subject:(Bronchiolitis obliterans)

Universidade do Rio Grande do Sul

1. Fröhlich, Luiz Felipe. Avaliação da capacidade de exercício em adolescentes e adultos com bronquiolite obliterante pós-infecciosa.

Degree: 2012, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/71286

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Introdução: A capacidade de exercício tem sido pouco estudadaem pacientes combronquiolite obliterante pós-infecciosa (BOPI). Além disso, há poucos estudos avaliando indivíduos após a infância. Objetivos:… (more)

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Introdução: A capacidade de exercício tem sido pouco estudadaem pacientes combronquiolite obliterante pós-infecciosa (BOPI). Além disso, há poucos estudos avaliando indivíduos após a infância. Objetivos: Avaliar a capacidade aeróbia máxima em pacientes adolescentes e adultos com diagnóstico prévio de BOPI e identificar os mecanismos de limitação ao exercício. Métodos: Estudo transversal com recuperação retrospectiva de testes espirométricos de 4-6 anos antes dos atuais. Foram estudados 16 pacientes com BOPI (10-23 anos), acompanhados em um ambulatório de atendimento terciário. Todos os indivíduos realizaram teste de função pulmonar em repouso e teste de exercício cardiopulmonar com pesquisa de broncoespasmo induzido pelo exercício (BIE). Um grupo composto de 10 indivíduos saudáveis, pareado por sexo, idade e altura, foi usado como controle. Resultados: Quando comparados ao grupo controle, os pacientes com BOPI apresentaram pior função pulmonar em repouso, com moderada a grave obstrução ao fluxo de ar e aprisionamento aéreo. Capacidade aeróbica de pico foi significativamente menor nos pacientes ( O2 pico: 87±22 vs 110±21% previsto; p=0,01), com uma maior proporção de pacientes com capacidade aeróbica abaixo do normal [ O2 pico<84% previsto: 7/16(44%) vs 1/10(10%); p= 0,09]. A capacidade aeróbica máxima (expressa tanto em valores absolutos como em % previsto) dos pacientes foi significativamente associada com idade (r=0,59, p=0,02), índice de massa corpórea (IMC) (r=0,55, p=0,03), capacidade difusiva pulmonar (DLCO% previsto) (r=0,66, p=0,01), capacidade inspiratória (CI) / capacidade pulmonar total (CPT) (r=0,52, p=0,04) e volume residual (RV) / CPT (r=-0,56, p=0,03). Nenhuma associação foi encontrada, no entanto, entre a O2 de pico e os valores finais de exercícios e variação da oximetria de pulso (SpO2), relação ventilação de pico/ventilação voluntária máxima( E/VVM) e outros valores da função pulmonar em repouso quando expresso em % do previsto. Por outro lado, o volume expiratório forçado no 1ºs (VEF1) foi moderadamente correlacionado com DLCO (r=0,59, p=0,03) e fortemente com CI/CPT (r=0,90, p=0,00) e VR/CPT (r=-0,89, p=0,00). Valores espirométricos atuais não foram diferentes dos de 4-6 anos atrás, quando expresso em % do previsto [VEF1: 60±30 vs 60±22; capacidade vital forçada (CVF): 73±22 vs 69±14], embora, quando expresso em litros, valores atuais foram maiores (VEF1: 1,94±0,93 vs 1,14±0,50; CVF: 2,79±0,89 vs 1,52±0,45, p<0,01). Conclusão: Pacientes adolescentes e adultos com BOPI apresentaram uma capacidade aeróbia de pico reduzida em comparação comcontroles saudáveis, sendo que aproximadamente metade dos pacientes tiveram redução da capacidade aeróbica quando expresso em porcentagem do previsto. A capacidade aeróbica de pico foi diretamente relacionada com a idade, a capacidade de difusão pulmonar e os parâmetros de hiperinflação pulmonar e aprisionamento aéreo. Quanto maior a limitação do fluxo de ar (menor VEF1) maior foi a hiperinsuflação e aprisionamento aéreo.

Introduction: Repercussion in exercise…

Advisors/Committee Members: Silva, Fernando Antonio de Abreu e.

Subjects/Keywords: Bronquiolite obliterante; Bronchiolitis obliterans; Testes de função respiratória; Constrictive bronchiolitis; Exercício; Bronchiolitis; Viral; Respiratory function tests; Exercise test; Oxygen consumption

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fröhlich, L. F. (2012). Avaliação da capacidade de exercício em adolescentes e adultos com bronquiolite obliterante pós-infecciosa. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/71286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fröhlich, Luiz Felipe. “Avaliação da capacidade de exercício em adolescentes e adultos com bronquiolite obliterante pós-infecciosa.” 2012. Thesis, Universidade do Rio Grande do Sul. Accessed February 28, 2021. http://hdl.handle.net/10183/71286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fröhlich, Luiz Felipe. “Avaliação da capacidade de exercício em adolescentes e adultos com bronquiolite obliterante pós-infecciosa.” 2012. Web. 28 Feb 2021.

Vancouver:

Fröhlich LF. Avaliação da capacidade de exercício em adolescentes e adultos com bronquiolite obliterante pós-infecciosa. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2012. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10183/71286.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fröhlich LF. Avaliação da capacidade de exercício em adolescentes e adultos com bronquiolite obliterante pós-infecciosa. [Thesis]. Universidade do Rio Grande do Sul; 2012. Available from: http://hdl.handle.net/10183/71286

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Duke University

2. O'Koren, Emily Grace. Cellular and Molecular Mediators of Bronchiolitis Obliterans-like Pathological Changes in a Murine Model of Chlorine Gas Inhalation .

Degree: 2013, Duke University

URL: http://hdl.handle.net/10161/8233

► Bronchiolitis Obliterans (BO) is a major cause of chronic airway dysfunction after toxic chemical inhalation. The pathophysiology of BO is not well understood, but… (more)

▼ Bronchiolitis Obliterans (BO) is a major cause of chronic airway dysfunction after toxic chemical inhalation. The pathophysiology of BO is not well understood, but epithelial cell injury has been closely associated with the development of fibrotic lesions in human studies and in animal models of both toxin- and transplant-induced BO. However, while almost all cases and models of BO include epithelial injury, not all instances of epithelial injury result in BO, suggesting that epithelial damage per se is not the critical event leading to the development of BO. In this dissertation, we describe a model of chlorine (Cl2)-induced BO in which mice develop tracheal and large airway obliterative lesions within 10 days of exposure to high (350 ppm), but not low (200 ppm), concentrations of Cl2 gas. Lesions develop in a series of well-demarcated pathological changes that include epithelial denudation, inflammatory cell infiltration by day 2 after exposure, fibroblast infiltration and collagen deposition by day 5, and in-growth of blood vessels by day 7, ultimately leading to lethal airway obstruction by days 9-12. Using this model, we were able to test our hypothesis that loss of epithelial progenitor cells is a critical factor leading to the development of obliterative airway lesions after chemical inhalation. Indeed, these lesions arise only under conditions and in areas in which basal cells, the resident progenitor cells for large airway epithelium, are eliminated by Cl2 exposure. The molecular pathways contributing to BO development are not well understood. Mechanisms of epithelial injury differ across BO models, but we hypothesized that after the inciting injury, BO models share common pathways. We compared microarray analysis from day 5 non-BO- and BO-inducing chemical injuries and subsequently identified biological pathways that may contribute to BO pathogenesis. Our findings add support to pathways previously implicated in BO development and more importantly, suggest potential new pathways and molecular mediators of BO. Furthermore, we evaluated the efficacy of therapeutic inhibition of neovascularization or inflammation to prevent Cl2-induced BO. To date, our therapeutic interventions were ineffective. Nonetheless, our findings suggest that in the context of Cl2-induced BO, vascular endothelial growth factor receptor 2 (a mediator of neovascularization) and inducible nitric oxide synthase (a mediator of inflammation) are not critical in BO pathogenesis. In sum, our work introduces and characterizes a novel Cl2-induced murine model of BO. Using this model we demonstrated that in the absence of basal cells, epithelial regeneration does not occur and regions of epithelial denudation persist from which an aberrant repair process is initiated, leading to obliterative airway lesions. Our findings suggest that, irrespective of the cause, loss of epithelial progenitor cells may be a critical factor leading to the development of BO. Furthermore, our gene expression analysis implicates novel mediators and… Advisors/Committee Members: Gunn, Michael D (advisor), He, You Wen (advisor).

Subjects/Keywords: Immunology; Cellular biology; basal cells; bronchiolitis obliterans; chlorine; fibrosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

O'Koren, E. G. (2013). Cellular and Molecular Mediators of Bronchiolitis Obliterans-like Pathological Changes in a Murine Model of Chlorine Gas Inhalation . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/8233

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

O'Koren, Emily Grace. “Cellular and Molecular Mediators of Bronchiolitis Obliterans-like Pathological Changes in a Murine Model of Chlorine Gas Inhalation .” 2013. Thesis, Duke University. Accessed February 28, 2021. http://hdl.handle.net/10161/8233.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

O'Koren, Emily Grace. “Cellular and Molecular Mediators of Bronchiolitis Obliterans-like Pathological Changes in a Murine Model of Chlorine Gas Inhalation .” 2013. Web. 28 Feb 2021.

Vancouver:

O'Koren EG. Cellular and Molecular Mediators of Bronchiolitis Obliterans-like Pathological Changes in a Murine Model of Chlorine Gas Inhalation . [Internet] [Thesis]. Duke University; 2013. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10161/8233.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

O'Koren EG. Cellular and Molecular Mediators of Bronchiolitis Obliterans-like Pathological Changes in a Murine Model of Chlorine Gas Inhalation . [Thesis]. Duke University; 2013. Available from: http://hdl.handle.net/10161/8233

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Garippo, Ana Lúcia. Estudo morfométrico da imunidade celular e remodelamento no eixo pré-acinar na indução do colágeno tipo V em um modelo de bronquiolite obliterante.

Degree: PhD, Fisiopatologia Experimental, 2007, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5160/tde-16032007-163239/ ;

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A minoria dos pacientes em processo de remodelamento pulmonar por bronquiolite obliterante (BO) responde a corticosteróides. Nos propusemos assim, a avaliar a importância da tolerância… (more)

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A minoria dos pacientes em processo de remodelamento pulmonar por bronquiolite obliterante (BO) responde a corticosteróides. Nos propusemos assim, a avaliar a importância da tolerância gerada pela imunização via nasal pelo colágeno tipo V (ctV) como uma opção no tratamento da BO. Através da análise morfométrica, mensuramos as dimensões, a densidade de colágeno e infiltrado celular no eixo pré-acinar visando o entendimento na patogênese da BO. Aplicamos essa metodologia a três protocolos: primeiro, o estabelecimento do modelo da BO em camundongos BALB/c. Segundo, a tolerância preventiva a BO. Terceiro, comparar os tratamentos prednisona vs tolerância após a BO já estabelecida. Oito semanas após uma única instilação de HNO3-nasal, as mudanças pulmonares foram caracterizadas pela distorção do lúmen, perda da barreira epitelial, redução ou total obliteração do lúmen do bronquíolo terminal e aumento do espessamento da parede. Modelo da BO: A densidade do infiltrado celular total mostrou valores significantes quando comparados os pulmões BO vs salina e controle (P = 0,001 para ambos), com maior evidência a densidade macrófagos nos pulmões controle vs BO e salina (P = 0,01 e P = 0,04, respectivamente). Tolerância preventiva: A densidade de CD3+ mostrou diminuição significante quando comparado ao estágio intermediário da doença nos pulmões BO vs BO+ctV e controle (P = 0,001 e P = 0,002, respectivamente). Houve também diminuição estatística da densidade de células CD20+ quando comparados os pulmões BO vs ctv+BO, BO+ctV, e controle (P = 0,008, P = 0,004 e P = 0,001). Prednisona vs tolerância: A densidade total de células diminuiu drasticamente quando comparados os pulmões BO vs BO+ctV e controle (P = 0,003 e P = 0,001, respectivamente). As células CD3+ mostraram diminuição quando comparados os pulmões BO vs BO+pr, BO+ctV e controle (P = 0,03, P = 0,03 e P = 0,05, respectivamente). Houve também diminuição das células CD20+ e CD4+ quando comparados os pulmões BO vs BO+ctV e controle (P = 0, 006 e P = 0,004, respectivamente) e (P = 0,001 para ambos). A histoarquitetura e a densidade de células dos pulmões BO+ctV se assemelharam ao pulmões controle. A tolerância pelo ctV comparada com o prednisona, mostrou marcante diminuição da deposição de colágeno e infiltrado celular no eixo pré-acinar. Nossos resultados indicam que o ctV pode atuar como um supressor da resposta imune. Concluímos, portanto, que a morfometria foi um método apropriado para relatar o espectro de mudanças histológicas no modelo de BO proposto.

A minority of patients with remodeling process of lungs following bronquiolite obliterante (BO) responds to corticosteroids. So, we sought to validate the importance of type V collagen (tVc) tolerance from immunization as option in BO model treatment. Througt of morphometric analyses, we have mensured for the dimensions, the collagen and cell infiltration density on pre-acinar axis, target the understand of BO pathogenesis. We applied for tree protocols: First, the establishment of BO model on BALB/c mice. Second,…

Advisors/Committee Members: Capelozzi, Vera Luiza.

Subjects/Keywords: Bronchiolitis obliterans/chemically induced; Bronchiolitis obliterans/immunology; Bronquiolite obliterante/imunologia; Bronquiolite obliterante/induzido quimicamente; Colágeno tipo V/imunologia; Collagen type V/immunization; Collagen/immunology; Immunesuppression; Imunização; Imunosupressão

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Garippo, A. L. (2007). Estudo morfométrico da imunidade celular e remodelamento no eixo pré-acinar na indução do colágeno tipo V em um modelo de bronquiolite obliterante. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5160/tde-16032007-163239/ ;

Chicago Manual of Style (16^th Edition):

Garippo, Ana Lúcia. “Estudo morfométrico da imunidade celular e remodelamento no eixo pré-acinar na indução do colágeno tipo V em um modelo de bronquiolite obliterante.” 2007. Doctoral Dissertation, University of São Paulo. Accessed February 28, 2021. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-16032007-163239/ ;.

MLA Handbook (7^th Edition):

Garippo, Ana Lúcia. “Estudo morfométrico da imunidade celular e remodelamento no eixo pré-acinar na indução do colágeno tipo V em um modelo de bronquiolite obliterante.” 2007. Web. 28 Feb 2021.

Vancouver:

Garippo AL. Estudo morfométrico da imunidade celular e remodelamento no eixo pré-acinar na indução do colágeno tipo V em um modelo de bronquiolite obliterante. [Internet] [Doctoral dissertation]. University of São Paulo; 2007. [cited 2021 Feb 28]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5160/tde-16032007-163239/ ;.

Council of Science Editors:

Garippo AL. Estudo morfométrico da imunidade celular e remodelamento no eixo pré-acinar na indução do colágeno tipo V em um modelo de bronquiolite obliterante. [Doctoral Dissertation]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/5/5160/tde-16032007-163239/ ;

4. Teixeira, Mariangela Faria Cardoso. Avaliação da resposta funcional a curto prazo ao tiotrópio em crianças e adolescentes com brinquiolite obliterante.

Degree: Mestrado, Pediatria, 2013, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-18102013-160434/ ;

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Introdução: Os pacientes com bronquiolite obliterante (BO) costumam apresentar acometimento importante da função pulmonar que resulta em hipoxemia crônica e limitação da atividade física. Não… (more)

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Introdução: Os pacientes com bronquiolite obliterante (BO) costumam apresentar acometimento importante da função pulmonar que resulta em hipoxemia crônica e limitação da atividade física. Não há terapêutica de grande eficácia na BO, a resposta aos broncodilatadores costuma ser pobre, entretanto, não se conhece a resposta broncodilatadora a um agente anticolinérgico de longa ação como o brometo de tiotrópio (BT). Já se demonstrou eficácia e segurança do BT em adultos com doença pulmonar obstrutiva crônica (DPOC) com resposta broncodilatadora significativa e sustentada em dose única diária. Objetivo: Avaliar se existe melhora do grau de obstrução brônquica e do aprisionamento aéreo, através de medidas funcionais, após o uso de dose única de brometo de tiotrópio por via inalatória comparado a placebo em crianças e adolescentes com BO. Métodos: Ensaio clínico prospectivo, duplo cego, randomizado, placebocontrolado e cruzado em pacientes com BO estáveis na faixa etária de 6 a 16 anos. Espirometrias e pletismografias foram realizadas antes e aos 30, 60, 120, 180 minutos e 24 horas após a inalação de 18 mcg de tiotrópio ou placebo. Após 7-14 dias, os medicamentos foram invertidos e os procedimentos repetidos. As mudanças nos parâmetros de função pulmonar em cada momento foram comparadas com o basal através da análise de variância (ANOVA) e pós-teste de Tukey e as diferenças entre todos os momentos versus o basal nos grupos tiotrópio versus placebo foram comparados usando o teste de Friedman. Resultados: Trinta pacientes participaram do estudo (23 do sexo masculino, 7 do feminino; idade 10,9±2,8a ), com valores basais de função pulmonar (% do previsto) de CVF, VEF1, VEF1/CVF, FEF25-75%, CI, CPT, VR, VR/CPT, resistência das vias aéreas (raw) e condutância (sGaw) de 75±15, 48±14, 59±11, 22±11, 64±23, 120±19, 281±101, 49±13, 250±65 e 23±9, respectivamente. Diferenças estatisticamente significantes foram observadas após inalação do tiotrópio nos seguintes parâmetros comparados ao tempo basal: CVF em 60/120/180 min/24h, VEF1 em 30/60/120/180min, VEF1/CVF em 60/120/180min, FEF25- 75% em 60/120/180min, VR em 30/60/120/180min, CPT em 30/120/180min, VR/CPT em 30/60/120/180min, raw em 30/60/120/180min/24h e sGaw em 30/60/120/180min/24h. Na fase placebo não houve diferença estatisticamente significante em nenhum parâmetro funcional em nenhum momento após a administração. As diferenças entre as medidas funcionais comparando o grupo tiotrópio versus o grupo placebo foram estatisticamente significantes. Conclusões: O brometo de tiotrópio, após dose única, diminuiu agudamente o grau de obstrução e de aprisionamento aéreo por até 24 horas em crianças com BO. Estudos de longo prazo são necessários para se avaliar o papel do BT na terapêutica desses pacientes

Introduction: Patients with bronchiolitis obliterans (BO) usually have severe airflow obstruction that results in chronic hypoxemia and limitation of physical activity. There is no efficient therapy for BO, bronchodilator response is usually poor, however, the bronchodilator response…

Advisors/Committee Members: Adde, Fabiola Villac.

Subjects/Keywords: Antagonistas colinérgicos; Bronchiolitis obliterans; Bronchodilators; Broncodilatadores; Bronquiolite obliterante; Child; Cholinergic antagonists; Criança; Tiotrópio; Tiotropium

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Teixeira, M. F. C. (2013). Avaliação da resposta funcional a curto prazo ao tiotrópio em crianças e adolescentes com brinquiolite obliterante. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5141/tde-18102013-160434/ ;

Chicago Manual of Style (16^th Edition):

Teixeira, Mariangela Faria Cardoso. “Avaliação da resposta funcional a curto prazo ao tiotrópio em crianças e adolescentes com brinquiolite obliterante.” 2013. Masters Thesis, University of São Paulo. Accessed February 28, 2021. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-18102013-160434/ ;.

MLA Handbook (7^th Edition):

Teixeira, Mariangela Faria Cardoso. “Avaliação da resposta funcional a curto prazo ao tiotrópio em crianças e adolescentes com brinquiolite obliterante.” 2013. Web. 28 Feb 2021.

Vancouver:

Teixeira MFC. Avaliação da resposta funcional a curto prazo ao tiotrópio em crianças e adolescentes com brinquiolite obliterante. [Internet] [Masters thesis]. University of São Paulo; 2013. [cited 2021 Feb 28]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-18102013-160434/ ;.

Council of Science Editors:

Teixeira MFC. Avaliação da resposta funcional a curto prazo ao tiotrópio em crianças e adolescentes com brinquiolite obliterante. [Masters Thesis]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-18102013-160434/ ;

5. Tomikawa, Silvia Onoda. Evolução de pacientes pediátricos com bronquiolite obliterante submetidos à pulsoterapia com metilprednisolona endovenosa.

Degree: Mestrado, Pediatria, 2010, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-03092010-095518/ ;

► Introdução: bronquiolite obliterante (BO) é uma forma rara de doença pulmonar crônica que ocorre após uma injúria grave ao trato respiratório inferior e resulta em… (more)

▼ Introdução: bronquiolite obliterante (BO) é uma forma rara de doença pulmonar crônica que ocorre após uma injúria grave ao trato respiratório inferior e resulta em estreitamento ou obliteração total das pequenas vias aéreas. Há várias etiologias possíveis, mas em crianças a doença é geralmente pós-infecciosa. O tratamento básico é de suporte, pois não há medidas terapêuticas comprovadamente efetivas. Há evidências, baseadas em estudos animais, de que o uso de corticóides na fase inicial da doença poderia modificar seu curso, revertendo a atividade inflamatória, especialmente a deposição de fibroblastos. A pulsoterapia é utilizada para reduzir os efeitos colaterais da administração sistêmica prolongada de corticóide oral, e é uma alternativa para os pacientes com quadros mais graves. Objetivos: avaliar parâmetros clínicos, laboratoriais, radiológicos e de função pulmonar nos pacientes pediátricos com bronquiolite obliterante submetidos a pulsoterapia com metilprednisolona, antes e após o procedimento, e demonstrar que ocorre melhora clínica, considerando-se o grau de hipoxemia, número de agudizações pulmonares, função pulmonar, número de internações, uso prolongado de corticóides orais e suas complicações. Avaliar também os efeitos colaterais e complicações do tratamento. Métodos: foram avaliadas 40 crianças na faixa etária de até 18 anos, de ambos os sexos, em seguimento na Divisão de Pneumologia Pediátrica do Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, com diagnóstico de bronquiolite obliterante por dados clínicos e tomográficos e/ou de biópsia pulmonar, e que foram submetidas à pulsoterapia com metilprednisolona endovenosa pelo período mínimo de seis meses. A análise estatística foi feita usando testes não paramétricos para comparação de medidas repetidas (Friedman, Wilcoxon), e para comparação múltiplas foi realizado o pós-teste de Dunn com nível de significância = 5%. Resultados: houve diminuição no número de agudizações pulmonares comparando o período de seis meses antes da pulsoterapia e 24 meses após o início da pulsoterapia (p=0,0042). Houve diminuição no número de internações hospitalares comparando o período de seis meses antes da pulsoterapia e 18 meses após (p<0,0001). Houve melhora na saturação de oxigênio comparando o período de seis meses antes e no primeiro (p=0,0002) e segundo ano após (p=0,0005). Houve aumento na estatura e peso das crianças comparando o início e o final da xii pulsoterapia: escore Z aumentou de -1,08 para -0,63 (p=0,015) e de -0,91 para -0,59 (p=0,039) respectivamente. Dos 23 pacientes em corticoterapia oral contínua, foi possível suspensão em 20 (87%). Dos 20 pacientes em oxigenoterapia domiciliar, foi possível a suspensão completa em seis pacientes. Conclusões: a pulsoterapia com metilprednisolona pode ser eficaz no tratamento de pacientes com bronquiolite obliterante, resultando em diminuição das agudizações pulmonares e internações hospitalares, com retirada da corticoterapia oral contínua e da oxigenoterapia domiciliar… Advisors/Committee Members: Rodrigues, Joaquim Carlos.

Subjects/Keywords: Bronchiolitis obliterans; Bronquiolite obliterante/terapia; Child; Criança; Methylprednisolone; Metilprednisolona; Pulse therapy; Pulsoterapia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tomikawa, S. O. (2010). Evolução de pacientes pediátricos com bronquiolite obliterante submetidos à pulsoterapia com metilprednisolona endovenosa. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5141/tde-03092010-095518/ ;

Chicago Manual of Style (16^th Edition):

Tomikawa, Silvia Onoda. “Evolução de pacientes pediátricos com bronquiolite obliterante submetidos à pulsoterapia com metilprednisolona endovenosa.” 2010. Masters Thesis, University of São Paulo. Accessed February 28, 2021. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-03092010-095518/ ;.

MLA Handbook (7^th Edition):

Tomikawa, Silvia Onoda. “Evolução de pacientes pediátricos com bronquiolite obliterante submetidos à pulsoterapia com metilprednisolona endovenosa.” 2010. Web. 28 Feb 2021.

Vancouver:

Tomikawa SO. Evolução de pacientes pediátricos com bronquiolite obliterante submetidos à pulsoterapia com metilprednisolona endovenosa. [Internet] [Masters thesis]. University of São Paulo; 2010. [cited 2021 Feb 28]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-03092010-095518/ ;.

Council of Science Editors:

Tomikawa SO. Evolução de pacientes pediátricos com bronquiolite obliterante submetidos à pulsoterapia com metilprednisolona endovenosa. [Masters Thesis]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/5/5141/tde-03092010-095518/ ;

Universiteit Utrecht

6. Kastelijn, E.A. Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis.

Degree: 2012, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/218111

► Lung transplantation is the treatment of choice for patients with end-stage lung disease. However, long-term survival is limited due to the development of chronic rejection… (more)

▼ Lung transplantation is the treatment of choice for patients with end-stage lung disease. However, long-term survival is limited due to the development of chronic rejection in the donor lung of the transplant recipient, called bronchiolitis obliterans syndrome (BOS). BOS is diagnosed after lung transplantation when a decline in lung function occurs, which is not due to rejection, infection or problems of the bronchial anastomosis. The development of BOS is characterized by persistent injury of the airway epithelium that is caused by several factors. This process leads to inflammation and remodeling, which is followed by an aberrant repair response, and finally fibrosis and occlusion of the small airways of the allograft. When BOS is diagnosed, the process is already at an advanced and mostly irreversible stage and treatment options are limited. The current status of diagnosis of BOS clearly indicates the need for biomarkers in serum and DNA that may detect processes leading to BOS before the decline in lung function occurs. These unmet needs are the basis of this thesis. TLRs are critical molecules for activation of the innate immune system by recognition of pathogens, and they can prevent the induction of allograft tolerance. Genetic polymorphisms in Toll-like receptor (TLR)2, TLR4 and TLR9 might contribute to patients’ susceptibility for BOS. These genetic polymorphisms could predispose to increased secretion of pro-inflammatory cytokines, causing injury and inflammation of the airway epithelium. The exact role of different types of cytokines in rejection or tolerance of the allograft is under debate. We showed that the T helper (Th)1 cytokines were similar between patients who developed BOS (BOSpos)and those who did not (BOSneg)patients. However, the Th2 cytokines revealed a different pattern between these two groups. This suggests that Th2 cytokines are involved in the process of chronic rejection, possibly due to the inhibition of transplant tolerance, the absence of inhibition of the Th1 response and the influence on proliferation of regulatory T-cells. In relation to excessive injury and chronic inflammation, the process of fibrogenesis is considered to be of central importance to the development of BOS. Normally, after injury of the airway epithelium an adequate repair mechanism is required to prevent fibrogenesis. BOSpos patients, however, seem to have an impaired repair mechanism and a profibrotic airway milieu. They had a different genotype distribution of matrix metalloproteinase (MMP)7 and lower levels of MMP-7 than BOSneg patients which might contribute to an impaired repair mechanism of the airway epithelium. Besides, there is more degradation and turnover of the extracellular matrix in BOSpos patients than in BOSneg patients as shown by increased levels of MMP-9. Though, the functionality of the genetic polymorphisms in the caveolin-1 (CAV1) gene is not known, it might contribute to fibrogenesis as well through the transforming growth factor beta signaling pathway. In… Advisors/Committee Members: Grutters, J.C., Lammers, J.W.J., Ruven, H.J.T., Moorsel, C.H.M. van.

Subjects/Keywords: Geneeskunde; Geneeskunde; lung transplantation; bronchiolitis obliterans syndrome; chronic rejection; biomarkers; genetic polymorphism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kastelijn, E. A. (2012). Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/218111

Chicago Manual of Style (16^th Edition):

Kastelijn, E A. “Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis.” 2012. Doctoral Dissertation, Universiteit Utrecht. Accessed February 28, 2021. http://dspace.library.uu.nl:8080/handle/1874/218111.

MLA Handbook (7^th Edition):

Kastelijn, E A. “Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis.” 2012. Web. 28 Feb 2021.

Vancouver:

Kastelijn EA. Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2012. [cited 2021 Feb 28]. Available from: http://dspace.library.uu.nl:8080/handle/1874/218111.

Council of Science Editors:

Kastelijn EA. Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis. [Doctoral Dissertation]. Universiteit Utrecht; 2012. Available from: http://dspace.library.uu.nl:8080/handle/1874/218111

7. Ericson, Petrea. Potential biomarkers for acute and chronic rejection after lung transplantation.

Degree: 2016, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/44856

► Abstract Chronic rejection in the form of bronchiolitis obliterans syndrome (BOS) is the main hindrance for long-term survival after lung transplantation. Repeated acute rejections (AR)… (more)

▼ Abstract Chronic rejection in the form of bronchiolitis obliterans syndrome (BOS) is the main hindrance for long-term survival after lung transplantation. Repeated acute rejections (AR) constitute a major risk factor for developing BOS. The aim of this thesis was to expand the knowledge of the biological processes underlying AR and BOS and to identify potential immunological biomarkers for these conditions. The following specific research questions were posed: Are alterations in IL-18 concentration associated with AR (paper I)? Are there local pulmonary changes in the protease/anti-protease balance in BOS (paper II)? Is the neutrophil mobilizing cytokine IL-26 involved in AR and BOS development (paper III)? Does composition of particles in exhaled air (PEx) differ between BOS/non-BOS (paper IV)? Methods: In a biobank of collected bronchoalveolar lavage (BAL) samples from lung transplant recipients (LTRs), we identified patients, with or without AR and BOS respectively, who were carefully matched. The matching procedure included preoperative diagnosis, age, gender, type of and time after transplantation to avoid the influence of confounding clinical factors. Inflammatory cells and soluble mediators involved in the inflammatory process were analyzed in BAL samples (paper I-III). In paper IV, PEx composition in LTRs and healthy controls was investigated with a novel method that enables non-invasive sampling from the distal airways. Results: There were no changes in IL-18 concentration or correlation between IL-18 and lymphocyte percentages in BAL samples from patients with AR (paper I). Increased net gelatinase activity and a clear correlation between activity and concentration of the gelatinase MMP-9 (but not MMP-2) as well as a correlation between activity and neutrophil percentages were found in BAL samples from BOS patients (paper II). It was also found that the concentration of IL-26 in BAL samples from patients with BOS (but not AR) was increased and intracellular IL-26 was detected in alveolar macrophages and lymphocytes (paper III). Finally, surfactant protein A (SP-A) was lower in PEx from BOS patients compared to stable LTRs and LTRs, in particular BOS patients, exhaled a higher amount of PEx than healthy controls (paper IV). Conclusions: These findings forward evidence that local unopposed gelatinase activity, likely to be accounted for by the gelatinase MMP-9 from neutrophils, and the neutrophil mobilizing cytokine IL-26 from macrophages and lymphocytes, are involved in BOS development. The results also show that PEx composition differs between stable LTRs and patients that develop BOS. The clinical utility of PEx as a non-invasive diagnostic tool in the follow up after lung transplantation and the possibility of targeting MMP-9 and IL-26 for early detection, monitoring and possibly even treatment of BOS warrant further study. Key words: lung transplantation, graft rejection, bronchiolitis obliterans syndrome, IL-18, MMP-9, IL-26, surfactant protein

Subjects/Keywords: lung transplantation; graft rejection; bronchiolitis obliterans syndrome; IL-18; MMP-9; IL-26; surfactant protein

11 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ericson, P. (2016). Potential biomarkers for acute and chronic rejection after lung transplantation. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/44856

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ericson, Petrea. “Potential biomarkers for acute and chronic rejection after lung transplantation.” 2016. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 28, 2021. http://hdl.handle.net/2077/44856.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ericson, Petrea. “Potential biomarkers for acute and chronic rejection after lung transplantation.” 2016. Web. 28 Feb 2021.

Vancouver:

Ericson P. Potential biomarkers for acute and chronic rejection after lung transplantation. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2077/44856.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ericson P. Potential biomarkers for acute and chronic rejection after lung transplantation. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2016. Available from: http://hdl.handle.net/2077/44856

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

8. Johansson, Inger. Cytomegalovirus Infection in Heart and Lung Transplant Patients with focus on long-term outcome.

Degree: 2014, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/35459

► Cytomegalovirus (CMV) infection is a common opportunistic infection after heart and lung transplantation. The aims of this thesis were to relate the incidence and severity… (more)

▼ Cytomegalovirus (CMV) infection is a common opportunistic infection after heart and lung transplantation. The aims of this thesis were to relate the incidence and severity of CMV infection and disease to different forms of antiviral prevention and to evaluate whether CMV is a risk factor for bronchiolitis obliterans syndrome (BOS) after lung transplantation and coronary artery vasculopathy (CAV) after heart transplantation. CMV disease had a significant negative impact on 10-year survival as compared with no CMV infection in a study of 187 lung transplant patients. CMV prevention with 14 weeks of oral ganciclovir reduced the incidence and severity and prolonged the time to onset of CMV disease, as compared with four weeks of intravenous ganciclovir in CMV seropositive patients. Our finding supports the hypothesis that a longer duration of CMV prophylaxis is beneficial to lung transplant patients (Paper I). BOS-free 4-year survival was significantly reduced with CMV disease as compared with no CMV infection. A lower incidence of CMV infection/disease and acute cellular rejection was observed with valganciclovir (3 months) when compared with oral ganciclovir (3 months), in CMV seropositive lung transplant patients. We concluded that CMV disease reduces BOS-free survival and that CMV prevention with valganciclovir is superior compared with oral ganciclovir in lung transplant patients (Paper II). Survival and CAV-free survival were significantly reduced in heart transplant patients with CMV disease and asymptomatic CMV infection compared with no CMV infection after a 10-year follow-up in a study of 226 patients. Our study supports the use of an aggressive strategy for reducing not only CMV disease but also asymptomatic infection after heart transplantation (Paper III). Low-dose valganciclovir prophylaxis (450 mg daily) for 3 months to CMV seropositive heart transplant recipients prevented CMV disease and significantly reduced the number of patients with reactivated asymptomatic CMV infection when compared with a pre-emptive approach. We found that low-dose valganciclovir is safe and effective, but this has to be confirmed in prospective studies (Paper IV).

Subjects/Keywords: heart transplantation; lung transplantation; cytomegalovirus; cardiac allograft vasculopathy; ganciclovir; valganciclovir; bronchiolitis obliterans syndrome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Johansson, I. (2014). Cytomegalovirus Infection in Heart and Lung Transplant Patients with focus on long-term outcome. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/35459

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Johansson, Inger. “Cytomegalovirus Infection in Heart and Lung Transplant Patients with focus on long-term outcome.” 2014. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 28, 2021. http://hdl.handle.net/2077/35459.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Johansson, Inger. “Cytomegalovirus Infection in Heart and Lung Transplant Patients with focus on long-term outcome.” 2014. Web. 28 Feb 2021.

Vancouver:

Johansson I. Cytomegalovirus Infection in Heart and Lung Transplant Patients with focus on long-term outcome. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2077/35459.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Johansson I. Cytomegalovirus Infection in Heart and Lung Transplant Patients with focus on long-term outcome. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2014. Available from: http://hdl.handle.net/2077/35459

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

9. Mattiello, Rita. Avaliação cardiorrespiratória em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.

Degree: 2008, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/12637

►

Objetivo: Avaliar o condicionamento cardiorrespiratório de crianças e adolescentes com BOPI através do teste cardiopulmonar de exercício (TCPE). Métodos: Foram estudadas 20 crianças com BOPI,… (more)

▼

Objetivo: Avaliar o condicionamento cardiorrespiratório de crianças e adolescentes com BOPI através do teste cardiopulmonar de exercício (TCPE). Métodos: Foram estudadas 20 crianças com BOPI, com idade de 8 a 16 anos, que estavam em acompanhamento ambulatorial. Os pacientes realizaram TCPE máximo em esteira, teste de caminhada de seis minutos (TC6), espirometria e pletismografia, seguindo as diretrizes ATS/ACCP, ATS e ATS/ERS, respectivamente. Para o cálculo dos percentuais esperados, foram utilizados: Armstrong (TCPE); Geiger (TC6); Kundson (espirometria), Zapletal (pletismografia). Resultados: A idade média foi de 11,4 ± 2,2 anos; 70 % meninos; peso: 36,8 ± 12,3 Kg; altura: 143,8 ± 15,2 cm; IMC: 17,6 ± 3,0. Na espirometria, os pacientes apresentavam os fluxos forçados diminuídos e, na pletismografia, os volumes estavam aumentados, quando comparados com a população de referência. No TCPE, 11 pacientes apresentaram valores do VO2 de pico inferiores (77,5 ± 37,5%) a 80% do percentual do predito e o VO 2LV foi considerado normal (40%VO2). A relação VE/VVM aumentada foi observada em 68% pacientes. A média da distância total percorrida foi de 512 ± 102 m (77,0 ± 15,7%). O VO2 de pico não se correlacionou com distância (TC6); no entanto, correlacionou-se com a CVF (L) (r=0,90/p=0,00), o VEF1 (L) (r=0,86/ p=0,00) e a VR/CPT (r=-0,71/ p=0,02) e, em percentual do predito, com a VR/CPT (-0,63/ p=0,00). Conclusões: O presente estudo demonstra que os pacientes com BOPI apresentam valores do consumo de oxigênio inferiores ao da população hígida e a reserva ventilatória diminuída, sugerindo que o comprometimento pulmonar pode ser um dos fatores limitantes para o exercício.

Objective: To assess the physical conditioning of children and adolescents with Post Infectious Bronchiolitis Obliterans (PIBO) through cardiopulmonary exercise testing (CPET). Methods: 20 children with PIBO, in follow-up at an outpatient clinic carried out CPET, six minute walking test (6MWT) and pulmonary function tests (PFT), following ATS/ACCP e ATS guidelines, respectively. Results were expressed as percentage of predicted reference values: Armstrong’s for CPET, Geiger’s for 6MWT, Knudson’s for spirometry, and Zapletal’s for plethysmography.Results: Means ± SD were: for age, 11,4 ± 2,2 years; weight: 36,8 ± 12,3 kg; height: 143,8 ± 15,2 cm; BMI: 17,6 ± 3,0. Gender: 70% boys. When compared to reference values, PFT had lower forced flows (spirometry) and increased volumes (plethysmography). CPET had 11 patients with reduced VO2peak values (< 80% predicted) and had normal VO2LV (VO2peak40%). An increased VE/MVV ratio was observed in 68% of patients. The mean distance (6MWT) was 77,0 ± 15,7% of predicted (512 ± 102 m). VO2peak did not correlate with 6MWT; however, it did correlate with FVC(L) (r=0,90/p=0,00), with FEV1(L) (r=0,86/p=0,00) and with RV/TLC (r=-0,71/p=0,02). When in percentage of predicted, with RV/TLC (r=-0,63/ p=0,00). Conclusions: This study shows that PIOB patients have lower oxygen consumption values when compared to the reference…

Advisors/Committee Members: Fischer, Gilberto Bueno, Menna Barreto, Sérgio Saldanha.

Subjects/Keywords: Bronchiolitis obliterans; Bronquiolite obliterante; Criança; Children; Adolescente; Cardiopulmonary exercise testing; Aptidão física; Testes de função respiratória; Exercício

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mattiello, R. (2008). Avaliação cardiorrespiratória em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/12637

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mattiello, Rita. “Avaliação cardiorrespiratória em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.” 2008. Thesis, Universidade do Rio Grande do Sul. Accessed February 28, 2021. http://hdl.handle.net/10183/12637.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mattiello, Rita. “Avaliação cardiorrespiratória em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.” 2008. Web. 28 Feb 2021.

Vancouver:

Mattiello R. Avaliação cardiorrespiratória em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2008. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10183/12637.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mattiello R. Avaliação cardiorrespiratória em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. [Thesis]. Universidade do Rio Grande do Sul; 2008. Available from: http://hdl.handle.net/10183/12637

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

10. Paludo, Juliana. Calorimetria indireta em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.

Degree: 2010, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/26128

►

Objetivos: Quantificar o gasto energético de crianças e adolescentes com bronquiolite obliterante pós-infecciosa acompanhados em ambulatório de pneumologia pediátrica e comparar com crianças e adolescentes… (more)

▼

Objetivos: Quantificar o gasto energético de crianças e adolescentes com bronquiolite obliterante pós-infecciosa acompanhados em ambulatório de pneumologia pediátrica e comparar com crianças e adolescentes hígidos. Metodologia: Estudo transversal com grupo controle incluindo 72 crianças e adolescentes de 8 a 18 anos. Comparou-se dois grupos de 36 indivíduos, um com diagnóstico de BO e outro hígido, os quais foram pareados pelo gênero, idade e classificação do IMC. Para avaliação nutricional utilizou-se a antropometria e a composição corporal. O gasto energético foi medido pela calorimetria indireta; o fator atividade pelo recordatório 24h de atividades físicas e a ingestão energética pelos inquéritos alimentares. Resultados: Os resultados a seguir são apresentados, respectivamente, para o grupo BO e para o grupo controle: idade (11,8 ± 2,7) e (12,3 ± 2,8); índice de massa corporal (18,9 ± 4,0 Kg/m2) e (18,8 ± 3,4 Kg/m2); gasto energético de repouso (GER) (1717,6 ± 781,5) e (2019,9 ± 819); gasto energético total (GET) (2677,5 ± 1514,0 Kcal/dia) e (3396,1 ± 1557,9Kcal/dia); estimativa da ingestão energética (2294,1 ± 746,7Kcal/dia) e (2116,5 ± 612,1Kcal/dia). O GER e GET não foram estatisticamente diferentes entre os grupos (p= 0,102; p=0,051). O GER não foi estatisticamente diferente nem quando ajustado para massa magra (p=0,116). O GER está associado a MM (r=0,490; p0,001), sendo que quanto maior a MM, maior o gasto energético. Não houve diferenças estatisticamente significativas entre o GET e o consumo energético no grupo BO (p=0,202). O grupo controle consumiu, em média, 1.279,6Kcal a menos do que o previsto pelo GET (p<0,001). Houve diferença estatisticamente significante entre o gasto energético medido pela calorimetria indireta e o estimado pelas fórmulas de predição. Todas as fórmulas de predição subestimaram a necessidade energética. Conclusão: O GER e o GET foram semelhantes entre os grupos. A estimativa da ingestão energética das crianças e adolescentes hígidos foi menor que o GET. Os resultados sugerem que todas as fórmulas de predição utilizadas subestimaram as necessidades energéticas quando comparadas com a calorimetria indireta.

Objectives: To quantify energy expenditure in children and adolescents with post-infectious obliterans bronchiolitis (OB) receiving outpatient pediatric pulmonology care and compare them with healthy children and adolescents. Methods: Cross-sectional study with control group including 72 children and adolescents aged 8-18 years. Two groups of 36 individuals were compared – one diagnosed with OB and another healthy – which were paired as to gender, age, and body mass index classification. Anthropometry and body composition were used for nutritional assessment. Energy expenditure was measured by indirect calorimetry, activity factor was assessed through 24-hour recall, and energy intake was measured by nutrition surveys. Results: The following results are respectively presented to the OB group and to the control group: age (11.8 ± 2.7) and (12.3 ± 2.8); body mass index (18.9…

Advisors/Committee Members: Fischer, Gilberto Bueno.

Subjects/Keywords: Bronquiolite obliterante; Children; Adolescents; Calorimetria indireta; Obliterans bronchiolitis; Criança; Energy metabolism; Adolescente; Indirect calorimetry; Metabolismo energetico

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Paludo, J. (2010). Calorimetria indireta em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/26128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Paludo, Juliana. “Calorimetria indireta em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.” 2010. Thesis, Universidade do Rio Grande do Sul. Accessed February 28, 2021. http://hdl.handle.net/10183/26128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Paludo, Juliana. “Calorimetria indireta em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.” 2010. Web. 28 Feb 2021.

Vancouver:

Paludo J. Calorimetria indireta em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2010. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10183/26128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Paludo J. Calorimetria indireta em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. [Thesis]. Universidade do Rio Grande do Sul; 2010. Available from: http://hdl.handle.net/10183/26128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

11. Mangili, André Rampinelli. Estudo radiológico comparativo e pulmonar funcional em crianças e adolescentes com diagnóstico de bronquiolite obliterante pós-infecciosa.

Degree: 2007, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/15916

► A bronquiolite obliterante pós-infecciosa é considerada uma complicação rara da bronquiolite viral aguda, ocorrendo em aproximadamente 1% dos casos. No entanto, observa-se que em países… (more)

▼ A bronquiolite obliterante pós-infecciosa é considerada uma complicação rara da bronquiolite viral aguda, ocorrendo em aproximadamente 1% dos casos. No entanto, observa-se que em países situados no hemisfério sul essa doença vem ocorrendo com maior freqüência. É uma doença que se caracteriza por obstrução fixa e irreversível do fluxo aéreo, como conseqüência de lesão irreversível dos bronquíolos, com formação de áreas de fibrose e preenchimento da luz bronquiolar por tecido fibroso e ocorre com maior freqüência no sexo masculino. Este estudo compreendeu um grupo de 25 pacientes já estudados por Zhang et al. com diagnóstico de bronquiolite obliterante pós-infecciosa, com o objetivo de realizar exames de imagem e compará-los com aqueles obtidos na época do primeiro estudo, a fim de identificar a evolução da doença, em termos de imagem, no período de tempo entre os dois estudos. Também foram realizados testes de função pulmonar. O estudo compreendeu um total de 21 pacientes do sexo masculino e 4 do sexo feminino. Para a comparação, foi criado um escore, o qual foi utilizado nos exames de imagem do estudo contemporâneo e também nos exames de imagem do primeiro estudo, onde maiores pontuações identificariam maior grau de lesão pulmonar. Foram obtidos exames de Tomografia Computadorizada de Alta Resolução (TCAR), cintilografia pulmonar perfusional e radiografias de tórax de todos os pacientes do estudo. As variáveis estudadas na TCAR foram espessamento de paredes brônquicas, bronquiectasias, atelectasias, áreas de hipo e hiperatenuação de parênquima pulmonar, padrão de granularidade, espessamento de septos conjuntivos e consolidação As variáveis estudadas ao radiograma convencional de tórax foram espessamento de paredes brônquicas, bronquiectasis, atelectasias, consolidação, rarefação de vasculatura pulmonar, retificação de cúpulas diafragmáticas, deformidade de caixa torácica e aumento de espaço retroesternal. Na cintilografia pulmonar perfusional foram avaliados o grau de déficit pulmonar perfusional nesse grupo de pacientes. Ao compararmos 22 exames de TCAR dos dois períodos de tempo, observamos que através da aplicação do escore, 17 (77,2%) pacientes reduziram seus valores no escore do estudo contemporâneo quando comparado ao escore do estudo anterior, 2 (9%) permaneceram com os mesmos valores e 3 (13,6%) apresentaram piora no valor dos escores. Ao compararmos exames de radiogramas de tórax de 25 pacientes, nos dois períodos de tempo, observamos que 14 (56%) apresentaram no estudo contemporâneo um aumento nos valores do escore, 8 (32%) reduziram o valor do escore e 3 (12%) permaneceram com os mesmos valores nos dois períodos de tempo. Ao compararmos os exames de cintilografia perfusional dos 25 pacientes, observamos que houve grande variabilidade nas lesões, tendo estas desaparecido em 5 (20%) pacientes, permanecido em 19 (76%) e com ausência em ambos os estudos em apenas 1 (4%) paciente. Nas provas de função pulmonar a alteração mais freqüentemente observada foi o distúrbio ventilatório obstrutivo, com variáveis… Advisors/Committee Members: Silva, Fernando Antonio de Abreu e, Irion, Klaus Loureiro.

Subjects/Keywords: Postinfectious bronchiolitis obliterans; Bronquiolite obliterante; Radiografia; High resolution computed tomography; Criança; Pulmonary perfusion scan; Adolescente; Cintilografia; Tomografia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mangili, A. R. (2007). Estudo radiológico comparativo e pulmonar funcional em crianças e adolescentes com diagnóstico de bronquiolite obliterante pós-infecciosa. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/15916

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mangili, André Rampinelli. “Estudo radiológico comparativo e pulmonar funcional em crianças e adolescentes com diagnóstico de bronquiolite obliterante pós-infecciosa.” 2007. Thesis, Universidade do Rio Grande do Sul. Accessed February 28, 2021. http://hdl.handle.net/10183/15916.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mangili, André Rampinelli. “Estudo radiológico comparativo e pulmonar funcional em crianças e adolescentes com diagnóstico de bronquiolite obliterante pós-infecciosa.” 2007. Web. 28 Feb 2021.

Vancouver:

Mangili AR. Estudo radiológico comparativo e pulmonar funcional em crianças e adolescentes com diagnóstico de bronquiolite obliterante pós-infecciosa. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2007. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10183/15916.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mangili AR. Estudo radiológico comparativo e pulmonar funcional em crianças e adolescentes com diagnóstico de bronquiolite obliterante pós-infecciosa. [Thesis]. Universidade do Rio Grande do Sul; 2007. Available from: http://hdl.handle.net/10183/15916

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

12. Furlan, Silvana Piazza. Qualidade de vida em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.

Degree: 2007, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/14048

►

Objetivo: Avaliar a qualidade de vida (QV) nos pacientes com bronquiolite obliterante pós-infecciosa (BOPI) comparando os escores de qualidade de vida com os de crianças… (more)

▼

Objetivo: Avaliar a qualidade de vida (QV) nos pacientes com bronquiolite obliterante pós-infecciosa (BOPI) comparando os escores de qualidade de vida com os de crianças hígidas. Verificar as associações entre os escores de qualidade de vida e os dados de função pulmonar de crianças com BOPI. Descrever as características sociodemográficas e clínicas das crianças envolvidas no estudo. Avaliar as propriedades psicométricas do questionário através da confiabilidade e validade. Metodologia: Após o cumprimento das exigências éticas, os dados sobre qualidade de vida foram obtidos através do questionário genérico Pediatric Quality of Life (PedsQL) 4.0. Aplicou-se o questionário em duas ocasiões, em 31 crianças com BOPI e em 80 crianças hígidas, de 8-17 anos, de ambos os sexos. Os dados foram submetidos ao teste t de Student e correlação linear de Pearson. As propriedades psicométricas do questionário foram avaliadas pela diferença mínima importante, pelo α de Cronbach e Correlação Intraclasse. Resultados: A idade média das crianças com BOPI foi de 11,2 ± 2,6 anos, 67,7% meninos, a média de anos de estudos foi 4,3 ± 2,2, apresentavam-se eutróficas 77,4% e a média do VEF1 na espirometria foi de 45%. Com relação a qualidade de vida houve diferença na média total dos escores e nos respectivos domínios entre os grupos, mas não foram diferenças estatisticamente significativas. Quanto as propriedades psicométricas do questionário, o α de Cronbach foi ≥ 0,7 no escore total e nos domínios físico, psicossocial e social nas crianças com BOPI e apenas no psicossocial nas crianças hígidas. A reprodutibilidade do questionário foi ≥ 0,7 no global e em todos os domínios, para ambos os grupos. Conclusões: Não houve diferenças na QV das crianças com BOPI em relação às hígidas. Na sua condição de questionário genérico, o PedsQL4.0 demonstrou-se confiável e, portanto, utilizável como elemento complementar no acompanhamento da saúde dessas crianças.

Objective: It aims at evaluating the quality of life in patients with postinfectious bronchiolitis obliterans (PBO) comparing their quality of life scores to the ones of healthy children. Also, at verifying the associations between the quality of life scores and the lung functioning data of PBO children. It also has the objective of describing the socio-demographic and clinical characteristics of children who were involved in the study. It aims at evaluating the psychometrical properties of the questionnaire by its reliability and validity. Methodology: After the accomplishment of ethical demands, the data about quality of life were obtained by means of the Pediatric Quality of Life (PedsQL) 4.0 generic questionnaire. It was applied in two occasions, to 31 PBO children and 80 healthy ones, between 8 and 17 years of age, of both genders. The data were submitted to the Student’s t-test and Pearson’s linear correlation. The psychometric properties of the questionnaire were assessed by the minimum important difference, by Cronbach’s α and the intraclass correlation. Results: The average age of PBO…

Advisors/Committee Members: Fischer, Gilberto Bueno.

Subjects/Keywords: Bronquiolite obliterante; Postinfectious bronchiolitis obliterans; Chronic pneumopathy; Complicações; Children; Criança; Life quality; Adolescente; PedsQL; Qualidade de vida; Estudos de validação; Questionários

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Furlan, S. P. (2007). Qualidade de vida em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/14048

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Furlan, Silvana Piazza. “Qualidade de vida em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.” 2007. Thesis, Universidade do Rio Grande do Sul. Accessed February 28, 2021. http://hdl.handle.net/10183/14048.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Furlan, Silvana Piazza. “Qualidade de vida em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.” 2007. Web. 28 Feb 2021.

Vancouver:

Furlan SP. Qualidade de vida em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2007. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10183/14048.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Furlan SP. Qualidade de vida em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. [Thesis]. Universidade do Rio Grande do Sul; 2007. Available from: http://hdl.handle.net/10183/14048

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

13. Viecili, Raqueli Biscayno. Evolução da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.

Degree: 2015, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/143087

►

Introdução: A Bronquiolite Obliterante Pós-infecciosa (BOPI) é uma síndrome clínica rara e grave caracterizada por sinais e sintomas persistentes de obstrução crônica das pequenas vias… (more)

▼

Introdução: A Bronquiolite Obliterante Pós-infecciosa (BOPI) é uma síndrome clínica rara e grave caracterizada por sinais e sintomas persistentes de obstrução crônica das pequenas vias aéreas. Objetivos: o objetivo do presente estudo é avaliar a evolução da função pulmonar de uma coorte de acompanhamento de pacientes com BOPI de Porto Alegre, Brasil. Métodos: Foram incluídas crianças, adolescentes com BOPI, de ambos os sexos, em acompanhamento de longo prazo nos ambulatórios de pneumologia pediátrica dos hospitais da Criança Santo Antônio e Materno-Infantil Presidente Vargas, ambos de Porto Alegre, Brasil. Resultados: Quanto à análise das variáveis da função pulmonar, as médias globais dos pontos analisados no tempo para cada variável foram: da CVF foi de 68,8% ± 17,7, do VEF1 foi 48% ± 15, do VEF1/CVF foi 66% ± 17, e do FEF25-75 foi 25,4% ± 14. Longitudinalmente, encontramos que houve melhora estatística e clínica, significativa, da CVF (p=0,04). Já as variáveis VEF1 e o FEF25-75, que refletem melhor o componente obstrutivo, não apresentaram mudanças significativas tanto estatisticamente (p=0,708 e p=0,873 respectivamente) quanto clinicamente, mantendo valores similares no percentual do predito ao longo do tempo. A relação VEF1/CVF sofreu uma mudança estatisticamente significativa (p=0,015), clinicamente explicável pela maior melhora da CVF comparado com o VEF1. Conclusões: Em conclusão, os resultados do nosso estudo sugerem que, em crianças e adolescentes com bronquiolite obliterante pós-infecciosa, o componente obstrutivo da função pulmonar (VEF1 e FEF25-75) sofre poucas modificações significativas, deletérias ou benéficas, ao longo do tempo. A capacidade vital forçada, por outro lado, sofre um aumento progressivo ao longo do tempo que pode ser de grande importância como fator de proteção quando iniciar o declínio fisiológico da função pulmonar na idade adulta.

Introduction: The Post-Infectious Bronchiolitis Obliterans (PIBO) is a rare and serious clinical syndrome characterized by persistent signs and symptoms of small airways’ chronic obstruction. Objectives: The objetive of this study is evaliate the evoluction of pulmonary function in a monitoring cohort of patients with PIBO from Porto Alegre, Brazil. Methods: Children, adolescents with PIBO, of both sexes were included, in long-term monitoring in pediatric pneumology clinics of Santo Antônio children’s hospital and Presidente Vargas maternal and child hospital, both from Porto Alegre, Brazil. Results: Regarding the analysis of the variables of pulmonar function, the global average of ten points analyzed in the time for each variable were: from CVF was 68,8% ± 17,7, from VEF1 was 48% ± 15, from VEF1/CVF was 66% ± 17 and from FEF25-75 was 25,4% ± 14. Lengthwise, we found that there was an statistical and clinical improvement, significant, from CVF (p=0,04). However, the variables VEF1 and the FEF25-75, which better reflect the osbstructive component, don’t show significant changes as statistically (p=0,708 and p=0,873 respectively) as clinically, keeping…

Advisors/Committee Members: Fischer, Gilberto Bueno.

Subjects/Keywords: Bronquiolite obliterante; Post-infectious bronchiolitis obliterans; Tomografia computadorizada por raios X; Pulmonary function test; Pediatria; Computed tomography of high resolution

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Viecili, R. B. (2015). Evolução da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/143087

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Viecili, Raqueli Biscayno. “Evolução da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.” 2015. Thesis, Universidade do Rio Grande do Sul. Accessed February 28, 2021. http://hdl.handle.net/10183/143087.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Viecili, Raqueli Biscayno. “Evolução da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.” 2015. Web. 28 Feb 2021.

Vancouver:

Viecili RB. Evolução da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10183/143087.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Viecili RB. Evolução da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. [Thesis]. Universidade do Rio Grande do Sul; 2015. Available from: http://hdl.handle.net/10183/143087

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Gothenburg / Göteborgs Universitet

14. Hammarström, Helena. Invasive fungal disease in immunocompromised hosts with focus on diagnostics.

Degree: 2019, University of Gothenburg / Göteborgs Universitet

URL: http://hdl.handle.net/2077/58501

► Invasive fungal diseases (IFDs) are severe conditions affecting immunocompromised patients. The primary aim of this thesis was to explore different methods for diagnosis of IFD… (more)

▼ Invasive fungal diseases (IFDs) are severe conditions affecting immunocompromised patients. The primary aim of this thesis was to explore different methods for diagnosis of IFD in different groups of immunocompromised patients. Papers I and II included patients with hematologic disorders. Paper I was a retrospective study evaluating two years of serial 1,3-β-d-glucan (betaglucan) testing. Paper II was a prospective study where samples were collected for the analysis of betaglucan, galactomannan, bm-gliotoxin (serum) and D-arabinitol/L-arabinitol (urine). The sensitivity of betaglucan and galactomannan was low early in the time course of IFD. The highest positive predictive value of betaglucan was obtained when using a cut-off level of at least 160 pg/ml and when testing patients upon clinical suspicion of IFD. Admission to ICU, previous administration of blood products and high serum triglyceride levels were associated with elevated betaglucan levels in patients without IFD. Betaglucan levels >800 pg/ml were highly indicative of IFD. Bm-gliotoxin could not be detected in patients with invasive aspergillosis. Paper III was a retrospective case-control study where frozen serum samples from HIV-infected patients and negative controls were analyzed for betaglucan and Pneumocystis PCR. Pneumocystis PCR in serum had a very high sensitivity and negative predictive value for the diagnosis of PCP. Paper IV was a prospective nationwide study on lung transplant recipients where serum and BAL-fluid samples were collected during the first post-transplant year for the analysis of betaglucan. Development of bronchiolitis obliterans syndrome (BOS) was assessed during a median 4.6 years of follow-up. Fungal colonization or tracheobronchitis had no impact on the development of BOS or on all-cause mortality. Betaglucan levels in serum were low while betaglucan levels in BAL fluid were elevated in patients with fungal tracheobronchitis. To conclude, betaglucan and Pneumocystis PCR in serum are useful diagnostic methods for different types of IFD although various issues need to be considered in order to determine their clinical applicability.

Subjects/Keywords: invasive fungal disease; diagnosis; 1,3-β-d-glucan; hematological malignancies; hematopoietic stem cell transplantation; HIV; lung transplant recipients; bronchiolitis obliterans syndrome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hammarström, H. (2019). Invasive fungal disease in immunocompromised hosts with focus on diagnostics. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/58501

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hammarström, Helena. “Invasive fungal disease in immunocompromised hosts with focus on diagnostics.” 2019. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed February 28, 2021. http://hdl.handle.net/2077/58501.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hammarström, Helena. “Invasive fungal disease in immunocompromised hosts with focus on diagnostics.” 2019. Web. 28 Feb 2021.

Vancouver:

Hammarström H. Invasive fungal disease in immunocompromised hosts with focus on diagnostics. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2019. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2077/58501.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hammarström H. Invasive fungal disease in immunocompromised hosts with focus on diagnostics. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2019. Available from: http://hdl.handle.net/2077/58501

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

15. Bosa, Vera Lúcia. Avaliação nutricional de crianças e adolescentes portadores de bronquiolite obliterante pós-infecciosa.

Degree: 2008, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/13565

► A Bronquiolite Obliterante pós-infecciosa (BO) é conseqüência de agressão ao epitélio do trato respiratório inferior que se caracteriza por obstrução da via aérea distal. Autores… (more)

▼ A Bronquiolite Obliterante pós-infecciosa (BO) é conseqüência de agressão ao epitélio do trato respiratório inferior que se caracteriza por obstrução da via aérea distal. Autores ressaltam que além do diagnóstico oportuno da BO, do tratamento agressivo das infecções e da oxigenoterapia, é importante um plano nutricional adequado para evolução clínica favorável desta enfermidade. O objetivo do presente estudo é avaliar o estado nutricional de crianças e adolescentes portadores de BO, e, analisar a associação com aspectos clínicos e nutricionais. Para tanto, foi realizado estudo transversal em crianças (<10 anos) e adolescentes (10-18 anos), com diagnóstico clínico/tomográfico de BO, em acompanhamento ambulatorial. Para a determinação do estado nutricional nas crianças foram analisados os escores-Z de peso por idade (ZPI), estatura por idade (ZEI) e peso por estatura (ZPE), e nos adolescentes analisou-se o ZEI e a distribuição dos percentis do Índice de Massa Corporal (IMC). Entre os ≤ 5 anos, os índices foram avaliados com base no padrão da Organização Mundial da Saúde (WHO, 2006), e, a partir dos cinco anos adotou-se a referência do Centers for Disease Control (CDC, 2000). Na avaliação da composição corporal, adotou-se a referência de Frisancho, 1990, foram analisadas as dobras cutâneas tricipital (DCT) e subescapular (DCS) e a soma das duas (SDCTS) para reserva de gordura e a circunferência muscular do braço (CMB) para determinar reserva muscular. O consumo alimentar foi identificado pelo recordatório alimentar de 24 horas (RA24H). A função pulmonar foi avaliada, em pacientes maiores de oito anos, onde se realizou a espirometria e o teste de caminhada de 6 minutos (TC6). Na avaliação do estado nutricional, destaca-se o alto percentual de indivíduos com desnutrição e/ou risco para desnutrição 21,7% e 17,5% respectivamente. Encontrou-se um percentual de pacientes com 8,8% de sobrepeso e 10,5% de obesidade. Quando estratificados por faixa etária, observou-se nas crianças, que o PI e o EI apresentaram maior percentual de desnutrição 21,6% e 16,2%, respectivamente, enquanto que o PE subestimou o diagnóstico de desnutrição. Entre os adolescentes, a aplicação do IMC demonstrou um alto percentual de pacientes com desnutrição (25%) e risco para desnutrição (20%). Quanto a composição corporal, 51% dos indivíduos apresentaram desnutrição por baixa reserva muscular estimada pela CMB, e a maioria dos pacientes apresentou reserva de gordura dentro dos valores de normalidade, quando avaliada por DCT, DCS e SDCTS (68,4%, 64,9% e 63,2%, respectivamente). No que se refere ao consumo alimentar, a metade dos pacientes relataram apresentar ingestão energética abaixo do recomendado. Na avaliação da função pulmonar, observou-se alto percentual de distúrbio obstrutivo moderado (53,5%) e grave (28,5%) (Espirometria VEF1%), e, no desempenho ao exercício (TC6) a maioria dos pacientes (59,2%) apresentou resultados inferiores aos valores de referência. O prejuízo da função pulmonar indicado pelo VEF1% se associou com menor desempenho ao… Advisors/Committee Members: Fischer, Gilberto Bueno.

Subjects/Keywords: Bronquiolite obliterante; Bronchiolitis obliterans; Nutritional status; Criança; Adolescente; Body composition; Food consumption; Consumo de alimento; Estado nutricional; Respiratory function tests; Composição corporal; Teste de função respiratória

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bosa, V. L. (2008). Avaliação nutricional de crianças e adolescentes portadores de bronquiolite obliterante pós-infecciosa. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/13565

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bosa, Vera Lúcia. “Avaliação nutricional de crianças e adolescentes portadores de bronquiolite obliterante pós-infecciosa.” 2008. Thesis, Universidade do Rio Grande do Sul. Accessed February 28, 2021. http://hdl.handle.net/10183/13565.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bosa, Vera Lúcia. “Avaliação nutricional de crianças e adolescentes portadores de bronquiolite obliterante pós-infecciosa.” 2008. Web. 28 Feb 2021.

Vancouver:

Bosa VL. Avaliação nutricional de crianças e adolescentes portadores de bronquiolite obliterante pós-infecciosa. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2008. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10183/13565.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bosa VL. Avaliação nutricional de crianças e adolescentes portadores de bronquiolite obliterante pós-infecciosa. [Thesis]. Universidade do Rio Grande do Sul; 2008. Available from: http://hdl.handle.net/10183/13565

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade do Rio Grande do Sul

16. Mattiello, Rita. Caracterização da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.

Degree: 2011, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/35037

►

Objetivos: Caracterizar a função pulmonar (FP) de crianças e adolescentes com Bronquiolite Obliterante Pós-infecciosa (BOPI), identificar possíveis fatores de risco para pior FP e avaliar… (more)

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Objetivos: Caracterizar a função pulmonar (FP) de crianças e adolescentes com Bronquiolite Obliterante Pós-infecciosa (BOPI), identificar possíveis fatores de risco para pior FP e avaliar se as anormalidades encontradas na tomografia computadorizada do tórax dos primeiros anos de vida podem antecipar pior função pulmonar (FP) uma década depois. Métodos: Foi avaliada a FP de setenta e sete crianças com idades de 8 a 18 anos por meio de espirometria e pletismografia, incluindo fluxos expiratórios forçados, volumes pulmonares e resistências da via aérea. Comparamos as imagens de tomografia (TC) de 21 crianças com BOPI, realizadas nos primeiros três anos de vida, com dados atuais de FP (VEF1). Para avaliar as imagens de TC, utilizou-se o escore modificado de Bhalla. A regressão de Poisson foi utilizada para estimar os potenciais fatores de risco para pior função pulmonar assim como para estimar se pior TC podia antecipar pior FP. Resultados: Os resultados da FP demonstraram que os pacientes apresentam uma diminuição importante nos fluxos expiratórios, assim como um aumento no volume residual e na resistência específica, característicos de doença obstrutiva das vias aéreas. Nenhum dos fatores de risco avaliados apresentou associação significativa com a pior função pulmonar. O valor da razão de prevalência dos achados tomográficos para pior FP uma década depois foi de 1,17 (95% IC 1,02-1,34; p=0,002). Conclusão: Crianças com BOPI apresentam um comprometimento grave da função pulmonar caracterizado por uma obstrução importante das vias aéreas e um expressivo aumento do volume residual e da resistência. Fatores de risco conhecidos para doença respiratória não parecem estar associados com pior função pulmonar, mas os achados tomográficos nos seus primeiros anos de vida parecem antecipar o estado da FP no futuro.

Aims: To characterize the lung function (LF) of children and adolescents with Post-Infectious Bronchiolitis Obliterans, to study risk factors for worst LF and to assess if abnormalities found in their chest computed tomographies (CT) from early years can anticipate LF a decade later. Methods: Seventy-seven children and adolescents from 8 to 18 years of age had their LF assessed by spirometry and plethysmography, including forced expiratory flows, lung volumes and airway resistance. Chest CT findings obtained within the first three years of life of twenty-one subjects were used to compare it with their actual LF (FEV1); a modified Bhalla score was used to assess chest CT. Poisson regression was used to estimate potential risk factors for worst LF as well as to estimate if worst CT findings could anticipate worst LF. Results: Lung function was characterized by a marked reduction in forced expiratory flows and as well as an important increase in residual volume and specific airway resistance, characteristic of an obstructive airway disease. None of the assessed risk factors was significantly associated to worst LF; CT findings showed a prevalence ratio of 1,17 (CI 95% 1,02 to 1,34; p=0,002) for worst LF a decade…

Advisors/Committee Members: Fischer, Gilberto Bueno.

Subjects/Keywords: Bronchiolitis obliterans; Bronquiolite obliterante; Criança; Children; Lung function tests; Adolescente; Tomografia computadorizada; Tomography; Testes de função respiratória; X-rays; Fatores de risco

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APA (6^th Edition):

Mattiello, R. (2011). Caracterização da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/35037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mattiello, Rita. “Caracterização da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.” 2011. Thesis, Universidade do Rio Grande do Sul. Accessed February 28, 2021. http://hdl.handle.net/10183/35037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mattiello, Rita. “Caracterização da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa.” 2011. Web. 28 Feb 2021.

Vancouver:

Mattiello R. Caracterização da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2011. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10183/35037.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mattiello R. Caracterização da função pulmonar em crianças e adolescentes com bronquiolite obliterante pós-infecciosa. [Thesis]. Universidade do Rio Grande do Sul; 2011. Available from: http://hdl.handle.net/10183/35037

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

17. Ohana, Mickaël. Imagerie de la ventilation par tomodensitométrie double énergie simple source avec inhalation de gaz noble : optimisation du protocole et résultats préliminaires : Simple source dual energy ventilation imaging after noble gas inhalation : protocol optimisation and preliminary results.

Degree: Docteur es, Recherche clinique et innovation technologique, 2016, Université de Strasbourg

URL: http://www.theses.fr/2016STRAD015

►

Ce travail portant sur l’imagerie tomodensitométrique double énergie de la ventilation a permis d’établir les points suivants :• L’irradiation d’un examen thoracique acquis en double… (more)

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Ce travail portant sur l’imagerie tomodensitométrique double énergie de la ventilation a permis d’établir les points suivants :• L’irradiation d’un examen thoracique acquis en double énergie peut être abaissée à celle d’un examen acquis en simple énergie, grâce à l’utilisation de la reconstruction itérative.• L’analyse qualitative du parenchyme pulmonaire en imagerie double énergie doit se faire sur les reconstructions monochromatiques 50-55keV.• L’atténuation théorique maximale du Krypton dosé à 80% est modérément inférieure à celle du Xénon dosé à 30%.• La décomposition des matériaux en tomodensitométrie double énergie simple source est possible sur le Xénon et le Krypton.• L’utilisation d’un produit de contraste gazeux n’a pas d’impact significatif sur le Workflow en routine clinique.• Le Krypton est cliniquement sûr à la dose de 80%.• La technique ne permet pas de détecter le Krypton au-delà de la carène de manière satisfaisante, probablement en raison d’une concentration en gaz atteinte insuffisante.• Le recalage élastique augmente les performances diagnostiques de détection de la bronchiolite oblitérante par rapport à une simple analyse visuelle.

This work on dual energy CT ventilation imaging has established the following:• The radiation dose of a dual energy chest CT can be reduced to that of a single energy examination through the use of iterative reconstruction.• The qualitative analysis of the lung parenchyma should be made on the 50-55keV monochromatic reconstructions.• The maximum theoretical attenuation obtained with 80% Krypton is moderately inferior to that of 30% Xenon.• Dual energy material decomposition of Xenon and Krypton is efficient with a single source technique.• The use of a gaseous contrast agent has no significant impact on the workflow in the clinical setting.• The Krypton is safe at 80% concentration.• The technique does not satisfactorily detect Krypton beyond the carina, probably due to insufficient gas concentration.• The elastic registration increases the diagnostic performance of bronchiolitis obliterans syndrome detection, compared to a simple visual analysis.

Advisors/Committee Members: Heitz, Fabrice (thesis director), Roy, Catherine (thesis director).

Subjects/Keywords: Tomodensitométrie; Double énergie; Ventilation; Krypton; Irradiation; Contraste; Recalage; Greffe pulmonaire; Bronchiolite oblitérante; Computed tomography; Dual Energy; Ventilation; Krypton; Radiation dosage; Contrast agent; Registration techniques; Lung transplantation; Bronchiolitis obliterans; 617.9; 621.3

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ohana, M. (2016). Imagerie de la ventilation par tomodensitométrie double énergie simple source avec inhalation de gaz noble : optimisation du protocole et résultats préliminaires : Simple source dual energy ventilation imaging after noble gas inhalation : protocol optimisation and preliminary results. (Doctoral Dissertation). Université de Strasbourg. Retrieved from http://www.theses.fr/2016STRAD015

Chicago Manual of Style (16^th Edition):

Ohana, Mickaël. “Imagerie de la ventilation par tomodensitométrie double énergie simple source avec inhalation de gaz noble : optimisation du protocole et résultats préliminaires : Simple source dual energy ventilation imaging after noble gas inhalation : protocol optimisation and preliminary results.” 2016. Doctoral Dissertation, Université de Strasbourg. Accessed February 28, 2021. http://www.theses.fr/2016STRAD015.

MLA Handbook (7^th Edition):

Ohana, Mickaël. “Imagerie de la ventilation par tomodensitométrie double énergie simple source avec inhalation de gaz noble : optimisation du protocole et résultats préliminaires : Simple source dual energy ventilation imaging after noble gas inhalation : protocol optimisation and preliminary results.” 2016. Web. 28 Feb 2021.

Vancouver:

Ohana M. Imagerie de la ventilation par tomodensitométrie double énergie simple source avec inhalation de gaz noble : optimisation du protocole et résultats préliminaires : Simple source dual energy ventilation imaging after noble gas inhalation : protocol optimisation and preliminary results. [Internet] [Doctoral dissertation]. Université de Strasbourg; 2016. [cited 2021 Feb 28]. Available from: http://www.theses.fr/2016STRAD015.

Council of Science Editors:

Ohana M. Imagerie de la ventilation par tomodensitométrie double énergie simple source avec inhalation de gaz noble : optimisation du protocole et résultats préliminaires : Simple source dual energy ventilation imaging after noble gas inhalation : protocol optimisation and preliminary results. [Doctoral Dissertation]. Université de Strasbourg; 2016. Available from: http://www.theses.fr/2016STRAD015

18. DerHovanessian, Ariss. Primary Graft Dysfunction and Long-Term Outcomes Following Lung Transplantation.

Degree: Clinical Research, 2012, UCLA

URL: http://www.escholarship.org/uc/item/3rv9r548

► Background: Primary graft dysfunction (PGD) is an early complication of lung transplantation associated with poor early outcomes, however less is known about its prolonged effects… (more)

▼ Background: Primary graft dysfunction (PGD) is an early complication of lung transplantation associated with poor early outcomes, however less is known about its prolonged effects on morbidity and mortality. We hypothesized that PGD is associated with long-term mortality and chronic rejection in the form of bronchiolitis obliterans syndrome. Methods: A retrospective study of 279 adult lung transplant recipients between 2000 and 2007 was performed. PGD grade was determined both immediately after transplantation (T0) and at 72 hours post-transplant (T72). Chronic rejection defined as stage 1 bronchiolitis obliterans syndrome (BOS), long-term mortality in 90-day survivors were modeled using competing risk and extended Cox models with time-dependent covariates with internal validation performed via bootstrapping. Cumulative incidence plots for the outcome of BOS were created for each PGD grade and at both time points.Results: We found that there was a significant stepwise increase in the hazard ratio for both BOS and mortality with increasing PGD grade. This association was most severe among patients with grade 3 PGD at T72, and the association with BOS persisted in adjusted multivariable models with a hazard ratio of 3.75 (95% CI 1.11-21.4, p < 0.001). Stratified analyses in recipients with either single or bilateral transplants were also consistent with this finding. The association between PGD and long-term mortality also persisted after adjustment for baseline covariates, but in multivariable models of mortality that also incorporated BOS as a time-dependent variable, PGD was no longer significantly associated with mortality. Conclusions: These results suggest that severe PGD in the early perioperative period may play a causal role in the subsequent development of BOS after lung transplantation in some patients, and that the development of BOS in patients with PGD may account for increased rates of death even among recipients with severe PGD who survive the early perioperative period.

Subjects/Keywords: Medicine; Bronchiolitis obliterans syndrome; Lung transplantation; Primary graft dysfunction

…11 years (6, 7). Bronchiolitis Obliterans Syndrome The leading cause of death… …to chronic rejection in the form of bronchiolitis obliterans syndrome (BOS)… …mortality continues to be chronic allograft rejection in the form of bronchiolitis obliterans… …irreversible fibrosis and obliteration of the bronchioles, referred to as obliterative bronchiolitis…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

DerHovanessian, A. (2012). Primary Graft Dysfunction and Long-Term Outcomes Following Lung Transplantation. (Thesis). UCLA. Retrieved from http://www.escholarship.org/uc/item/3rv9r548

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DerHovanessian, Ariss. “Primary Graft Dysfunction and Long-Term Outcomes Following Lung Transplantation.” 2012. Thesis, UCLA. Accessed February 28, 2021. http://www.escholarship.org/uc/item/3rv9r548.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DerHovanessian, Ariss. “Primary Graft Dysfunction and Long-Term Outcomes Following Lung Transplantation.” 2012. Web. 28 Feb 2021.

Vancouver:

DerHovanessian A. Primary Graft Dysfunction and Long-Term Outcomes Following Lung Transplantation. [Internet] [Thesis]. UCLA; 2012. [cited 2021 Feb 28]. Available from: http://www.escholarship.org/uc/item/3rv9r548.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DerHovanessian A. Primary Graft Dysfunction and Long-Term Outcomes Following Lung Transplantation. [Thesis]. UCLA; 2012. Available from: http://www.escholarship.org/uc/item/3rv9r548

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Illinois – Chicago

19. Metwally, Ahmed. Computational Methods for Longitudinal Microbiome Analysis: Identification, Modeling, and Classification.

Degree: 2018, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/22939

► The microbiome plays a vital role in host-immune responses resulting in significant effects on host health. Dysbiosis of the microbiome has been linked to diseases… (more)

▼ The microbiome plays a vital role in host-immune responses resulting in significant effects on host health. Dysbiosis of the microbiome has been linked to diseases including asthma, obesity, diabetes, and inflammatory bowel disease. Over the past decade, culture-independent sequencing methods have revolutionized microbiome studies through identification of the genetic content of microbial communities in the form of millions to billions of short DNA sequences. The sequences derived from the microbiome originate from thousands of different species that need to be identified, quantified, and compared over time among disease phenotypes. These analyses can detect biomarkers that may be used for microbial reconstitution through bacteriotherapy, probiotics, or antibiotics. Current taxonomic identification methods that achieve high precision can lack sensitivity in some applications. Conversely, methods with high sensitivity can suffer from low precision and require long computation time. Thus, highly accurate and sensitive taxonomic identification methods are needed. Furthermore, in longitudinal studies, sample collection suffers from all forms of variability such as a different number of subjects per phenotypic group, a different number of samples per subject, and samples not collected at consistent time points. These inconsistencies make current analysis methods unsuitable and create opportunities for the development of new methods. In addition, given the strong association between microbiome and disease, computational models can be built to predict disease status or prognosis using longitudinal microbial profiles. In this thesis, we discuss the computational methods and tools we have developed that improve both the characterization and longitudinal analysis of the microbiome. The first method, WEVOTE, classifies microbial sequences into taxonomic units with both high precision and high sensitivity. The second method, MetaLonDA, identifies time intervals of differentially abundant microbial features in longitudinal studies. The third method is a computational framework to predict host clinical phenotype from longitudinal microbiome profiles via deep learning approach. Finally, using these methods and tools, we identified microbiome dynamics suggestive of the development of bronchiolitis obliterans syndrome in pediatric lung transplant recipients, insights that can be leveraged to improve lung transplant outcomes across life span. Advisors/Committee Members: Dai, Yang (advisor), Perkins, David L. (advisor), Liang, Jie (committee member), Finn, Patricia W. (committee member), DasGupta, Bhaskar (committee member), Yang, Jie (committee member), Dai, Yang (chair).

Subjects/Keywords: Metagenomics; Microbiome; Taxonomic Classification; Sequence Alignment; Differential Abundance; Longitudinal Studies; Time Series; Smoothing Splines; Food Allergy; deep Learning; LSTM; Autoencoder; Cystic Fibrosis; Bronchiolitis Obliterans Syndrome; Lung Transplantation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Metwally, A. (2018). Computational Methods for Longitudinal Microbiome Analysis: Identification, Modeling, and Classification. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22939

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Metwally, Ahmed. “Computational Methods for Longitudinal Microbiome Analysis: Identification, Modeling, and Classification.” 2018. Thesis, University of Illinois – Chicago. Accessed February 28, 2021. http://hdl.handle.net/10027/22939.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Metwally, Ahmed. “Computational Methods for Longitudinal Microbiome Analysis: Identification, Modeling, and Classification.” 2018. Web. 28 Feb 2021.

Vancouver:

Metwally A. Computational Methods for Longitudinal Microbiome Analysis: Identification, Modeling, and Classification. [Internet] [Thesis]. University of Illinois – Chicago; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10027/22939.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Metwally A. Computational Methods for Longitudinal Microbiome Analysis: Identification, Modeling, and Classification. [Thesis]. University of Illinois – Chicago; 2018. Available from: http://hdl.handle.net/10027/22939

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Kastelijn, E.A. Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis.

Degree: 2012, University Utrecht

URL: https://dspace.library.uu.nl/handle/1874/218111 ; URN:NBN:NL:UI:10-1874-218111 ; urn:isbn:978-94-6108-250-3 ; URN:NBN:NL:UI:10-1874-218111 ; https://dspace.library.uu.nl/handle/1874/218111

► Lung transplantation is the treatment of choice for patients with end-stage lung disease. However, long-term survival is limited due to the development of chronic rejection… (more)

▼ Lung transplantation is the treatment of choice for patients with end-stage lung disease. However, long-term survival is limited due to the development of chronic rejection in the donor lung of the transplant recipient, called bronchiolitis obliterans syndrome (BOS). BOS is diagnosed after lung transplantation when a decline in lung function occurs, which is not due to rejection, infection or problems of the bronchial anastomosis. The development of BOS is characterized by persistent injury of the airway epithelium that is caused by several factors. This process leads to inflammation and remodeling, which is followed by an aberrant repair response, and finally fibrosis and occlusion of the small airways of the allograft. When BOS is diagnosed, the process is already at an advanced and mostly irreversible stage and treatment options are limited. The current status of diagnosis of BOS clearly indicates the need for biomarkers in serum and DNA that may detect processes leading to BOS before the decline in lung function occurs. These unmet needs are the basis of this thesis. TLRs are critical molecules for activation of the innate immune system by recognition of pathogens, and they can prevent the induction of allograft tolerance. Genetic polymorphisms in Toll-like receptor (TLR)2, TLR4 and TLR9 might contribute to patients’ susceptibility for BOS. These genetic polymorphisms could predispose to increased secretion of pro-inflammatory cytokines, causing injury and inflammation of the airway epithelium. The exact role of different types of cytokines in rejection or tolerance of the allograft is under debate. We showed that the T helper (Th)1 cytokines were similar between patients who developed BOS (BOSpos)and those who did not (BOSneg)patients. However, the Th2 cytokines revealed a different pattern between these two groups. This suggests that Th2 cytokines are involved in the process of chronic rejection, possibly due to the inhibition of transplant tolerance, the absence of inhibition of the Th1 response and the influence on proliferation of regulatory T-cells. In relation to excessive injury and chronic inflammation, the process of fibrogenesis is considered to be of central importance to the development of BOS. Normally, after injury of the airway epithelium an adequate repair mechanism is required to prevent fibrogenesis. BOSpos patients, however, seem to have an impaired repair mechanism and a profibrotic airway milieu. They had a different genotype distribution of matrix metalloproteinase (MMP)7 and lower levels of MMP-7 than BOSneg patients which might contribute to an impaired repair mechanism of the airway epithelium. Besides, there is more degradation and turnover of the extracellular matrix in BOSpos patients than in BOSneg patients as shown by increased levels of MMP-9. Though, the functionality of the genetic polymorphisms in the caveolin-1 (CAV1) gene is not known, it might contribute to fibrogenesis as well through the transforming growth factor beta signaling pathway. In… Advisors/Committee Members: Grutters, J.C., Lammers, J.W.J., Ruven, H.J.T., Moorsel, C.H.M. van.

Subjects/Keywords: lung transplantation; bronchiolitis obliterans syndrome; chronic rejection; biomarkers; genetic polymorphism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kastelijn, E. A. (2012). Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/218111 ; URN:NBN:NL:UI:10-1874-218111 ; urn:isbn:978-94-6108-250-3 ; URN:NBN:NL:UI:10-1874-218111 ; https://dspace.library.uu.nl/handle/1874/218111

Chicago Manual of Style (16^th Edition):

Kastelijn, E A. “Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis.” 2012. Doctoral Dissertation, University Utrecht. Accessed February 28, 2021. https://dspace.library.uu.nl/handle/1874/218111 ; URN:NBN:NL:UI:10-1874-218111 ; urn:isbn:978-94-6108-250-3 ; URN:NBN:NL:UI:10-1874-218111 ; https://dspace.library.uu.nl/handle/1874/218111.

MLA Handbook (7^th Edition):

Kastelijn, E A. “Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis.” 2012. Web. 28 Feb 2021.

Vancouver:

Kastelijn EA. Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis. [Internet] [Doctoral dissertation]. University Utrecht; 2012. [cited 2021 Feb 28]. Available from: https://dspace.library.uu.nl/handle/1874/218111 ; URN:NBN:NL:UI:10-1874-218111 ; urn:isbn:978-94-6108-250-3 ; URN:NBN:NL:UI:10-1874-218111 ; https://dspace.library.uu.nl/handle/1874/218111.

Council of Science Editors:

Kastelijn EA. Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis. [Doctoral Dissertation]. University Utrecht; 2012. Available from: https://dspace.library.uu.nl/handle/1874/218111 ; URN:NBN:NL:UI:10-1874-218111 ; urn:isbn:978-94-6108-250-3 ; URN:NBN:NL:UI:10-1874-218111 ; https://dspace.library.uu.nl/handle/1874/218111

University of Helsinki

21. Jäämaa, Salla. Detection of Bile Acids in Bronchoalveolar Lavage Fluid as a Marker of Gastric Aspiration in Lung Allograft Recipients.

Degree: Institute of Clinical Medicine; Helsingfors universitet, Medicinska fakulteten, Institutionen för klinisk medicin, 2010, University of Helsinki

URL: http://hdl.handle.net/10138/155923

► Lung transplantation (LTx) is a generally accepted therapy for end-stage lung patients meeting the international criterias. Chronic dysfunction of the allograft, called Brochiolitis Obliterans Syndrome… (more)

Subjects/Keywords: Lung Transplantation; Bronchiolitis Obliterans; Gastroesophageal Reflux desease; Bronchoalveolar Lavage Fluid; Bile acids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jäämaa, S. (2010). Detection of Bile Acids in Bronchoalveolar Lavage Fluid as a Marker of Gastric Aspiration in Lung Allograft Recipients. (Masters Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/10138/155923

Chicago Manual of Style (16^th Edition):

Jäämaa, Salla. “Detection of Bile Acids in Bronchoalveolar Lavage Fluid as a Marker of Gastric Aspiration in Lung Allograft Recipients.” 2010. Masters Thesis, University of Helsinki. Accessed February 28, 2021. http://hdl.handle.net/10138/155923.

MLA Handbook (7^th Edition):

Jäämaa, Salla. “Detection of Bile Acids in Bronchoalveolar Lavage Fluid as a Marker of Gastric Aspiration in Lung Allograft Recipients.” 2010. Web. 28 Feb 2021.

Vancouver:

Jäämaa S. Detection of Bile Acids in Bronchoalveolar Lavage Fluid as a Marker of Gastric Aspiration in Lung Allograft Recipients. [Internet] [Masters thesis]. University of Helsinki; 2010. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10138/155923.

Council of Science Editors:

Jäämaa S. Detection of Bile Acids in Bronchoalveolar Lavage Fluid as a Marker of Gastric Aspiration in Lung Allograft Recipients. [Masters Thesis]. University of Helsinki; 2010. Available from: http://hdl.handle.net/10138/155923

22. Kastelijn, E.A. Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis.

Degree: 2012, University Utrecht

URL: https://dspace.library.uu.nl/handle/1874/218111 ; URN:NBN:NL:UI:10-1874-218111 ; 1874/218111 ; urn:isbn:9789461082503 ; URN:NBN:NL:UI:10-1874-218111 ; https://dspace.library.uu.nl/handle/1874/218111

► Lung transplantation is the treatment of choice for patients with end-stage lung disease. However, long-term survival is limited due to the development of chronic rejection… (more)

▼ Lung transplantation is the treatment of choice for patients with end-stage lung disease. However, long-term survival is limited due to the development of chronic rejection in the donor lung of the transplant recipient, called bronchiolitis obliterans syndrome (BOS). BOS is diagnosed after lung transplantation when a decline in lung function occurs, which is not due to rejection, infection or problems of the bronchial anastomosis. The development of BOS is characterized by persistent injury of the airway epithelium that is caused by several factors. This process leads to inflammation and remodeling, which is followed by an aberrant repair response, and finally fibrosis and occlusion of the small airways of the allograft. When BOS is diagnosed, the process is already at an advanced and mostly irreversible stage and treatment options are limited. The current status of diagnosis of BOS clearly indicates the need for biomarkers in serum and DNA that may detect processes leading to BOS before the decline in lung function occurs. These unmet needs are the basis of this thesis. TLRs are critical molecules for activation of the innate immune system by recognition of pathogens, and they can prevent the induction of allograft tolerance. Genetic polymorphisms in Toll-like receptor (TLR)2, TLR4 and TLR9 might contribute to patients’ susceptibility for BOS. These genetic polymorphisms could predispose to increased secretion of pro-inflammatory cytokines, causing injury and inflammation of the airway epithelium. The exact role of different types of cytokines in rejection or tolerance of the allograft is under debate. We showed that the T helper (Th)1 cytokines were similar between patients who developed BOS (BOSpos)and those who did not (BOSneg)patients. However, the Th2 cytokines revealed a different pattern between these two groups. This suggests that Th2 cytokines are involved in the process of chronic rejection, possibly due to the inhibition of transplant tolerance, the absence of inhibition of the Th1 response and the influence on proliferation of regulatory T-cells. In relation to excessive injury and chronic inflammation, the process of fibrogenesis is considered to be of central importance to the development of BOS. Normally, after injury of the airway epithelium an adequate repair mechanism is required to prevent fibrogenesis. BOSpos patients, however, seem to have an impaired repair mechanism and a profibrotic airway milieu. They had a different genotype distribution of matrix metalloproteinase (MMP)7 and lower levels of MMP-7 than BOSneg patients which might contribute to an impaired repair mechanism of the airway epithelium. Besides, there is more degradation and turnover of the extracellular matrix in BOSpos patients than in BOSneg patients as shown by increased levels of MMP-9. Though, the functionality of the genetic polymorphisms in the caveolin-1 (CAV1) gene is not known, it might contribute to fibrogenesis as well through the transforming growth factor beta signaling pathway. In… Advisors/Committee Members: Grutters, J.C., Lammers, J.W.J., Ruven, H.J.T., Moorsel, C.H.M. van.

Subjects/Keywords: lung transplantation; bronchiolitis obliterans syndrome; chronic rejection; biomarkers; genetic polymorphism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kastelijn, E. A. (2012). Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/218111 ; URN:NBN:NL:UI:10-1874-218111 ; 1874/218111 ; urn:isbn:9789461082503 ; URN:NBN:NL:UI:10-1874-218111 ; https://dspace.library.uu.nl/handle/1874/218111

Chicago Manual of Style (16^th Edition):

Kastelijn, E A. “Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis.” 2012. Doctoral Dissertation, University Utrecht. Accessed February 28, 2021. https://dspace.library.uu.nl/handle/1874/218111 ; URN:NBN:NL:UI:10-1874-218111 ; 1874/218111 ; urn:isbn:9789461082503 ; URN:NBN:NL:UI:10-1874-218111 ; https://dspace.library.uu.nl/handle/1874/218111.

MLA Handbook (7^th Edition):

Kastelijn, E A. “Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis.” 2012. Web. 28 Feb 2021.

Vancouver:

Kastelijn EA. Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis. [Internet] [Doctoral dissertation]. University Utrecht; 2012. [cited 2021 Feb 28]. Available from: https://dspace.library.uu.nl/handle/1874/218111 ; URN:NBN:NL:UI:10-1874-218111 ; 1874/218111 ; urn:isbn:9789461082503 ; URN:NBN:NL:UI:10-1874-218111 ; https://dspace.library.uu.nl/handle/1874/218111.

Council of Science Editors:

Kastelijn EA. Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis. [Doctoral Dissertation]. University Utrecht; 2012. Available from: https://dspace.library.uu.nl/handle/1874/218111 ; URN:NBN:NL:UI:10-1874-218111 ; 1874/218111 ; urn:isbn:9789461082503 ; URN:NBN:NL:UI:10-1874-218111 ; https://dspace.library.uu.nl/handle/1874/218111

University of Lund

23. Fakhro, Mohammed. Lung transplantation: improving clinical outcome and donor organ scarcity.

Degree: 2019, University of Lund

URL: https://lup.lub.lu.se/record/f4436000-4c52-40ec-ba7c-5fca9a44b8a5 ; https://portal.research.lu.se/ws/files/62596902/e_nailing_mohammed.pdf

Subjects/Keywords: Surgery; donation after cardiac death; ex vivo lung perfusion; Lung transplantation; survival; outcome; bronchiolitis obliterans syndrome; donor organ scarcity; graft preservation

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APA (6^th Edition):

Fakhro, M. (2019). Lung transplantation: improving clinical outcome and donor organ scarcity. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/f4436000-4c52-40ec-ba7c-5fca9a44b8a5 ; https://portal.research.lu.se/ws/files/62596902/e_nailing_mohammed.pdf

Chicago Manual of Style (16^th Edition):

Fakhro, Mohammed. “Lung transplantation: improving clinical outcome and donor organ scarcity.” 2019. Doctoral Dissertation, University of Lund. Accessed February 28, 2021. https://lup.lub.lu.se/record/f4436000-4c52-40ec-ba7c-5fca9a44b8a5 ; https://portal.research.lu.se/ws/files/62596902/e_nailing_mohammed.pdf.

MLA Handbook (7^th Edition):

Fakhro, Mohammed. “Lung transplantation: improving clinical outcome and donor organ scarcity.” 2019. Web. 28 Feb 2021.

Vancouver:

Fakhro M. Lung transplantation: improving clinical outcome and donor organ scarcity. [Internet] [Doctoral dissertation]. University of Lund; 2019. [cited 2021 Feb 28]. Available from: https://lup.lub.lu.se/record/f4436000-4c52-40ec-ba7c-5fca9a44b8a5 ; https://portal.research.lu.se/ws/files/62596902/e_nailing_mohammed.pdf.

Council of Science Editors:

Fakhro M. Lung transplantation: improving clinical outcome and donor organ scarcity. [Doctoral Dissertation]. University of Lund; 2019. Available from: https://lup.lub.lu.se/record/f4436000-4c52-40ec-ba7c-5fca9a44b8a5 ; https://portal.research.lu.se/ws/files/62596902/e_nailing_mohammed.pdf

University of Sydney

24. Htun, Christopher. The time course of changes in peripheral airway function after allogeneic haematopoietic stem cell transplantation .

Degree: University of Sydney

URL: http://hdl.handle.net/2123/21790

► The work presented in this thesis explores the potential of multiple breath nitrogen washout (MBNW) and forced oscillation technique (FOT) indices for early detection of… (more)

▼ The work presented in this thesis explores the potential of multiple breath nitrogen washout (MBNW) and forced oscillation technique (FOT) indices for early detection of peripheral airway dysfunction after allogeneic haematopoietic stem cell transplantation (allo-HSCT). These tests have been shown to be sensitive to peripheral airways involvement in a number of respiratory diseases including asthma, Chronic Obstructive Pulmonary Disease (COPD) and cystic fibrosis (CF), but are currently underutilised in the allo-HSCT setting. We first investigated the effect of normal ageing on peripheral airway function indices. The effect of ageing on normative data in FOT indices, respiratory resistance (Rrs) and reactance (Xrs), across the age range 18-92 years, had already been published by our research group in 2010. We therefore aimed to define the corresponding effects of aging on MBNW indices reflecting ventilation inhomogeneity arising in conducting airways (Scond), and more distal peripheral airways (Sacin), as well as globally (Lung Clearance index, LCI), across a corresponding age range of 20-90 years. Previous studies had shown that Sacin, Scond and LCI deteriorated minimally in healthy young to middle aged adults. In contrast, we demonstrated that normal ageing was a prominent contributor to worsening peripheral airway function in later life. In particular, there was an accelerated deterioration of Sacin after age 64 years, while Scond and LCI increased linearly with advancing age. These findings highlighted the importance of ageappropriate normative values extending into the elderly age range for MBNW indices. Additionally, given the accelerated deterioration of Sacin in older adults, we investigated the contribution of age-associated changes in peripheral airway function to changes in conventional pulmonary function indices reflecting expiratory airflow (FEV1/FVC) and gas trapping (RV/TLC). We demonstrated statistically significant relationships between higher Sacin and Scond and FEV1/FVC, as well as RV/TLC. These findings provided novel evidence of the important contribution of peripheral airway function to changes in conventional pulmonary function indices with ageing. We then conducted a longitudinal observational study of allo-HSCT recipients from the Haematology Department at Royal North Shore Hospital. Z-scores for MBNW indices were calculated from the normative dataset previously described. We aimed to determine the longitudinal changes in MBNW, FOT and spirometric indices, from baseline (pre-transplant), over a 36 month period following allo-HSCT. Within this large adult allo-HSCT cohort, we demonstrated that distal acinar ventilation inhomogeneity (Sacin) deteriorated post allo-HSCT, and that this deterioration occurred at an earlier stage than statistically significant changes in spirometric indices or the onset of respiratory symptoms. These findings provided novel longitudinal evidence supporting the beneficial role of MBNW in the detection of early peripheral airway dysfunction after allo-HSCT. Finally,…

Subjects/Keywords: small airways; peripheral airways; multiple breath nitrogen washout (MBNW); bronchiolitis obliterans syndrome (BOS); ventilation inhomogeneity

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APA (6^th Edition):

Htun, C. (n.d.). The time course of changes in peripheral airway function after allogeneic haematopoietic stem cell transplantation . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/21790

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Htun, Christopher. “The time course of changes in peripheral airway function after allogeneic haematopoietic stem cell transplantation .” Thesis, University of Sydney. Accessed February 28, 2021. http://hdl.handle.net/2123/21790.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Htun, Christopher. “The time course of changes in peripheral airway function after allogeneic haematopoietic stem cell transplantation .” Web. 28 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Htun C. The time course of changes in peripheral airway function after allogeneic haematopoietic stem cell transplantation . [Internet] [Thesis]. University of Sydney; [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2123/21790.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Htun C. The time course of changes in peripheral airway function after allogeneic haematopoietic stem cell transplantation . [Thesis]. University of Sydney; Available from: http://hdl.handle.net/2123/21790

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

25. Hardison, Matthew Thomas. A dual protease inhibitor/receptor antagonist with therapeutic implications for chronic inflammatory lung diseases.

Degree: PhD, 2010, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,1161

►

Chronic neutrophilic inflammation is a hallmark of numerous pulmonary diseases. It is commonly associated with declining lung function, collagen turnover, and increased protease activity. Our… (more)

▼

Chronic neutrophilic inflammation is a hallmark of numerous pulmonary diseases. It is commonly associated with declining lung function, collagen turnover, and increased protease activity. Our laboratory has recently published several articles describing a biologically active collagen breakdown product, proline-glycine-proline (PGP) and its more active amino-terminus acetylated form, N-α-PGP. PGP acts via classical chemokine receptors CXCR1 and 2 to draw neutrophils (PMNs) into sites of inflammation in what is potentially a feed-forward mechanism of disease. The tri-peptide appears to be a bio-marker in certain clinical diseases like cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The present work first details PMN proteases and their mechanism of release, with an emphasis on their role in inflammation. A closer examination is taken of a serine protease, prolyl endopeptidase (PE), that performs the final proteolytic cleavage of PGP from collagen fragments. These experiments detail for the first time that PE is present and active in PMNs. In turn demonstrating that neutrophils contain all of the necessary enzymes to take intact collagen and produce PGP, indicating a possible feed-forward mechanism of PMN inflammation. Additionally, another model of chronic neutrophilic inflammation in pulmonary disease, bronchiolitis obliterans syndrome (BOS) is examined to determine if PGP is a potential mediator of aspects of this condition. Indeed, it appears that at the time of diagnosis of BOS, or chronic rejection of lung transplant, there is an increase in the both the proteases responsible for its production, and PGP itself. Moreover, there is a shift from the traditional PMN chemokine, interleukin-8 (IL-8) to PGP playing the more prominent role in neutrophil migration. Finally, we describe an extremely novel concept of a dual PE inhibitor and CXCR antagonist activity residing in a single compound, benzyloxycarbonyl-proline-prolinal (ZPP). We show that ZPP is capable of blocking both PE activity and generation of PGP, but also CXCR mediated PMN recruitment and directly competes with IL-8 for binding. This work advances the concept of a self sustaining mechanism of chronic neutrophilic inflammation and introduces a novel concept for potential therapeutics directed at blunting the condition.

1 online resource (xv, 149 p.) : ill., digital, PDF file.

Physiology and Biophysics

Joint Health Sciences

UNRESTRICTED

Advisors/Committee Members: Blalock, J. Edwin, Gaggar, Amit<br>, Jackson, Patricia L.<br>, Oparil, Suzanne<br>, Schwiebert, Lisa M.<br>, Sorscher, Eric.

Subjects/Keywords: Bronchiolitis Obliterans – immunology<; br>; Bronchoalveolar Lavage Fluid – chemistry<; br>; Chemotaxis, Leukocyte – immunology<; br>; Collagen – chemistry<; br>; Lung Transplantation – adverse effects<; br>; Neutrophils<; br>; Oligopeptides – analysis<; br>; Proline – analogs & derivatives<; br>; Serine Endopeptidases – metabolism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hardison, M. T. (2010). A dual protease inhibitor/receptor antagonist with therapeutic implications for chronic inflammatory lung diseases. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,1161

Chicago Manual of Style (16^th Edition):

Hardison, Matthew Thomas. “A dual protease inhibitor/receptor antagonist with therapeutic implications for chronic inflammatory lung diseases.” 2010. Doctoral Dissertation, University of Alabama – Birmingham. Accessed February 28, 2021. http://contentdm.mhsl.uab.edu/u?/etd,1161.

MLA Handbook (7^th Edition):

Hardison, Matthew Thomas. “A dual protease inhibitor/receptor antagonist with therapeutic implications for chronic inflammatory lung diseases.” 2010. Web. 28 Feb 2021.

Vancouver:

Hardison MT. A dual protease inhibitor/receptor antagonist with therapeutic implications for chronic inflammatory lung diseases. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2010. [cited 2021 Feb 28]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1161.

Council of Science Editors:

Hardison MT. A dual protease inhibitor/receptor antagonist with therapeutic implications for chronic inflammatory lung diseases. [Doctoral Dissertation]. University of Alabama – Birmingham; 2010. Available from: http://contentdm.mhsl.uab.edu/u?/etd,1161

26. ΒΟΛΟΥΔΑΚΗ, ΑΡΓΥΡΩ. ΜΕΛΕΤΗ ΔΙΑΧΥΤΩΝ ΔΙΑΜΕΣΩΝ ΠΝΕΥΜΟΝΟΠΑΘΕΙΩΝ. ΑΞΙΟΛΟΓΗΣΗ ΜΕ ΥΠΟΛΟΓΙΣΤΙΚΗ ΤΟΜΟΓΡΑΦΙΑΥΨΗΛΗΣ ΕΥΚΡΙΝΕΙΑΣ.

Degree: 1996, Πανεπιστήμιο Κρήτης; University of Crete (UOC)

URL: http://hdl.handle.net/10442/hedi/7421

►

ΣΚΟΠΟΣ: H ΔΙΕΡΕΥΝΗΣΗ ΤΩΝ ΔΙΑΧΥΤΩΝ ΔΙΑΜΕΣΩΝ ΠΝΕΥΜΟΝΟΠΑΘΕΙΩΝ ΜΕ Υ.Τ ΥΨΗΛΗΣ ΕΥΚΡΙΝΕΙΑΣ(ΥΤΥΕ). ΑΣΘΕΝΕΙΣ - ΜΕΘΟΔΟΣ: MΕΛΕΤΗΘΗΚΑΝ 124 ΑΣΘΕΝΕΙΣ ΜΕ ΣΥΜΒΑΤΙΚΗ ΚΑΙ ΥΨΗΛΗΣ ΕΥΚΡΙΝΕΙΑΣ ΥΠΟΛΟΓΙΣΤΙΚΗ ΤΟΜΟΓΡΑΦΙΑ. ΑΠΟΤΕΛΕΣΜΑΤΑ:… (more)

▼

ΣΚΟΠΟΣ: H ΔΙΕΡΕΥΝΗΣΗ ΤΩΝ ΔΙΑΧΥΤΩΝ ΔΙΑΜΕΣΩΝ ΠΝΕΥΜΟΝΟΠΑΘΕΙΩΝ ΜΕ Υ.Τ ΥΨΗΛΗΣ ΕΥΚΡΙΝΕΙΑΣ(ΥΤΥΕ). ΑΣΘΕΝΕΙΣ - ΜΕΘΟΔΟΣ: MΕΛΕΤΗΘΗΚΑΝ 124 ΑΣΘΕΝΕΙΣ ΜΕ ΣΥΜΒΑΤΙΚΗ ΚΑΙ ΥΨΗΛΗΣ ΕΥΚΡΙΝΕΙΑΣ ΥΠΟΛΟΓΙΣΤΙΚΗ ΤΟΜΟΓΡΑΦΙΑ. ΑΠΟΤΕΛΕΣΜΑΤΑ: H YTYE ΑΝΑΔΕΙΚΝΥΕΙ ΠΑΘΟΓΝΩΜΙΚΟ ΠΡΟΤΥΠΟ ΣΤΗΝ ΛΕΜΦΑΓΓΕΙΑΚΗ ΚΑΡΚΙΝΩΜΑΤΩΣΗ. ΠΟΣΟΤΙΚΟΠΟΙΗΣΗ ΤΩΝ ΠΟΛΥΓΩΝΙΚΩΝ ΔΟΜΩΝ ΔΙΑΦΟΡΟΠΟΙΟΥΝ ΤΗ ΝΟΣΟ ΑΠΟ ΤΗΝ ΣΑΡΚΟΕΙΔΩΣΗ. ΟΙ ΜΙΚΡΟΟΖΟΙ ΜΕ ΠΕΡΙΒΡΟΓΧΟΑΓΓΕΙΑΚΗ ΚΑΙ ΥΠΟΥΠΕΖΩΤΙΚΟΤΙΚΗ ΚΑΤΑΝΟΜΗ ΣΥΝΙΣΤΟΥΝ ΤΟ ΧΑΡΑΚΤΗΡΙΣΤΙΚΟ ΠΡΟΤΥΠΟ ΤΗΣ ΣΑΡΚΟΕΙΔΩΣΗΣ. Η ΥΤΥΕ ΑΝΑΔΕΙΚΝΥΕΙ ΤΙΣ ΧΑΡΑΚΤΗΡΙΣΤΙΚΕΣ ΑΛΛΟΙΩΣΕΙΣ ΚΑΙ ΤΗΝ ΥΠΟΥΠΕΖΩΚΟΤΙΚΗ ΕΝΤΟΠΙΣΗ ΤΟΥΣ ΣΤΗΝ ΙΔΙΟΠΑΘΗ ΠΝΕΥΜΟΝΙΚΗ ΙΝΩΣΗ ΟΠΩΣ ΚΑΙ ΤΗΝ ΠΡΩΙΜΗΔΙΑΜΕΣΗ ΔΙΗΘΗΣΗ ΚΑΙ ΒΡΟΓΧΙΟΛΙΚΗ ΣΥΜΜΕΤΟΧΗ ΣΤΙΣ ΚΟΛΛΑΓΟΝΟΠΑΘΕΙΕΣ. ΕΝΑ ΠΡΟΤΥΠΟΚΥΚΛΙΚΩΝ ΠΥΚΝΩΣΕΩΝ ΠΟΥ ΠΕΡΙΒΑΛΛΟΥΝ ΠΕΡΙΟΧΕΣ ΓΑΛΑΚΤΟΧΡΟΟΥ ΥΑΛΟΥ ΘΕΩΡΕΙΤΑΙ ΕΙΔΙΚΟ ΤΗΣ ΑΠΟΦΡΑΚΤΙΚΗΣ ΒΡΟΓΧΙΟΛΙΤΙΔΟΣ ΜΕ ΟΡΓΑΝΟΥΜΕΝΗ ΠΝΕΥΜΟΝΙΑ. ΠΟΛΛΕΣ ΚΥΣΤΕΙΣ ΚΑΙ ΚΟΙΛΟΤΙΚΟΙ ΟΖΟΙ ΑΠΟΤΕΛΟΥΝ ΠΑΘΟΓΝΩΜΟΝΙΚΟ ΕΥΡΗΜΑ ΤΗΣ ΙΣΤΙΟΚΥΤΤΑΡΩΣΗΣ-Χ ΣΤΗΝ ΥΤΥΕ.

ΑIM: TO EVALUATE DIFFUSE INTERSTITIAL LUNG DISEASE BY MEANS OF HRCT. PATIENTS - METHODS: 124 PATIENTS WERE ASSESSED BY HRCT AND CONVENTIONAL CT. RESULTS: LYMPHANGITIC CARCINOMATOSIS PRESENTS SPECIFIC HRCT SIGNS. QUALIFICATION OF POLYGONAL LINES CONTRIBUTES TO DIFFERENTIATION FROM SARCOIDOSIS. THE PRESENCE OF MICRONODULES ALONG BRONCHOVASCULAR BUNDLES AND SUBPLEURAL AREAS IS THE KEY HRCT FINDING IN SARCOIDOSIS. HRCT REVEALS THE CHARACTERISTIC SIGNS OF IDIOPATHIC PULMONARY FIBROSIS AND THEIR SUBPLEURAL PREDOMINANCE, AS WELL AS THE EARLY INTEPSTITIAL INFILTRATION AND BRONCHIOLAR ABNORMALITIES IN COLLAGEN VASCULAR DISEASES. A PATTERN OF CRESCENTIC OPACITIES SURROUNDING AREAS OF GROUND GLASSDENSITIES IS POTENTIALLY SPECIFIC FOR DIAGNOSIS OF BOOP. CIRCUMFERENTIALLY DISTRIBUTED GROUNG-GLASS OPACITIES AROUND THE LUNGS ARE INDICATIVE OF CHRONIC EOSINOPHILIC PNEUMONIA. MULTIPLE CYSTS AND CAVITATED MICRONODULES ARE SPECIFIC HRCT FINDINGS FOR HISTIOCYTOSIS-X.

Subjects/Keywords: BRONCHIOLITIS OBLITERANS ORGANIZING PNEUMONIA (BOOP); COLLAGEN VASCURAL DISEASES; Diffuse interstitial lung diseases (DILD); High resolution computed tomography (HRCT); Idiopathic pulmonary fibrosis (IPF); LYMPHANGITIC CARCINOMATOSIS; PULMONARY HISTIOCYTOSIS-X; Sarcoidosis; ΑΠΟΦΡΑΚΤΙΚΗ ΒΡΟΓΧΙΟΛΙΤΙΣ ΜΕ ΟΡΓΑΝΟΥΜΕΝΗ ΠΝΕΥΜΟΝΙΑ; Διάχυτες διάμεσες πνευμονοπάθειες; Ιδιοπαθής πνευμονική ίνωση; ΚΟΛΛΑΓΟΝΟΠΑΘΕΙΕΣ; ΛΕΜΦΑΓΓΕΙΑΚΗ ΚΑΡΚΙΝΩΜΑΤΩΣΗ; ΠΝΕΥΜΟΝΙΚΗ ΙΣΤΙΟΚΥΤΤΑΡΩΣΗ-Χ; Σαρκοείδωση; ΥΠΟΛΟΓΙΣΤΙΚΗ ΤΟΜΟΓΡΑΦΙΑ ΥΨΗΛΗΣ ΕΥΚΡΙΝΕΙΑΣ

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

ΒΟΛΟΥΔΑΚΗ, �. (1996). ΜΕΛΕΤΗ ΔΙΑΧΥΤΩΝ ΔΙΑΜΕΣΩΝ ΠΝΕΥΜΟΝΟΠΑΘΕΙΩΝ. ΑΞΙΟΛΟΓΗΣΗ ΜΕ ΥΠΟΛΟΓΙΣΤΙΚΗ ΤΟΜΟΓΡΑΦΙΑΥΨΗΛΗΣ ΕΥΚΡΙΝΕΙΑΣ. (Thesis). Πανεπιστήμιο Κρήτης; University of Crete (UOC). Retrieved from http://hdl.handle.net/10442/hedi/7421

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

ΒΟΛΟΥΔΑΚΗ, ΑΡΓΥΡΩ. “ΜΕΛΕΤΗ ΔΙΑΧΥΤΩΝ ΔΙΑΜΕΣΩΝ ΠΝΕΥΜΟΝΟΠΑΘΕΙΩΝ. ΑΞΙΟΛΟΓΗΣΗ ΜΕ ΥΠΟΛΟΓΙΣΤΙΚΗ ΤΟΜΟΓΡΑΦΙΑΥΨΗΛΗΣ ΕΥΚΡΙΝΕΙΑΣ.” 1996. Thesis, Πανεπιστήμιο Κρήτης; University of Crete (UOC). Accessed February 28, 2021. http://hdl.handle.net/10442/hedi/7421.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

ΒΟΛΟΥΔΑΚΗ, ΑΡΓΥΡΩ. “ΜΕΛΕΤΗ ΔΙΑΧΥΤΩΝ ΔΙΑΜΕΣΩΝ ΠΝΕΥΜΟΝΟΠΑΘΕΙΩΝ. ΑΞΙΟΛΟΓΗΣΗ ΜΕ ΥΠΟΛΟΓΙΣΤΙΚΗ ΤΟΜΟΓΡΑΦΙΑΥΨΗΛΗΣ ΕΥΚΡΙΝΕΙΑΣ.” 1996. Web. 28 Feb 2021.

Vancouver:

ΒΟΛΟΥΔΑΚΗ �. ΜΕΛΕΤΗ ΔΙΑΧΥΤΩΝ ΔΙΑΜΕΣΩΝ ΠΝΕΥΜΟΝΟΠΑΘΕΙΩΝ. ΑΞΙΟΛΟΓΗΣΗ ΜΕ ΥΠΟΛΟΓΙΣΤΙΚΗ ΤΟΜΟΓΡΑΦΙΑΥΨΗΛΗΣ ΕΥΚΡΙΝΕΙΑΣ. [Internet] [Thesis]. Πανεπιστήμιο Κρήτης; University of Crete (UOC); 1996. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10442/hedi/7421.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ΒΟΛΟΥΔΑΚΗ �. ΜΕΛΕΤΗ ΔΙΑΧΥΤΩΝ ΔΙΑΜΕΣΩΝ ΠΝΕΥΜΟΝΟΠΑΘΕΙΩΝ. ΑΞΙΟΛΟΓΗΣΗ ΜΕ ΥΠΟΛΟΓΙΣΤΙΚΗ ΤΟΜΟΓΡΑΦΙΑΥΨΗΛΗΣ ΕΥΚΡΙΝΕΙΑΣ. [Thesis]. Πανεπιστήμιο Κρήτης; University of Crete (UOC); 1996. Available from: http://hdl.handle.net/10442/hedi/7421

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations