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Addis Ababa University
1.
FETENE, KASAHUN AMOGNE.
ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA
.
Degree: 2014, Addis Ababa University
URL: http://etd.aau.edu.et/dspace/handle/123456789/5662
► Background: Breast cancer is a disease of public health importance. It results in high morbidity and mortality in women worldwide. Breast examination as a screening…
(more)
▼ Background:
Breast cancer is a disease of public health importance. It results in high morbidity and mortality in women worldwide.
Breast examination as a screening tool for
breast cancer in developing countries is advocated in view of its cost-effectiveness.
Early detection of
breast cancer using
breast self-examination (BSE) plays an important role in decreasing its morbidity and mortality.
Objective: To assess
breast cancer awareness and practice of
breast self-examination among female students in Madawalabu University Bale, Ethiopia, 2014
Methods: Cross-sectional study design was employed from December –June, 2014 in Madawalabu University.
First the students were divided in to two practical strata, which are health science students and non-health science students. From each stratum, participants were selected by simple random sampling based on the proportion of the number of female students in each stratum that was 39 health science students and 383 non- health science students.
Self administered questionnaire was used to collect the data. Data were entered with Epi Info version 3.5.1 and analyzed using SPSS statistical package version 16.0. Bivariate and multivariate logistic regression analysis was performed.
Result: This study found that only [31.0%] of students had awareness about
breast cancer and [15.5%] practiced BSE. The three main reasons for not doing BSE were belief that there is no problem with their
breast [50.8%], not knowing the technique of BSE [40.0%], and Lack of privacy [15%].
Awareness about
breast cancer and got information about BSE by health professionals were found significantly associated with practice of BSE. Respondents in the health related disciplines were six times more likely to practice BSE than other respondents.
Conclusion: Awareness of
breast cancer and BSE practice was found low in this study. Having information on the importance of BSE was predictor of BSE practice.
Advisors/Committee Members: SR WORKINESH SINSHAW (BSc, RN, MSc) (advisor).
Subjects/Keywords: BREAST CANCER; BREAST
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
FETENE, K. A. (2014). ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA
. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5662
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
FETENE, KASAHUN AMOGNE. “ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA
.” 2014. Thesis, Addis Ababa University. Accessed April 11, 2021.
http://etd.aau.edu.et/dspace/handle/123456789/5662.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
FETENE, KASAHUN AMOGNE. “ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA
.” 2014. Web. 11 Apr 2021.
Vancouver:
FETENE KA. ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA
. [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Apr 11].
Available from: http://etd.aau.edu.et/dspace/handle/123456789/5662.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
FETENE KA. ASSESSMENT OF BREAST CANCER KNOWLEDGE AND PRACTICE OF BREAST SELF - EXAMINATION AMONG FEMALE STUDENTS IN MADAWALABU UNIVERSITY, BALE, ETHIOPIA
. [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5662
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New Mexico
2.
Smith, Randi L.
Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.
Degree: Biomedical Sciences Graduate Program, 2015, University of New Mexico
URL: https://digitalrepository.unm.edu/biom_etds/93
► Our recent studies have shown that Tumor Adjacent Histologically Normal (TAHN) breast tissue demonstrates many of the characteristics of breast tumors. For example, through immunohistochemical…
(more)
▼ Our recent studies have shown that Tumor Adjacent Histologically Normal (TAHN)
breast tissue demonstrates many of the characteristics of
breast tumors. For example, through immunohistochemical staining with markers such as alpha smooth muscle actin and TGF-β, we have shown the accumulation of myofibroblasts in TAHN tissues 1 cm from the tumor margin (TAHN-1). Additionally, TAHN-1 epithelia stain positive for epithelial to mesenchymal transition (EMT) associated proteins, such as transforming growth factor beta and alpha smooth muscle actin. The purpose of this study was to determine if TAHN-1 fibroblasts retained myofibroblast characteristics and if they could induce EMT in primary culture. We isolated primary cells from tissue specimens taken 1cm and 5cm from a
breast tumor (TAHN-1, TAHN-5). Primary fibroblasts were stained positive for myofibroblast markers, and contracted a collagen gel, demonstrating that these cells retain their myofibroblast characteristics. Primary fibroblast conditioned culture media was also able to induce EMT markers and migration normal epithelial
breast cells.
Advisors/Committee Members: Trujillo, Kristina, Garver, William Sherman, Hartley, Rebecca, Trujillo, Kristina.
Subjects/Keywords: Cancer; Breast Cancer
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Smith, R. L. (2015). Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. (Masters Thesis). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/biom_etds/93
Chicago Manual of Style (16th Edition):
Smith, Randi L. “Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.” 2015. Masters Thesis, University of New Mexico. Accessed April 11, 2021.
https://digitalrepository.unm.edu/biom_etds/93.
MLA Handbook (7th Edition):
Smith, Randi L. “Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture.” 2015. Web. 11 Apr 2021.
Vancouver:
Smith RL. Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. [Internet] [Masters thesis]. University of New Mexico; 2015. [cited 2021 Apr 11].
Available from: https://digitalrepository.unm.edu/biom_etds/93.
Council of Science Editors:
Smith RL. Tumor Promoting Properties of Field Cancerized Fibroblasts in Cell Culture. [Masters Thesis]. University of New Mexico; 2015. Available from: https://digitalrepository.unm.edu/biom_etds/93

University of Alberta
3.
Bernier, Ashlyn.
Mechanisms of MUC1/ICAM-1 signalling in breast cancer
metastasis.
Degree: PhD, Medical Sciences - Laboratory Medicine and
Pathology, 2011, University of Alberta
URL: https://era.library.ualberta.ca/files/db78td08r
► Breast cancer is the second leading cause of cancer death in Canadian women. In these patients, mortality is due to metastasis of cancer cells from…
(more)
▼ Breast cancer is the second leading cause of cancer
death in Canadian women. In these patients, mortality is due to
metastasis of cancer cells from the breast to distant organs,
resulting in impairment of function. To metastasize, cells must
move through the stroma of the breast, enter the circulation,
survive transit, exit the circulation, and form a secondary tumor.
A critical component of this metastatic cascade is cancer cell
motility. It is not fully understood how breast cancer cells gain
the ability to move or what signaling pathways mediate these
events, and identification of critical components of these pathways
would represent potential targets for anti-metastatic therapies.
The MUC1 glycoprotein is expressed on the apical membrane of normal
breast epithelia. In many human breast carcinomas, MUC1 is
overexpressed and loses apical polarization, events that correlate
with increased metastasis. The contribution of MUC1 overexpression
to increased metastasis is not completely understood, with the
majority of studies attributing an anti-adhesive role to MUC1.
Several critical steps of the metastatic cascade require cell
adhesion, and it has been reported that MUC1 is a ligand for
ICAM-1, which is expressed throughout the migratory tract of a
metastasizing breast cancer cell. It was subsequently reported that
MUC1/ICAM-1 binding initiates calcium oscillations, cytoskeletal
reorganization, and cell migration, suggesting that binding could
be important in metastasis. Here, we investigate the mechanism of
MUC1/ICAM-1 binding induced signaling. We show that Src kinase is a
critical component of the MUC1/ICAM-1 signalling axis, and that
MUC1 forms constitutive dimers which are required for Src
recruitment and ICAM-1 binding induced signaling. We show that MUC1
dimers are not covalently linked and do not require cytoplasmic
domain cysteine residues, contrary to other reports. We show that
MUC1 extracellular domain shedding is not required for
dimerization, Src recruitment, or ICAM-1 binding induced calcium
oscillations, although it is required for migration. Lastly, we
show that autoproteolytic cleavage of MUC1 is not required for
normal function. These results reveal information on the mechanism
of MUC1/ICAM-1 signalling, which can be used to identify novel
targets and combinational strategies for anti-metastatic therapy in
breast cancer.
Subjects/Keywords: Breast Cancer
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Bernier, A. (2011). Mechanisms of MUC1/ICAM-1 signalling in breast cancer
metastasis. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/db78td08r
Chicago Manual of Style (16th Edition):
Bernier, Ashlyn. “Mechanisms of MUC1/ICAM-1 signalling in breast cancer
metastasis.” 2011. Doctoral Dissertation, University of Alberta. Accessed April 11, 2021.
https://era.library.ualberta.ca/files/db78td08r.
MLA Handbook (7th Edition):
Bernier, Ashlyn. “Mechanisms of MUC1/ICAM-1 signalling in breast cancer
metastasis.” 2011. Web. 11 Apr 2021.
Vancouver:
Bernier A. Mechanisms of MUC1/ICAM-1 signalling in breast cancer
metastasis. [Internet] [Doctoral dissertation]. University of Alberta; 2011. [cited 2021 Apr 11].
Available from: https://era.library.ualberta.ca/files/db78td08r.
Council of Science Editors:
Bernier A. Mechanisms of MUC1/ICAM-1 signalling in breast cancer
metastasis. [Doctoral Dissertation]. University of Alberta; 2011. Available from: https://era.library.ualberta.ca/files/db78td08r
4.
Liu, Tianli.
Long Term Health Outcomes of Prenatal Exposure to Cigarette
Smoking.
Degree: PhD, Division of Biology and Medicine.
Epidemiology, 2009, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:198/
► This dissertation focuses on the long term health outcomes of prenatal exposure to cigarette smoke. We hypothesize that exposure to toxins through maternal smoking could…
(more)
▼ This dissertation focuses on the long term health
outcomes of prenatal exposure to cigarette smoke. We hypothesize
that exposure to toxins through maternal smoking could affect the
hypothalamus of the fetal brain, subsequently leading to a long
term impact on physical and mental health. Three epidemiologic
studies were conducted to test this hypothesis. Study one is a
prospective cohort study examining whether maternal smoking during
pregnancy increased the risk of benign
breast disease (BBD) among
adult female offspring. The study results suggested that women
whose mothers smoked during pregnancy were more than two times more
likely to develop BBD in their adulthood than women whose mothers
never smoked during pregnancy. We consider that the findings were
consistent with our hypothesis. The hypothalamus is the control
center of the brain for sex hormone release. A toxic influence on
the hypothalamus might induce a sex hormone imbalance which
subsequently leads to BBD. Study two further examined the
relationship between postnatal smoking exposures and risk of BBD.
None of these postnatal smoking exposures were found to be
independently associated with the risk of BBD. These findings
confirmed our hypothesis that exposure to cigarette smoking during
the prenatal period, instead of the postnatal period, predicted an
increased risk of BBD. The programming of the hypothalamus is
taking place during the prenatal period, when the blood-brain
barrier, which prevents the passage of many toxic agents into the
brain, is not fully developed. We conclude that the prenatal period
is a unique time during which toxic agents can impact the fetal
brain. As the hypothalamus not only controls sex hormone balance,
but also anger and rage, in study three, we examined the
relationship between maternal smoking during pregnancy and anger
temperament of the offspring using several sets of analyses. The
results consistently showed that maternal smoking during pregnancy
was associated with an increased level of anger temperament among
adult offspring. We consider the results support our hypothesis.
Prenatal exposure to cigarette smoking might have disturbed the
normal development and organization of the hypothalamus, and in
doing so, would have an impact on anger temperament.
Advisors/Committee Members: Buka, Stephen (director), Gatsonis, Constantine (reader), Baylin, Ana (reader).
Subjects/Keywords: breast cancer
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Liu, T. (2009). Long Term Health Outcomes of Prenatal Exposure to Cigarette
Smoking. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:198/
Chicago Manual of Style (16th Edition):
Liu, Tianli. “Long Term Health Outcomes of Prenatal Exposure to Cigarette
Smoking.” 2009. Doctoral Dissertation, Brown University. Accessed April 11, 2021.
https://repository.library.brown.edu/studio/item/bdr:198/.
MLA Handbook (7th Edition):
Liu, Tianli. “Long Term Health Outcomes of Prenatal Exposure to Cigarette
Smoking.” 2009. Web. 11 Apr 2021.
Vancouver:
Liu T. Long Term Health Outcomes of Prenatal Exposure to Cigarette
Smoking. [Internet] [Doctoral dissertation]. Brown University; 2009. [cited 2021 Apr 11].
Available from: https://repository.library.brown.edu/studio/item/bdr:198/.
Council of Science Editors:
Liu T. Long Term Health Outcomes of Prenatal Exposure to Cigarette
Smoking. [Doctoral Dissertation]. Brown University; 2009. Available from: https://repository.library.brown.edu/studio/item/bdr:198/

Addis Ababa University
5.
DURETI, GENA.
KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS
.
Degree: 2013, Addis Ababa University
URL: http://etd.aau.edu.et/dspace/handle/123456789/7004
► Breast cancer is one of the most common cancers and a major cause of death among women worldwide. Each year, breast cancer is newly diagnosed…
(more)
▼ Breast cancer is one of the most common cancers and a major cause of death among
women worldwide. Each year,
breast cancer is newly diagnosed in more than one
million women worldwide. This study was a cross sectional survey in which a
questionnaire was presented for186 female student in Hawasa and Meda Welabu
University in order to assess their level of knowledge, relation of perceived
susceptibility, perceived severity with preventive behaviour to
breast cancer and
major perceived barriers to different screening methods. Each question in the
questionnaire was scored using a 5-point likert scale ranged from strongly agree (5)
to strongly disagree (1). Negatively worded questions had their scales reversed.
Correlation analysis was used to test for association of perceived susceptibility,
perceived severity, with preventive behavior and frequency and percentage analysis
was used to identify major barriers to different screening methods. All analyses were
conducted using SPSS version 17. The result of the study showed only 3.8 % of the
participants was knowledgeable about the risk factors, symptoms and signs of
breast
cancer.For the overall preventive behaviours of the respondents, and the percentage
of the good practices was (12.9%) however (87.1%) need improvement. In addition
participants reported relatively few perceived barriers to different screening methods
performance (89.3%). As a conclusion the present study showed that participants had
a low level of knowledge and revealed a strong association between perceived
susceptibility and preventive behaviour of
breast cancer(r=0.64), as well as moderate
correlation between perceived severity and preventive behaviour of
breast
cancer(r=0.43) . Major perceived barriers found were perceived screening methods
as painful, embarrassment, and feel fearful that they would not be able to do properly.
Advisors/Committee Members: Eng. Mohammed Sama (advisor).
Subjects/Keywords: Breast cancer
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
DURETI, G. (2013). KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS
. (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/7004
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
DURETI, GENA. “KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS
.” 2013. Thesis, Addis Ababa University. Accessed April 11, 2021.
http://etd.aau.edu.et/dspace/handle/123456789/7004.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
DURETI, GENA. “KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS
.” 2013. Web. 11 Apr 2021.
Vancouver:
DURETI G. KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS
. [Internet] [Thesis]. Addis Ababa University; 2013. [cited 2021 Apr 11].
Available from: http://etd.aau.edu.et/dspace/handle/123456789/7004.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
DURETI G. KNOWLEDGE AND PERCEPTION REGARDING BREAST CANCER PREVENTION AMONG UNIVERSITY STUDENTS
. [Thesis]. Addis Ababa University; 2013. Available from: http://etd.aau.edu.et/dspace/handle/123456789/7004
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University
6.
Dewi, Fitriya Nur Annisa.
THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES.
Degree: 2013, Wake Forest University
URL: http://hdl.handle.net/10339/39018
► Diet has been thought to modify developmental regulation and subsequently influence later-life susceptibility to various diseases including cancer. Meta-analyses showed that the intake of soy,…
(more)
▼ Diet has been thought to modify developmental regulation and subsequently influence later-life susceptibility to various diseases including cancer. Meta-analyses showed that the intake of soy, which contains the phytoestrogenic compounds isoflavones (IFs), is associated with reduced breast cancer risk. A similar relationship has been reported for soy and endometrial cancer, although the evidence is more limited. Interestingly, the inverse association between soy and breast cancer is more consistent when soy exposure occurs preceding puberty. Our primary aim was to investigate the effect of soy consumption beginning pre-adulthood on the breast and uterine tissues in relation to estrogen action. We utilized two animal models: cynomolgus macaques and apolipoprotein E-null mice. The macaque study longitudinally assessed tissue changes across pubertal development to model young girls consuming a North American diet with/without soy IF exposure. We found that soy intake did not alter pubertal growth, menarche, or uterine development. Soy exposure initiated at puberty promoted mammary gland differentiation which resulted in a breast composed of abundant mature lobular structures in adulthood, a phenotype consistent with low cancer risk. We observed a modestly lower expression of ERs and ER activity markers, suggesting that early soy exposure could potentially result in lower estrogen-responsiveness in the adult breast. These changes were not associated with differential circulating estradiol and progesterone, CpG methylation within the specific promoter regions examined, or expression of intramammary estrogen-metabolizing enzymes. To explain whether the soy effect is dependent on the primary IF metabolite equol, we conducted a study whereby mice were modified to have equol-producing vs. non-equol-producing capability to model the low frequency of equol production observed in human populations. Mice were fed dietary soy with/without exogenous equol starting at peripubertal age. Equol, but not a soy diet per se, modulated estrogen-dependent uterine responses; the effect was less clear in the breast. Female equol producers had lower estrogenic reproductive tissue phenotypes compared to nonproducers, regardless of IF dose. Collectively, our findings indicate that pubertal exposure to soy may have a subtle effect in promoting breast differentiation and downregulating estrogen-responsiveness. Equol and/or equol-producing microbiota may influence estrogen-associated tissue phenotype and response to soy diet.
Subjects/Keywords: Breast cancer
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Dewi, F. N. A. (2013). THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/39018
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Dewi, Fitriya Nur Annisa. “THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES.” 2013. Thesis, Wake Forest University. Accessed April 11, 2021.
http://hdl.handle.net/10339/39018.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Dewi, Fitriya Nur Annisa. “THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES.” 2013. Web. 11 Apr 2021.
Vancouver:
Dewi FNA. THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES. [Internet] [Thesis]. Wake Forest University; 2013. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10339/39018.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Dewi FNA. THE EFFECTS OF PUBERTAL EXPOSURE TO DIETARY SOY ISOFLAVONES ON THE BREAST AND REPRODUCTIVE TISSUES. [Thesis]. Wake Forest University; 2013. Available from: http://hdl.handle.net/10339/39018
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wake Forest University
7.
Liu, Yin.
BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY.
Degree: 2018, Wake Forest University
URL: http://hdl.handle.net/10339/90710
► Breast cancer is one of major public health problem worldwide. However, the underlying molecular mechanism of breast cancer progression and metastasis is not well understood.…
(more)
▼ Breast cancer is one of major public health problem worldwide. However, the underlying molecular mechanism of breast cancer progression and metastasis is not well understood. Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer which could progress to or recur as invasive breast cancer. To identify the novel regulators of DCIS progression, we performed gene expression analysis of syngeneic cell lines MCF10A, DCIS.com and MCF10CA and cross-referenced the targets using patient cohorts. By comparing gene expression between MCF10A and DCIS.com cell line, we identified ID2 as a regulator of DCIS initiation. ID2 promoted DCIS formation by enhancing cancer stemness of premalignant cells. On the other hand, we compared the DCIS.com and invasive breast cancer cell line, MCF10CA, and identified INHBA and GJB2 as novel regulators of aggressive phenotype. These 2 genes regulated migration, colonization and stemness of invasive cancer cells. Finally, we identified an ID2 inhibitor, natural compound Helichrysetin.
Subjects/Keywords: Breast cancer
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Liu, Y. (2018). BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/90710
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Liu, Yin. “BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY.” 2018. Thesis, Wake Forest University. Accessed April 11, 2021.
http://hdl.handle.net/10339/90710.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Liu, Yin. “BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY.” 2018. Web. 11 Apr 2021.
Vancouver:
Liu Y. BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY. [Internet] [Thesis]. Wake Forest University; 2018. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10339/90710.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Liu Y. BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY. [Thesis]. Wake Forest University; 2018. Available from: http://hdl.handle.net/10339/90710
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

California State Polytechnic University – Pomona
8.
Lolarga, Jade.
A Study of the Regulation of Breast Cancer Cell Invasion.
Degree: MS, Department of Biological Sciences, 2020, California State Polytechnic University – Pomona
URL: http://hdl.handle.net/10211.3/216845
► Metastasis occurs when cancer cells spread from their primary site to other tissues in the body, which is the main cause of death in most…
(more)
▼ Metastasis occurs when
cancer cells spread from their primary site to other tissues in the body, which is the main cause of death in most
cancer patients. Metastasis is a multistep process and the initial step is the invasion of
cancer cells to neighboring tissues. It is therefore important to understand the molecular mechanism underlying the regulation of cell invasion. TWIST1 is a transcription factor that has been previously identified as a key regulator of metastasis. BMI1 is a transcription target of TWIST1 and a subunit of Polycomb Repressive Complex 1 (PRC1) that possesses E3 ubiquitinating ligase activity. By mono-ubiquitinating histone H2A at Lysine 119 (K119), PRC1 can cause gene silencing. Our preliminary data showed that BMI1 works downstream of TWIST1 in promoting
breast cancer cell invasion.
On the other hand, USP16 is a deubiquitinase and is able to remove the ubiquitin from K119 of histone H2A. Our previous data has shown that Polo-like kinase 1 (PLK1) phosphorylates and activates USP16. We hypothesized that the PLK1-USP16 -mediated deubiquitination of histone H2A could inhibit the invasion of
breast cancer cells by antagonizing TWIST1-BMI1-mediated ubiquitination at the same residue (K119) of histone H2A. To study
cancer cell invasion regulated by these two molecular pathways, we adopted and optimized a three-dimensional (3D) cell culture system to analyze the invasiveness of
cancer cells. This newly developed 3D tumor spheroid invasion assay provides data that more closely represents the in vivo behavior of
cancer cells and is therefore rapidly gaining popularity among
cancer researchers. In this study, we investigated the invasion of
breast cancer cells regulated by TWIST1-BMI1 and PLK1- USP16 pathways in the 3D setting. The results supported our hypothesis that TWIST1-BMI1 pathway promotes
cancer cell invasion, whereas PLK1-USP16 pathway inhibits the invasion. Furthermore, we showed that a harmala alkaloid called harmine could induce the degradation of TWIST1 and therefore inhibit
breast cancer cell invasion in a dose-dependent manner. These results help us to better understand the regulation of metastasis and may contribute to the development of novel approaches for the treatment of metastatic
breast cancer.
Advisors/Committee Members: Liu, Junjun (advisor), Adler-Moore, Jill (committee member).
Subjects/Keywords: breast cancer
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APA (6th Edition):
Lolarga, J. (2020). A Study of the Regulation of Breast Cancer Cell Invasion. (Masters Thesis). California State Polytechnic University – Pomona. Retrieved from http://hdl.handle.net/10211.3/216845
Chicago Manual of Style (16th Edition):
Lolarga, Jade. “A Study of the Regulation of Breast Cancer Cell Invasion.” 2020. Masters Thesis, California State Polytechnic University – Pomona. Accessed April 11, 2021.
http://hdl.handle.net/10211.3/216845.
MLA Handbook (7th Edition):
Lolarga, Jade. “A Study of the Regulation of Breast Cancer Cell Invasion.” 2020. Web. 11 Apr 2021.
Vancouver:
Lolarga J. A Study of the Regulation of Breast Cancer Cell Invasion. [Internet] [Masters thesis]. California State Polytechnic University – Pomona; 2020. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10211.3/216845.
Council of Science Editors:
Lolarga J. A Study of the Regulation of Breast Cancer Cell Invasion. [Masters Thesis]. California State Polytechnic University – Pomona; 2020. Available from: http://hdl.handle.net/10211.3/216845

Harvard University
9.
Natsuhara, Kelsey H.
Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria.
Degree: Doctor of Medicine, 2018, Harvard University
URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973486
► Purpose: For clinically appropriate early-stage breast cancer patients, reflex criteria for Oncotype DX ordering (“the intervention”) was implemented at our comprehensive cancer center, which reduced…
(more)
▼ Purpose: For clinically appropriate early-stage breast cancer patients, reflex criteria for Oncotype DX ordering (“the intervention”) was implemented at our comprehensive cancer center, which reduced time-to-adjuvant chemotherapy initiation. Our objective was to evaluate Oncotype DX ordering practices and chemotherapy use pre- and post-intervention.
Methods: We examined medical records for 498 patients who had definitive breast cancer surgery at our center. The post-intervention cohort consisted of 232 consecutive patients who had Oncotype DX testing after reflex criteria implementation and were compared to a retrospective cohort of 266 patients, including those who did and did not have Oncotype DX ordered before reflex criteria implementation. Factors associated with Oncotype DX ordering pre- and post- intervention were examined. We used multivariate logistic regression to evaluate factors associated with chemotherapy receipt among patients with Oncotype DX testing.
Results: The distribution of Oncotype DX scores, the proportion of those having Oncotype DX testing (28.9% vs. 34.1%) and those receiving chemotherapy (14.3% vs 19.4%) did not significantly change between pre- and post-intervention. Age <65 years, stage II, grade II, 1-3+ nodes, and tumor size >2cm were associated with higher odds of Oncotype DX testing. Among patients having Oncotype DX testing, node status and Oncotype DX scores were significantly associated with chemotherapy receipt.
Conclusion: Our criteria for reflex Oncotype DX ordering appropriately targeted patients for whom Oncotype DX would typically be ordered by providers. No significant change in the rate of Oncotype DX ordering or chemotherapy use was observed after reflex testing implementation.
Scholarly Project
Subjects/Keywords: breast cancer
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APA (6th Edition):
Natsuhara, K. H. (2018). Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973486
Chicago Manual of Style (16th Edition):
Natsuhara, Kelsey H. “Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria.” 2018. Doctoral Dissertation, Harvard University. Accessed April 11, 2021.
http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973486.
MLA Handbook (7th Edition):
Natsuhara, Kelsey H. “Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria.” 2018. Web. 11 Apr 2021.
Vancouver:
Natsuhara KH. Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria. [Internet] [Doctoral dissertation]. Harvard University; 2018. [cited 2021 Apr 11].
Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973486.
Council of Science Editors:
Natsuhara KH. Impact of Genomic Assay Testing and Clinical Factors on Chemotherapy Use After Implementation of Standardized Testing Criteria. [Doctoral Dissertation]. Harvard University; 2018. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:41973486

California State Polytechnic University – Pomona
10.
Lam, Brandon.
Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion.
Degree: MS, Department of Biological Sciences, 2020, California State Polytechnic University – Pomona
URL: http://hdl.handle.net/10211.3/214977
► Breast cancer is the most common non-skin cancer among American women. Comparing with early stage breast cancer, Stage IV or metastatic breast cancer has much…
(more)
▼ Breast cancer is the most common non-skin
cancer among American women. Comparing with early stage
breast cancer, Stage IV or metastatic
breast cancer has much lower 5 year survival rate (22%) and is a major threat to women???s health. The metastatic process originates at the primary tumor and causes secondary tumors at distant places, which can eventually lead to death. In
breast cancer, the transition from an in situ tumor to a metastatic one occurs with a process called Epithelial-Mesenchymal Transition (EMT). EMT hallmarks of carcinoma cells include self-renewal, cell proliferation, increased cell invasion, and resistance to chemotherapeutics. One of the key proteins regulating this process is the transcription factor Twist1. Elevated expression of Twist1 has been found in highly invasive head-and-neck, lung, colorectal, and
breast cancers, and likewise indicates poor prognosis for patients. Bmi1 is a downstream transcription target of Twist1. It interacts with Ring 1b to form part of an ubiquitinating complex called PRC1, which is responsible for chromatin remodeling and epigenetically regulating cell proliferation, self-renewal and ???stem-like??? properties. However, the processes regulating Bmi1 and Ring1b interaction and thus PRC1 activity are not well understood.
In our previous studies, we have found that Twist1-Bmi1 pathway promotes
breast cancer cell invasion. Recently, it was reported that a novel drug harmine could inhibit Twist1 and reduce the invasiveness of lung
cancer cells. This leads us to hypothesize that harmine could also inhibit
breast cancer cell invasion by targeting Twist1 in a dose dependent manner. Our results have confirmed this hypothesis. Furthermore, we have shown that the inhibition on
breast cancer cell invasion is achieved by inducing proteasome-mediated Twist1 degradation. Meanwhile, we show that Bmi1 phosphorylation is cell cycle regulated. In M phase, Bmi1 is hyperphosphorylated, which is likely to disrupt its interaction with Ring1b leading to inactivation of PRC1; whereas in interphase, the hypophosphorylation of Bmi1 promotes Bmi1-Ring1b interaction and therefore the activation of PRC1, which ultimately leads to
cancer cell invasion. Future work includes the identification of upstream kinase that phosphorylates Bmi1, and verification of harmine-induced inhibition on
cancer cell invasion in vivo. In conclusion, targeting Twist1 and its downstream proteins such as Bmi1 could provide novel approaches for the treatment of metastatic
breast cancer.
Advisors/Committee Members: Liu, Junjun (advisor), Lin, Wei-Jen (committee member).
Subjects/Keywords: breast cancer
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lam, B. (2020). Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion. (Masters Thesis). California State Polytechnic University – Pomona. Retrieved from http://hdl.handle.net/10211.3/214977
Chicago Manual of Style (16th Edition):
Lam, Brandon. “Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion.” 2020. Masters Thesis, California State Polytechnic University – Pomona. Accessed April 11, 2021.
http://hdl.handle.net/10211.3/214977.
MLA Handbook (7th Edition):
Lam, Brandon. “Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion.” 2020. Web. 11 Apr 2021.
Vancouver:
Lam B. Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion. [Internet] [Masters thesis]. California State Polytechnic University – Pomona; 2020. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10211.3/214977.
Council of Science Editors:
Lam B. Targeting Twist1 and its downstream protein Bmi1 to inhibit breast cancer cell invasion. [Masters Thesis]. California State Polytechnic University – Pomona; 2020. Available from: http://hdl.handle.net/10211.3/214977

University of Melbourne
11.
Sawyer, Sarah Dilys.
A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families.
Degree: 2014, University of Melbourne
URL: http://hdl.handle.net/11343/55238
► Breast cancer remains a significant health issue with the highest incidence and the second highest cause of cancer-related mortality amongst women worldwide. A family history…
(more)
▼ Breast cancer remains a significant health issue with the highest incidence and the second highest cause of cancer-related mortality amongst women worldwide. A family history is an important risk factor, with women found to be twice as likely to develop the disease if they have one first-degree relative affected with breast cancer. It is the role of familial cancer clinics (FCCs) and genetic testing services to identify ‘high-risk’ individuals and offer genetic testing to eligible individuals looking for mutations within high-penetrance genes, such as BRCA1 and BRCA2. For mutation carriers, cancer risk assessment and management is based on a well-established foundation of evidence. However, up to 80% of individuals have no identifiable BRCA mutation, resulting in risk assessment and management advice that is based only on family history and is no longer personalised but instead directed by summary data from epidemiological studies of the general population.
Researchers have continued the search for the other genetic causes of the heritable fraction of breast cancer through large, collaborative genome-wide association studies (GWAS). To date, these studies have identified over 70 common variants associated with breast cancer risk. Individually, the associations for these variants are too weak to be useful (relative risk <1.5), however, when the risks for these variants are combined multiplicatively (termed polygenic risk) the risk becomes more appreciable. It is estimated that up to 28% of familial breast cancer risk can be explained by common variants. Despite this, genetic testing for common genomic variants has yet to be implemented into routine clinical practice.
This study explores the clinical significance and implications of common genomic variants to the assessment and risk management of high-risk breast and ovarian cancer families, to generate the data required to facilitate the translation of common variant genetic testing into clinical practice.
To conduct this research, the study utilised the Victorian Familial Breast and Ovarian Cancer Cohort (VFBOCC) which consists of individuals (female index cases) who have been assessed as high-risk for breast and/or ovarian cancer based on their personal and family history of cancer. In Chapter 3, the development of a database that systematically incorporated and allowed for the well-defined characterisation of the VFBOCC is discussed. This database framework facilitated a detailed analysis of the cohort; it identified that females in this cohort have an average breast cancer age of onset of 44.9 years, which is much lower than the average age of onset observed in the general population, and that only 22% of the VFBOCC had a BRCA1 or BRCA2 mutation identified by diagnostic genetic testing. The establishment of this database enabled the VFBOCC data to be utilised in common genomic variant research as part of this thesis as well as within several collaborations which are also investigating the potential role of recently discovered rare genetic variations to…
Subjects/Keywords: breast cancer
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Sawyer, S. D. (2014). A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/55238
Chicago Manual of Style (16th Edition):
Sawyer, Sarah Dilys. “A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families.” 2014. Doctoral Dissertation, University of Melbourne. Accessed April 11, 2021.
http://hdl.handle.net/11343/55238.
MLA Handbook (7th Edition):
Sawyer, Sarah Dilys. “A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families.” 2014. Web. 11 Apr 2021.
Vancouver:
Sawyer SD. A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families. [Internet] [Doctoral dissertation]. University of Melbourne; 2014. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/11343/55238.
Council of Science Editors:
Sawyer SD. A translational analysis of the genomic variation associated with breast cancer in hereditary breast and ovarian cancer families. [Doctoral Dissertation]. University of Melbourne; 2014. Available from: http://hdl.handle.net/11343/55238

University of Hawaii – Manoa
12.
Higa, Jason Kenji.
Inflammation and breast cancer prevention by phyllostachys edulis extract.
Degree: 2016, University of Hawaii – Manoa
URL: http://hdl.handle.net/10125/102030
► Ph.D. University of Hawaii at Manoa 2013.
Obesity affects roughly one-third of American adults, in which chronic inflammation and lipotoxicity are disorders that are frequently…
(more)
▼ Ph.D. University of Hawaii at Manoa 2013.
Obesity affects roughly one-third of American adults, in which chronic inflammation and lipotoxicity are disorders that are frequently found in conjunction. An estimated 232,340 American women are predicted to be diagnosed with breast cancer (BrCa) in 2013, and 39,620 are expected to die from it. Obesity does not guarantee that a woman will develop BrCa, but it increases her risk of developing it.
This dissertation focuses on the potential therapeutic effects of an extract from the bamboo Phyllostachys edulis as related to lipotoxicity-induced inflammation and breast cancer. Bamboo extract (BEX) has previously demonstrated anti-lipotoxic effects.
In the present study, which used in vitro cell culture models mimicking lipotoxic conditions, BEX was found to decrease production of the inflammatory cytokines IL-6 and MCP-1, inhibit nuclear translocation of the proinflammatory transcription factors NF-κB and AP-1, and increase activity of the antiinflammatory transcription factors Nrf2 and PPARγ. An in vivo study showed that BEX could also inhibit MCP-1 production in mice when supplemented into a high fat diet. Tricin and 7-O-methyl tricin (7MT) were isolated from BEX, and both compounds had inhibitory effects on lipotoxicity-induced MCP-1 production. On the topic of breast cancer, BEX showed inhibitory effects on multiple BrCa cell lines while showing minimal toxicity to MCF-10A, a non-carcinoma mammary cell line. BEX appeared to induce protective effects in MCF-10A cells by increasing expression of genes involved with DNA damage and repair and inducing antioxidant signaling and activity. BrCa cell lines showed varied responses to inhibition by tricin, 7MT, and other compounds reportedly isolated from P. edulis. BEX did not bind to or activate estrogen receptor alpha at physiological levels. A proteomics study carried out on MCF7 cells treated with BEX, tricin, and 7MT suggested that BEX and its compounds may alter cytoskeletal structures, and inhibit mTOR and IGF-1R signaling.
Subjects/Keywords: breast cancer
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Higa, J. K. (2016). Inflammation and breast cancer prevention by phyllostachys edulis extract. (Thesis). University of Hawaii – Manoa. Retrieved from http://hdl.handle.net/10125/102030
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Higa, Jason Kenji. “Inflammation and breast cancer prevention by phyllostachys edulis extract.” 2016. Thesis, University of Hawaii – Manoa. Accessed April 11, 2021.
http://hdl.handle.net/10125/102030.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Higa, Jason Kenji. “Inflammation and breast cancer prevention by phyllostachys edulis extract.” 2016. Web. 11 Apr 2021.
Vancouver:
Higa JK. Inflammation and breast cancer prevention by phyllostachys edulis extract. [Internet] [Thesis]. University of Hawaii – Manoa; 2016. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10125/102030.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Higa JK. Inflammation and breast cancer prevention by phyllostachys edulis extract. [Thesis]. University of Hawaii – Manoa; 2016. Available from: http://hdl.handle.net/10125/102030
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University
13.
Estrella, Brian, 1989-.
Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene.
Degree: PhD, Toxicology, 2018, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/57543/
► Fry is an evolutionarily-conserved gene involved in cellular differentiation, division, morphology, polarity, and adhesion. Decreased expression of the FRY protein in breast cancer cell lines…
(more)
▼ Fry is an evolutionarily-conserved gene involved in cellular differentiation, division, morphology, polarity, and adhesion. Decreased expression of the FRY protein in
breast cancer cell lines reduced the expression of gene networks associated with epithelial differentiation, morphology, polarity and adhesion. Ectopic expression of the wild-type rat Fry gene in human
breast cancer cells restored a gene expression profile associated with differentiation, suppression of epithelial-mesenchymal transition.
Breast cancer cells expressing wild-type Fry at physiological levels reacquired a non-transformed morphology in vitro and a non-tumorigenic in vivo phenotype in the nude mouse xenograft model. We further determined that expression of FRY mRNA and protein correlated with
breast cancer phenotypes such as Elston tumor grade, estrogen receptor, progesterone receptor, and Her2 receptor status. Despite these finding, significant gaps in knowledge remain in our understanding of how FRY expression is decreased during tumor progression. Based on preliminary data, we hypothesized modulation of FRY expression occurs through epigenetic mechanisms which include DNA methylation, histone modification and chromatin remodeling, and the activity/interaction of non-coding RNAs. To understand how DNA methylation regulates FRY transcription in
breast tumors, we examined publicly available RNA-seq and DNA methylation data from The
Cancer Genome Atlas (TCGA). Analysis of FRY promoter methylation revealed no significant changes in DNA methylation in normal vs.
breast tumors. However, when we subdivided the tumors by hormone receptor status, we observed an increase in FRY promoter methylation in ER- and PR-
breast tumors. Treatment of various
breast cancer cell lines with the DNMT inhibitor, 5-Aza-2-deoxycytidine, resulted in upregulation of FRY mRNA and protein expression. These results indicate that loss of FRY expression may in part be due to increased methylation. To elucidate the role of chromatin in the role of FRY expression we searched publicly available chromatin immunoprecipitation sequencing data from the Encyclopedia of DNA elements (ENCODE) to identify key chromatin markers and transcription factors that bind to the FRY promoter. Using this data, we demonstrated that FRY has a canonical gene promoter characterized by low levels of H3K4me1 and high levels H3K4me2/me3. Furthermore, using data from the ENCODE, we identified 28 transcription factors predicted to binds to the FRY gene promoter, the most significant of which were estrogen receptor 1 (ESR1) and progesterone receptor (PR). To determine if histone deacteylases (HDACs) impacted FRY expression, we dosed various
breast cancer cell lines with commonly used the HDAC inhibitors, Trichostatin-A and Panobinostat (LBH589). Through treatment of our cell lines with these HDAC inhibitors, we were able to modulate FRY expression, indicating that its expression is in part regulated by protein acetylation. Next, we explored whether transcriptional repressor, enhancer of Zeste Homolog 2…
Advisors/Committee Members: Zarbl, Helmut (chair), School of Graduate Studies.
Subjects/Keywords: Breast – Cancer
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Estrella, Brian, 1. (2018). Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/57543/
Chicago Manual of Style (16th Edition):
Estrella, Brian, 1989-. “Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene.” 2018. Doctoral Dissertation, Rutgers University. Accessed April 11, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/57543/.
MLA Handbook (7th Edition):
Estrella, Brian, 1989-. “Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene.” 2018. Web. 11 Apr 2021.
Vancouver:
Estrella, Brian 1. Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene. [Internet] [Doctoral dissertation]. Rutgers University; 2018. [cited 2021 Apr 11].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57543/.
Council of Science Editors:
Estrella, Brian 1. Epigenetic regulation of Fry: a mammary carcinoma susceptibility gene. [Doctoral Dissertation]. Rutgers University; 2018. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/57543/

Rutgers University
14.
Hemler, Jennifer R., 1972-.
Life with, after, or beyond cancer: breast cancer survivorship and the new normal.
Degree: PhD, Sociology, 2015, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/
► I examine how women “move on,” or are unable to, after a diagnosis of breast cancer. I interviewed 80 survivors of various types and stages…
(more)
▼ I examine how women “move on,” or are unable to, after a diagnosis of breast cancer. I interviewed 80 survivors of various types and stages of breast cancer to explore the relationship between how breast cancer survivors think about cancer and how they manage the daily consequences of this disease, including its effects on identity. My main objective was to examine the cognitive strategies and social practices survivors employ for living with (a history of having had) cancer. Cancer experience is undoubtedly shaped by factors like disease stage and type, treatments received, time since diagnosis and treatment, age, and social location. But many of my participants, across categories, described bracketing some aspects of their experience while holding onto a certain degree of ontological insecurity as they redefined their lives after, with, or beyond cancer. Drawing on ontological insecurity enabled them to remain attuned to their selves: they used cancer to help them redraw boundaries in their lives and focus attention on their selves in ways they were not doing previously. While self-regulatory health practices, feminist ideologies/the women’s health movement, and environmental awareness overlap in breast cancer survivorship to produce activated patients and actualized subjectivities, my participants also discussed how the existential and medical uncertainties of their experiences led them to create new spaces for meaning in their lives. However, while many of my participants wanted to use cancer as a catalyst for self-growth or change across life domains, certainly not all of them were able to do so. Survivorship programs are critical in this regard. They can help survivors harness the uncertainty they feel instead of allowing it to become paralyzing or debilitating. Many survivors need help framing ontological insecurity as a resource to employ, not something to move beyond; but, moreover, they need spaces in which they can acknowledge these uncertainties as part of their new realities.
Advisors/Committee Members: Cerulo, Karen A (chair), Carr, Deborah (internal member), Horwitz, Allan (internal member), Almeling, Rene (outside member).
Subjects/Keywords: Breast – Cancer; Breast cancer patients; Cancer – Patients
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Hemler, Jennifer R., 1. (2015). Life with, after, or beyond cancer: breast cancer survivorship and the new normal. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48509/
Chicago Manual of Style (16th Edition):
Hemler, Jennifer R., 1972-. “Life with, after, or beyond cancer: breast cancer survivorship and the new normal.” 2015. Doctoral Dissertation, Rutgers University. Accessed April 11, 2021.
https://rucore.libraries.rutgers.edu/rutgers-lib/48509/.
MLA Handbook (7th Edition):
Hemler, Jennifer R., 1972-. “Life with, after, or beyond cancer: breast cancer survivorship and the new normal.” 2015. Web. 11 Apr 2021.
Vancouver:
Hemler, Jennifer R. 1. Life with, after, or beyond cancer: breast cancer survivorship and the new normal. [Internet] [Doctoral dissertation]. Rutgers University; 2015. [cited 2021 Apr 11].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/.
Council of Science Editors:
Hemler, Jennifer R. 1. Life with, after, or beyond cancer: breast cancer survivorship and the new normal. [Doctoral Dissertation]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48509/
15.
Mukupo, Florence C.
Breast self examination practices among rural (Solwezi) and urban (Lusaka) women.
Degree: 2012, University of Zimbabwe
URL: http://dspace.unza.zm/handle/123456789/1445
► Breast cancer is a significant health threat for women and is currently the second- leading cause of cancer related deaths in women. Breast cancer is…
(more)
▼ Breast cancer is a significant health threat for women and is currently the second- leading cause of cancer related deaths in women. Breast cancer is the second most common cancer of women in Zambia. Breast cancer screening has been shown to reduce mortality. Thus early detection is crucial. World Health Organization does not recommend mammography screening in developing countries because it is not cost effective. Breast Self Examination (BSE) is an alternative method of screening for breast cancer. BSE is recommended for all women over the age of 20. Despite this recommendation, adherence to BSE guidelines is quite low. Study Design The purpose of the current study was to compare knowledge and use of BSE among rural and urban women. The study also sought to detect associations between the study variables. Study Setting
The study was conducted in Solwezi and Lusaka Districts. Sampling Simple random sampling was utilized to select the wards were the research was conducted. The using systematic sampling, households were selected. Then all women in childbearing age who met the inclusion criteria were interviewed. The age range was 15-49years because cancer of the breast has a high prevalence in this age group. A total of 238 respondents took part in the study. Instrument Data was collected using an interview schedule. Analysis Data analysis was done using EPI info statistical package.
Results:The study showed that most of the respondents, 58.2% from urban area and 81.9% from rural area had no knowledge on breast cancer. The study also showed that BSE knowledge was low among the respondents. The majority of the respondents 84.5% in rural and 64.7% from urban area had no knowledge on BSE.BSE practice results showed that the majority of the respondents were not practicing BSE. The study concluded that both the knowledge and practice of BSE were low in both rural and urban areas.The study recommended that Primary health care workers should be trained to teach Breast self-examination (BSE). The MoH/CBoH should develop teaching manuals for use by health providers during BSE teaching so that there is consistence and uniformity in BSE information to the women. The MoH/CBoH should ensure that nurses' knowledge and skill in BSE should be improved through re-training so that they could give expert instructions to women in relation to BSE technique. Breast Awareness, which is advocated in place of routine breast examination, should be encouraged among women. Health providers should continue to initiate discussions on BSE and the importance of periodic check up that include Clinical Breast Examination (CBE) for all women.Women should be taught to request for CBE even if their initial visit has nothing to do with clinical breast examination. Nurses teaching BSE must emphasize that early detection and treatment enhances survival. School Health Programs should include health education on breast cancer and BSE so that these educational programs on BSE start as early as 12 years of age, so that the girl child could start BSE early and…
Subjects/Keywords: Breast – Examination; Breast – Cancer – Zambia
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APA ·
Chicago ·
MLA ·
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CSE |
Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Mukupo, F. C. (2012). Breast self examination practices among rural (Solwezi) and urban (Lusaka) women. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/1445
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mukupo, Florence C. “Breast self examination practices among rural (Solwezi) and urban (Lusaka) women.” 2012. Thesis, University of Zimbabwe. Accessed April 11, 2021.
http://dspace.unza.zm/handle/123456789/1445.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mukupo, Florence C. “Breast self examination practices among rural (Solwezi) and urban (Lusaka) women.” 2012. Web. 11 Apr 2021.
Vancouver:
Mukupo FC. Breast self examination practices among rural (Solwezi) and urban (Lusaka) women. [Internet] [Thesis]. University of Zimbabwe; 2012. [cited 2021 Apr 11].
Available from: http://dspace.unza.zm/handle/123456789/1445.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mukupo FC. Breast self examination practices among rural (Solwezi) and urban (Lusaka) women. [Thesis]. University of Zimbabwe; 2012. Available from: http://dspace.unza.zm/handle/123456789/1445
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern California
16.
Liu, Chia-Wei.
Factors influencing the decision and timing to undergo
breast reconstruction after mastectomy for breast cancer in public
hospital vs. private medical center from 2007 to 2013: a
retrospective cohort study.
Degree: MS, Biostatistics, 2015, University of Southern California
URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/553067/rec/2735
► Background/Objective: This study was performed to compare the rates of breast reconstruction between a public safety‐net hospital (LA County Medical Center (LAC)) vs. a academic…
(more)
▼ Background/Objective: This study was performed to
compare the rates of
breast reconstruction between a public
safety‐net hospital (LA County Medical Center (LAC)) vs. a academic
medical center (Keck Hospital of USC/Norris
Cancer Center
(Keck/Norris)), with emphasis on immediate
breast reconstruction
(IBR). We hypothesized that both overall reconstruction rate (the
proportion of patients receiving reconstruction among the total
patients having mastectomy) and the IBR rate (the proportion of
patients receiving IBR among the total patients having
reconstruction) were higher at Keck/Norris than LAC. We also aimed
to explore the factors that were associated with overall
reconstruction rate or IBR rate, and to estimate the time to
reconstruction and the fraction of patients who would not undergo
delayed
breast reconstruction (cure fraction). ❧ Methods: We
retrospectively collected all the data of patients with stage 0 –
III
breast cancer who received mastectomy during Jan 2006 to Dec
2013 from Keck/Norris and LAC. Univariate and multivariate logistic
regressions were performed to compare the IBR rate and overall
reconstruction rate between the two institutions, as well as to
evaluate the correlation between IBR rate or overall reconstruction
rate with various factors. Kaplan‐Meier method was used to
scrutinize the time to reconstruction, and non‐mixture cure
fraction model was performed for estimating the cure fraction. ❧
Results: Of the 453 patients, 327 patients were from LAC and 126
were from Keck/Norris. The odds ratio (OR) of reconstruction rate
was 2.2 at Keck/Norris compared to LAC (p < 0.001) without
adjustment for patient demographic factors, but was no longer
significant with adjustment. The OR of IBR rate was 21.2 compared
from Keck/Norris to LAC (p < 0.001) without adjustment for
patient demographic factors, and was 22.3 with adjustment (p <
0.001). Based on the p < 0.25 entry criteria, factors that we
kept in the multivariate overall reconstruction rate model were
insurance status (p < 0.001), race (p < 0.05), age (p <
0.001), BMI (p < 0.05), smoking status (p = 0.08), occupation
status (p = 0.18), personal history of other
cancer (p = 0.12),
progesterone receptor (PR) status (p = 0.22) and radiotherapy (p
< 0.001). For IBR rate we had institution (p < 0.001), BMI (p
= 0.21), clinical stage (p < 0.01) and radiotherapy (p <
0.01) in the model. The Kaplan‐Meier curves revealed that more
patients underwent IBR at Keck/Norris than at LAC. Excluding the
IBR patients, the average time to reconstruction at Keck/Norris was
20.3 ± 0.47 (SE) months, and was 37.4 ± 0.91 (SE) months at LAC.
The estimated cure fractions were 0.71 and 0.99 at LAC and
Keck/Norris, respectively. The factors that we kept in the
multivariate non‐mixture cure fraction model were institution (p
< 0.01), insurance status (p < 0.05), age = (p < 0.001),
smoking status (p = 0.10), occupation status (p = 0.062), clinical
stage (p = 0.12), PR status (p < 0.05). ❧ Conclusions: The
reconstruction rate did not differ between these two institutions,
but…
Advisors/Committee Members: Sposto, Richard (Committee Chair), Mack, Wendy Jean (Committee Member), Groshen, Susan L. (Committee Member).
Subjects/Keywords: breast cancer; mastectomy; breast reconstruction
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Liu, C. (2015). Factors influencing the decision and timing to undergo
breast reconstruction after mastectomy for breast cancer in public
hospital vs. private medical center from 2007 to 2013: a
retrospective cohort study. (Masters Thesis). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/553067/rec/2735
Chicago Manual of Style (16th Edition):
Liu, Chia-Wei. “Factors influencing the decision and timing to undergo
breast reconstruction after mastectomy for breast cancer in public
hospital vs. private medical center from 2007 to 2013: a
retrospective cohort study.” 2015. Masters Thesis, University of Southern California. Accessed April 11, 2021.
http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/553067/rec/2735.
MLA Handbook (7th Edition):
Liu, Chia-Wei. “Factors influencing the decision and timing to undergo
breast reconstruction after mastectomy for breast cancer in public
hospital vs. private medical center from 2007 to 2013: a
retrospective cohort study.” 2015. Web. 11 Apr 2021.
Vancouver:
Liu C. Factors influencing the decision and timing to undergo
breast reconstruction after mastectomy for breast cancer in public
hospital vs. private medical center from 2007 to 2013: a
retrospective cohort study. [Internet] [Masters thesis]. University of Southern California; 2015. [cited 2021 Apr 11].
Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/553067/rec/2735.
Council of Science Editors:
Liu C. Factors influencing the decision and timing to undergo
breast reconstruction after mastectomy for breast cancer in public
hospital vs. private medical center from 2007 to 2013: a
retrospective cohort study. [Masters Thesis]. University of Southern California; 2015. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/553067/rec/2735

University of New South Wales
17.
Kalyuga , Maria.
Exploration of the role of the ETS transcription factor ESE2 in breast cancer.
Degree: Clinical School - St Vincent's Hospital, 2011, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/51251
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9903/SOURCE02?view=true
► Thesis abstract: Breast cancer represents a leading cancer-related diagnosis of Australian women, with treatments ultimately still ineffective for many patients. Investigating the mechanisms behind normal…
(more)
▼ Thesis abstract:
Breast cancer represents a leading
cancer-related diagnosis of Australian women, with treatments ultimately still ineffective for many patients. Investigating the mechanisms behind normal
breast development is a means to identify processes involved in carcinogenesis, as they are frequently corrupted to facilitate tumour initiation and progression. The PRL signaling pathway is vital for the function of the mammary tissue during pregnancy and lactation. The mouse ELF5 and its human counterpart, ESE2, were identified as downstream targets of this pathway and have subsequently been characterised as crucial players in mammary gland development. In addition, limited evidence has pointed to the possibility of this protein being involved in human
breast carcinogenesis, although a direct link remains pending. The current body of work was aimed at exploring the role of the human ESE2 in
breast cancer. This was achieved through the use of a range of large and small-scale in vitro techniques to, firstly, attempt to identify potential ESE2 binding partners. Secondly, a model of inducible, stable ESE2 downregulation was employed to establish the function of ESE2 in the T47D
breast cancer cell line, in the context of progesterone signaling, which is an important mediator of normal and aberrant mammary gland behaviour. It was determined that inhibiting a progestin-mediated ESE2 increase led to the augmentation of the previously characterised anti-proliferative effects of this hormone. An equivalent overexpression model was generated and characterised in detail. Negative effects of ESE2 on cell proliferation and adhesion were identified and were accompanied by changes at the level of apoptosis, gene transcription activity and other molecular changes. The data gathered is the first study to directly examine the role of ESE2 in human
breast cancer.
Advisors/Committee Members: Ormandy, Christopher , Clinical School - St Vincent's Hospital, Faculty of Medicine, UNSW.
Subjects/Keywords: Breast cancer; Human breast carcinogenesis
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Kalyuga , M. (2011). Exploration of the role of the ETS transcription factor ESE2 in breast cancer. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/51251 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9903/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Kalyuga , Maria. “Exploration of the role of the ETS transcription factor ESE2 in breast cancer.” 2011. Doctoral Dissertation, University of New South Wales. Accessed April 11, 2021.
http://handle.unsw.edu.au/1959.4/51251 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9903/SOURCE02?view=true.
MLA Handbook (7th Edition):
Kalyuga , Maria. “Exploration of the role of the ETS transcription factor ESE2 in breast cancer.” 2011. Web. 11 Apr 2021.
Vancouver:
Kalyuga M. Exploration of the role of the ETS transcription factor ESE2 in breast cancer. [Internet] [Doctoral dissertation]. University of New South Wales; 2011. [cited 2021 Apr 11].
Available from: http://handle.unsw.edu.au/1959.4/51251 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9903/SOURCE02?view=true.
Council of Science Editors:
Kalyuga M. Exploration of the role of the ETS transcription factor ESE2 in breast cancer. [Doctoral Dissertation]. University of New South Wales; 2011. Available from: http://handle.unsw.edu.au/1959.4/51251 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:9903/SOURCE02?view=true

Delft University of Technology
18.
Janssen, Ernest (author).
Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system.
Degree: 2019, Delft University of Technology
URL: http://resolver.tudelft.nl/uuid:32ca7acd-c89c-43b6-8576-2d5181995d50
► Breast cancer is impacting over 1.5 million women each year. Early detection is essential in decreasing the mortality rate. Mammography is currently the golden standard…
(more)
▼ Breast cancer is impacting over 1.5 million women each year. Early detection is essential in decreasing the mortality rate. Mammography is currently the golden standard for breast screening. However, this method is not ideal and water-bath ultrasound breast scanning is considered to be a promising screening modality. This type of scanning system is able to obtain ultrasound reflection and transmission data. In this study, a water-cup breast scanning setup is built. The setup consists of a plastic cup with four acoustic windows and four phased array ultrasound probes. The water-cup is used to execute a phantom study. The phantom study gives insight into the operability of the built water-cup. The differences between reflection and transmission data are observed and utilised. One imaging algorithm and two inversion algorithms are employed to reconstruct an image of the phantom. The images of the different algorithms are compared. Furthermore, a method is proposed that reduces the computation time of a reflection data based Born inversion algorithm. In the end, the water-cup is used to image an ex-vivo human breast. Finally, the limitations of the built water-cup are stated. In addition to manufacturing the water-cup, a pulse-echo-scan of an ex-vivo human breast is made. This pulse-echo-scan is compared with the cross-sectional photograph of the breast. Due to the pudding-like structure of the breast, it is challenging to make a cross-section at the same position as the pulse-echo-scan is made. The pulse-echo-scan is made at the Pathology Department of the Erasmus MC. The ex-vivo human breast study helps to understand what structures are present in the breast. This knowledge can be used to build a new measurement setup and optimize the imaging algorithms for finding tumours.
Delft Breast Ultrasound
Advisors/Committee Members: van Dongen, K.W.A. (mentor), Taskin, U. (graduation committee), Delft University of Technology (degree granting institution).
Subjects/Keywords: Breast cancer; Ultrasound; Breast scanning
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Janssen, E. (. (2019). Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:32ca7acd-c89c-43b6-8576-2d5181995d50
Chicago Manual of Style (16th Edition):
Janssen, Ernest (author). “Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system.” 2019. Masters Thesis, Delft University of Technology. Accessed April 11, 2021.
http://resolver.tudelft.nl/uuid:32ca7acd-c89c-43b6-8576-2d5181995d50.
MLA Handbook (7th Edition):
Janssen, Ernest (author). “Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system.” 2019. Web. 11 Apr 2021.
Vancouver:
Janssen E(. Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system. [Internet] [Masters thesis]. Delft University of Technology; 2019. [cited 2021 Apr 11].
Available from: http://resolver.tudelft.nl/uuid:32ca7acd-c89c-43b6-8576-2d5181995d50.
Council of Science Editors:
Janssen E(. Delft Breast Ultrasound: The development of a water-cup ultrasound breast scanning system. [Masters Thesis]. Delft University of Technology; 2019. Available from: http://resolver.tudelft.nl/uuid:32ca7acd-c89c-43b6-8576-2d5181995d50

Oregon State University
19.
Everson, Courtney Louise.
Reproductive decision-making in young women breast cancer survivors.
Degree: MA, Applied Anthropology, 2009, Oregon State University
URL: http://hdl.handle.net/1957/10010
► The purpose of this study is to use an integrated biocultural perspective to examine the decision-making processes of young survivors as they navigate breast cancer…
(more)
▼ The purpose of this study is to use an integrated biocultural perspective to examine the decision-making processes of young survivors as they navigate
breast cancer treatment and reproductive health care options. This retrospective study utilizes a mixed-methods approach that integrates quantitative survey data (Phase I) with interview (Phase II) and focus group (Phase III) narratives from the young survivor community. Grounded theory and biocultural approaches guide analysis and interpretations. Findings reveal how young women engage reproductive and treatment decision-making as biocultural beings, negotiating immediate mortality risks, institutional constraints, and long-term, quality of life concerns and reproductive health values. Recommendations include the integration of women's voices and biocultural approaches into the development of young survivor educational materials and
cancer care counseling in an effort to establish a successful shared decision-making model as the clinical standard.
Advisors/Committee Members: Cheyney, Melissa J (advisor), Khanna, Sunil (committee member).
Subjects/Keywords: breast cancer; Breast – Cancer – Patients – Decision making
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Everson, C. L. (2009). Reproductive decision-making in young women breast cancer survivors. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/10010
Chicago Manual of Style (16th Edition):
Everson, Courtney Louise. “Reproductive decision-making in young women breast cancer survivors.” 2009. Masters Thesis, Oregon State University. Accessed April 11, 2021.
http://hdl.handle.net/1957/10010.
MLA Handbook (7th Edition):
Everson, Courtney Louise. “Reproductive decision-making in young women breast cancer survivors.” 2009. Web. 11 Apr 2021.
Vancouver:
Everson CL. Reproductive decision-making in young women breast cancer survivors. [Internet] [Masters thesis]. Oregon State University; 2009. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/1957/10010.
Council of Science Editors:
Everson CL. Reproductive decision-making in young women breast cancer survivors. [Masters Thesis]. Oregon State University; 2009. Available from: http://hdl.handle.net/1957/10010

University of Johannesburg
20.
Minnaar, Carrie-Anne.
The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment.
Degree: 2010, University of Johannesburg
URL: http://hdl.handle.net/10210/3161
► M. Tech.
AIM: To determine the efficacy of Astragalus membranaceous tincture at maintaining the circulating white blood cell count (WBC) and absolute neutrophil count (ANC)…
(more)
▼ M. Tech.
AIM: To determine the efficacy of Astragalus membranaceous tincture at maintaining the circulating white blood cell count (WBC) and absolute neutrophil count (ANC) of breast cancer patients receiving chemotherapy. METHODS: This is an open-label study with an active control group. Both the study and control group consisted of fifteen participants. The participants in the study group each received ten millilitres of Astragalus membranaceous 1:2 tincture daily for the duration of their course of chemotherapy. RESULTS: The overall decrease in the WBC and ANC in the control was 4.9 and 3.13 parts per billion per litre, respectively. The study group showed an overall decrease of 2.7 and 1.9 parts per billion per litre, respectively. The average overall reduction in chemotherapy dose was 4.79 percent in the study group and 20.21 percent in the control. In all of the analyses p > 0.05. The small sample size, poor patient compliance and skewed distribution of the variables hindered the reliability of the results. CONCLUSION: The positive effects observed in the study group cannot be extrapolated to the entire population, however further research is strongly motivated.
Subjects/Keywords: Breast cancer chemotherapy; Breast cancer treatment
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Minnaar, C. (2010). The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/3161
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Minnaar, Carrie-Anne. “The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment.” 2010. Thesis, University of Johannesburg. Accessed April 11, 2021.
http://hdl.handle.net/10210/3161.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Minnaar, Carrie-Anne. “The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment.” 2010. Web. 11 Apr 2021.
Vancouver:
Minnaar C. The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment. [Internet] [Thesis]. University of Johannesburg; 2010. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10210/3161.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Minnaar C. The efficacy of astragalus membranaceous tincture at maintaining the circulating leucocyte and absolute neutrophil counts of breast cancer patients undergoing chemotherapeutic treatment. [Thesis]. University of Johannesburg; 2010. Available from: http://hdl.handle.net/10210/3161
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of the Western Cape
21.
Janodien, Fatima.
Proteome signature of breast cancer cells treated with fucoidan
.
Degree: 2016, University of the Western Cape
URL: http://hdl.handle.net/11394/5315
► Breast cancer is responsible for a large portion of cancer-related deaths. Worldwide, incidence is increasing. Routinely-used treatments for breast cancer are invasive and are associated…
(more)
▼ Breast cancer is responsible for a large portion of
cancer-related deaths. Worldwide, incidence is increasing. Routinely-used treatments for
breast cancer are invasive and are associated with a range of side-effects which may affect quality of life. Fucoidan, a marine bioactive compound, found primarily in brown seaweed, has various medicinal qualities. Among its bioactivities studied, it has potent anticancer activity. Despite numerous studies, the mechanism of action of fucoidan on
cancer cells remains unclear. This project aims to shed light on the mechanism of action of fucoidan by studying its effect on the MCF7
breast cancer cell proteome. The IC50 obtained for fucoidan treated MCF7 cells was 0.2 mg/ml. Decrease in expression of XIAP and phosphorylation of ERK1/2 was observed, indicating a decrease in inhibition of apoptosis and increased sensitivity to apoptosis, respectively. Literature reports activation of several caspases, including caspase-3, in various cell lines after to fucoidan treatment. Taken together, with data from the current study it can be said that fucoidan treatment led to cell death by apoptosis. SILAC analysis identified over 2000 proteins with more than 1700 at 95% confidence. STRING analysis of enriched proteins revealed 19 cell death related proteins. However, SILAC results were ambiguous with regards to differential protein regulation and should be repeated with lower electrospray ionization flow rates, pairwise and single sample runs, and validation with Western blot analysis of various apoptosis related proteins and biochemical assays.
Advisors/Committee Members: Bauer, Rolene (advisor), Meyer, Mervin (advisor).
Subjects/Keywords: Breast – Cancer – Treatment;
Breast cancer;
Fucoidan
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Janodien, F. (2016). Proteome signature of breast cancer cells treated with fucoidan
. (Thesis). University of the Western Cape. Retrieved from http://hdl.handle.net/11394/5315
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Janodien, Fatima. “Proteome signature of breast cancer cells treated with fucoidan
.” 2016. Thesis, University of the Western Cape. Accessed April 11, 2021.
http://hdl.handle.net/11394/5315.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Janodien, Fatima. “Proteome signature of breast cancer cells treated with fucoidan
.” 2016. Web. 11 Apr 2021.
Vancouver:
Janodien F. Proteome signature of breast cancer cells treated with fucoidan
. [Internet] [Thesis]. University of the Western Cape; 2016. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/11394/5315.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Janodien F. Proteome signature of breast cancer cells treated with fucoidan
. [Thesis]. University of the Western Cape; 2016. Available from: http://hdl.handle.net/11394/5315
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Delaware
22.
LoSavio, Stefanie T.
Construct validity of fear of recurrence among breast cancer survivors.
Degree: PhD, University of Delaware, Department of Psychological and Brain Sciences, 2015, University of Delaware
URL: http://udspace.udel.edu/handle/19716/17447
► Advancements in cancer detection and treatment have improved the life expectancy of today's cancer patients. With patients living longer, many are now facing the challenges…
(more)
▼ Advancements in
cancer detection and treatment have improved the life expectancy of today's
cancer patients. With patients living longer, many are now facing the challenges of survivorship. One of the most commonly reported problems among
cancer survivors is fear of recurrence. Despite a recent proliferation of literature in the area of fear of recurrence, little theoretical and empirical work has been conducted to define and establish the validity of this important construct. To address this gap in the literature, we proposed and tested a cognitive-emotional theory of fear of recurrence. We then evaluated the convergent, discriminant, and concurrent validity of the theory-consistent items. Three hundred early stage
breast cancer survivors completed measures of fear of recurrence,
cancer-relevant behavioral outcomes (e.g., health care utilization, functional impairment), and other theoretically-related but distinct constructs (e.g., uncertainty intolerance, general health anxiety). We employed sophisticated structural equation modeling techniques to test our theory of fear of recurrence and evaluate its construct validity. Overall, we found support for our hypothesis that fear of recurrence is a unique construct with predictive power. We hope that findings from this study will expand the theoretical basis for fear of recurrence and serve as a foundation for continued research on this important construct.
Advisors/Committee Members: Laurenceau, Jean-Philippe.
Subjects/Keywords: Breast – Cancer – Patients.; Breast – Cancer – Relapse.; Fear.
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
LoSavio, S. T. (2015). Construct validity of fear of recurrence among breast cancer survivors. (Doctoral Dissertation). University of Delaware. Retrieved from http://udspace.udel.edu/handle/19716/17447
Chicago Manual of Style (16th Edition):
LoSavio, Stefanie T. “Construct validity of fear of recurrence among breast cancer survivors.” 2015. Doctoral Dissertation, University of Delaware. Accessed April 11, 2021.
http://udspace.udel.edu/handle/19716/17447.
MLA Handbook (7th Edition):
LoSavio, Stefanie T. “Construct validity of fear of recurrence among breast cancer survivors.” 2015. Web. 11 Apr 2021.
Vancouver:
LoSavio ST. Construct validity of fear of recurrence among breast cancer survivors. [Internet] [Doctoral dissertation]. University of Delaware; 2015. [cited 2021 Apr 11].
Available from: http://udspace.udel.edu/handle/19716/17447.
Council of Science Editors:
LoSavio ST. Construct validity of fear of recurrence among breast cancer survivors. [Doctoral Dissertation]. University of Delaware; 2015. Available from: http://udspace.udel.edu/handle/19716/17447

Columbia University
23.
Putcha, Preeti.
HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers.
Degree: 2015, Columbia University
URL: https://doi.org/10.7916/D81835KX
► Inflammatory Breast Cancer (IBC) is a rare, lethal, and understudied form of breast cancer. Although affecting 1-2% of the population, the remission rate is half…
(more)
▼ Inflammatory Breast Cancer (IBC) is a rare, lethal, and understudied form of breast cancer. Although affecting 1-2% of the population, the remission rate is half that of the spectrum of other breast cancers, and most cases present in the advanced stages due to rapid undetectable development. Of the diagnosed cases, systemic chemotherapeutics are relatively ineffective in comparison to non-IBC breast cancer cases, indicating other unique mechanisms driving IBC progression. Historically, the specific sensitivities of a particular tumor type or subtype have been linked to genetic alterations that represent addiction hubs, such as hyperactivation of oncogenes due to mutation.
Although some efforts have been made to characterize the molecular fingerprint of inflammatory breast cancers (IBCs), unfortunately, no clinical application has emerged from these studies. Thus, we decided to utilize a different strategy to identify the Achilles' heel of IBC cells. Using shRNA libraries, we performed an unbiased genome-wide loss-of-function screen comparing the gene functions required for survival of IBC and non-IBC cells. Histone deacetylase 6 (HDAC6) emerged as one of the top genes required for IBC cell survival and was further validated.
HDAC6 is vital in the cell's unfolded protein response (UPR) to clear misfolded or toxic protein, and IBC cells proved to be preferentially sensitive to this aspect of HDAC6 inhibition, displaying increased protein accumulation, ER stress indicators, and subsequent apoptosis upon failure to clear or refold accumulated proteins. These data indicate HDAC6 is a crucial gene required for IBC cell line survival, in part due to its function in IBC cell UPR. Furthermore, emerging orally bioavailable agents for HDAC6 inhibition make it a promising candidate towards tailored therapeutic implementation in IBC patient trials.
Subjects/Keywords: Pathology; Cytology; Breast – Cancer; Breast – Cancer – Treatment
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APA (6th Edition):
Putcha, P. (2015). HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D81835KX
Chicago Manual of Style (16th Edition):
Putcha, Preeti. “HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers.” 2015. Doctoral Dissertation, Columbia University. Accessed April 11, 2021.
https://doi.org/10.7916/D81835KX.
MLA Handbook (7th Edition):
Putcha, Preeti. “HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers.” 2015. Web. 11 Apr 2021.
Vancouver:
Putcha P. HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers. [Internet] [Doctoral dissertation]. Columbia University; 2015. [cited 2021 Apr 11].
Available from: https://doi.org/10.7916/D81835KX.
Council of Science Editors:
Putcha P. HDAC6 as a novel candidate in the treatment of Inflammatory Breast Cancers. [Doctoral Dissertation]. Columbia University; 2015. Available from: https://doi.org/10.7916/D81835KX

Boston University
24.
Lee, Tian Yu.
The role and function of SOX11 in DNA damage in triple-negative breast cancer.
Degree: MS, Medical Sciences, 2019, Boston University
URL: http://hdl.handle.net/2144/36570
► Breast cancer is a complex heterogenous disease that consists of several different subtypes displaying distinct behaviors and responses to different treatments. It is the second…
(more)
▼ Breast cancer is a complex heterogenous disease that consists of several different subtypes displaying distinct behaviors and responses to different treatments. It is the second leading cause of
cancer death among women, and is the most commonly diagnosed
cancer in women. Although recent developments have helped shed light into this disease, there is still much to investigate. One particular subtype of
breast cancer, known as triple-negative
breast cancer, remains the most aggressive, as this tumor type is of high histological grade and preferentially affects women with BRCA1 mutations and women who are younger than 40 years of age. Unlike other subtypes with better prognoses, triple-negative
breast cancer still has no targeted therapy, and chemotherapy remains the primary systemic treatment.
Recently, there has been an increase of interest in the SOXC family of high mobility group transcription factors and their roles in tumor development. Studies have revealed some of the effects that SOXC genes may have on various tumor types. However, further studies are still needed to elucidate the roles, functions, regulations, and mechanisms of these transcription factors. This study aims to focus on one particular gene in the SOXC family known as sex determining region Y-box 11. Recent studies have shown that sex determining region Y-box 11, also known as SOX11, is one of the factors required for maintaining the basal-like
breast cancer phenotype and is also critical in regulating growth, migration, invasion, and expression of signature basal-like
breast cancer genes. Emerging evidence also reveals that this transcription factor may have an impact on homologous recombination repair when DNA damage occurs, in triple-negative
breast cancer.
Using SOX11 overexpression and knockout cell models combined with basic science laboratory techniques and omics, the next generation of laboratory tools, this study seeks to explore the role and function of SOX11 in DNA damage in triple-negative
breast cancer.
The results of this study have confirmed the recent findings of the role of SOX11 in cell proliferation and growth in triple-negative
breast cancer. It has also revealed that overexpression of SOX11 in triple-negative
breast cancer cell lines leads to an increase in DNA damage, loss of BRCA1 function, and dysregulation in the cell cycle. High expression of SOX11 is also associated with worse prognostic outcomes in triple-negative
breast cancer patients. Because overexpression of SOX11 resulted in a loss of BRCA1 function, there may be a potential role for SOX11 in inducing the BRCAness phenotype commonly seen in basal-like
breast cancers. The results of this study strongly suggest that SOX11 is involved in defective DNA damage repair pathways. Further studies need to be conducted in order to evaluate SOX11 as an inducer of the BRCAness phenotype, which occurs when there is a homologous recombination repair defect and no germline BRCA1 mutation present. Because of this, SOX11 may also have the potential to act as a functional…
Advisors/Committee Members: Cui, Xiaojiang (advisor).
Subjects/Keywords: Oncology; Breast cancer; Triple-negative breast cancer
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lee, T. Y. (2019). The role and function of SOX11 in DNA damage in triple-negative breast cancer. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/36570
Chicago Manual of Style (16th Edition):
Lee, Tian Yu. “The role and function of SOX11 in DNA damage in triple-negative breast cancer.” 2019. Masters Thesis, Boston University. Accessed April 11, 2021.
http://hdl.handle.net/2144/36570.
MLA Handbook (7th Edition):
Lee, Tian Yu. “The role and function of SOX11 in DNA damage in triple-negative breast cancer.” 2019. Web. 11 Apr 2021.
Vancouver:
Lee TY. The role and function of SOX11 in DNA damage in triple-negative breast cancer. [Internet] [Masters thesis]. Boston University; 2019. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/2144/36570.
Council of Science Editors:
Lee TY. The role and function of SOX11 in DNA damage in triple-negative breast cancer. [Masters Thesis]. Boston University; 2019. Available from: http://hdl.handle.net/2144/36570

University of Illinois – Chicago
25.
Tossas-Milligan, Katherine Y.
The Influence of Mammographic Density on Breast Cancer Risk.
Degree: 2018, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/22959
► High mammographic breast density (HBD) is a well-established risk factor for increased breast cancer (BC) incidence (1-4) and later stage of breast cancer diagnosis (5,…
(more)
▼ High mammographic
breast density (HBD) is a well-established risk factor for increased
breast cancer (BC) incidence (1-4) and later stage of
breast cancer diagnosis (5, 6). Mechanistically, HBD may mask BC at screening and result in interval BC being diagnosed at a later stage (5, 7-12). Biologically, HBD may be associated with increased cell proliferation and a general increase in mitogenic factors (13). However, the biological mechanisms through which HBD may operate to increase BC risk are not clearly defined, and its potential role in tumor progression and BC aggressiveness remains a debated issue.
Given that most of the conclusions with regards to HBD and BC risk are based on primarily monoracial (non-Latina White women) studies, not much is known regarding if HBD affects women across various races and ethnicities differently. These racial/ethnic differences are particularly relevant within the context of existing racial/ethnic
breast cancer mortality disparities in the United States where non-Latina Black (NLB) women, despite their lower BC incidence, are more likely to die from the disease compared to their non-Latina White (NLW) counterparts (14-17). While differential access to care, comorbidities, and BC aggressiveness are suggested in the literature as contributors to this difference (18-24), the potential impact of
breast density on this disparity has not been explored. Understanding the effects of HBD on BC risk in a diverse cohort would add to the scarce literature regarding the effect of HBD across various race/ethnicities.
In this dissertation, the researcher proposes to explore whether
breast density differs across racial/ethnic groups and what factors may account for these differences. Additionally, the researcher proposes to explore the association between high
breast density and
breast cancer incidence, aggressiveness, and stage at diagnosis in a cohort of diverse women presenting for
breast cancer screening at a large healthcare network in Metropolitan Chicago, with the following aims:
Aim 1: To explore how
breast density (BD) may differ by race/ethnicity and other individual level factors (BMI, age, hormonal)
Aim 2: To explore if BD impacts
breast cancer (BC) risk by subtype
Aim 3: To explore potential mechanisms through which BD influences
breast cancer stage at diagnosis
Advisors/Committee Members: Rauscher, Garth H (advisor), Campbell, Richard (committee member), Seewaldt, Victoria (committee member), Friedewald, Sarah (committee member), Hoskins, Kent (committee member), Rauscher, Garth H (chair).
Subjects/Keywords: breast cancer risk; breast density; breast cancer disparities; breast density epidemiology
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APA ·
Chicago ·
MLA ·
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CSE |
Export
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Manager
APA (6th Edition):
Tossas-Milligan, K. Y. (2018). The Influence of Mammographic Density on Breast Cancer Risk. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22959
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tossas-Milligan, Katherine Y. “The Influence of Mammographic Density on Breast Cancer Risk.” 2018. Thesis, University of Illinois – Chicago. Accessed April 11, 2021.
http://hdl.handle.net/10027/22959.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tossas-Milligan, Katherine Y. “The Influence of Mammographic Density on Breast Cancer Risk.” 2018. Web. 11 Apr 2021.
Vancouver:
Tossas-Milligan KY. The Influence of Mammographic Density on Breast Cancer Risk. [Internet] [Thesis]. University of Illinois – Chicago; 2018. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10027/22959.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tossas-Milligan KY. The Influence of Mammographic Density on Breast Cancer Risk. [Thesis]. University of Illinois – Chicago; 2018. Available from: http://hdl.handle.net/10027/22959
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
26.
Lopez Almeida, Leonor.
Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells.
Degree: Docteur es, Pathologie humaine. Oncologie, 2017, Aix Marseille Université
URL: http://www.theses.fr/2017AIXM0653
► Les chiffres mondiaux estiment l’incidence du cancer du sein, cancer féminin le plus fréquent, à 1.3 millions de cas par an, dont près d’un tiers…
(more)
▼ Les chiffres mondiaux estiment l’incidence du cancer du sein, cancer féminin le plus fréquent, à 1.3 millions de cas par an, dont près d’un tiers a une issue fatale.La polarité est indispensable à l’organisation cellulaire, ses défauts peuvent mener au cancer. Notre projet est focalisé sur une protéine de la polarité, Lano, et son influence sur le cancer du sein et les CSC. L’Institut Paoli-Calmettes dispose d’environ 10000 échantillons de cancer du sein dont l’analyse montre que la perte de Lano est corrélée à des cancers du sein plus graves et à une augmentation des CSC. Nos résultats in vitro, sur des cellules de cancer du sein humain et in vivo montrent aussi que Lano est un régulateur du nombre de CSC. Les CSC sont une ces causes principales de rechute des patients. La suite de nos travaux pourrait déterminer si Lano est un facteur pronostique de la maladie ou une cible thérapeutique possible.
Breast cancer is the most common cancer in women. Worldwide figures estimate the incidence of breast cancer at 1.3 million cases per year, nearly one third of them has a fatal outcome.Our project focuses on the study of Lano, a polarity protein, in breast cancer and stem cells. The hospital “Institute Paoli-Calmettes” gathered 10,000 breast cancer samples whose analysis shows that the loss of Lano has a role in breast cancer and stem cells. Our in vitro results on human breast cancer cells and in vivo also show that Lano is a regulator of the number of cancer stem cells. Cancer stem cells are one of the major causes of relapse in patients. The rest of our work could determine if Lano could be a prognostic factor of the disease or a possible therapeutic target.
Advisors/Committee Members: Santoni, Marie-Josée (thesis director).
Subjects/Keywords: Cancer du sein; Breast cancer
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lopez Almeida, L. (2017). Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2017AIXM0653
Chicago Manual of Style (16th Edition):
Lopez Almeida, Leonor. “Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells.” 2017. Doctoral Dissertation, Aix Marseille Université. Accessed April 11, 2021.
http://www.theses.fr/2017AIXM0653.
MLA Handbook (7th Edition):
Lopez Almeida, Leonor. “Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells.” 2017. Web. 11 Apr 2021.
Vancouver:
Lopez Almeida L. Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells. [Internet] [Doctoral dissertation]. Aix Marseille Université 2017. [cited 2021 Apr 11].
Available from: http://www.theses.fr/2017AIXM0653.
Council of Science Editors:
Lopez Almeida L. Rôle de Lano/LRRC1 dans le cancer du sein et influence sur les cellules souches cancéreuses : Role of Lano/LRRC1 in breast cancer and influence in cancer stem cells. [Doctoral Dissertation]. Aix Marseille Université 2017. Available from: http://www.theses.fr/2017AIXM0653

University of Plymouth
27.
Al-Thamiree, Safaa Salman Mezban.
Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis.
Degree: PhD, 2019, University of Plymouth
URL: http://hdl.handle.net/10026.1/13585
► The effect of phytoestrogens on breast and prostate cancer cell lines - potential implications for bone preferential metastasis to bone Safaa Salman Mezban AL-Thamiree Abstract…
(more)
▼ The effect of phytoestrogens on breast and prostate cancer cell lines - potential implications for bone preferential metastasis to bone Safaa Salman Mezban AL-Thamiree Abstract Many epidemiological studies indicate that diets rich in phytoestrogens (PE), especially soy and grain products, may be associated with a lower risk of some steroid hormone-dependent cancers such as breast and prostate. In particular PE have been shown to reduce the incidence of skeletal metastasis which have a high degree of morbidity and mortality. However, the most effective combinations of PEs and the mechanism through which they may reduce bone metastasis remain unclear. Therefore, this study aims to establish the most effective combinations of common dietary PE on breast and prostate cancer line proliferation, motility, and expression of genes implicated in disease progression and preferential metastasis to the skeleton. The potential modifying effect of cytokines that tumour cells are exposed to in the bone micro environment will also be studied including TGF-β, BMP7 and IL-33. Results showed that phytoestrogens genistein and daidzein significantly reduced prostate cancer cell viability (PC3 cells) with concentration 10-7 M (15 %, P = 0.01) and 10-6 M (11%, P = 0.04) for genistein and for daidzein the decrease in cell number was (18%, P value = 0.04) for 10-8 M and (22 %, P = 0.01) for 10-7 M. In breast cancer cell line (MCF7) genistein and coumestrol showed a significant decrease in cell number while daidzein did not. The decrease in (MCF7) cell number with genistein was (15 %, P = 0.04) and (25 %, P = 0.04) for 10-6 M and 10-5 M respectively, while in coumestrol concentrations 10-7 , 10-6 and 10-5 M showed the most significant decrease in cell number and were (29 %, P = 0.03), (34 %, P= 0.01) and (37%, value = 0.007) respectively. Motility results showed no significant reduction in the closure time of the scratch in both cell lines and there was an acceleration in the healing time of the scratch in both cell lines but was significant only in breast cell line (MCF7) with coumestrol after 6 ,12 and 24 hours at concentrations between (10-9 - 10-5 M). Non-selective oestrogen receptor modulator (ICI 182,780) abolishes the effect of genistein (10-7 and 10-6 M) and daidzein (10-8 and 10-7 M) reduction in cell viability and increased PC3 cell numbers significantly. In MCF7 cells, (ICI 182,780) also abolished the effect of coumestrol and genistein and increased the cell numbers but not to a significant levels. While genistein, daidzein and coumestrol reduced breast and prostate cell viability individually in an oestrogen receptor dependent manner and this beneficial effect is lost when the effective concentrations are combined. Although, transforming growth factor β (TGFβ), shows antagonist effect on phytoestrogens induced changes when combined with (daidzein and genistein) and blocks any effect of PEs and increase collagen type I gene expression. In MCF7 cells, the non-inhibitory effect of individual genistein on PTHrP is lost in the presence…
Subjects/Keywords: phytoestrogens; breast cancer; prostate cancer
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Al-Thamiree, S. S. M. (2019). Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis. (Doctoral Dissertation). University of Plymouth. Retrieved from http://hdl.handle.net/10026.1/13585
Chicago Manual of Style (16th Edition):
Al-Thamiree, Safaa Salman Mezban. “Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis.” 2019. Doctoral Dissertation, University of Plymouth. Accessed April 11, 2021.
http://hdl.handle.net/10026.1/13585.
MLA Handbook (7th Edition):
Al-Thamiree, Safaa Salman Mezban. “Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis.” 2019. Web. 11 Apr 2021.
Vancouver:
Al-Thamiree SSM. Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis. [Internet] [Doctoral dissertation]. University of Plymouth; 2019. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/10026.1/13585.
Council of Science Editors:
Al-Thamiree SSM. Effect of phytoestrogens on breast and prostate cancer cell lines : potential implications for bone metastasis. [Doctoral Dissertation]. University of Plymouth; 2019. Available from: http://hdl.handle.net/10026.1/13585
28.
LOWRY, MICHELLE.
Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles.
Degree: School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019, Trinity College Dublin
URL: http://hdl.handle.net/2262/86081
► Breast cancer is the most common female cancer diagnosed worldwide. In 2018 alone, there were over 2 million new breast cancer cases diagnosed. In Ireland,…
(more)
▼ Breast cancer is the most common female
cancer diagnosed worldwide. In 2018 alone, there were over 2 million new
breast cancer cases diagnosed. In Ireland,
breast cancer is the most commonly diagnosed
cancer in women. In Ireland,
breast cancer accounts for approximately 3,141 cases each year. Of which, a subtype of
breast cancer called HER2overexpressing/HER2+
breast cancer accounts for 15-25% of
breast cancers. This subtype of
breast cancer has a genetic mutation that causes the
cancer cells to produce larger amounts of the protein called HER2. HER2 promotes the growth of
cancer cells and patients with this type of
breast cancer often have high levels of metastasis, or spread of the
cancer to other organs. Unfortunately, like with many
cancer therapies, some patients do not respond to anti-HER2 therapies, i.e. patients are or become resistant to therapy. Some patient?s tumours will immediately not respond to therapy (innate resistance), whereas, other patient tumour?s will initially respond well to the therapies but overtime the
cancer cells can find ways to overcome the effects of the therapy i.e. the tumours become resistant to therapy (adaptive resistance). Innate and adaptive resistance to anticancer therapies are the main reasons that anti-
cancer drugs fail in the clinic. It is imperative that we investigate the mechanisms of drug resistance, find ways to overcome this resistance and find ways to predict and/or find predictive biomarkers.
The focus of this PhD is on a drug that stops HER2 working, it is called Neratinib. Neratinib prevents HER2 functioning and in doing so it can prevent
cancer cell growth. Neratinib was approved by the Food and Drug Administration (FDA) in July 2017. Neratinib is showing promise in the clinic but, like most therapies, the issue of resistance prevails. We have developed HER2+
breast cancer cell lines that are resistant to neratinib i.e. neratinib does not kill them. When we compared cells that die from neratinib with cells that do not die after neratinib treatment, we found that the resistant cell lines produce very large amounts of a protein called PROTEIN X. The cells that are sensitive to neratinib or the cells that die after neratinib treatment, do not produce large amounts of PROTEIN X. We believe that PROTEIN X acts like a defence system for
breast cancer cells.
This discoveries made in this PhD may be imperative to overcoming neratinib resistance in the future, for predicting response to therapy (so that patients can be stratified into those who are likely versus unlikely to respond to HER-targeting), and so improving the survival rates of patients treated with neratinib and other HER2-targeted therapies. We also believe that PROTEIN X has potential as a predictive biomarker for HER2 therapies such as lapatinib and trastuzumab, but most notably for neratinib. PROTEIN X may be an important marker for future therapeutic decisions in clinics.
Advisors/Committee Members: O'Driscoll, Lorraine.
Subjects/Keywords: Breast cancer; Cancer drug resistance
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
LOWRY, M. (2019). Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/86081
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
LOWRY, MICHELLE. “Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles.” 2019. Thesis, Trinity College Dublin. Accessed April 11, 2021.
http://hdl.handle.net/2262/86081.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
LOWRY, MICHELLE. “Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles.” 2019. Web. 11 Apr 2021.
Vancouver:
LOWRY M. Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles. [Internet] [Thesis]. Trinity College Dublin; 2019. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/2262/86081.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
LOWRY M. Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles. [Thesis]. Trinity College Dublin; 2019. Available from: http://hdl.handle.net/2262/86081
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Namibia
29.
Mowa, AK.
An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek
.
Degree: 2016, University of Namibia
URL: http://hdl.handle.net/11070/1853
► An alarming increase of breast cancer in Namibia started in 2005 with a record of 179 cases, and 1625 cases in 2006 respectively. To date,…
(more)
▼ An alarming increase of breast cancer in Namibia started in 2005 with a record of 179 cases, and 1625 cases in 2006 respectively. To date, the cancer Association of Namibia (CAN) as a registry reported 3092 cancer incidences in 2012. The purpose of this study is to explore the Knowledge, Attitudes and Practices (KAP) and the correlation of the determinant factors on early detection of bread cancer among women in Windhoek. Methods used were the purposive sampling involving 236 women and simple random sampling for selecting six (6) health care facilities in Windhoek, Khomas region. The data collection was conducted over a period of three months, commencing in May 2015 and ended 31st July 2015. A structured questionnaire was used to interview 236 women. The questionnaire consisted of four sections such as Demography, Knowledge, Attitudes and Practice, cross tabulated with variables such as Age, Employment and Educational status. The data were analyzed by using the Statistical Package for Social Science (SPSS) software. The findings indicated that 78.8 % of women had knowledge on breast cancer and early detection, whereas 21.2% lacked the knowledge. The question about sources of information regarding breast cancer yielded the following, clinics recorded 34%, while Television (TV) and radio media with 32.7%. These sources were found to have played the biggest role in information sharing. Women with secondary education (64.5%) were more knowledgeable, followed by those with tertiary levels (29.5%). The age categories of 21-30 and 31- 40 indicated a sum of 46.8% to have knowledge on breast cancer. Attitudes among women on breast cancer practices, multiple responses were given. 92.5% responded that they would consult a Doctor, while 87.6% would be scared about the disease. Fewer responses came from women who wished to consult the traditional healers and prayer house (9.1% and 1.1%) respectively. About 90.5% of women happen to have medical insurance cover whereas 59.0% have no medical insurance cover. About 63% of women have practiced mammogram, while about 31% did not practice the mammogram screening. Employed women and student/ learners (83.3%), reported to be practicing mammogram, while 75.6% of the unemployed didn’t practice mammogram. Age categories of 21-30 and 41-49 recorded 72.1% and 66.7% respectively in practicing mammogram. The use of Clinical Breast Examination recorded a small fraction among respondents as only 27.5% visited the health facilities/ doctor for breast examination, while 72.5% were the women who did not seek any medical or visited the doctor for any clinical breast examination. In conclusion; even though the study findings revealed that the majority of women in Windhoek have a sound knowledge of breast cancer, there are still some negative attitudes towards the screenings and practices as stated in the problem statement that there is an alarming increase of breast cancer in Namibia, therefore the study recommends that, the Ministry of Health and Social Services in collaboration with the Cancer…
Subjects/Keywords: Breast cancer
;
Breast, Cancer, Genetic aspects
;
Breast, Cancer, Social aspects
;
Breast, Cancer, Research
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mowa, A. (2016). An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek
. (Thesis). University of Namibia. Retrieved from http://hdl.handle.net/11070/1853
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mowa, AK. “An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek
.” 2016. Thesis, University of Namibia. Accessed April 11, 2021.
http://hdl.handle.net/11070/1853.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mowa, AK. “An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek
.” 2016. Web. 11 Apr 2021.
Vancouver:
Mowa A. An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek
. [Internet] [Thesis]. University of Namibia; 2016. [cited 2021 Apr 11].
Available from: http://hdl.handle.net/11070/1853.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mowa A. An exploration of knowledge, attitudes and practices and other breast cancer determinants influencing early detection among women in WIndhoek
. [Thesis]. University of Namibia; 2016. Available from: http://hdl.handle.net/11070/1853
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah
30.
Wujcik, Debra M.
Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program.
Degree: PhD, Nursing;, 2007, University of Utah
URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2068/rec/916
► Breast cancer (BC) remains the most common cancer in women. Although screening mammography (SM) is an effective approach for early detection of BC, uninsured, underinsured,…
(more)
▼ Breast cancer (BC) remains the most common cancer in women. Although screening mammography (SM) is an effective approach for early detection of BC, uninsured, underinsured, and minority women often do not have access to SM. The National Breast and Cervical Early Detection Program provide free access to SM. Of women who screen, 10-15% requires further testing, and half of those delay or do not return. Delay may contribute to later stage BC at diagnosis and increased rates of recurrence and death. This study was conducted to identify predictors of delay after an abnormal mammogram and predictors of rescreening behavior in women enrolled in the Tennessee Breast and Cervical Screening Program. Bivariate and multivariate logistic regression analyses were used to explore association between age, race, ethnicity, and marital status, BC history, and presence of breast symptoms and the outcomes of delay and rescreening behavior. Of 11,610 women, 37% required further testing. In a subset of women with time to completion > 1 day, 30% experienced delay > two months. Seventeen percent had another SM during the study period (2002-2006). The high percentage of women needing further testing is likely attributed to the program receiving referrals for diagnosis of symptomatic women as well as asymptomatic screening. Controlling for marital status, age, and BC history, there was more delay in test completion if the women African American versus Caucasian (OR 1.45, 95% CI 1.13, 1.85), Hispanic (OR .72, 95% CI 0.55, 0.93) and reported no breast symptoms (OR 1.50, 95% CI 1.27, 1.77). A delay in receipts of test results > 1 week contributed to the overall delay. Controlling for race and BC history, there was greater likelihood of rescreening if the women were married (OR 1.27, 95% CI 1.12, 1.43) and over 50 years of age (OR 1.92, 95% CI 1.67, 2.21) and less likelihood if the women were non-Hispanic (OR 0.71, 95% CI 0.60, 0.83) and had no breast symptoms (OR 0.85, 95% CI 0.76.,0.96). Findings can be used to identify women at risk for delay, assess understanding of the indication for further test, identify potential barriers to completion of testing or rescreening, and tailor interventions to overcome the barriers.
Subjects/Keywords: Breast Cancer; Health
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APA (6th Edition):
Wujcik, D. M. (2007). Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program. (Doctoral Dissertation). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2068/rec/916
Chicago Manual of Style (16th Edition):
Wujcik, Debra M. “Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program.” 2007. Doctoral Dissertation, University of Utah. Accessed April 11, 2021.
http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2068/rec/916.
MLA Handbook (7th Edition):
Wujcik, Debra M. “Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program.” 2007. Web. 11 Apr 2021.
Vancouver:
Wujcik DM. Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program. [Internet] [Doctoral dissertation]. University of Utah; 2007. [cited 2021 Apr 11].
Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2068/rec/916.
Council of Science Editors:
Wujcik DM. Predictors of delay in resolution after mammography and rescreening behaviors in a state cancer screening program. [Doctoral Dissertation]. University of Utah; 2007. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd2/id/2068/rec/916
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