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You searched for subject:(CD1d NKT lymphocytes). One record found.

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1. Anastasiadis, Athanasios. Μελέτη του ανοσορρυθμιστικού άξονα ΝΚΤ λεμφοκυττάρων - CD1d στα λεμφοϋπερπλαστικά σύνδρομα.

Degree: 2013, Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ)

CD1d is an antigen-presenting molecule expressed on the surface of many cells of the immune system, mainly immature and mature B lymphocytes (except those in the germinal center), and monocytes and macrophages. CD1d presents lipid antigens to a specific subcategory of T lymphocytes, NKT lymphocytes. The latter, when activated, secrete a wide variety of cytokines, mobilizing in turn all the cells of the immune system.B-Cell Lymphproliferative Disorders (B-LPD’s) are a diverse group of neoplasms of the lymphatic system, derived from malignant transformation of either developing or mature B-lymphocytes. They differ among themselves in their clinical and laboratory features and, more importantly, in their prognosis. Charting of the surface of malignant cells of B-LPD’s by methods of flow cytometry and discovering genetic disorders using molecular techniques has led to the determination of useful prognostic markers for these disorders. These markers are particularly important in the case of low grade B-LPD’s, which run an indolent course and for which immediate or intensive treatment is not always necessary.In the present study we determined CD1d expression on the surface of malignant cells of patients with 5 different low grade B-LPD’s [120 with chronic lymphocytic leukemia (CLL), of who 96 were treatment-naïve, 17 with mantle cell lymphoma (MCL), 10 with splenic marginal zone lymphoma (SMZL), 17 with lymphoplasmacytic lymphoma (LPL) and 14 with hairy cell leukemia (HCL)]. CD1d expression was determined as mean fluorescence intensity (CD1d MFI) of lymphoma cells to that of normal T cells, which are CD1d negative. We also compared CD1d expression among certain pairs of the aforementioned low grade B-LPD’s. Finally, we correlated CD1d expression with demographics and clinical characteristics of CLL patients, as well as with their survival data.CD1d expression of neoplastic cells of CLL patients was particularly low. CD1d expression in the rest B-LPD’s was high, peaking in HCL. There was a statistically significant difference in CD1d expression among CLL and MCL, as well as among SMZL and LPL. These neoplasms were studied in pairs because problems in their differential diagnosis occur frequently.In CLL we determined a positive correlation between the expression of CD1d and that of a known prognostic marker, CD38. CD1d expression was also positively correlated with the existence of secondary malignancies. Moreover, we determined a negative correlation between CD1d expression and time to treatment, as well as overall survival, in CLL patients. These correlations were valid for both the entire patient cohort and the treatment-naïve group. Finally, we determined cut-off values for CD1d MFI, thus dividing the patients into subgroups with either favorable or dismal prognosis.The aforementioned findings suggest that CD1d expression can assist the solution of problems in differential diagnosis between CLL and MCL, as well as SMZL and LPL. They also constitute CD1d a novel prognostic marker for CLL.

Το CD1d είναι ένα…

Subjects/Keywords: CD1d-NKT λεμφοκύτταρα; Λεμφοϋπερπλαστικά σύνδρομα; CD1d-NKT lymphocytes; Lymphoproliferative disorders

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APA (6th Edition):

Anastasiadis, A. (2013). Μελέτη του ανοσορρυθμιστικού άξονα ΝΚΤ λεμφοκυττάρων - CD1d στα λεμφοϋπερπλαστικά σύνδρομα. (Thesis). Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ). Retrieved from http://hdl.handle.net/10442/hedi/30074

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Anastasiadis, Athanasios. “Μελέτη του ανοσορρυθμιστικού άξονα ΝΚΤ λεμφοκυττάρων - CD1d στα λεμφοϋπερπλαστικά σύνδρομα.” 2013. Thesis, Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ). Accessed July 19, 2019. http://hdl.handle.net/10442/hedi/30074.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Anastasiadis, Athanasios. “Μελέτη του ανοσορρυθμιστικού άξονα ΝΚΤ λεμφοκυττάρων - CD1d στα λεμφοϋπερπλαστικά σύνδρομα.” 2013. Web. 19 Jul 2019.

Vancouver:

Anastasiadis A. Μελέτη του ανοσορρυθμιστικού άξονα ΝΚΤ λεμφοκυττάρων - CD1d στα λεμφοϋπερπλαστικά σύνδρομα. [Internet] [Thesis]. Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ); 2013. [cited 2019 Jul 19]. Available from: http://hdl.handle.net/10442/hedi/30074.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Anastasiadis A. Μελέτη του ανοσορρυθμιστικού άξονα ΝΚΤ λεμφοκυττάρων - CD1d στα λεμφοϋπερπλαστικά σύνδρομα. [Thesis]. Democritus University of Thrace (DUTH); Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ); 2013. Available from: http://hdl.handle.net/10442/hedi/30074

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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