subject:(C)

1. Sierocki, Pierre. Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs.

Degree: Docteur es, Chimie organique, 2019, Nantes

URL: http://www.theses.fr/2019NANT4075

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Les virus dits émergents sont aujourd’hui responsables de crises sanitaires majeures, en témoignent les récentes épidémies d’Ebola, de Chikungunya, ou du virus de la grippe… (more)

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Les virus dits émergents sont aujourd’hui responsables de crises sanitaires majeures, en témoignent les récentes épidémies d’Ebola, de Chikungunya, ou du virus de la grippe A (H1N1). Des traitements antiviraux efficaces et sûrs sont donc toujours d’intérêt majeur. Au cours des dernières décennies, les analogues de nucléosides se sont révélés être de précieux alliés dans la lutte contre de nombreuses pathologies virales parmi lesquelles le virus du SIDA, celui de l’Hépatite C ou de l’Herpès.Récemment, le développement de C-nucléosides, présentant une position anomérique quaternaire, a permis d’obtenir des résultats prometteurs contre ces «nouveaux» virus. Au cours de ces travaux de thèse, réalisés en collaboration avec les laboratoires Janssen, nous avons mis au point de nouvelles voies d’accès à ces composés originaux, en exploitant la chimie des C-nucléosides. Une nouvelle famille d’analogues comportant les motifs 1,2,3-triazoleet cyano en position anomérique a notamment été préparée en utilisant la chimie “Click” et les couplages C-Cmétallo-catalysés.

As witnessed by recent Ebola, Chikungunya or Influenza (H1N1) breakthroughs, emerging an re-emerging viruses are still responsible for major health crisis. Efficient and safe antiviral therapies are thus highly needed. Over the past decades, nucleoside analogs have lead the fight against manyof those pathogens, including: HIV, HCV or HSV. Recently, C-nucleoside analogs bearing a quaternary anomericposition have emerged as promising antiviral drugs against these «new» viruses.There are still very few ways to access to such motif in the literature. In the course of this PhD thesis, collaborating with Janssen laboratories, we have developped new strategies to reach these originals scaffolds, relying on C-nucleosides chemistry. Notably, we have synthesized a familly ofanalogs, having a 1,2,3-triazole and a cyano group attheanomeric position, exploiting “Click” chemistry and metallo-catalyzed C-Ccouplings.

Advisors/Committee Members: Lebreton, Jacques (thesis director), Mathé-Allainmat, Monique (thesis director).

Subjects/Keywords: Couplages C-C

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APA (6^th Edition):

Sierocki, P. (2019). Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs. (Doctoral Dissertation). Nantes. Retrieved from http://www.theses.fr/2019NANT4075

Chicago Manual of Style (16^th Edition):

Sierocki, Pierre. “Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs.” 2019. Doctoral Dissertation, Nantes. Accessed March 01, 2021. http://www.theses.fr/2019NANT4075.

MLA Handbook (7^th Edition):

Sierocki, Pierre. “Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs.” 2019. Web. 01 Mar 2021.

Vancouver:

Sierocki P. Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs. [Internet] [Doctoral dissertation]. Nantes; 2019. [cited 2021 Mar 01]. Available from: http://www.theses.fr/2019NANT4075.

Council of Science Editors:

Sierocki P. Synthèse de nouveaux analogues C-nucléoside quaternarisés en position anomérique comme agents antiviraux potentiels : C-nucleoside analogs bearing a quaternary carbon at the anomeric position as potential antiviral drugs. [Doctoral Dissertation]. Nantes; 2019. Available from: http://www.theses.fr/2019NANT4075

Brno University of Technology

2. Opatřil, Petr. Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler.

Degree: 2019, Brno University of Technology

URL: http://hdl.handle.net/11012/52551

► The topic of this thesis is designing and realization of new programming language C+, implemented as extension of programming language C. Aside from that, comparison… (more)

Subjects/Keywords: rozšíření C; jazyk C; překladače; C+; C extension; C language; compilers; C+

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APA (6^th Edition):

Opatřil, P. (2019). Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/52551

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Opatřil, Petr. “Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler.” 2019. Thesis, Brno University of Technology. Accessed March 01, 2021. http://hdl.handle.net/11012/52551.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Opatřil, Petr. “Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler.” 2019. Web. 01 Mar 2021.

Vancouver:

Opatřil P. Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/11012/52551.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Opatřil P. Rozšíření programovacího jazyka C a jeho překladače: An Extention of the C Programming Language and Its Compiler. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/52551

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

3. Opatřil, Petr. Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler.

Degree: 2018, Brno University of Technology

URL: http://hdl.handle.net/11012/69558

► This thesis describes continuing development of new programming language C Plus conceived in earlier Bachelor’s Thesis oriented on enhancing C language with high level constructs… (more)

Subjects/Keywords: Jazyk C Plus; rozšíření C; překladače; C+; C Plus language; C extension; compilers; C+

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APA (6^th Edition):

Opatřil, P. (2018). Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/69558

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Opatřil, Petr. “Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler.” 2018. Thesis, Brno University of Technology. Accessed March 01, 2021. http://hdl.handle.net/11012/69558.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Opatřil, Petr. “Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler.” 2018. Web. 01 Mar 2021.

Vancouver:

Opatřil P. Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler. [Internet] [Thesis]. Brno University of Technology; 2018. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/11012/69558.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Opatřil P. Rozšíření programovacího jazyka C Plus a jeho překladače: An Extension of the C Plus Programming Language and Its Compiler. [Thesis]. Brno University of Technology; 2018. Available from: http://hdl.handle.net/11012/69558

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

4. Xu, Hongwei. Mechanistic Consideration of C-C Bond Transformations at Cobalt Complexes.

Degree: PhD, Chemistry, 2015, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:419447/

► The diamagnetic cobalt(III) dimethyl complex, cis,mer-(PMe3)3Co(CH3)2I, was found to promote selective C-C bond formation affording ethane and triplet (PMe3)3CoI. The mechanism of reductive elimination has… (more)

▼ The diamagnetic cobalt(III) dimethyl complex, cis,mer-(PMe3)3Co(CH3)2I, was found to promote selective C-C bond formation affording ethane and triplet (PMe3)3CoI. The mechanism of reductive elimination has been investigated by a series of kinetic and isotopic labeling experiments. Addition of free PMe3 or coordinating solvent strongly inhibits reductive elimination, indicating reversible phosphine dissociation prior to C-C bond coupling. In addition, both phosphine inhibition effect and chelate flexibility experiment support one-phosphine dissociation pathway. Radical trapping, isotopic crossover, and isotope effect experiments were consistent with a proposed mechanism for ethane extrusion where formation of a NMR observable five-coordinate intermediate is followed by concerted C-C bond formation and rapid coordinate of free phosphine to generate resultant metal complex. An intriguing spin crossover event and an unusual intermolecular exchange of cobalt-methyl ligands were also observed during the course of study of reductive elimination, and had been investigated respectively. Based on in situ NMR experiment and a series of kinetic data, the spin crossover was postulated to happen during trimethylphosphine dissociation, which was the rate influencing step in the overall reductive elimination process. The cobalt(III) dimethyl halide complexes were found to undergo a degenerate cobalt-to-cobalt transfer of the methyl ligands during isotopic labeling experiments. Extensive mechanistic studies exclude radical, methyl iodide elimination, and disproportionation/comproportionation pathways for exchange of the methyl groups between metals. A related cobalt(III) dimethyl complex supported by the tridentate phosphine Me(CH2CH2PMe2)2 showed dramatically slower methyl ligand transfer, indicative of a mechanism of intermetallic exchange with a requisite phosphine dissociation. In the case of C-CN bond study, a cobalt(I) methyl species, (PMe3)4CoCH3, was found to promote C-CN bond oxidative addition of acetonitrile at ambient temperature. The isolated product of acetonitrile activation was characterized by NMR, IR, and single-crystal X-ray diffraction studies and presents a higher valent metal in comparison to those previously observed for base-metal-mediated nitrile activations. In addition to the above chemistry, the reactivity of two novel cobalt(III) dimethyl complexes had also been investigated. Advisors/Committee Members: Bernskoetter, Wesley (Director), Williard, Paul (Reader), Kim, Eunsuk (Reader).

Subjects/Keywords: C-C bond coupling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Xu, H. (2015). Mechanistic Consideration of C-C Bond Transformations at Cobalt Complexes. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:419447/

Chicago Manual of Style (16^th Edition):

Xu, Hongwei. “Mechanistic Consideration of C-C Bond Transformations at Cobalt Complexes.” 2015. Doctoral Dissertation, Brown University. Accessed March 01, 2021. https://repository.library.brown.edu/studio/item/bdr:419447/.

MLA Handbook (7^th Edition):

Xu, Hongwei. “Mechanistic Consideration of C-C Bond Transformations at Cobalt Complexes.” 2015. Web. 01 Mar 2021.

Vancouver:

Xu H. Mechanistic Consideration of C-C Bond Transformations at Cobalt Complexes. [Internet] [Doctoral dissertation]. Brown University; 2015. [cited 2021 Mar 01]. Available from: https://repository.library.brown.edu/studio/item/bdr:419447/.

Council of Science Editors:

Xu H. Mechanistic Consideration of C-C Bond Transformations at Cobalt Complexes. [Doctoral Dissertation]. Brown University; 2015. Available from: https://repository.library.brown.edu/studio/item/bdr:419447/

Oregon State University

5. Zhang, Yong. Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation.

Degree: PhD, Molecular and Cellular Biology, 2008, Oregon State University

URL: http://hdl.handle.net/1957/7451

► Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as… (more)

▼ Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled signaling pathways. Prior research suggested that some isoforms of PLC-β may exist and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation assays of differentially-tagged PLC-β constructs and sizeexclusion chromatography of native PLC-β support homodimerization of PLC-β3 and PLC-β1 isozymes, but not heterodimerization of these isozymes. Size-exclusion chromatography data also suggest that PLC-β3 and PLC-β1 form higher affinity homodimers than PLC-β2. Evidence supportive of limited PLC-β monomerhomodimer equilibrium appears at 100 nM and lower. Further assessment of homodimerization status by co-immunoprecipitation assays with differentially-tagged PLC-β3 fragments demonstrated that at least two subdomains of PLC-β3 are involved in dimer formation, one in the catalytic X and Y domains, and the other in the G protein-regulated carboxy-terminal domain. Additionally, microscopic fluorescence resonance energy transfer assays provide evidence consistent with the existence of PLC-β homodimers in a whole cell context. Phosphatidylinositol 3,4,5-trisphosphate (PIP₃) has been proposed as a second messenger that affects a variety of cellular responses. Previously, we had shown that PLC-β1 and PLC-β3 bound immobilized PIP₃. In this study, PIP₃ was found to potentiate Ca²⁺-stimulated PLC-β activities using an in vitro reconstitution assay. LY294002, a specific PI 3-kinase inhibitor, significantly inhibited 10 minutes agoniststimulated total IP accumulation. Both LY294002 and wortmannin inhibited 90 seconds agonist-stimulated IP₃ accumulation in intact cells. Moreover, transfected p110CAAX, a constitutively activated PI 3-Kinase catalytic subunit, increased 90 seconds oxytocin-stimulated IP₃ accumulation. Receptor-ligand binding assays indicated that LY294002 did not affect G protein-coupled receptors directly, suggesting a physiological role for PIP₃ in directly potentiating PLC-β activity. When co-expressed with p110CAAX, fluorescence-tagged PLC-β3 was increasingly localized to the plasma membrane. Conversely, a greater proportion of PLC-β3 associated with cytosolic fraction following H9c2 cells treatment with LY294002. Additional observations suggest that the C-tail domain of PLC-β1 and β3, not the PH or catalytic XY domain, is important for membrane association. Advisors/Committee Members: Filtz, Theresa (advisor), Leid, Mark (committee member).

Subjects/Keywords: Phospholipase C beta; Phospholipase C

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APA (6^th Edition):

Zhang, Y. (2008). Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/7451

Chicago Manual of Style (16^th Edition):

Zhang, Yong. “Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation.” 2008. Doctoral Dissertation, Oregon State University. Accessed March 01, 2021. http://hdl.handle.net/1957/7451.

MLA Handbook (7^th Edition):

Zhang, Yong. “Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation.” 2008. Web. 01 Mar 2021.

Vancouver:

Zhang Y. Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation. [Internet] [Doctoral dissertation]. Oregon State University; 2008. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1957/7451.

Council of Science Editors:

Zhang Y. Some potential mechanisms for finely-tuned regulation of phospholipase C-β isozymes : studies of dimerization and phosphatidylinositol 3,4,5-trisphosphate activation. [Doctoral Dissertation]. Oregon State University; 2008. Available from: http://hdl.handle.net/1957/7451

University of Minnesota

6. Rondla, Naveen Reddy. Development of new reaction methodologies using palladium catalysts.

Degree: PhD, Chemistry, 2014, University of Minnesota

URL: http://hdl.handle.net/11299/165789

► Chapter 1: This chapter provides a brief review of the chemistry of metal catalyzed C-C sigma-bond activation reactions. Literature examples for a variety of methods… (more)

Subjects/Keywords: Catalysis; C-C Activation; Palladium

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APA (6^th Edition):

Rondla, N. R. (2014). Development of new reaction methodologies using palladium catalysts. (Doctoral Dissertation). University of Minnesota. Retrieved from http://hdl.handle.net/11299/165789

Chicago Manual of Style (16^th Edition):

Rondla, Naveen Reddy. “Development of new reaction methodologies using palladium catalysts.” 2014. Doctoral Dissertation, University of Minnesota. Accessed March 01, 2021. http://hdl.handle.net/11299/165789.

MLA Handbook (7^th Edition):

Rondla, Naveen Reddy. “Development of new reaction methodologies using palladium catalysts.” 2014. Web. 01 Mar 2021.

Vancouver:

Rondla NR. Development of new reaction methodologies using palladium catalysts. [Internet] [Doctoral dissertation]. University of Minnesota; 2014. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/11299/165789.

Council of Science Editors:

Rondla NR. Development of new reaction methodologies using palladium catalysts. [Doctoral Dissertation]. University of Minnesota; 2014. Available from: http://hdl.handle.net/11299/165789

7. Walsh, Melissa Brietta. The role of plastin in motor neuron diseases and identifying genetic modifiers of spinal muscular atrophy.

Degree: PhD, Molecular Biology, Cell Biology, and Biochemistry, 2015, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:419360/

► Abstract of The role of plastin in motor neuron disease and identifying genetic modifiers of spinal muscular atrophy, by Melissa B. Walsh, Ph. D., Brown… (more)

▼ Abstract of The role of plastin in motor neuron disease and identifying genetic modifiers of spinal muscular atrophy, by Melissa B. Walsh, Ph. D., Brown University, May 2015. Neurodegenerative diseases are becoming increasingly prevalent. This growth in incidence correlates with a high demand for treatment, which is not readily available for most of these diseases. Identification of common genetic modifiers that affect multiple diseases would enable a better understanding of the mechanism of pathogenesis of these diseases and provide possible therapeutic targets. Using the model system Caenorhabditis elegans (C. elegans) we assessed whether plastin, a previously identified genetic modifier in patients of Spinal Muscular Atrophy (SMA), was able to ameliorate the behavioral defects found in nematode models of SMA, Amyotrophic Lateral Sclerosis (ALS) and polyglutamine toxicity disease. Further genetic and biochemical screening was done in order to understand how plastin acts to ameliorate SMA defects. This study showed that plastin, an actin bundling protein is able to suppress various behavioral defects across the three disease models tested. It also identified the ortholog to heterogeneous nuclear ribonucleoprotein F and H (hnRNP F and hnRNP H) as a genetic modifier in C. elegans models of SMA and ALS. Analysis using a vertebrate neuronal system showed that SMN co-immunoprecipitates with PLS3, hnRNP F and hnRNP H. Staining in mouse primary motor neurons also shows a co-localization of SMN with PLS3, hnRNP F and hnRNP H in motor neuron processes. The genetic data in C. elegans combined with the vertebrate protein data suggest that SMN, PLS3 and hnRNP F/H could act in a complex together in motor neuron processes that is pertinent to SMA pathogenesis. Taken together, the identification of plastin and hnRNP F/H as cross disease modifiers suggests that they could be targeting a common mechanism perturbed in both diseases. Further validation in vertebrate disease models is required and if true would provide a novel therapeutic target for these diseases. Advisors/Committee Members: Hart, Anne (Director), Sahin, Mustafa (Reader), Reenan, Robert (Reader), Mowry, Kimberly (Reader), Morrow, Eric (Reader).

Subjects/Keywords: C. elegans

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APA (6^th Edition):

Walsh, M. B. (2015). The role of plastin in motor neuron diseases and identifying genetic modifiers of spinal muscular atrophy. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:419360/

Chicago Manual of Style (16^th Edition):

Walsh, Melissa Brietta. “The role of plastin in motor neuron diseases and identifying genetic modifiers of spinal muscular atrophy.” 2015. Doctoral Dissertation, Brown University. Accessed March 01, 2021. https://repository.library.brown.edu/studio/item/bdr:419360/.

MLA Handbook (7^th Edition):

Walsh, Melissa Brietta. “The role of plastin in motor neuron diseases and identifying genetic modifiers of spinal muscular atrophy.” 2015. Web. 01 Mar 2021.

Vancouver:

Walsh MB. The role of plastin in motor neuron diseases and identifying genetic modifiers of spinal muscular atrophy. [Internet] [Doctoral dissertation]. Brown University; 2015. [cited 2021 Mar 01]. Available from: https://repository.library.brown.edu/studio/item/bdr:419360/.

Council of Science Editors:

Walsh MB. The role of plastin in motor neuron diseases and identifying genetic modifiers of spinal muscular atrophy. [Doctoral Dissertation]. Brown University; 2015. Available from: https://repository.library.brown.edu/studio/item/bdr:419360/

Vilnius Pedagogical University

8. Jakštys, Vytautas. Trimačių vaizdų programavimas.

Degree: Master, Informatics, 2013, Vilnius Pedagogical University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130801_123349-60814 ;

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Šiame darbe nagrinėjamos populiariausios trimačių vaizdų apdorojimo technologijos DirectX ir OpenGL. Buvo atlikta jų apžvalga, pateikti šių technologijų pagrindiniai privalumai ir trūkumai bei atlikta jų… (more)

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Šiame darbe nagrinėjamos populiariausios trimačių vaizdų apdorojimo technologijos DirectX ir OpenGL. Buvo atlikta jų apžvalga, pateikti šių technologijų pagrindiniai privalumai ir trūkumai bei atlikta jų lyginamoji analizė. Darbe apžvelgtos populiariausios modernios programavimo kalbos turinčios trimačių vaizdų programavimo galimybęs – C# ir C++. Panaudojant šias kalbas buvo sukurta programinė įranga skirta DirectX ir OpenGL technologijų vaizdų apdorojimo spartos tyrimui. Buvo atliktas didelis skaičius eksperimentų, kurių metu buvo siekiama nustatyti minėtų technologijų spartą vizualizuojant elementarių ir sudėtinių figūrų judesius, bei taikant skirtingą figūrų gilumą. Atlikus eksperimentinius tyrimus Windows aplinkoje buvo nustatyta, kad DirectX technologijos trimačių vaizdų vizualizavimo sparta yra didesnė. Ši savybė trimačių vaizdų vizualizavime kompiuteryje yra svarbiausia ir ypač aktuali kompiuterinių žaidimų kūrime. Greičiausiai DirectX technologija atvaizduoja trimačius vaizdus programuojant juos C# kalba. Be to, ekperimetinių tyrimų metu buvo nustatyta, kad DirectX technologija geriau išnaudoja CPU ir GPU resursus. Taipogi darbe buvo sukurta taikomoji programa – trimatis biliardo žaidimas, panaudojant efektyviausią trimačių vaizdų apdorojimo technologiją DirectX ir programavimo kalbą C#.

Three-dimensional rendering technologies DirectX and OpenGL were reviewed in this work. The comprehensive survey, review of advantages and disadvantages, and comparative analysis of these technologies was done. The most popular modern programmming languages with three-dimensional programming features were reviewed in this work. The software for testing the speed of the DirectX and OpenGL technologies was developed. A lot of experiments were done in order to determinante speed of these technologies. The experiments included vizualization of basic and complex shapes movements, and different depth of the shapes. The experimental investigations were performed in OS Windows and it was determined that the speed of DirectX technology is higher. This fact is the most important in three-dimensional rendering, especially in computer games development. DirectX technology is the fastest while programming in C#. Be to, ekperimetinių tyrimu metu buvo nustatyta, kad DirectX technologija geriau išnaudoja CPU išteklius. The application – three-dimensional biliard game was developed in this work also. DirectX technology was used and It was programmed in C#.

Advisors/Committee Members: Melnicenko, Grigorijus (Master’s thesis supervisor), Petkus, Tomas (Master’s thesis reviewer), Petkus, Tomas (Master’s degree committee member), Kazlauskas, Kazys (Master’s degree committee chair), Slivinskas, Vytautas (Master’s degree committee member), Dzemyda, Gintautas (Master’s degree committee member), Medvedev, Viktor (Master’s degree committee member).

Subjects/Keywords: DirectX; OpenGL; Programavimas; C#; C++; DirectX; OpenGL; Programming; C#; C++

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APA (6^th Edition):

Jakštys, Vytautas. (2013). Trimačių vaizdų programavimas. (Masters Thesis). Vilnius Pedagogical University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130801_123349-60814 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

Jakštys, Vytautas. “Trimačių vaizdų programavimas.” 2013. Masters Thesis, Vilnius Pedagogical University. Accessed March 01, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130801_123349-60814 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

Jakštys, Vytautas. “Trimačių vaizdų programavimas.” 2013. Web. 01 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Jakštys, Vytautas. Trimačių vaizdų programavimas. [Internet] [Masters thesis]. Vilnius Pedagogical University; 2013. [cited 2021 Mar 01]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130801_123349-60814 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

Jakštys, Vytautas. Trimačių vaizdų programavimas. [Masters Thesis]. Vilnius Pedagogical University; 2013. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130801_123349-60814 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vilnius Pedagogical University

9. Varkavičius, Simonas. Duomenų bazių programavimas C# kalba.

Degree: Master, Informatics, 2014, Vilnius Pedagogical University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140724_111543-14883 ;

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Laikui einant informacijos srautai vis didėja, todėl reikia surasti patogų būdą ją saugoti ir apdoroti. Dėka tobulėjančių informacinių technologijų, informacijos saugojimo ir apdorojimo metodai taip… (more)

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Laikui einant informacijos srautai vis didėja, todėl reikia surasti patogų būdą ją saugoti ir apdoroti. Dėka tobulėjančių informacinių technologijų, informacijos saugojimo ir apdorojimo metodai taip pat turi galimybę tobulėti. Šiais laikais įvairūs informacijos kiekiai gali būti saugomi ne tik fizinėje formoje, bet ir elektroniniame pavidale. Tokiame pavidale informacija gali būti sėkmingai administruojama, naudojant administravimo programinę įrangą. Šiame darbe apžvelgsime C# ir C++ programavimo kalbų sukurtas (realizuotas) duomenų administravimo programas bei programavimo kalbų potencialą kuriant analogišką produkciją. Detaliau bus apžvelgiama C# programavimo kalba. Šis darbas yra skiriamas asmenims, kurie domisi duomenų administravimo programų kūrimu ir taikymo galimybėmis. Šio baigiamojo magistrinio darbo tikslas - išanalizuoti duomenų bazių programavimo C# kalba charakteristikas, sukuriant taikomųjų programų pavyzdžius ir atliekant jų efektyvumo tyrimus, bei jas palyginti su C++ kalba. Darbo uždaviniai: Susipažinti su duomenų bazių (DB) teorine dalimi. Parengti C# duomenų bazių administravimo programas, taikant skirtingas programavimo metodikas. Išanalizuoti programų veikimo charakteristikas. Pasirinkus tinkamiausias C# programavimo metodikas, parengti demonstracines programas. Palyginti parengtų C# ir C++ programų rezultatyvumą. .

As time passed the flow of information is growing so had to find a convenient way to store and handle, thanks to the constant development of information technology, information storage and processing methods have the opportunity to excel. Nowadays, different amounts of information can be stored not only in shape but also in electronic form. Such form may be successfully managed using the administration software. In this work, review the C# and C++ programming language created (realized), data administration programs and the programming language’s potential for the analog output. Retailers will be an overview of the C# programming language. This work is given to individuals who are interested in database administration and application programming development opportunities. This master thesis is to analyze the database programming in C# language features, creating a sample application and the effectiveness of their research, and to compare them with the C++ language. Tasks: Get familiar with the database (DB) of the theoretical part. Develop a programming language, C# database management applications using different programming techniques. To analyze the performance characteristics of applications. Selecting the best C# programming techniques to develop demonstration programs. Comparison between the performance of programs developed in C# and C++ languages.

Advisors/Committee Members: Slivinskas, Vytautas (Master’s thesis supervisor), Šimonytė, Virginija (Master’s thesis reviewer), Kazlauskas, Kazys (Master’s degree committee chair), Petkus, Tomas (Master’s degree committee member), Medvedev, Viktor (Master’s degree committee member), Dzemyda, Gintautas (Master’s degree committee member), Slivinskas, Vytautas (Master’s degree committee member), Stankevičienė, Eglė (Master’s degree session secretary).

Subjects/Keywords: C#; Duomenų bazės; DB; C++; C#; Database; DB; C++

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Varkavičius, Simonas. (2014). Duomenų bazių programavimas C# kalba. (Masters Thesis). Vilnius Pedagogical University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140724_111543-14883 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

Varkavičius, Simonas. “Duomenų bazių programavimas C# kalba.” 2014. Masters Thesis, Vilnius Pedagogical University. Accessed March 01, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140724_111543-14883 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

Varkavičius, Simonas. “Duomenų bazių programavimas C# kalba.” 2014. Web. 01 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Varkavičius, Simonas. Duomenų bazių programavimas C# kalba. [Internet] [Masters thesis]. Vilnius Pedagogical University; 2014. [cited 2021 Mar 01]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140724_111543-14883 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

Varkavičius, Simonas. Duomenų bazių programavimas C# kalba. [Masters Thesis]. Vilnius Pedagogical University; 2014. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140724_111543-14883 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

10. Mathieu-Rivet, Elodie. Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals.

Degree: Docteur es, Sciences, technologie, santé. Biologie végétale, 2009, Université de Bordeaux Segalen

URL: http://www.theses.fr/2009BOR21654

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Au cours de cette étude, nous avons isolé 4 ADNc codant pour des protéines activatrices putatives de l'APC/C de tomate : SlCCS52A, SlCCS52B, SlCDC20-1, et… (more)

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Au cours de cette étude, nous avons isolé 4 ADNc codant pour des protéines activatrices putatives de l'APC/C de tomate : SlCCS52A, SlCCS52B, SlCDC20-1, et SlCDC20-2. Des données obtenues par RT-qPCR et par hybridation in situ révèlent des profils d'expression différents au niveau tissulaire mais également au cours du développement du fruit de tomate, suggérant que différentes protéines activatrices pourraient assurer la modulation spatio-temporelle de l'activité de l'APC/C chez la tomate. De plus, les transcrits du gène SlCCS52A s'accumulent plus particulièrement dans le fruit durant la phase d'expansion cellulaire, tandis que les transcrits du gène SlCCS52B sont plutôt présents durant les premiers stades de développement, caractérisés par une forte activité de division cellulaire. Afin de préciser le rôle de SlCCS52A et SlCCS52B dans le contrôle du cycle cellulaire et de l'endocycle chez la tomate, ces gènes ont fait l'objet d'une étude fonctionnelle. La réduction de l'expression de SlCCS52A entraîne une réduction de la taille des fruits et de la taille cellulaire, qui s'accompagne d'une diminution du niveau de ploïdie. La surexpression de ce gène modifie la cinétique de développement des fruits. La mise en place de l'endocycle est retardée, mais l'augmentation de la ploïdie est plus rapide et la croissance relative du fruit est alors plus importante. Enfin, la réduction de l'expression de SlCCS52B entraîne une augmentation de l'expression de SlCCS52A au niveau des fruits, suggérant l'existence de mécanismes compensatoires. L'ensemble de ces résultats montrent que SlCCS52A est impliqué dans la mise en place de l'endoréduplication chez la tomate, et participe au contrôle de l'expansion cellulaire.

In this study, we have isolated 4 cDNAs encoding putative proteins activating the APC/C in tomato: SlCCS52A, SlCCS52B, SlCDC20-1, and SlCDC20-2. Data obtained by RT-qPCR and in situ hybridization revealed different expression profiles in tissues but also during the development of tomato fruit, suggesting that different activator proteins could provide the spatio-temporal modulation of the APC/C activity in tomato. In addition, the SlCCS52A transcripts accumulate especially in the fruit during the cell expansion phase, while transcripts of the SlCCS52B gene are rather present during the early stages of development, characterized by a high activity of cell divisions. To clarify the role of SlCCS52A and SlCCS52B in cell cycle control and endocycle in tomato, we performed a functional analysis of these genes. Reducing the expression of SlCCS52A leads to reduced fruit size and cell size, accompanied by a decrease in the level of ploidy. The overexpression of this gene alters the kinetics of fruit development. The establishment of endocycle is delayed, but the increase in ploidy is faster and the relative growth of the fruit is much more important then. Finally, the reduced expression of SlCCS52B leads to an increased expression of SlCCS52A in fruit, suggesting the existence of compensatory mechanisms. All these results show…

Advisors/Committee Members: Hernould, Michel (thesis director).

Subjects/Keywords: APC/C

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mathieu-Rivet, E. (2009). Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals. (Doctoral Dissertation). Université de Bordeaux Segalen. Retrieved from http://www.theses.fr/2009BOR21654

Chicago Manual of Style (16^th Edition):

Mathieu-Rivet, Elodie. “Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals.” 2009. Doctoral Dissertation, Université de Bordeaux Segalen. Accessed March 01, 2021. http://www.theses.fr/2009BOR21654.

MLA Handbook (7^th Edition):

Mathieu-Rivet, Elodie. “Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals.” 2009. Web. 01 Mar 2021.

Vancouver:

Mathieu-Rivet E. Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals. [Internet] [Doctoral dissertation]. Université de Bordeaux Segalen; 2009. [cited 2021 Mar 01]. Available from: http://www.theses.fr/2009BOR21654.

Council of Science Editors:

Mathieu-Rivet E. Etude du rôle de l'activateur de l'APC/C CCS52 dans la transition du cycle mitotique vers l'endocycle au cours du développement du fruit de tomate (Solanum lycopersicum Mill.) : Acousto-optic couplings in photonic and phononic crystals. [Doctoral Dissertation]. Université de Bordeaux Segalen; 2009. Available from: http://www.theses.fr/2009BOR21654

University of Debrecen

11. Domokos, Péter. Személyiség teszt windows-os alkalmazásba .

Degree: DE – ATC – Agrárgazdasági és Vidékfejlesztési Kar, 2010, University of Debrecen

URL: http://hdl.handle.net/2437/97182

► Szakdolgozatom témájának kiválasztásához, az egyik kedvenc tantárgyam, az Alkalmazott Pszichológiai ismeretek nyújtottak segítséget. A személyiségtesztek nagyon felkeltették érdeklődésemet, amelynek feldolgozása nem egyszerű feladat. Erre próbálok… (more)

Subjects/Keywords: C#; programozás

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APA (6^th Edition):

Domokos, P. (2010). Személyiség teszt windows-os alkalmazásba . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/97182

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Domokos, Péter. “Személyiség teszt windows-os alkalmazásba .” 2010. Thesis, University of Debrecen. Accessed March 01, 2021. http://hdl.handle.net/2437/97182.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Domokos, Péter. “Személyiség teszt windows-os alkalmazásba .” 2010. Web. 01 Mar 2021.

Vancouver:

Domokos P. Személyiség teszt windows-os alkalmazásba . [Internet] [Thesis]. University of Debrecen; 2010. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2437/97182.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Domokos P. Személyiség teszt windows-os alkalmazásba . [Thesis]. University of Debrecen; 2010. Available from: http://hdl.handle.net/2437/97182

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

12. Kányási, József Viktor. Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása .

Degree: DE – TEK – Informatikai Kar, 2011, University of Debrecen

URL: http://hdl.handle.net/2437/118531

A Haladó DBMS ismeretek 1 tantárgy gyakorlatán használt rendszer, amely megkönnyíti az oktató munkáját. A rendszer adatbázisának felépítését és a hozzá kapcsolódó alkalmazás ismertetését tartalmazza. Advisors/Committee Members: Vágner, Anikó Szilvia (advisor).

Subjects/Keywords: adatbázis; C#

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APA (6^th Edition):

Kányási, J. V. (2011). Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/118531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kányási, József Viktor. “Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása .” 2011. Thesis, University of Debrecen. Accessed March 01, 2021. http://hdl.handle.net/2437/118531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kányási, József Viktor. “Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása .” 2011. Web. 01 Mar 2021.

Vancouver:

Kányási JV. Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása . [Internet] [Thesis]. University of Debrecen; 2011. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2437/118531.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kányási JV. Adatbázisos tárgyak beadandó feladatait ellenőrző szkriptek írása . [Thesis]. University of Debrecen; 2011. Available from: http://hdl.handle.net/2437/118531

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

13. Mihucza, Bence. .NET alapú határidő figyelő alkalmazás fejlesztése .

Degree: DE – TEK – Informatikai Kar, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/178563

A szakdolgozat egy határidő figyelő alkalmazás fejlesztését írja le. Az alkalmazás C# nyelven íródott. Az adatbázis-kezelő rendszer MSSQL volt. A dokumentum tartalmazza az adatbázis sémát, valamint az alkalmazás működésének leírását. Advisors/Committee Members: Kósa, Márk (advisor).

Subjects/Keywords: .NET; C#

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APA (6^th Edition):

Mihucza, B. (2014). .NET alapú határidő figyelő alkalmazás fejlesztése . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/178563

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mihucza, Bence. “.NET alapú határidő figyelő alkalmazás fejlesztése .” 2014. Thesis, University of Debrecen. Accessed March 01, 2021. http://hdl.handle.net/2437/178563.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mihucza, Bence. “.NET alapú határidő figyelő alkalmazás fejlesztése .” 2014. Web. 01 Mar 2021.

Vancouver:

Mihucza B. .NET alapú határidő figyelő alkalmazás fejlesztése . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2437/178563.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mihucza B. .NET alapú határidő figyelő alkalmazás fejlesztése . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/178563

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

14. Johnson, Douglas Forsyth. An epidemiological to immunological basis for a hepatitis C vaccine.

Degree: 2013, University of Melbourne

URL: http://hdl.handle.net/11343/37881

► Hepatitis C virus (HCV) is estimated to chronically infect 3% of the world's population [1, 2]. In Australia an estimated 221,000 are living with chronic… (more)

▼ Hepatitis C virus (HCV) is estimated to chronically infect 3% of the world's population [1, 2]. In Australia an estimated 221,000 are living with chronic HCV infection with 10,000 new infections occurring each year, predominantly through injecting drug use (IDU) [2, 3]. Despite the implementation of risk reduction strategies and treatment regimes, HCV transmission rates remain high amongst at risk populations and underscores the pressing need for alternative strategies such as an effective HCV vaccine. This thesis identified at risk populations within Australia that would benefit from an effective HCV vaccine. Subsequently, the immune responses elicited by HCV virus-like-particles (HCV VLPs) were evaluated in a murine model to assess their potential as an HCV vaccine candidate. Firstly, a review of HCV notifications for Victoria, Australia was undertaken utilising surveillance data from the Victorian Department of Health and population estimates from the Australian Bureau of Statistics. Total HCV notifications in Victoria between 2007 and 2011 have fallen from 2782 to 2370 cases (53.3 to 42.1 per 100,000 respectively). Interestingly HCV notifications rates in rural and metropolitan regions of Victoria were similar (46.97 and 44.05 per 100,000 respectively). In contrast HCV treatment rates in rural regions (7.4 - 7.9 per 100,000) were less than half that of metropolitan regions (17.6 - 18.5 per 100,000). Barriers and access to treatment particularly in rural areas need to be addressed as HCV treatment reduces transmission and secondary complications associated with chronic HCV infection. The review of HCV notifications also revealed IDU remains the greatest risk factor for HCV acquisition. Modelling suggests the introduction of an HCV vaccine, particularly in high risk groups such as seronegative IDUs, will have a substantial impact on the incidence of chronic HCV in the community [4-6]. Subsequently, a retrospective cohort study of 361 Australian travellers to Asia demonstrated travellers to endemic countries are also at risk of HCV infection and would benefit from a preventative vaccine. The incidence density of acute HCV infections in this cohort of travellers was 1.8 per 10,000 travel days. The study also identified the incidence density of HBV infection in non immune travellers was 2.19 per 10,000 travel days highlighting the need for both education and vaccination where available. Finally, the immune responses elicited by HCV virus-like-particles in a murine model were evaluated. HCV VLPs were designed in order to elicit the breadth of immune responses that are associated with spontaneous clearance of HCV. HCV VLPs were produced in Huh 7 cells (a human hepatoma cell line) and were shown to bind, enter and mature murine dendritic cells. BALB/c mice vaccinated with HCV VLPs demonstrated the…

Subjects/Keywords: hepatitis C

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APA (6^th Edition):

Johnson, D. F. (2013). An epidemiological to immunological basis for a hepatitis C vaccine. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/37881

Chicago Manual of Style (16^th Edition):

Johnson, Douglas Forsyth. “An epidemiological to immunological basis for a hepatitis C vaccine.” 2013. Doctoral Dissertation, University of Melbourne. Accessed March 01, 2021. http://hdl.handle.net/11343/37881.

MLA Handbook (7^th Edition):

Johnson, Douglas Forsyth. “An epidemiological to immunological basis for a hepatitis C vaccine.” 2013. Web. 01 Mar 2021.

Vancouver:

Johnson DF. An epidemiological to immunological basis for a hepatitis C vaccine. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/11343/37881.

Council of Science Editors:

Johnson DF. An epidemiological to immunological basis for a hepatitis C vaccine. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/37881

Ruhr Universität Bochum

15. Schrader, Stefanie. Die Rolle der Proteinkinase C für das Carbachol-induzierte Ca2+-Signal in primären β-Zellen der Maus.

Degree: 2009, Ruhr Universität Bochum

URL: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28029

► Die Regulation der Insulinfreisetzung in vivo ist ein komplexer Prozeß. Über unterschiedliche Mechanismen kommt es sowohl durch Aktivierung des PLC/IP3-als auch des c-AMP- Signaltransduktionsweges zu… (more)

Subjects/Keywords: Proteinkinase C; Calcium; Acetylcholin; Phospholipase C; Bauchspeicheldrüse

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APA (6^th Edition):

Schrader, S. (2009). Die Rolle der Proteinkinase C für das Carbachol-induzierte Ca2+-Signal in primären β-Zellen der Maus. (Thesis). Ruhr Universität Bochum. Retrieved from http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28029

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schrader, Stefanie. “Die Rolle der Proteinkinase C für das Carbachol-induzierte Ca2+-Signal in primären β-Zellen der Maus.” 2009. Thesis, Ruhr Universität Bochum. Accessed March 01, 2021. http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28029.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schrader, Stefanie. “Die Rolle der Proteinkinase C für das Carbachol-induzierte Ca2+-Signal in primären β-Zellen der Maus.” 2009. Web. 01 Mar 2021.

Vancouver:

Schrader S. Die Rolle der Proteinkinase C für das Carbachol-induzierte Ca2+-Signal in primären β-Zellen der Maus. [Internet] [Thesis]. Ruhr Universität Bochum; 2009. [cited 2021 Mar 01]. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28029.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schrader S. Die Rolle der Proteinkinase C für das Carbachol-induzierte Ca2+-Signal in primären β-Zellen der Maus. [Thesis]. Ruhr Universität Bochum; 2009. Available from: http://nbn-resolving.de/urn/resolver.pl?urn=urn:nbn:de:hbz:294-28029

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Federal de Mato Grosso do Sul

16. Tetila, Andyane Freitas. Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C .

Degree: 2011, Universidade Federal de Mato Grosso do Sul

URL: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/1847

► A infecção pelo vírus da hepatite C (HCV) não é rara em indivíduos infectados pelo vírus da imunodeficiência humana (HIV) e representa um importante problema… (more)

Subjects/Keywords: HIV; Coinfecção; Coinfection; Hepatite C; Hepatitis C

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APA (6^th Edition):

Tetila, A. F. (2011). Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C . (Thesis). Universidade Federal de Mato Grosso do Sul. Retrieved from http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/1847

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tetila, Andyane Freitas. “Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C .” 2011. Thesis, Universidade Federal de Mato Grosso do Sul. Accessed March 01, 2021. http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/1847.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tetila, Andyane Freitas. “Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C .” 2011. Web. 01 Mar 2021.

Vancouver:

Tetila AF. Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C . [Internet] [Thesis]. Universidade Federal de Mato Grosso do Sul; 2011. [cited 2021 Mar 01]. Available from: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/1847.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tetila AF. Características clínico-epidemiológicas e fatores associados à infecção pelo HIV em portadores da Hepatite Crônica C . [Thesis]. Universidade Federal de Mato Grosso do Sul; 2011. Available from: http://repositorio.cbc.ufms.br:8080/jspui/handle/123456789/1847

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vilnius Pedagogical University

17. Oleškevič, Marek. Programavimo kalbų naudojimo Lietuvos mokyklose analizė.

Degree: Master, Informatics, 2014, Vilnius Pedagogical University

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140723_101945-13824 ;

►

Šiame darbe yra apžvelgta programavimo kalbų istorija ir jų raida, pradedant nuo pačios pirmosios programos ir pirmosios programuotojos ir baigiant šiuolaikinėmis programavimo kalbomis. Taip pat… (more)

Subjects/Keywords: C++; Pascal; Raida; C++; Pascal; Evoliution

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APA (6^th Edition):

Oleškevič, Marek. (2014). Programavimo kalbų naudojimo Lietuvos mokyklose analizė. (Masters Thesis). Vilnius Pedagogical University. Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140723_101945-13824 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

Oleškevič, Marek. “Programavimo kalbų naudojimo Lietuvos mokyklose analizė.” 2014. Masters Thesis, Vilnius Pedagogical University. Accessed March 01, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140723_101945-13824 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

Oleškevič, Marek. “Programavimo kalbų naudojimo Lietuvos mokyklose analizė.” 2014. Web. 01 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Oleškevič, Marek. Programavimo kalbų naudojimo Lietuvos mokyklose analizė. [Internet] [Masters thesis]. Vilnius Pedagogical University; 2014. [cited 2021 Mar 01]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140723_101945-13824 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

Oleškevič, Marek. Programavimo kalbų naudojimo Lietuvos mokyklose analizė. [Masters Thesis]. Vilnius Pedagogical University; 2014. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140723_101945-13824 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Oregon State University

18. Kwon, Sun Hyung. Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts.

Degree: MS, Pharmacy, 2008, Oregon State University

URL: http://hdl.handle.net/1957/7449

► The mechanisms by which the activities of phospholipase C-β (PLC-β) enzymes are negatively regulated have not been well defined. We used cardiac-derived rat myoblast H9c2… (more)

Subjects/Keywords: Phospholipase C-beta; Phospholipase C – Physiological effect

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APA (6^th Edition):

Kwon, S. H. (2008). Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/7449

Chicago Manual of Style (16^th Edition):

Kwon, Sun Hyung. “Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts.” 2008. Masters Thesis, Oregon State University. Accessed March 01, 2021. http://hdl.handle.net/1957/7449.

MLA Handbook (7^th Edition):

Kwon, Sun Hyung. “Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts.” 2008. Web. 01 Mar 2021.

Vancouver:

Kwon SH. Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts. [Internet] [Masters thesis]. Oregon State University; 2008. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1957/7449.

Council of Science Editors:

Kwon SH. Properties of phospholipase C-β-mediated signaling in H9c2 cardiac myoblasts. [Masters Thesis]. Oregon State University; 2008. Available from: http://hdl.handle.net/1957/7449

University of Debrecen

19. Urbán, József. C-glikozilezési reakciók tanulmányozása .

Degree: DE – Természettudományi és Technológiai Kar – Kémiai Intézet, 2014, University of Debrecen

URL: http://hdl.handle.net/2437/191337

A 1-C szubsztituált glikálok palládium katalizált Heck-tipusú C-glikozilezési reakcióit végeztük. Elektron szívó csoportokat tartalmazó galaktál származékok C-glikozilezési reakcióit tanulmányoztuk. Advisors/Committee Members: Juhász, László (advisor).

Subjects/Keywords: C-glikozilezési reakció; 1-C szubsztituált glikál

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APA (6^th Edition):

Urbán, J. (2014). C-glikozilezési reakciók tanulmányozása . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/191337

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Urbán, József. “C-glikozilezési reakciók tanulmányozása .” 2014. Thesis, University of Debrecen. Accessed March 01, 2021. http://hdl.handle.net/2437/191337.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Urbán, József. “C-glikozilezési reakciók tanulmányozása .” 2014. Web. 01 Mar 2021.

Vancouver:

Urbán J. C-glikozilezési reakciók tanulmányozása . [Internet] [Thesis]. University of Debrecen; 2014. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2437/191337.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Urbán J. C-glikozilezési reakciók tanulmányozása . [Thesis]. University of Debrecen; 2014. Available from: http://hdl.handle.net/2437/191337

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

KTH

20. DEHBAREZ, AHMAD AMIRI. Utveckling av bokningssystem med .NET.

Degree: Information and Communication Technology (ICT), 2013, KTH

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128546

►

Examensarbetet har utförts åt det nystartade företaget Idop AB:s vägnar och har inneburit en vidareutveckling av ett befintligt webbaserad bokningssystem för det specifika företaget.… (more)

▼

Examensarbetet har utförts åt det nystartade företaget Idop AB:s vägnar och har inneburit en vidareutveckling av ett befintligt webbaserad bokningssystem för det specifika företaget. Huvudsyftet har varit att leverera en webbaserad bokningskalender där uthyrare kan lägga ut sina objekt samtidigt som intressenter kan boka dessa objekt. Dessa objekt kan omfattas av till exempel lägenheter, stugor och så vidare. Då projektet kräver att utvecklare och kund har ett nära samarbete valdes Skalning Agil metod som är en Agil metod, för att bäst uppnå detta syfte. Utvecklingen utav bokningssystemet skedde i en .NET miljö där programmeringsspråket var C#. För datalagring hade företaget Idop valt SQL server och interaktion med databasen sker genom Entity Framework. Resultatet av projektet blev en bokningskalender där uthyraren lägger ut sina lediga objekt för uthyrning under specifika datum samt uppger pris för den lediga perioden. Även intressenterna har nu möjlighet att preliminär boka ett specifikt objekt vid önskat datum. I rapporten förekommer mer detaljerad beskrivning av ovanståendenämnda punkter samt slutsatsen av projektet.

This project has been carried out on the recently started company Idop AB's behalf and has led to a further development of an existing webbased booking system for the mentioned company. The main goal has been to deliver a web-based booking calendar where advertiser can place their items while stakeholders can book these items. These items may be subject to such houses, cottages and so on. The project requires developers and customers to work closely, Scaling Agile Methods which is an agile method, was chosen for this purpose in order to best achieve this aim. The development of the booking system was written in a .NET environment in which the programming language was C#. For database, the company Idop AB had chosen SQL server and for interaction with the database Entity Framework. The outcome of the project was an online based booking calendar where the owners outsource their vacant properties for rent during specific dates and report the prices for the vacant period. The stakeholders are now able to make a preliminary booking of a specific object at the desired date. The report present more detailed description of the above mentioned points and the conclusion of the project.

Subjects/Keywords: .Net; C#; SQL; .Net; C#; SQL

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APA (6^th Edition):

DEHBAREZ, A. A. (2013). Utveckling av bokningssystem med .NET. (Thesis). KTH. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128546

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DEHBAREZ, AHMAD AMIRI. “Utveckling av bokningssystem med .NET.” 2013. Thesis, KTH. Accessed March 01, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128546.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DEHBAREZ, AHMAD AMIRI. “Utveckling av bokningssystem med .NET.” 2013. Web. 01 Mar 2021.

Vancouver:

DEHBAREZ AA. Utveckling av bokningssystem med .NET. [Internet] [Thesis]. KTH; 2013. [cited 2021 Mar 01]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128546.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DEHBAREZ AA. Utveckling av bokningssystem med .NET. [Thesis]. KTH; 2013. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-128546

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rice University

21. Majeti, Deepak. Portable Programming Models for Heterogeneous Platforms.

Degree: PhD, Engineering, 2015, Rice University

URL: http://hdl.handle.net/1911/88096

► With the end of Dennard scaling and emergence of dark silicon, the bets are high on heterogeneous architectures to achieve both application performance and energy… (more)

▼ With the end of Dennard scaling and emergence of dark silicon, the bets are high on heterogeneous architectures to achieve both application performance and energy efficiency. However, diversity in heterogeneous architectures poses severe programming challenges in terms of data layout, memory coherence, task partitioning, data distribution, and sharing of virtual addresses. Existing high-level programming languages are inadequate to address these new architectural features since they lack the necessary abstractions to address the challenges mentioned above. It is necessary for existing languages to be extended minimally with high-level constructs while maintaining existing standards of portability, performance, and productivity. The compiler and runtime together must efficiently map these constructs to a target architecture. We develop Concord, a C++ based programming model that extends the Intel Threading Building Blocks onto integrated heterogeneous CPU+GPU architectures that do not share the same virtual address between CPU and GPU. Concord supports many C++ features including virtual functions. We implement Shared Virtual Memory to map applications with pointer intensive data structures onto heterogeneous architectures that do not share the same virtual address. We introduce Heterogeneous Habanero-C (H2C), an implementation of the Habanero execution model targeting modern heterogeneous architectures with multiple devices. H2C provides high-level constructs to specify the computation, communication and synchronization in a given application. The H2C compiler and runtime frameworks efficiently map these high-level constructs onto the underlying heterogeneous hardware. The highlights of H2C include: a data layout framework to generate code with best data layout suited for a given memory hierarchy; constructs to specify a task partition, leaving the complex analysis of determining the resultant data distribution to the compiler; and a unified event framework that allows a programmer to write applications with a macro data-flow model onto heterogeneous architectures. Experimental results show Concord and H2C provide good portability, productivity, and performance. In the future, we believe heterogeneous architectures will be more diverse and more pervasive. We believe programming systems like H2C and Concord that have a tight integration of language, compiler and runtime are the right way to target current and future heterogeneous systems. Advisors/Committee Members: Sarkar, Vivek (advisor), Mellor-Crummey, John (committee member), Warburton, Timothy C (committee member), Barik, Rajkishore (committee member).

Subjects/Keywords: programming models; heterogeneous architectures; OpenCL; C++; C

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Majeti, D. (2015). Portable Programming Models for Heterogeneous Platforms. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/88096

Chicago Manual of Style (16^th Edition):

Majeti, Deepak. “Portable Programming Models for Heterogeneous Platforms.” 2015. Doctoral Dissertation, Rice University. Accessed March 01, 2021. http://hdl.handle.net/1911/88096.

MLA Handbook (7^th Edition):

Majeti, Deepak. “Portable Programming Models for Heterogeneous Platforms.” 2015. Web. 01 Mar 2021.

Vancouver:

Majeti D. Portable Programming Models for Heterogeneous Platforms. [Internet] [Doctoral dissertation]. Rice University; 2015. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1911/88096.

Council of Science Editors:

Majeti D. Portable Programming Models for Heterogeneous Platforms. [Doctoral Dissertation]. Rice University; 2015. Available from: http://hdl.handle.net/1911/88096

University of Illinois – Urbana-Champaign

22. Osberger, Thomas Joseph. Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs.

Degree: PhD, Chemistry, 2016, University of Illinois – Urbana-Champaign

URL: http://hdl.handle.net/2142/92900

► Hydroxyamino acid motifs are well-represented structures in natural products and pharmaceuticals, and are widely employed as synthetic building blocks in organic synthesis. In nature, such… (more)

▼ Hydroxyamino acid motifs are well-represented structures in natural products and pharmaceuticals, and are widely employed as synthetic building blocks in organic synthesis. In nature, such compounds are often synthesized via enzymatic C-H oxidation of simple amino acid precursors. Inspired by such processes, small molecule catalysts have been developed to perform a variety of C-H oxidation reactions, which have increased the efficiency of synthetic routes and allowed for late-stage diversification of complex molecules. This work describes the development and application of two transition metal catalyzed C-H oxidation reactions for the synthesis and diversification of hydroxyamino acids and related molecules. α-Hydroxy-β-amino acids are an important subclass of the hydroxyamino acid family, examples of which are found in pharmaceutical agents including taxol and bestatin. Current synthetic methods for the construction of these molecules often rely on the use of pre-oxidized fragments or harsh reagents. This work reports the merging of Brønsted acid catalysis with Pd(II)/bis-sulfoxide catalyzed allylic C-H oxidation to achieve the synthesis of vinyl-oxazolidinones from simple homoallylic, N-Boc protected amines. It is shown that utilization of dibutylphosphate as a co-catalyst with a Pd(II)/bis-sulfoxide catalyst produces optimal reactivity, affording anti¬-vinyl-oxazolidinones. These products are versatile synthetic intermediates, and their synthetic derivatization into α-hydroxy-β-amino acids as well as intermediates to amino sugars is demonstrated. Furthermore, the high functional group tolerance of the reaction enabled late-stage cyclization on a leucine-β-allylglycine dipeptide substrate to install a vinyl oxazolidinone moiety. Mechanistic investigations into the role of the dibutylphosphate co-catalyst revealed that it may play multiple roles beyond promoting formation of a cationic π-allylPd intermediate, including serving as an anionic ligand to palladium capable of performing allylic C-H cleavage. Natural products of nonribosomal peptide synthetase (NRPS) origin posses complex topologies and diverse functional group arrays that lead to varied and impressive therapeutic potential. The structural diversity achieved among these natural products is due in large part to a biosynthetic strategy that employs pre- and post-assembly oxidative modifications of individual amino acid building blocks and fully assembled peptide chains, exemplified in the biosynthesis of vancomycin. In many cases, diversification is achieved via enzymatic hydroxylation of amino acids to form unnatural amino acids that are incorporated into a larger peptide structure, or are intermediates for further diversification of an amino acid. Here we report a strategy inspired by the elegant approach of NRPS biosynthetic systems, wherein small molecule iron catalysts Fe(PDP) and Fe(CF3PDP) enable the oxidative diversification of amino acids and peptides. In particular, a highly chemoselective hydroxylation at C5 of proline residues produces… Advisors/Committee Members: White, M. Christina (advisor), White, M. Christina (Committee Chair), Denmark, Scott E (committee member), Katzenellenbogen, John A (committee member), van der Donk, WIlfred A (committee member).

Subjects/Keywords: C-H Functionalization; C-H Oxidation; Catalysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Osberger, T. J. (2016). Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs. (Doctoral Dissertation). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/92900

Chicago Manual of Style (16^th Edition):

Osberger, Thomas Joseph. “Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs.” 2016. Doctoral Dissertation, University of Illinois – Urbana-Champaign. Accessed March 01, 2021. http://hdl.handle.net/2142/92900.

MLA Handbook (7^th Edition):

Osberger, Thomas Joseph. “Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs.” 2016. Web. 01 Mar 2021.

Vancouver:

Osberger TJ. Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs. [Internet] [Doctoral dissertation]. University of Illinois – Urbana-Champaign; 2016. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2142/92900.

Council of Science Editors:

Osberger TJ. Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs. [Doctoral Dissertation]. University of Illinois – Urbana-Champaign; 2016. Available from: http://hdl.handle.net/2142/92900

23. Berges, Julien. Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free.

Degree: Docteur es, Ingénierie Moléculaire, 2016, Montpellier, Ecole nationale supérieure de chimie

URL: http://www.theses.fr/2016ENCM0014

►

Le sujet de cette thèse se situe dans le cadre général des arylations de nucléophiles catalysées par des complexes de métaux de transitions (Cu, Fe)… (more)

▼

Le sujet de cette thèse se situe dans le cadre général des arylations de nucléophiles catalysées par des complexes de métaux de transitions (Cu, Fe) ou réalisées en absence de ces derniers, dans des conditions compétitives et respectueuses de l’environnement. Ces réactions sont d’une importance majeure pour l’industrie chimique. Dans un premier chapitre est tout d’abord décrit un couplage inédit mettant en jeu un sel d’aryldiazonium et un nucléophile azoté (formation de liaison CAr-N). La méthode procède dans des conditions douces via un système catalytique au cuivre peu coûteux et peu toxique. Les produits de couplage obtenus (Ar-NHet) sont d’un intérêt central dans l’industrie pharmaceutique et agrochimique. Dans une deuxième partie nous avons présenté une méthode permettant de réaliser le couplage entre des sels d’aryldiazonium et des dérivés du styrène, à l’aide d’un système t BuOK/DMF. Cette réaction, réalisée pour la première fois en absence de catalyseurs à base de métaux de transition, permet d’accéder, via la formation de liaisons CArsp²-Csp², à des motifs stilbènes variés qui trouvent de nombreuses applications en chimie pharmaceutique. Un deuxième chapitre porte sur l’utilisation de dérivés de l’iode hypervalent permettant la fonctionnalisation de noyaux aromatiques (C-H) ou de dérivés vinyliques (C-H). Une première méthode décrit une réaction de triflimidation directe de composés acétanilides avec une sélectivité exclusive en position para. Deux conditions réactionnelles ont été mises en place pour cette fonctionnalisation. Une première utilise une quantité stœchiométrique de PhI(OAc)2 et une autre utilise une quantité catalytique d’iodotoluène (génération in-situ de l’iode(III)). Cette transformation a conduit à la formation de liaisons CAr-N en présence de bis(trifluorométhane)sulfonimide de lithium (LINTf2) comme nucléophile azoté. Dans une deuxième partie, nous avons montré que l’iodure de bisphosphoranilidène (PNPI), pouvait catalyser la trifluorométhylation vinylique sélective de dérivés du styrène en présence d’un réactif de l’iode hypervalent (l’iode(III)), le réactif de Togni II. Des travaux sont en cours pour tenter de comprendre l’influence positive de l’utilisation de PNPI dans le cas de notre réaction. Un troisième chapitre décrit des résultats préliminaires permettant d’obtenir un rendement honorable (54%) lors du couplage catalysé au fer du 4-iodotoluène avec le phényllithium. Une autre série de test décrit le couplage entre des halogénures d’aryle et des alkyllithium primaires. La méthode semble très efficace, puisque par ailleurs les travaux très récents de la littérature pour des couplages similaires faisant intervenir les mêmes partenaires réactionnels, font appel à des catalyseurs de fer ou de palladium.

This thesis is part of a very general search seek to develop methodologies for environmentally sustainable conversion of small molecules into more valuable substances catalyzed by copper and iron complexes or under metal-free conditions. The work focuses on the functionalization of…

Advisors/Committee Members: Taillefer, Marc (thesis director).

Subjects/Keywords: Catalyse; Fer; Noyaux aromatiques; Cuivre; Liaisons C-N; C-O et C-C; Catalysis; Iron; Aromatics Rings; Copper; C-N; C-O and C-C bonds; 540

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Berges, J. (2016). Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free. (Doctoral Dissertation). Montpellier, Ecole nationale supérieure de chimie. Retrieved from http://www.theses.fr/2016ENCM0014

Chicago Manual of Style (16^th Edition):

Berges, Julien. “Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free.” 2016. Doctoral Dissertation, Montpellier, Ecole nationale supérieure de chimie. Accessed March 01, 2021. http://www.theses.fr/2016ENCM0014.

MLA Handbook (7^th Edition):

Berges, Julien. “Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free.” 2016. Web. 01 Mar 2021.

Vancouver:

Berges J. Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free. [Internet] [Doctoral dissertation]. Montpellier, Ecole nationale supérieure de chimie; 2016. [cited 2021 Mar 01]. Available from: http://www.theses.fr/2016ENCM0014.

Council of Science Editors:

Berges J. Formation de liaisons C-C et C-N par catalyse au Cuivre, au Fer ou en absence de metal de transition : Formation of C-C and C-N bonds catalyzed by Copper, Iron or transition metal-free. [Doctoral Dissertation]. Montpellier, Ecole nationale supérieure de chimie; 2016. Available from: http://www.theses.fr/2016ENCM0014

24. Calland, Noémie. L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry.

Degree: Docteur es, Biochimie et biologie moléculaire, 2012, Université Lille II – Droit et Santé

URL: http://www.theses.fr/2012LIL2S031

► L’hépatite C est un problème majeur de santé publique qui touche environ 160 millions de personnes dans le monde. L’agent étiologique responsable de cette maladie,… (more)

▼ L’hépatite C est un problème majeur de santé publique qui touche environ 160 millions de personnes dans le monde. L’agent étiologique responsable de cette maladie, le virus de l’hépatite C (HCV), est un petit virus enveloppé dont le génome est codé par un acide ribonucléique (ARN) simple brin de polarité positive. Actuellement, il n’existe aucun vaccin contre ce pathogène et les traitements utilisés sont insatisfaisants du fait de leur spécificité d’action limitée. Ainsi, afin d’établir une thérapie antivirale efficace évitant l’apparition et la sélection de mutants de résistance aux antiviraux, l’utilisation de plusieurs agents antiviraux ciblant directement la particule virale (direct acting antiviral agents ou DAAs) en combinaison est préconisée. C’est pourquoi la découverte de nouveaux DAAs à large spectre d’action ciblant diverses étapes du cycle viral infectieux est indispensable.Au cours de ma thèse, nous avons identifié un nouvel inhibiteur de l’entrée du HCV : l’épigallocatéchine-3-gallate (EGCG). Cette molécule, extraite du thé vert, inhibe l’infection des cellules par le HCV. Plus précisément, en utilisant des particules rétrovirales pseudotypées avec les glycoprotéines d’enveloppe E1 et E2 du HCV, nous avons démontré que cette catéchine naturelle, agit à une étape très précoce de l’entrée virale, indépendamment du génotype. De même, en nous servant du virus produit en culture cellulaire, nous avons montré que cette molécule agit directement sur la particule virale. Puis, par RT-PCR quantitative (quantitative real-time polymerase chain reaction), nous avons confirmé l’inhibition de la liaison du virus à la surface cellulaire, en présence d’EGCG. Par conséquent, nos travaux suggèrent que l’EGCG interagit avec la particule virale, probablement en se liant aux glycoprotéines d’enveloppe virales, bloquant ainsi une étape initiale d’attachement entre le virus et les facteurs cellulaires présents à la surface de l’hépatocyte. Puis, en inhibant la transmission libre du virus, à l’aide, soit d’agarose, soit d’anticorps neutralisants, nous avons démontré que l’EGCG inhibe la transmission du virus de cellule à cellule. Enfin, nous avons montré que l’EGCG élimine le virus présent dans le surnageant de culture cellulaire après quatre passages successifs sur des cellules naïves.La concentration d’EGCG nécessaire pour inhiber la moitié de l’infection virale (IC50) en culture cellulaire est 11 µM. Ainsi, afin d’identifier de nouvelles molécules présentant un mode d’action similaire à celui de l’EGCG et possédant une meilleure activité antivirale, nous avons sélectionnés différentes molécules naturelles et les avons testés pour leur potentiel effet anti-HCV. C’est ainsi que le chlorure de delphinidine, une anthocyanidine, a également été identifié en tant que nouvelle molécule inhibitrice de l’entrée du HCV. De même que l’EGCG, le chlorure de delphinidine cible directement la particule virale à une étape précoce de l’entrée, indépendamment du génotype, probablement en inhibant l’attachement du virus à la surface… Advisors/Committee Members: Séron, Karin (thesis director).

Subjects/Keywords: EGCG; Delphinidine; Hépatite C; Hepatitis C virus

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Calland, N. (2012). L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry. (Doctoral Dissertation). Université Lille II – Droit et Santé. Retrieved from http://www.theses.fr/2012LIL2S031

Chicago Manual of Style (16^th Edition):

Calland, Noémie. “L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry.” 2012. Doctoral Dissertation, Université Lille II – Droit et Santé. Accessed March 01, 2021. http://www.theses.fr/2012LIL2S031.

MLA Handbook (7^th Edition):

Calland, Noémie. “L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry.” 2012. Web. 01 Mar 2021.

Vancouver:

Calland N. L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry. [Internet] [Doctoral dissertation]. Université Lille II – Droit et Santé 2012. [cited 2021 Mar 01]. Available from: http://www.theses.fr/2012LIL2S031.

Council of Science Editors:

Calland N. L'EGCG et la delphinidine : deux nouvelles molécules naturelles inhibant l'entrée du virus de l'hépatite C : EGCG and delphinidin : two new natural inhibitors of hepatitis C virus entry. [Doctoral Dissertation]. Université Lille II – Droit et Santé 2012. Available from: http://www.theses.fr/2012LIL2S031

25. Kotsiri, Ioanna. Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα.

Degree: 2016, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/37543

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Summary: TGF-β1 is an important pre-fibrinogenic cytokine, which is produced by the non-parenchymal liver cells, activates the hepatic asteroid cells and has been involved in… (more)

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Summary: TGF-β1 is an important pre-fibrinogenic cytokine, which is produced by the non-parenchymal liver cells, activates the hepatic asteroid cells and has been involved in the pathogenesis of liver fibrosis. For that reason, its role in the evolution of liver fibrosis has been studied for many years in patients with chronic hepatitis C (CHC) as well as with chronic hepatitis B. The purpose of this dissertation was to study the serum TGF-β1 levels, in association with liver fibrosis and to examine their change according to treatment response and their value as a predictive index in patients with CHC under antiviral treatment.Eighty four patients were included in the study (average age 46 years- old, 44 men, 40 women) with CHC belonging to all known HCV genotypes and were treated with pegylated interferon plus ribavirin. Liver fibrosis was estimated non-invasively with liver transient elastography. TGF-β1 levels were measured before and at the end of follow-up and 6 months after the completion of antiviral therapy using a standard immunoassay.TGF-β1 levels were not associated with epidemiological, biochemical or virological parameters. Univariate analysis showed association between antiviral treatment, age and white blood count, but not with the initial TGF-β1 levels. For patients with sustained virological response (SVR) TGF-β1 levels were significantly decreased at the end (12.327 pg/ml, p<0.0001) and 6 months after the completion of antiviral therapy (13.555 pg/ml, p=0.007) compared to baseline values (17.166 pg/ml), but not in patients showing relapse (11.487 vs 12.241 or 9.648 pg/ml, p=0.814 or p=0.344) or in patients showing non-response (16.319 vs 11.362 or 11.977 pg/ml, p=0.227 or p=0.695). There was no association between TGF-β1 and degree of liver fibrosis as estimated with transient elastography at baseline (p=0.29).In conclusion, our results shown that TGF-β1 displayed significant decrease in CHC patients with SVR to antiviral therapy. TGF-β1 levels are not associated with degree of liver fibrosis or to response to antiviral treatment.

ΠΕΡΙΛΗΨΗ: Ο TGF-β1 είναι μια σημαντική προ-ινωδογόνος κυτταροκίνη, παράγεται από τα μη παρεγχυματικά ηπατοκύτταρα, ενεργοποιεί τα ηπατικά αστεροειδή κύτταρα και έχει εμπλακεί στην παθογένεση της ηπατικής ίνωσης. Γι΄αυτό, ο ρόλος του στην εξέλιξη της ηπατικής ίνωσης έχει μελετηθεί για πολλά χρόνια, σε ασθενείς με χρόνια ηπατίτιδα C (CΗC) όσο και με χρόνια ηπατίτιδα B.Σκοπός της παρούσας διατριβής ήταν η μελέτη των επιπέδων του TGF-β1 στον ορό, η συσχέτισή τους με την ηπατική ίνωση, η μεταβολή τους ανάλογα με την ανταπόκριση στη θεραπεία, και η αξία του ως προγνωστικός δείκτης σε ασθενείς με χρόνια ηπατίτιδα C (CΗC) υπό αντιική θεραπεία.Στην μελέτη εντάχθηκαν 84 ασθενείς (μέση ηλικία 46 έτη, 44 άνδρες/40 γυναίκες) με ΧΗC όλων των γονοτύπων και τους χορηγήθηκε συνδυασμένη θεραπεία με πεγκυλιωμένη ιντερφερόνη και ριμπαβιρίνη. Η ηπατική ίνωση εκτιμήθηκε μη επεμβατικά με ελαστογραφία ήπατος. Τα επίπεδα του TGF-β1 στον ορό μετρήθηκαν πριν την έναρξη, στο τέλος και στους 6…

Subjects/Keywords: Χρόνια ηπατίτιδα C; Chronic hepatitis C

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kotsiri, I. (2016). Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/37543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kotsiri, Ioanna. “Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα.” 2016. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed March 01, 2021. http://hdl.handle.net/10442/hedi/37543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kotsiri, Ioanna. “Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα.” 2016. Web. 01 Mar 2021.

Vancouver:

Kotsiri I. Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10442/hedi/37543.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kotsiri I. Η σημασία του μετατρεπτικού αυξητικού παράγοντα β (tgf-β1) στη χρόνια ιογενή ηπατίτιδα. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2016. Available from: http://hdl.handle.net/10442/hedi/37543

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Polydoros, Konstantinides. Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D.

Degree: 2019, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/46058

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Several studies have provided conflicting results regarding the immune responses in chronic hepatitis C (CHC) patients with mixed cryoglobulinemia (MC). The importance of B-cell activating… (more)

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Several studies have provided conflicting results regarding the immune responses in chronic hepatitis C (CHC) patients with mixed cryoglobulinemia (MC). The importance of B-cell activating factor (BAFF) in MC has been described, but the role of interleukin (IL)-17A is less clear. Aim of the Study: The main objectives were to determine the levels of BAFF and IL-17A cytokines in patients with CHC with or without MC, and to investigate their kinetics during antiviral treatment with pegylated interferon-α/ribavirin and 6 months after the end of it. In addition, the aim was to evaluate the possible correlation of cytokines with vitD levels, the degree of hepatic fibrosis and the response to antiviral therapy. Furthermore, the results were correlated with demographic and laboratory data of the patients under study.Methods: Serum concentrations of IL-17A, BAFF and 25-OH vitamin D were measured in 34 CHC patients at baseline, end of treatment, and 6 months post-treatment with pegylated interferon-α and ribavirin, versus 12 healthy controls.Results: Thirty-four patients (20 male, mean age 40.7±9.2 years, 12 of genotype 1 or 4, 22 of genotype 2 or 3) were included, of whom 64.7% achieved a sustained virological response (SVR). MC was detected in 52.9% of the patients. Higher levels of both cytokines were found in patients with MC compared to those without. Patients who achieved SVR had higher pretreatment IL-17A and lower BAFF levels compared to those without SVR. IL-17A was downregulated during and following treatment in responders, whereas upregulation was observed in non-responders. CHC patients demonstrated low vitamin D levels compared to HC. Moreover, the changes in IL-17A over the treatment period were significantly associated with vitamin D changes (β=-0.04, SE=0.02, P=0.046). No difference in IL-17A, BAFF and vitamin D values was seen between patients with cirrhosis (n=14) and those without.Conclusions: CHC patients with asymptomatic MC have increased levels of IL-17A and BAFF. IL-17A levels decline significantly while BAFF increases during treatment in responders. An interplay between IL-17A and vitamin D concentrations was revealed during the antiviral treatment.Keywords: Interleukin 17A, B-cell activating factor, vitamin D, chronic hepatitis C, mixed cryoglobulinemia

Αρκετές μελέτες παρουσίασαν αντικρουόμενα αποτελέσματα σχετικά με τις ανοσολογικές αντιδράσεις σε ασθενείς με χρόνια ηπατίτιδα C (CHC) και μικτή κρυοσφαιριναιμία (MC). Η σημασία του ενεργοποιητικού παράγοντα των Β λεμφοκυττάρων (BAFF) στη MC έχει περιγραφεί προηγουμένως, αλλά ο ρόλος της ιντερλευκίνης (IL)-17A είναι λιγότερο σαφής. Σκοπός: Οι κύριοι στόχοι της παρούσας μελέτης ήταν ο προσδιορισμός των επιπέδων των κυτταροκινών BAFF και IL-17A σε ασθενείς που πάσχουν από CHC με ή χωρίς MC, και η διερεύνηση της κινητικής τους κατά τη διάρκεια της αντιιικής θεραπείας με pegIFN/RBV και 6 μήνες μετά το τέλος αυτής. Επιπρόσθετα, θέλαμε να αξιολογήσουμε τη σχέση των κυτταροκινών με τα επίπεδα της vitD, το βαθμό της ηπατικής ίνωσης και την ανταπόκριση στην…

Subjects/Keywords: Χρόνια ηπατίτιδα C; Chronic hepatitis C

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Polydoros, K. (2019). Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/46058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Polydoros, Konstantinides. “Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D.” 2019. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed March 01, 2021. http://hdl.handle.net/10442/hedi/46058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Polydoros, Konstantinides. “Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D.” 2019. Web. 01 Mar 2021.

Vancouver:

Polydoros K. Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2019. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10442/hedi/46058.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Polydoros K. Η ιντερλευκίνη-17Α και ο ενεργοποιητικός παράγοντας των Β λεμφοκυττάρων σε ασθενείς με χρόνια ηπατίτιδα C και μικτή κρυοσφαιριναιμία: επιδράσεις της αντιιικής θεραπείας και συσχετίσεις με τη βιταμίνη D. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2019. Available from: http://hdl.handle.net/10442/hedi/46058

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Karamichali, Eirini. Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C.

Degree: 2014, University of Patras; Πανεπιστήμιο Πατρών

URL: http://hdl.handle.net/10442/hedi/35595

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HCV infection is a major public health problem and a leading cause of chronic liver disease and hepatocellular carcinoma, with approximately 180 million infected individuals… (more)

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HCV infection is a major public health problem and a leading cause of chronic liver disease and hepatocellular carcinoma, with approximately 180 million infected individuals worldwide. HCV is a positive sense RNA virus that belongs to the genus hepacivirus of the Flaviviridae family. Six major HCV genotypes (1–6) are known, each of which can be further subdivided into several subtypes (1a, 1b, 2a, etc). The HCV genome consists of a large open reading frame (ORF), flanked by highly structured 5’ and 3’ untranslated regions (UTRs). Both UTRs are conserved and control viral translation and replication. The HCV 5'-UTR contains an IRES that initiates cap-independent translation of the viral RNA. IRES-mediated translation of the HCV ORF yields a single polyprotein precursor that is co- and post-translationally processed by cellular and viral proteases, giving rise to mature structural and non structural proteins. Several studies have suggested that different cellular non canonical proteins or viral proteins can regulate the HCV IRES activity. The aim of this study was to understand the regulation of the HCV IRES dependent translation. Firstly, we tried to delineate the role of the viral proteins on HCV IRES dependent translation that still remains controversial. Clearly our studies demonstrated that HCV NS5A down-regulates IRES activity in a cell-type dependent manner. Additionally, we provide strong evidence that activated PKR up-regulates the IRES activity while silencing of endogenous PKR had the opposite effect. In addition, we concluded that the NS5A-mediated inhibitory effect on IRES-dependent translation was linked with the PKR inactivation. Moreover, as it is already reported that localised hypoxic areas are continuously present in HCC due to its high proliferation rate leading to an altered translation pattern, we investigated modulation of HCV IRES activity under low oxygen settings. Our results provided preliminary evidence that HCV-IRES-dependent translation is negatively regulated by low oxygen levels or under hypoxia-mimicking conditions in cell-specific manner.

H λοίμωξη που προκαλείται απο τον ιό της ηπατίτιδας C HCV είναι μείζον πρόβλημα για την δημόσια υγεία όπως επίσης και η κύρια αιτία της χρόνιας ηπατικής νόσου και ηπατοκυτταρικού καρκινώματος, με περίπου 180 εκατομμύρια μολυσμένα άτομα σε όλο τον κόσμο. Ο HCV είναι ένας RNA ιός θετικής πολικότητας που ανήκει στο γένος Hepacivirus της οικογένειας των Flaviviridae. Έξι γονότυποι ( 1-6 ) είναι γνωστοί, καθένας από τους οποίους μπορεί να υποδιαιρεθεί περαιτέρω σε αρκετές υποτύπους. Το γονιδίωμα του HCV αποτελείται από ένα μεγάλο ανοικτό πλαίσιο ανάγνωσης (ORF), πλαισιωμένο από ιδιαίτερα δομημένες 5 'και 3' αμετάφραστες περιοχές (UTRs). Και οι δύο περιοχές UTRs είναι συντηρημένες και έχουν τον έλεγχο της ιογενούς μετάφρασης και αναπαραγωγής. Το 5' UTR του HCV περιέχει μια περιοχή IRES απο την οποία γινεται η έναρξη της cap ανεξάρτητης μετάφρασης του ιικού RNA. Η HCV IRES εξαρτώμενη μετάφραση του ORF παράγει μια ενιαία πρόδρομη…

Subjects/Keywords: Ηπατίτιδα C, Ιός (HCV); Hepatitis C

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Karamichali, E. (2014). Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C. (Thesis). University of Patras; Πανεπιστήμιο Πατρών. Retrieved from http://hdl.handle.net/10442/hedi/35595

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Karamichali, Eirini. “Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C.” 2014. Thesis, University of Patras; Πανεπιστήμιο Πατρών. Accessed March 01, 2021. http://hdl.handle.net/10442/hedi/35595.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Karamichali, Eirini. “Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C.” 2014. Web. 01 Mar 2021.

Vancouver:

Karamichali E. Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C. [Internet] [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2014. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10442/hedi/35595.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Karamichali E. Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C. [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2014. Available from: http://hdl.handle.net/10442/hedi/35595

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Mamede, Ana Catarina Manjolinha. Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos.

Degree: 2010, RCAAP

URL: http://www.rcaap.pt/detail.jsp?id=oai:ubibliorum.ubi.pt:10400.6/2296

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A vitamina C é um nutriente essencial ao metabolismo das células vivas que existe sob duas formas: a forma reduzida (ácido ascórbico - AA) e… (more)

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A vitamina C é um nutriente essencial ao metabolismo das células vivas que existe sob duas formas: a forma reduzida (ácido ascórbico - AA) e a forma oxidada (ácido dehidroascórbico – DHA). A vitamina C é um nutriente cujos benefícios são desde há muito tempo conhecidos e amplamente divulgados, sendo que a sua maioria se devem à acção antioxidante desta vitamina. Como antioxidante, o principal papel da vitamina C é neutralizar os radicais livres doando-lhes os seus electrões, reflectindo a sua capacidade redutora e a habilidade para diminuir o stresse oxidativo. No entanto, alguns estudos controversos sugerem que este nutriente possa ter um papel preventivo e terapêutico na doença oncológica devido à sua eventual actividade pró-oxidante, promovendo a formação de espécies reactivas de oxigénio que podem induzir a morte celular nas células cancerígenas. Este factor, aliado à diminuição das enzimas antioxidantes e ao aumento de metais de transição descompartimentalizados nas células tumorais poderá resultar na citotoxicidade selectiva da vitamina C e na consequente revelação do seu potencial terapêutico. O objectivo deste trabalho é estudar o metabolismo e os mecanismos de acção da forma reduzida da vitamina C e mostrar o seu efeito citotóxico em duas linhas celulares tumorais: adenocarcinoma colorectal (WiDr) e melanoma melanocítico (A-375). Para tal, usaram-se técnicas de imagiologia nuclear e de biologia celular e molecular. Primeiramente, efectuou-se a marcação da forma reduzida da vitamina C com tecnécio-99m, de forma a obter um complexo radioactivo (99mTc-AA) passível de ser usado em imagiologia nuclear. Posteriormente, nos estudos in vitro, procedeu-se à realização de estudos de captação de 99mTc-AA e de pertecnetato de sódio nas duas linhas celulares estudadas, assim como à avaliação da citotoxicidade da vitamina através da avaliação da proliferação celular por espectrofotometria, ensaios clonogénicos e citometria de fluxo. Foram também feitos estudos in vivo com ratinhos Balb/c e Balb/c nu/nu com o intuito de comprovar os resultados obtidos no controlo de qualidade do 99mTc-AA e obter informação sobre a biodistribuição e vias de excreção e metabolização da formulação produzida. Por último, os ratinhos com xenotransplantes foram submetidos a uma terapia com AA e os tumores excisados foram analisados por citometria de fluxo. Os resultados obtidos sugerem que a forma reduzida da vitamina C induz um efeito anti-proliferativo e/ou citotóxico nas células em estudo, podendo eventualmente vir a constituir uma nova abordagem terapêutica no tratamento do cancro colorectal.

min C is an essential nutrient to the metabolism of living cells which exist in two forms: the reduced form (ascorbic acid - AA) and oxidized form (dehydroascorbic acid - DHA). Vitamin C is a nutrient whose benefits are long known and widely publicized, being most of them related to the antioxidant action of this vitamin. As an antioxidant, the main role of vitamin C is neutralize free radicals by donating their electrons to them, reflecting their…

Advisors/Committee Members: Botelho, Maria Filomena Rabaça Roque, Pereira, Jorge Manuel Maia, Abrantes, Ana Margarida Coelho.

Subjects/Keywords: Vitamina C; Vitamina C - Cancro; Ácido ascórbico; Vitamina C - Citotoxicidade; Vitamina C - Biodistribuição

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mamede, A. C. M. (2010). Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos. (Thesis). RCAAP. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:ubibliorum.ubi.pt:10400.6/2296

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mamede, Ana Catarina Manjolinha. “Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos.” 2010. Thesis, RCAAP. Accessed March 01, 2021. http://www.rcaap.pt/detail.jsp?id=oai:ubibliorum.ubi.pt:10400.6/2296.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mamede, Ana Catarina Manjolinha. “Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos.” 2010. Web. 01 Mar 2021.

Vancouver:

Mamede ACM. Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos. [Internet] [Thesis]. RCAAP; 2010. [cited 2021 Mar 01]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:ubibliorum.ubi.pt:10400.6/2296.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mamede ACM. Vitamina C, cancro e citotoxicidade selectiva: estudos biológicos. [Thesis]. RCAAP; 2010. Available from: http://www.rcaap.pt/detail.jsp?id=oai:ubibliorum.ubi.pt:10400.6/2296

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

29. Garrone, Nicholas Felix. Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain.

Degree: PhD, Human Genetics, 2010, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1258/rec/518

► A defining feature of NEDD4L protein isoforms is the presence or absence of an amino-terminal C2 domain, a class of subcellular, calcium-dependent targeting domains. We… (more)

Subjects/Keywords: Protein Kinase C

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garrone, N. F. (2010). Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1258/rec/518

Chicago Manual of Style (16^th Edition):

Garrone, Nicholas Felix. “Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain.” 2010. Doctoral Dissertation, University of Utah. Accessed March 01, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1258/rec/518.

MLA Handbook (7^th Edition):

Garrone, Nicholas Felix. “Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain.” 2010. Web. 01 Mar 2021.

Vancouver:

Garrone NF. Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain. [Internet] [Doctoral dissertation]. University of Utah; 2010. [cited 2021 Mar 01]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1258/rec/518.

Council of Science Editors:

Garrone NF. Functional Analysis of Neural Precursor Cell Expressed Developmentally Down Regulated, Gene 4 Isoforms that Contain or Lack a Conserved Region 2 of Protein Kinase C Domain. [Doctoral Dissertation]. University of Utah; 2010. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/1258/rec/518

San Jose State University

30. Varshney, Aruna. Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition.

Degree: MS, Biological Sciences, 2012, San Jose State University

URL: https://doi.org/10.31979/etd.k8yd-csn3 ; https://scholarworks.sjsu.edu/etd_theses/4218

► Sensation and cognition are some of the fundamental human experiences. Our work aimed to understand the molecules responsible for the formation of proper neural… (more)

Subjects/Keywords: C. elegans; Synaptogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Varshney, A. (2012). Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition. (Masters Thesis). San Jose State University. Retrieved from https://doi.org/10.31979/etd.k8yd-csn3 ; https://scholarworks.sjsu.edu/etd_theses/4218

Chicago Manual of Style (16^th Edition):

Varshney, Aruna. “Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition.” 2012. Masters Thesis, San Jose State University. Accessed March 01, 2021. https://doi.org/10.31979/etd.k8yd-csn3 ; https://scholarworks.sjsu.edu/etd_theses/4218.

MLA Handbook (7^th Edition):

Varshney, Aruna. “Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition.” 2012. Web. 01 Mar 2021.

Vancouver:

Varshney A. Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition. [Internet] [Masters thesis]. San Jose State University; 2012. [cited 2021 Mar 01]. Available from: https://doi.org/10.31979/etd.k8yd-csn3 ; https://scholarworks.sjsu.edu/etd_theses/4218.

Council of Science Editors:

Varshney A. Elucidation of the Molecular Pathway That Mediates Synaptic Partner Recognition. [Masters Thesis]. San Jose State University; 2012. Available from: https://doi.org/10.31979/etd.k8yd-csn3 ; https://scholarworks.sjsu.edu/etd_theses/4218

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