subject:(Breast Cancer)

Addis Ababa University

1. FETENE, KASAHUN AMOGNE. ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA .

Degree: 2014, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/5662

► Background: Breast cancer is a disease of public health importance. It results in high morbidity and mortality in women worldwide. Breast examination as a screening… (more)

▼ Background: Breast cancer is a disease of public health importance. It results in high morbidity and mortality in women worldwide. Breast examination as a screening tool for breast cancer in developing countries is advocated in view of its cost-effectiveness. Early detection of breast cancer using breast self-examination (BSE) plays an important role in decreasing its morbidity and mortality. Objective: To assess breast cancer awareness and practice of breast self-examination among female students in Madawalabu University Bale, Ethiopia, 2014 Methods: Cross-sectional study design was employed from December –June, 2014 in Madawalabu University. First the students were divided in to two practical strata, which are health science students and non-health science students. From each stratum, participants were selected by simple random sampling based on the proportion of the number of female students in each stratum that was 39 health science students and 383 non- health science students. Self administered questionnaire was used to collect the data. Data were entered with Epi Info version 3.5.1 and analyzed using SPSS statistical package version 16.0. Bivariate and multivariate logistic regression analysis was performed. Result: This study found that only [31.0%] of students had awareness about breast cancer and [15.5%] practiced BSE. The three main reasons for not doing BSE were belief that there is no problem with their breast [50.8%], not knowing the technique of BSE [40.0%], and Lack of privacy [15%]. Awareness about breast cancer and got information about BSE by health professionals were found significantly associated with practice of BSE. Respondents in the health related disciplines were six times more likely to practice BSE than other respondents. Conclusion: Awareness of breast cancer and BSE practice was found low in this study. Having information on the importance of BSE was predictor of BSE practice. Advisors/Committee Members: SR WORKINESH SINSHAW (BSc, RN, MSc) (advisor).

Subjects/Keywords: BREAST CANCER; BREAST

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APA (6^th Edition):

FETENE, K. A. (2014). ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5662

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

FETENE, KASAHUN AMOGNE. “ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA .” 2014. Thesis, Addis Ababa University. Accessed April 11, 2021. http://etd.aau.edu.et/dspace/handle/123456789/5662.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

FETENE, KASAHUN AMOGNE. “ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA .” 2014. Web. 11 Apr 2021.

Vancouver:

FETENE KA. ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA . [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Apr 11]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5662.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

FETENE KA. ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA . [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5662

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New Mexico

2. Smith, Randi L. Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.

Degree: Biomedical Sciences Graduate Program, 2015, University of New Mexico

URL: https://digitalrepository.unm.edu/biom_etds/93

► Our recent studies have shown that Tumor Adjacent Histologically Normal (TAHN) breast tissue demonstrates many of the characteristics of breast tumors. For example, through immunohistochemical… (more)

Subjects/Keywords: Cancer; Breast Cancer

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APA (6^th Edition):

Smith, R. L. (2015). Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. (Masters Thesis). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/93

Chicago Manual of Style (16^th Edition):

Smith, Randi L. “Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.” 2015. Masters Thesis, University of New Mexico. Accessed April 11, 2021. https://digitalrepository.unm.edu/biom_etds/93.

MLA Handbook (7^th Edition):

Smith, Randi L. “Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.” 2015. Web. 11 Apr 2021.

Vancouver:

Smith RL. Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. [Internet] [Masters thesis]. University of New Mexico; 2015. [cited 2021 Apr 11]. Available from: https://digitalrepository.unm.edu/biom_etds/93.

Council of Science Editors:

Smith RL. Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. [Masters Thesis]. University of New Mexico; 2015. Available from: https://digitalrepository.unm.edu/biom_etds/93

University of Alberta

3. Bernier, Ashlyn. Mechanisms of MUC1/ICAM-1 signalling in breast cancer metastasis.

Degree: PhD, Medical Sciences - Laboratory Medicine and Pathology, 2011, University of Alberta

URL: https://era.library.ualberta.ca/files/db78td08r

► Breast cancer is the second leading cause of cancer death in Canadian women. In these patients, mortality is due to metastasis of cancer cells from… (more)

▼ Breast cancer is the second leading cause of cancer death in Canadian women. In these patients, mortality is due to metastasis of cancer cells from the breast to distant organs, resulting in impairment of function. To metastasize, cells must move through the stroma of the breast, enter the circulation, survive transit, exit the circulation, and form a secondary tumor. A critical component of this metastatic cascade is cancer cell motility. It is not fully understood how breast cancer cells gain the ability to move or what signaling pathways mediate these events, and identification of critical components of these pathways would represent potential targets for anti-metastatic therapies. The MUC1 glycoprotein is expressed on the apical membrane of normal breast epithelia. In many human breast carcinomas, MUC1 is overexpressed and loses apical polarization, events that correlate with increased metastasis. The contribution of MUC1 overexpression to increased metastasis is not completely understood, with the majority of studies attributing an anti-adhesive role to MUC1. Several critical steps of the metastatic cascade require cell adhesion, and it has been reported that MUC1 is a ligand for ICAM-1, which is expressed throughout the migratory tract of a metastasizing breast cancer cell. It was subsequently reported that MUC1/ICAM-1 binding initiates calcium oscillations, cytoskeletal reorganization, and cell migration, suggesting that binding could be important in metastasis. Here, we investigate the mechanism of MUC1/ICAM-1 binding induced signaling. We show that Src kinase is a critical component of the MUC1/ICAM-1 signalling axis, and that MUC1 forms constitutive dimers which are required for Src recruitment and ICAM-1 binding induced signaling. We show that MUC1 dimers are not covalently linked and do not require cytoplasmic domain cysteine residues, contrary to other reports. We show that MUC1 extracellular domain shedding is not required for dimerization, Src recruitment, or ICAM-1 binding induced calcium oscillations, although it is required for migration. Lastly, we show that autoproteolytic cleavage of MUC1 is not required for normal function. These results reveal information on the mechanism of MUC1/ICAM-1 signalling, which can be used to identify novel targets and combinational strategies for anti-metastatic therapy in breast cancer.

Subjects/Keywords: Breast Cancer

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APA (6^th Edition):

Bernier, A. (2011). Mechanisms of MUC1/ICAM-1 signalling in breast cancer metastasis. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/db78td08r

Chicago Manual of Style (16^th Edition):

Bernier, Ashlyn. “Mechanisms of MUC1/ICAM-1 signalling in breast cancer metastasis.” 2011. Doctoral Dissertation, University of Alberta. Accessed April 11, 2021. https://era.library.ualberta.ca/files/db78td08r.

MLA Handbook (7^th Edition):

Bernier, Ashlyn. “Mechanisms of MUC1/ICAM-1 signalling in breast cancer metastasis.” 2011. Web. 11 Apr 2021.

Vancouver:

Bernier A. Mechanisms of MUC1/ICAM-1 signalling in breast cancer metastasis. [Internet] [Doctoral dissertation]. University of Alberta; 2011. [cited 2021 Apr 11]. Available from: https://era.library.ualberta.ca/files/db78td08r.

Council of Science Editors:

Bernier A. Mechanisms of MUC1/ICAM-1 signalling in breast cancer metastasis. [Doctoral Dissertation]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/db78td08r

4. Liu, Tianli. Long Term Health Outcomes of Prenatal Exposure to Cigarette Smoking.

Degree: PhD, Division of Biology and Medicine. Epidemiology, 2009, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:198/

► This dissertation focuses on the long term health outcomes of prenatal exposure to cigarette smoke. We hypothesize that exposure to toxins through maternal smoking could… (more)

▼ This dissertation focuses on the long term health outcomes of prenatal exposure to cigarette smoke. We hypothesize that exposure to toxins through maternal smoking could affect the hypothalamus of the fetal brain, subsequently leading to a long term impact on physical and mental health. Three epidemiologic studies were conducted to test this hypothesis. Study one is a prospective cohort study examining whether maternal smoking during pregnancy increased the risk of benign breast disease (BBD) among adult female offspring. The study results suggested that women whose mothers smoked during pregnancy were more than two times more likely to develop BBD in their adulthood than women whose mothers never smoked during pregnancy. We consider that the findings were consistent with our hypothesis. The hypothalamus is the control center of the brain for sex hormone release. A toxic influence on the hypothalamus might induce a sex hormone imbalance which subsequently leads to BBD. Study two further examined the relationship between postnatal smoking exposures and risk of BBD. None of these postnatal smoking exposures were found to be independently associated with the risk of BBD. These findings confirmed our hypothesis that exposure to cigarette smoking during the prenatal period, instead of the postnatal period, predicted an increased risk of BBD. The programming of the hypothalamus is taking place during the prenatal period, when the blood-brain barrier, which prevents the passage of many toxic agents into the brain, is not fully developed. We conclude that the prenatal period is a unique time during which toxic agents can impact the fetal brain. As the hypothalamus not only controls sex hormone balance, but also anger and rage, in study three, we examined the relationship between maternal smoking during pregnancy and anger temperament of the offspring using several sets of analyses. The results consistently showed that maternal smoking during pregnancy was associated with an increased level of anger temperament among adult offspring. We consider the results support our hypothesis. Prenatal exposure to cigarette smoking might have disturbed the normal development and organization of the hypothalamus, and in doing so, would have an impact on anger temperament. Advisors/Committee Members: Buka, Stephen (director), Gatsonis, Constantine (reader), Baylin, Ana (reader).

Subjects/Keywords: breast cancer

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APA (6^th Edition):

Liu, T. (2009). Long Term Health Outcomes of Prenatal Exposure to Cigarette Smoking. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:198/

Chicago Manual of Style (16^th Edition):

Liu, Tianli. “Long Term Health Outcomes of Prenatal Exposure to Cigarette Smoking.” 2009. Doctoral Dissertation, Brown University. Accessed April 11, 2021. https://repository.library.brown.edu/studio/item/bdr:198/.

MLA Handbook (7^th Edition):

Liu, Tianli. “Long Term Health Outcomes of Prenatal Exposure to Cigarette Smoking.” 2009. Web. 11 Apr 2021.

Vancouver:

Liu T. Long Term Health Outcomes of Prenatal Exposure to Cigarette Smoking. [Internet] [Doctoral dissertation]. Brown University; 2009. [cited 2021 Apr 11]. Available from: https://repository.library.brown.edu/studio/item/bdr:198/.

Council of Science Editors:

Liu T. Long Term Health Outcomes of Prenatal Exposure to Cigarette Smoking. [Doctoral Dissertation]. Brown University; 2009. Available from: https://repository.library.brown.edu/studio/item/bdr:198/

Addis Ababa University

5. DURETI, GENA. KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS .

Degree: 2013, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/7004

► Breast cancer is one of the most common cancers and a major cause of death among women worldwide. Each year, breast cancer is newly diagnosed… (more)

Subjects/Keywords: Breast cancer

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APA (6^th Edition):

DURETI, G. (2013). KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/7004

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DURETI, GENA. “KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS .” 2013. Thesis, Addis Ababa University. Accessed April 11, 2021. http://etd.aau.edu.et/dspace/handle/123456789/7004.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DURETI, GENA. “KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS .” 2013. Web. 11 Apr 2021.

Vancouver:

DURETI G. KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS . [Internet] [Thesis]. Addis Ababa University; 2013. [cited 2021 Apr 11]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/7004.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DURETI G. KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS . [Thesis]. Addis Ababa University; 2013. Available from: http://etd.aau.edu.et/dspace/handle/123456789/7004

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University

6. Dewi, Fitriya Nur Annisa. THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES.

Degree: 2013, Wake Forest University

URL: http://hdl.handle.net/10339/39018

► Diet has been thought to modify developmental regulation and subsequently influence later-life susceptibility to various diseases including cancer. Meta-analyses showed that the intake of soy,… (more)

▼ Diet has been thought to modify developmental regulation and subsequently influence later-life susceptibility to various diseases including cancer. Meta-analyses showed that the intake of soy, which contains the phytoestrogenic compounds isoflavones (IFs), is associated with reduced breast cancer risk. A similar relationship has been reported for soy and endometrial cancer, although the evidence is more limited. Interestingly, the inverse association between soy and breast cancer is more consistent when soy exposure occurs preceding puberty. Our primary aim was to investigate the effect of soy consumption beginning pre-adulthood on the breast and uterine tissues in relation to estrogen action. We utilized two animal models: cynomolgus macaques and apolipoprotein E-null mice. The macaque study longitudinally assessed tissue changes across pubertal development to model young girls consuming a North American diet with/without soy IF exposure. We found that soy intake did not alter pubertal growth, menarche, or uterine development. Soy exposure initiated at puberty promoted mammary gland differentiation which resulted in a breast composed of abundant mature lobular structures in adulthood, a phenotype consistent with low cancer risk. We observed a modestly lower expression of ERs and ER activity markers, suggesting that early soy exposure could potentially result in lower estrogen-responsiveness in the adult breast. These changes were not associated with differential circulating estradiol and progesterone, CpG methylation within the specific promoter regions examined, or expression of intramammary estrogen-metabolizing enzymes. To explain whether the soy effect is dependent on the primary IF metabolite equol, we conducted a study whereby mice were modified to have equol-producing vs. non-equol-producing capability to model the low frequency of equol production observed in human populations. Mice were fed dietary soy with/without exogenous equol starting at peripubertal age. Equol, but not a soy diet per se, modulated estrogen-dependent uterine responses; the effect was less clear in the breast. Female equol producers had lower estrogenic reproductive tissue phenotypes compared to nonproducers, regardless of IF dose. Collectively, our findings indicate that pubertal exposure to soy may have a subtle effect in promoting breast differentiation and downregulating estrogen-responsiveness. Equol and/or equol-producing microbiota may influence estrogen-associated tissue phenotype and response to soy diet.

Subjects/Keywords: Breast cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dewi, F. N. A. (2013). THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/39018

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dewi, Fitriya Nur Annisa. “THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES.” 2013. Thesis, Wake Forest University. Accessed April 11, 2021. http://hdl.handle.net/10339/39018.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dewi, Fitriya Nur Annisa. “THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES.” 2013. Web. 11 Apr 2021.

Vancouver:

Dewi FNA. THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10339/39018.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dewi FNA. THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/39018

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University

7. Liu, Yin. BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY.

Degree: 2018, Wake Forest University

URL: http://hdl.handle.net/10339/90710

► Breast cancer is one of major public health problem worldwide. However, the underlying molecular mechanism of breast cancer progression and metastasis is not well understood.… (more)

Subjects/Keywords: Breast cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, Y. (2018). BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/90710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Liu, Yin. “BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY.” 2018. Thesis, Wake Forest University. Accessed April 11, 2021. http://hdl.handle.net/10339/90710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Liu, Yin. “BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY.” 2018. Web. 11 Apr 2021.

Vancouver:

Liu Y. BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY. [Internet] [Thesis]. Wake Forest University; 2018. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10339/90710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Liu Y. BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY. [Thesis]. Wake Forest University; 2018. Available from: http://hdl.handle.net/10339/90710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

California State Polytechnic University – Pomona

8. Lolarga, Jade. A Study of the Regulation of Breast Cancer Cell Invasion.

Degree: MS, Department of Biological Sciences, 2020, California State Polytechnic University – Pomona

URL: http://hdl.handle.net/10211.3/216845

► Metastasis occurs when cancer cells spread from their primary site to other tissues in the body, which is the main cause of death in most… (more)

▼ Metastasis occurs when cancer cells spread from their primary site to other tissues in the body, which is the main cause of death in most cancer patients. Metastasis is a multistep process and the initial step is the invasion of cancer cells to neighboring tissues. It is therefore important to understand the molecular mechanism underlying the regulation of cell invasion. TWIST1 is a transcription factor that has been previously identified as a key regulator of metastasis. BMI1 is a transcription target of TWIST1 and a subunit of Polycomb Repressive Complex 1 (PRC1) that possesses E3 ubiquitinating ligase activity. By mono-ubiquitinating histone H2A at Lysine 119 (K119), PRC1 can cause gene silencing. Our preliminary data showed that BMI1 works downstream of TWIST1 in promoting breast cancer cell invasion. On the other hand, USP16 is a deubiquitinase and is able to remove the ubiquitin from K119 of histone H2A. Our previous data has shown that Polo-like kinase 1 (PLK1) phosphorylates and activates USP16. We hypothesized that the PLK1-USP16 -mediated deubiquitination of histone H2A could inhibit the invasion of breast cancer cells by antagonizing TWIST1-BMI1-mediated ubiquitination at the same residue (K119) of histone H2A. To study cancer cell invasion regulated by these two molecular pathways, we adopted and optimized a three-dimensional (3D) cell culture system to analyze the invasiveness of cancer cells. This newly developed 3D tumor spheroid invasion assay provides data that more closely represents the in vivo behavior of cancer cells and is therefore rapidly gaining popularity among cancer researchers. In this study, we investigated the invasion of breast cancer cells regulated by TWIST1-BMI1 and PLK1- USP16 pathways in the 3D setting. The results supported our hypothesis that TWIST1-BMI1 pathway promotes cancer cell invasion, whereas PLK1-USP16 pathway inhibits the invasion. Furthermore, we showed that a harmala alkaloid called harmine could induce the degradation of TWIST1 and therefore inhibit breast cancer cell invasion in a dose-dependent manner. These results help us to better understand the regulation of metastasis and may contribute to the development of novel approaches for the treatment of metastatic breast cancer. Advisors/Committee Members: Liu, Junjun (advisor), Adler-Moore, Jill (committee member).

Subjects/Keywords: breast cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lolarga, J. (2020). A Study of the Regulation of Breast Cancer Cell Invasion. (Masters Thesis). California State Polytechnic University – Pomona. Retrieved from http://hdl.handle.net/10211.3/216845

Chicago Manual of Style (16^th Edition):

Lolarga, Jade. “A Study of the Regulation of Breast Cancer Cell Invasion.” 2020. Masters Thesis, California State Polytechnic University – Pomona. Accessed April 11, 2021. http://hdl.handle.net/10211.3/216845.

MLA Handbook (7^th Edition):

Lolarga, Jade. “A Study of the Regulation of Breast Cancer Cell Invasion.” 2020. Web. 11 Apr 2021.

Vancouver:

Lolarga J. A Study of the Regulation of Breast Cancer Cell Invasion. [Internet] [Masters thesis]. California State Polytechnic University – Pomona; 2020. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10211.3/216845.

Council of Science Editors:

Lolarga J. A Study of the Regulation of Breast Cancer Cell Invasion. [Masters Thesis]. California State Polytechnic University – Pomona; 2020. Available from: http://hdl.handle.net/10211.3/216845

Harvard University

9. Natsuhara, Kelsey H. Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria.

Degree: Doctor of Medicine, 2018, Harvard University

URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973486

►

Purpose: For clinically appropriate early-stage breast cancer patients, reflex criteria for Oncotype DX ordering (“the intervention”) was implemented at our comprehensive cancer center, which reduced… (more)

Subjects/Keywords: breast cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Natsuhara, K. H. (2018). Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973486

Chicago Manual of Style (16^th Edition):

Natsuhara, Kelsey H. “Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria.” 2018. Doctoral Dissertation, Harvard University. Accessed April 11, 2021. http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973486.

MLA Handbook (7^th Edition):

Natsuhara, Kelsey H. “Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria.” 2018. Web. 11 Apr 2021.

Vancouver:

Natsuhara KH. Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria. [Internet] [Doctoral dissertation]. Harvard University; 2018. [cited 2021 Apr 11]. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973486.

Council of Science Editors:

Natsuhara KH. Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria. [Doctoral Dissertation]. Harvard University; 2018. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973486

California State Polytechnic University – Pomona

10. Lam, Brandon. Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion.

Degree: MS, Department of Biological Sciences, 2020, California State Polytechnic University – Pomona

URL: http://hdl.handle.net/10211.3/214977

► Breast cancer is the most common non-skin cancer among American women. Comparing with early stage breast cancer, Stage IV or metastatic breast cancer has much… (more)

▼ Breast cancer is the most common non-skin cancer among American women. Comparing with early stage breast cancer, Stage IV or metastatic breast cancer has much lower 5 year survival rate (22%) and is a major threat to women???s health. The metastatic process originates at the primary tumor and causes secondary tumors at distant places, which can eventually lead to death. In breast cancer, the transition from an in situ tumor to a metastatic one occurs with a process called Epithelial-Mesenchymal Transition (EMT). EMT hallmarks of carcinoma cells include self-renewal, cell proliferation, increased cell invasion, and resistance to chemotherapeutics. One of the key proteins regulating this process is the transcription factor Twist1. Elevated expression of Twist1 has been found in highly invasive head-and-neck, lung, colorectal, and breast cancers, and likewise indicates poor prognosis for patients. Bmi1 is a downstream transcription target of Twist1. It interacts with Ring 1b to form part of an ubiquitinating complex called PRC1, which is responsible for chromatin remodeling and epigenetically regulating cell proliferation, self-renewal and ???stem-like??? properties. However, the processes regulating Bmi1 and Ring1b interaction and thus PRC1 activity are not well understood. In our previous studies, we have found that Twist1-Bmi1 pathway promotes breast cancer cell invasion. Recently, it was reported that a novel drug harmine could inhibit Twist1 and reduce the invasiveness of lung cancer cells. This leads us to hypothesize that harmine could also inhibit breast cancer cell invasion by targeting Twist1 in a dose dependent manner. Our results have confirmed this hypothesis. Furthermore, we have shown that the inhibition on breast cancer cell invasion is achieved by inducing proteasome-mediated Twist1 degradation. Meanwhile, we show that Bmi1 phosphorylation is cell cycle regulated. In M phase, Bmi1 is hyperphosphorylated, which is likely to disrupt its interaction with Ring1b leading to inactivation of PRC1; whereas in interphase, the hypophosphorylation of Bmi1 promotes Bmi1-Ring1b interaction and therefore the activation of PRC1, which ultimately leads to cancer cell invasion. Future work includes the identification of upstream kinase that phosphorylates Bmi1, and verification of harmine-induced inhibition on cancer cell invasion in vivo. In conclusion, targeting Twist1 and its downstream proteins such as Bmi1 could provide novel approaches for the treatment of metastatic breast cancer. Advisors/Committee Members: Liu, Junjun (advisor), Lin, Wei-Jen (committee member).

Subjects/Keywords: breast cancer

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APA (6^th Edition):

Lam, B. (2020). Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion. (Masters Thesis). California State Polytechnic University – Pomona. Retrieved from http://hdl.handle.net/10211.3/214977

Chicago Manual of Style (16^th Edition):

Lam, Brandon. “Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion.” 2020. Masters Thesis, California State Polytechnic University – Pomona. Accessed April 11, 2021. http://hdl.handle.net/10211.3/214977.

MLA Handbook (7^th Edition):

Lam, Brandon. “Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion.” 2020. Web. 11 Apr 2021.

Vancouver:

Lam B. Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion. [Internet] [Masters thesis]. California State Polytechnic University – Pomona; 2020. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10211.3/214977.

Council of Science Editors:

Lam B. Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion. [Masters Thesis]. California State Polytechnic University – Pomona; 2020. Available from: http://hdl.handle.net/10211.3/214977

University of Melbourne

11. Sawyer, Sarah Dilys. A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families.

Degree: 2014, University of Melbourne

URL: http://hdl.handle.net/11343/55238

► Breast cancer remains a significant health issue with the highest incidence and the second highest cause of cancer-related mortality amongst women worldwide. A family history… (more)

▼ Breast cancer remains a significant health issue with the highest incidence and the second highest cause of cancer-related mortality amongst women worldwide. A family history is an important risk factor, with women found to be twice as likely to develop the disease if they have one first-degree relative affected with breast cancer. It is the role of familial cancer clinics (FCCs) and genetic testing services to identify ‘high-risk’ individuals and offer genetic testing to eligible individuals looking for mutations within high-penetrance genes, such as BRCA1 and BRCA2. For mutation carriers, cancer risk assessment and management is based on a well-established foundation of evidence. However, up to 80% of individuals have no identifiable BRCA mutation, resulting in risk assessment and management advice that is based only on family history and is no longer personalised but instead directed by summary data from epidemiological studies of the general population. Researchers have continued the search for the other genetic causes of the heritable fraction of breast cancer through large, collaborative genome-wide association studies (GWAS). To date, these studies have identified over 70 common variants associated with breast cancer risk. Individually, the associations for these variants are too weak to be useful (relative risk <1.5), however, when the risks for these variants are combined multiplicatively (termed polygenic risk) the risk becomes more appreciable. It is estimated that up to 28% of familial breast cancer risk can be explained by common variants. Despite this, genetic testing for common genomic variants has yet to be implemented into routine clinical practice. This study explores the clinical significance and implications of common genomic variants to the assessment and risk management of high-risk breast and ovarian cancer families, to generate the data required to facilitate the translation of common variant genetic testing into clinical practice. To conduct this research, the study utilised the Victorian Familial Breast and Ovarian Cancer Cohort (VFBOCC) which consists of individuals (female index cases) who have been assessed as high-risk for breast and/or ovarian cancer based on their personal and family history of cancer. In Chapter 3, the development of a database that systematically incorporated and allowed for the well-defined characterisation of the VFBOCC is discussed. This database framework facilitated a detailed analysis of the cohort; it identified that females in this cohort have an average breast cancer age of onset of 44.9 years, which is much lower than the average age of onset observed in the general population, and that only 22% of the VFBOCC had a BRCA1 or BRCA2 mutation identified by diagnostic genetic testing. The establishment of this database enabled the VFBOCC data to be utilised in common genomic variant research as part of this thesis as well as within several collaborations which are also investigating the potential role of recently discovered rare genetic variations to…

Subjects/Keywords: breast cancer

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APA (6^th Edition):

Sawyer, S. D. (2014). A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/55238

Chicago Manual of Style (16^th Edition):

Sawyer, Sarah Dilys. “A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families.” 2014. Doctoral Dissertation, University of Melbourne. Accessed April 11, 2021. http://hdl.handle.net/11343/55238.

MLA Handbook (7^th Edition):

Sawyer, Sarah Dilys. “A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families.” 2014. Web. 11 Apr 2021.

Vancouver:

Sawyer SD. A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families. [Internet] [Doctoral dissertation]. University of Melbourne; 2014. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/11343/55238.

Council of Science Editors:

Sawyer SD. A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families. [Doctoral Dissertation]. University of Melbourne; 2014. Available from: http://hdl.handle.net/11343/55238

University of Hawaii – Manoa

12. Higa, Jason Kenji. Inflammation and breast cancer prevention by phyllostachys edulis extract.

Degree: 2016, University of Hawaii – Manoa

URL: http://hdl.handle.net/10125/102030

►

Ph.D. University of Hawaii at Manoa 2013.

Obesity affects roughly one-third of American adults, in which chronic inflammation and lipotoxicity are disorders that are frequently… (more)

▼

Ph.D. University of Hawaii at Manoa 2013.

Obesity affects roughly one-third of American adults, in which chronic inflammation and lipotoxicity are disorders that are frequently found in conjunction. An estimated 232,340 American women are predicted to be diagnosed with breast cancer (BrCa) in 2013, and 39,620 are expected to die from it. Obesity does not guarantee that a woman will develop BrCa, but it increases her risk of developing it. This dissertation focuses on the potential therapeutic effects of an extract from the bamboo Phyllostachys edulis as related to lipotoxicity-induced inflammation and breast cancer. Bamboo extract (BEX) has previously demonstrated anti-lipotoxic effects. In the present study, which used in vitro cell culture models mimicking lipotoxic conditions, BEX was found to decrease production of the inflammatory cytokines IL-6 and MCP-1, inhibit nuclear translocation of the proinflammatory transcription factors NF-κB and AP-1, and increase activity of the antiinflammatory transcription factors Nrf2 and PPARγ. An in vivo study showed that BEX could also inhibit MCP-1 production in mice when supplemented into a high fat diet. Tricin and 7-O-methyl tricin (7MT) were isolated from BEX, and both compounds had inhibitory effects on lipotoxicity-induced MCP-1 production. On the topic of breast cancer, BEX showed inhibitory effects on multiple BrCa cell lines while showing minimal toxicity to MCF-10A, a non-carcinoma mammary cell line. BEX appeared to induce protective effects in MCF-10A cells by increasing expression of genes involved with DNA damage and repair and inducing antioxidant signaling and activity. BrCa cell lines showed varied responses to inhibition by tricin, 7MT, and other compounds reportedly isolated from P. edulis. BEX did not bind to or activate estrogen receptor alpha at physiological levels. A proteomics study carried out on MCF7 cells treated with BEX, tricin, and 7MT suggested that BEX and its compounds may alter cytoskeletal structures, and inhibit mTOR and IGF-1R signaling.

Subjects/Keywords: breast cancer

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APA (6^th Edition):

Higa, J. K. (2016). Inflammation and breast cancer prevention by phyllostachys edulis extract. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/102030

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Higa, Jason Kenji. “Inflammation and breast cancer prevention by phyllostachys edulis extract.” 2016. Thesis, University of Hawaii – Manoa. Accessed April 11, 2021. http://hdl.handle.net/10125/102030.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Higa, Jason Kenji. “Inflammation and breast cancer prevention by phyllostachys edulis extract.” 2016. Web. 11 Apr 2021.

Vancouver:

Higa JK. Inflammation and breast cancer prevention by phyllostachys edulis extract. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10125/102030.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Higa JK. Inflammation and breast cancer prevention by phyllostachys edulis extract. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/102030

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

13. Estrella, Brian, 1989-. Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene.

Degree: PhD, Toxicology, 2018, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/57543/

► Fry is an evolutionarily-conserved gene involved in cellular differentiation, division, morphology, polarity, and adhesion. Decreased expression of the FRY protein in breast cancer cell lines… (more)

▼ Fry is an evolutionarily-conserved gene involved in cellular differentiation, division, morphology, polarity, and adhesion. Decreased expression of the FRY protein in breast cancer cell lines reduced the expression of gene networks associated with epithelial differentiation, morphology, polarity and adhesion. Ectopic expression of the wild-type rat Fry gene in human breast cancer cells restored a gene expression profile associated with differentiation, suppression of epithelial-mesenchymal transition. Breast cancer cells expressing wild-type Fry at physiological levels reacquired a non-transformed morphology in vitro and a non-tumorigenic in vivo phenotype in the nude mouse xenograft model. We further determined that expression of FRY mRNA and protein correlated with breast cancer phenotypes such as Elston tumor grade, estrogen receptor, progesterone receptor, and Her2 receptor status. Despite these finding, significant gaps in knowledge remain in our understanding of how FRY expression is decreased during tumor progression. Based on preliminary data, we hypothesized modulation of FRY expression occurs through epigenetic mechanisms which include DNA methylation, histone modification and chromatin remodeling, and the activity/interaction of non-coding RNAs. To understand how DNA methylation regulates FRY transcription in breast tumors, we examined publicly available RNA-seq and DNA methylation data from The Cancer Genome Atlas (TCGA). Analysis of FRY promoter methylation revealed no significant changes in DNA methylation in normal vs. breast tumors. However, when we subdivided the tumors by hormone receptor status, we observed an increase in FRY promoter methylation in ER- and PR- breast tumors. Treatment of various breast cancer cell lines with the DNMT inhibitor, 5-Aza-2-deoxycytidine, resulted in upregulation of FRY mRNA and protein expression. These results indicate that loss of FRY expression may in part be due to increased methylation. To elucidate the role of chromatin in the role of FRY expression we searched publicly available chromatin immunoprecipitation sequencing data from the Encyclopedia of DNA elements (ENCODE) to identify key chromatin markers and transcription factors that bind to the FRY promoter. Using this data, we demonstrated that FRY has a canonical gene promoter characterized by low levels of H3K4me1 and high levels H3K4me2/me3. Furthermore, using data from the ENCODE, we identified 28 transcription factors predicted to binds to the FRY gene promoter, the most significant of which were estrogen receptor 1 (ESR1) and progesterone receptor (PR). To determine if histone deacteylases (HDACs) impacted FRY expression, we dosed various breast cancer cell lines with commonly used the HDAC inhibitors, Trichostatin-A and Panobinostat (LBH589). Through treatment of our cell lines with these HDAC inhibitors, we were able to modulate FRY expression, indicating that its expression is in part regulated by protein acetylation. Next, we explored whether transcriptional repressor, enhancer of Zeste Homolog 2… Advisors/Committee Members: Zarbl, Helmut (chair), School of Graduate Studies.

Subjects/Keywords: Breast – Cancer

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APA (6^th Edition):

Estrella, Brian, 1. (2018). Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/57543/

Chicago Manual of Style (16^th Edition):

Estrella, Brian, 1989-. “Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene.” 2018. Doctoral Dissertation, Rutgers University. Accessed April 11, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/57543/.

MLA Handbook (7^th Edition):

Estrella, Brian, 1989-. “Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene.” 2018. Web. 11 Apr 2021.

Vancouver:

Estrella, Brian 1. Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Apr 11]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57543/.

Council of Science Editors:

Estrella, Brian 1. Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57543/

Rutgers University

14. Hemler, Jennifer R., 1972-. Life with, after, or beyond cancer: breast cancer survivorship and the new normal.

Degree: PhD, Sociology, 2015, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/

►

I examine how women “move on,” or are unable to, after a diagnosis of breast cancer. I interviewed 80 survivors of various types and stages… (more)

▼

I examine how women “move on,” or are unable to, after a diagnosis of breast cancer. I interviewed 80 survivors of various types and stages of breast cancer to explore the relationship between how breast cancer survivors think about cancer and how they manage the daily consequences of this disease, including its effects on identity. My main objective was to examine the cognitive strategies and social practices survivors employ for living with (a history of having had) cancer. Cancer experience is undoubtedly shaped by factors like disease stage and type, treatments received, time since diagnosis and treatment, age, and social location. But many of my participants, across categories, described bracketing some aspects of their experience while holding onto a certain degree of ontological insecurity as they redefined their lives after, with, or beyond cancer. Drawing on ontological insecurity enabled them to remain attuned to their selves: they used cancer to help them redraw boundaries in their lives and focus attention on their selves in ways they were not doing previously. While self-regulatory health practices, feminist ideologies/the women’s health movement, and environmental awareness overlap in breast cancer survivorship to produce activated patients and actualized subjectivities, my participants also discussed how the existential and medical uncertainties of their experiences led them to create new spaces for meaning in their lives. However, while many of my participants wanted to use cancer as a catalyst for self-growth or change across life domains, certainly not all of them were able to do so. Survivorship programs are critical in this regard. They can help survivors harness the uncertainty they feel instead of allowing it to become paralyzing or debilitating. Many survivors need help framing ontological insecurity as a resource to employ, not something to move beyond; but, moreover, they need spaces in which they can acknowledge these uncertainties as part of their new realities.

Advisors/Committee Members: Cerulo, Karen A (chair), Carr, Deborah (internal member), Horwitz, Allan (internal member), Almeling, Rene (outside member).

Subjects/Keywords: Breast – Cancer; Breast cancer patients; Cancer – Patients

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hemler, Jennifer R., 1. (2015). Life with, after, or beyond cancer: breast cancer survivorship and the new normal. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48509/

Chicago Manual of Style (16^th Edition):

Hemler, Jennifer R., 1972-. “Life with, after, or beyond cancer: breast cancer survivorship and the new normal.” 2015. Doctoral Dissertation, Rutgers University. Accessed April 11, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/48509/.

MLA Handbook (7^th Edition):

Hemler, Jennifer R., 1972-. “Life with, after, or beyond cancer: breast cancer survivorship and the new normal.” 2015. Web. 11 Apr 2021.

Vancouver:

Hemler, Jennifer R. 1. Life with, after, or beyond cancer: breast cancer survivorship and the new normal. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Apr 11]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/.

Council of Science Editors:

Hemler, Jennifer R. 1. Life with, after, or beyond cancer: breast cancer survivorship and the new normal. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/

15. Mukupo, Florence C. Breast self examination practices among rural (Solwezi) and urban (Lusaka) women.

Degree: 2012, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/1445

► Breast cancer is a significant health threat for women and is currently the second- leading cause of cancer related deaths in women. Breast cancer is… (more)

▼ Breast cancer is a significant health threat for women and is currently the second- leading cause of cancer related deaths in women. Breast cancer is the second most common cancer of women in Zambia. Breast cancer screening has been shown to reduce mortality. Thus early detection is crucial. World Health Organization does not recommend mammography screening in developing countries because it is not cost effective. Breast Self Examination (BSE) is an alternative method of screening for breast cancer. BSE is recommended for all women over the age of 20. Despite this recommendation, adherence to BSE guidelines is quite low. Study Design The purpose of the current study was to compare knowledge and use of BSE among rural and urban women. The study also sought to detect associations between the study variables. Study Setting The study was conducted in Solwezi and Lusaka Districts. Sampling Simple random sampling was utilized to select the wards were the research was conducted. The using systematic sampling, households were selected. Then all women in childbearing age who met the inclusion criteria were interviewed. The age range was 15-49years because cancer of the breast has a high prevalence in this age group. A total of 238 respondents took part in the study. Instrument Data was collected using an interview schedule. Analysis Data analysis was done using EPI info statistical package. Results:The study showed that most of the respondents, 58.2% from urban area and 81.9% from rural area had no knowledge on breast cancer. The study also showed that BSE knowledge was low among the respondents. The majority of the respondents 84.5% in rural and 64.7% from urban area had no knowledge on BSE.BSE practice results showed that the majority of the respondents were not practicing BSE. The study concluded that both the knowledge and practice of BSE were low in both rural and urban areas.The study recommended that Primary health care workers should be trained to teach Breast self-examination (BSE). The MoH/CBoH should develop teaching manuals for use by health providers during BSE teaching so that there is consistence and uniformity in BSE information to the women. The MoH/CBoH should ensure that nurses' knowledge and skill in BSE should be improved through re-training so that they could give expert instructions to women in relation to BSE technique. Breast Awareness, which is advocated in place of routine breast examination, should be encouraged among women. Health providers should continue to initiate discussions on BSE and the importance of periodic check up that include Clinical Breast Examination (CBE) for all women.Women should be taught to request for CBE even if their initial visit has nothing to do with clinical breast examination. Nurses teaching BSE must emphasize that early detection and treatment enhances survival. School Health Programs should include health education on breast cancer and BSE so that these educational programs on BSE start as early as 12 years of age, so that the girl child could start BSE early and…

Subjects/Keywords: Breast – Examination; Breast – Cancer – Zambia

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APA (6^th Edition):

Mukupo, F. C. (2012). Breast self examination practices among rural (Solwezi) and urban (Lusaka) women. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/1445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mukupo, Florence C. “Breast self examination practices among rural (Solwezi) and urban (Lusaka) women.” 2012. Thesis, University of Zimbabwe. Accessed April 11, 2021. http://dspace.unza.zm/handle/123456789/1445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mukupo, Florence C. “Breast self examination practices among rural (Solwezi) and urban (Lusaka) women.” 2012. Web. 11 Apr 2021.

Vancouver:

Mukupo FC. Breast self examination practices among rural (Solwezi) and urban (Lusaka) women. [Internet] [Thesis]. University of Zimbabwe; 2012. [cited 2021 Apr 11]. Available from: http://dspace.unza.zm/handle/123456789/1445.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mukupo FC. Breast self examination practices among rural (Solwezi) and urban (Lusaka) women. [Thesis]. University of Zimbabwe; 2012. Available from: http://dspace.unza.zm/handle/123456789/1445

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California

16. Liu, Chia-Wei. Factors influencing the decision and timing to undergo breast reconstruction after mastectomy for breast cancer in public hospital vs. private medical center from 2007 to 2013: a retrospective cohort study.

Degree: MS, Biostatistics, 2015, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/553067/rec/2735

► Background/Objective: This study was performed to compare the rates of breast reconstruction between a public safety‐net hospital (LA County Medical Center (LAC)) vs. a academic… (more)

▼ Background/Objective: This study was performed to compare the rates of breast reconstruction between a public safety‐net hospital (LA County Medical Center (LAC)) vs. a academic medical center (Keck Hospital of USC/Norris Cancer Center (Keck/Norris)), with emphasis on immediate breast reconstruction (IBR). We hypothesized that both overall reconstruction rate (the proportion of patients receiving reconstruction among the total patients having mastectomy) and the IBR rate (the proportion of patients receiving IBR among the total patients having reconstruction) were higher at Keck/Norris than LAC. We also aimed to explore the factors that were associated with overall reconstruction rate or IBR rate, and to estimate the time to reconstruction and the fraction of patients who would not undergo delayed breast reconstruction (cure fraction). ❧ Methods: We retrospectively collected all the data of patients with stage 0 – III breast cancer who received mastectomy during Jan 2006 to Dec 2013 from Keck/Norris and LAC. Univariate and multivariate logistic regressions were performed to compare the IBR rate and overall reconstruction rate between the two institutions, as well as to evaluate the correlation between IBR rate or overall reconstruction rate with various factors. Kaplan‐Meier method was used to scrutinize the time to reconstruction, and non‐mixture cure fraction model was performed for estimating the cure fraction. ❧ Results: Of the 453 patients, 327 patients were from LAC and 126 were from Keck/Norris. The odds ratio (OR) of reconstruction rate was 2.2 at Keck/Norris compared to LAC (p < 0.001) without adjustment for patient demographic factors, but was no longer significant with adjustment. The OR of IBR rate was 21.2 compared from Keck/Norris to LAC (p < 0.001) without adjustment for patient demographic factors, and was 22.3 with adjustment (p < 0.001). Based on the p < 0.25 entry criteria, factors that we kept in the multivariate overall reconstruction rate model were insurance status (p < 0.001), race (p < 0.05), age (p < 0.001), BMI (p < 0.05), smoking status (p = 0.08), occupation status (p = 0.18), personal history of other cancer (p = 0.12), progesterone receptor (PR) status (p = 0.22) and radiotherapy (p < 0.001). For IBR rate we had institution (p < 0.001), BMI (p = 0.21), clinical stage (p < 0.01) and radiotherapy (p < 0.01) in the model. The Kaplan‐Meier curves revealed that more patients underwent IBR at Keck/Norris than at LAC. Excluding the IBR patients, the average time to reconstruction at Keck/Norris was 20.3 ± 0.47 (SE) months, and was 37.4 ± 0.91 (SE) months at LAC. The estimated cure fractions were 0.71 and 0.99 at LAC and Keck/Norris, respectively. The factors that we kept in the multivariate non‐mixture cure fraction model were institution (p < 0.01), insurance status (p < 0.05), age = (p < 0.001), smoking status (p = 0.10), occupation status (p = 0.062), clinical stage (p = 0.12), PR status (p < 0.05). ❧ Conclusions: The reconstruction rate did not differ between these two institutions, but… Advisors/Committee Members: Sposto, Richard (Committee Chair), Mack, Wendy Jean (Committee Member), Groshen, Susan L. (Committee Member).

Subjects/Keywords: breast cancer; mastectomy; breast reconstruction

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, C. (2015). Factors influencing the decision and timing to undergo breast reconstruction after mastectomy for breast cancer in public hospital vs. private medical center from 2007 to 2013: a retrospective cohort study. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/553067/rec/2735

Chicago Manual of Style (16^th Edition):

Liu, Chia-Wei. “Factors influencing the decision and timing to undergo breast reconstruction after mastectomy for breast cancer in public hospital vs. private medical center from 2007 to 2013: a retrospective cohort study.” 2015. Masters Thesis, University of Southern California. Accessed April 11, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/553067/rec/2735.

MLA Handbook (7^th Edition):

Liu, Chia-Wei. “Factors influencing the decision and timing to undergo breast reconstruction after mastectomy for breast cancer in public hospital vs. private medical center from 2007 to 2013: a retrospective cohort study.” 2015. Web. 11 Apr 2021.

Vancouver:

Liu C. Factors influencing the decision and timing to undergo breast reconstruction after mastectomy for breast cancer in public hospital vs. private medical center from 2007 to 2013: a retrospective cohort study. [Internet] [Masters thesis]. University of Southern California; 2015. [cited 2021 Apr 11]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/553067/rec/2735.

Council of Science Editors:

Liu C. Factors influencing the decision and timing to undergo breast reconstruction after mastectomy for breast cancer in public hospital vs. private medical center from 2007 to 2013: a retrospective cohort study. [Masters Thesis]. University of Southern California; 2015. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/553067/rec/2735

University of New South Wales

17. Kalyuga , Maria. Exploration of the role of the ETS transcription factor ESE2 in breast cancer.

Degree: Clinical School - St Vincent's Hospital, 2011, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/51251 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9903/SOURCE02?view=true

► Thesis abstract: Breast cancer represents a leading cancer-related diagnosis of Australian women, with treatments ultimately still ineffective for many patients. Investigating the mechanisms behind normal… (more)

▼ Thesis abstract: Breast cancer represents a leading cancer-related diagnosis of Australian women, with treatments ultimately still ineffective for many patients. Investigating the mechanisms behind normal breast development is a means to identify processes involved in carcinogenesis, as they are frequently corrupted to facilitate tumour initiation and progression. The PRL signaling pathway is vital for the function of the mammary tissue during pregnancy and lactation. The mouse ELF5 and its human counterpart, ESE2, were identified as downstream targets of this pathway and have subsequently been characterised as crucial players in mammary gland development. In addition, limited evidence has pointed to the possibility of this protein being involved in human breast carcinogenesis, although a direct link remains pending. The current body of work was aimed at exploring the role of the human ESE2 in breast cancer. This was achieved through the use of a range of large and small-scale in vitro techniques to, firstly, attempt to identify potential ESE2 binding partners. Secondly, a model of inducible, stable ESE2 downregulation was employed to establish the function of ESE2 in the T47D breast cancer cell line, in the context of progesterone signaling, which is an important mediator of normal and aberrant mammary gland behaviour. It was determined that inhibiting a progestin-mediated ESE2 increase led to the augmentation of the previously characterised anti-proliferative effects of this hormone. An equivalent overexpression model was generated and characterised in detail. Negative effects of ESE2 on cell proliferation and adhesion were identified and were accompanied by changes at the level of apoptosis, gene transcription activity and other molecular changes. The data gathered is the first study to directly examine the role of ESE2 in human breast cancer. Advisors/Committee Members: Ormandy, Christopher , Clinical School - St Vincent's Hospital, Faculty of Medicine, UNSW.

Subjects/Keywords: Breast cancer; Human breast carcinogenesis

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APA (6^th Edition):

Kalyuga , M. (2011). Exploration of the role of the ETS transcription factor ESE2 in breast cancer. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/51251 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9903/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Kalyuga , Maria. “Exploration of the role of the ETS transcription factor ESE2 in breast cancer.” 2011. Doctoral Dissertation, University of New South Wales. Accessed April 11, 2021. http://handle.unsw.edu.au/1959.4/51251 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9903/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Kalyuga , Maria. “Exploration of the role of the ETS transcription factor ESE2 in breast cancer.” 2011. Web. 11 Apr 2021.

Vancouver:

Kalyuga M. Exploration of the role of the ETS transcription factor ESE2 in breast cancer. [Internet] [Doctoral dissertation]. University of New South Wales; 2011. [cited 2021 Apr 11]. Available from: http://handle.unsw.edu.au/1959.4/51251 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9903/SOURCE02?view=true.

Council of Science Editors:

Kalyuga M. Exploration of the role of the ETS transcription factor ESE2 in breast cancer. [Doctoral Dissertation]. University of New South Wales; 2011. Available from: http://handle.unsw.edu.au/1959.4/51251 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9903/SOURCE02?view=true

Delft University of Technology

18. Janssen, Ernest (author). Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system.

Degree: 2019, Delft University of Technology

URL: http://resolver.tudelft.nl/uuid:32ca7acd-c89c-43b6-8576-2d5181995d50

►

Breast cancer is impacting over 1.5 million women each year. Early detection is essential in decreasing the mortality rate. Mammography is currently the golden standard… (more)

Subjects/Keywords: Breast cancer; Ultrasound; Breast scanning

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APA (6^th Edition):

Janssen, E. (. (2019). Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:32ca7acd-c89c-43b6-8576-2d5181995d50

Chicago Manual of Style (16^th Edition):

Janssen, Ernest (author). “Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system.” 2019. Masters Thesis, Delft University of Technology. Accessed April 11, 2021. http://resolver.tudelft.nl/uuid:32ca7acd-c89c-43b6-8576-2d5181995d50.

MLA Handbook (7^th Edition):

Janssen, Ernest (author). “Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system.” 2019. Web. 11 Apr 2021.

Vancouver:

Janssen E(. Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Apr 11]. Available from: http://resolver.tudelft.nl/uuid:32ca7acd-c89c-43b6-8576-2d5181995d50.

Council of Science Editors:

Janssen E(. Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:32ca7acd-c89c-43b6-8576-2d5181995d50

Oregon State University

19. Everson, Courtney Louise. Reproductive decision-making in young women breast cancer survivors.

Degree: MA, Applied Anthropology, 2009, Oregon State University

URL: http://hdl.handle.net/1957/10010

► The purpose of this study is to use an integrated biocultural perspective to examine the decision-making processes of young survivors as they navigate breast cancer… (more)

Subjects/Keywords: breast cancer; Breast – Cancer – Patients – Decision making

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APA (6^th Edition):

Everson, C. L. (2009). Reproductive decision-making in young women breast cancer survivors. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/10010

Chicago Manual of Style (16^th Edition):

Everson, Courtney Louise. “Reproductive decision-making in young women breast cancer survivors.” 2009. Masters Thesis, Oregon State University. Accessed April 11, 2021. http://hdl.handle.net/1957/10010.

MLA Handbook (7^th Edition):

Everson, Courtney Louise. “Reproductive decision-making in young women breast cancer survivors.” 2009. Web. 11 Apr 2021.

Vancouver:

Everson CL. Reproductive decision-making in young women breast cancer survivors. [Internet] [Masters thesis]. Oregon State University; 2009. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/1957/10010.

Council of Science Editors:

Everson CL. Reproductive decision-making in young women breast cancer survivors. [Masters Thesis]. Oregon State University; 2009. Available from: http://hdl.handle.net/1957/10010

University of Johannesburg

20. Minnaar, Carrie-Anne. The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment.

Degree: 2010, University of Johannesburg

URL: http://hdl.handle.net/10210/3161

►

M. Tech.

AIM: To determine the efficacy of Astragalus membranaceous tincture at maintaining the circulating white blood cell count (WBC) and absolute neutrophil count (ANC)… (more)

Subjects/Keywords: Breast cancer chemotherapy; Breast cancer treatment

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APA (6^th Edition):

Minnaar, C. (2010). The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/3161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Minnaar, Carrie-Anne. “The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment.” 2010. Thesis, University of Johannesburg. Accessed April 11, 2021. http://hdl.handle.net/10210/3161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Minnaar, Carrie-Anne. “The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment.” 2010. Web. 11 Apr 2021.

Vancouver:

Minnaar C. The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment. [Internet] [Thesis]. University of Johannesburg; 2010. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10210/3161.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Minnaar C. The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment. [Thesis]. University of Johannesburg; 2010. Available from: http://hdl.handle.net/10210/3161

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape

21. Janodien, Fatima. Proteome signature of breast cancer cells treated with fucoidan .

Degree: 2016, University of the Western Cape

URL: http://hdl.handle.net/11394/5315

► Breast cancer is responsible for a large portion of cancer-related deaths. Worldwide, incidence is increasing. Routinely-used treatments for breast cancer are invasive and are associated… (more)

Subjects/Keywords: Breast – Cancer – Treatment; Breast cancer; Fucoidan

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APA (6^th Edition):

Janodien, F. (2016). Proteome signature of breast cancer cells treated with fucoidan . (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/5315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Janodien, Fatima. “Proteome signature of breast cancer cells treated with fucoidan .” 2016. Thesis, University of the Western Cape. Accessed April 11, 2021. http://hdl.handle.net/11394/5315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Janodien, Fatima. “Proteome signature of breast cancer cells treated with fucoidan .” 2016. Web. 11 Apr 2021.

Vancouver:

Janodien F. Proteome signature of breast cancer cells treated with fucoidan . [Internet] [Thesis]. University of the Western Cape; 2016. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/11394/5315.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Janodien F. Proteome signature of breast cancer cells treated with fucoidan . [Thesis]. University of the Western Cape; 2016. Available from: http://hdl.handle.net/11394/5315

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Delaware

22. LoSavio, Stefanie T. Construct validity of fear of recurrence among breast cancer survivors.

Degree: PhD, University of Delaware, Department of Psychological and Brain Sciences, 2015, University of Delaware

URL: http://udspace.udel.edu/handle/19716/17447

► Advancements in cancer detection and treatment have improved the life expectancy of today's cancer patients. With patients living longer, many are now facing the challenges… (more)

Subjects/Keywords: Breast – Cancer – Patients.; Breast – Cancer – Relapse.; Fear.

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APA (6^th Edition):

LoSavio, S. T. (2015). Construct validity of fear of recurrence among breast cancer survivors. (Doctoral Dissertation). University of Delaware. Retrieved from http://udspace.udel.edu/handle/19716/17447

Chicago Manual of Style (16^th Edition):

LoSavio, Stefanie T. “Construct validity of fear of recurrence among breast cancer survivors.” 2015. Doctoral Dissertation, University of Delaware. Accessed April 11, 2021. http://udspace.udel.edu/handle/19716/17447.

MLA Handbook (7^th Edition):

LoSavio, Stefanie T. “Construct validity of fear of recurrence among breast cancer survivors.” 2015. Web. 11 Apr 2021.

Vancouver:

LoSavio ST. Construct validity of fear of recurrence among breast cancer survivors. [Internet] [Doctoral dissertation]. University of Delaware; 2015. [cited 2021 Apr 11]. Available from: http://udspace.udel.edu/handle/19716/17447.

Council of Science Editors:

LoSavio ST. Construct validity of fear of recurrence among breast cancer survivors. [Doctoral Dissertation]. University of Delaware; 2015. Available from: http://udspace.udel.edu/handle/19716/17447

Columbia University

23. Putcha, Preeti. HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers.

Degree: 2015, Columbia University

URL: https://doi.org/10.7916/D81835KX

► Inflammatory Breast Cancer (IBC) is a rare, lethal, and understudied form of breast cancer. Although affecting 1-2% of the population, the remission rate is half… (more)

Subjects/Keywords: Pathology; Cytology; Breast – Cancer; Breast – Cancer – Treatment

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APA (6^th Edition):

Putcha, P. (2015). HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D81835KX

Chicago Manual of Style (16^th Edition):

Putcha, Preeti. “HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers.” 2015. Doctoral Dissertation, Columbia University. Accessed April 11, 2021. https://doi.org/10.7916/D81835KX.

MLA Handbook (7^th Edition):

Putcha, Preeti. “HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers.” 2015. Web. 11 Apr 2021.

Vancouver:

Putcha P. HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers. [Internet] [Doctoral dissertation]. Columbia University; 2015. [cited 2021 Apr 11]. Available from: https://doi.org/10.7916/D81835KX.

Council of Science Editors:

Putcha P. HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers. [Doctoral Dissertation]. Columbia University; 2015. Available from: https://doi.org/10.7916/D81835KX

Boston University

24. Lee, Tian Yu. The role and function of SOX11 in DNA damage in triple-negative breast cancer.

Degree: MS, Medical Sciences, 2019, Boston University

URL: http://hdl.handle.net/2144/36570

► Breast cancer is a complex heterogenous disease that consists of several different subtypes displaying distinct behaviors and responses to different treatments. It is the second… (more)

Subjects/Keywords: Oncology; Breast cancer; Triple-negative breast cancer

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APA (6^th Edition):

Lee, T. Y. (2019). The role and function of SOX11 in DNA damage in triple-negative breast cancer. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/36570

Chicago Manual of Style (16^th Edition):

Lee, Tian Yu. “The role and function of SOX11 in DNA damage in triple-negative breast cancer.” 2019. Masters Thesis, Boston University. Accessed April 11, 2021. http://hdl.handle.net/2144/36570.

MLA Handbook (7^th Edition):

Lee, Tian Yu. “The role and function of SOX11 in DNA damage in triple-negative breast cancer.” 2019. Web. 11 Apr 2021.

Vancouver:

Lee TY. The role and function of SOX11 in DNA damage in triple-negative breast cancer. [Internet] [Masters thesis]. Boston University; 2019. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2144/36570.

Council of Science Editors:

Lee TY. The role and function of SOX11 in DNA damage in triple-negative breast cancer. [Masters Thesis]. Boston University; 2019. Available from: http://hdl.handle.net/2144/36570

University of Illinois – Chicago

25. Tossas-Milligan, Katherine Y. The Influence of Mammographic Density on Breast Cancer Risk.

Degree: 2018, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/22959

► High mammographic breast density (HBD) is a well-established risk factor for increased breast cancer (BC) incidence (1-4) and later stage of breast cancer diagnosis (5,… (more)

▼ High mammographic breast density (HBD) is a well-established risk factor for increased breast cancer (BC) incidence (1-4) and later stage of breast cancer diagnosis (5, 6). Mechanistically, HBD may mask BC at screening and result in interval BC being diagnosed at a later stage (5, 7-12). Biologically, HBD may be associated with increased cell proliferation and a general increase in mitogenic factors (13). However, the biological mechanisms through which HBD may operate to increase BC risk are not clearly defined, and its potential role in tumor progression and BC aggressiveness remains a debated issue. Given that most of the conclusions with regards to HBD and BC risk are based on primarily monoracial (non-Latina White women) studies, not much is known regarding if HBD affects women across various races and ethnicities differently. These racial/ethnic differences are particularly relevant within the context of existing racial/ethnic breast cancer mortality disparities in the United States where non-Latina Black (NLB) women, despite their lower BC incidence, are more likely to die from the disease compared to their non-Latina White (NLW) counterparts (14-17). While differential access to care, comorbidities, and BC aggressiveness are suggested in the literature as contributors to this difference (18-24), the potential impact of breast density on this disparity has not been explored. Understanding the effects of HBD on BC risk in a diverse cohort would add to the scarce literature regarding the effect of HBD across various race/ethnicities. In this dissertation, the researcher proposes to explore whether breast density differs across racial/ethnic groups and what factors may account for these differences. Additionally, the researcher proposes to explore the association between high breast density and breast cancer incidence, aggressiveness, and stage at diagnosis in a cohort of diverse women presenting for breast cancer screening at a large healthcare network in Metropolitan Chicago, with the following aims: Aim 1: To explore how breast density (BD) may differ by race/ethnicity and other individual level factors (BMI, age, hormonal) Aim 2: To explore if BD impacts breast cancer (BC) risk by subtype Aim 3: To explore potential mechanisms through which BD influences breast cancer stage at diagnosis Advisors/Committee Members: Rauscher, Garth H (advisor), Campbell, Richard (committee member), Seewaldt, Victoria (committee member), Friedewald, Sarah (committee member), Hoskins, Kent (committee member), Rauscher, Garth H (chair).

Subjects/Keywords: breast cancer risk; breast density; breast cancer disparities; breast density epidemiology

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APA (6^th Edition):

Tossas-Milligan, K. Y. (2018). The Influence of Mammographic Density on Breast Cancer Risk. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22959

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tossas-Milligan, Katherine Y. “The Influence of Mammographic Density on Breast Cancer Risk.” 2018. Thesis, University of Illinois – Chicago. Accessed April 11, 2021. http://hdl.handle.net/10027/22959.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tossas-Milligan, Katherine Y. “The Influence of Mammographic Density on Breast Cancer Risk.” 2018. Web. 11 Apr 2021.

Vancouver:

Tossas-Milligan KY. The Influence of Mammographic Density on Breast Cancer Risk. [Internet] [Thesis]. University of Illinois – Chicago; 2018. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10027/22959.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tossas-Milligan KY. The Influence of Mammographic Density on Breast Cancer Risk. [Thesis]. University of Illinois – Chicago; 2018. Available from: http://hdl.handle.net/10027/22959

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

26. Lopez Almeida, Leonor. Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells.

Degree: Docteur es, Pathologie humaine. Oncologie, 2017, Aix Marseille Université

URL: http://www.theses.fr/2017AIXM0653

►

Les chiffres mondiaux estiment l’incidence du cancer du sein, cancer féminin le plus fréquent, à 1.3 millions de cas par an, dont près d’un tiers… (more)

Subjects/Keywords: Cancer du sein; Breast cancer

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APA (6^th Edition):

Lopez Almeida, L. (2017). Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2017AIXM0653

Chicago Manual of Style (16^th Edition):

Lopez Almeida, Leonor. “Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells.” 2017. Doctoral Dissertation, Aix Marseille Université. Accessed April 11, 2021. http://www.theses.fr/2017AIXM0653.

MLA Handbook (7^th Edition):

Lopez Almeida, Leonor. “Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells.” 2017. Web. 11 Apr 2021.

Vancouver:

Lopez Almeida L. Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells. [Internet] [Doctoral dissertation]. Aix Marseille Université 2017. [cited 2021 Apr 11]. Available from: http://www.theses.fr/2017AIXM0653.

Council of Science Editors:

Lopez Almeida L. Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells. [Doctoral Dissertation]. Aix Marseille Université 2017. Available from: http://www.theses.fr/2017AIXM0653

University of Plymouth

27. Al-Thamiree, Safaa Salman Mezban. Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis.

Degree: PhD, 2019, University of Plymouth

URL: http://hdl.handle.net/10026.1/13585

► The effect of phytoestrogens on breast and prostate cancer cell lines - potential implications for bone preferential metastasis to bone Safaa Salman Mezban AL-Thamiree Abstract… (more)

▼ The effect of phytoestrogens on breast and prostate cancer cell lines - potential implications for bone preferential metastasis to bone Safaa Salman Mezban AL-Thamiree Abstract Many epidemiological studies indicate that diets rich in phytoestrogens (PE), especially soy and grain products, may be associated with a lower risk of some steroid hormone-dependent cancers such as breast and prostate. In particular PE have been shown to reduce the incidence of skeletal metastasis which have a high degree of morbidity and mortality. However, the most effective combinations of PEs and the mechanism through which they may reduce bone metastasis remain unclear. Therefore, this study aims to establish the most effective combinations of common dietary PE on breast and prostate cancer line proliferation, motility, and expression of genes implicated in disease progression and preferential metastasis to the skeleton. The potential modifying effect of cytokines that tumour cells are exposed to in the bone micro environment will also be studied including TGF-β, BMP7 and IL-33. Results showed that phytoestrogens genistein and daidzein significantly reduced prostate cancer cell viability (PC3 cells) with concentration 10-7 M (15 %, P = 0.01) and 10-6 M (11%, P = 0.04) for genistein and for daidzein the decrease in cell number was (18%, P value = 0.04) for 10-8 M and (22 %, P = 0.01) for 10-7 M. In breast cancer cell line (MCF7) genistein and coumestrol showed a significant decrease in cell number while daidzein did not. The decrease in (MCF7) cell number with genistein was (15 %, P = 0.04) and (25 %, P = 0.04) for 10-6 M and 10-5 M respectively, while in coumestrol concentrations 10-7 , 10-6 and 10-5 M showed the most significant decrease in cell number and were (29 %, P = 0.03), (34 %, P= 0.01) and (37%, value = 0.007) respectively. Motility results showed no significant reduction in the closure time of the scratch in both cell lines and there was an acceleration in the healing time of the scratch in both cell lines but was significant only in breast cell line (MCF7) with coumestrol after 6 ,12 and 24 hours at concentrations between (10-9 - 10-5 M). Non-selective oestrogen receptor modulator (ICI 182,780) abolishes the effect of genistein (10-7 and 10-6 M) and daidzein (10-8 and 10-7 M) reduction in cell viability and increased PC3 cell numbers significantly. In MCF7 cells, (ICI 182,780) also abolished the effect of coumestrol and genistein and increased the cell numbers but not to a significant levels. While genistein, daidzein and coumestrol reduced breast and prostate cell viability individually in an oestrogen receptor dependent manner and this beneficial effect is lost when the effective concentrations are combined. Although, transforming growth factor β (TGFβ), shows antagonist effect on phytoestrogens induced changes when combined with (daidzein and genistein) and blocks any effect of PEs and increase collagen type I gene expression. In MCF7 cells, the non-inhibitory effect of individual genistein on PTHrP is lost in the presence…

Subjects/Keywords: phytoestrogens; breast cancer; prostate cancer

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APA (6^th Edition):

Al-Thamiree, S. S. M. (2019). Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis. (Doctoral Dissertation). University of Plymouth. Retrieved from http://hdl.handle.net/10026.1/13585

Chicago Manual of Style (16^th Edition):

Al-Thamiree, Safaa Salman Mezban. “Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis.” 2019. Doctoral Dissertation, University of Plymouth. Accessed April 11, 2021. http://hdl.handle.net/10026.1/13585.

MLA Handbook (7^th Edition):

Al-Thamiree, Safaa Salman Mezban. “Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis.” 2019. Web. 11 Apr 2021.

Vancouver:

Al-Thamiree SSM. Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis. [Internet] [Doctoral dissertation]. University of Plymouth; 2019. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/10026.1/13585.

Council of Science Editors:

Al-Thamiree SSM. Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis. [Doctoral Dissertation]. University of Plymouth; 2019. Available from: http://hdl.handle.net/10026.1/13585

28. LOWRY, MICHELLE. Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles.

Degree: School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019, Trinity College Dublin

URL: http://hdl.handle.net/2262/86081

► Breast cancer is the most common female cancer diagnosed worldwide. In 2018 alone, there were over 2 million new breast cancer cases diagnosed. In Ireland,… (more)

Subjects/Keywords: Breast cancer; Cancer drug resistance

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APA (6^th Edition):

LOWRY, M. (2019). Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/86081

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

LOWRY, MICHELLE. “Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles.” 2019. Thesis, Trinity College Dublin. Accessed April 11, 2021. http://hdl.handle.net/2262/86081.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

LOWRY, MICHELLE. “Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles.” 2019. Web. 11 Apr 2021.

Vancouver:

LOWRY M. Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles. [Internet] [Thesis]. Trinity College Dublin; 2019. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/2262/86081.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

LOWRY M. Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles. [Thesis]. Trinity College Dublin; 2019. Available from: http://hdl.handle.net/2262/86081

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Namibia

29. Mowa, AK. An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek .

Degree: 2016, University of Namibia

URL: http://hdl.handle.net/11070/1853

► An alarming increase of breast cancer in Namibia started in 2005 with a record of 179 cases, and 1625 cases in 2006 respectively. To date,… (more)

▼ An alarming increase of breast cancer in Namibia started in 2005 with a record of 179 cases, and 1625 cases in 2006 respectively. To date, the cancer Association of Namibia (CAN) as a registry reported 3092 cancer incidences in 2012. The purpose of this study is to explore the Knowledge, Attitudes and Practices (KAP) and the correlation of the determinant factors on early detection of bread cancer among women in Windhoek. Methods used were the purposive sampling involving 236 women and simple random sampling for selecting six (6) health care facilities in Windhoek, Khomas region. The data collection was conducted over a period of three months, commencing in May 2015 and ended 31st July 2015. A structured questionnaire was used to interview 236 women. The questionnaire consisted of four sections such as Demography, Knowledge, Attitudes and Practice, cross tabulated with variables such as Age, Employment and Educational status. The data were analyzed by using the Statistical Package for Social Science (SPSS) software. The findings indicated that 78.8 % of women had knowledge on breast cancer and early detection, whereas 21.2% lacked the knowledge. The question about sources of information regarding breast cancer yielded the following, clinics recorded 34%, while Television (TV) and radio media with 32.7%. These sources were found to have played the biggest role in information sharing. Women with secondary education (64.5%) were more knowledgeable, followed by those with tertiary levels (29.5%). The age categories of 21-30 and 31- 40 indicated a sum of 46.8% to have knowledge on breast cancer. Attitudes among women on breast cancer practices, multiple responses were given. 92.5% responded that they would consult a Doctor, while 87.6% would be scared about the disease. Fewer responses came from women who wished to consult the traditional healers and prayer house (9.1% and 1.1%) respectively. About 90.5% of women happen to have medical insurance cover whereas 59.0% have no medical insurance cover. About 63% of women have practiced mammogram, while about 31% did not practice the mammogram screening. Employed women and student/ learners (83.3%), reported to be practicing mammogram, while 75.6% of the unemployed didn’t practice mammogram. Age categories of 21-30 and 41-49 recorded 72.1% and 66.7% respectively in practicing mammogram. The use of Clinical Breast Examination recorded a small fraction among respondents as only 27.5% visited the health facilities/ doctor for breast examination, while 72.5% were the women who did not seek any medical or visited the doctor for any clinical breast examination. In conclusion; even though the study findings revealed that the majority of women in Windhoek have a sound knowledge of breast cancer, there are still some negative attitudes towards the screenings and practices as stated in the problem statement that there is an alarming increase of breast cancer in Namibia, therefore the study recommends that, the Ministry of Health and Social Services in collaboration with the Cancer…

Subjects/Keywords: Breast cancer ; Breast, Cancer, Genetic aspects ; Breast, Cancer, Social aspects ; Breast, Cancer, Research

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mowa, A. (2016). An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek . (Thesis). University of Namibia. Retrieved from http://hdl.handle.net/11070/1853

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mowa, AK. “An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek .” 2016. Thesis, University of Namibia. Accessed April 11, 2021. http://hdl.handle.net/11070/1853.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mowa, AK. “An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek .” 2016. Web. 11 Apr 2021.

Vancouver:

Mowa A. An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek . [Internet] [Thesis]. University of Namibia; 2016. [cited 2021 Apr 11]. Available from: http://hdl.handle.net/11070/1853.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mowa A. An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek . [Thesis]. University of Namibia; 2016. Available from: http://hdl.handle.net/11070/1853

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

30. Wujcik, Debra M. Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program.

Degree: PhD, Nursing;, 2007, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2068/rec/916

► Breast cancer (BC) remains the most common cancer in women. Although screening mammography (SM) is an effective approach for early detection of BC, uninsured, underinsured,… (more)

▼ Breast cancer (BC) remains the most common cancer in women. Although screening mammography (SM) is an effective approach for early detection of BC, uninsured, underinsured, and minority women often do not have access to SM. The National Breast and Cervical Early Detection Program provide free access to SM. Of women who screen, 10-15% requires further testing, and half of those delay or do not return. Delay may contribute to later stage BC at diagnosis and increased rates of recurrence and death. This study was conducted to identify predictors of delay after an abnormal mammogram and predictors of rescreening behavior in women enrolled in the Tennessee Breast and Cervical Screening Program. Bivariate and multivariate logistic regression analyses were used to explore association between age, race, ethnicity, and marital status, BC history, and presence of breast symptoms and the outcomes of delay and rescreening behavior. Of 11,610 women, 37% required further testing. In a subset of women with time to completion > 1 day, 30% experienced delay > two months. Seventeen percent had another SM during the study period (2002-2006). The high percentage of women needing further testing is likely attributed to the program receiving referrals for diagnosis of symptomatic women as well as asymptomatic screening. Controlling for marital status, age, and BC history, there was more delay in test completion if the women African American versus Caucasian (OR 1.45, 95% CI 1.13, 1.85), Hispanic (OR .72, 95% CI 0.55, 0.93) and reported no breast symptoms (OR 1.50, 95% CI 1.27, 1.77). A delay in receipts of test results > 1 week contributed to the overall delay. Controlling for race and BC history, there was greater likelihood of rescreening if the women were married (OR 1.27, 95% CI 1.12, 1.43) and over 50 years of age (OR 1.92, 95% CI 1.67, 2.21) and less likelihood if the women were non-Hispanic (OR 0.71, 95% CI 0.60, 0.83) and had no breast symptoms (OR 0.85, 95% CI 0.76.,0.96). Findings can be used to identify women at risk for delay, assess understanding of the indication for further test, identify potential barriers to completion of testing or rescreening, and tailor interventions to overcome the barriers.

Subjects/Keywords: Breast Cancer; Health

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wujcik, D. M. (2007). Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2068/rec/916

Chicago Manual of Style (16^th Edition):

Wujcik, Debra M. “Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program.” 2007. Doctoral Dissertation, University of Utah. Accessed April 11, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2068/rec/916.

MLA Handbook (7^th Edition):

Wujcik, Debra M. “Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program.” 2007. Web. 11 Apr 2021.

Vancouver:

Wujcik DM. Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program. [Internet] [Doctoral dissertation]. University of Utah; 2007. [cited 2021 Apr 11]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2068/rec/916.

Council of Science Editors:

Wujcik DM. Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program. [Doctoral Dissertation]. University of Utah; 2007. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2068/rec/916

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