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1.
Sierocki, Pierre.
Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs.
Degree: Docteur es, Chimie organique, 2019, Nantes
URL: http://www.theses.fr/2019NANT4075
► Les virus dits émergents sont aujourd’hui responsables de crises sanitaires majeures, en témoignent les récentes épidémies d’Ebola, de Chikungunya, ou du virus de la grippe…
(more)
▼ Les virus dits émergents sont aujourd’hui responsables de crises sanitaires majeures, en témoignent les récentes épidémies d’Ebola, de Chikungunya, ou du virus de la grippe A (H1N1). Des traitements antiviraux efficaces et sûrs sont donc toujours d’intérêt majeur. Au cours des dernières décennies, les analogues de nucléosides se sont révélés être de précieux alliés dans la lutte contre de nombreuses pathologies virales parmi lesquelles le virus du SIDA, celui de l’Hépatite C ou de l’Herpès.Récemment, le développement de C-nucléosides, présentant une position anomérique quaternaire, a permis d’obtenir des résultats prometteurs contre ces «nouveaux» virus. Au cours de ces travaux de thèse, réalisés en collaboration avec les laboratoires Janssen, nous avons mis au point de nouvelles voies d’accès à ces composés originaux, en exploitant la chimie des C-nucléosides. Une nouvelle famille d’analogues comportant les motifs 1,2,3-triazoleet cyano en position anomérique a notamment été préparée en utilisant la chimie “Click” et les couplages C-Cmétallo-catalysés.
As witnessed by recent Ebola, Chikungunya or Influenza (H1N1) breakthroughs, emerging an re-emerging viruses are still responsible for major health crisis. Efficient and safe antiviral therapies are thus highly needed. Over the past decades, nucleoside analogs have lead the fight against manyof those pathogens, including: HIV, HCV or HSV. Recently, C-nucleoside analogs bearing a quaternary anomericposition have emerged as promising antiviral drugs against these «new» viruses.There are still very few ways to access to such motif in the literature. In the course of this PhD thesis, collaborating with Janssen laboratories, we have developped new strategies to reach these originals scaffolds, relying on C-nucleosides chemistry. Notably, we have synthesized a familly ofanalogs, having a 1,2,3-triazole and a cyano group attheanomeric position, exploiting “Click” chemistry and metallo-catalyzed C-Ccouplings.
Advisors/Committee Members: Lebreton, Jacques (thesis director), Mathé-Allainmat, Monique (thesis director).
Subjects/Keywords: Couplages C-C
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APA (6th Edition):
Sierocki, P. (2019). Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs. (Doctoral Dissertation). Nantes. Retrieved from http://www.theses.fr/2019NANT4075
Chicago Manual of Style (16th Edition):
Sierocki, Pierre. “Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs.” 2019. Doctoral Dissertation, Nantes. Accessed March 01, 2021.
http://www.theses.fr/2019NANT4075.
MLA Handbook (7th Edition):
Sierocki, Pierre. “Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs.” 2019. Web. 01 Mar 2021.
Vancouver:
Sierocki P. Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs. [Internet] [Doctoral dissertation]. Nantes; 2019. [cited 2021 Mar 01].
Available from: http://www.theses.fr/2019NANT4075.
Council of Science Editors:
Sierocki P. Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs. [Doctoral Dissertation]. Nantes; 2019. Available from: http://www.theses.fr/2019NANT4075

Brno University of Technology
2.
Opatřil, Petr.
Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler.
Degree: 2019, Brno University of Technology
URL: http://hdl.handle.net/11012/52551
► The topic of this thesis is designing and realization of new programming language C+, implemented as extension of programming language C. Aside from that, comparison…
(more)
▼ The topic of this thesis is designing and realization of new programming language
C+, implemented as extension of programming language
C. Aside from that, comparison of several popular languages was conducted in order to discuss advantages and concept of the extension. Workings of compiler is explained, both theoretically and practically.
Advisors/Committee Members: Meduna, Alexandr (advisor), Soukup, Ondřej (referee).
Subjects/Keywords: rozšíření C; jazyk C; překladače; C+; C extension; C language; compilers; C+
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Opatřil, P. (2019). Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/52551
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Opatřil, Petr. “Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler.” 2019. Thesis, Brno University of Technology. Accessed March 01, 2021.
http://hdl.handle.net/11012/52551.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Opatřil, Petr. “Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler.” 2019. Web. 01 Mar 2021.
Vancouver:
Opatřil P. Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11012/52551.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Opatřil P. Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/52551
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology
3.
Opatřil, Petr.
Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler.
Degree: 2018, Brno University of Technology
URL: http://hdl.handle.net/11012/69558
► This thesis describes continuing development of new programming language C Plus conceived in earlier Bachelor’s Thesis oriented on enhancing C language with high level constructs…
(more)
▼ This thesis describes continuing development of new programming language
C Plus conceived in earlier Bachelor’s Thesis oriented on enhancing
C language with high level constructs with no additional cost. During development, several important languages were compared and
C Plus along with its grammar were expanded, advantages of additions were discussed and compared with solutions in other languages. Described enhancements were implemented in the compiler.
Advisors/Committee Members: Meduna, Alexandr (advisor), Kučera, Jiří (referee).
Subjects/Keywords: Jazyk C Plus; rozšíření C; překladače; C+; C Plus language; C extension; compilers; C+
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Opatřil, P. (2018). Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/69558
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Opatřil, Petr. “Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler.” 2018. Thesis, Brno University of Technology. Accessed March 01, 2021.
http://hdl.handle.net/11012/69558.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Opatřil, Petr. “Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler.” 2018. Web. 01 Mar 2021.
Vancouver:
Opatřil P. Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler. [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11012/69558.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Opatřil P. Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler. [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/69558
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
4.
Xu, Hongwei.
Mechanistic Consideration of C-C Bond Transformations at
Cobalt Complexes.
Degree: PhD, Chemistry, 2015, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:419447/
► The diamagnetic cobalt(III) dimethyl complex, cis,mer-(PMe3)3Co(CH3)2I, was found to promote selective C-C bond formation affording ethane and triplet (PMe3)3CoI. The mechanism of reductive elimination has…
(more)
▼ The diamagnetic cobalt(III) dimethyl complex,
cis,mer-(PMe3)3Co(CH3)2I, was found to promote selective
C-C bond
formation affording ethane and triplet (PMe3)3CoI. The mechanism of
reductive elimination has been investigated by a series of kinetic
and isotopic labeling experiments. Addition of free PMe3 or
coordinating solvent strongly inhibits reductive elimination,
indicating reversible phosphine dissociation prior to
C-C bond
coupling. In addition, both phosphine inhibition effect and chelate
flexibility experiment support one-phosphine dissociation pathway.
Radical trapping, isotopic crossover, and isotope effect
experiments were consistent with a proposed mechanism for ethane
extrusion where formation of a NMR observable five-coordinate
intermediate is followed by concerted
C-C bond formation and rapid
coordinate of free phosphine to generate resultant metal complex.
An intriguing spin crossover event and an unusual intermolecular
exchange of cobalt-methyl ligands were also observed during the
course of study of reductive elimination, and had been investigated
respectively. Based on in situ NMR experiment and a series of
kinetic data, the spin crossover was postulated to happen during
trimethylphosphine dissociation, which was the rate influencing
step in the overall reductive elimination process. The cobalt(III)
dimethyl halide complexes were found to undergo a degenerate
cobalt-to-cobalt transfer of the methyl ligands during isotopic
labeling experiments. Extensive mechanistic studies exclude
radical, methyl iodide elimination, and
disproportionation/comproportionation pathways for exchange of the
methyl groups between metals. A related cobalt(III) dimethyl
complex supported by the tridentate phosphine Me(CH2CH2PMe2)2
showed dramatically slower methyl ligand transfer, indicative of a
mechanism of intermetallic exchange with a requisite phosphine
dissociation. In the case of
C-CN bond study, a cobalt(I) methyl
species, (PMe3)4CoCH3, was found to promote
C-CN bond oxidative
addition of acetonitrile at ambient temperature. The isolated
product of acetonitrile activation was characterized by NMR, IR,
and single-crystal X-ray diffraction studies and presents a higher
valent metal in comparison to those previously observed for
base-metal-mediated nitrile activations. In addition to the above
chemistry, the reactivity of two novel cobalt(III) dimethyl
complexes had also been investigated.
Advisors/Committee Members: Bernskoetter, Wesley (Director), Williard, Paul (Reader), Kim, Eunsuk (Reader).
Subjects/Keywords: C-C bond coupling
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Xu, H. (2015). Mechanistic Consideration of C-C Bond Transformations at
Cobalt Complexes. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:419447/
Chicago Manual of Style (16th Edition):
Xu, Hongwei. “Mechanistic Consideration of C-C Bond Transformations at
Cobalt Complexes.” 2015. Doctoral Dissertation, Brown University. Accessed March 01, 2021.
https://repository.library.brown.edu/studio/item/bdr:419447/.
MLA Handbook (7th Edition):
Xu, Hongwei. “Mechanistic Consideration of C-C Bond Transformations at
Cobalt Complexes.” 2015. Web. 01 Mar 2021.
Vancouver:
Xu H. Mechanistic Consideration of C-C Bond Transformations at
Cobalt Complexes. [Internet] [Doctoral dissertation]. Brown University; 2015. [cited 2021 Mar 01].
Available from: https://repository.library.brown.edu/studio/item/bdr:419447/.
Council of Science Editors:
Xu H. Mechanistic Consideration of C-C Bond Transformations at
Cobalt Complexes. [Doctoral Dissertation]. Brown University; 2015. Available from: https://repository.library.brown.edu/studio/item/bdr:419447/

Oregon State University
5.
Zhang, Yong.
Some potential mechanisms for finely-tuned regulation of phospholipase C-β
isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate
activation.
Degree: PhD, Molecular and Cellular Biology, 2008, Oregon State University
URL: http://hdl.handle.net/1957/7451
► Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as…
(more)
▼ Phospholipase
C-β (PLC-β) isozymes are key effectors in G protein-coupled
signaling pathways. Prior research suggested that some isoforms of PLC-β may exist
and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation
assays of differentially-tagged PLC-β constructs and sizeexclusion
chromatography of native PLC-β support homodimerization of PLC-β3 and
PLC-β1 isozymes, but not heterodimerization of these isozymes. Size-exclusion
chromatography data also suggest that PLC-β3 and PLC-β1 form higher affinity
homodimers than PLC-β2. Evidence supportive of limited PLC-β monomerhomodimer
equilibrium appears at 100 nM and lower. Further assessment of
homodimerization status by co-immunoprecipitation assays with differentially-tagged
PLC-β3 fragments demonstrated that at least two subdomains of PLC-β3 are involved
in dimer formation, one in the catalytic X and Y domains, and the other in the G
protein-regulated carboxy-terminal domain. Additionally, microscopic fluorescence
resonance energy transfer assays provide evidence consistent with the existence of
PLC-β homodimers in a whole cell context.
Phosphatidylinositol 3,4,5-trisphosphate (PIP₃) has been proposed as a second
messenger that affects a variety of cellular responses. Previously, we had shown that
PLC-β1 and PLC-β3 bound immobilized PIP₃. In this study, PIP₃ was found to
potentiate Ca²⁺-stimulated PLC-β activities using an in vitro reconstitution assay.
LY294002, a specific PI 3-kinase inhibitor, significantly inhibited 10 minutes agoniststimulated
total IP accumulation. Both LY294002 and wortmannin inhibited 90
seconds agonist-stimulated IP₃ accumulation in intact cells. Moreover, transfected
p110CAAX, a constitutively activated PI 3-Kinase catalytic subunit, increased 90
seconds oxytocin-stimulated IP₃ accumulation. Receptor-ligand binding assays
indicated that LY294002 did not affect G protein-coupled receptors directly,
suggesting a physiological role for PIP₃ in directly potentiating PLC-β activity. When
co-expressed with p110CAAX, fluorescence-tagged PLC-β3 was increasingly
localized to the plasma membrane. Conversely, a greater proportion of PLC-β3
associated with cytosolic fraction following H9c2 cells treatment with LY294002.
Additional observations suggest that the
C-tail domain of PLC-β1 and β3, not the PH
or catalytic XY domain, is important for membrane association.
Advisors/Committee Members: Filtz, Theresa (advisor), Leid, Mark (committee member).
Subjects/Keywords: Phospholipase C beta; Phospholipase C
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Zhang, Y. (2008). Some potential mechanisms for finely-tuned regulation of phospholipase C-β
isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate
activation. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/7451
Chicago Manual of Style (16th Edition):
Zhang, Yong. “Some potential mechanisms for finely-tuned regulation of phospholipase C-β
isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate
activation.” 2008. Doctoral Dissertation, Oregon State University. Accessed March 01, 2021.
http://hdl.handle.net/1957/7451.
MLA Handbook (7th Edition):
Zhang, Yong. “Some potential mechanisms for finely-tuned regulation of phospholipase C-β
isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate
activation.” 2008. Web. 01 Mar 2021.
Vancouver:
Zhang Y. Some potential mechanisms for finely-tuned regulation of phospholipase C-β
isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate
activation. [Internet] [Doctoral dissertation]. Oregon State University; 2008. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1957/7451.
Council of Science Editors:
Zhang Y. Some potential mechanisms for finely-tuned regulation of phospholipase C-β
isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate
activation. [Doctoral Dissertation]. Oregon State University; 2008. Available from: http://hdl.handle.net/1957/7451

University of Minnesota
6.
Rondla, Naveen Reddy.
Development of new reaction methodologies using palladium catalysts.
Degree: PhD, Chemistry, 2014, University of Minnesota
URL: http://hdl.handle.net/11299/165789
► Chapter 1: This chapter provides a brief review of the chemistry of metal catalyzed C-C sigma-bond activation reactions. Literature examples for a variety of methods…
(more)
▼ Chapter 1: This chapter provides a brief review of the chemistry of metal catalyzed C-C sigma-bond activation reactions. Literature examples for a variety of methods to activate C-C sigma-bonds and their limitations are discussed in detail. Introduction to C-CN sigma-bond reaction and its advantages over the typical C-C sigma-bond activation reactions are discussed with literature examples. Motivation for the current work is also presented.Chapter 2: Presented herein development of new reaction methodology, intramolecular cyanoesterification of alkynes to synthesize highly functionalized butenolides. The reaction proceeds with commonly used palladium catalyst (Pd(PPh3)4) under microwave conditions in five minutes. The reaction tolerates wide variety of substrates and corresponding results are presented. Plausible mechanistic hypothesis is also discussed. Chapter 3: Presented herein new methodology for intramolecular cyanoacylation of alkenes to synthesize highly functionalized indanones . The major challenge of decarbonylation has been overcome using iminonitriles. The reaction proceeds in the presence of commonly used palladium catalyst (Pd(PPh3)4) and very common Lewis acid ZnCl2. The reaction tolerates wide variety of substrates and corresponding results are presented. Results of mechanistic study of the reaction and plausible mechanism are also presented.Chapter 4: Presented herein our attempt towards development of intramolecular azidocyanation of alkenes using carbamoyl azides. Interestingly instead of azidoacylation product, 2-quinazolinone was isolated by the loss of CH2 and N2. Future work on optimization and applications of this interesting reaction are discussed.
Subjects/Keywords: Catalysis; C-C Activation; Palladium
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Rondla, N. R. (2014). Development of new reaction methodologies using palladium catalysts. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/165789
Chicago Manual of Style (16th Edition):
Rondla, Naveen Reddy. “Development of new reaction methodologies using palladium catalysts.” 2014. Doctoral Dissertation, University of Minnesota. Accessed March 01, 2021.
http://hdl.handle.net/11299/165789.
MLA Handbook (7th Edition):
Rondla, Naveen Reddy. “Development of new reaction methodologies using palladium catalysts.” 2014. Web. 01 Mar 2021.
Vancouver:
Rondla NR. Development of new reaction methodologies using palladium catalysts. [Internet] [Doctoral dissertation]. University of Minnesota; 2014. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11299/165789.
Council of Science Editors:
Rondla NR. Development of new reaction methodologies using palladium catalysts. [Doctoral Dissertation]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/165789
7.
Walsh, Melissa Brietta.
The role of plastin in motor neuron diseases and identifying
genetic modifiers of spinal muscular atrophy.
Degree: PhD, Molecular Biology, Cell Biology, and
Biochemistry, 2015, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:419360/
► Abstract of The role of plastin in motor neuron disease and identifying genetic modifiers of spinal muscular atrophy, by Melissa B. Walsh, Ph. D., Brown…
(more)
▼ Abstract of The role of plastin in motor neuron
disease and identifying genetic modifiers of spinal muscular
atrophy, by Melissa B. Walsh, Ph. D., Brown University, May 2015.
Neurodegenerative diseases are becoming increasingly prevalent.
This growth in incidence correlates with a high demand for
treatment, which is not readily available for most of these
diseases. Identification of common genetic modifiers that affect
multiple diseases would enable a better understanding of the
mechanism of pathogenesis of these diseases and provide possible
therapeutic targets. Using the model system Caenorhabditis elegans
(
C. elegans) we assessed whether plastin, a previously identified
genetic modifier in patients of Spinal Muscular Atrophy (SMA), was
able to ameliorate the behavioral defects found in nematode models
of SMA, Amyotrophic Lateral Sclerosis (ALS) and polyglutamine
toxicity disease. Further genetic and biochemical screening was
done in order to understand how plastin acts to ameliorate SMA
defects. This study showed that plastin, an actin bundling protein
is able to suppress various behavioral defects across the three
disease models tested. It also identified the ortholog to
heterogeneous nuclear ribonucleoprotein F and H (hnRNP F and hnRNP
H) as a genetic modifier in
C. elegans models of SMA and ALS.
Analysis using a vertebrate neuronal system showed that SMN
co-immunoprecipitates with PLS3, hnRNP F and hnRNP H. Staining in
mouse primary motor neurons also shows a co-localization of SMN
with PLS3, hnRNP F and hnRNP H in motor neuron processes. The
genetic data in
C. elegans combined with the vertebrate protein
data suggest that SMN, PLS3 and hnRNP F/H could act in a complex
together in motor neuron processes that is pertinent to SMA
pathogenesis. Taken together, the identification of plastin and
hnRNP F/H as cross disease modifiers suggests that they could be
targeting a common mechanism perturbed in both diseases. Further
validation in vertebrate disease models is required and if true
would provide a novel therapeutic target for these
diseases.
Advisors/Committee Members: Hart, Anne (Director), Sahin, Mustafa (Reader), Reenan, Robert (Reader), Mowry, Kimberly (Reader), Morrow, Eric (Reader).
Subjects/Keywords: C. elegans
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Walsh, M. B. (2015). The role of plastin in motor neuron diseases and identifying
genetic modifiers of spinal muscular atrophy. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:419360/
Chicago Manual of Style (16th Edition):
Walsh, Melissa Brietta. “The role of plastin in motor neuron diseases and identifying
genetic modifiers of spinal muscular atrophy.” 2015. Doctoral Dissertation, Brown University. Accessed March 01, 2021.
https://repository.library.brown.edu/studio/item/bdr:419360/.
MLA Handbook (7th Edition):
Walsh, Melissa Brietta. “The role of plastin in motor neuron diseases and identifying
genetic modifiers of spinal muscular atrophy.” 2015. Web. 01 Mar 2021.
Vancouver:
Walsh MB. The role of plastin in motor neuron diseases and identifying
genetic modifiers of spinal muscular atrophy. [Internet] [Doctoral dissertation]. Brown University; 2015. [cited 2021 Mar 01].
Available from: https://repository.library.brown.edu/studio/item/bdr:419360/.
Council of Science Editors:
Walsh MB. The role of plastin in motor neuron diseases and identifying
genetic modifiers of spinal muscular atrophy. [Doctoral Dissertation]. Brown University; 2015. Available from: https://repository.library.brown.edu/studio/item/bdr:419360/

Vilnius Pedagogical University
8.
Jakštys,
Vytautas.
Trimačių vaizdų programavimas.
Degree: Master, Informatics, 2013, Vilnius Pedagogical University
URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130801_123349-60814
;
► Šiame darbe nagrinėjamos populiariausios trimačių vaizdų apdorojimo technologijos DirectX ir OpenGL. Buvo atlikta jų apžvalga, pateikti šių technologijų pagrindiniai privalumai ir trūkumai bei atlikta jų…
(more)
▼ Šiame darbe nagrinėjamos populiariausios
trimačių vaizdų apdorojimo technologijos DirectX ir OpenGL. Buvo
atlikta jų apžvalga, pateikti šių technologijų pagrindiniai
privalumai ir trūkumai bei atlikta jų lyginamoji analizė. Darbe
apžvelgtos populiariausios modernios programavimo kalbos turinčios
trimačių vaizdų programavimo galimybęs – C# ir C++. Panaudojant
šias kalbas buvo sukurta programinė įranga skirta DirectX ir OpenGL
technologijų vaizdų apdorojimo spartos tyrimui. Buvo atliktas
didelis skaičius eksperimentų, kurių metu buvo siekiama nustatyti
minėtų technologijų spartą vizualizuojant elementarių ir sudėtinių
figūrų judesius, bei taikant skirtingą figūrų gilumą. Atlikus
eksperimentinius tyrimus Windows aplinkoje buvo nustatyta, kad
DirectX technologijos trimačių vaizdų vizualizavimo sparta yra
didesnė. Ši savybė trimačių vaizdų vizualizavime kompiuteryje yra
svarbiausia ir ypač aktuali kompiuterinių žaidimų kūrime.
Greičiausiai DirectX technologija atvaizduoja trimačius vaizdus
programuojant juos C# kalba. Be to, ekperimetinių tyrimų metu buvo
nustatyta, kad DirectX technologija geriau išnaudoja CPU ir GPU
resursus. Taipogi darbe buvo sukurta taikomoji programa – trimatis
biliardo žaidimas, panaudojant efektyviausią trimačių vaizdų
apdorojimo technologiją DirectX ir programavimo kalbą
C#.
Three-dimensional rendering technologies
DirectX and OpenGL were reviewed in this work. The comprehensive
survey, review of advantages and disadvantages, and comparative
analysis of these technologies was done. The most popular modern
programmming languages with three-dimensional programming features
were reviewed in this work. The software for testing the speed of
the DirectX and OpenGL technologies was developed. A lot of
experiments were done in order to determinante speed of these
technologies. The experiments included vizualization of basic and
complex shapes movements, and different depth of the shapes. The
experimental investigations were performed in OS Windows and it was
determined that the speed of DirectX technology is higher. This
fact is the most important in three-dimensional rendering,
especially in computer games development. DirectX technology is the
fastest while programming in C#. Be to, ekperimetinių tyrimu metu
buvo nustatyta, kad DirectX technologija geriau išnaudoja CPU
išteklius. The application – three-dimensional biliard game was
developed in this work also. DirectX technology was used and It was
programmed in C#.
Advisors/Committee Members: Melnicenko, Grigorijus (Master’s thesis supervisor), Petkus, Tomas (Master’s thesis reviewer), Petkus, Tomas (Master’s degree committee member), Kazlauskas, Kazys (Master’s degree committee chair), Slivinskas, Vytautas (Master’s degree committee member), Dzemyda, Gintautas (Master’s degree committee member), Medvedev, Viktor (Master’s degree committee member).
Subjects/Keywords: DirectX; OpenGL; Programavimas; C#; C++; DirectX; OpenGL; Programming; C#; C++
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Jakštys,
Vytautas. (2013). Trimačių vaizdų programavimas. (Masters Thesis). Vilnius Pedagogical University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130801_123349-60814 ;
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Chicago Manual of Style (16th Edition):
Jakštys,
Vytautas. “Trimačių vaizdų programavimas.” 2013. Masters Thesis, Vilnius Pedagogical University. Accessed March 01, 2021.
http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130801_123349-60814 ;.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
MLA Handbook (7th Edition):
Jakštys,
Vytautas. “Trimačių vaizdų programavimas.” 2013. Web. 01 Mar 2021.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
Jakštys,
Vytautas. Trimačių vaizdų programavimas. [Internet] [Masters thesis]. Vilnius Pedagogical University; 2013. [cited 2021 Mar 01].
Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130801_123349-60814 ;.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Council of Science Editors:
Jakštys,
Vytautas. Trimačių vaizdų programavimas. [Masters Thesis]. Vilnius Pedagogical University; 2013. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130801_123349-60814 ;
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vilnius Pedagogical University
9.
Varkavičius,
Simonas.
Duomenų bazių programavimas C#
kalba.
Degree: Master, Informatics, 2014, Vilnius Pedagogical University
URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140724_111543-14883
;
► Laikui einant informacijos srautai vis didėja, todėl reikia surasti patogų būdą ją saugoti ir apdoroti. Dėka tobulėjančių informacinių technologijų, informacijos saugojimo ir apdorojimo metodai taip…
(more)
▼ Laikui einant informacijos srautai vis
didėja, todėl reikia surasti patogų būdą ją saugoti ir apdoroti.
Dėka tobulėjančių informacinių technologijų, informacijos saugojimo
ir apdorojimo metodai taip pat turi galimybę tobulėti. Šiais
laikais įvairūs informacijos kiekiai gali būti saugomi ne tik
fizinėje formoje, bet ir elektroniniame pavidale. Tokiame pavidale
informacija gali būti sėkmingai administruojama, naudojant
administravimo programinę įrangą. Šiame darbe apžvelgsime C# ir C++
programavimo kalbų sukurtas (realizuotas) duomenų administravimo
programas bei programavimo kalbų potencialą kuriant analogišką
produkciją. Detaliau bus apžvelgiama C# programavimo kalba. Šis
darbas yra skiriamas asmenims, kurie domisi duomenų administravimo
programų kūrimu ir taikymo galimybėmis. Šio baigiamojo magistrinio
darbo tikslas - išanalizuoti duomenų bazių programavimo C# kalba
charakteristikas, sukuriant taikomųjų programų pavyzdžius ir
atliekant jų efektyvumo tyrimus, bei jas palyginti su C++ kalba.
Darbo uždaviniai: Susipažinti su duomenų bazių (DB) teorine dalimi.
Parengti C# duomenų bazių administravimo programas, taikant
skirtingas programavimo metodikas. Išanalizuoti programų veikimo
charakteristikas. Pasirinkus tinkamiausias C# programavimo
metodikas, parengti demonstracines programas. Palyginti parengtų C#
ir C++ programų rezultatyvumą. .
As time passed the flow of information is
growing so had to find a convenient way to store and handle, thanks
to the constant development of information technology, information
storage and processing methods have the opportunity to excel.
Nowadays, different amounts of information can be stored not only
in shape but also in electronic form. Such form may be successfully
managed using the administration software. In this work, review the
C# and C++ programming language created (realized), data
administration programs and the programming language’s potential
for the analog output. Retailers will be an overview of the C#
programming language. This work is given to individuals who are
interested in database administration and application programming
development opportunities. This master thesis is to analyze the
database programming in C# language features, creating a sample
application and the effectiveness of their research, and to compare
them with the C++ language. Tasks: Get familiar with the database
(DB) of the theoretical part. Develop a programming language, C#
database management applications using different programming
techniques. To analyze the performance characteristics of
applications. Selecting the best C# programming techniques to
develop demonstration programs. Comparison between the performance
of programs developed in C# and C++
languages.
Advisors/Committee Members: Slivinskas, Vytautas (Master’s thesis supervisor), Šimonytė, Virginija (Master’s thesis reviewer), Kazlauskas, Kazys (Master’s degree committee chair), Petkus, Tomas (Master’s degree committee member), Medvedev, Viktor (Master’s degree committee member), Dzemyda, Gintautas (Master’s degree committee member), Slivinskas, Vytautas (Master’s degree committee member), Stankevičienė, Eglė (Master’s degree session secretary).
Subjects/Keywords: C#; Duomenų bazės; DB; C++; C#; Database; DB; C++
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Varkavičius,
Simonas. (2014). Duomenų bazių programavimas C#
kalba. (Masters Thesis). Vilnius Pedagogical University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140724_111543-14883 ;
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Chicago Manual of Style (16th Edition):
Varkavičius,
Simonas. “Duomenų bazių programavimas C#
kalba.” 2014. Masters Thesis, Vilnius Pedagogical University. Accessed March 01, 2021.
http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140724_111543-14883 ;.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
MLA Handbook (7th Edition):
Varkavičius,
Simonas. “Duomenų bazių programavimas C#
kalba.” 2014. Web. 01 Mar 2021.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
Varkavičius,
Simonas. Duomenų bazių programavimas C#
kalba. [Internet] [Masters thesis]. Vilnius Pedagogical University; 2014. [cited 2021 Mar 01].
Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140724_111543-14883 ;.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Council of Science Editors:
Varkavičius,
Simonas. Duomenų bazių programavimas C#
kalba. [Masters Thesis]. Vilnius Pedagogical University; 2014. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140724_111543-14883 ;
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
10.
Mathieu-Rivet, Elodie.
Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals.
Degree: Docteur es, Sciences, technologie, santé. Biologie végétale, 2009, Université de Bordeaux Segalen
URL: http://www.theses.fr/2009BOR21654
► Au cours de cette étude, nous avons isolé 4 ADNc codant pour des protéines activatrices putatives de l'APC/C de tomate : SlCCS52A, SlCCS52B, SlCDC20-1, et…
(more)
▼ Au cours de cette étude, nous avons isolé 4 ADNc codant pour des protéines activatrices putatives de l'APC/C de tomate : SlCCS52A, SlCCS52B, SlCDC20-1, et SlCDC20-2. Des données obtenues par RT-qPCR et par hybridation in situ révèlent des profils d'expression différents au niveau tissulaire mais également au cours du développement du fruit de tomate, suggérant que différentes protéines activatrices pourraient assurer la modulation spatio-temporelle de l'activité de l'APC/C chez la tomate. De plus, les transcrits du gène SlCCS52A s'accumulent plus particulièrement dans le fruit durant la phase d'expansion cellulaire, tandis que les transcrits du gène SlCCS52B sont plutôt présents durant les premiers stades de développement, caractérisés par une forte activité de division cellulaire. Afin de préciser le rôle de SlCCS52A et SlCCS52B dans le contrôle du cycle cellulaire et de l'endocycle chez la tomate, ces gènes ont fait l'objet d'une étude fonctionnelle. La réduction de l'expression de SlCCS52A entraîne une réduction de la taille des fruits et de la taille cellulaire, qui s'accompagne d'une diminution du niveau de ploïdie. La surexpression de ce gène modifie la cinétique de développement des fruits. La mise en place de l'endocycle est retardée, mais l'augmentation de la ploïdie est plus rapide et la croissance relative du fruit est alors plus importante. Enfin, la réduction de l'expression de SlCCS52B entraîne une augmentation de l'expression de SlCCS52A au niveau des fruits, suggérant l'existence de mécanismes compensatoires. L'ensemble de ces résultats montrent que SlCCS52A est impliqué dans la mise en place de l'endoréduplication chez la tomate, et participe au contrôle de l'expansion cellulaire.
In this study, we have isolated 4 cDNAs encoding putative proteins activating the APC/C in tomato: SlCCS52A, SlCCS52B, SlCDC20-1, and SlCDC20-2. Data obtained by RT-qPCR and in situ hybridization revealed different expression profiles in tissues but also during the development of tomato fruit, suggesting that different activator proteins could provide the spatio-temporal modulation of the APC/C activity in tomato. In addition, the SlCCS52A transcripts accumulate especially in the fruit during the cell expansion phase, while transcripts of the SlCCS52B gene are rather present during the early stages of development, characterized by a high activity of cell divisions. To clarify the role of SlCCS52A and SlCCS52B in cell cycle control and endocycle in tomato, we performed a functional analysis of these genes. Reducing the expression of SlCCS52A leads to reduced fruit size and cell size, accompanied by a decrease in the level of ploidy. The overexpression of this gene alters the kinetics of fruit development. The establishment of endocycle is delayed, but the increase in ploidy is faster and the relative growth of the fruit is much more important then. Finally, the reduced expression of SlCCS52B leads to an increased expression of SlCCS52A in fruit, suggesting the existence of compensatory mechanisms. All these results show…
Advisors/Committee Members: Hernould, Michel (thesis director).
Subjects/Keywords: APC/C
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mathieu-Rivet, E. (2009). Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals. (Doctoral Dissertation). Université de Bordeaux Segalen. Retrieved from http://www.theses.fr/2009BOR21654
Chicago Manual of Style (16th Edition):
Mathieu-Rivet, Elodie. “Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals.” 2009. Doctoral Dissertation, Université de Bordeaux Segalen. Accessed March 01, 2021.
http://www.theses.fr/2009BOR21654.
MLA Handbook (7th Edition):
Mathieu-Rivet, Elodie. “Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals.” 2009. Web. 01 Mar 2021.
Vancouver:
Mathieu-Rivet E. Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals. [Internet] [Doctoral dissertation]. Université de Bordeaux Segalen; 2009. [cited 2021 Mar 01].
Available from: http://www.theses.fr/2009BOR21654.
Council of Science Editors:
Mathieu-Rivet E. Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals. [Doctoral Dissertation]. Université de Bordeaux Segalen; 2009. Available from: http://www.theses.fr/2009BOR21654

University of Debrecen
11.
Domokos, Péter.
Személyiség teszt windows-os alkalmazásba
.
Degree: DE – ATC – Agrárgazdasági és Vidékfejlesztési Kar, 2010, University of Debrecen
URL: http://hdl.handle.net/2437/97182
► Szakdolgozatom témájának kiválasztásához, az egyik kedvenc tantárgyam, az Alkalmazott Pszichológiai ismeretek nyújtottak segítséget. A személyiségtesztek nagyon felkeltették érdeklődésemet, amelynek feldolgozása nem egyszerű feladat. Erre próbálok…
(more)
▼ Szakdolgozatom témájának kiválasztásához, az egyik kedvenc tantárgyam, az
Alkalmazott Pszichológiai ismeretek nyújtottak segítséget. A személyiségtesztek nagyon
felkeltették érdeklődésemet, amelynek feldolgozása nem egyszerű feladat. Erre próbálok egy
egyszerű Windows-os alkalmazást fejleszteni, ami leegyszerűsíti egy adott témakör
feldolgozását.
A program elkészítéséhez a
C# programozási nyelvet választottam, mert nagyon jól
használható fejlesztésre, és szinte minden platformon megoldható a program futtatása.
Advisors/Committee Members: Várallyai, László (advisor).
Subjects/Keywords: C#;
programozás
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Domokos, P. (2010). Személyiség teszt windows-os alkalmazásba
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/97182
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Domokos, Péter. “Személyiség teszt windows-os alkalmazásba
.” 2010. Thesis, University of Debrecen. Accessed March 01, 2021.
http://hdl.handle.net/2437/97182.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Domokos, Péter. “Személyiség teszt windows-os alkalmazásba
.” 2010. Web. 01 Mar 2021.
Vancouver:
Domokos P. Személyiség teszt windows-os alkalmazásba
. [Internet] [Thesis]. University of Debrecen; 2010. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/2437/97182.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Domokos P. Személyiség teszt windows-os alkalmazásba
. [Thesis]. University of Debrecen; 2010. Available from: http://hdl.handle.net/2437/97182
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen
12.
Kányási, József Viktor.
Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása
.
Degree: DE – TEK – Informatikai Kar, 2011, University of Debrecen
URL: http://hdl.handle.net/2437/118531
A Haladó DBMS ismeretek 1 tantárgy gyakorlatán használt rendszer, amely megkönnyíti az oktató munkáját. A rendszer adatbázisának felépítését és a hozzá kapcsolódó alkalmazás ismertetését tartalmazza.
Advisors/Committee Members: Vágner, Anikó Szilvia (advisor).
Subjects/Keywords: adatbázis;
C#
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kányási, J. V. (2011). Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/118531
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kányási, József Viktor. “Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása
.” 2011. Thesis, University of Debrecen. Accessed March 01, 2021.
http://hdl.handle.net/2437/118531.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kányási, József Viktor. “Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása
.” 2011. Web. 01 Mar 2021.
Vancouver:
Kányási JV. Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása
. [Internet] [Thesis]. University of Debrecen; 2011. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/2437/118531.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kányási JV. Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása
. [Thesis]. University of Debrecen; 2011. Available from: http://hdl.handle.net/2437/118531
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen
13.
Mihucza, Bence.
.NET alapú határidő figyelő alkalmazás fejlesztése
.
Degree: DE – TEK – Informatikai Kar, 2014, University of Debrecen
URL: http://hdl.handle.net/2437/178563
A szakdolgozat egy határidő figyelő alkalmazás fejlesztését írja le. Az alkalmazás C# nyelven íródott. Az adatbázis-kezelő rendszer MSSQL volt. A dokumentum tartalmazza az adatbázis sémát, valamint az alkalmazás működésének leírását.
Advisors/Committee Members: Kósa, Márk (advisor).
Subjects/Keywords: .NET;
C#
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mihucza, B. (2014). .NET alapú határidő figyelő alkalmazás fejlesztése
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/178563
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mihucza, Bence. “.NET alapú határidő figyelő alkalmazás fejlesztése
.” 2014. Thesis, University of Debrecen. Accessed March 01, 2021.
http://hdl.handle.net/2437/178563.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mihucza, Bence. “.NET alapú határidő figyelő alkalmazás fejlesztése
.” 2014. Web. 01 Mar 2021.
Vancouver:
Mihucza B. .NET alapú határidő figyelő alkalmazás fejlesztése
. [Internet] [Thesis]. University of Debrecen; 2014. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/2437/178563.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mihucza B. .NET alapú határidő figyelő alkalmazás fejlesztése
. [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/178563
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne
14.
Johnson, Douglas Forsyth.
An epidemiological to immunological basis for a hepatitis C vaccine.
Degree: 2013, University of Melbourne
URL: http://hdl.handle.net/11343/37881
► Hepatitis C virus (HCV) is estimated to chronically infect 3% of the world's population [1, 2]. In Australia an estimated 221,000 are living with chronic…
(more)
▼ Hepatitis C virus (HCV) is estimated to chronically infect 3% of the world's population [1, 2]. In Australia an estimated 221,000 are living with chronic HCV infection with 10,000 new infections occurring each year, predominantly through injecting drug use (IDU) [2, 3]. Despite the implementation of risk reduction strategies and treatment regimes, HCV transmission rates remain high amongst at risk populations and underscores the pressing need for alternative strategies such as an effective HCV vaccine.
This thesis identified at risk populations within Australia that would benefit from an effective HCV vaccine. Subsequently, the immune responses elicited by HCV virus-like-particles (HCV VLPs) were evaluated in a murine model to assess their potential as an HCV vaccine candidate.
Firstly, a review of HCV notifications for Victoria, Australia was undertaken utilising surveillance data from the Victorian Department of Health and population estimates from the Australian Bureau of Statistics.
Total HCV notifications in Victoria between 2007 and 2011 have fallen from 2782 to 2370 cases (53.3 to 42.1 per 100,000 respectively). Interestingly HCV notifications rates in rural and metropolitan regions of Victoria were similar (46.97 and 44.05 per 100,000 respectively). In contrast HCV treatment rates in rural regions (7.4 - 7.9 per 100,000) were less than half that of metropolitan regions (17.6 - 18.5 per 100,000). Barriers and access to treatment particularly in rural areas need to be addressed as HCV treatment reduces transmission and secondary complications associated with chronic HCV infection. The review of HCV notifications also revealed IDU remains the greatest risk factor for HCV acquisition. Modelling suggests the introduction of an HCV vaccine, particularly in high risk groups such as seronegative IDUs, will have a substantial impact on the incidence of chronic HCV in the community [4-6].
Subsequently, a retrospective cohort study of 361 Australian travellers to Asia demonstrated travellers to endemic countries are also at risk of HCV infection and would benefit from a preventative vaccine. The incidence density of acute HCV infections in this cohort of travellers was 1.8 per 10,000 travel days. The study also identified the incidence density of HBV infection in non immune travellers was 2.19 per 10,000 travel days highlighting the need for both education and vaccination where available.
Finally, the immune responses elicited by HCV virus-like-particles in a murine model were evaluated. HCV VLPs were designed in order to elicit the breadth of immune responses that are associated with spontaneous clearance of HCV. HCV VLPs were produced in Huh 7 cells (a human hepatoma cell line) and were shown to bind, enter and mature murine dendritic cells. BALB/c mice vaccinated with HCV VLPs demonstrated the…
Subjects/Keywords: hepatitis C
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Johnson, D. F. (2013). An epidemiological to immunological basis for a hepatitis C vaccine. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/37881
Chicago Manual of Style (16th Edition):
Johnson, Douglas Forsyth. “An epidemiological to immunological basis for a hepatitis C vaccine.” 2013. Doctoral Dissertation, University of Melbourne. Accessed March 01, 2021.
http://hdl.handle.net/11343/37881.
MLA Handbook (7th Edition):
Johnson, Douglas Forsyth. “An epidemiological to immunological basis for a hepatitis C vaccine.” 2013. Web. 01 Mar 2021.
Vancouver:
Johnson DF. An epidemiological to immunological basis for a hepatitis C vaccine. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11343/37881.
Council of Science Editors:
Johnson DF. An epidemiological to immunological basis for a hepatitis C vaccine. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/37881

Ruhr Universität Bochum
15.
Schrader, Stefanie.
Die Rolle der Proteinkinase C für das
Carbachol-induzierte Ca2+-Signal in primären β-Zellen der
Maus.
Degree: 2009, Ruhr Universität Bochum
URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28029
► Die Regulation der Insulinfreisetzung in vivo ist ein komplexer Prozeß. Über unterschiedliche Mechanismen kommt es sowohl durch Aktivierung des PLC/IP3-als auch des c-AMP- Signaltransduktionsweges zu…
(more)
▼ Die Regulation der Insulinfreisetzung in vivo ist
ein komplexer Prozeß. Über unterschiedliche Mechanismen kommt es
sowohl durch Aktivierung des PLC/IP3-als auch des
c-AMP-
Signaltransduktionsweges zu einem Anstieg der [Ca2+]i. Dieser gilt
als zentrales intrazelluläres Signal für die Insulinfreisetzung.
Ziel der vorliegenden Arbeit war die molekulare Analyse der an der
Regulation des Calciumstoffwechsels beteiligten PKC-
Isoenzymformen. Die Dissektion der Signaltransduktionswege erfolgte
nach Aktivierung der PKC-Isoformen durch Acetylcholin am Modell der
isolierten β-Zelle der Maus. In den Versuchen konnte durch
Aktivierung und Inhibierung der PKC-Isoformen gezeigt werden, daß
insbesondere die konventionellen, calciumabhängigen PKC-Isoformen
eine zentrale Rolle für das Acetylcholin-induzierte Ca2+-Signal in
primären β-Zellen spielen.
Advisors/Committee Members: Medizin.
Subjects/Keywords: Proteinkinase C; Calcium; Acetylcholin; Phospholipase
C; Bauchspeicheldrüse
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Schrader, S. (2009). Die Rolle der Proteinkinase C für das
Carbachol-induzierte Ca2+-Signal in primären β-Zellen der
Maus. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28029
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Schrader, Stefanie. “Die Rolle der Proteinkinase C für das
Carbachol-induzierte Ca2+-Signal in primären β-Zellen der
Maus.” 2009. Thesis, Ruhr Universität Bochum. Accessed March 01, 2021.
http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28029.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Schrader, Stefanie. “Die Rolle der Proteinkinase C für das
Carbachol-induzierte Ca2+-Signal in primären β-Zellen der
Maus.” 2009. Web. 01 Mar 2021.
Vancouver:
Schrader S. Die Rolle der Proteinkinase C für das
Carbachol-induzierte Ca2+-Signal in primären β-Zellen der
Maus. [Internet] [Thesis]. Ruhr Universität Bochum; 2009. [cited 2021 Mar 01].
Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28029.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Schrader S. Die Rolle der Proteinkinase C für das
Carbachol-induzierte Ca2+-Signal in primären β-Zellen der
Maus. [Thesis]. Ruhr Universität Bochum; 2009. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28029
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Federal de Mato Grosso do Sul
16.
Tetila, Andyane Freitas.
Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C
.
Degree: 2011, Universidade Federal de Mato Grosso do Sul
URL: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/1847
► A infecção pelo vírus da hepatite C (HCV) não é rara em indivíduos infectados pelo vírus da imunodeficiência humana (HIV) e representa um importante problema…
(more)
▼ A infecção pelo vírus da hepatite
C (HCV) não é rara em indivíduos infectados pelo vírus da imunodeficiência humana (HIV) e representa um importante problema de saúde pública. Ambos os vírus compartilham as mesmas vias de transmissão através da via parenteral, sexual e vertical. Mundialmente, a prevalência da coinfecção HIV/HCV varia de 15 a 30%, enquanto que em usuários de drogas injetáveis, estes valores chegam a 90%. Já a prevalência de indivíduos HIV na população HCV é pouco conhecida. O objetivo deste estudo foi descrever as características clínico-epidemiológicas e os fatores associados à infecção pelo HIV em pacientes portadores da hepatite
C, atendidos nos serviços de Infectologia de Campo Grande. Foram estudados 123 pacientes portadores do HCV, dos quais 35 eram positivos para o HIV. Nesse grupo houve o predomínio do gênero masculino, cor parda e baixa escolaridade. A média de idade foi de 44,7 anos. Foi observado que a maioria dos pacientes coinfectados possui LT CD4+ > 350 células/mm³, carga viral positiva e diagnóstico tardio do HIV. O genótipo 1 do HCV foi o mais freqüente, seguido pelo 3. O genótipo 2 não foi encontrado em nenhum indivíduo. Os fatores independentemente associados à infecção pelo HIV nesses pacientes foram: possuir parceiro sexual infectado pelo HIV e o uso de drogas ilícitas em grupo. Esses dados confirmam a efetiva transmissão do HIV através da exposição sexual e reafirmam o uso de drogas ilícitas como grande potencial de risco para contrair o HIV.
Advisors/Committee Members: Paniago, Anamaria Mello Miranda (advisor).
Subjects/Keywords: HIV;
Coinfecção;
Coinfection;
Hepatite C;
Hepatitis C
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tetila, A. F. (2011). Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C
. (Thesis). Universidade Federal de Mato Grosso do Sul. Retrieved from http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/1847
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tetila, Andyane Freitas. “Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C
.” 2011. Thesis, Universidade Federal de Mato Grosso do Sul. Accessed March 01, 2021.
http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/1847.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tetila, Andyane Freitas. “Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C
.” 2011. Web. 01 Mar 2021.
Vancouver:
Tetila AF. Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C
. [Internet] [Thesis]. Universidade Federal de Mato Grosso do Sul; 2011. [cited 2021 Mar 01].
Available from: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/1847.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tetila AF. Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C
. [Thesis]. Universidade Federal de Mato Grosso do Sul; 2011. Available from: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/1847
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vilnius Pedagogical University
17.
Oleškevič,
Marek.
Programavimo kalbų naudojimo Lietuvos mokyklose
analizė.
Degree: Master, Informatics, 2014, Vilnius Pedagogical University
URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140723_101945-13824
;
► Šiame darbe yra apžvelgta programavimo kalbų istorija ir jų raida, pradedant nuo pačios pirmosios programos ir pirmosios programuotojos ir baigiant šiuolaikinėmis programavimo kalbomis. Taip pat…
(more)
▼ Šiame darbe yra apžvelgta programavimo kalbų
istorija ir jų raida, pradedant nuo pačios pirmosios programos ir
pirmosios programuotojos ir baigiant šiuolaikinėmis programavimo
kalbomis. Taip pat apžvelgiama programavimo kalbų filosofija ir jų
populiarumas šiuo metu, analizuojamos programų populiarumo
pasikeitimo tendencijos. Taip pat yra atlikti anketiniai ir
eksperimentiniai tyrimai, parodantys programavimo kalbų populiarumą
mokyklose, pateikti mokinių gebėjimų įvertinimai mokinantis
skirtingas programavimo kalbas. Mokyklinio kurso lygmenyje
išanalizuotos informacinių technologijų valstybiniame brandos
egzamine naudojamos programavimo kalbos, jų struktūra, sintaksė ir
galimybės.
This paper is an overview of the history of
programming languages and their evolution, starting from the
first program and the first programmer and ending with modern
programming languages. It also provides an overview of the
programming language and the philosophy of their popularity this
time, the popularity of the programs analyzed the change in trend.
There are also carried out the survey and experimental studies
demonstrating the popularity of programming languages in schools,
give students skills assessments in teaching different programming
languages. School-level course analysis of information technology
in the public examination of maturity used programming languages,
their structure, syntax and options.
Advisors/Committee Members: Kazlauskas, Kazys (Master’s degree committee chair), Stankevičienė, Eglė (Master’s degree session secretary), Petkus, Tomas (Master’s degree committee member), Medvedev, Viktor (Master’s degree committee member), Slivinskas, Vytautas (Master’s degree committee member), Dzemyda, Gintautas (Master’s degree committee member), Petkus, Tomas (Master’s thesis supervisor), Melničenko, Grigorijus (Master’s thesis reviewer).
Subjects/Keywords: C++; Pascal; Raida; C++; Pascal; Evoliution
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Oleškevič,
Marek. (2014). Programavimo kalbų naudojimo Lietuvos mokyklose
analizė. (Masters Thesis). Vilnius Pedagogical University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140723_101945-13824 ;
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Chicago Manual of Style (16th Edition):
Oleškevič,
Marek. “Programavimo kalbų naudojimo Lietuvos mokyklose
analizė.” 2014. Masters Thesis, Vilnius Pedagogical University. Accessed March 01, 2021.
http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140723_101945-13824 ;.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
MLA Handbook (7th Edition):
Oleškevič,
Marek. “Programavimo kalbų naudojimo Lietuvos mokyklose
analizė.” 2014. Web. 01 Mar 2021.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
Oleškevič,
Marek. Programavimo kalbų naudojimo Lietuvos mokyklose
analizė. [Internet] [Masters thesis]. Vilnius Pedagogical University; 2014. [cited 2021 Mar 01].
Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140723_101945-13824 ;.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Council of Science Editors:
Oleškevič,
Marek. Programavimo kalbų naudojimo Lietuvos mokyklose
analizė. [Masters Thesis]. Vilnius Pedagogical University; 2014. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140723_101945-13824 ;
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Oregon State University
18.
Kwon, Sun Hyung.
Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts.
Degree: MS, Pharmacy, 2008, Oregon State University
URL: http://hdl.handle.net/1957/7449
► The mechanisms by which the activities of phospholipase C-β (PLC-β) enzymes are negatively regulated have not been well defined. We used cardiac-derived rat myoblast H9c2…
(more)
▼ The mechanisms by which the activities of phospholipase
C-β (PLC-β) enzymes are
negatively regulated have not been well defined. We used cardiac-derived rat
myoblast H9c2 cells to investigate possible modes of regulation of PLC-β3 enzymes,
the only endogenous β isoform abundantly found in these cells. The PLC-β3
population in these cells was detected almost exclusively associated with membrane
with only trace amounts being cytosolic. H9c2 cells responded to vasopressin
stimulation through the PLC-β pathway in a concentration-dependent manner. Direct
activation of endogenous protein kinase
C (PKC) by phorbol 12-myristate 13-acetate
(PMA) significantly diminished vasopressin effects on PLC-β3-mediated PI
hydrolysis. However, phosphorylation of PLC-β3 at the Ser1105 residue, the widely
recognized primary phosphorylation site on PLC-β3, was not observed upon PKC
activation. Other possible mechanisms by which the agonist-stimulated PLC-β3
activity is modulated were also tested. Short-term or prolonged stimulation of these
cells with either vasopressin or stimulation of PKC by PMA did not promote
translocation or down-regulation of the PLC-β3 population within the time frame
tested. Our observations imply that in H9c2 cells, activated PLC-β3 enzymes may be
negatively regulated utilizing some other molecular mechanism not tested in this
study.
Advisors/Committee Members: Filtz, Theresa M (advisor), Ishmael, Jane E (committee member).
Subjects/Keywords: Phospholipase C-beta; Phospholipase C – Physiological effect
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kwon, S. H. (2008). Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/7449
Chicago Manual of Style (16th Edition):
Kwon, Sun Hyung. “Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts.” 2008. Masters Thesis, Oregon State University. Accessed March 01, 2021.
http://hdl.handle.net/1957/7449.
MLA Handbook (7th Edition):
Kwon, Sun Hyung. “Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts.” 2008. Web. 01 Mar 2021.
Vancouver:
Kwon SH. Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts. [Internet] [Masters thesis]. Oregon State University; 2008. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1957/7449.
Council of Science Editors:
Kwon SH. Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts. [Masters Thesis]. Oregon State University; 2008. Available from: http://hdl.handle.net/1957/7449

University of Debrecen
19.
Urbán, József.
C-glikozilezési reakciók tanulmányozása
.
Degree: DE – Természettudományi és Technológiai Kar – Kémiai Intézet, 2014, University of Debrecen
URL: http://hdl.handle.net/2437/191337
A 1-C szubsztituált glikálok palládium katalizált Heck-tipusú C-glikozilezési reakcióit végeztük. Elektron szívó csoportokat tartalmazó galaktál származékok C-glikozilezési reakcióit tanulmányoztuk.
Advisors/Committee Members: Juhász, László (advisor).
Subjects/Keywords: C-glikozilezési reakció;
1-C szubsztituált glikál
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Urbán, J. (2014). C-glikozilezési reakciók tanulmányozása
. (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/191337
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Urbán, József. “C-glikozilezési reakciók tanulmányozása
.” 2014. Thesis, University of Debrecen. Accessed March 01, 2021.
http://hdl.handle.net/2437/191337.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Urbán, József. “C-glikozilezési reakciók tanulmányozása
.” 2014. Web. 01 Mar 2021.
Vancouver:
Urbán J. C-glikozilezési reakciók tanulmányozása
. [Internet] [Thesis]. University of Debrecen; 2014. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/2437/191337.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Urbán J. C-glikozilezési reakciók tanulmányozása
. [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/191337
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

KTH
20.
DEHBAREZ, AHMAD AMIRI.
Utveckling av bokningssystem med .NET.
Degree: Information and Communication Technology (ICT), 2013, KTH
URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128546
► Examensarbetet har utförts åt det nystartade företaget Idop AB:s vägnar och har inneburit en vidareutveckling av ett befintligt webbaserad bokningssystem för det specifika företaget.…
(more)
▼ Examensarbetet har utförts åt det nystartade företaget Idop AB:s vägnar och har inneburit en vidareutveckling av ett befintligt webbaserad bokningssystem för det specifika företaget. Huvudsyftet har varit att leverera en webbaserad bokningskalender där uthyrare kan lägga ut sina objekt samtidigt som intressenter kan boka dessa objekt. Dessa objekt kan omfattas av till exempel lägenheter, stugor och så vidare. Då projektet kräver att utvecklare och kund har ett nära samarbete valdes Skalning Agil metod som är en Agil metod, för att bäst uppnå detta syfte. Utvecklingen utav bokningssystemet skedde i en .NET miljö där programmeringsspråket var C#. För datalagring hade företaget Idop valt SQL server och interaktion med databasen sker genom Entity Framework. Resultatet av projektet blev en bokningskalender där uthyraren lägger ut sina lediga objekt för uthyrning under specifika datum samt uppger pris för den lediga perioden. Även intressenterna har nu möjlighet att preliminär boka ett specifikt objekt vid önskat datum. I rapporten förekommer mer detaljerad beskrivning av ovanståendenämnda punkter samt slutsatsen av projektet.
This project has been carried out on the recently started company Idop AB's behalf and has led to a further development of an existing webbased booking system for the mentioned company. The main goal has been to deliver a web-based booking calendar where advertiser can place their items while stakeholders can book these items. These items may be subject to such houses, cottages and so on. The project requires developers and customers to work closely, Scaling Agile Methods which is an agile method, was chosen for this purpose in order to best achieve this aim. The development of the booking system was written in a .NET environment in which the programming language was C#. For database, the company Idop AB had chosen SQL server and for interaction with the database Entity Framework. The outcome of the project was an online based booking calendar where the owners outsource their vacant properties for rent during specific dates and report the prices for the vacant period. The stakeholders are now able to make a preliminary booking of a specific object at the desired date. The report present more detailed description of the above mentioned points and the conclusion of the project.
Subjects/Keywords: .Net; C#; SQL; .Net; C#; SQL
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
DEHBAREZ, A. A. (2013). Utveckling av bokningssystem med .NET. (Thesis). KTH. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128546
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
DEHBAREZ, AHMAD AMIRI. “Utveckling av bokningssystem med .NET.” 2013. Thesis, KTH. Accessed March 01, 2021.
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128546.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
DEHBAREZ, AHMAD AMIRI. “Utveckling av bokningssystem med .NET.” 2013. Web. 01 Mar 2021.
Vancouver:
DEHBAREZ AA. Utveckling av bokningssystem med .NET. [Internet] [Thesis]. KTH; 2013. [cited 2021 Mar 01].
Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128546.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
DEHBAREZ AA. Utveckling av bokningssystem med .NET. [Thesis]. KTH; 2013. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128546
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rice University
21.
Majeti, Deepak.
Portable Programming Models for Heterogeneous Platforms.
Degree: PhD, Engineering, 2015, Rice University
URL: http://hdl.handle.net/1911/88096
► With the end of Dennard scaling and emergence of dark silicon, the bets are high on heterogeneous architectures to achieve both application performance and energy…
(more)
▼ With the end of Dennard scaling and emergence of dark silicon, the bets are high on heterogeneous architectures to achieve both application performance and energy efficiency.
However, diversity in heterogeneous architectures poses severe programming challenges in terms of data layout, memory coherence, task partitioning, data distribution, and sharing of virtual addresses. Existing high-level programming languages are inadequate to address these new architectural features since they lack the necessary abstractions to address the challenges mentioned above.
It is necessary for existing languages to be extended minimally with high-level constructs while maintaining existing standards of portability, performance, and productivity. The compiler and runtime together must efficiently map these constructs to a target architecture.
We develop Concord, a
C++ based programming model that extends the Intel Threading Building Blocks onto integrated heterogeneous CPU+GPU architectures that do not share the same virtual address between CPU and GPU. Concord supports many
C++ features including virtual functions. We implement Shared Virtual Memory to map applications with pointer intensive data structures onto heterogeneous architectures that do not share the same virtual address.
We introduce Heterogeneous Habanero-
C (H2C), an implementation of the Habanero execution model targeting modern heterogeneous architectures with multiple devices. H2C provides high-level constructs to specify the computation, communication and synchronization in a given application.
The H2C compiler and runtime frameworks efficiently map these high-level constructs onto the underlying heterogeneous hardware.
The highlights of H2C include: a data layout framework to generate code with best data layout suited for a given memory hierarchy; constructs to specify a task partition, leaving the complex analysis of determining the resultant data distribution to the compiler; and a unified event framework that allows a programmer to write applications with a macro data-flow model onto heterogeneous architectures.
Experimental results show Concord and H2C provide good portability, productivity, and performance. In the future, we believe heterogeneous architectures will be more diverse and
more pervasive. We believe programming systems like H2C and Concord that have a tight integration of language, compiler and runtime are the right way to target current and future heterogeneous systems.
Advisors/Committee Members: Sarkar, Vivek (advisor), Mellor-Crummey, John (committee member), Warburton, Timothy C (committee member), Barik, Rajkishore (committee member).
Subjects/Keywords: programming models; heterogeneous architectures; OpenCL; C++; C
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APA (6th Edition):
Majeti, D. (2015). Portable Programming Models for Heterogeneous Platforms. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/88096
Chicago Manual of Style (16th Edition):
Majeti, Deepak. “Portable Programming Models for Heterogeneous Platforms.” 2015. Doctoral Dissertation, Rice University. Accessed March 01, 2021.
http://hdl.handle.net/1911/88096.
MLA Handbook (7th Edition):
Majeti, Deepak. “Portable Programming Models for Heterogeneous Platforms.” 2015. Web. 01 Mar 2021.
Vancouver:
Majeti D. Portable Programming Models for Heterogeneous Platforms. [Internet] [Doctoral dissertation]. Rice University; 2015. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1911/88096.
Council of Science Editors:
Majeti D. Portable Programming Models for Heterogeneous Platforms. [Doctoral Dissertation]. Rice University; 2015. Available from: http://hdl.handle.net/1911/88096

University of Illinois – Urbana-Champaign
22.
Osberger, Thomas Joseph.
Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs.
Degree: PhD, Chemistry, 2016, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/92900
► Hydroxyamino acid motifs are well-represented structures in natural products and pharmaceuticals, and are widely employed as synthetic building blocks in organic synthesis. In nature, such…
(more)
▼ Hydroxyamino acid motifs are well-represented structures in natural products and pharmaceuticals, and are widely employed as synthetic building blocks in organic synthesis. In nature, such compounds are often synthesized via enzymatic
C-H oxidation of simple amino acid precursors. Inspired by such processes, small molecule catalysts have been developed to perform a variety of
C-H oxidation reactions, which have increased the efficiency of synthetic routes and allowed for late-stage diversification of complex molecules. This work describes the development and application of two transition metal catalyzed
C-H oxidation reactions for the synthesis and diversification of hydroxyamino acids and related molecules.
α-Hydroxy-β-amino acids are an important subclass of the hydroxyamino acid family, examples of which are found in pharmaceutical agents including taxol and bestatin. Current synthetic methods for the construction of these molecules often rely on the use of pre-oxidized fragments or harsh reagents. This work reports the merging of Brønsted acid catalysis with Pd(II)/bis-sulfoxide catalyzed allylic
C-H oxidation to achieve the synthesis of vinyl-oxazolidinones from simple homoallylic, N-Boc protected amines. It is shown that utilization of dibutylphosphate as a co-catalyst with a Pd(II)/bis-sulfoxide catalyst produces optimal reactivity, affording anti¬-vinyl-oxazolidinones. These products are versatile synthetic intermediates, and their synthetic derivatization into α-hydroxy-β-amino acids as well as intermediates to amino sugars is demonstrated. Furthermore, the high functional group tolerance of the reaction enabled late-stage cyclization on a leucine-β-allylglycine dipeptide substrate to install a vinyl oxazolidinone moiety. Mechanistic investigations into the role of the dibutylphosphate co-catalyst revealed that it may play multiple roles beyond promoting formation of a cationic π-allylPd intermediate, including serving as an anionic ligand to palladium capable of performing allylic
C-H cleavage.
Natural products of nonribosomal peptide synthetase (NRPS) origin posses complex topologies and diverse functional group arrays that lead to varied and impressive therapeutic potential. The structural diversity achieved among these natural products is due in large part to a biosynthetic strategy that employs pre- and post-assembly oxidative modifications of individual amino acid building blocks and fully assembled peptide chains, exemplified in the biosynthesis of vancomycin. In many cases, diversification is achieved via enzymatic hydroxylation of amino acids to form unnatural amino acids that are incorporated into a larger peptide structure, or are intermediates for further diversification of an amino acid. Here we report a strategy inspired by the elegant approach of NRPS biosynthetic systems, wherein small molecule iron catalysts Fe(PDP) and Fe(CF3PDP) enable the oxidative diversification of amino acids and peptides. In particular, a highly chemoselective hydroxylation at C5 of proline residues produces…
Advisors/Committee Members: White, M. Christina (advisor), White, M. Christina (Committee Chair), Denmark, Scott E (committee member), Katzenellenbogen, John A (committee member), van der Donk, WIlfred A (committee member).
Subjects/Keywords: C-H Functionalization; C-H Oxidation; Catalysis
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Osberger, T. J. (2016). Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/92900
Chicago Manual of Style (16th Edition):
Osberger, Thomas Joseph. “Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs.” 2016. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed March 01, 2021.
http://hdl.handle.net/2142/92900.
MLA Handbook (7th Edition):
Osberger, Thomas Joseph. “Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs.” 2016. Web. 01 Mar 2021.
Vancouver:
Osberger TJ. Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2016. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/2142/92900.
Council of Science Editors:
Osberger TJ. Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2016. Available from: http://hdl.handle.net/2142/92900
23.
Berges, Julien.
Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free.
Degree: Docteur es, Ingénierie Moléculaire, 2016, Montpellier, Ecole nationale supérieure de chimie
URL: http://www.theses.fr/2016ENCM0014
► Le sujet de cette thèse se situe dans le cadre général des arylations de nucléophiles catalysées par des complexes de métaux de transitions (Cu, Fe)…
(more)
▼ Le sujet de cette thèse se situe dans le cadre général des arylations de nucléophiles catalysées par des complexes de métaux de transitions (Cu, Fe) ou réalisées en absence de ces derniers, dans des conditions compétitives et respectueuses de l’environnement. Ces réactions sont d’une importance majeure pour l’industrie chimique. Dans un premier chapitre est tout d’abord décrit un couplage inédit mettant en jeu un sel d’aryldiazonium et un nucléophile azoté (formation de liaison CAr-N). La méthode procède dans des conditions douces via un système catalytique au cuivre peu coûteux et peu toxique. Les produits de couplage obtenus (Ar-NHet) sont d’un intérêt central dans l’industrie pharmaceutique et agrochimique. Dans une deuxième partie nous avons présenté une méthode permettant de réaliser le couplage entre des sels d’aryldiazonium et des dérivés du styrène, à l’aide d’un système t BuOK/DMF. Cette réaction, réalisée pour la première fois en absence de catalyseurs à base de métaux de transition, permet d’accéder, via la formation de liaisons CArsp²-Csp², à des motifs stilbènes variés qui trouvent de nombreuses applications en chimie pharmaceutique. Un deuxième chapitre porte sur l’utilisation de dérivés de l’iode hypervalent permettant la fonctionnalisation de noyaux aromatiques (C-H) ou de dérivés vinyliques (C-H). Une première méthode décrit une réaction de triflimidation directe de composés acétanilides avec une sélectivité exclusive en position para. Deux conditions réactionnelles ont été mises en place pour cette fonctionnalisation. Une première utilise une quantité stœchiométrique de PhI(OAc)2 et une autre utilise une quantité catalytique d’iodotoluène (génération in-situ de l’iode(III)). Cette transformation a conduit à la formation de liaisons CAr-N en présence de bis(trifluorométhane)sulfonimide de lithium (LINTf2) comme nucléophile azoté. Dans une deuxième partie, nous avons montré que l’iodure de bisphosphoranilidène (PNPI), pouvait catalyser la trifluorométhylation vinylique sélective de dérivés du styrène en présence d’un réactif de l’iode hypervalent (l’iode(III)), le réactif de Togni II. Des travaux sont en cours pour tenter de comprendre l’influence positive de l’utilisation de PNPI dans le cas de notre réaction. Un troisième chapitre décrit des résultats préliminaires permettant d’obtenir un rendement honorable (54%) lors du couplage catalysé au fer du 4-iodotoluène avec le phényllithium. Une autre série de test décrit le couplage entre des halogénures d’aryle et des alkyllithium primaires. La méthode semble très efficace, puisque par ailleurs les travaux très récents de la littérature pour des couplages similaires faisant intervenir les mêmes partenaires réactionnels, font appel à des catalyseurs de fer ou de palladium.
This thesis is part of a very general search seek to develop methodologies for environmentally sustainable conversion of small molecules into more valuable substances catalyzed by copper and iron complexes or under metal-free conditions. The work focuses on the functionalization of…
Advisors/Committee Members: Taillefer, Marc (thesis director).
Subjects/Keywords: Catalyse; Fer; Noyaux aromatiques; Cuivre; Liaisons C-N; C-O et C-C; Catalysis; Iron; Aromatics Rings; Copper; C-N; C-O and C-C bonds; 540
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Berges, J. (2016). Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free. (Doctoral Dissertation). Montpellier, Ecole nationale supérieure de chimie. Retrieved from http://www.theses.fr/2016ENCM0014
Chicago Manual of Style (16th Edition):
Berges, Julien. “Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free.” 2016. Doctoral Dissertation, Montpellier, Ecole nationale supérieure de chimie. Accessed March 01, 2021.
http://www.theses.fr/2016ENCM0014.
MLA Handbook (7th Edition):
Berges, Julien. “Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free.” 2016. Web. 01 Mar 2021.
Vancouver:
Berges J. Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free. [Internet] [Doctoral dissertation]. Montpellier, Ecole nationale supérieure de chimie; 2016. [cited 2021 Mar 01].
Available from: http://www.theses.fr/2016ENCM0014.
Council of Science Editors:
Berges J. Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free. [Doctoral Dissertation]. Montpellier, Ecole nationale supérieure de chimie; 2016. Available from: http://www.theses.fr/2016ENCM0014
24.
Calland, Noémie.
L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry.
Degree: Docteur es, Biochimie et biologie moléculaire, 2012, Université Lille II – Droit et Santé
URL: http://www.theses.fr/2012LIL2S031
► L’hépatite C est un problème majeur de santé publique qui touche environ 160 millions de personnes dans le monde. L’agent étiologique responsable de cette maladie,…
(more)
▼ L’hépatite
C est un problème majeur de santé publique qui touche environ 160 millions de personnes dans le monde. L’agent étiologique responsable de cette maladie, le virus de l’hépatite
C (HCV), est un petit virus enveloppé dont le génome est codé par un acide ribonucléique (ARN) simple brin de polarité positive. Actuellement, il n’existe aucun vaccin contre ce pathogène et les traitements utilisés sont insatisfaisants du fait de leur spécificité d’action limitée. Ainsi, afin d’établir une thérapie antivirale efficace évitant l’apparition et la sélection de mutants de résistance aux antiviraux, l’utilisation de plusieurs agents antiviraux ciblant directement la particule virale (direct acting antiviral agents ou DAAs) en combinaison est préconisée. C’est pourquoi la découverte de nouveaux DAAs à large spectre d’action ciblant diverses étapes du cycle viral infectieux est indispensable.Au cours de ma thèse, nous avons identifié un nouvel inhibiteur de l’entrée du HCV : l’épigallocatéchine-3-gallate (EGCG). Cette molécule, extraite du thé vert, inhibe l’infection des cellules par le HCV. Plus précisément, en utilisant des particules rétrovirales pseudotypées avec les glycoprotéines d’enveloppe E1 et E2 du HCV, nous avons démontré que cette catéchine naturelle, agit à une étape très précoce de l’entrée virale, indépendamment du génotype. De même, en nous servant du virus produit en culture cellulaire, nous avons montré que cette molécule agit directement sur la particule virale. Puis, par RT-PCR quantitative (quantitative real-time polymerase chain reaction), nous avons confirmé l’inhibition de la liaison du virus à la surface cellulaire, en présence d’EGCG. Par conséquent, nos travaux suggèrent que l’EGCG interagit avec la particule virale, probablement en se liant aux glycoprotéines d’enveloppe virales, bloquant ainsi une étape initiale d’attachement entre le virus et les facteurs cellulaires présents à la surface de l’hépatocyte. Puis, en inhibant la transmission libre du virus, à l’aide, soit d’agarose, soit d’anticorps neutralisants, nous avons démontré que l’EGCG inhibe la transmission du virus de cellule à cellule. Enfin, nous avons montré que l’EGCG élimine le virus présent dans le surnageant de culture cellulaire après quatre passages successifs sur des cellules naïves.La concentration d’EGCG nécessaire pour inhiber la moitié de l’infection virale (IC50) en culture cellulaire est 11 µM. Ainsi, afin d’identifier de nouvelles molécules présentant un mode d’action similaire à celui de l’EGCG et possédant une meilleure activité antivirale, nous avons sélectionnés différentes molécules naturelles et les avons testés pour leur potentiel effet anti-HCV. C’est ainsi que le chlorure de delphinidine, une anthocyanidine, a également été identifié en tant que nouvelle molécule inhibitrice de l’entrée du HCV. De même que l’EGCG, le chlorure de delphinidine cible directement la particule virale à une étape précoce de l’entrée, indépendamment du génotype, probablement en inhibant l’attachement du virus à la surface…
Advisors/Committee Members: Séron, Karin (thesis director).
Subjects/Keywords: EGCG; Delphinidine; Hépatite C; Hepatitis C virus
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Calland, N. (2012). L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry. (Doctoral Dissertation). Université Lille II – Droit et Santé. Retrieved from http://www.theses.fr/2012LIL2S031
Chicago Manual of Style (16th Edition):
Calland, Noémie. “L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry.” 2012. Doctoral Dissertation, Université Lille II – Droit et Santé. Accessed March 01, 2021.
http://www.theses.fr/2012LIL2S031.
MLA Handbook (7th Edition):
Calland, Noémie. “L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry.” 2012. Web. 01 Mar 2021.
Vancouver:
Calland N. L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry. [Internet] [Doctoral dissertation]. Université Lille II – Droit et Santé 2012. [cited 2021 Mar 01].
Available from: http://www.theses.fr/2012LIL2S031.
Council of Science Editors:
Calland N. L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry. [Doctoral Dissertation]. Université Lille II – Droit et Santé 2012. Available from: http://www.theses.fr/2012LIL2S031
25.
Kotsiri, Ioanna.
Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα.
Degree: 2016, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
URL: http://hdl.handle.net/10442/hedi/37543
► Summary: TGF-β1 is an important pre-fibrinogenic cytokine, which is produced by the non-parenchymal liver cells, activates the hepatic asteroid cells and has been involved in…
(more)
▼ Summary: TGF-β1 is an important pre-fibrinogenic cytokine, which is produced by the non-parenchymal liver cells, activates the hepatic asteroid cells and has been involved in the pathogenesis of liver fibrosis. For that reason, its role in the evolution of liver fibrosis has been studied for many years in patients with chronic hepatitis C (CHC) as well as with chronic hepatitis B. The purpose of this dissertation was to study the serum TGF-β1 levels, in association with liver fibrosis and to examine their change according to treatment response and their value as a predictive index in patients with CHC under antiviral treatment.Eighty four patients were included in the study (average age 46 years- old, 44 men, 40 women) with CHC belonging to all known HCV genotypes and were treated with pegylated interferon plus ribavirin. Liver fibrosis was estimated non-invasively with liver transient elastography. TGF-β1 levels were measured before and at the end of follow-up and 6 months after the completion of antiviral therapy using a standard immunoassay.TGF-β1 levels were not associated with epidemiological, biochemical or virological parameters. Univariate analysis showed association between antiviral treatment, age and white blood count, but not with the initial TGF-β1 levels. For patients with sustained virological response (SVR) TGF-β1 levels were significantly decreased at the end (12.327 pg/ml, p<0.0001) and 6 months after the completion of antiviral therapy (13.555 pg/ml, p=0.007) compared to baseline values (17.166 pg/ml), but not in patients showing relapse (11.487 vs 12.241 or 9.648 pg/ml, p=0.814 or p=0.344) or in patients showing non-response (16.319 vs 11.362 or 11.977 pg/ml, p=0.227 or p=0.695). There was no association between TGF-β1 and degree of liver fibrosis as estimated with transient elastography at baseline (p=0.29).In conclusion, our results shown that TGF-β1 displayed significant decrease in CHC patients with SVR to antiviral therapy. TGF-β1 levels are not associated with degree of liver fibrosis or to response to antiviral treatment.
ΠΕΡΙΛΗΨΗ: Ο TGF-β1 είναι μια σημαντική προ-ινωδογόνος κυτταροκίνη, παράγεται από τα μη παρεγχυματικά ηπατοκύτταρα, ενεργοποιεί τα ηπατικά αστεροειδή κύτταρα και έχει εμπλακεί στην παθογένεση της ηπατικής ίνωσης. Γι΄αυτό, ο ρόλος του στην εξέλιξη της ηπατικής ίνωσης έχει μελετηθεί για πολλά χρόνια, σε ασθενείς με χρόνια ηπατίτιδα C (CΗC) όσο και με χρόνια ηπατίτιδα B.Σκοπός της παρούσας διατριβής ήταν η μελέτη των επιπέδων του TGF-β1 στον ορό, η συσχέτισή τους με την ηπατική ίνωση, η μεταβολή τους ανάλογα με την ανταπόκριση στη θεραπεία, και η αξία του ως προγνωστικός δείκτης σε ασθενείς με χρόνια ηπατίτιδα C (CΗC) υπό αντιική θεραπεία.Στην μελέτη εντάχθηκαν 84 ασθενείς (μέση ηλικία 46 έτη, 44 άνδρες/40 γυναίκες) με ΧΗC όλων των γονοτύπων και τους χορηγήθηκε συνδυασμένη θεραπεία με πεγκυλιωμένη ιντερφερόνη και ριμπαβιρίνη. Η ηπατική ίνωση εκτιμήθηκε μη επεμβατικά με ελαστογραφία ήπατος. Τα επίπεδα του TGF-β1 στον ορό μετρήθηκαν πριν την έναρξη, στο τέλος και στους 6…
Subjects/Keywords: Χρόνια ηπατίτιδα C; Chronic hepatitis C
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kotsiri, I. (2016). Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/37543
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kotsiri, Ioanna. “Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα.” 2016. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed March 01, 2021.
http://hdl.handle.net/10442/hedi/37543.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kotsiri, Ioanna. “Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα.” 2016. Web. 01 Mar 2021.
Vancouver:
Kotsiri I. Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10442/hedi/37543.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kotsiri I. Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. Available from: http://hdl.handle.net/10442/hedi/37543
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
26.
Polydoros, Konstantinides.
Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D.
Degree: 2019, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
URL: http://hdl.handle.net/10442/hedi/46058
► Several studies have provided conflicting results regarding the immune responses in chronic hepatitis C (CHC) patients with mixed cryoglobulinemia (MC). The importance of B-cell activating…
(more)
▼ Several studies have provided conflicting results regarding the immune responses in chronic hepatitis C (CHC) patients with mixed cryoglobulinemia (MC). The importance of B-cell activating factor (BAFF) in MC has been described, but the role of interleukin (IL)-17A is less clear. Aim of the Study: The main objectives were to determine the levels of BAFF and IL-17A cytokines in patients with CHC with or without MC, and to investigate their kinetics during antiviral treatment with pegylated interferon-α/ribavirin and 6 months after the end of it. In addition, the aim was to evaluate the possible correlation of cytokines with vitD levels, the degree of hepatic fibrosis and the response to antiviral therapy. Furthermore, the results were correlated with demographic and laboratory data of the patients under study.Methods: Serum concentrations of IL-17A, BAFF and 25-OH vitamin D were measured in 34 CHC patients at baseline, end of treatment, and 6 months post-treatment with pegylated interferon-α and ribavirin, versus 12 healthy controls.Results: Thirty-four patients (20 male, mean age 40.7±9.2 years, 12 of genotype 1 or 4, 22 of genotype 2 or 3) were included, of whom 64.7% achieved a sustained virological response (SVR). MC was detected in 52.9% of the patients. Higher levels of both cytokines were found in patients with MC compared to those without. Patients who achieved SVR had higher pretreatment IL-17A and lower BAFF levels compared to those without SVR. IL-17A was downregulated during and following treatment in responders, whereas upregulation was observed in non-responders. CHC patients demonstrated low vitamin D levels compared to HC. Moreover, the changes in IL-17A over the treatment period were significantly associated with vitamin D changes (β=-0.04, SE=0.02, P=0.046). No difference in IL-17A, BAFF and vitamin D values was seen between patients with cirrhosis (n=14) and those without.Conclusions: CHC patients with asymptomatic MC have increased levels of IL-17A and BAFF. IL-17A levels decline significantly while BAFF increases during treatment in responders. An interplay between IL-17A and vitamin D concentrations was revealed during the antiviral treatment.Keywords: Interleukin 17A, B-cell activating factor, vitamin D, chronic hepatitis C, mixed cryoglobulinemia
Αρκετές μελέτες παρουσίασαν αντικρουόμενα αποτελέσματα σχετικά με τις ανοσολογικές αντιδράσεις σε ασθενείς με χρόνια ηπατίτιδα C (CHC) και μικτή κρυοσφαιριναιμία (MC). Η σημασία του ενεργοποιητικού παράγοντα των Β λεμφοκυττάρων (BAFF) στη MC έχει περιγραφεί προηγουμένως, αλλά ο ρόλος της ιντερλευκίνης (IL)-17A είναι λιγότερο σαφής. Σκοπός: Οι κύριοι στόχοι της παρούσας μελέτης ήταν ο προσδιορισμός των επιπέδων των κυτταροκινών BAFF και IL-17A σε ασθενείς που πάσχουν από CHC με ή χωρίς MC, και η διερεύνηση της κινητικής τους κατά τη διάρκεια της αντιιικής θεραπείας με pegIFN/RBV και 6 μήνες μετά το τέλος αυτής. Επιπρόσθετα, θέλαμε να αξιολογήσουμε τη σχέση των κυτταροκινών με τα επίπεδα της vitD, το βαθμό της ηπατικής ίνωσης και την ανταπόκριση στην…
Subjects/Keywords: Χρόνια ηπατίτιδα C; Chronic hepatitis C
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APA (6th Edition):
Polydoros, K. (2019). Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/46058
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Polydoros, Konstantinides. “Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D.” 2019. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed March 01, 2021.
http://hdl.handle.net/10442/hedi/46058.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Polydoros, Konstantinides. “Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D.” 2019. Web. 01 Mar 2021.
Vancouver:
Polydoros K. Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2019. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10442/hedi/46058.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Polydoros K. Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2019. Available from: http://hdl.handle.net/10442/hedi/46058
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
27.
Karamichali, Eirini.
Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C.
Degree: 2014, University of Patras; Πανεπιστήμιο Πατρών
URL: http://hdl.handle.net/10442/hedi/35595
► HCV infection is a major public health problem and a leading cause of chronic liver disease and hepatocellular carcinoma, with approximately 180 million infected individuals…
(more)
▼ HCV infection is a major public health problem and a leading cause of chronic liver disease and hepatocellular carcinoma, with approximately 180 million infected individuals worldwide. HCV is a positive sense RNA virus that belongs to the genus hepacivirus of the Flaviviridae family. Six major HCV genotypes (1–6) are known, each of which can be further subdivided into several subtypes (1a, 1b, 2a, etc). The HCV genome consists of a large open reading frame (ORF), flanked by highly structured 5’ and 3’ untranslated regions (UTRs). Both UTRs are conserved and control viral translation and replication. The HCV 5'-UTR contains an IRES that initiates cap-independent translation of the viral RNA. IRES-mediated translation of the HCV ORF yields a single polyprotein precursor that is co- and post-translationally processed by cellular and viral proteases, giving rise to mature structural and non structural proteins. Several studies have suggested that different cellular non canonical proteins or viral proteins can regulate the HCV IRES activity. The aim of this study was to understand the regulation of the HCV IRES dependent translation. Firstly, we tried to delineate the role of the viral proteins on HCV IRES dependent translation that still remains controversial. Clearly our studies demonstrated that HCV NS5A down-regulates IRES activity in a cell-type dependent manner. Additionally, we provide strong evidence that activated PKR up-regulates the IRES activity while silencing of endogenous PKR had the opposite effect. In addition, we concluded that the NS5A-mediated inhibitory effect on IRES-dependent translation was linked with the PKR inactivation. Moreover, as it is already reported that localised hypoxic areas are continuously present in HCC due to its high proliferation rate leading to an altered translation pattern, we investigated modulation of HCV IRES activity under low oxygen settings. Our results provided preliminary evidence that HCV-IRES-dependent translation is negatively regulated by low oxygen levels or under hypoxia-mimicking conditions in cell-specific manner.
H λοίμωξη που προκαλείται απο τον ιό της ηπατίτιδας C HCV είναι μείζον πρόβλημα για την δημόσια υγεία όπως επίσης και η κύρια αιτία της χρόνιας ηπατικής νόσου και ηπατοκυτταρικού καρκινώματος, με περίπου 180 εκατομμύρια μολυσμένα άτομα σε όλο τον κόσμο. Ο HCV είναι ένας RNA ιός θετικής πολικότητας που ανήκει στο γένος Hepacivirus της οικογένειας των Flaviviridae. Έξι γονότυποι ( 1-6 ) είναι γνωστοί, καθένας από τους οποίους μπορεί να υποδιαιρεθεί περαιτέρω σε αρκετές υποτύπους. Το γονιδίωμα του HCV αποτελείται από ένα μεγάλο ανοικτό πλαίσιο ανάγνωσης (ORF), πλαισιωμένο από ιδιαίτερα δομημένες 5 'και 3' αμετάφραστες περιοχές (UTRs). Και οι δύο περιοχές UTRs είναι συντηρημένες και έχουν τον έλεγχο της ιογενούς μετάφρασης και αναπαραγωγής. Το 5' UTR του HCV περιέχει μια περιοχή IRES απο την οποία γινεται η έναρξη της cap ανεξάρτητης μετάφρασης του ιικού RNA. Η HCV IRES εξαρτώμενη μετάφραση του ORF παράγει μια ενιαία πρόδρομη…
Subjects/Keywords: Ηπατίτιδα C, Ιός (HCV); Hepatitis C
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Karamichali, E. (2014). Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C. (Thesis). University of Patras; Πανεπιστήμιο Πατρών. Retrieved from http://hdl.handle.net/10442/hedi/35595
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Karamichali, Eirini. “Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C.” 2014. Thesis, University of Patras; Πανεπιστήμιο Πατρών. Accessed March 01, 2021.
http://hdl.handle.net/10442/hedi/35595.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Karamichali, Eirini. “Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C.” 2014. Web. 01 Mar 2021.
Vancouver:
Karamichali E. Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C. [Internet] [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2014. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10442/hedi/35595.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Karamichali E. Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C. [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2014. Available from: http://hdl.handle.net/10442/hedi/35595
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
28.
Mamede, Ana Catarina Manjolinha.
Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos.
Degree: 2010, RCAAP
URL: http://www.rcaap.pt/detail.jsp?id=oai:ubibliorum.ubi.pt:10400.6/2296
► A vitamina C é um nutriente essencial ao metabolismo das células vivas que existe sob duas formas: a forma reduzida (ácido ascórbico - AA) e…
(more)
▼ A vitamina C é um nutriente essencial ao metabolismo das células vivas que existe sob duas formas: a forma reduzida (ácido ascórbico - AA) e a forma oxidada (ácido dehidroascórbico – DHA). A vitamina C é um nutriente cujos benefícios são desde há muito tempo conhecidos e amplamente divulgados, sendo que a sua maioria se devem à acção antioxidante desta vitamina.
Como antioxidante, o principal papel da vitamina C é neutralizar os radicais livres doando-lhes os seus electrões, reflectindo a sua capacidade redutora e a habilidade para diminuir o stresse
oxidativo. No entanto, alguns estudos controversos sugerem que este nutriente possa ter um papel preventivo e terapêutico na doença oncológica devido à sua eventual actividade pró-oxidante,
promovendo a formação de espécies reactivas de oxigénio que podem induzir a morte celular nas
células cancerígenas. Este factor, aliado à diminuição das enzimas antioxidantes e ao aumento de metais de transição descompartimentalizados nas células tumorais poderá resultar na
citotoxicidade selectiva da vitamina C e na consequente revelação do seu potencial terapêutico.
O objectivo deste trabalho é estudar o metabolismo e os mecanismos de acção da forma
reduzida da vitamina C e mostrar o seu efeito citotóxico em duas linhas celulares tumorais:
adenocarcinoma colorectal (WiDr) e melanoma melanocítico (A-375). Para tal, usaram-se técnicas
de imagiologia nuclear e de biologia celular e molecular. Primeiramente, efectuou-se a marcação
da forma reduzida da vitamina C com tecnécio-99m, de forma a obter um complexo radioactivo
(99mTc-AA) passível de ser usado em imagiologia nuclear. Posteriormente, nos estudos in vitro,
procedeu-se à realização de estudos de captação de 99mTc-AA e de pertecnetato de sódio nas duas
linhas celulares estudadas, assim como à avaliação da citotoxicidade da vitamina através da
avaliação da proliferação celular por espectrofotometria, ensaios clonogénicos e citometria de fluxo.
Foram também feitos estudos in vivo com ratinhos Balb/c e Balb/c nu/nu com o intuito de
comprovar os resultados obtidos no controlo de qualidade do 99mTc-AA e obter informação sobre a
biodistribuição e vias de excreção e metabolização da formulação produzida. Por último, os
ratinhos com xenotransplantes foram submetidos a uma terapia com AA e os tumores excisados
foram analisados por citometria de fluxo. Os resultados obtidos sugerem que a forma reduzida da
vitamina C induz um efeito anti-proliferativo e/ou citotóxico nas células em estudo, podendo
eventualmente vir a constituir uma nova abordagem terapêutica no tratamento do cancro colorectal.
min C is an essential nutrient to the metabolism of living cells which exist in two forms:
the reduced form (ascorbic acid - AA) and oxidized form (dehydroascorbic acid - DHA). Vitamin C is
a nutrient whose benefits are long known and widely publicized, being most of them related to the
antioxidant action of this vitamin. As an antioxidant, the main role of vitamin C is neutralize free
radicals by donating their electrons to them, reflecting their…
Advisors/Committee Members: Botelho, Maria Filomena Rabaça Roque, Pereira, Jorge Manuel Maia, Abrantes, Ana Margarida Coelho.
Subjects/Keywords: Vitamina C; Vitamina C - Cancro; Ácido ascórbico; Vitamina C - Citotoxicidade; Vitamina C - Biodistribuição
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mamede, A. C. M. (2010). Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos. (Thesis). RCAAP. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:ubibliorum.ubi.pt:10400.6/2296
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mamede, Ana Catarina Manjolinha. “Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos.” 2010. Thesis, RCAAP. Accessed March 01, 2021.
http://www.rcaap.pt/detail.jsp?id=oai:ubibliorum.ubi.pt:10400.6/2296.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mamede, Ana Catarina Manjolinha. “Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos.” 2010. Web. 01 Mar 2021.
Vancouver:
Mamede ACM. Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos. [Internet] [Thesis]. RCAAP; 2010. [cited 2021 Mar 01].
Available from: http://www.rcaap.pt/detail.jsp?id=oai:ubibliorum.ubi.pt:10400.6/2296.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mamede ACM. Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos. [Thesis]. RCAAP; 2010. Available from: http://www.rcaap.pt/detail.jsp?id=oai:ubibliorum.ubi.pt:10400.6/2296
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah
29.
Garrone, Nicholas Felix.
Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain.
Degree: PhD, Human Genetics, 2010, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1258/rec/518
► A defining feature of NEDD4L protein isoforms is the presence or absence of an amino-terminal C2 domain, a class of subcellular, calcium-dependent targeting domains. We…
(more)
▼ A defining feature of NEDD4L protein isoforms is the presence or absence of an amino-terminal C2 domain, a class of subcellular, calcium-dependent targeting domains. We previously identified a common variant in human NEDD4L that generates isoforms that contain or lack a C2 domain. To address the potential functional significance of the NEDD4L common variant on NEDD4L subcellular localization, NEDD4L isoforms that either contained or lacked a C2 domain were tagged with enhanced green fluorescent protein, transfected into Xenopus laevis kidney epithelial cells, and imaged by performing confocal microscopy on live cells. We report that the presence or absence of this C2 domain exerts differential effects on the subcellular distribution of NEDD4L, the ability of C2 containing and lacking NEDD4L isoforms to mobilize in response to a calcium stimulus, and the intracellular transport of subunits of the NEDD4L substrate, ENaC. Furthermore, the ability of the C2-containing isoform to influence p-ENaC mobilization from intracellular pools involves the NEDD4L active site for ubiquitination. We propose a model to account for the potential impact of this common genetic variant on protein function at the cellular level. Additionally, to test in vivo the functional relevance of NEDD4L isoforms on sodium homeostasis and blood pressure we attempted to generate two gene targeted mice that would conditionally overexpress either NEDD4L isoform in the distal nephron. However, only the C2-lacking mouse was successfully generated so a comparative study between NEDD4L C2-containing and -lacking mice was not performed.
Subjects/Keywords: Protein Kinase C
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Garrone, N. F. (2010). Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1258/rec/518
Chicago Manual of Style (16th Edition):
Garrone, Nicholas Felix. “Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain.” 2010. Doctoral Dissertation, University of Utah. Accessed March 01, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1258/rec/518.
MLA Handbook (7th Edition):
Garrone, Nicholas Felix. “Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain.” 2010. Web. 01 Mar 2021.
Vancouver:
Garrone NF. Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Mar 01].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1258/rec/518.
Council of Science Editors:
Garrone NF. Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1258/rec/518

San Jose State University
30.
Varshney, Aruna.
Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition.
Degree: MS, Biological Sciences, 2012, San Jose State University
URL: https://doi.org/10.31979/etd.k8yd-csn3
;
https://scholarworks.sjsu.edu/etd_theses/4218
► Sensation and cognition are some of the fundamental human experiences. Our work aimed to understand the molecules responsible for the formation of proper neural…
(more)
▼ Sensation and cognition are some of the fundamental human experiences. Our work aimed to understand the molecules responsible for the formation of proper neural circuitry that underlies brain function. A critical step in process of neural circuit formation is the mechanism by which neurons recognize their correct synaptic partners from the many surrounding cells. This process is called synaptic partner recognition (SPR). We studied SPR in Caenhorabditis elegans, a nematode with a simple nervous system whose synapses share features with vertebrate synapses at the morphological and molecular level. Utilizing the transgenic fluorescent marker Neuroligin-1 GFP Reconstitution Across Synaptic Partners (NLG-1 GRASP), our group has previously discovered a gene that functions with UNC-6/Netrin and UNC-40/DCC in SPR. Animals with a mutation in this gene showed defective synaptogenesis between PHB sensory neurons and AVA interneurons. In this work, we showed PHB circuits were also functionally disrupted in these mutants, as they failed to sense sodium dodecyl sulfate (SDS), a noxious detergent. Moreover, epistasis results were consistent with a function downstream of UNC-6/Netrin, and expression in AVA neurons was sufficient to mediate SPR. Additionally, this gene is required for the establishment and maintenance of PHB-AVA synapses. Elucidating the molecular mechanism of SPR may help us to understand the logic of neural circuit formation and may also aid in the development of treatments for neurological disorders.
Subjects/Keywords: C. elegans; Synaptogenesis
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Varshney, A. (2012). Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition. (Masters Thesis). San Jose State University. Retrieved from https://doi.org/10.31979/etd.k8yd-csn3 ; https://scholarworks.sjsu.edu/etd_theses/4218
Chicago Manual of Style (16th Edition):
Varshney, Aruna. “Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition.” 2012. Masters Thesis, San Jose State University. Accessed March 01, 2021.
https://doi.org/10.31979/etd.k8yd-csn3 ; https://scholarworks.sjsu.edu/etd_theses/4218.
MLA Handbook (7th Edition):
Varshney, Aruna. “Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition.” 2012. Web. 01 Mar 2021.
Vancouver:
Varshney A. Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition. [Internet] [Masters thesis]. San Jose State University; 2012. [cited 2021 Mar 01].
Available from: https://doi.org/10.31979/etd.k8yd-csn3 ; https://scholarworks.sjsu.edu/etd_theses/4218.
Council of Science Editors:
Varshney A. Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition. [Masters Thesis]. San Jose State University; 2012. Available from: https://doi.org/10.31979/etd.k8yd-csn3 ; https://scholarworks.sjsu.edu/etd_theses/4218
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