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You searched for subject:(Biphasic separation). Showing records 1 – 3 of 3 total matches.

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Georgia Tech

1. Hill, Elizabeth M. Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts.

Degree: PhD, Chemical Engineering, 2007, Georgia Tech

Sustainable technologies are vital to reducing the environmental impact of chemical enterprises. Solvents are often seen as just a medium in which a reaction takes place; however they can also play a dominant role in the overall toxicity of a typical pharmaceutical/fine chemicals batch chemical operation. Further, careful solvent selection for a reaction may also lead to more facile separation and purification of products, thus reducing the overall cost of a chemical process. This thesis presents an environmentally benign processing technique for sustainable biocatalytic reactions coupled with facile built-in separation. An organic aqueous tunable solvent (OATS) system allows access to a hydrophobic substrate which is transformed with a homogeneous enzymatic catalyst in a single liquid phase. Subsequent CO2 addition produces a biphasic mixture where the hydrophobic product partitions preferentially into the organic rich phase for separation while the hydrophilic enzyme catalyst partitions into the aqueous rich phase, where it is recyclable. Processing parameters in OATS systems are discussed and an overall product recovery of 80% is observed after six reaction cycles. Additionally, greater than 99% enantiomeric excess (ee) is shown for catalyzed hydrolysis of rac-1-phenylethyl acetate with Candida antarctica lipase B (CAL B) both before and after CO2-induced separation. Advisors/Committee Members: Dr. Charles A. Eckert (Committee Co-Chair), Dr. Charles L. Liotta (Committee Co-Chair), Dr. Andreas Bommarius (Committee Member), Dr. Carson Meredith (Committee Member), Dr. Hang Lu (Committee Member).

Subjects/Keywords: Gas-expanded liquids; Biphasic separation; Biocatalysis

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APA (6th Edition):

Hill, E. M. (2007). Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/16320

Chicago Manual of Style (16th Edition):

Hill, Elizabeth M. “Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts.” 2007. Doctoral Dissertation, Georgia Tech. Accessed November 27, 2020. http://hdl.handle.net/1853/16320.

MLA Handbook (7th Edition):

Hill, Elizabeth M. “Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts.” 2007. Web. 27 Nov 2020.

Vancouver:

Hill EM. Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts. [Internet] [Doctoral dissertation]. Georgia Tech; 2007. [cited 2020 Nov 27]. Available from: http://hdl.handle.net/1853/16320.

Council of Science Editors:

Hill EM. Benign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalysts. [Doctoral Dissertation]. Georgia Tech; 2007. Available from: http://hdl.handle.net/1853/16320

2. Broeke, J. (Joep) van den. Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media.

Degree: 2003, University Utrecht

The recycling of homogeneous catalysts is highly desirable from both an environmental and an economical point of view. However, the fact that catalysts and products are distributed homogeneously throughout the reaction mixture hampers catalyst separation. An elegant approach facilitating catalyst recovery is its immobilisation in a liquid support. Three solvent systems that have shown promise in this respect are fluorous biphasic solvent systems, supercritical carbon dioxide and ionic liquids. This thesis addresses the development of highly fluorous tetraarylborate anions which can be employed as such, or in combination with fluorous ligands, to enhance the solubility and performance of ionic catalysts in perfluorinated solvents and supercritical carbon dioxide. Furthermore, these anions have been used in the design of ionic liquids with unprecedented physical properties.

Subjects/Keywords: homogeneous catalysis; tetraarylborate anions; fluorous biphasic catalyst separation; supercritical carbon dioxide; ionic liquids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Broeke, J. (. v. d. (2003). Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/771 ; URN:NBN:NL:UI:10-1874-771 ; URN:NBN:NL:UI:10-1874-771 ; https://dspace.library.uu.nl/handle/1874/771

Chicago Manual of Style (16th Edition):

Broeke, J (Joep) van den. “Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media.” 2003. Doctoral Dissertation, University Utrecht. Accessed November 27, 2020. https://dspace.library.uu.nl/handle/1874/771 ; URN:NBN:NL:UI:10-1874-771 ; URN:NBN:NL:UI:10-1874-771 ; https://dspace.library.uu.nl/handle/1874/771.

MLA Handbook (7th Edition):

Broeke, J (Joep) van den. “Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media.” 2003. Web. 27 Nov 2020.

Vancouver:

Broeke J(vd. Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media. [Internet] [Doctoral dissertation]. University Utrecht; 2003. [cited 2020 Nov 27]. Available from: https://dspace.library.uu.nl/handle/1874/771 ; URN:NBN:NL:UI:10-1874-771 ; URN:NBN:NL:UI:10-1874-771 ; https://dspace.library.uu.nl/handle/1874/771.

Council of Science Editors:

Broeke J(vd. Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media. [Doctoral Dissertation]. University Utrecht; 2003. Available from: https://dspace.library.uu.nl/handle/1874/771 ; URN:NBN:NL:UI:10-1874-771 ; URN:NBN:NL:UI:10-1874-771 ; https://dspace.library.uu.nl/handle/1874/771


Universiteit Utrecht

3. Broeke, J. (Joep) van den. Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media.

Degree: 2003, Universiteit Utrecht

The recycling of homogeneous catalysts is highly desirable from both an environmental and an economical point of view. However, the fact that catalysts and products are distributed homogeneously throughout the reaction mixture hampers catalyst separation. An elegant approach facilitating catalyst recovery is its immobilisation in a liquid support. Three solvent systems that have shown promise in this respect are fluorous biphasic solvent systems, supercritical carbon dioxide and ionic liquids. This thesis addresses the development of highly fluorous tetraarylborate anions which can be employed as such, or in combination with fluorous ligands, to enhance the solubility and performance of ionic catalysts in perfluorinated solvents and supercritical carbon dioxide. Furthermore, these anions have been used in the design of ionic liquids with unprecedented physical properties.

Subjects/Keywords: Scheikunde; homogeneous catalysis; tetraarylborate anions; fluorous biphasic catalyst separation; supercritical carbon dioxide; ionic liquids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Broeke, J. (. v. d. (2003). Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/771

Chicago Manual of Style (16th Edition):

Broeke, J (Joep) van den. “Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media.” 2003. Doctoral Dissertation, Universiteit Utrecht. Accessed November 27, 2020. http://dspace.library.uu.nl:8080/handle/1874/771.

MLA Handbook (7th Edition):

Broeke, J (Joep) van den. “Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media.” 2003. Web. 27 Nov 2020.

Vancouver:

Broeke J(vd. Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2003. [cited 2020 Nov 27]. Available from: http://dspace.library.uu.nl:8080/handle/1874/771.

Council of Science Editors:

Broeke J(vd. Highly Fluorous Tetraarylborate Anions : Versatile Counterions for Homogeneous Catalysis in Novel Reaction Media. [Doctoral Dissertation]. Universiteit Utrecht; 2003. Available from: http://dspace.library.uu.nl:8080/handle/1874/771

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