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Universidade Estadual de Campinas

1. Pereira, Fabricio Ramos Silvestre, 1975-. Conectoma cerebral = aplicações de imageamento por ressonância magnética nuclear em neurociências = Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences: Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences.

Degree: 2013, Universidade Estadual de Campinas

Abstract: Connectome refers to the neural circuitry mapping aiming to identify brain regions that support mental and behavioral functions as well as to detect circuit changes that are linked to psychiatric or neurologic disorders. In practice, connectome studies link several neuroimaging approaches such as MRI, EEG and MEG by means of the estimation of connections among remote brain regions. This "connectivity" among brain regions is usually classified as anatomic, functional or effective. In this work, the technique of connectivity, using MR data, was applied to compare healthy and pathological groups. By means of the anatomical connectivity abnormalities in the white matter of patients with SPG11 mutation were observed. These abnormalities were expressed as the reduction of the levels of fractional anisotropy (FA) and the increase in mean (MD) and radial diffusivities (RD) in sub-cortical regions of temporal and frontal lobe as well as in cingulated gyrus, cuneus, striatum, corpus callosum and brainstem. These findings suggest that neuronal damage/dysfunction is more widespread than previously recognized in this condition. Another anatomical connectivity study showed that such indices of diffusivity were not robust to statistically differentiate between old subjects with and without depression. This lacking on finding differences between both groups indicates that new indices of diffusivity have to emerge in order to provide complementary information about brain subtle microstructures. Functional connectivity was applied to three studies. In the first study, it was observed that patients with unilateral medial temporal lobe epilepsy presented lower levels of functional connectivity during visual or verbal memory tasks. Such reduction was ipsilateral to the side of the lesion and associated to the specific-material used in the memory task. In the second work, the levels of functional connectivity were reduced in hypothalamic regions of obese patients but a partial reversibility of hypothalamic dysfunction was observed after bariatric surgery. In the third, patients with Alzheimer disease presented higher values of functional connectivity in the salience network and a reduction of connectivity values in the default-mode network. Also in these patients, significant correlations between the levels of hyperactivity syndrome and the salience network were observed in the anterior cingulate cortex and right insula areas. These results indicate the potential clinical significance of resting state alterations in future diagnosis and therapy of Alzheimer disease. The effective connectivity approaches demonstrated that old and young subjects have significant differences when encoding words with emotional contents. The influence of the hippocampus on the ipsilateral amygdale was lower for older subjects whereas the influence of the right amygdale on the right hippocampus was increased for these subjects. These findings suggest that brain plasticity also happens as function of age. The same approach was used to estimate the… Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Castellano, Gabriela, 1970- (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Fisiopatologia Médica (nameofprogram), Stella, Florindo (committee member), Rezende, Renato Cabral (committee member), Centroducatte, Paulo Cesar (committee member), Silva, Mauro Antonio Pires Dias da (committee member).

Subjects/Keywords: Neurociências; Espectroscopia de ressonância magnética nuclear; Mapeamento cerebral; Conectividade cerebral; Conectoma; Neurosciences; Magnetic resonance imaging; Brain function mapping; Brain connectivity; Connectome

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APA (6th Edition):

Pereira, Fabricio Ramos Silvestre, 1. (2013). Conectoma cerebral = aplicações de imageamento por ressonância magnética nuclear em neurociências = Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences: Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/312650

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Pereira, Fabricio Ramos Silvestre, 1975-. “Conectoma cerebral = aplicações de imageamento por ressonância magnética nuclear em neurociências = Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences: Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences.” 2013. Thesis, Universidade Estadual de Campinas. Accessed October 23, 2020. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312650.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Pereira, Fabricio Ramos Silvestre, 1975-. “Conectoma cerebral = aplicações de imageamento por ressonância magnética nuclear em neurociências = Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences: Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences.” 2013. Web. 23 Oct 2020.

Vancouver:

Pereira, Fabricio Ramos Silvestre 1. Conectoma cerebral = aplicações de imageamento por ressonância magnética nuclear em neurociências = Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences: Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences. [Internet] [Thesis]. Universidade Estadual de Campinas; 2013. [cited 2020 Oct 23]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312650.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pereira, Fabricio Ramos Silvestre 1. Conectoma cerebral = aplicações de imageamento por ressonância magnética nuclear em neurociências = Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences: Brain connectome : aplications of nuclear magnetic resonance imaging in neurosciences. [Thesis]. Universidade Estadual de Campinas; 2013. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312650

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. ΔΙΑΜΑΝΤΟΠΟΥΛΟΣ, ΠΑΝΤΕΛΗΣ. ΕΝΔΟΜΗΤΡΙΑ ΧΑΡΤΟΓΡΑΦΗΣΗ ΜΕ ΤΟ ΒΙΟΜΑΓΝΗΤΟΜΕΤΡΟ SQUID ΤΟΥ ΕΓΚΕΦΑΛΟΥ ΕΜΒΡΥΩΝ (28-36 ΕΒΔΟΜΑΔΩΝ) ΣΕ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΚΥΗΣΕΙΣ.

Degree: 1994, Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ); Democritus University of Thrace (DUTH)

ΜΕΤΑΞΥ ΤΩΝ ΕΤΩΝ 1987 ΕΩΣ 1992 ΜΕΤΡΗΘΗΚΕ, ΜΕ ΤΟ ΒΙΟΜΑΓΝΗΤΟΜΕΤΡΟ SQUID, Η ΕΚΠΕΜΠΟΜΕΝΗ ΜΑΓΝΗΤΙΚΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ ΑΠΟ ΤΟΝ ΕΓΚΕΦΑΛΟ 24 ΕΜΒΡΥΩΝ, ΕΝΔΟΜΗΤΡΙΑ, ΣΕ 12 ΠΑΘΟΛΟΓΙΚΕΣ ΚΑΙ 12 ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΥΗΣΕΙΣ ΜΑΡΤΥΡΕΣ, ΜΕ ΗΛΙΚΙΑ ΚΥΗΣΗΣ 28-36 EΒΔΟΜΑΔΩΝ. ΕΓΙΝΕ ΕΠΕΞΕΡΓΑΣΙΑ ΤΩΝ ΔΕΔΟΜΕΝΩΝ ΣΕ ΗΛΕΚΤΡΟΝΙΚΟ ΥΠΟΛΟΓΙΣΤΗ KAI ΜΕΛΕΤΗΘΗΚΑΝ ΟΙ ΚΥΜΑΤΟΜΟΡΦΕΣ, Η ΦΑΣΜΑΤΙΚΗ ΑΝΑΛΥΣΗ ΚΑΙ ΟΙ ΧΑΡΤΕΣ ΙΣΟΥΨΩΝ ΚΑΜΠΥΛΩΝ ΠΟΥ ΠΡΟΕΚΥΨΑΝ. ΠΑΡΑΛΛΗΛΑ, ΣΥΣΧΕΤΙΣΘΗΚΑΝ ΤΑ ΣΧΗΜΑΤΑ ΑΥΤΑ ΜΕ ΤΑ ΑΝΤΙΣΤΟΙΧΑ ΚΑΤΑΞΙΩΜΕΝΩΝ ΜΕΘΟΔΩΝ ΕΜΜΕΣΗΣ ΕΚΤΙΜΗΣΗΣ ΤΗΣ ΕΓΚΕΦΑΛΙΚΗΣ ΛΕΙΤΟΥΡΓΙΑΣ ΤΟΥ ΕΜΒΡΥΟΥ (N.S.T., ΒΙΟΦΥΣΙΚΟ ΠΡΟΦΙΛ, ΑΙΜΑΤΟΛΟΓΙΚΟ-ΒΙΟΧΗΜΙΚΟ ΕΛΕΓΧΟ). ΥΠΗΡΞΕ ΜΙΑ ΘΕΤΙΚΗ ΣΥΣΧΕΤΙΣΗ ΜΕΤΑΞΥ ΤΩΝ ΕΥΡΗΜΑΤΩΝ ΣΤΗ ΔΕΣΜΗ ΣΥΧΝΟΤΗΤΩΝ 2-7 HZ ΚΑΙ ΤΩΝ ΠΑΘΟΛΟΓΙΚΩΝ ΚΥΗΣΕΩΝ. ΠΑΡΟΛΟ ΤΟΝ ΣΧΕΤΙΚΑ ΜΙΚΡΟ ΑΡΙΘΜΟ ΤΩΝ ΚΥΗΣΕΩΝ ΠΟΥ ΜΕΛΕΤΗΘΗΚΑΝ, ΠΙΣΤΕΥΟΥΜΕ ΟΤΙ ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΠΟΥ ΠΡΟΕΚΥΨΑΝ ΕΙΝΑΙ ΕΝΘΑΡΡΥΝΤΙΚΑ ΚΑΙ ΟΤΙ Η ΜΗ ΕΠΕΜΒΑΤΙΚΗ ΑΥΤΗ ΤΕΧΝΙΚΗ ΜΠΟΡΕΙ ΝΑ ΔΩΣΕΙ ΧΡΗΣΙΜΕΣ ΠΛΗΡΟΦΟΡΙΕΣ ΓΙΑ ΤΗΝ ΕΓΚΕΦΑΛΙΚΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ ΧΩΡΙΣ ΝΑ ΕΠΗΡΕΑΣΕΙ ΤΗΝ ΕΓΚΕΦΑΛΙΚΗ ΛΕΙΤΟΥΡΓΙΑ.

FROM 1987 TILL THE END OF 1992 WE EXAMINED USING THE BIOMAGNETOMETER SQUID, THEEMMITED BIOMAGNETIC ACTIVITY FROM THE FETUS BRAIN OF 24 PREGNANT WOMEN, INTRAUTERINE, WITH GESTATIONAL AGE 28-36 WEEKS. WE PERFORMED THE BRAIN MAPPING TECHNIQUE ON THESE FETUSES AND WE COMPARED OUR RESULTS TO KNOWN CONTROL PARAMETERS, SUCH AS N.S.T. AND BIOPHYSICAL PROFILE. THERE WAS A POSITIVE CORRELATION BETWEEN THE WAVEFORMS, SPECTRA AND ISO-SA MAPS IN THE FREQUENCY RANGE OF 2-7 HZ AND THE PATHOLOGICAL PREGNANCIES. DΕSPITE THE RELATIVELY SMALL NUMBER OF PREGNANCIES THAT WE STUDIED IN OUR RESEARCH, WE FOUND THAT THE NON-INVASIVE SQUID METHOD CAN GIVE VALUABLE INFORMATION ON BRAIN ACTIVITY WITH RESPECT TO THEFETAL BRAIN FUNCTION.

Subjects/Keywords: FETAL BRAIN FUNCTION; FETUS AGED 28-36 WEEKS; INTRAUTERINE MAPPING; Magnetoencephalography; PROECLAMPSIA; Squid; ΕΜΒΡΥΙΚΗ ΕΓΚΕΦΑΛΙΚΗ ΛΕΙΤΟΥΡΓΙΑ; ΕΜΒΡΥΟ 28-36 ΕΒΔΟΜΑΔΩΝ; ΕΝΔΟΜΗΤΡΙΑ ΧΑΡΤΟΓΡΑΦΗΣΗ; Μαγνητοεγκεφαλογραφία; Προεκλαμψία

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APA (6th Edition):

ΔΙΑΜΑΝΤΟΠΟΥΛΟΣ, . (1994). ΕΝΔΟΜΗΤΡΙΑ ΧΑΡΤΟΓΡΑΦΗΣΗ ΜΕ ΤΟ ΒΙΟΜΑΓΝΗΤΟΜΕΤΡΟ SQUID ΤΟΥ ΕΓΚΕΦΑΛΟΥ ΕΜΒΡΥΩΝ (28-36 ΕΒΔΟΜΑΔΩΝ) ΣΕ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΚΥΗΣΕΙΣ. (Thesis). Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ); Democritus University of Thrace (DUTH). Retrieved from http://hdl.handle.net/10442/hedi/3453

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

ΔΙΑΜΑΝΤΟΠΟΥΛΟΣ, ΠΑΝΤΕΛΗΣ. “ΕΝΔΟΜΗΤΡΙΑ ΧΑΡΤΟΓΡΑΦΗΣΗ ΜΕ ΤΟ ΒΙΟΜΑΓΝΗΤΟΜΕΤΡΟ SQUID ΤΟΥ ΕΓΚΕΦΑΛΟΥ ΕΜΒΡΥΩΝ (28-36 ΕΒΔΟΜΑΔΩΝ) ΣΕ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΚΥΗΣΕΙΣ.” 1994. Thesis, Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ); Democritus University of Thrace (DUTH). Accessed October 23, 2020. http://hdl.handle.net/10442/hedi/3453.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

ΔΙΑΜΑΝΤΟΠΟΥΛΟΣ, ΠΑΝΤΕΛΗΣ. “ΕΝΔΟΜΗΤΡΙΑ ΧΑΡΤΟΓΡΑΦΗΣΗ ΜΕ ΤΟ ΒΙΟΜΑΓΝΗΤΟΜΕΤΡΟ SQUID ΤΟΥ ΕΓΚΕΦΑΛΟΥ ΕΜΒΡΥΩΝ (28-36 ΕΒΔΟΜΑΔΩΝ) ΣΕ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΚΥΗΣΕΙΣ.” 1994. Web. 23 Oct 2020.

Vancouver:

ΔΙΑΜΑΝΤΟΠΟΥΛΟΣ . ΕΝΔΟΜΗΤΡΙΑ ΧΑΡΤΟΓΡΑΦΗΣΗ ΜΕ ΤΟ ΒΙΟΜΑΓΝΗΤΟΜΕΤΡΟ SQUID ΤΟΥ ΕΓΚΕΦΑΛΟΥ ΕΜΒΡΥΩΝ (28-36 ΕΒΔΟΜΑΔΩΝ) ΣΕ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΚΥΗΣΕΙΣ. [Internet] [Thesis]. Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ); Democritus University of Thrace (DUTH); 1994. [cited 2020 Oct 23]. Available from: http://hdl.handle.net/10442/hedi/3453.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

ΔΙΑΜΑΝΤΟΠΟΥΛΟΣ . ΕΝΔΟΜΗΤΡΙΑ ΧΑΡΤΟΓΡΑΦΗΣΗ ΜΕ ΤΟ ΒΙΟΜΑΓΝΗΤΟΜΕΤΡΟ SQUID ΤΟΥ ΕΓΚΕΦΑΛΟΥ ΕΜΒΡΥΩΝ (28-36 ΕΒΔΟΜΑΔΩΝ) ΣΕ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΚΥΗΣΕΙΣ. [Thesis]. Δημοκρίτειο Πανεπιστήμιο Θράκης (ΔΠΘ); Democritus University of Thrace (DUTH); 1994. Available from: http://hdl.handle.net/10442/hedi/3453

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Metwalli, Nader. High angular resolution diffusion-weighted magnetic resonance imaging: adaptive smoothing and applications.

Degree: PhD, Biomedical Engineering, 2010, Georgia Tech

Diffusion-weighted magnetic resonance imaging (MRI) has allowed unprecedented non-invasive mapping of brain neural connectivity in vivo by means of fiber tractography applications. Fiber tractography has emerged as a useful tool for mapping brain white matter connectivity prior to surgery or in an intraoperative setting. The advent of high angular resolution diffusion-weighted imaging (HARDI) techniques in MRI for fiber tractography has allowed mapping of fiber tracts in areas of complex white matter fiber crossings. Raw HARDI images, as a result of elevated diffusion-weighting, suffer from depressed signal-to-noise ratio (SNR) levels. The accuracy of fiber tractography is dependent on the performance of the various methods extracting dominant fiber orientations from the HARDI-measured noisy diffusivity profiles. These methods will be sensitive to and directly affected by the noise. In the first part of the thesis this issue is addressed by applying an objective and adaptive smoothing to the noisy HARDI data via generalized cross-validation (GCV) by means of the smoothing splines on the sphere method for estimating the smooth diffusivity profiles in three dimensional diffusion space. Subsequently, fiber orientation distribution functions (ODFs) that reveal dominant fiber orientations in fiber crossings are then reconstructed from the smoothed diffusivity profiles using the Funk-Radon transform. Previous ODF smoothing techniques have been subjective and non-adaptive to data SNR. The GCV-smoothed ODFs from our method are accurate and are smoothed without external intervention facilitating more precise fiber tractography. Diffusion-weighted MRI studies in amyotrophic lateral sclerosis (ALS) have revealed significant changes in diffusion parameters in ALS patient brains. With the need for early detection of possibly discrete upper motor neuron (UMN) degeneration signs in patients with early ALS, a HARDI study is applied in order to investigate diffusion-sensitive changes reflected in the diffusion tensor imaging (DTI) measures axial and radial diffusivity as well as the more commonly used measures fractional anisotropy (FA) and mean diffusivity (MD). The hypothesis is that there would be added utility in considering axial and radial diffusivities which directly reflect changes in the diffusion tensors in addition to FA and MD to aid in revealing neurodegenerative changes in ALS. In addition, applying adaptive smoothing via GCV to the HARDI data further facilitates the application of fiber tractography by automatically eliminating spurious noisy peaks in reconstructed ODFs that would mislead fiber tracking. Advisors/Committee Members: Hu, Xiaoping (Committee Chair), Carew, John (Committee Co-Chair), Benatar, Michael (Committee Member), Martin, Diego (Committee Member), Oshinski, John (Committee Member).

Subjects/Keywords: Orientation distribution function (ODF); Q-ball imaging (QBI); Smoothing splines on the sphere; Generalized cross-validation (GCV); Funk-Radon transform (FRT); Radial diffusivity; Axial diffusivity; Amyotrophic lateral sclerosis (ALS); Diffusion tensor imaging (DTI); High angular resolution diffusion-weighted imaging; Magnetic resonance imaging; MRI; Brain mapping; Diagnostic imaging; Diffusion magnetic resonance imaging

…Orientation Distribution Function (ODF) Reconstruction 41 2.3.3 In Vivo Human Brain Data… …mapping of brain neural connectivity in vivo by means of fiber tractography applications. Fiber… …tractography has emerged as a useful tool for mapping brain white matter connectivity prior to… …Introduction Fiber tractography has emerged as a useful tool for mapping brain white matter prior to… …function R(θ) . The different diffusion profiles found in the brain are merely a… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Metwalli, N. (2010). High angular resolution diffusion-weighted magnetic resonance imaging: adaptive smoothing and applications. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/34854

Chicago Manual of Style (16th Edition):

Metwalli, Nader. “High angular resolution diffusion-weighted magnetic resonance imaging: adaptive smoothing and applications.” 2010. Doctoral Dissertation, Georgia Tech. Accessed October 23, 2020. http://hdl.handle.net/1853/34854.

MLA Handbook (7th Edition):

Metwalli, Nader. “High angular resolution diffusion-weighted magnetic resonance imaging: adaptive smoothing and applications.” 2010. Web. 23 Oct 2020.

Vancouver:

Metwalli N. High angular resolution diffusion-weighted magnetic resonance imaging: adaptive smoothing and applications. [Internet] [Doctoral dissertation]. Georgia Tech; 2010. [cited 2020 Oct 23]. Available from: http://hdl.handle.net/1853/34854.

Council of Science Editors:

Metwalli N. High angular resolution diffusion-weighted magnetic resonance imaging: adaptive smoothing and applications. [Doctoral Dissertation]. Georgia Tech; 2010. Available from: http://hdl.handle.net/1853/34854

.