatment must be clearly defined and sound diagnostic rules developed.
In this thesis I explore the evidence supporting candidate phenotypes and report the results of my research, known as the New Zealand Respiratory Health Survey (NZRHS). The NZRHS was designed to determine candidate phenotypes, compare these phenotypes to those previously described, characterize their response to inhaled medication, and develop a method for allocating patients to the most appropriate phenotype.
Research Aims
-To explore clinical phenotypes of chronic airways disease by cluster analysis.
-To examine if phenotypes identified by a previous cluster analysis exist in the independent NZRHS sample.
-To compare the response to a short-acting beta-agonist inhaler between phenotype groups.
-To compare the response to a short-acting muscarinic antagonist inhaler between phenotype groups.
-To compare the response to an inhaled corticosteroid between phenotype groups.
-To generate allocation rules and determine their predictive value for the different disorders of airways disease.
Conclusions
This research has identified phenotypes of airways disease that differ significantly in their clinical and pathophysiological characteristics. Evidence is presented to support the existence of the asthma/
COPD overlap and obesity/co-morbid phenotypes and provide data of their responsiveness to inhaled corticosteroid, beta agonist and anti-muscarinic treatments, which may guide future management of patients with these phenotypes of obstructive airways disease.
Advisors/Committee Members: Beasley, Richard, Miller, John.
Subjects/Keywords: Asthma; COPD; Phenotype
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APA (6th Edition):
Fingleton, J. (2013). Phenotyping of obstructive airways disease. (Doctoral Dissertation). Victoria University of Wellington. Retrieved from http://hdl.handle.net/10063/3127
Chicago Manual of Style (16th Edition):
Fingleton, James. “Phenotyping of obstructive airways disease.” 2013. Doctoral Dissertation, Victoria University of Wellington. Accessed February 26, 2021.
http://hdl.handle.net/10063/3127.
MLA Handbook (7th Edition):
Fingleton, James. “Phenotyping of obstructive airways disease.” 2013. Web. 26 Feb 2021.
Vancouver:
Fingleton J. Phenotyping of obstructive airways disease. [Internet] [Doctoral dissertation]. Victoria University of Wellington; 2013. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10063/3127.
Council of Science Editors:
Fingleton J. Phenotyping of obstructive airways disease. [Doctoral Dissertation]. Victoria University of Wellington; 2013. Available from: http://hdl.handle.net/10063/3127
Duquesne University
11.
Srivastava, Bhavini.
Direct Incremental Costs in Chronic Obstructive Pulmonary Disease (COPD) and Asthma in United States - An Analysis of 2007 Medical Expenditure Panel Survey Data.
Degree: MS, Pharmacy Administration, 2011, Duquesne University
URL: https://dsc.duq.edu/etd/1232
► Objective: To estimate national prevalence and direct incremental expenditures in Chronic Obstructive Pulmonary Disease (COPD) and asthma using 2007 Medical Expenditure Panel Survey (MEPS) data.…
(more)
▼ Objective: To estimate national prevalence and direct incremental expenditures in Chronic Obstructive Pulmonary Disease (
COPD) and asthma using 2007 Medical Expenditure Panel Survey (MEPS) data.
Methods:
COPD and asthma were identified using ICD-9 codes and were the main independent variables. Covariates included age, gender, race, income, region, insurance and marital status. Dependent variables were total health care, office-based, outpatient, inpatient, emergency room and prescription expenditures. Descriptive statistics and regression analysis were used to fulfill the study objectives.
Results: Prevalence of
COPD and asthma was 1.3 million and 28.3 million, respectively. Total direct incremental health care expenditures per person for
COPD and asthma were 1,739.27 and 2,133.83, respectively. High cost categories among
COPD and asthma included office-based, inpatient and prescription expenditures. Age, gender, region, insurance and marital status were significant predictors for health care expenditures.
Conclusion: Results highlight socio-demographic disparities and high health care expenditures due to
COPD and asthma in the United States.
Advisors/Committee Members: Khalid M. Kamal, Jennifer Elliott, Gibbs Kanyongo.
Subjects/Keywords: Asthma; COPD; Cost
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APA (6th Edition):
Srivastava, B. (2011). Direct Incremental Costs in Chronic Obstructive Pulmonary Disease (COPD) and Asthma in United States - An Analysis of 2007 Medical Expenditure Panel Survey Data. (Masters Thesis). Duquesne University. Retrieved from https://dsc.duq.edu/etd/1232
Chicago Manual of Style (16th Edition):
Srivastava, Bhavini. “Direct Incremental Costs in Chronic Obstructive Pulmonary Disease (COPD) and Asthma in United States - An Analysis of 2007 Medical Expenditure Panel Survey Data.” 2011. Masters Thesis, Duquesne University. Accessed February 26, 2021.
https://dsc.duq.edu/etd/1232.
MLA Handbook (7th Edition):
Srivastava, Bhavini. “Direct Incremental Costs in Chronic Obstructive Pulmonary Disease (COPD) and Asthma in United States - An Analysis of 2007 Medical Expenditure Panel Survey Data.” 2011. Web. 26 Feb 2021.
Vancouver:
Srivastava B. Direct Incremental Costs in Chronic Obstructive Pulmonary Disease (COPD) and Asthma in United States - An Analysis of 2007 Medical Expenditure Panel Survey Data. [Internet] [Masters thesis]. Duquesne University; 2011. [cited 2021 Feb 26].
Available from: https://dsc.duq.edu/etd/1232.
Council of Science Editors:
Srivastava B. Direct Incremental Costs in Chronic Obstructive Pulmonary Disease (COPD) and Asthma in United States - An Analysis of 2007 Medical Expenditure Panel Survey Data. [Masters Thesis]. Duquesne University; 2011. Available from: https://dsc.duq.edu/etd/1232
University of Alberta
12.
Romaniuk Verge, Kathy.
Inhalation devices in COPD Management.
Degree: Master of Nursing, Faculty of Nursing, 2011, University of Alberta
URL: https://era.library.ualberta.ca/files/0z708x56g
► Chronic obstructive pulmonary disease (COPD) is expected to become the third most common cause of mortality in the world (GOLD Committee, 2009). COPD management continues…
(more)
▼ Chronic obstructive pulmonary disease (COPD) is
expected to become the third most common cause of mortality in the
world (GOLD Committee, 2009). COPD management continues to play a
large role in everyday medical practice and inhalation therapy will
continue to be a mainstay of COPD treatment. Very little is known
about how prescribers choose drug-delivery devices for their
clients with COPD. This study examined the current practice related
to COPD inhalation devices among physicians working in a small
rural community hospital. . Results showed that the most frequently
prescribed device for patients was a DPI in the community setting
and that nebulizers are most commonly prescribed in the emergency
department. Physicians reported various factors that they consider
when prescribing an inhalation device; ease of use for the patient,
disease severity, cost to the patient, and therapeutic response.
Physicians expressed that disease severity as the most important
factor.
Subjects/Keywords: Device; COPD; Inhalation; Prescribing
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APA (6th Edition):
Romaniuk Verge, K. (2011). Inhalation devices in COPD Management. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/0z708x56g
Chicago Manual of Style (16th Edition):
Romaniuk Verge, Kathy. “Inhalation devices in COPD Management.” 2011. Masters Thesis, University of Alberta. Accessed February 26, 2021.
https://era.library.ualberta.ca/files/0z708x56g.
MLA Handbook (7th Edition):
Romaniuk Verge, Kathy. “Inhalation devices in COPD Management.” 2011. Web. 26 Feb 2021.
Vancouver:
Romaniuk Verge K. Inhalation devices in COPD Management. [Internet] [Masters thesis]. University of Alberta; 2011. [cited 2021 Feb 26].
Available from: https://era.library.ualberta.ca/files/0z708x56g.
Council of Science Editors:
Romaniuk Verge K. Inhalation devices in COPD Management. [Masters Thesis]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/0z708x56g
Universiteit Utrecht
13.
Mulder, L.M.
Nurses’ perspectives concerning caring for and improving self-management in patients with COPD who are repeatedly admitted to a pulmonary ward.
Degree: 2012, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/252487
► Background; Chronic Obstructive Pulmonary Disease (COPD) is a public health problem. COPD can change on a daily basis, patients can have recurring exacerbations and severe…
(more)
▼ Background; Chronic Obstructive Pulmonary Disease (
COPD) is a public health problem.
COPD can change on a daily basis, patients can have recurring exacerbations and severe exacerbations results in hospital admission. By administering self-management patients can minimize the severity and/or length of the exacerbation. Unfortunately, many
COPD patients find it hard to achieve self-management. This can cause re-admission. Nurses may struggle with their feelings when patients are re-admitted. They might be less motivated to care for and guide these patients. However, little is known about the care that nurses provide and how they stay motivated to treat
COPD patients who are repeatedly admitted to a hospital. Aim and research question; Collect information about nurses’ perspectives concerning caring for and improving self-management in patients with
COPD who are repeatedly admitted to a pulmonary ward. Method; A qualitative descriptive study. Participants came from a purposeful sample of 58 nurses, working in two general hospitals, on two pulmonary wards. Semi-structured interviews were held. Thematic content analysis was used to make inferences about the perspectives. Results; Twelve nurses were interviewed. During the analysis three main themes emerged; perspectives, feelings and motivation. These main themes influence the care nurses give to and the guiding in improving self-management in patients with
COPD. Conclusion; Nurses’ care for and improving self-management in patients with
COPD is influenced by their perspectives, e.g. patients have low learning competencies, feelings, e.g. powerlessness and frustration, and their motivations. Recommendations; Barriers, like feeling frustration and not having the motivation to improve self-management, are made visible and these barriers should be taken into account when a training is developed to improve the care nurses give to patients with
COPD.
Advisors/Committee Members: Boer, F. de.
Subjects/Keywords: Nurse; Perspectives; Self-management; COPD
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APA (6th Edition):
Mulder, L. M. (2012). Nurses’ perspectives concerning caring for and improving self-management in patients with COPD who are repeatedly admitted to a pulmonary ward. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/252487
Chicago Manual of Style (16th Edition):
Mulder, L M. “Nurses’ perspectives concerning caring for and improving self-management in patients with COPD who are repeatedly admitted to a pulmonary ward.” 2012. Masters Thesis, Universiteit Utrecht. Accessed February 26, 2021.
http://dspace.library.uu.nl:8080/handle/1874/252487.
MLA Handbook (7th Edition):
Mulder, L M. “Nurses’ perspectives concerning caring for and improving self-management in patients with COPD who are repeatedly admitted to a pulmonary ward.” 2012. Web. 26 Feb 2021.
Vancouver:
Mulder LM. Nurses’ perspectives concerning caring for and improving self-management in patients with COPD who are repeatedly admitted to a pulmonary ward. [Internet] [Masters thesis]. Universiteit Utrecht; 2012. [cited 2021 Feb 26].
Available from: http://dspace.library.uu.nl:8080/handle/1874/252487.
Council of Science Editors:
Mulder LM. Nurses’ perspectives concerning caring for and improving self-management in patients with COPD who are repeatedly admitted to a pulmonary ward. [Masters Thesis]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/252487
Universiteit Utrecht
14.
Buitenhuis, S.
Onbegrip bij patiënten met astma en COPD, geassocieerd met kwaliteit van leven, zelfvertrouwen en angst voor negatieve evaluaties.
Degree: 2011, Universiteit Utrecht
URL: http://dspace.library.uu.nl:8080/handle/1874/215727
► Previous research has shown that the absence of social support and the receiving of negative social interactions are associated with lowered health related quality of…
(more)
▼ Previous research has shown that the absence of social support and the receiving of negative social interactions are associated with lowered health related quality of life. The absence of social support and the receiving of negative social interactions are similar to the experience of invalidation, which covers both discounting and lack of understanding. The goal of the present study was to examine invalidation for patients with asthma and chronic obstructive pulmonary disease (
COPD). Hypothesized was that patients with
COPD would experience more invalidation than patients with asthma. Also hypothesized was that experiencing more invalidation would be associated with lower health related quality of life. Specifically, it was hypothesized that self-esteem and fear of negative evaluation would mediate the relation between invalidation and health related quality of life. Participants were 95 patients with asthma and 159 patients with
COPD. Four questionnaires were completed by the participants to measure invalidation, health related quality of life, self-esteem and fear of negative evaluation. These questionnaires consisted respectively of the Illness Invalidation Inventory, the RAND-36 item Health Survey, the Rosenberg Self-Esteem Scale and the Fear of Negative Evaluation Scale. Results showed that patients with
COPD did not experience more invalidation than patients with asthma. The experience of invalidation was mostly related to mental health related quality of life, but only limited to physical health related quality of life. Furthermore, self-esteem and fear of negative evaluation were shown to mediate invalidation and mental health related quality of life in some situations. Future research is needed to replicate these results and should examine the possible causal role of invalidation.
Advisors/Committee Members: Kool, M..
Subjects/Keywords: Sociale Wetenschappen; Onbegrip, Astma, COPD
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APA (6th Edition):
Buitenhuis, S. (2011). Onbegrip bij patiënten met astma en COPD, geassocieerd met kwaliteit van leven, zelfvertrouwen en angst voor negatieve evaluaties. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/215727
Chicago Manual of Style (16th Edition):
Buitenhuis, S. “Onbegrip bij patiënten met astma en COPD, geassocieerd met kwaliteit van leven, zelfvertrouwen en angst voor negatieve evaluaties.” 2011. Masters Thesis, Universiteit Utrecht. Accessed February 26, 2021.
http://dspace.library.uu.nl:8080/handle/1874/215727.
MLA Handbook (7th Edition):
Buitenhuis, S. “Onbegrip bij patiënten met astma en COPD, geassocieerd met kwaliteit van leven, zelfvertrouwen en angst voor negatieve evaluaties.” 2011. Web. 26 Feb 2021.
Vancouver:
Buitenhuis S. Onbegrip bij patiënten met astma en COPD, geassocieerd met kwaliteit van leven, zelfvertrouwen en angst voor negatieve evaluaties. [Internet] [Masters thesis]. Universiteit Utrecht; 2011. [cited 2021 Feb 26].
Available from: http://dspace.library.uu.nl:8080/handle/1874/215727.
Council of Science Editors:
Buitenhuis S. Onbegrip bij patiënten met astma en COPD, geassocieerd met kwaliteit van leven, zelfvertrouwen en angst voor negatieve evaluaties. [Masters Thesis]. Universiteit Utrecht; 2011. Available from: http://dspace.library.uu.nl:8080/handle/1874/215727
McMaster University
15.
Ho, Terence.
MACROPHAGE IRON CONTENT AND EXACERBATIONS OF COPD.
Degree: MSc, 2019, McMaster University
URL: http://hdl.handle.net/11375/24600
► Background: Many COPD patients have recurrent exacerbations due to infection, but there are no valid predictors of this phenotype. Previously an observational study showed that…
(more)
▼ Background: Many COPD patients have recurrent exacerbations due to infection, but there are no valid predictors of this phenotype. Previously an observational study showed that higher iron content in sputum macrophages was associated with infectious exacerbations.
Objectives: The thesis aimed to assess the mechanisms of pulmonary macrophage iron sequestration, test the effect of macrophage iron-loading on bacterial uptake and killing, and prospectively determine if sputum hemosiderin index can predict infectious exacerbations of COPD.
Methods: Intracellular iron was measured directly and indirectly in cell-line-derived and isolated sputum macrophages after treatment with exogenous IL-6, hepcidin or heat-inactivated H.influenzae. Bacterial uptake and killing were compared in both types of macrophages, in the presence or absence of iron-loading. A prospective cohort of COPD patients had their sputum hemosiderin index measured at baseline and were monitored for 1-year for infectious exacerbations requiring admission to hospital.
Results: For pulmonary iron sequestration, IL-6 appears important, but the role of hepcidin is not clear. Iron-loading reduced the uptake of COPD-relevant organisms by almost one-third in cell-line-derived macrophage, and there was a near-significant linear relationship between sputum hemosiderin index and killing of H.influenzae (p=0.075). In terms of infective exacerbations, FEV1 had predictive utility (beta=-0.051, p=0.017) while a positive trend for sputum hemosiderin index (beta=0.035, p=0.051) suggests that this biomarker has clinical promise.
Conclusion: Through in vitro experiments and cohort data, we have established a framework suggesting that excess iron in pulmonary macrophage may contribute to recurrent bacterial airway infection in COPD. IL-6 appears to contribute to sputum macrophage iron sequestration, which subsequently may lead to immune cell dysfunction and ultimately result in an increased frequency of infective exacerbation.
Thesis
Master of Science (MSc)
COPD patients often require hospitalization due to respiratory infections (bacterial or viral) that result in worsening of their breathing. It is difficult to predict who is at high risk for this to occur, which makes it harder to prevent. Many species of bacteria depend on iron as a nutrient. We wanted to see if iron being present in certain immune cells (macrophages) in the sputum could predict these flares by: testing how iron enters these cells, seeing if bacterial growth is altered by putting iron into these cells, and following a group of COPD patients and seeing if those with higher iron in their sputum had higher risk of infectious flares. Though more testing is needed, we found that a protein often present with chronic inflammation may be associated with higher sputum macrophage iron, and that there is evidence that killing of bacteria in COPD sputum macrophages is lower with high iron, and that patients with higher sputum iron are at greater risk of having infectious flares.
Advisors/Committee Members: Nair, Parameswaran, Medical Sciences.
Subjects/Keywords: COPD; Macrophage; Iron Overload
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APA (6th Edition):
Ho, T. (2019). MACROPHAGE IRON CONTENT AND EXACERBATIONS OF COPD. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/24600
Chicago Manual of Style (16th Edition):
Ho, Terence. “MACROPHAGE IRON CONTENT AND EXACERBATIONS OF COPD.” 2019. Masters Thesis, McMaster University. Accessed February 26, 2021.
http://hdl.handle.net/11375/24600.
MLA Handbook (7th Edition):
Ho, Terence. “MACROPHAGE IRON CONTENT AND EXACERBATIONS OF COPD.” 2019. Web. 26 Feb 2021.
Vancouver:
Ho T. MACROPHAGE IRON CONTENT AND EXACERBATIONS OF COPD. [Internet] [Masters thesis]. McMaster University; 2019. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/11375/24600.
Council of Science Editors:
Ho T. MACROPHAGE IRON CONTENT AND EXACERBATIONS OF COPD. [Masters Thesis]. McMaster University; 2019. Available from: http://hdl.handle.net/11375/24600
University of Newcastle
16.
See, Hayley Victoria.
Characterising innate immune responses and the role of PD-1 in patients with COPD.
Degree: PhD, 2015, University of Newcastle
URL: http://hdl.handle.net/1959.13/1059935
► Research Doctorate - Doctor of Philosophy (PhD)
Chronic Obstructive Pulmonary Disease (COPD) affects 7.5% of Australians aged over 40 and is the fifth leading cause…
(more)
▼ Research Doctorate - Doctor of Philosophy (PhD)
Chronic Obstructive Pulmonary Disease (COPD) affects 7.5% of Australians aged over 40 and is the fifth leading cause of death in Australia. When COPD patients exacerbate, their chest symptoms and breathlessness worsen and pathogens are detected in 60% of patients. COPD patients have an increased density of antiviral CD8+ lymphocytes in the lungs. The numbers of IFN-γ-producing CD8+ lymphocytes are increased in the lungs, but there is a decrease in IFN-γ levels in the peripheral blood. IFN-γ is a key Th1 cytokine triggering upregulation of exhaustion markers, PD-1 and PD-L1. Signalling via this pathway can trigger exhaustion of T cells, leading to effector cell inhibition. We hypothesised that peripheral blood mononucleocytes (PBMCs) from COPD patients would have an altered response to common airway pathogens, and that their immune response would be reduced due to an exhausted cell phenotype. We established an in vitro model of rhinovirus-1B infection, finding the interaction of PBMCs with infected epithelium triggers HLA-DR dependent IFN-α and IFN-γ production, and that this response is impaired in PBMCs from patients with moderate to severe COPD, compared with age-matched healthy adults. Using respiratory pathogens, influenza A/H1N1, S.pneumoniae and non-typeable H.influenzae we confirmed an impaired IFN-α and IFN-γ response in COPD patients. pDCs from exacerbating COPD patients showed upregulation of PD-L1. Further to this, the proportion of effector memory CD8+ T lymphocytes (TEM) was reduced in blood from COPD patients, and this correlated with increased PD-1 expression on CD8+ T lymphocytes. Both TEM PD-1+ and increased numbers of CD8+CD44hi T lymphocytes were negatively correlated with lung function. Our findings suggest that pDCs from patients with COPD have an impaired antigen-presenting capacity and a reduced ability to secrete or elicit interferons. Worse lung function in more severe COPD patients may be driven by activation of lung CD8+ T lymphocytes and PD-1 expression, or these may simply be features of the disease process.
Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School Medicine and Public Health.
Subjects/Keywords: COPD; rhinovirus; PD-1; PBMC
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APA (6th Edition):
See, H. V. (2015). Characterising innate immune responses and the role of PD-1 in patients with COPD. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1059935
Chicago Manual of Style (16th Edition):
See, Hayley Victoria. “Characterising innate immune responses and the role of PD-1 in patients with COPD.” 2015. Doctoral Dissertation, University of Newcastle. Accessed February 26, 2021.
http://hdl.handle.net/1959.13/1059935.
MLA Handbook (7th Edition):
See, Hayley Victoria. “Characterising innate immune responses and the role of PD-1 in patients with COPD.” 2015. Web. 26 Feb 2021.
Vancouver:
See HV. Characterising innate immune responses and the role of PD-1 in patients with COPD. [Internet] [Doctoral dissertation]. University of Newcastle; 2015. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1959.13/1059935.
Council of Science Editors:
See HV. Characterising innate immune responses and the role of PD-1 in patients with COPD. [Doctoral Dissertation]. University of Newcastle; 2015. Available from: http://hdl.handle.net/1959.13/1059935
University of Newcastle
17.
Lam, Chuan En Eric.
Understanding the inflammatory mechanisms that predispose to emphysema in mouse models.
Degree: PhD, 2011, University of Newcastle
URL: http://hdl.handle.net/1959.13/928201
► Research Doctorate - Doctor of Philosophy (PhD)
Chronic obstructive pulmonary disease (COPD) is a growing global health problem, and this disorder is projected to rank…
(more)
▼ Research Doctorate - Doctor of Philosophy (PhD)
Chronic obstructive pulmonary disease (COPD) is a growing global health problem, and this disorder is projected to rank fifth by 2020 as a worldwide burden of disease (Murray and Lopez., 1996). Remarkably, little is known about the pathogenesis of COPD and current pharmacologic agents fail to halt disease progression. Emphysema is a major inflammatory disorder that falls under the clinical description of COPD. Emphysema can be induced by smoking but can also occur in non-smokers. Emerging data suggests that the loss of alveolar tissue which characterises emphysema may result from increased cell death (apoptosis) of alveolar epithelial cells mediated by the sphingolipid mediator ceramide (Petrache et al., 2005). The cause of COPD exacerbations are commonly bacterial or viral respiratory infections. Under certain conditions, immunity from infection is mediated through the initiation of apoptotic pathways by infected cells to prevent the pathogen from replicating within the host. Toll-like receptors (TLRs) recognise molecular patterns expressed by pathogens such as bacteria and viruses to initiate innate immune responses. Notably, significant amounts of the bacterial wall component lipopolysaccharide (LPS) are found in cigarette smoke. LPS is a TLR4 ligand that increases the level of the apoptotic mediator ceramide and production of proinflammatory cytokines (such as tumour necrosis factor (TNF)–α, interleukin (IL)-1β, and IL-6) implicated in the pathogenesis of emphysema. We hypothesise that chronic inhalation of LPS leads to the dysregulation of TLR4 signalling pathways that increases susceptibility to respiratory infection, and uncontrolled inflammation that promotes alveolar cell apoptosis and emphysematous-like lesions. We developed mouse models of LPS- and bacterial-induced emphysema to determine if attenuating inflammation can prevent the development of emphysema. Our results demonstrate that exposure to LPS or infection with Non-typeable Haemophilus influenzae (NTHi) (often found in patients with emphysema) can induce hallmark features of emphysema, such as alveolar enlargement (determined by mean linear intercept and percentage alveolar airspace measurements) and inflammation dominated by neutrophils and macrophages. We demonstrated that alveolar enlargement was due to the loss of alveolar parenchyma (from apoptosis), is dependent on TLR4 and myeloid differentiation factor-88 (MyD88), increased proinflammatory cytokines, chemokines, and inflammatory cells (neutrophils and macrophages) in the lung. Prophylactic administration of synthesised chemerin-derived peptide (C15) attenuated LPS- or NTHi-induced inflammation, which resulted in inhibition of the development of emphysematous-like lesions. Notably, specific depletion of alveolar macrophages protects mice from LPS- or NTHi-induced emphysema. Collectively, we demonstrate that blocking inflammation during the development of emphysema is critical for preventing or attenuating the progression of the disease.
Advisors/Committee Members: University of Newcastle. Health, Biomedical Science and Pharmacy.
Subjects/Keywords: emphysema; COPD; apoptosis; chemerin
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APA (6th Edition):
Lam, C. E. E. (2011). Understanding the inflammatory mechanisms that predispose to emphysema in mouse models. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/928201
Chicago Manual of Style (16th Edition):
Lam, Chuan En Eric. “Understanding the inflammatory mechanisms that predispose to emphysema in mouse models.” 2011. Doctoral Dissertation, University of Newcastle. Accessed February 26, 2021.
http://hdl.handle.net/1959.13/928201.
MLA Handbook (7th Edition):
Lam, Chuan En Eric. “Understanding the inflammatory mechanisms that predispose to emphysema in mouse models.” 2011. Web. 26 Feb 2021.
Vancouver:
Lam CEE. Understanding the inflammatory mechanisms that predispose to emphysema in mouse models. [Internet] [Doctoral dissertation]. University of Newcastle; 2011. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1959.13/928201.
Council of Science Editors:
Lam CEE. Understanding the inflammatory mechanisms that predispose to emphysema in mouse models. [Doctoral Dissertation]. University of Newcastle; 2011. Available from: http://hdl.handle.net/1959.13/928201
University of Tasmania
18.
Nowrin, K.
Drivers of epithelial-mesenchymal transition in chronic obstructive pulmonary disease.
Degree: 2015, University of Tasmania
URL: https://eprints.utas.edu.au/23228/1/Norwin_whole_thesis.pdf
► COPD is a chronic disease with a complex condition that involves a frequent mix of airway and lung parenchymal damage. The Global Initiative for Chronic…
(more)
▼ COPD is a chronic disease with a complex condition that involves a frequent mix of airway and lung parenchymal damage. The Global Initiative for Chronic Obstructive Lung Disease (GOLD 2014) has characterised it by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. The definition of COPD has been a bit confusing and controversial due to its difficult diagnostic procedures over the years until recently. It was stereotyped as being caused by inflammation and considered analogous to asthma (1). The current definition of COPD does not include the terms chronic bronchitis and emphysema. Chronic bronchitis is the inflammation involving cough and sputum production that is not always necessarily associated with airflow limitation. Emphysema, defined as destruction of the alveoli, a pathological feature of several structural abnormalities in COPD that can also be found in people with normal lung functions (GOLD 2014). However, it is reflected by a decline in gas-exchange rate of the alveoli of the lungs by a measurement of the O₂ (oxygen) or CO (carbon monoxide) transfer rate (diffusion capacity) and can cause worsening of airflow limitation in COPD.
Subjects/Keywords: COPD; smoking; EMT; pSmad2/3
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APA (6th Edition):
Nowrin, K. (2015). Drivers of epithelial-mesenchymal transition in chronic obstructive pulmonary disease. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/23228/1/Norwin_whole_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nowrin, K. “Drivers of epithelial-mesenchymal transition in chronic obstructive pulmonary disease.” 2015. Thesis, University of Tasmania. Accessed February 26, 2021.
https://eprints.utas.edu.au/23228/1/Norwin_whole_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nowrin, K. “Drivers of epithelial-mesenchymal transition in chronic obstructive pulmonary disease.” 2015. Web. 26 Feb 2021.
Vancouver:
Nowrin K. Drivers of epithelial-mesenchymal transition in chronic obstructive pulmonary disease. [Internet] [Thesis]. University of Tasmania; 2015. [cited 2021 Feb 26].
Available from: https://eprints.utas.edu.au/23228/1/Norwin_whole_thesis.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nowrin K. Drivers of epithelial-mesenchymal transition in chronic obstructive pulmonary disease. [Thesis]. University of Tasmania; 2015. Available from: https://eprints.utas.edu.au/23228/1/Norwin_whole_thesis.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
McMaster University
19.
Chauvin, Stephanie.
Strategies for Fall Risk Assessment and Prevention in People With COPD.
Degree: MSc, 2020, McMaster University
URL: http://hdl.handle.net/11375/25729
► Chronic obstructive pulmonary disease (COPD) is a progressive lung disease comprising of respiratory-related and systemic effects, including impairments in balance. Balance impairments are especially problematic…
(more)
▼ Chronic obstructive pulmonary disease (COPD) is a progressive lung disease comprising of respiratory-related and systemic effects, including impairments in balance. Balance impairments are especially problematic as they increase the risk of falling, potentially leading to negative outcomes such as hospitalization, disability, and death. The main objectives of this thesis were to 1. determine underlying balance impairments that distinguish between individuals with COPD with and without a history of falls and 2. explore facilitators and barriers of a home-based fall prevention program for people with COPD. The first study of this thesis was a secondary analysis of cross-sectional data that showed that the stability limits/verticality and postural responses subcomponents of the Balance Evaluation Systems Test (BESTest) distinguished between those with and without a fall history among 72 patients with moderate to severe COPD. The stability limits/verticality subcomponent also showed acceptable accuracy in identifying individuals with COPD at high risk of falls (cut-off score of 73.8%). In the second study, a qualitative analysis of interviews with 15 patients who completed a home-based fall prevention program, participants indicated that programs that are personalized and focus on providing support for older adults with COPD may help to improve adherence and reduce participants’ risk of falling. The findings from the two studies included in this thesis provide new knowledge for informing fall risk assessment and prevention for people with COPD.
Thesis
Master of Science (MSc)
Advisors/Committee Members: Beauchamp, Marla K, Rehabilitation Science.
Subjects/Keywords: COPD; Rehabilitation; Balance; Fall prevention
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APA (6th Edition):
Chauvin, S. (2020). Strategies for Fall Risk Assessment and Prevention in People With COPD. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/25729
Chicago Manual of Style (16th Edition):
Chauvin, Stephanie. “Strategies for Fall Risk Assessment and Prevention in People With COPD.” 2020. Masters Thesis, McMaster University. Accessed February 26, 2021.
http://hdl.handle.net/11375/25729.
MLA Handbook (7th Edition):
Chauvin, Stephanie. “Strategies for Fall Risk Assessment and Prevention in People With COPD.” 2020. Web. 26 Feb 2021.
Vancouver:
Chauvin S. Strategies for Fall Risk Assessment and Prevention in People With COPD. [Internet] [Masters thesis]. McMaster University; 2020. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/11375/25729.
Council of Science Editors:
Chauvin S. Strategies for Fall Risk Assessment and Prevention in People With COPD. [Masters Thesis]. McMaster University; 2020. Available from: http://hdl.handle.net/11375/25729
University of Manchester
20.
Frede, Annika.
Modulation of inflammatory responses at mucosal surfaces
by nanoparticle-based siRNA delivery.
Degree: 2016, University of Manchester
URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:301897
► In this thesis nanoparticles consisting of a calcium phosphate core encapsulated by poly(lactic-co-glycolic) acid and polyethylenimine were developed for the delivery of siRNA in vivo.…
(more)
▼ In this thesis nanoparticles consisting of a
calcium phosphate core encapsulated by poly(lactic-co-glycolic)
acid and polyethylenimine were developed for the delivery of siRNA
in vivo. The nanoparticles were efficiently endocytosed by
different cell types in vitro without exhibiting cytotoxic
characteristics. Without possessing endogenous immune response
activating properties, the nanoparticles had a highly preferable
composition for the delivery of siRNA and subsequent gene
knockdown. The delivery of siRNA with nanoparticles was tested in
two different murine disease models: DSS-induced colitis as model
for human IBD and a TH1-induced lung inflammation as model for
COPD. In IBD and
COPD chemokines and cytokines are predominant
players in the progression of the inflammatory response. The local
interference of cytokine signalling mediated by siRNA-loaded
nanoparticles might therefore be a promising new therapeutic
approach. In both murine models, the aim was to deliver siRNA
directed against inflammation related cytokines by nanoparticles
for the local treatment of mucosal inflammation.The local
administration of nanoparticles loaded with siRNA to mice suffering
from intestinal or lung inflammation led to significantly decreased
target gene expression on mRNA as well as protein level in biopsies
from the target tissues. Furthermore, reduced cytokine levels were
accompanied by diminished inflammatory pathologies and augmented
clinical signs of sickness. The results of this thesis indicate
that a specific and local modulation of inflammatory responses by
nanoparticle-based siRNA delivery is feasible and demonstrates a
major therapeutic potential.
Advisors/Committee Members: GRENCIS, RICHARD RK, Grencis, Richard, Muller, Werner.
Subjects/Keywords: siRNA delivery; nanoparticles; IBD; COPD
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APA (6th Edition):
Frede, A. (2016). Modulation of inflammatory responses at mucosal surfaces
by nanoparticle-based siRNA delivery. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:301897
Chicago Manual of Style (16th Edition):
Frede, Annika. “Modulation of inflammatory responses at mucosal surfaces
by nanoparticle-based siRNA delivery.” 2016. Doctoral Dissertation, University of Manchester. Accessed February 26, 2021.
http://www.manchester.ac.uk/escholar/uk-ac-man-scw:301897.
MLA Handbook (7th Edition):
Frede, Annika. “Modulation of inflammatory responses at mucosal surfaces
by nanoparticle-based siRNA delivery.” 2016. Web. 26 Feb 2021.
Vancouver:
Frede A. Modulation of inflammatory responses at mucosal surfaces
by nanoparticle-based siRNA delivery. [Internet] [Doctoral dissertation]. University of Manchester; 2016. [cited 2021 Feb 26].
Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:301897.
Council of Science Editors:
Frede A. Modulation of inflammatory responses at mucosal surfaces
by nanoparticle-based siRNA delivery. [Doctoral Dissertation]. University of Manchester; 2016. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:301897
University of Manitoba
21.
Alsubait, Duaa.
Effect of semaphorin 3E on airway smooth muscle cell in chronic obstructive pulmonary disease (COPD).
Degree: Immunology, 2015, University of Manitoba
URL: http://hdl.handle.net/1993/30361
► Introduction: Our objective is to investigate whether Semaphorin 3E (sema3E) regulates human airway smooth muscle cell (HASMC) proliferation in chronic obstructive pulmonary disease (COPD). Methods:…
(more)
▼ Introduction:
Our objective is to investigate whether Semaphorin 3E (sema3E) regulates human airway smooth muscle cell (HASMC) proliferation in chronic obstructive pulmonary disease (
COPD).
Methods:
HASMCs and tissues were isolated from
COPD patients. Sema3E and plexinD1 expressions were studied using Q-PCR, FACS, IHC and immunoblotting. Cell proliferation was evaluated using FACS.
Results:
HASM cells from
COPD patients express p61kDa-Sema3E isoform and plexinD1 at mRNA and protein level. Lung tissue from
COPD and healthy subjects display Sema3E immunoreactivity. Treatment with Sema3E inhibits HASM cell proliferation mediated by PDGF in healthy, but not in
COPD. HASM cells from
COPD patient display surface expression of Sema3E.
Conclusion:
The absence of effect of recombinant Sema3E in
COPD is due the constitutive expression and release of p61kDa-Sema3E isoform, which may account for airway remodeling in
COPD.
Advisors/Committee Members: Soussi Gounni, Abdelilah (Immunology) (supervisor), Uzonna, Jude (Immunology) Xie, Jiuyong (Physiology and Pathophysiology) (examiningcommittee).
Subjects/Keywords: COPD; HASMCs; Sema3E; Proliferation
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Manager
APA (6th Edition):
Alsubait, D. (2015). Effect of semaphorin 3E on airway smooth muscle cell in chronic obstructive pulmonary disease (COPD). (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/30361
Chicago Manual of Style (16th Edition):
Alsubait, Duaa. “Effect of semaphorin 3E on airway smooth muscle cell in chronic obstructive pulmonary disease (COPD).” 2015. Masters Thesis, University of Manitoba. Accessed February 26, 2021.
http://hdl.handle.net/1993/30361.
MLA Handbook (7th Edition):
Alsubait, Duaa. “Effect of semaphorin 3E on airway smooth muscle cell in chronic obstructive pulmonary disease (COPD).” 2015. Web. 26 Feb 2021.
Vancouver:
Alsubait D. Effect of semaphorin 3E on airway smooth muscle cell in chronic obstructive pulmonary disease (COPD). [Internet] [Masters thesis]. University of Manitoba; 2015. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1993/30361.
Council of Science Editors:
Alsubait D. Effect of semaphorin 3E on airway smooth muscle cell in chronic obstructive pulmonary disease (COPD). [Masters Thesis]. University of Manitoba; 2015. Available from: http://hdl.handle.net/1993/30361
University of Newcastle
22.
McDonald, Vanessa Marie.
Asthma and COPD in older people.
Degree: PhD, 2010, University of Newcastle
URL: http://hdl.handle.net/1959.13/917137
► Research Doctorate - Doctor of Philosophy (PhD)
Obstructive Airway Diseases (OAD) such as asthma and Chronic Obstructive Pulmonary Disease (COPD) are common conditions among older…
(more)
▼ Research Doctorate - Doctor of Philosophy (PhD)
Obstructive Airway Diseases (OAD) such as asthma and Chronic Obstructive Pulmonary Disease (COPD) are common conditions among older people where they are associated with a significant and increasing disease burden. The management of these conditions in older people is complex. The complexities relate to the heterogeneity that exists in asthma and COPD in the older population, the increased prevalence of co-morbidity that occurs with both advancing age and OAD, and the consequences of ageing including age related structural changes that occur in the lung. The current approach to the management of older people with asthma or COPD is to establish a diagnosis and implement disease specific clinical practice guidelines. This approach however is limited as the clinical trials that inform guidelines have largely excluded older people and those with overlap OAD or co-morbidity. A further restriction of this approach is that many of the guidelines for asthma and COPD give limited consideration to the consequences of ageing or the existence of multiple complex co-morbidities and do not necessarily address what is important to the patient. Opportunities exist to improve the management and outcomes for older people with OAD and the research undertaken in this thesis sought to do this. The research reported in this thesis aimed to improve our current understanding of Asthma, COPD and the overlap of asthma and COPD in an older population, and to develop an improved approach to the management of these patients. A mixed methods approach was used involving a cross sectional observation study, qualitative interviews and a controlled clinical trial. This research has extended our knowledge of the clinical impacts of these conditions from a biological, clinical, functional and person centred perspective and describes a management approach that significantly improves the health status of older people with OAD.
Advisors/Committee Members: University of Newcastle. Faculty of Health, School of Medicine and Public Health.
Subjects/Keywords: COPD; asthma; older people; management
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APA (6th Edition):
McDonald, V. M. (2010). Asthma and COPD in older people. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/917137
Chicago Manual of Style (16th Edition):
McDonald, Vanessa Marie. “Asthma and COPD in older people.” 2010. Doctoral Dissertation, University of Newcastle. Accessed February 26, 2021.
http://hdl.handle.net/1959.13/917137.
MLA Handbook (7th Edition):
McDonald, Vanessa Marie. “Asthma and COPD in older people.” 2010. Web. 26 Feb 2021.
Vancouver:
McDonald VM. Asthma and COPD in older people. [Internet] [Doctoral dissertation]. University of Newcastle; 2010. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1959.13/917137.
Council of Science Editors:
McDonald VM. Asthma and COPD in older people. [Doctoral Dissertation]. University of Newcastle; 2010. Available from: http://hdl.handle.net/1959.13/917137
Univerzitet u Beogradu
23.
Vujić, Tatjana V., 1964-.
Ispitivanje učestalosti i karakteristika metaboličkog
sindroma kod bolesnika sa hroničnom opstruktivnom bolešću
pluća.
Degree: Medicinski fakultet, 2018, Univerzitet u Beogradu
URL: https://fedorabg.bg.ac.rs/fedora/get/o:17384/bdef:Content/get
► medicina - interna medicina, pulmologija / Medicine - Internal medicine, Pulmonology
Hronična opstruktivna bolest pluća (HOBP) predstavlja kompleksnu i progresivnu bolest i jedan od glavnih…
(more)
▼ medicina - interna medicina, pulmologija / Medicine
- Internal medicine, Pulmonology
Hronična opstruktivna bolest pluća (HOBP)
predstavlja kompleksnu i progresivnu bolest i jedan od glavnih
uzroka morbiditeta i mortaliteta širom sveta. HOBP karakterišu
hronično ograničenje protoka vazduha u disajnim putevima i niz
patoloških promena u plućima, ali i postojanje značajnih
ekstrapulmonalnih efekata i važnih komorbiditeta koji doprinose
težini bolesti kod pojedinaca. Novija istraživanja su pokazala da
pored lokalne inflamacije na nivou pluća, u HOBP postoji i
sistemska inflamacija u čiji je nastanak verovatno uključeno više
mehanizama. Većina autora smatra da sistemska inflamacija u HOBP
nastaje “prelivanjem” inflamatornih medijatora iz pluća u sistemsku
cirkulaciju (“spill over” hipoteza), ali se navode i drugi faktori
kao duvanski dim, hipoksija, proces starenja. Intenzitet sistemske
inflamacije se povećava sa porastom težine HOBP i u toku
egzacerbacije bolesti. Pretpostavlja se da je sistemska inflamacija
osnovni patogenetski mehanizam koji povezuje HOBP i komorbiditete.
Postojanje i intenzitet sistemske inflamacije kod bolesnika sa HOBP
se mogu proceniti određivanjem nivoa inflamacijskih medijatora u
cirkulaciji: citokina, reaktanata akutne faze (C reaktivni
protein-CRP, fibrinogen i dr), kao i cirkulišućih inflamatornih
ćelija (leukociti). Metabolički sindrom (MetS) predstavlja skup
metaboličkih poremećaja (centralna gojaznost, hiperglikemija,
dislipidemija-povišeni trigliceridi i snižen HDL holesterol,
hipertenzija) koji povećavaju rizik za nastanak kardiovaskularnih
bolesti (KVB) i dijabetesa tipa 2. Prevalencija metaboličkog
sindroma kod bolesnika sa HOBP, prema različitim istraživanjima,
iznosi 21-58%. Faktori koji su povezani sa učestalom pojavom
metaboličkog sindroma kod bolesnika sa HOBP su: gojaznost, smanjena
fizička aktivnost, pušenje cigareta, primena kortikosteroida,
inflamacija, oksidativni stres, hipoksija. Kod bolesnika sa HOBP
istovremeno postojanje MetS je povezano sa češćim i dužim
egzacerbacijama i povećanim mortalitetom (MetS predisponira razvoj
kardiovaskularnih bolesti)...
Advisors/Committee Members: Nagorni Obradović, Ljudmila, 1960-.
Subjects/Keywords: COPD; metabolic syndrome; systemic
inflammation
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APA (6th Edition):
Vujić, Tatjana V., 1. (2018). Ispitivanje učestalosti i karakteristika metaboličkog
sindroma kod bolesnika sa hroničnom opstruktivnom bolešću
pluća. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:17384/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Vujić, Tatjana V., 1964-. “Ispitivanje učestalosti i karakteristika metaboličkog
sindroma kod bolesnika sa hroničnom opstruktivnom bolešću
pluća.” 2018. Thesis, Univerzitet u Beogradu. Accessed February 26, 2021.
https://fedorabg.bg.ac.rs/fedora/get/o:17384/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Vujić, Tatjana V., 1964-. “Ispitivanje učestalosti i karakteristika metaboličkog
sindroma kod bolesnika sa hroničnom opstruktivnom bolešću
pluća.” 2018. Web. 26 Feb 2021.
Vancouver:
Vujić, Tatjana V. 1. Ispitivanje učestalosti i karakteristika metaboličkog
sindroma kod bolesnika sa hroničnom opstruktivnom bolešću
pluća. [Internet] [Thesis]. Univerzitet u Beogradu; 2018. [cited 2021 Feb 26].
Available from: https://fedorabg.bg.ac.rs/fedora/get/o:17384/bdef:Content/get.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Vujić, Tatjana V. 1. Ispitivanje učestalosti i karakteristika metaboličkog
sindroma kod bolesnika sa hroničnom opstruktivnom bolešću
pluća. [Thesis]. Univerzitet u Beogradu; 2018. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:17384/bdef:Content/get
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cambridge
24.
Hoenderdos, Kim.
Modulation of neutrophil degranulation by hypoxia.
Degree: PhD, 2015, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/247459https://www.repository.cam.ac.uk/bitstream/1810/247459/3/HoenderdosPhD-final.pdf.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/247459/4/HoenderdosPhD-final.pdf.jpg
► Neutrophils are key effector cells of the innate immune system. They employ a number of powerful ‘weapons’ to eliminate pathogens, including an array of destructive…
(more)
▼ Neutrophils are key effector cells of the innate immune system. They employ a number of powerful ‘weapons’ to eliminate pathogens, including an array of destructive proteins packaged into distinctive granule subsets. In addition to their microbicidal activity, these granule proteins are capable of causing substantial tissue damage if inappropriately deployed. To mitigate against this possibility, most physiological stimuli induce minimal extracellular degranulation. Sites of inflammation and infection are usually hypoxic, and it has been shown that oxygen depletion compromises neutrophil function by impairing the generation of reactive oxygen species and hence bacterial killing.
The key finding reported in this thesis is that hypoxia substantially increases the release of all neutrophil granule subsets, as measured by the release of (active) hallmark proteins (elastase, myeloperoxidase, lactoferrin and matrix metalloproteinase-9). In consequence, supernatants from hypoxic neutrophils induced substantially more damage to lung epithelial cell layers than supernatants from neutrophils cultured under normoxic conditions; this damage was protein- and protease-dependent. This pattern of damage was seen consistently across lung adenocarcinoma-derived epithelial cells, primary immortalised lung epithelial cells, and primary human bronchial epithelial cells grown in physiological air-liquid interface culture. Surprisingly, the mechanism of hypoxia-augmented degranulation was found to be independent of protein synthesis and specifically, of the transcription factor HIF-1α (the ‘master-regulator’ of hypoxic responses); thus, hypoxia did not affect mRNA transcript or protein abundance of the major granule components, and hypoxia mimetics failed to recapitulate the phenotype. Inhibition of the key pathways known to be involved in neutrophil degranulation, including, phosphatidylinositol 3-kinase and phospholipase C, but not calcium flux prevented augmented granule release under hypoxia
In conclusion, hypoxia induces a destructive neutrophil phenotype, with increased release of multiple histotoxic proteases. This may contribute to tissue injury and disease pathogenesis in a range of clinically important conditions.
Subjects/Keywords: Neutrophil; Degranulation; Hypoxia; COPD; Immunology
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Manager
APA (6th Edition):
Hoenderdos, K. (2015). Modulation of neutrophil degranulation by hypoxia. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/247459https://www.repository.cam.ac.uk/bitstream/1810/247459/3/HoenderdosPhD-final.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/247459/4/HoenderdosPhD-final.pdf.jpg
Chicago Manual of Style (16th Edition):
Hoenderdos, Kim. “Modulation of neutrophil degranulation by hypoxia.” 2015. Doctoral Dissertation, University of Cambridge. Accessed February 26, 2021.
https://www.repository.cam.ac.uk/handle/1810/247459https://www.repository.cam.ac.uk/bitstream/1810/247459/3/HoenderdosPhD-final.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/247459/4/HoenderdosPhD-final.pdf.jpg.
MLA Handbook (7th Edition):
Hoenderdos, Kim. “Modulation of neutrophil degranulation by hypoxia.” 2015. Web. 26 Feb 2021.
Vancouver:
Hoenderdos K. Modulation of neutrophil degranulation by hypoxia. [Internet] [Doctoral dissertation]. University of Cambridge; 2015. [cited 2021 Feb 26].
Available from: https://www.repository.cam.ac.uk/handle/1810/247459https://www.repository.cam.ac.uk/bitstream/1810/247459/3/HoenderdosPhD-final.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/247459/4/HoenderdosPhD-final.pdf.jpg.
Council of Science Editors:
Hoenderdos K. Modulation of neutrophil degranulation by hypoxia. [Doctoral Dissertation]. University of Cambridge; 2015. Available from: https://www.repository.cam.ac.uk/handle/1810/247459https://www.repository.cam.ac.uk/bitstream/1810/247459/3/HoenderdosPhD-final.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/247459/4/HoenderdosPhD-final.pdf.jpg
University of California – San Francisco
25.
Chyall, Lawrence Henry.
Patterns of Fatigue in Chronic Obstructive Pulmonary Disease.
Degree: Nursing, 2011, University of California – San Francisco
URL: http://www.escholarship.org/uc/item/3rt4r3w5
► Purpose:To describe the patterns of fatigue and the symptom/well being and physical/physiological correlates of fatigue over one year in patients with COPD.Patients and Methods:Secondary analysis…
(more)
▼ Purpose:To describe the patterns of fatigue and the symptom/well being and physical/physiological correlates of fatigue over one year in patients with COPD.Patients and Methods:Secondary analysis of data from a prospective, randomized, single-blind study to evaluate the effect of three different doses of supervised exercise in a dyspnea self -management program in patients with stable chronic obstructive pulmonary disease (N = 103; age 66 ± 8, females 57; FEV1 44.8% ± 14% predicted). Results:Mean fatigue was stable at the measurement times during the course of the study. Four patterns of fatigue were identified "stable" (n=29), "improving/stable" (n=28), "worsening/stable" (n=18) and "labile" (n=4). Fatigue was moderately correlated with dyspnea, depressive and anxious symptoms, and reduced quality of life. Fatigue was mildly correlated with reduced exercise performance. Conclusions:Mean fatigue is not a sufficient measure of fatigue over time in patients with chronic obstructive pulmonary disease. Subgroup analysis may be necessary to understand fatigue in this population.
Subjects/Keywords: Nursing; COPD; dyspnea; fatigue
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APA (6th Edition):
Chyall, L. H. (2011). Patterns of Fatigue in Chronic Obstructive Pulmonary Disease. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/3rt4r3w5
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Chyall, Lawrence Henry. “Patterns of Fatigue in Chronic Obstructive Pulmonary Disease.” 2011. Thesis, University of California – San Francisco. Accessed February 26, 2021.
http://www.escholarship.org/uc/item/3rt4r3w5.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Chyall, Lawrence Henry. “Patterns of Fatigue in Chronic Obstructive Pulmonary Disease.” 2011. Web. 26 Feb 2021.
Vancouver:
Chyall LH. Patterns of Fatigue in Chronic Obstructive Pulmonary Disease. [Internet] [Thesis]. University of California – San Francisco; 2011. [cited 2021 Feb 26].
Available from: http://www.escholarship.org/uc/item/3rt4r3w5.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Chyall LH. Patterns of Fatigue in Chronic Obstructive Pulmonary Disease. [Thesis]. University of California – San Francisco; 2011. Available from: http://www.escholarship.org/uc/item/3rt4r3w5
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manitoba
26.
Polak Scowcroft, Caroline Elizabeth.
Life's changing landscape - exploring the experiences of people with COPD: an analysis of public narratives.
Degree: Disability Studies, 2014, University of Manitoba
URL: http://hdl.handle.net/1993/23135
► In this study, data and information publicly available on the Internet were analysed to examine the self-reported experiences of people with COPD. Chronic Obstructive Pulmonary…
(more)
▼ In this study, data and information publicly available on the Internet were analysed to examine the self-reported experiences of people with
COPD. Chronic Obstructive Pulmonary Disease (
COPD) is a chronic progressive disease that may exist with and worsen many other conditions of ageing. The theoretical basis for analysis draws on the social model of disability that stresses the disabling aspects of the environment, as opposed to the individual’s medical condition. This allows the voices and stories of people living life with
COPD to be the focus of this research. In this study, I found that people with
COPD who post their stories to the Internet display a wide range of emotions and experiences of living with
COPD. The people with
COPD discuss, amongst other things, how
COPD has affected their home life and activities of daily living, their work and finances, their spouse or carer, and especially appreciate the friendships and support found at pulmonary rehabilitation and through belonging to a support group. These people appear to be very open and authentic in their writings, wishing to reach out to others with the condition to offer hope, support and advice, in adapting to changing circumstances as the condition progresses. People expressed gratitude at being part of a community of fellow people with
COPD. This collection of stories shows that, despite having a disabling condition, people with
COPD can demonstrate resilience and resourcefulness to successfully adjust the landscape of their lives, and the realities of living with a disability, to maintain a good quality of life for as long as possible.
Advisors/Committee Members: Hansen, Nancy (Disability Studies) (supervisor), Kaufert, Joe (Community Health Sciences) Lutfiyya, Zana (Education) (examiningcommittee).
Subjects/Keywords: Disability; COPD; Geography; Netnography
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APA (6th Edition):
Polak Scowcroft, C. E. (2014). Life's changing landscape - exploring the experiences of people with COPD: an analysis of public narratives. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/23135
Chicago Manual of Style (16th Edition):
Polak Scowcroft, Caroline Elizabeth. “Life's changing landscape - exploring the experiences of people with COPD: an analysis of public narratives.” 2014. Masters Thesis, University of Manitoba. Accessed February 26, 2021.
http://hdl.handle.net/1993/23135.
MLA Handbook (7th Edition):
Polak Scowcroft, Caroline Elizabeth. “Life's changing landscape - exploring the experiences of people with COPD: an analysis of public narratives.” 2014. Web. 26 Feb 2021.
Vancouver:
Polak Scowcroft CE. Life's changing landscape - exploring the experiences of people with COPD: an analysis of public narratives. [Internet] [Masters thesis]. University of Manitoba; 2014. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/1993/23135.
Council of Science Editors:
Polak Scowcroft CE. Life's changing landscape - exploring the experiences of people with COPD: an analysis of public narratives. [Masters Thesis]. University of Manitoba; 2014. Available from: http://hdl.handle.net/1993/23135
University of Illinois – Chicago
27.
Kim, Inah.
Sleep Disturbance and Physical Activity in Chronic Obstructive Pulmonary Disease.
Degree: 2018, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/22672
► Background: Chronic obstructive pulmonary disease (COPD) is a highly prevalent chronic respiratory disease and the third-leading cause of death in the U.S. Physical inactivity and…
(more)
▼ Background: Chronic obstructive pulmonary disease (
COPD) is a highly prevalent chronic respiratory disease and the third-leading cause of death in the U.S. Physical inactivity and sleep disturbance are much more problematic in this population than in healthy individuals; the related negative health outcomes include
COPD exacerbation, hospitalization, and increased mortality. Research examining the association between sleep and physical activity (PA) in this population is limited. The purpose of this study was to identify the impact of night-time sleep on next-day PA in people with co-existing
COPD and disturbed sleep using both subjectively and objectively measured sleep variables.
Method: In this secondary analysis with a repeated-measure, quantitative design, 56 mild-to-severe
COPD patients who reported disturbed sleep were drawn from the baseline dataset of an ongoing randomized control trial examining efficacy and mechanisms of components of insomnia therapy on insomnia and fatigue in
COPD patients. Sleep and PA were measured using the accelerometer (Actiwatch-2, Philips Respironics, Murrysville, PA) over 5 days. Night-time sleep variables included sleep onset latency (SL), sleep efficiency (SE), wake after sleep onset (WASO), total sleep time (TST), and number of awakenings (NA); PA variables included averaged daily (from awakening to bedtime) and hourly activity counts per minute. Spearman correlations and mixed-effect modeling were performed using the SPSS 24.0 program (SPSS Inc., Chicago, IL).
Results: The mean age of the participants was 65.1 years; and 53.6% were male. The mean predicted FEV1% was 69.5; and 60.7% of participants had moderate pulmonary function based on the GOLD standard. Greater mean daily PA negatively associated with SL (r=-0.48, p <.001), NA (r=-0.38, p <.01), TST (r=-0.50, p<.001), and age (r=-0.32, p<.05). Increased SL was associated with less next-day PA during afternoon and evening (4-6 p.m.). Greater WASO and NA were associated with less next-morning PA (5-8 a.m.). Greater TST was associated with less next-morning PA (12 a.m.-12 p.m.), and greater SE was associated with less next-morning (1-4 a.m.) and more evening PA (5-7 p.m.).
Conclusion: This study identified a significant influence of night-time sleep on next-day PA in people with co-existing
COPD and sleep disturbance. These results provide evidence supporting the potential value of effective sleep management to promote physical activity in people with
COPD. Further research is needed to identify mechanisms underlying the sleep-PA relationship.
Advisors/Committee Members: Kapella, Mary C. (advisor), Collins, Eileen G. (committee member), Quinn, Laurie (committee member), Bronas, Ulf (committee member), Park, Chang G. (committee member), Horswill, Craig (committee member), Kapella, Mary C. (chair).
Subjects/Keywords: Physical activity
Sleep disturbance
COPD
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Manager
APA (6th Edition):
Kim, I. (2018). Sleep Disturbance and Physical Activity in Chronic Obstructive Pulmonary Disease. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22672
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kim, Inah. “Sleep Disturbance and Physical Activity in Chronic Obstructive Pulmonary Disease.” 2018. Thesis, University of Illinois – Chicago. Accessed February 26, 2021.
http://hdl.handle.net/10027/22672.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kim, Inah. “Sleep Disturbance and Physical Activity in Chronic Obstructive Pulmonary Disease.” 2018. Web. 26 Feb 2021.
Vancouver:
Kim I. Sleep Disturbance and Physical Activity in Chronic Obstructive Pulmonary Disease. [Internet] [Thesis]. University of Illinois – Chicago; 2018. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/10027/22672.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kim I. Sleep Disturbance and Physical Activity in Chronic Obstructive Pulmonary Disease. [Thesis]. University of Illinois – Chicago; 2018. Available from: http://hdl.handle.net/10027/22672
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Manchester
28.
Aul, Raminder Singh.
Bronchial challenges in airways disease.
Degree: Thesis (M.D.), 2013, University of Manchester
URL: https://www.research.manchester.ac.uk/portal/en/theses/bronchial-challenges-in-airways-disease(427734bd-d3e2-48be-b6bb-b760da1b333d).html
;
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568634
► Background: Airways diseases comprise mainly of COPD and asthma. There is a need to develop both new models and improve methodologies of existing models these…
(more)
▼ Background: Airways diseases comprise mainly of COPD and asthma. There is a need to develop both new models and improve methodologies of existing models these diseases. LPS challenges in smokers would be an excellent model to study the drugs directed against TLR4 mediated inflammation in COPD. In asthma allergen challenges are established models of disease and extensively used in clinical trials. Back to back reproducibility of two bolus dose allergen challenges has not been studied; this would provide intra subject standard deviations which are useful for accurate power calculations for bolus allergen challenge studies. Aims: 1. To investigate Inhaled LPS Challenges in healthy smokers as a model of inflammation in COPD; study systemic and sputum biomarkers for use in such studies and use LPS challenge as a model to study corticosteroid insensitivity 2. Investigate LPS Challenges in HNS as a model to study neutrophil chemotaxis mechanisms 3. Study Reproducibility of bolus dose allergen challengeMethods 1. HNS and HS were recruited and underwent inhaled LPS challenges. Safety, airway and systemic inflammation was studied. 2. Mild atopic asthmatics underwent two bolus allergen challenges, reproducibility of EAR and LAR was studied and intrasubject SD was used for power calculationsResult LPS Challenges were safe in both HNS and HS and led to increase in sputum neutrophil% in both these populations with maximum effect at 6hours post 30µg LPS inhalation. The resulting airway neutrophilic inflammation was reproducible in HS. LPS challenge in HS also leads to increase in systemic biomarkers and upregulation of NFĸB pathways in induced sputum. There was moderate corticosteroid insensitivity in airway inflammation in HS which didnot increase post LPS challenge. In HNS sputum supernatants post LPS challenge increase chemotaxis of blood neutrophils which is related to CXCL8 levels and mediated by both CXCR1 and 2 receptors. Bolus allergen challenges in mild asthmatics show good reproducibility for both EAR and LAR; I have also presented intrasubject SD which maybe used for accurate power calculations for future studies.Conclusions LPS Challenges lead to neutrophilic airway inflammation in HS which is reproducible and mediated by upregulation of TLR4 signalling making this a good model to study anti-inflammatory drugs for COPD in clinical trials. Additionally, LPS challenges in HNS provide a model to study neutrophil chemotaxis mechanisms. Bolus allergen challenges show good reproducibility and accurate power calculations are presented in this thesis.
Subjects/Keywords: 616.2; LPS Challenge; COPD
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APA (6th Edition):
Aul, R. S. (2013). Bronchial challenges in airways disease. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/bronchial-challenges-in-airways-disease(427734bd-d3e2-48be-b6bb-b760da1b333d).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568634
Chicago Manual of Style (16th Edition):
Aul, Raminder Singh. “Bronchial challenges in airways disease.” 2013. Doctoral Dissertation, University of Manchester. Accessed February 26, 2021.
https://www.research.manchester.ac.uk/portal/en/theses/bronchial-challenges-in-airways-disease(427734bd-d3e2-48be-b6bb-b760da1b333d).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568634.
MLA Handbook (7th Edition):
Aul, Raminder Singh. “Bronchial challenges in airways disease.” 2013. Web. 26 Feb 2021.
Vancouver:
Aul RS. Bronchial challenges in airways disease. [Internet] [Doctoral dissertation]. University of Manchester; 2013. [cited 2021 Feb 26].
Available from: https://www.research.manchester.ac.uk/portal/en/theses/bronchial-challenges-in-airways-disease(427734bd-d3e2-48be-b6bb-b760da1b333d).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568634.
Council of Science Editors:
Aul RS. Bronchial challenges in airways disease. [Doctoral Dissertation]. University of Manchester; 2013. Available from: https://www.research.manchester.ac.uk/portal/en/theses/bronchial-challenges-in-airways-disease(427734bd-d3e2-48be-b6bb-b760da1b333d).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568634
University of Gothenburg / Göteborgs Universitet
29.
McCrae, Christopher.
Host-Virus Interactions in Asthma and COPD.
Degree: 2018, University of Gothenburg / Göteborgs Universitet
URL: http://hdl.handle.net/2077/56929
► Asthma and chronic obstructive pulmonary disease (COPD) are associated with periods of worsened symptoms, known as exacerbations. Severe exac-erbations can result in hospitalisation, irreversible decline…
(more)
▼ Asthma and chronic obstructive pulmonary disease (COPD) are associated with periods of worsened symptoms, known as exacerbations. Severe exac-erbations can result in hospitalisation, irreversible decline of the disease and sometimes death. Thus, exacerbations are a major cause of morbidity, mortality and healthcare cost. Treatment or prevention of exacerbations is an area of unmet medical need as the current standard of care has insuffi-cient impact on exacerbation frequency and severity.
Respiratory viral infections are hypothesized to be important triggers of exacerbations. It has been shown that 41-95% of asthma exacerbations and 22-57% of COPD exacerbations are associated with a respiratory virus in-fection, the most common agent being human rhinovirus (RV). Other vi-ruses frequently associated with exacerbations include respiratory syncytial virus and influenza. Prevention or attenuation of respiratory virus infec-tions could therefore have significant impact on exacerbation frequency and severity.
The mechanisms by which viruses trigger exacerbations are poorly un-derstood, although there is evidence for defective anti-viral interferon (IFN) responses in cells from patients with asthma and COPD. Further investiga-tion of host-virus interactions and their impact on underlying airway dis-ease, may lead to novel therapeutic targets for the prevention of exacerba-tions.
We investigated host-virus interactions in asthma and COPD through a multi-faceted approach. First, we performed an in vitro functional ge-nomics screen using RNA interference (RNAi), to identify targets that are essential for RV replication in primary normal human bronchial epithelial cells. Second, we evaluated the efficacy of inhaled IFNβ-1a for the preven-tion of severe asthma exacerbations in a Phase 2 trial. Finally, we per-formed an observational, longitudinal study in COPD patients to investi-gate the relationship between exacerbations, viral and bacterial infections, air pollution and anti-microbial peptides (AMPs).
In the first study, we identified lanosterol synthase (LSS) as a potential therapeutic target which, when inhibited, blocks RV replication and en-hances the RV-induced IFNβ response. We discovered that the mechanism of this effect was related to the induction of a regulatory sterol, 24(S),25 epoxycholesterol.
In our phase 2 trial (INEXAS), we found that inhaled IFNβ-1a did not prevent the occurrence of severe asthma exacerbations, but improved peak expiratory flow (PEF). In an exploratory analysis, we also identified poten-tial responder subgroups, based on blood eosinophil counts or serum inter-leukin (IL)-18 levels.
In our COPD cohort, we found that both viral infections and increases in ambient air pollution were associated with exacerbations. Viral exacerba-tions were strongly associated with upregulation of the IFN response bi-omarkers, CXCL10, CXCL11 and IFNγ. We went on to discover that the levels of beta-defensin 2 (hBD-2), an AMP expressed by the lung epitheli-um, is reduced in the sputum of patients who experienced…
Subjects/Keywords: Asthma; COPD; Exacerbation; Virus; Interferon
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APA (6th Edition):
McCrae, C. (2018). Host-Virus Interactions in Asthma and COPD. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/56929
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
McCrae, Christopher. “Host-Virus Interactions in Asthma and COPD.” 2018. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 26, 2021.
http://hdl.handle.net/2077/56929.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
McCrae, Christopher. “Host-Virus Interactions in Asthma and COPD.” 2018. Web. 26 Feb 2021.
Vancouver:
McCrae C. Host-Virus Interactions in Asthma and COPD. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2018. [cited 2021 Feb 26].
Available from: http://hdl.handle.net/2077/56929.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
McCrae C. Host-Virus Interactions in Asthma and COPD. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2018. Available from: http://hdl.handle.net/2077/56929
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Kristianstad University
30.
Axelsson, Linn.
Sambandet mellan parodontit och KOL.
Degree: Health and Society, 2014, Kristianstad University
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-12127
► Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. The disease is the fourth leading cause of death and more than 5 percent…
(more)
▼ Chronic obstructive pulmonary disease (COPD) is a chronic lung disease. The disease is the fourth leading cause of death and more than 5 percent of the adult population worldwide is affected. The aim of this study was to investigate the association between periodontitis and COPD. Search for material for the literature review was done in the medical database PubMed where the keywords were: "Chronic obstructive pulmonary disease" and "Periodontal health or periodontal disease". The result is based on twelve studies that were extracted and analyzed. The studies have investigated pocket depth, attachment loss, plaque index, bleeding on probing and bone loss. Ten studies compared a COPD group with a healthy control group, one study compared two COPD groups and one study examined a COPD group and a group with other lung diseases. Most studies found that people with COPD had a higher incidence of pocket depth, attachment loss, plaque index, bleeding on probing and bone loss. The conclusion of the literature review is that there is an association between periodontitis and COPD and that smoking is a link between the two diseases.
Kronisk obstruktiv lungsjukdom (KOL) är en kronisk lungsjukdom. Sjukdomen är den fjärde vanligaste dödsorsaken och mer än 5 procent av den vuxna befolkningen i världen är drabbade. Syftet med litteraturstudien var att undersöka sambandet mellan parodontit och KOL. Sökning efter material till litteraturstudien gjordes i den medicinska databasen PubMed där sökorden var: ”Chronic obstructive pulmonary disease” och ”Periodontal health or periodontal disease”. Resultatet är baserat på tolv vetenskapliga studier som har analyserats och granskats. Studierna har undersökt fickdjup, fästeförlust, plackindex, blödning vid sondering och benförlust. Tio studier jämförde en KOL-grupp med en frisk kontrollgrupp, en studie jämförde två KOL-grupper och en studie undersökte en KOL-grupp och en grupp med andra lungsjukdomar. Flertalet studier kom fram till att personer med KOL hade högre förekomst av fickdjup, fästeförlust, plackindex, blödning vid sondering och benförlust. Slutsatsen är att det fanns ett samband mellan parodontit och KOL och att rökning har en koppling mellan sjukdomarna.
Subjects/Keywords: COPD; periodontitis; KOL; parodontit
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Manager
APA (6th Edition):
Axelsson, L. (2014). Sambandet mellan parodontit och KOL. (Thesis). Kristianstad University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-12127
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Axelsson, Linn. “Sambandet mellan parodontit och KOL.” 2014. Thesis, Kristianstad University. Accessed February 26, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-12127.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Axelsson, Linn. “Sambandet mellan parodontit och KOL.” 2014. Web. 26 Feb 2021.
Vancouver:
Axelsson L. Sambandet mellan parodontit och KOL. [Internet] [Thesis]. Kristianstad University; 2014. [cited 2021 Feb 26].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-12127.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Axelsson L. Sambandet mellan parodontit och KOL. [Thesis]. Kristianstad University; 2014. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-12127
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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Open Access Theses and Dissertations
