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1. ROCHA JÚNIOR, Laurindo Ferreira da. Determinação de citocinas da via TH17 e da atividade imunomoduladora do novo derivado Tiazolidínico LPSF/TM17, agonista do PPARy, em células do sangue periférico de pacientes portadores de artrite reumatoide .

Degree: 2013, Universidade Federal de Pernambuco

A artrite reumatoide (AR) é uma doença autoimune inflamatória sistêmica que tem como característica principal o acometimento articular. As citocinas estão diretamente implicadas na patogênese da AR. Este trabalho objetivou determinar os níveis de citocinas da via Th17, particularmente IL-17A e IL-22 e correlacionar seus níveis séricos com dados clínicos, demográficos, radiológicos e laboratoriais de pacientes com AR, bem como avaliar a atividade imunomoduladora do novo derivado tiazolidínico LPSF/TM17. Os pacientes foram provenientes do Hospital das Clínicas da Universidade Federal de Pernambuco (UFPE). A coleta de dados clínico-demográficos foi realizada por questionário específico e os pacientes que preencheram os critérios de inclusão realizaram coleta do sangue periférico. A quantificação de citocinas foi realizada em 83 pacientes e 30 controles saudáveis por ELISA. Os níveis de IL-22 mostraram-se aumentados nos pacientes (média 432,37 pg/ml) quando comparados aos controles (67,45 pg/ml), p<0,001. Houve correlação da IL-22 com os índices clínicos de atividade de doença DAS28 (p = 0.037) e CDAI (p = 0.013). Houve correlação dos níveis desta citocina com a presença de erosões radiográficas (p = 0.0001) e com a presença do autoanticorpo fator reumatoide (p = 0.001). Visando avaliar o efeito imunomodulador do LPSF/TM17, foram dosadas citocinas em sobrenadantes de culturas de células mononucleares periféricas após estimulação com PMA e Ionomicina de parte destes pacientes com AR (IFNγ, IL-17A, IL-6 e IL-22). O LPSF/TM17 inibiu significativamente a produção de IFNγ na concentração de 100μM e de IL-17A e IL-22 nas concentrações de 1, 10 e 100 μM (p<0,05). Este estudo foi pioneiro em associar os níveis de IL-22 com a gravidade da doença implicando importante papel desta citocina na patogênese da AR. O presente estudo mostrou a associação da IL-22 na patogênese da AR e que, nessa doença, o LPSF/TM17 pode ser importante na abordagem terapêutica, uma vez que inibiu citocinas envolvidas na doença (IFNγ, IL-17ª e IL-22). Advisors/Committee Members: Pitta, Maira Galdino da Rocha (advisor), DUARTE, Ângela Luzia Branco Pinto (advisor), http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4705790A6 (advisor).

Subjects/Keywords: Artrite reumatoide; derivado tiazolidínico; CDAI; DAS28; interleucina-22; interleucina-17A

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

ROCHA JÚNIOR, L. F. d. (2013). Determinação de citocinas da via TH17 e da atividade imunomoduladora do novo derivado Tiazolidínico LPSF/TM17, agonista do PPARy, em células do sangue periférico de pacientes portadores de artrite reumatoide . (Thesis). Universidade Federal de Pernambuco. Retrieved from http://repositorio.ufpe.br/handle/123456789/14905

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

ROCHA JÚNIOR, Laurindo Ferreira da. “Determinação de citocinas da via TH17 e da atividade imunomoduladora do novo derivado Tiazolidínico LPSF/TM17, agonista do PPARy, em células do sangue periférico de pacientes portadores de artrite reumatoide .” 2013. Thesis, Universidade Federal de Pernambuco. Accessed September 22, 2019. http://repositorio.ufpe.br/handle/123456789/14905.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

ROCHA JÚNIOR, Laurindo Ferreira da. “Determinação de citocinas da via TH17 e da atividade imunomoduladora do novo derivado Tiazolidínico LPSF/TM17, agonista do PPARy, em células do sangue periférico de pacientes portadores de artrite reumatoide .” 2013. Web. 22 Sep 2019.

Vancouver:

ROCHA JÚNIOR LFd. Determinação de citocinas da via TH17 e da atividade imunomoduladora do novo derivado Tiazolidínico LPSF/TM17, agonista do PPARy, em células do sangue periférico de pacientes portadores de artrite reumatoide . [Internet] [Thesis]. Universidade Federal de Pernambuco; 2013. [cited 2019 Sep 22]. Available from: http://repositorio.ufpe.br/handle/123456789/14905.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ROCHA JÚNIOR LFd. Determinação de citocinas da via TH17 e da atividade imunomoduladora do novo derivado Tiazolidínico LPSF/TM17, agonista do PPARy, em células do sangue periférico de pacientes portadores de artrite reumatoide . [Thesis]. Universidade Federal de Pernambuco; 2013. Available from: http://repositorio.ufpe.br/handle/123456789/14905

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


Boston University

2. Kreps, David Joseph. Obesity, weight change and disease activity measures in patients with rheumatoid arthritis.

Degree: MS, Medical Sciences, 2016, Boston University

BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammatory polyarthritis, typically of the small joints. Obesity, a serious global epidemic, has been shown to increase systemic inflammatory biomarkers, several of which are related to RA pathophysiology. Associations have been observed between obesity and worsened RA disease activity outcomes in crosssectional studies. Limited longitudinal studies investigated the effects of weight change on RA disease activity measures. Surgical interventions for weight loss in RA patients showed marked improvement in RA disease activity measures and outcomes but typical weight change in a clinical setting has not been investigated. OBJECTIVE: To investigate the impact of typical weight change on RA disease activity measures. METHODS: We conducted a retrospective cohort study on 178 RA patients seen in typical clinical practice that met the inclusion criteria for the study, which included patients with a minimum of two clinical disease activity assessments (CDAI) with corresponding body mass index (BMI) measures. Medical record review was conducted for each clinic visit where CDAI and BMI were measured, and at each of these visits, sociodemographic, lifestyle, medication usage, questionnaire data, RA characteristics, laboratory values, and comorbidities were collected. Linear regression was used to analyze the association between ΔBMI and ΔCDAI, defined at the dates of minimum and maximum BMI for each subject, adjusting for confounders including sex, age, disease duration, smoking status, serologic status, and steroid usage. Logistic regression was performed to evaluate whether ΔBMI was associated with low/remission RA disease activity according to accepted CDAI cutoffs. RESULTS: Unadjusted linear regression was performed on all 178 subjects to analyze the overall trend within the sample population. For every 1 kg/m2 increase in BMI, CDAI increased by 0.49 points, but these results were not statistically significant (p=0.155, 95%CI -0.176, 1.097). Subjects were stratified into BMI gain, stable, and loss groups. Within the BMI loss group (defined as those whose BMI decreased by more than 1 kg/m2), a significant association was found with ΔCDAI (β= -2.61 [p=0.028, 95%CI -4.91, -0.298]). Unadjusted linear regression on the BMI gain and stable groups was found to be not statistically significant. This association remained significant after adjusting for sex, age, disease duration, smoking status, serologic status, and steroid usage (β=-2.499 [p=0.044, 95%CI -4.94, -0.061]). There was no association between ΔBMI and low/remission RA disease activity (OR 0.990, (95%CI 0.855, 1.146). When stratified by BMI gain, stable, and loss groups there was no significant association with low/remission RA disease activity. CONCLUSION: These results suggest that weight loss may be associated with improved disease activity among patients with RA seen in a typical clinical setting. Weight loss has the potential to be a non-pharmacologic…

Subjects/Keywords: Medicine; BMI; CDAI; RA; Obesity; Rheumatoid arthritis; Weight change

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kreps, D. J. (2016). Obesity, weight change and disease activity measures in patients with rheumatoid arthritis. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/16819

Chicago Manual of Style (16th Edition):

Kreps, David Joseph. “Obesity, weight change and disease activity measures in patients with rheumatoid arthritis.” 2016. Masters Thesis, Boston University. Accessed September 22, 2019. http://hdl.handle.net/2144/16819.

MLA Handbook (7th Edition):

Kreps, David Joseph. “Obesity, weight change and disease activity measures in patients with rheumatoid arthritis.” 2016. Web. 22 Sep 2019.

Vancouver:

Kreps DJ. Obesity, weight change and disease activity measures in patients with rheumatoid arthritis. [Internet] [Masters thesis]. Boston University; 2016. [cited 2019 Sep 22]. Available from: http://hdl.handle.net/2144/16819.

Council of Science Editors:

Kreps DJ. Obesity, weight change and disease activity measures in patients with rheumatoid arthritis. [Masters Thesis]. Boston University; 2016. Available from: http://hdl.handle.net/2144/16819

.