subject:(Bronchoconstriction)

1. Le Guen, Morgan. Effets de l'application d'un stretch cyclique sur un modèle isolé de bronche humaine : étude fonctionnelle, pharmacologique et immuno−génétique : Cyclic stretch applied on a model of human bronchic airway : functionnal, pharmacological and genetic response.

Degree: Docteur es, Physiologie, 2014, Versailles-St Quentin en Yvelines

URL: http://www.theses.fr/2014VERS0060

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L’arbre bronchique constitue une large interface avec le milieu extérieur ce qui en fait notamment une sentinelle immunologique. Par ailleurs, il est soumis à de… (more)

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L’arbre bronchique constitue une large interface avec le milieu extérieur ce qui en fait notamment une sentinelle immunologique. Par ailleurs, il est soumis à de multiples contraintes physiques (variation de pressions lors du cycle ventilatoire) avec le développement de pathologies lorsque la réponse à ces contraintes est inadaptée. Au cours de ce travail, nous avons essayé de caractériser la réponse bronchique des voies aériennes distales à partir d’un modèle isolé de bronche humaine soumis à l’application d’un stretch unique ou cyclique tel qu’il est généré lors de la ventilation mécanique. D’un point de vue fonctionnel, le stretch unique ou cyclique s’accompagne d’une modification significative du tonus basal de la bronche avec deux étapes : l’une précoce apparaît au cours de l’exposition même des variations de tension pariétale, l’autre est tardive et apparaît à l’arrêt de l’étirement. Concernant l’étape précoce, elle se révèle robuste car aucun pré-traitement et particulièrement l’abrasion de l’épithélium ne la supprime totalement. La caractérisation de cette réponse implique notamment la voie des NO synthases et des Rho-A kinase. La réponse tardive fait quant à elle intervenir l’épithélium ainsi que la voie des NO-synthase suggérant un rôle prépondérant du NO. Par contre, ces modifications de force au repos sont indépendantes de la sécrétion de médiateurs inflammatoires détectés par ELISA. L’approche génétique renforce par contre le rôle du tissu de soutien bronchique en activant la synthèse de collagène (MMP-9). Au total l'application d'une contrainte cyclique renforce la bronchoconstriction par inhibition de la voie des NOsynthases et de la mécanotransduction.

The tracheo-bronchial tree is a true immunologic sentinel related to the huge interface with the external environment. Moreover, it is submitted to variable physical strains (tidal ventilation and variation in pressure) and an excessive response leads to the genesis of some pathology as hyperresponsiveness. The aim of this work on an isolated organ model was to characterize the human bronchial response to a single or repetitive and physiological stretch as observed during mechanical ventilation. From a functional perspective, a single strain or a cyclic stretch significantly increased the basal tone of the human bronchus with a two-step response: the early response appears during cycling and the delayed after the stretch has ceased. The early response is robust then no pre-treatment and especially epithelial removal totally inhibits it. This response implies NO synthase and Rho-A kinase pathway with a reduction of the developed basal tone with these inhibitors. As it concerns the late response, it involved epithelium and NO synthase suggesting a prominent action of NO. Inflammatory mediators are not directly involved in the rise of basal tone because stretch-induced secretion as detected with ELISA is very low. Genomic approach transiently activates transcription of genes for MMP-9, involved in the collagen production and consequently in the support…

Advisors/Committee Members: Devillier, Philippe (thesis director).

Subjects/Keywords: Bronche humaine; Stretch cyclique; Bronchoconstriction; Ventilation; NO synthase; Cyclic stretch; Bronchoconstriction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Le Guen, M. (2014). Effets de l'application d'un stretch cyclique sur un modèle isolé de bronche humaine : étude fonctionnelle, pharmacologique et immuno−génétique : Cyclic stretch applied on a model of human bronchic airway : functionnal, pharmacological and genetic response. (Doctoral Dissertation). Versailles-St Quentin en Yvelines. Retrieved from http://www.theses.fr/2014VERS0060

Chicago Manual of Style (16^th Edition):

Le Guen, Morgan. “Effets de l'application d'un stretch cyclique sur un modèle isolé de bronche humaine : étude fonctionnelle, pharmacologique et immuno−génétique : Cyclic stretch applied on a model of human bronchic airway : functionnal, pharmacological and genetic response.” 2014. Doctoral Dissertation, Versailles-St Quentin en Yvelines. Accessed March 02, 2021. http://www.theses.fr/2014VERS0060.

MLA Handbook (7^th Edition):

Le Guen, Morgan. “Effets de l'application d'un stretch cyclique sur un modèle isolé de bronche humaine : étude fonctionnelle, pharmacologique et immuno−génétique : Cyclic stretch applied on a model of human bronchic airway : functionnal, pharmacological and genetic response.” 2014. Web. 02 Mar 2021.

Vancouver:

Le Guen M. Effets de l'application d'un stretch cyclique sur un modèle isolé de bronche humaine : étude fonctionnelle, pharmacologique et immuno−génétique : Cyclic stretch applied on a model of human bronchic airway : functionnal, pharmacological and genetic response. [Internet] [Doctoral dissertation]. Versailles-St Quentin en Yvelines; 2014. [cited 2021 Mar 02]. Available from: http://www.theses.fr/2014VERS0060.

Council of Science Editors:

Le Guen M. Effets de l'application d'un stretch cyclique sur un modèle isolé de bronche humaine : étude fonctionnelle, pharmacologique et immuno−génétique : Cyclic stretch applied on a model of human bronchic airway : functionnal, pharmacological and genetic response. [Doctoral Dissertation]. Versailles-St Quentin en Yvelines; 2014. Available from: http://www.theses.fr/2014VERS0060

2. Teixeira, Renata Nakata. Broncoespasmo induzido pelo exercício em corredores de longa distância.

Degree: Mestrado, Biodinâmica do Movimento Humano, 2008, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-16102008-102747/ ;

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A alta prevalência de broncoespasmo induzido pelo exercício (BIE) tem sido observada em atletas que praticam modalidades de longa duração. Até o presente momento, nenhum… (more)

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A alta prevalência de broncoespasmo induzido pelo exercício (BIE) tem sido observada em atletas que praticam modalidades de longa duração. Até o presente momento, nenhum estudo foi realizado no Brasil. Por essa razão, o objetivo deste estudo foi verificar a prevalência de BIE em corredores de longa distância. Para isto, 22 atletas do gênero masculino foram submetidos à prova de função pulmonar, teste de esforço ergoespirométrico e teste de broncoprovocação induzida por hiperpnéia (BIH). Os atletas responderam um questionário sobre sintomas de asma e forneceram informações relacionadas aos seus treinamentos. Após realizarem o teste de BIH, os atletas foram classificados de acordo com a variação do volume expiratório forçado no primeiro segundo (VEF1) em comparação ao valor basal. Aqueles que apresentaram queda do VEF1 igual ou superior a 10% foram denominados Grupo BIE+; os demais foram designados Grupo BIE-. Os resultados demonstraram a presença de BIE em 25% dos atletas. Não foram evidenciadas diferenças estatisticamente significantes em relação às características antropométricas, aos valores basais de função pulmonar, assim como aos parâmetros analisados durante o teste ergoespirométrico. Um aspecto interessante xi observado foi que, os atletas do Grupo BIE+ percorrem, nos seus treinamentos, uma distância inferior quando comparados aos atletas do Grupo BIE- (p≤0,05). Estes resultados sugerem que a presença de BIE pode limitar o rendimento esportivo

The high prevalence of exercise-induced bronchospasm (EIB) has been observed in endurance athletes. Until today, no such study had been conducted in Brazil. The aim of this study was to look for prevalence of EIB among long-distance runners. Twenty-two male athletes were subjected to pulmonary function tests, maximal exercise tests and hyperpnea-induced broncoprovocation (HIB). The athletes also answered questions about asthma symptoms and provided information about their training programs. After the HIB test, they were ranked by the variation in the FEV1 (Forced Expiratory Volume in the first second). Those with a decrease of 10% or more were labeled EIB+ group; all the others were labeled EIB - group. Results show the presence of exercise-induced bronchospasm in 25% of the athletes. Among them, there were no significant statistical differences related to anthropometric characteristics, basal pulmonary function values or other parameters analyzed during the ergospirometric test. One interesting aspect observed was that, in their training sessions, the EIB+ Group athletes ran a shorter distance when compared to those in the EIB- Group (p≤0.05). These results suggest that EIB presence may be a limitting factor in sports performance

Advisors/Committee Members: Teixeira, Luzimar Raimundo.

Subjects/Keywords: Asma; Asthma; Athletes; Atletas; Bronchoconstriction; Broncoconstrição

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Teixeira, R. N. (2008). Broncoespasmo induzido pelo exercício em corredores de longa distância. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/39/39132/tde-16102008-102747/ ;

Chicago Manual of Style (16^th Edition):

Teixeira, Renata Nakata. “Broncoespasmo induzido pelo exercício em corredores de longa distância.” 2008. Masters Thesis, University of São Paulo. Accessed March 02, 2021. http://www.teses.usp.br/teses/disponiveis/39/39132/tde-16102008-102747/ ;.

MLA Handbook (7^th Edition):

Teixeira, Renata Nakata. “Broncoespasmo induzido pelo exercício em corredores de longa distância.” 2008. Web. 02 Mar 2021.

Vancouver:

Teixeira RN. Broncoespasmo induzido pelo exercício em corredores de longa distância. [Internet] [Masters thesis]. University of São Paulo; 2008. [cited 2021 Mar 02]. Available from: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-16102008-102747/ ;.

Council of Science Editors:

Teixeira RN. Broncoespasmo induzido pelo exercício em corredores de longa distância. [Masters Thesis]. University of São Paulo; 2008. Available from: http://www.teses.usp.br/teses/disponiveis/39/39132/tde-16102008-102747/ ;

University of California – San Diego

3. Geier, Eric Thomas. Emergent patterns of bronchoconstriction: What can the healthy lung teach us about asthma?.

Degree: Biomedical Sciences, 2018, University of California – San Diego

URL: http://www.escholarship.org/uc/item/5d21x6vb

► Asthma is defined by its intermittence. Periods of normal function are interrupted by intermittent bouts of airflow obstruction, and the severity and frequency of these… (more)

▼ Asthma is defined by its intermittence. Periods of normal function are interrupted by intermittent bouts of airflow obstruction, and the severity and frequency of these bouts define the severity of the disease. Asthma also varies in space just as it does in time. Patches of the lung become compromised during an asthma attack, while the rest of the lung continues to function normally. This dissertation explores the intersection of these two modes of variation – what causes bronchoconstriction to occur in patches, and will it cause the same patches to emerge time after time? A seminal modeling study predicted that lung units under smooth muscle stress exhibit a type of emergent behavior; self-organized patches of constriction can arise from the small airways because of the interdependence of airflow through the airway tree. In a sense, airways “communicate” with each other through flow patterns in a way that allows large-scale patterns to emerge. One goal of this dissertation work was to empirically verify the findings of this model. We chose to perform studies in healthy normal subjects to ensure that the patterns of constriction we observed were due to interdependence and not to underlying inflammation or remodeling. The results of our first study (Chapter 2) found that bronchoconstriction – provoked with methacholine – in healthy subjects did indeed occur in a spatially patchy pattern. Further, we found that this patchy pattern was recurrent in challenges weeks to months apart. We showed that, although subjects each had a characteristic pattern of constriction, there was an overall tendency for the dependent lung to constrict when supine. Our second study (Chapter 3) showed that this was due to the interaction between gravitational compression of tissue and the underlying topography of the airway tree structure. Our final study (Chapter 4) showed that healthy subjects did not recover from constriction immediately after albuterol inhalation, even though traditional metrics of lung function indicated that they had. We interpreted this as evidence for the power and utility of functional imaging in detecting and characterizing pathologic function.

Subjects/Keywords: Physiology; Albuterol; Asthma; Bronchoconstriction; Functional Imaging; Methacholine; Specific Ventilation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Geier, E. T. (2018). Emergent patterns of bronchoconstriction: What can the healthy lung teach us about asthma?. (Thesis). University of California – San Diego. Retrieved from http://www.escholarship.org/uc/item/5d21x6vb

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Geier, Eric Thomas. “Emergent patterns of bronchoconstriction: What can the healthy lung teach us about asthma?.” 2018. Thesis, University of California – San Diego. Accessed March 02, 2021. http://www.escholarship.org/uc/item/5d21x6vb.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Geier, Eric Thomas. “Emergent patterns of bronchoconstriction: What can the healthy lung teach us about asthma?.” 2018. Web. 02 Mar 2021.

Vancouver:

Geier ET. Emergent patterns of bronchoconstriction: What can the healthy lung teach us about asthma?. [Internet] [Thesis]. University of California – San Diego; 2018. [cited 2021 Mar 02]. Available from: http://www.escholarship.org/uc/item/5d21x6vb.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Geier ET. Emergent patterns of bronchoconstriction: What can the healthy lung teach us about asthma?. [Thesis]. University of California – San Diego; 2018. Available from: http://www.escholarship.org/uc/item/5d21x6vb

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université du Québec à Montréal

4. Boudreau, Maxine. Réactivité bronchique aux tests de provocation respiratoire à la méthacholine et au dioxyde de carbone chez les patients asthmatiques avec et sans trouble panique.

Degree: 2016, Université du Québec à Montréal

URL: http://archipel.uqam.ca/8720/1/D3031.pdf

► La présente thèse doctorale a pour objectif d'évaluer la réactivité bronchique aux tests de provocation respiratoire à la méthacholine et au CO2 chez les patients… (more)

▼ La présente thèse doctorale a pour objectif d'évaluer la réactivité bronchique aux tests de provocation respiratoire à la méthacholine et au CO2 chez les patients souffrant d'asthme avec et sans TP. Dans un premier temps, elle permet d'évaluer l'influence d'une crise d'asthme simulée, grâce à l'inhalation de méthacholine, sur l'hyperréactivité bronchique, la détresse subjective, et l'activation physiologique chez les asthmatiques avec et sans TP. Dans un deuxième temps, cette thèse a aussi pour but l'évaluation de l'impact d'une attaque de panique simulée, grâce à l'inhalation de 35% de CO2, sur la bronchoconstriction, la détresse subjective, la variabilité respiratoire et l'activation physiologique chez les asthmatiques avec et sans TP. Afin de positionner la thèse doctorale dans son contexte, celle-ci est divisée en cinq chapitres. Le premier chapitre permet d'informer le lecteur des connaissances sur le TP et l'asthme issues des écrits scientifiques ayant permis l'élaboration des objectifs de recherche de la présente thèse. Le deuxième chapitre permet ensuite un bref retour sur les considérations méthodologiques afin contextualiser les articles scientifiques se retrouvant au sein du troisième et quatrième chapitre. Enfin, le cinquième chapitre contient une discussion générale concernant les principaux résultats de la thèse, les implications cliniques, la transmission des connaissances et les forces et faiblesses des études effectuées. Principalement, les résultats contenus dans le premier article indiquent que la présence d'un TP n'influencerait pas l'hyperréactivité bronchique, ni l'activation physiologique, chez les asthmatiques suite à une crise d'asthme simulée. Toutefois, les asthmatiques ayant un TP rapportaient significativement plus de détresse subjective suite au test de provocation respiratoire à la méthacholine en comparaison avec les asthmatiques n'ayant aucun trouble psychiatrique. Ces résultats suggèrent que la détresse subjective, possiblement déclenchée par la tendance à la catastrophisation des symptômes psychophysiologiques, pourrait expliquer la surutilisation des services de la santé, plutôt qu'en raison d'un asthme et des symptômes respiratoires objectivement plus sévères. De façon similaire, le deuxième article suggère qu'une attaque de panique provoquée par l'inhalation de 35% de CO2 n'aurait aucune influence sur la bronchoconstriction, donc sur le déclenchement d'une crise d'asthme, ni sur l'activation physiologique. Cependant, les asthmatiques ayant un TP et ayant vécu une attaque de panique suite à l'inhalation de CO2 ont fait l'expérience d'une détresse subjective et d'une variabilité respiratoire plus importante que ceux n'ayant pas fait d'attaque de panique. Ceci suggère qu'il est nécessaire de favoriser l'amélioration de la compréhension et du dépistage de la comorbidité TP-asthme par l'accès à des ressources spécialisées afin d'améliorer le pronostic, non seulement de la maladie mentale, mais aussi celui de la condition médicale. Ainsi, un traitement adapté d'approche…

Subjects/Keywords: Asthme; Trouble panique; Asthmatiques; Attaques de panique; Bronchoconstriction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Boudreau, M. (2016). Réactivité bronchique aux tests de provocation respiratoire à la méthacholine et au dioxyde de carbone chez les patients asthmatiques avec et sans trouble panique. (Thesis). Université du Québec à Montréal. Retrieved from http://archipel.uqam.ca/8720/1/D3031.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Boudreau, Maxine. “Réactivité bronchique aux tests de provocation respiratoire à la méthacholine et au dioxyde de carbone chez les patients asthmatiques avec et sans trouble panique.” 2016. Thesis, Université du Québec à Montréal. Accessed March 02, 2021. http://archipel.uqam.ca/8720/1/D3031.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Boudreau, Maxine. “Réactivité bronchique aux tests de provocation respiratoire à la méthacholine et au dioxyde de carbone chez les patients asthmatiques avec et sans trouble panique.” 2016. Web. 02 Mar 2021.

Vancouver:

Boudreau M. Réactivité bronchique aux tests de provocation respiratoire à la méthacholine et au dioxyde de carbone chez les patients asthmatiques avec et sans trouble panique. [Internet] [Thesis]. Université du Québec à Montréal; 2016. [cited 2021 Mar 02]. Available from: http://archipel.uqam.ca/8720/1/D3031.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Boudreau M. Réactivité bronchique aux tests de provocation respiratoire à la méthacholine et au dioxyde de carbone chez les patients asthmatiques avec et sans trouble panique. [Thesis]. Université du Québec à Montréal; 2016. Available from: http://archipel.uqam.ca/8720/1/D3031.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Newcastle

5. Veerati, Punnam Chander. Role of mechanical forces in asthma pathogenesis.

Degree: PhD, 2019, University of Newcastle

URL: http://hdl.handle.net/1959.13/1404616

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Research Doctorate - Doctor of Philosophy (PhD)

Asthma is characterised by bronchoconstriction which leads to clinical symptoms and generates mechanical forces within the airway. During… (more)

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Research Doctorate - Doctor of Philosophy (PhD)

Asthma is characterised by bronchoconstriction which leads to clinical symptoms and generates mechanical forces within the airway. During virally induced asthma exacerbations, bronchoconstriction and viral infection occur simultaneously; these factors may interact in the airway leading to the apparent innate immune deficiencies demonstrated in some asthmatics. This lead to our overarching hypothesis that “airway compressive forces suppress innate immunity following viral infection in asthmatics”. To investigate this in <i>in-vitro</i> using a full experimental time course, there was a requirement for high cell numbers from individual patients with respiratory diseases such as asthma. Initially, we performed cell line optimisation to try to establish air-liquid interface (ALI) cultures. Later we used a conditionally reprogrammed (CR) technique on primary bronchial epithelial cells (pBECs) to proliferate indefinitely for extended passages and then used those at ALI. In order to investigate the effects of apical compression on cells during viral infection, we wished to use a model which as closely as possible mimicked human airway infection <i>in-vivo</i>. Therefore we developed a physiologically relevant RV1B infection model and demonstrated for the first time that ultra-low multiplicity of infection induces delayed innate immune responses from cells obtained from asthma and COPD donors in comparison to healthy controls. Here we used cells obtained from COPD donors along with asthma to investigate anti-viral responses; as previously it was shown that the anti-viral responses from COPD cells were also altered. In order to investigate the effect of bronchoconstriction on anti-viral responses, we exposed pBECs obtained from asthmatic donors, grown at ALI to apical compressive stress mimicking bronchoconstriction along with physiologically relevant RV infection. We examined the effect of mechanical forces occurring prior to infection (mimicking poorly controlled asthma), or during viral infection (mimicking virally induced asthma exacerbation). We demonstrate that apical compression suppresses innate immune responses from asthmatic pBECs under these conditions. Our data may explain why the patients with less well-controlled asthmatics appear more vulnerable to viral infection and why some asthmatics appear to have deficient Interferon (IFN) responses to natural infections.

Advisors/Committee Members: University of Newcastle. Faculty of Health & Medicine, School of Medicine and Public Health.

Subjects/Keywords: asthma; bronchoconstriction; mechanical forces; apical compression; rhinovirus; innate immunity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Veerati, P. C. (2019). Role of mechanical forces in asthma pathogenesis. (Doctoral Dissertation). University of Newcastle. Retrieved from http://hdl.handle.net/1959.13/1404616

Chicago Manual of Style (16^th Edition):

Veerati, Punnam Chander. “Role of mechanical forces in asthma pathogenesis.” 2019. Doctoral Dissertation, University of Newcastle. Accessed March 02, 2021. http://hdl.handle.net/1959.13/1404616.

MLA Handbook (7^th Edition):

Veerati, Punnam Chander. “Role of mechanical forces in asthma pathogenesis.” 2019. Web. 02 Mar 2021.

Vancouver:

Veerati PC. Role of mechanical forces in asthma pathogenesis. [Internet] [Doctoral dissertation]. University of Newcastle; 2019. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1959.13/1404616.

Council of Science Editors:

Veerati PC. Role of mechanical forces in asthma pathogenesis. [Doctoral Dissertation]. University of Newcastle; 2019. Available from: http://hdl.handle.net/1959.13/1404616

6. Butkutė, Rimantė. Kačių astmos etiologija, diagnostika ir gydymas.

Degree: Master, Veterinary Medicine, 2014, Lithuanian Academic Libraries Network (LABT)

URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_134150-65980 ;

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Baigiamojo darbo tikslas: išanalizuoti kačių astmos pasireiškimo dažnumą, ligos atsiradimo priežastis, dažniausiai taikomas diagnostines priemones ir gydymą. Apibūdinimas: kačių astma – tai galimai alerginės kilmės… (more)

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Baigiamojo darbo tikslas: išanalizuoti kačių astmos pasireiškimo dažnumą, ligos atsiradimo priežastis, dažniausiai taikomas diagnostines priemones ir gydymą. Apibūdinimas: kačių astma – tai galimai alerginės kilmės susirgimas, kurio metu atsiranda kvėpavimo takų uždegimas, padidėjusi gleivių sekrecija, spontaniška bronchokonstrikcija ir kvėpavimo takų remodeliacijos. Šie pokyčiai sukelia kosulį, dusulį, švokštimą ir kvėpavimo nepakankamumą. Dažniausiai praktikoje susiduriama su diagnostikos problematika. Baigiamojo darbo metodikos: tyrimas buvo atliekamas 2013 metais, jame dalyvavo 9 astma sergančios katės ir 5 sveikos katės. Buvo atlikta kačių, įtariamų sergant astma, šeimininkų apklausa, kurios metu vertinami galimai astmos pasireiškimui turėję įtakos veiksniai. Tuomet atliekamos kitos diagnostinės procedūros, kurių metu gaunama diagnozė, patvirtinanti kačių astmą ir skiriamas tolimesnis gydymas. Pagrindiniai tiriamojo darbo rezultatai ir išvados: kačių astma nėra dažnai pasitaikanti kvėpavimo takų liga. Tarp astma sergančių kačių nėra ženklių lyties skirtumų, 56 % sirgusiųjų sudarė patelės, o patinai – 44 %. Astma dažniau pasireiškė katėms, kurių amžius svyravo nuo 1 iki 5 metų (45 %) ir toms, kurios buvo negrynaveislės (45 %). Apklausos metu nustatyti pagrindiniai potencialūs astmą sukeliantys veiksniai, t.y. šeimininkų rūkymas (12 %), parfumuotų valiklių (12 %), oro gaiviklių bei dezodorantų (12 %) naudojimas katės gyvenamojoje aplinkoje. Astmos diagnostikoje takyti... [toliau žr. visą tekstą]

The aim: to analyze the manifestation frequency of feline asthma, diagnostic methods, treatment and identify the factors, which have influence in manifestation of this disease. Description: feline asthma has an allergic etiology. The hallmark features include airway inflammation, mucus hypersecretion, spontaneous bronchoconstriction and airway remodeling. These changes lead to clinical signs of cough, dyspnea, wheeze and respiratory distress. The diagnosis of asthma can be complicated, because there are no single test for diagnose feline asthma. Methodology: the study was carried out in a small animal clinic X in 2013 year. 9 asthmatic cats and 5 healthy cats were included in this study. There was composed questionnaire form for the owners, whose cats were possibly asthmatic. All the received material was used for statistic analysis about the factors, which had more impact in causing asthma. The other diagnostic manipulations were performed to get this certain diagnosis and find the best treatment options. There were reviewed epidemiology, clinical manifestations, patogenesis and factors, which influence asthma, blood results, diagnosis and treatment of feline asthma. Results and conclusions: feline asthma is not common respiratory disease in cats. The study revealed that there is no clear sex predilection (females – 56 % and males – 44 %). Middle-aged cats (1 to 5 years) were seen more affected (45 %). 45 % of the cats were mixed breed. The main asthma predisposing factors... [to full text]

Advisors/Committee Members: Jokimas, Juozas (Master’s degree committee chair), Šleiniūtė, Jūratė (Master’s degree session secretary), Grigonis, Aidas (Master’s degree committee member), Antanaitis, Ramūnas (Master’s degree committee member), Žymantienė, Judita (Master’s degree committee member), Ružauskas, Modestas (Master’s degree committee member), Šutovienė, Daiva (Master’s degree committee member), Skinkė, Lina (Master’s degree committee member), Zamokas, Gintaras (Master’s thesis supervisor).

Subjects/Keywords: Astma; Kvėpavimas; Bronchokonstrikcija; Alergija; Katės; Asthma; Respiratory; Bronchoconstriction; Allergy; Feline

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APA (6^th Edition):

Butkutė, Rimantė. (2014). Kačių astmos etiologija, diagnostika ir gydymas. (Masters Thesis). Lithuanian Academic Libraries Network (LABT). Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_134150-65980 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Chicago Manual of Style (16^th Edition):

Butkutė, Rimantė. “Kačių astmos etiologija, diagnostika ir gydymas.” 2014. Masters Thesis, Lithuanian Academic Libraries Network (LABT). Accessed March 02, 2021. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_134150-65980 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

MLA Handbook (7^th Edition):

Butkutė, Rimantė. “Kačių astmos etiologija, diagnostika ir gydymas.” 2014. Web. 02 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

Butkutė, Rimantė. Kačių astmos etiologija, diagnostika ir gydymas. [Internet] [Masters thesis]. Lithuanian Academic Libraries Network (LABT); 2014. [cited 2021 Mar 02]. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_134150-65980 ;.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Council of Science Editors:

Butkutė, Rimantė. Kačių astmos etiologija, diagnostika ir gydymas. [Masters Thesis]. Lithuanian Academic Libraries Network (LABT); 2014. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2014~D_20140305_134150-65980 ;

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

University of Ontario Institute of Technology

7. O???Neill, Carley. Comparing exercise responses to high intensity interval training between adults with and without asthma.

Degree: 2020, University of Ontario Institute of Technology

URL: http://hdl.handle.net/10155/1176

► Exercise induced bronchoconstriction (EIBC) occurs in response to high ventilations during exercise, which cools and dries the airways, triggering an inflammatory cascade. High intensity interval… (more)

▼ Exercise induced bronchoconstriction (EIBC) occurs in response to high ventilations during exercise, which cools and dries the airways, triggering an inflammatory cascade. High intensity interval training (HIIT) is associated with reductions in inflammation, improvements in cardiorespiratory outcomes, and mental health in healthy adults; however, the impact of HIIT in adults with EIBC is unclear. The purpose of this dissertation was to determine the impact of a 6-week HIIT intervention on physiological (e.g. inflammation, ventilation, and cardiorespiratory fitness) and psychological (i.e. anxiety) domains of health among adults with EIBC and healthy adults, and the impact of HIIT on clinical outcomes (i.e. asthma control) among adults with EIBC. METHODS: A quasi-experimental study design was used. A 6-week HIIT intervention was implemented in adults (18-44 years) with EIBC and healthy controls. Sessions were conducted three times per week and consisted of cycling at 10% PPO for 1 minute followed by 90% PPO for 1 minute, repeated 10 times. Primary measures at pre (T1) and post-intervention (T2) included: 1) maximal exercise test 2) passive drool saliva samples 3) anxiety sensitivity index-3 4) asthma control questionnaire-7 (EIBC group only). RESULTS: Participants in the EIBC group (n=20; T1: 32.9 ?? 8.0; T2: 38.6 ?? 8.2 ml/kg/min, p<0.01) and control group (n=12; T1: 38.6 ?? 8.2; T2: 38.9 ?? 12.3 ml/kg/min, p<0.01) improved VO2max. Adults with EIBC had lower levels of IL-1Ra at T2 when compared to healthy controls (EIBC T2: 0.2 ?? 0.16pg/ug protein; Control T2: 0.8 ?? 0.21pg/ug protein; p<0.01, hp2 = 0.3). Maximal ventilation in the EIBC group did not improve (EIBC T1: 97.8 ?? 22.2; EIBC T2: 108.7 ?? 29.5, p=0.7, Cohens d=0.4); however, the control group improved ventilation at the same absolute exercise workload (Control T1: 82.8 ?? 20.1; Control T2: 101.8 ?? 18.1, p=0.02). Reductions in anxiety sensitivity (EIBC T1: 17.9 ?? 11.8; EIBC T2: 12.4 ?? 13, p=0.002, Cohens d=0.4) and asthma control (EIBC T1: 0.8 ?? 0.6; EIBC T2: 0.5 ?? 0.4, p=0.02, Cohens d=0.5) from T1 to T2 occurred. CONCLUSION: A 6- week HIIT intervention leads to improvements in physiological, psychological, and clinical outcomes among adults with EIBC. Advisors/Committee Members: Dogra, Shilpa.

Subjects/Keywords: Exercise; Asthma; High Intensity Interval Training; Exercise Induced Bronchoconstriction

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APA (6^th Edition):

O???Neill, C. (2020). Comparing exercise responses to high intensity interval training between adults with and without asthma. (Thesis). University of Ontario Institute of Technology. Retrieved from http://hdl.handle.net/10155/1176

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

O???Neill, Carley. “Comparing exercise responses to high intensity interval training between adults with and without asthma.” 2020. Thesis, University of Ontario Institute of Technology. Accessed March 02, 2021. http://hdl.handle.net/10155/1176.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

O???Neill, Carley. “Comparing exercise responses to high intensity interval training between adults with and without asthma.” 2020. Web. 02 Mar 2021.

Vancouver:

O???Neill C. Comparing exercise responses to high intensity interval training between adults with and without asthma. [Internet] [Thesis]. University of Ontario Institute of Technology; 2020. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10155/1176.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

O???Neill C. Comparing exercise responses to high intensity interval training between adults with and without asthma. [Thesis]. University of Ontario Institute of Technology; 2020. Available from: http://hdl.handle.net/10155/1176

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Ontario Institute of Technology

8. O'Neill, Carley. The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction.

Degree: 2016, University of Ontario Institute of Technology

URL: http://hdl.handle.net/10155/711

► INTRODUCTION: Exercise induced bronchoconstriction (EIBC) occurs as a result of airway cooling and drying in adults with airway hyperresponsiveness (AHR). Continuous exercise leads to a… (more)

Subjects/Keywords: Bronchoconstriction; High intensity interval exercise; Lung function; Affect; Perceived exertion

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

O'Neill, C. (2016). The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction. (Thesis). University of Ontario Institute of Technology. Retrieved from http://hdl.handle.net/10155/711

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

O'Neill, Carley. “The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction.” 2016. Thesis, University of Ontario Institute of Technology. Accessed March 02, 2021. http://hdl.handle.net/10155/711.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

O'Neill, Carley. “The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction.” 2016. Web. 02 Mar 2021.

Vancouver:

O'Neill C. The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction. [Internet] [Thesis]. University of Ontario Institute of Technology; 2016. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10155/711.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

O'Neill C. The acute response to high intensity interval exercise in adults with exercise induced bronchoconstriction. [Thesis]. University of Ontario Institute of Technology; 2016. Available from: http://hdl.handle.net/10155/711

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

9. Blažetić, Karlo. Utjecaj eikosanoida na kontrakciju i relaksaciju glatkih mišića respiratornog puta.

Degree: 2020, Univerza v Mariboru

URL: https://dk.um.si/IzpisGradiva.php?id=75860 ; https://dk.um.si/Dokument.php?id=140745&dn= ; https://plus.si.cobiss.net/opac7/bib/18062595?lang=sl

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Eikosanoidi su metaboliti arahidonske kiseline. Između njih prostaglandini i leukotrieni imaju najvažnije biološke učinke i uloge u organizmu. Jedna od tih uloga je kontrakcija/relaksacija glatkih… (more)

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Eikosanoidi su metaboliti arahidonske kiseline. Između njih prostaglandini i leukotrieni imaju najvažnije biološke učinke i uloge u organizmu. Jedna od tih uloga je kontrakcija/relaksacija glatkih mišića respiratornog sustava. Tako je dereguliranjem produkcije eikosanoida moguća bronhokonstrikcija kod astme. U ovom radu usredotočujemo se na ovisnost sile glatkih mišića različitih tkiva iz različitih subjekata, čovjeka i životinja o različitim vrstama eikosanoida. Opisat ćemo mehanizme nastanka eikosanoida, receptore preko kojih oni djeluju te njihovu funkciju. Analizirali smo mjerenja kontrakcije i relaksacije glatkih mišića dišnih putova pod utjecajem različitih eikosanoida. Među ljudskim tkivima analizirane su sile razvijene u glatkim mišićima bronha, malih dišnih puteva te plućnog parenhima. Kod životinjskog modela uzeti su uzorci tkiva glatkih mišića s dušnika miša te zamorca. Digitalizacijom mjerenja obradili smo podatke iz različitih znanstvenih članaka. Koristeći računalni program Origin 8.5 s alatom Digitizer, digitalizirali smo ovisnosti dišnih putova glatkih mišića različitih organizama o koncentracijama eikosanoida i drugih kontraktilnih agonista te odredili parametre tih ovisnosti prilagođavanjem različitih odabranih matematičkih funkcija (različiti oblici Hill funkcije). Napravili smo usporedbu parametara između različitih organizama i između mjerenja različitih autora. Nadalje, usporedili smo jačine eikosanoidne kontrakcije s drugim fiziološkim kontraktilnim agonistima i na kraju objasnili je li moguće prenijeti podatke izmjerene na životinjama u fizikalno-matematičke modele, koji simuliraju procese kod ljudi.

Eicosanoids are the metabolites of arachidonic acid. Among them prostaglandins and leukotrienes have the most important biological activities and roles in the human organism. One of these roles is related to the contraction/relaxation of smooth muscles, especially in airways. Their dysregulation in production may lead to bronchoconstriction in asthma. Here we focus on the relationship of the developed force in airway smooth muscle cells taken from different tissues and from different subjects, human and animal, with respect to different eicosanoids. First, the mechanisms of the production of eicosanoids, their action through receptors and their function is described. The main goal was to analyse the measurements of the developed force in airway smooth muscles with respect to different eicosanoids, either contractile or relaxing. In case of human tissues, we analysed the developed force in smooth muscles of bronchi, small airways and the pulmonary parenchyma. In case of animals, the analysis was performed for the smooth muscles of the mouse and guinea pig tracheas. For this purpose we first digitized measured dependencies of forces versus eicosanoid concentrations with the Digitizer tool within the computer program Origin 8.5. Then we fitted these dependencies with different forms of Hill functions and determined the parameter values within these functions. Further, we compared these…

Advisors/Committee Members: Fajmut, Aleš.

Subjects/Keywords: prostaglandini; leukotrieni; arahidonska kiselina; bronhokonstrikcija; digitalizacija.; prostaglandins; leukotrienes; arachidonic acid; bronchoconstriction; digitization.; info:eu-repo/classification/udc/577:616.2:519.87(043.2)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Blažetić, K. (2020). Utjecaj eikosanoida na kontrakciju i relaksaciju glatkih mišića respiratornog puta. (Masters Thesis). Univerza v Mariboru. Retrieved from https://dk.um.si/IzpisGradiva.php?id=75860 ; https://dk.um.si/Dokument.php?id=140745&dn= ; https://plus.si.cobiss.net/opac7/bib/18062595?lang=sl

Chicago Manual of Style (16^th Edition):

Blažetić, Karlo. “Utjecaj eikosanoida na kontrakciju i relaksaciju glatkih mišića respiratornog puta.” 2020. Masters Thesis, Univerza v Mariboru. Accessed March 02, 2021. https://dk.um.si/IzpisGradiva.php?id=75860 ; https://dk.um.si/Dokument.php?id=140745&dn= ; https://plus.si.cobiss.net/opac7/bib/18062595?lang=sl.

MLA Handbook (7^th Edition):

Blažetić, Karlo. “Utjecaj eikosanoida na kontrakciju i relaksaciju glatkih mišića respiratornog puta.” 2020. Web. 02 Mar 2021.

Vancouver:

Blažetić K. Utjecaj eikosanoida na kontrakciju i relaksaciju glatkih mišića respiratornog puta. [Internet] [Masters thesis]. Univerza v Mariboru; 2020. [cited 2021 Mar 02]. Available from: https://dk.um.si/IzpisGradiva.php?id=75860 ; https://dk.um.si/Dokument.php?id=140745&dn= ; https://plus.si.cobiss.net/opac7/bib/18062595?lang=sl.

Council of Science Editors:

Blažetić K. Utjecaj eikosanoida na kontrakciju i relaksaciju glatkih mišića respiratornog puta. [Masters Thesis]. Univerza v Mariboru; 2020. Available from: https://dk.um.si/IzpisGradiva.php?id=75860 ; https://dk.um.si/Dokument.php?id=140745&dn= ; https://plus.si.cobiss.net/opac7/bib/18062595?lang=sl

McMaster University

10. Hernandez, Jeremy M. ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS.

Degree: PhD, 2011, McMaster University

URL: http://hdl.handle.net/11375/11524

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Asthma is a disease characterized by transient airway smooth muscle contraction leading to episodes of reversible airway narrowing. It affects over 300 million people… (more)

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Asthma is a disease characterized by transient airway smooth muscle contraction leading to episodes of reversible airway narrowing. It affects over 300 million people worldwide and is implicated in over 250 000 deaths annually. The primary clinical features of asthma include airway inflammation, hyperresponsiveness, and remodeling. Generally, asthmatic patients experience exacerbations between periods of diminished symptoms. Interestingly, in addition to these above mentioned hallmarks, asthmatics have also been shown to react differently to ventilatory mechanical strain. This is most evident when assessing the effect of a deep inspiration (DI), clinically measured as a breath taken from functional residual capacity to total lung capacity, in healthy individuals versus asthmatics. These deep inspiratory efforts have been shown to produce a bronchodilatory response in healthy individuals, whereas in asthmatics, DIs are less effective in producing bronchodilation, can cause more rapid airway re-narrowing, and even bronchoconstriction in moderate to severe asthmatics. The mechanism by which a DI is able to cause bronchoconstriction remains ambiguous. Previous theories suggest that this phenomenon is intrinsic to airway smooth muscle (ASM) itself. However, the airway inflammation present in asthmatic airways may also add to the increased ASM contractility following stretch, by the release of mediators that can prime the contractile apparatus to react excessively in the presence of stretch. Thus, collectively, the studies contained in this thesis are linked to the general theme of greater characterization of the signalling mechanisms that regulate airway stretch-activated contractions using a pharmacological approach in intact bovine bronchial segments, with the hope of providing novel insights into the mechanisms that regulate the DI-induced bronchoconstriction seen in asthmatics.

Doctor of Philosophy (Medical Science)

Advisors/Committee Members: Janssen, Luke J., Inman, Mark, Cox, Gerard, Medical Sciences (Division of Physiology/Pharmacology).

Subjects/Keywords: asthma; airway smooth muscle contraction; deep inspiration; bronchoconstriction; airway stretch; airway hyperresponsiveness; Circulatory and Respiratory Physiology; Medical Physiology; Physiological Processes; Respiratory Tract Diseases; Circulatory and Respiratory Physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hernandez, J. M. (2011). ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS. (Doctoral Dissertation). McMaster University. Retrieved from http://hdl.handle.net/11375/11524

Chicago Manual of Style (16^th Edition):

Hernandez, Jeremy M. “ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS.” 2011. Doctoral Dissertation, McMaster University. Accessed March 02, 2021. http://hdl.handle.net/11375/11524.

MLA Handbook (7^th Edition):

Hernandez, Jeremy M. “ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS.” 2011. Web. 02 Mar 2021.

Vancouver:

Hernandez JM. ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS. [Internet] [Doctoral dissertation]. McMaster University; 2011. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/11375/11524.

Council of Science Editors:

Hernandez JM. ASPECTS OF AIRWAY STRETCH-ACTIVATED CONTRACTIONS ASSESSED IN PERFUSED INTACT BOVINE BRONCHIAL SEGMENTS. [Doctoral Dissertation]. McMaster University; 2011. Available from: http://hdl.handle.net/11375/11524

The Ohio State University

11. Al Wabel, Naser Ali. Acute induction of tracheo-bronchoconstriction in morphine/chloralose anesthetized dogs: physiological approach and principles of therapy.

Degree: PhD, Veterinary Biosciences, 2003, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1069557474

► The respiratory system serves as a functional gas exchanger which, under neural control, contributes greatly to homeostasis. This study was designed to evoke tracheo-bronchoconstriction by… (more)

▼ The respiratory system serves as a functional gas exchanger which, under neural control, contributes greatly to homeostasis. This study was designed to evoke tracheo-bronchoconstriction by different stimuli and to study the respiratory and hemodynamic effects of three bronchodilators. Tracheo-bronchoconstriction was induced in morphine/chloralose-anesthetized dogs by 5% CO2, 10% O2 or intravenous bethanechol (0.5 mg/kg). Hypercapnia caused no significant (p>0.01) respiratory or hemodynamic effects. Hypoxia significantly (p<0.01) increased heart rate (HR), pulmonary artery pressure (Pap), cardiac output (CO), and peripheral vascular resistance (PVR). No significant changes were observed in left ventricular end-diastolic pressure (LVEDP), tracheal pressure (Tp), airway pressure (Paw), bronchial pressure (Brp), and pulmonary compliance (PC) due to hypoxia. Changes due to gas mixtures were transient and returned to baseline upon normal respiration. In contrast, bethanechol caused significant increases in Pap, LVEDP, PVR, Tp and Paw with no significant changes in HR, CO or Brp. Compared to gas mixtures, bethanechol produced greater respiratory and hemodynamic effects that may resemble asthma and chronic obstructive pulmonary disease. Four groups of dogs were used to compare the respiratory and hemodynamic effects of aminophylline, atropine, terbutaline, or saline control on bethanechol-induced bronchoconstriction. Both atropine (0.04 mg/kg) and aminophylline (20 mg/kg) increased HR significantly (p<0.006) compared to control. Atropine, starting at 0.02 mg/kg, significantly decreased the bethanechol-elevated Pap, with no changes in the other groups. Atropine (0.02 mg/kg) and aminophylline (20 mg/kg) significantly decreased LVEDP after bethanechol. Atropine decreased 65% of the elevated Tp compared to 47%, and 12.6% for terbutaline, and aminophylline, respectively. Only terbutaline significantly decreased Paw and increased PC. No significant changes were observed in CO, PVR, Brp, or in blood and end-tidal gases after any bronchodilator. The high efficacy of atropine in reversing bethanechol-induced tracheo-bronchial spasm suggests a dominant control of respiration by the parasympathetic system. With limitations, this model might be of benefit in evaluating the mechanism of other bronchodilators that alter autonomic nervous control, such as M3-selective antimuscarinics. Advisors/Committee Members: Hamlin, Dr. Robert (Advisor).

Subjects/Keywords: Tracheo-bronchoconstriction; Bethanechol; Bronchodilators; Morphine/chloralose; Dog; Asthma; COPD; Hemodynamic

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Al Wabel, N. A. (2003). Acute induction of tracheo-bronchoconstriction in morphine/chloralose anesthetized dogs: physiological approach and principles of therapy. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1069557474

Chicago Manual of Style (16^th Edition):

Al Wabel, Naser Ali. “Acute induction of tracheo-bronchoconstriction in morphine/chloralose anesthetized dogs: physiological approach and principles of therapy.” 2003. Doctoral Dissertation, The Ohio State University. Accessed March 02, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1069557474.

MLA Handbook (7^th Edition):

Al Wabel, Naser Ali. “Acute induction of tracheo-bronchoconstriction in morphine/chloralose anesthetized dogs: physiological approach and principles of therapy.” 2003. Web. 02 Mar 2021.

Vancouver:

Al Wabel NA. Acute induction of tracheo-bronchoconstriction in morphine/chloralose anesthetized dogs: physiological approach and principles of therapy. [Internet] [Doctoral dissertation]. The Ohio State University; 2003. [cited 2021 Mar 02]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1069557474.

Council of Science Editors:

Al Wabel NA. Acute induction of tracheo-bronchoconstriction in morphine/chloralose anesthetized dogs: physiological approach and principles of therapy. [Doctoral Dissertation]. The Ohio State University; 2003. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1069557474

12. Carlos Tiago Martins Moura. ParticipaÃÃo dos canais de cÃlcio na hiperreatividade induzida por ovalbumina em traquÃias isoladas de ratos.

Degree: Master, 2004, Universidade Federal do Ceará

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=244 ;

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Com o objetivo de verificar a interferÃncia da broncoprovocaÃÃo antigÃnica sobre a contratilidade traqueal, ratos machos (250 -350 g) foram sensibilizados Ã ovalbumina (OVA) e,… (more)

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Com o objetivo de verificar a interferÃncia da broncoprovocaÃÃo antigÃnica sobre a contratilidade traqueal, ratos machos (250 -350 g) foram sensibilizados Ã ovalbumina (OVA) e, 13 a 14 dias depois, desafiados em intervalos de 15 minutos atravÃs da inalaÃÃo do antÃgeno sensibilizante (OVA, 1 mg/ml, seguida de 5 mg/ml). O sacrifÃcio dos animais foi feito imediatamente (SD0) ou 24 horas (SD24) apÃs o desafio antigÃnico atravÃs de anestesia com hidrato de cloral (0,4 g/Kg). Alguns animais foram tratados com metilsergida (1 mg/Kg) 40 minutos antes do desafio. Os animais controle (CONT) inalaram apenas o veÃculo (NaCl 0,9 %). A traquÃia foi removida e montada em cuba para orgÃo isolado contendo 10 ml de soluÃÃo de Krebs-Henseleit modificada (mantida a 37Â0,5 °C) e aerada com mistura carbogÃnica (O2/CO2â95:5). Foram confeccionadas curvas concentraÃÃo-efeito (CCE) para cloreto de potÃssio (KCl), acetilcolina (ACh) ou serotonina (5-HT). Em outros experimentos foram realizadas CCE ao Ca2+ em preparaÃÃes mantidas previamente em soluÃÃo sem Ca2+ (contendo 10-5 M de EDTA, nifedipina e indometacina, 10-6 M para ambas) e estimuladas por KCl, ACh ou 5-HT. A sensibilizaÃÃo e o posterior desafio antigÃnico (SD) promoveram um significativo aumento da resposta mÃxima (RM) das CCE ao KCl (forÃa em grama, mÃdia Â E.P.M.: CONT = 0,52 Â 0,01; SD24 = 1,22 Â 0,03; n = 06; p < 0,01), Ã ACh (CONT = 2,11 Â 0,10; SD24 = 3,53 Â 0,03; n = 06; p < 0,01) ou Ã 5-HT (CONT = 0,60 Â 0,03; SD24 = 1,48 Â 0,09; n = 06; p < 0,01). As traquÃias de animais sensibilizados e desafiados apresentaram aumento da RM ao Ca2+ apenas quando prÃ-contraÃdas com KCl (CONT = 0,84 Â 0,08; SD24 = 1,98 Â 0,05; n = 6; p < 0,01) ou ACh (CONT = 0,98 Â 0,09; SD24 = 1,54 Â 0,15; n = 6; p < 0,05). Quando o agonista utilizado foi a 5-HT esta diferenÃa nÃo ocorreu, sendo observada uma maior RM somente na ausÃncia de nifedipina (CONT = 0,81 Â 0,06; SD24 sem nifedipina = 1,23 Â 0,08; n = 05; p < 0,01). Foram comparados os animais apenas sensibilizados e nÃo desafiados (SENS) com os SD na presenÃa de Ãcido niflÃmico (AN). O AN inibiu a hiperreatividade para a 5-HT induzida pelo desafio antigÃnico (SENS = 1,28 Â 0,09; SD24 + AN = 1,01 Â 0,08; n = 05), enquanto que foi ineficaz em inibir a hiperreatividade para a ACh (SENS = 1,44 Â 0,01; SD24 + NA = 1,67 Â 0,03; n = 05; p < 0,01). Portanto, os resultados mostram que hÃ envolvimento de canais de Ca2+, tanto dependentes de voltagem (VOC) como operados por receptor (ROC), na hiperreatividade do mÃsculo liso respiratÃrio, induzida pela reapresentaÃÃo do antÃgeno a animais previamente sensibilizados e que o desenvolvimento da hiperreatividade para a 5-HT estÃ relacionado Ã abertura de canais de Cl- ativados por Ca2+

In order to verify the interference of the antigenic challenge on traqueal contractility in vitro, male rats (250 -350 g) were ovalbumine (OVA)-sensitized and, 13 to 14 days later, they were challenged through the sensitizing antigen inhalation (OVA, 1 mg/ml, followed by 5 mg/ml). Animals were sacrificed immediately (SD0) or…

Advisors/Committee Members: ArmÃnio Aguiar dos Santos, FlÃvia Almeida Santos, Pedro Jorge Caldas MagalhÃes, Francisco Ruy Capaz.

Subjects/Keywords: FARMACOLOGIA; Canais IÃnicos; Hipersencibilidade RespiratÃria; BroncoconstriÃÃo; InflamaÃÃo; Ion Channels; Respiratory Hipersencibilidade; Bronchoconstriction; Inflammation; Ovalbumina; Asma; DoenÃas RespiratÃrias; Ratos

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APA (6^th Edition):

Moura, C. T. M. (2004). ParticipaÃÃo dos canais de cÃlcio na hiperreatividade induzida por ovalbumina em traquÃias isoladas de ratos. (Masters Thesis). Universidade Federal do Ceará. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=244 ;

Chicago Manual of Style (16^th Edition):

Moura, Carlos Tiago Martins. “ParticipaÃÃo dos canais de cÃlcio na hiperreatividade induzida por ovalbumina em traquÃias isoladas de ratos.” 2004. Masters Thesis, Universidade Federal do Ceará. Accessed March 02, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=244 ;.

MLA Handbook (7^th Edition):

Moura, Carlos Tiago Martins. “ParticipaÃÃo dos canais de cÃlcio na hiperreatividade induzida por ovalbumina em traquÃias isoladas de ratos.” 2004. Web. 02 Mar 2021.

Vancouver:

Moura CTM. ParticipaÃÃo dos canais de cÃlcio na hiperreatividade induzida por ovalbumina em traquÃias isoladas de ratos. [Internet] [Masters thesis]. Universidade Federal do Ceará 2004. [cited 2021 Mar 02]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=244 ;.

Council of Science Editors:

Moura CTM. ParticipaÃÃo dos canais de cÃlcio na hiperreatividade induzida por ovalbumina em traquÃias isoladas de ratos. [Masters Thesis]. Universidade Federal do Ceará 2004. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=244 ;

13. Head, Sally K. The Effect of Omega-3 Fatty Acids on Airway Inflammation, Hyperpnea-Induced Bronchoconstriction, and Airway Smooth Muscle Contractility in Asthma.

Degree: 2012, IUPUI

URL: http://hdl.handle.net/1805/2752

►

Indiana University-Purdue University Indianapolis (IUPUI)

Asthma, a chronic inflammatory disease of the airways, affects nearly 25 million Americans. The vast majority of these patients suffer… (more)

▼

Indiana University-Purdue University Indianapolis (IUPUI)

Asthma, a chronic inflammatory disease of the airways, affects nearly 25 million Americans. The vast majority of these patients suffer from exercise-induced bronchoconstriction (EIB), a complication of asthma. Although traditionally treated pharmacologically, nutritional strategies provide a promising alternative for managing EIB as the prevalence of asthma may be due in part to changes in diet. Our objective was to determine the effects of novel nutritional strategies on hyperpnea-induced bronchoconstriction (HIB) in asthmatic individuals. HIB uses rapid breathing to identify EIB in a research or clinical setting. Fish oil, a combination of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docsahexaenoic acid (DHA), has been shown to be effective in suppressing EIB. However, its use in combination with other nutritional supplements, the optimal fish oil formula, and its effect on smooth muscle contractility have not been fully explored. An in vivo study (study 1) was conducted in individuals with both asthma and HIB to determine whether a combination of fish oil and vitamin C was more effective than either one alone in alleviating HIB. Pulmonary function was significantly improved with both fish oil and the combination treatment but not with vitamin C alone. In study 2, individuals with both asthma and HIB were supplemented with DHA alone since the optimal formula for fish oil has yet to be ascertained; previous in vitro studies have suggested DHA may be the more potent omega-3 fatty acid in fish oil. However, no significant changes in pulmonary function or airway inflammation were seen with DHA supplementation. For study 3, canine airway smooth muscle tissue was treated with fish oil to determine the in vitro effect of fish oil on smooth muscle contractility. Acute treatment with fish oil relaxed smooth muscle strips that had been contracted with 5-hydroxytryptamine. These minor relaxations in smooth muscle tension with fish oil may represent significant changes at the level of the smaller airways. These studies have confirmed that fish oil represents a viable treatment modality for asthmatic individuals with EIB and suggest that fish oil may influence airway smooth muscle contractility.

Advisors/Committee Members: Mickleborough, Timothy D., Gunst, Susan J., Harrington, Maureen A., Sturek, Michael Stephen, Tepper, Robert S., Tune, Johnathan D..

Subjects/Keywords: Asthma; Bronchoconstriction; Fish Oil; Asthma – Treatment – Research; Fish oils – Therapeutic use; Smooth muscle – Contraction

…constriction in hyperpnea-induced bronchoconstriction ......................25 Figure 2-1. Schematic… …constriction in hyperpnea-induced bronchoconstriction ....................176 xviii CHAPTER 1… …exercise-induced bronchoconstriction as compared to those without it (29). 4… …Exercise-Induced Bronchoconstriction Exercise-induced bronchoconstriction (EIB) is a… …Exercise-Induced Bronchoconstriction Currently, there are two major schools of thought on the…

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APA (6^th Edition):

Head, S. K. (2012). The Effect of Omega-3 Fatty Acids on Airway Inflammation, Hyperpnea-Induced Bronchoconstriction, and Airway Smooth Muscle Contractility in Asthma. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/2752

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Head, Sally K. “The Effect of Omega-3 Fatty Acids on Airway Inflammation, Hyperpnea-Induced Bronchoconstriction, and Airway Smooth Muscle Contractility in Asthma.” 2012. Thesis, IUPUI. Accessed March 02, 2021. http://hdl.handle.net/1805/2752.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Head, Sally K. “The Effect of Omega-3 Fatty Acids on Airway Inflammation, Hyperpnea-Induced Bronchoconstriction, and Airway Smooth Muscle Contractility in Asthma.” 2012. Web. 02 Mar 2021.

Vancouver:

Head SK. The Effect of Omega-3 Fatty Acids on Airway Inflammation, Hyperpnea-Induced Bronchoconstriction, and Airway Smooth Muscle Contractility in Asthma. [Internet] [Thesis]. IUPUI; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1805/2752.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Head SK. The Effect of Omega-3 Fatty Acids on Airway Inflammation, Hyperpnea-Induced Bronchoconstriction, and Airway Smooth Muscle Contractility in Asthma. [Thesis]. IUPUI; 2012. Available from: http://hdl.handle.net/1805/2752

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

East Carolina University

14. Wang, Xiaojia. Circadian activation of mast cells mediates the nocturnal response in allergic asthma.

Degree: PhD, Physiology, 2010, East Carolina University

URL: http://hdl.handle.net/10342/2962

► Circadian rhythm is a conserved physiological feature of most organisms. Nocturnal symptoms are a common feature of allergic asthma in humans. Patients with nocturnal asthma… (more)

▼ Circadian rhythm is a conserved physiological feature of most organisms. Nocturnal symptoms are a common feature of allergic asthma in humans. Patients with nocturnal asthma show circadian variation of their pulmonary function and inflammation, but nocturnal asthmatic responses have not been documented in animal models. In this study we tested the hypotheses that house dust mite (HDM) allergen-sensitive nonhuman primates (NHP) manifest nocturnal symptoms, and whether intrinsic circadian activity in mast cells might underlie nocturnal asthma response. Dynamic compliance (C_dyn) and lung resistance (R_L) measured as indicators of bronchoconstriction in anesthetized NHP, at rest and following exposure to HDM allergen, methacholine, and albuterol, were highly correlated with 3 respiratory inductive plethysmography (RIP) parameters: Phase Angle of the rib cage and abdomen waveforms (PhAng), Baseline Effort Phase Relation (eBPRL) and Effort Phase Relation (ePhRL). 21 allergic subjects were challenged with HDM early in the morning, and eBPRL and ePhRL were monitored for 20 hours after provocation. 15 of the allergic subjects exhibited gradual increases in eBPRL and ePhRL between midnight and 6 AM, with peak activity at 4 AM. The results demonstrate that animals exhibiting acute responses to allergen exposure during the day also exhibit nocturnal airway obstruction, possibly resulting from bronchoconstriction. Mast cells are central effector cells in asthma, and were subsequently investigated for intrinsic circadian activity that could underlie nocturnal asthma responses. Bone marrow derived mast cells (BMMCs) were exposed to high concentrations of serum (serum shocked) to synchronize gene expression. Following serum shock, circadian genes (mPer2, Bmal1, Rev-erbÃ¡, and Dbp) exhibit oscillations for up to 72 hours. Likewise, the high affinity IgE receptor in BMMCs (FcÃ¥RIÃ¡) exhibited circadian expression. The fcer1a gene and FcÃ¥RIÃ¡ protein following serum shock exhibited mean periods of 18.9 and 28.6 hours, respectively. Synchronized BMMCs stimulated with IgE/Ag at different circadian time display circadian rhythms in IL-13 mRNA. Taken together, synchronized BMMCs suggest an underlying circadian mechanism of nocturnal asthma in vitro.Â Â Advisors/Committee Members: Van Scott, Michael (advisor).

Subjects/Keywords: Health Sciences, Immunology; Circadian Rhythm; Allergens; Asthma; Pyroglyphidae; Plethysmography; Airway Obstruction; Bronchoconstriction; Bronchoconstrictor Agents; Methacholine Chloride; Albuterol; Sleep – physiology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, X. (2010). Circadian activation of mast cells mediates the nocturnal response in allergic asthma. (Doctoral Dissertation). East Carolina University. Retrieved from http://hdl.handle.net/10342/2962

Chicago Manual of Style (16^th Edition):

Wang, Xiaojia. “Circadian activation of mast cells mediates the nocturnal response in allergic asthma.” 2010. Doctoral Dissertation, East Carolina University. Accessed March 02, 2021. http://hdl.handle.net/10342/2962.

MLA Handbook (7^th Edition):

Wang, Xiaojia. “Circadian activation of mast cells mediates the nocturnal response in allergic asthma.” 2010. Web. 02 Mar 2021.

Vancouver:

Wang X. Circadian activation of mast cells mediates the nocturnal response in allergic asthma. [Internet] [Doctoral dissertation]. East Carolina University; 2010. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10342/2962.

Council of Science Editors:

Wang X. Circadian activation of mast cells mediates the nocturnal response in allergic asthma. [Doctoral Dissertation]. East Carolina University; 2010. Available from: http://hdl.handle.net/10342/2962

15. Emeršič, Tadej. Modelna napoved forsiranega izdihanega volumna v prvi sekundi (FEV1) pred in po zaužitju nesteroidnih antirevmatikov.

Degree: 2015, Univerza v Mariboru

URL: https://dk.um.si/IzpisGradiva.php?id=54146 ; https://dk.um.si/Dokument.php?id=79295&dn= ; https://plus.si.cobiss.net/opac7/bib/21565960?lang=sl

► Skupina zdravil nesteroidni antirevmatiki (NSAR) lahko po zaužitju pri posameznih osebah povzroči značilne klinične znake, poznane kot aspirinska intoleranca. Astmatika, ki je preobčutljiv na NSAR… (more)

▼ Skupina zdravil nesteroidni antirevmatiki (NSAR) lahko po zaužitju pri posameznih osebah povzroči značilne klinične znake, poznane kot aspirinska intoleranca. Astmatika, ki je preobčutljiv na NSAR in ima dva značilna klinična znaka – bronhokonstrikcijo in nosne polipe, imenujemo aspirinsko intolerantni astmatik. Za pojav aspirinske intolerance je ključna razgradnja arahidonske kisline (AA) v belih krvnih celicah. V splošnem ta poteka po ciklooksigenazni in lipoksigenazni poti. Po prvi poti se tvorijo prostanoidi, po drugi pa cisteinil levkotrieni. NSAR učinkujejo na ciklooksigenazno pot tako, da inhibirajo encime in posledično zmanjšujejo produkcijo prostanoidov, kar naj bi vodilo do povišanja produkcije cisteinil levkotrienov. Znižana produkcija prostanoidov in zvišana produkcija cisteinil levkotrienov sta tipični značilnosti aspirinske intolerance na metabolomski ravni. Raziskave, ki ločujejo aspirinsko intolerantne astmatike od aspirinsko tolerantnih astmatikov in neastmatikov, potekajo na različnih nivojih človeškega organizma. Na proteomskem nivoju potekajo raziskave v smeri študija razlik v ekspresiji posameznih ključnih encimov v metabolni mreži AA, na metabolomskem nivoju pa potekajo raziskave v smeri meritev in analize razmerij med posameznimi eikozanoidi. Raziskave na nivoju tkiv in organov so usmerjene v določanje povečane bronhialne reaktivnosti in preobčutljivosti pacientov na vrste in doze NSAR. To se izvaja s t. i. provokacijskimi testi, pri čemer se s spirometrijo meri forsirani izdihani volumen zraka v prvi sekundi (FEV1). V magistrski nalogi smo s fizikalno-matematičnim modelom povezali proteomski in metabolomski nivo na ravni celice ter napovedali dogajanje na ravni tkiva in organa virtualnega pacienta. Na celičnem nivoju smo z modelom napovedali koncentracije eikozanoidov za različna stanja ekspresij ključnih encimov v procesu metabolizma AA, ki bi naj karakterizirale različne skupine in podskupine pacientov – neastmatike ter astmatike tolerantne in intolerantne na aspirin. Na podlagi teh rezultatov smo najprej na celičnem nivoju napovedali razvito silo v gladkih mišičnih celicah dihalnih poti, nato pa še polmer tipične dihalne poti in končno FEV1. Vse izračune smo izvedli v bazalnem stanju (tj. brez zaužitega zdravila) in po simulaciji oralnega zaužitja različnih vrst NSAR z različnimi dozami. Z modelom smo določili mejne doze simuliranih NSAR (indometacina, ibuprofena, naproksena in celecoxiba) in paracetamola ter ovrednotili njihovo potentnost v smislu povzročitve bronhokonstrikcije in tveganja astmatičnega napada pri različnih modelnih populacijah aspirinsko intolerantnih astmatikov. Vse modelne simulacije smo izvedli v dveh modelnih stanjih. Prvo simulira stanje neinflamacije, drugo pa stanje inflamacije. Na tak način smo z modelom napovedali in simulirali, kako bi se individualni pacient ali skupina pacientov z razpoznavnim vzorcem v produkciji eikozanoidov in z značilnimi razlikami v ekspresiji posameznih ključnih encimov v metabolni mreži AA lahko odzivali na NSAR v primerih… Advisors/Committee Members: Fajmut, Aleš.

Subjects/Keywords: fizikalni in matematični model; farmakokinetični model; encimska kinetika; inhibicija encimov; metabolne mreže; eikozanoidi; nesteroidni antirevmatiki; gladka mišična celica dihalnih poti; bronhokonstrikcija; astma; aspirinska intoleranca; sistemska farmakologija; physical and mathematical model; pharmacokinetic model; enzyme kinetics; enzyme inhibition; metabolic pathway; eicosanoids; NSAID; airway smooth muscle cell; bronchoconstriction; asthma; aspirin intolerance; systems pharmacology; info:eu-repo/classification/udc/519.87:615(043.2)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Emeršič, T. (2015). Modelna napoved forsiranega izdihanega volumna v prvi sekundi (FEV1) pred in po zaužitju nesteroidnih antirevmatikov. (Masters Thesis). Univerza v Mariboru. Retrieved from https://dk.um.si/IzpisGradiva.php?id=54146 ; https://dk.um.si/Dokument.php?id=79295&dn= ; https://plus.si.cobiss.net/opac7/bib/21565960?lang=sl

Chicago Manual of Style (16^th Edition):

Emeršič, Tadej. “Modelna napoved forsiranega izdihanega volumna v prvi sekundi (FEV1) pred in po zaužitju nesteroidnih antirevmatikov.” 2015. Masters Thesis, Univerza v Mariboru. Accessed March 02, 2021. https://dk.um.si/IzpisGradiva.php?id=54146 ; https://dk.um.si/Dokument.php?id=79295&dn= ; https://plus.si.cobiss.net/opac7/bib/21565960?lang=sl.

MLA Handbook (7^th Edition):

Emeršič, Tadej. “Modelna napoved forsiranega izdihanega volumna v prvi sekundi (FEV1) pred in po zaužitju nesteroidnih antirevmatikov.” 2015. Web. 02 Mar 2021.

Vancouver:

Emeršič T. Modelna napoved forsiranega izdihanega volumna v prvi sekundi (FEV1) pred in po zaužitju nesteroidnih antirevmatikov. [Internet] [Masters thesis]. Univerza v Mariboru; 2015. [cited 2021 Mar 02]. Available from: https://dk.um.si/IzpisGradiva.php?id=54146 ; https://dk.um.si/Dokument.php?id=79295&dn= ; https://plus.si.cobiss.net/opac7/bib/21565960?lang=sl.

Council of Science Editors:

Emeršič T. Modelna napoved forsiranega izdihanega volumna v prvi sekundi (FEV1) pred in po zaužitju nesteroidnih antirevmatikov. [Masters Thesis]. Univerza v Mariboru; 2015. Available from: https://dk.um.si/IzpisGradiva.php?id=54146 ; https://dk.um.si/Dokument.php?id=79295&dn= ; https://plus.si.cobiss.net/opac7/bib/21565960?lang=sl

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