subject:(Biomedical materials Imaging compatibility)

University of Washington

1. Sotiri, Irini. Study of Protein-Fluoropolymer Interactions for Passivation of Blood-Contacting Surfaces.

Degree: 2018, University of Washington

► While decades of biomaterials research have yielded devices that prolong the lives of cardiovascular disease patients, clinicians still rely on dangerous anticoagulants to ensure their… (more)

Subjects/Keywords: biocompatibility; biomaterials; blood compatibility; fluoropolymer; medical device; proteins; Biomedical engineering; Materials Science; Bioengineering

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APA (6^th Edition):

Sotiri, I. (2018). Study of Protein-Fluoropolymer Interactions for Passivation of Blood-Contacting Surfaces. (Thesis). University of Washington. Retrieved from http://hdl.handle.net/1773/42963

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sotiri, Irini. “Study of Protein-Fluoropolymer Interactions for Passivation of Blood-Contacting Surfaces.” 2018. Thesis, University of Washington. Accessed January 24, 2021. http://hdl.handle.net/1773/42963.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sotiri, Irini. “Study of Protein-Fluoropolymer Interactions for Passivation of Blood-Contacting Surfaces.” 2018. Web. 24 Jan 2021.

Vancouver:

Sotiri I. Study of Protein-Fluoropolymer Interactions for Passivation of Blood-Contacting Surfaces. [Internet] [Thesis]. University of Washington; 2018. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1773/42963.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sotiri I. Study of Protein-Fluoropolymer Interactions for Passivation of Blood-Contacting Surfaces. [Thesis]. University of Washington; 2018. Available from: http://hdl.handle.net/1773/42963

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario

2. Li, Ying. Electrospun collagen fibers for tissue regeneration applications.

Degree: 2018, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/5721

► Tissue engineering aims to regenerate damaged and deceased tissue by combining cells with scaffold made from an appropriate biomaterial and providing a conducive environment to… (more)

▼ Tissue engineering aims to regenerate damaged and deceased tissue by combining cells with scaffold made from an appropriate biomaterial and providing a conducive environment to guide cell growth and the formation or regeneration of new tissue or organ. While collagen, an important material of the extracellular matrix (ECM), is a natural choice as a scaffold biomaterial, the conducive environment can only be created by having the ability to control the geometry, organization, structural and mechanical properties of the scaffold. Moreover, degradability and degradation rate control of the scaffold has to be taken into consideration too. In this work, we aim at developing a scaffold that possess the geometry, organization, structural and mechanical properties of the ECM, that is also degradable with degradation rate control. We accomplish this through fabrication of scaffolds composed of collagen fibers with diameters of ~ 50 to 500 nm using electrospinning. These fibers can be organized and provide structural and mechanical support for the cells populating it. The versatile electrospinning setup not only allows mimicking the define architecture of the native ECM environment containing collagen fibers but, in the core-shell or porous structure, can also enable bioactive molecule encapsulation and their controlled release into the cell culture environment. Post fabrication processing for fiber stability via chemical or photochemical crosslinking as well as ion implantation resulted in fibers with controlled degradation rate and enhanced mechanical properties. Chemical structure characterization demonstrated close resemblance of fiber surface and native collagen. Favorable cell adhesion and proliferation demonstrated good cell compatibility using the human fetal lung (IMR-90) cells. By implementing the strategy developed in this thesis to construct scaffolds using electrospun collagen fiber that possess appropriate organization and properties to mimic the natural environment, scaffolds can be custom designed for specific tissue engineering applications with potentially improved outcome.

Subjects/Keywords: Electrospinning; collagen; crosslinking; nanomechanics; cell compatibility; nanofiber; fiber organization; Biology and Biomimetic Materials; Biomaterials; Biomedical Devices and Instrumentation; Mechanics of Materials

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APA (6^th Edition):

Li, Y. (2018). Electrospun collagen fibers for tissue regeneration applications. (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/5721

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Ying. “Electrospun collagen fibers for tissue regeneration applications.” 2018. Thesis, University of Western Ontario. Accessed January 24, 2021. https://ir.lib.uwo.ca/etd/5721.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Ying. “Electrospun collagen fibers for tissue regeneration applications.” 2018. Web. 24 Jan 2021.

Vancouver:

Li Y. Electrospun collagen fibers for tissue regeneration applications. [Internet] [Thesis]. University of Western Ontario; 2018. [cited 2021 Jan 24]. Available from: https://ir.lib.uwo.ca/etd/5721.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li Y. Electrospun collagen fibers for tissue regeneration applications. [Thesis]. University of Western Ontario; 2018. Available from: https://ir.lib.uwo.ca/etd/5721

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Choi, Sungmoon. Fluorescent noble metal nanodots for biological applications.

Degree: PhD, Chemistry and Biochemistry, 2010, Georgia Tech

URL: http://hdl.handle.net/1853/37195

► Commercial organic dyes are widely used for cellular staining due to their small size, high brightness, and chemical functionality. However, their blinking and photobleaching are… (more)

Subjects/Keywords: DNA; Nanodots; Drug delivery; Cellular staining; Fluorophores; Silver; Drug delivery systems; Biomedical materials Imaging compatibility; Diagnostic imaging

…Dioleoyl-3-Trimethylammonium Propane Magnetic resonance imaging Bovine serum albumin x SUMMARY… …might be outstanding imaging agents for in vivo studies when encapsulated in delivery vehicles… …optical imaging in high background environments. These good xi characteristics are combined… …imaging and novel photostability. It could be a powerful cellular marker for biological… …application when time-gated imaging techniques are applied. xii CHAPTER I Introduction 1-1…

10 more images…

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APA (6^th Edition):

Choi, S. (2010). Fluorescent noble metal nanodots for biological applications. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/37195

Chicago Manual of Style (16^th Edition):

Choi, Sungmoon. “Fluorescent noble metal nanodots for biological applications.” 2010. Doctoral Dissertation, Georgia Tech. Accessed January 24, 2021. http://hdl.handle.net/1853/37195.

MLA Handbook (7^th Edition):

Choi, Sungmoon. “Fluorescent noble metal nanodots for biological applications.” 2010. Web. 24 Jan 2021.

Vancouver:

Choi S. Fluorescent noble metal nanodots for biological applications. [Internet] [Doctoral dissertation]. Georgia Tech; 2010. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1853/37195.

Council of Science Editors:

Choi S. Fluorescent noble metal nanodots for biological applications. [Doctoral Dissertation]. Georgia Tech; 2010. Available from: http://hdl.handle.net/1853/37195

University of Washington

4. Arami, Hamed. Magnetic Particle Imaging (MPI) Tracers for In Vivo Applications.

Degree: PhD, 2016, University of Washington

URL: http://hdl.handle.net/1773/35245

► Magnetic particle imaging (MPI) is a real-time, quantitative and clinically safe imaging technique, potentially applicable for future clinical applications such as cancer imaging, cardiovascular imaging… (more)

▼ Magnetic particle imaging (MPI) is a real-time, quantitative and clinically safe imaging technique, potentially applicable for future clinical applications such as cancer imaging, cardiovascular imaging or stem cell labeling and tracking. MPI performance (i.e. spatial resolution and sensitivity) is highly dependent on nanoparticles (NPs) size distribution, magnetization and environment. Therefore, NPs MPI signal is different after distribution into tissues or binding to the cells. In this project, we evaluated the potential capabilities of MPI for tissue targeted imaging applications such as cancer imaging. To do this, we used two preliminary experimental models to predict the performance of the tracers in a tissue equivalent environment and an acidic lysosome-like solution. For efficient targeting and specific binding of the NPs to specific cells (e.g. cancers), it is required to conjugate additional biomolecules that can be recognized by receptors on the membranes of these cells. Therefore, we introduced functional groups (such as amine, carboxyl and maleimide groups) to the surface of our optimized MPI tracers and used them for bonding of a brain cancer targeting peptide (lactoferrin) to the NPs and evaluated the targeting efficacy of these MPI tracers using an in vivo glioma xenograft model. We also conjugated Cy5.5 near infra-red fluorescent (NIRF) molecules to these functional groups and evaluated NPs performance as multimodal MPI tracers. This additional modality enabled us to study the biodistribution and pharmacokinetics of our optimized MPI tracers more accurately, since NIRF revealed more details of microstructural distribution of the NPs in different organs. In addition, we investigated the pharmacokinetics and biodistribution of the intravenously injected NPs and evaluated MPI performance of the NPs after their accumulation in reticuloendothelial system (RES) organs (e.g. liver and spleen), and glioma xenografts. Advisors/Committee Members: Krishnan, Kannan (advisor).

Subjects/Keywords: biomedical; Imaging; in vivo; Magnetic; nanoparticle; Biomedical engineering; Materials Science; Nanoscience; materials science and engineering

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APA (6^th Edition):

Arami, H. (2016). Magnetic Particle Imaging (MPI) Tracers for In Vivo Applications. (Doctoral Dissertation). University of Washington. Retrieved from http://hdl.handle.net/1773/35245

Chicago Manual of Style (16^th Edition):

Arami, Hamed. “Magnetic Particle Imaging (MPI) Tracers for In Vivo Applications.” 2016. Doctoral Dissertation, University of Washington. Accessed January 24, 2021. http://hdl.handle.net/1773/35245.

MLA Handbook (7^th Edition):

Arami, Hamed. “Magnetic Particle Imaging (MPI) Tracers for In Vivo Applications.” 2016. Web. 24 Jan 2021.

Vancouver:

Arami H. Magnetic Particle Imaging (MPI) Tracers for In Vivo Applications. [Internet] [Doctoral dissertation]. University of Washington; 2016. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1773/35245.

Council of Science Editors:

Arami H. Magnetic Particle Imaging (MPI) Tracers for In Vivo Applications. [Doctoral Dissertation]. University of Washington; 2016. Available from: http://hdl.handle.net/1773/35245

McMaster University

5. Iranpanah, Behzad. Tissue Stabilization in MRI-Guided Breast Biopsy.

Degree: MASc, 2013, McMaster University

URL: http://hdl.handle.net/11375/15273

►

Breast cancer is the most common form of cancer in women in the United States. Histopathological examination through breast biopsy is considered as the… (more)

▼

Breast cancer is the most common form of cancer in women in the United States. Histopathological examination through breast biopsy is considered as the "Gold Standard" for a definitive diagnosis. Contrast-enhanced Magnetic Resonance Imaging (MRI) is often used for guiding the biopsy in those cases in which the tumor may not be detectable under Ultrasound or X-ray mammography. Stabilization of the breast tissue during the biopsy is critical for its success to ensure that the target would not be displaced due to the patient movement or tissue deformation. Conventionally, the breast tissue is immobilized by firmly compressing it between two parallel plates. However, high compression forces causes significant patient discomfort and can reduce the intake of the contrast agent, which negatively impact the image quality. This thesis introduces devices and control methodologies for active tissue stabilization in magnetic resonance imaging (MRI)-guided breast biopsy. Pneumatic and piezoelectric actuators have been considered for developing concept designs for MRI-compatible tissue stabilization devices. Only the pneumatic device has been prototyped and tested. The device is comprised of two pneumatically-actuated support plates that would stabilize the biopsy target movements during needle insertion. An optimized geometry for the support plates allows for a good degree of tissue stabilization without relying on large compression forces. The plate configuration can also be adjusted inside the magnet bore using pneumatic actuators driven by pressure-controlled valves that are placed in the MR control room. This capability allows for the compensation of the target displacement based on MR image feedback. When combined with a separate needle drive mechanism, this stabilization device would enable in-bore MR-guided breast biopsy in combination with an in-bore needle driver system. The proposed approach offers improved target stabilization at reduced compression force and patient discomfort, that may also enhance MR image quality as result of greater intake of contrast agent. The open-front design of the stabilization plates provides greater flexibility in selecting the needle insertion entry point, and active adjustment of the support plates based on MR feedback improves the targeting accuracy. A concept design for a MR-compatible needle driver mechanism using piezoelectric actuators is also proposed. Experiments performed on chicken breast tissue with a prototype of the device demonstrate the effectiveness of this mechanism in increasing needle targeting accuracy using two simple error correction strategies. Furthermore, MRI compatibility tests are carried out to asses the performance of the device inside MRI.

Master of Applied Science (MASc)

Advisors/Committee Members: Sirouspour, Shahin, Patriciu, Alexandru, Jeremic, Aleksandar, Biomedical Engineering.

Subjects/Keywords: Breast biopsy; Magnetic Resonance Imaging; Tissue stabilization; MR-compatibility; MR-guided breast biopsy; Compression plates; Biomedical Engineering and Bioengineering; Biomedical Engineering and Bioengineering

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APA (6^th Edition):

Iranpanah, B. (2013). Tissue Stabilization in MRI-Guided Breast Biopsy. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/15273

Chicago Manual of Style (16^th Edition):

Iranpanah, Behzad. “Tissue Stabilization in MRI-Guided Breast Biopsy.” 2013. Masters Thesis, McMaster University. Accessed January 24, 2021. http://hdl.handle.net/11375/15273.

MLA Handbook (7^th Edition):

Iranpanah, Behzad. “Tissue Stabilization in MRI-Guided Breast Biopsy.” 2013. Web. 24 Jan 2021.

Vancouver:

Iranpanah B. Tissue Stabilization in MRI-Guided Breast Biopsy. [Internet] [Masters thesis]. McMaster University; 2013. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/11375/15273.

Council of Science Editors:

Iranpanah B. Tissue Stabilization in MRI-Guided Breast Biopsy. [Masters Thesis]. McMaster University; 2013. Available from: http://hdl.handle.net/11375/15273

University of Melbourne

6. Ng, Amanda Ching Lih. Techniques for the processing and analysis of magnetic resonance imaging phase data.

Degree: 2013, University of Melbourne

URL: http://hdl.handle.net/11343/38674

► From its beginnings in the 1970s, the medical imaging field of magnetic resonance (MR) imaging has focussed primarily on the magnitude of the acquired complex… (more)

▼ From its beginnings in the 1970s, the medical imaging field of magnetic resonance (MR) imaging has focussed primarily on the magnitude of the acquired complex data. With ever increasing magnet field strengths, interest in the phase, or argument, of complex T2*-weighted gradient echo MR data has grown. Compared to magnitude images, phase images provide novel contrast and increased sensitivity to tissue properties such as magnetic susceptibility. Several post-acquisition processing methods exploit this sensitivity to susceptibility, notably Susceptibility-Weighted Imaging (SWI) and Quantitative Susceptibility Mapping (QSM). These methods provide greater contrast valuable in the visualisation of biological structures, such as venous vessels, tumours, haemorrhages and subcortical structures. QSM, in particular, may provide the ability to infer changes in chemical composition, such as iron deposition, which is important in the progression of several neurodegenerative disorders such as Parkinson's Disease and Alzheimer's Disease. Phase imaging-based methods such as SWI and QSM operate on processed phase data. The argument of a complex number is inherently circular, and the MR phase is often affected by spatially slow varying inhomogeneities. In order to extract the localised phase contrast required for SWI and QSM, a combination of phase unwrapping and high pass filtering is necessary. This task is non-trivial, with several methods having been proposed in the literature. This thesis investigates the processing and analysis of MR phase imaging, proposing four novel techniques that address boundary artefacts introduced by existing phase processing methods, correct for inaccurate structural segmentation in standard SWI at high field strengths, provide optimised contrast images through the combination of magnitude and phase data, and increase accuracy in magnetic susceptibility estimation in QSM.

Subjects/Keywords: MRI; phase imaging; biomedical imaging

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APA (6^th Edition):

Ng, A. C. L. (2013). Techniques for the processing and analysis of magnetic resonance imaging phase data. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38674

Chicago Manual of Style (16^th Edition):

Ng, Amanda Ching Lih. “Techniques for the processing and analysis of magnetic resonance imaging phase data.” 2013. Doctoral Dissertation, University of Melbourne. Accessed January 24, 2021. http://hdl.handle.net/11343/38674.

MLA Handbook (7^th Edition):

Ng, Amanda Ching Lih. “Techniques for the processing and analysis of magnetic resonance imaging phase data.” 2013. Web. 24 Jan 2021.

Vancouver:

Ng ACL. Techniques for the processing and analysis of magnetic resonance imaging phase data. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/11343/38674.

Council of Science Editors:

Ng ACL. Techniques for the processing and analysis of magnetic resonance imaging phase data. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/38674

Ryerson University

7. Doganay, Ozkan. Monitoring electric field induced changes in biological tissue by using ultrasound.

Degree: 2010, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A1480

► A new effect resulting from the application of an electric field to biomaterials was discovered by analyzing ultrasound echo signals. The new effect was observed… (more)

Subjects/Keywords: Tissues – Mechanical properties; Biomedical materials – Mechanical properties; Electromagnetism – Physiological effect Ultrasonic imaging; Ultrasonics in biology

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APA (6^th Edition):

Doganay, O. (2010). Monitoring electric field induced changes in biological tissue by using ultrasound. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A1480

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Doganay, Ozkan. “Monitoring electric field induced changes in biological tissue by using ultrasound.” 2010. Thesis, Ryerson University. Accessed January 24, 2021. https://digital.library.ryerson.ca/islandora/object/RULA%3A1480.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Doganay, Ozkan. “Monitoring electric field induced changes in biological tissue by using ultrasound.” 2010. Web. 24 Jan 2021.

Vancouver:

Doganay O. Monitoring electric field induced changes in biological tissue by using ultrasound. [Internet] [Thesis]. Ryerson University; 2010. [cited 2021 Jan 24]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A1480.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Doganay O. Monitoring electric field induced changes in biological tissue by using ultrasound. [Thesis]. Ryerson University; 2010. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A1480

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Riverside

8. Burns, Joshua. Erythrocyte-Derived Optical Constructs for Biomedical Imaging and Phototherapy.

Degree: Bioengineering, 2018, University of California – Riverside

URL: http://www.escholarship.org/uc/item/9514q126

► Light-activated theranostic materials offer a potential platform for biomedical imaging and phototherapeutic applications. We have engineered constructs derived from erythrocytes, which can be doped with… (more)

▼ Light-activated theranostic materials offer a potential platform for biomedical imaging and phototherapeutic applications. We have engineered constructs derived from erythrocytes, which can be doped with the FDA-approved near infrared (NIR) dye, indocyanine green (ICG). We refer to these constructs as NIR erythrocyte-mimicking transducers (NETs) since once activated by NIR light, NETs can transduce the absorbing photons energy to generate heat, emit fluorescence, or mediate production of reactive oxygen species. In a series of studies, we examined the phototheranostic capabilities of NETs for phototherapy of port wine stains and fluorescence imaging and phototherapy of cancer. Specifically, we measured and sequentially used the optical properties of NETs to theoretically investigate the effectiveness of NETs in mediating photothermal destruction of port wine stain blood vessels. Next, we investigated the phototheranostic capabilities of NETs for fluorescence imaging and photodestruction of SKBR3 breast cancer cells and subcutaneous xenograft tumors in mice. Lastly, we present ovarian tumor imaging using NETs and spatially modulated illumination.The optical characterization and mathematical modeling results can be used in guiding the fabrication of NETs with patient-specific optical properties to allow for personalized treatment based on the depth and size of blood vessels and pigmentation of the individual’s skin. Whereas, our in vitro and in vivo results provide support for the effectiveness of NETs as theranostic agents for structured fluorescence imaging and photodestruction of tumors.Our results demonstrate that for a given NETs diameter, absorption increased over the approximate spectral band of 630–860 nm with increasing ICG concentration and that changing the ICG concentration minimally affected the scattering characteristics. Our simulation results indicated that blood vessels containing micron- or nano-sized NETs and irradiated at 755 nm had higher levels of photothermal damage as compared to blood vessels without NETs irradiated at 585 nm.In response to continuous wave 808 nm laser irradiation at intensity of 680 mW/cm2 for 10−15 min, NETs mediated the destruction of cancer cells and tumors in mice through synergistic photochemical and photothermal effects. Our spatially modulated illumination imaging results demonstrated enhanced contrast and through the use of various frequency modulations.

Subjects/Keywords: Biomedical engineering; imaging; mathematical modeling; near infrared; optical materials; phototherapy; red blood cells

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APA (6^th Edition):

Burns, J. (2018). Erythrocyte-Derived Optical Constructs for Biomedical Imaging and Phototherapy. (Thesis). University of California – Riverside. Retrieved from http://www.escholarship.org/uc/item/9514q126

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Burns, Joshua. “Erythrocyte-Derived Optical Constructs for Biomedical Imaging and Phototherapy.” 2018. Thesis, University of California – Riverside. Accessed January 24, 2021. http://www.escholarship.org/uc/item/9514q126.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Burns, Joshua. “Erythrocyte-Derived Optical Constructs for Biomedical Imaging and Phototherapy.” 2018. Web. 24 Jan 2021.

Vancouver:

Burns J. Erythrocyte-Derived Optical Constructs for Biomedical Imaging and Phototherapy. [Internet] [Thesis]. University of California – Riverside; 2018. [cited 2021 Jan 24]. Available from: http://www.escholarship.org/uc/item/9514q126.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Burns J. Erythrocyte-Derived Optical Constructs for Biomedical Imaging and Phototherapy. [Thesis]. University of California – Riverside; 2018. Available from: http://www.escholarship.org/uc/item/9514q126

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington University in St. Louis

9. Gloschat, Christopher Reed. Development of High Resolution Tools for Investigating Cardiac Arrhythmia Dynamics.

Degree: PhD, Biomedical Engineering, 2017, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/307

► Every year 300,000 Americans die due to sudden cardiac death. There are many pathologies, acquired and genetic, that can lead to sudden cardiac death.… (more)

Subjects/Keywords: arrhythmia; biomedical engineering; cardiac electrophysiology; materials for devices; optical mapping; panoramic imaging; Biomedical Engineering and Bioengineering

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APA (6^th Edition):

Gloschat, C. R. (2017). Development of High Resolution Tools for Investigating Cardiac Arrhythmia Dynamics. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/307

Chicago Manual of Style (16^th Edition):

Gloschat, Christopher Reed. “Development of High Resolution Tools for Investigating Cardiac Arrhythmia Dynamics.” 2017. Doctoral Dissertation, Washington University in St. Louis. Accessed January 24, 2021. https://openscholarship.wustl.edu/eng_etds/307.

MLA Handbook (7^th Edition):

Gloschat, Christopher Reed. “Development of High Resolution Tools for Investigating Cardiac Arrhythmia Dynamics.” 2017. Web. 24 Jan 2021.

Vancouver:

Gloschat CR. Development of High Resolution Tools for Investigating Cardiac Arrhythmia Dynamics. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2017. [cited 2021 Jan 24]. Available from: https://openscholarship.wustl.edu/eng_etds/307.

Council of Science Editors:

Gloschat CR. Development of High Resolution Tools for Investigating Cardiac Arrhythmia Dynamics. [Doctoral Dissertation]. Washington University in St. Louis; 2017. Available from: https://openscholarship.wustl.edu/eng_etds/307

Colorado State University

10. Shetye, Snehal. Development of a novel endoprosthesis for canine limb-sparing using a finite element approach.

Degree: PhD, Mechanical Engineering, 2010, Colorado State University

URL: http://hdl.handle.net/10217/45966

► Osteosarcoma is the most prevalent bone tumor in the canine population and the distal radius is the most commonly affected site. To date, amputation has… (more)

▼ Osteosarcoma is the most prevalent bone tumor in the canine population and the distal radius is the most commonly affected site. To date, amputation has been the preferred treatment option among veterinarians for distal radius osteosarcoma. However, with the advent of better chemotherapy protocols and the subsequent increasing survival rates, interest has now turned towards saving the legs of dogs with osteosarcoma. The current endoprosthesis used for limb-sparing is associated with a high failure rate, and hence, the design of a novel endoprosthesis is warranted. To aid in the development of a new endoprosthesis for canine limb-sparing a finite element model of the canine forelimb was generated. Accurate mechanical properties of soft tissues are essential to build a reliable finite element model. Since no data exists regarding the mechanical properties of canine carpal ligaments, six primary stabilizing ligaments of the canine carpus were identified and their mechanical properties were investigated by uniaxial testing in a materials testing machine. Convergence and validation are two crucial steps in the development of a finite element model. Convergence was investigated by generating three models with increasing mesh resolution. For the purposes of validation, eight intact canine forelimbs were tested in a materials testing machine. The limbs were instrumented to record bone strains and relative displacements. The acquired data were used to validate the canine forelimb model. The current endoprosthesis was evaluated to determine the mechanical underpinnings of clinical failures associated with these implants using the canine forelimb finite element model. The implant failure locations predicted by the model were similar to those observed clinically. The use of a locking plate in place of the current non-locking plate was also investigated. Several stress redistribution strategies were also examined. A novel modular design was developed in collaboration with the Colorado State University's Veterinary Teaching Hospital oncology surgeons. The design was extensively evaluated with the use of the validated and converged finite element of the canine antebrachium. The design was modified and improved based on the results. Significant stress reduction was achieved within the proximal radial screws and the distal metacarpal screws. Off-axis loading of the construct was also eliminated. The final design was approved for prototype development, biomechanical testing and cadaveric evaluation. Advisors/Committee Members: Puttlitz, Christian Matthew (advisor), James, Susan P. (committee member), Santoni, Brandon G. (committee member), Heyliger, Paul Roy, 1958- (committee member).

Subjects/Keywords: implant design; finite element modeling; endoprosthesis; canine osteosarcoma; Osteosarcoma – Treatment; Orthopedic implants – Compatibility; Dogs – Diseases; Biomedical materials – Compatibility

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APA (6^th Edition):

Shetye, S. (2010). Development of a novel endoprosthesis for canine limb-sparing using a finite element approach. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/45966

Chicago Manual of Style (16^th Edition):

Shetye, Snehal. “Development of a novel endoprosthesis for canine limb-sparing using a finite element approach.” 2010. Doctoral Dissertation, Colorado State University. Accessed January 24, 2021. http://hdl.handle.net/10217/45966.

MLA Handbook (7^th Edition):

Shetye, Snehal. “Development of a novel endoprosthesis for canine limb-sparing using a finite element approach.” 2010. Web. 24 Jan 2021.

Vancouver:

Shetye S. Development of a novel endoprosthesis for canine limb-sparing using a finite element approach. [Internet] [Doctoral dissertation]. Colorado State University; 2010. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/10217/45966.

Council of Science Editors:

Shetye S. Development of a novel endoprosthesis for canine limb-sparing using a finite element approach. [Doctoral Dissertation]. Colorado State University; 2010. Available from: http://hdl.handle.net/10217/45966

11. Sarkar, Sumona. Synthesis and characterization of a chondroitin sulfate based hybrid bio/synthetic biomimetic aggrecan macromolecule.

Degree: 2011, Drexel University

URL: http://hdl.handle.net/1860/3647

►

Lower back pain resulting from intervertebral disc degeneration is one of the leading musculoskeletal disorders confronting our health system. In order to mechanically stabilize the… (more)

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Lower back pain resulting from intervertebral disc degeneration is one of the leading musculoskeletal disorders confronting our health system. In order to mechanically stabilize the disc early in the degenerative cascade and prevent the need for spinal fusion surgeries, we have proposed the development of a hybrid-bio/synthetic biomimetic proteoglycan macromolecule for injection into the disc in the early stages of degeneration. The goal of this thesis was to incorporate natural chondroitin sulfate (CS) chains into bottle brush polymer synthesis strategies for the fabrication of CS-macromolecules which mimic the proteoglycan structure and function while resisting enzymatic degradation. Both the “grafting-to” and “grafting-through” techniques of bottle brush synthesis were explored. CS was immobilized via a terminal primary amine onto a model polymeric backbone (polyacrylic acid) for investigation of the “grafting-to” strategy and an epoxy-amine step-growth polymerization technique was utilized for the “grafting-through” synthesis of CS-macromolecules with polyethylene glycol backbone segments.Incorporation of a synthetic polymeric backbone at the terminal amine of CS was confirmed via biochemical assays, 1H-NMR and FTIR spectroscopy, and CS-macromolecule size was demonstrated to be higher than that of natural CS via gel permeation chromatography, transmission electron microscopy and viscosity measurements. Further analysis of CS-macromolecule functionality indicated maintenance of natural CS properties such as high fixed charge density, high osmotic potential and low cytotoxicity with nucleus pulposus cells.These studies are the first attempt at the incorporation of natural CS into biomimetic bottle brush structures. CS-macromolecules synthesized via the methods developed in these studies may be utilized in the treatment and prevention of debilitating back pain as well as act as mimetics for other proteoglycans implicated in cartilage, heart valve, and nervous system tissue function.

Ph.D., Biomedical Engineering – Drexel University, 2011

Advisors/Committee Members: Marcolongo, Michele.

Subjects/Keywords: Biomedical engineering; Biomedical materials; Backache

10 more images…

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APA (6^th Edition):

Sarkar, S. (2011). Synthesis and characterization of a chondroitin sulfate based hybrid bio/synthetic biomimetic aggrecan macromolecule. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/3647

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sarkar, Sumona. “Synthesis and characterization of a chondroitin sulfate based hybrid bio/synthetic biomimetic aggrecan macromolecule.” 2011. Thesis, Drexel University. Accessed January 24, 2021. http://hdl.handle.net/1860/3647.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sarkar, Sumona. “Synthesis and characterization of a chondroitin sulfate based hybrid bio/synthetic biomimetic aggrecan macromolecule.” 2011. Web. 24 Jan 2021.

Vancouver:

Sarkar S. Synthesis and characterization of a chondroitin sulfate based hybrid bio/synthetic biomimetic aggrecan macromolecule. [Internet] [Thesis]. Drexel University; 2011. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1860/3647.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sarkar S. Synthesis and characterization of a chondroitin sulfate based hybrid bio/synthetic biomimetic aggrecan macromolecule. [Thesis]. Drexel University; 2011. Available from: http://hdl.handle.net/1860/3647

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

12. Qu, Zheng. Biologically active assemblies that attenuate thrombosis on blood-contacting surfaces.

Degree: PhD, Biomedical Engineering, 2012, Georgia Tech

URL: http://hdl.handle.net/1853/50119

► All artificial organ systems and medical devices that operate in direct contact with blood elicit activation of coagulation and platelets, and their long-term use often… (more)

Subjects/Keywords: Thrombomodulin; Medical devices; Thrombosis; Biomaterials; Blood compatibility; Biomedical materials; Implants, Artificial; Biomedical engineering; Blood coagulation factors

…3.6: (A) En face and (B) fluorescent imaging of polyelectrolyte film… …imaging of polyelectrolyte film coating on the luminal surface of 4 mm i.d. ePTFE grafts… …minutes(ii). �� 56 Figure 3.8: Fluorescent imaging of 16-bilayer PEI/heaprin film… …configuration for testing thrombogenicity of 4 mm i.d. tubular materials. (b) Representative… …the modified catheter was monitored using the Maestro multi-spectral fluorescence imaging…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Qu, Z. (2012). Biologically active assemblies that attenuate thrombosis on blood-contacting surfaces. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/50119

Chicago Manual of Style (16^th Edition):

Qu, Zheng. “Biologically active assemblies that attenuate thrombosis on blood-contacting surfaces.” 2012. Doctoral Dissertation, Georgia Tech. Accessed January 24, 2021. http://hdl.handle.net/1853/50119.

MLA Handbook (7^th Edition):

Qu, Zheng. “Biologically active assemblies that attenuate thrombosis on blood-contacting surfaces.” 2012. Web. 24 Jan 2021.

Vancouver:

Qu Z. Biologically active assemblies that attenuate thrombosis on blood-contacting surfaces. [Internet] [Doctoral dissertation]. Georgia Tech; 2012. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1853/50119.

Council of Science Editors:

Qu Z. Biologically active assemblies that attenuate thrombosis on blood-contacting surfaces. [Doctoral Dissertation]. Georgia Tech; 2012. Available from: http://hdl.handle.net/1853/50119

University of Oxford

13. Tsou, Nien-Ti. Compatible domain structures in ferroelectric single crystals.

Degree: PhD, 2011, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:2ef69e2d-ec5a-4e1b-814f-b573b1649a58 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558335

► The aim of the current study is to develop an efficient model which can predict low-energy compatible microstructures in ferroelectric bulks and film devices and… (more)

▼ The aim of the current study is to develop an efficient model which can predict low-energy compatible microstructures in ferroelectric bulks and film devices and their dynamic behaviour. The results are expected to assist in the interpretation of microstructure observations and provide a knowledge of the possible domain arrangements that can be used to design future materials with optimum performance. Several recent models of ferroelectric crystals assume low energy domain configurations. They are mainly based on the idea of fine phase mixtures and average compatibility, and can require intensive computation resulting in complex domain configurations which rarely occur in nature. In this research, criteria for the exact compatibility of domain structure in the form of a periodic multi-rank laminate are developed. Exactly compatible structure is expected to be energetically favourable and does not require the concept of a fine mixture to eliminate incompatibilities. The resulting method is a rapid and systematic procedure for finding exactly compatible microstructures. This is then used to explore minimum rank compatible microstructure in various crystal systems and devices. The results reveal routes in polarization and strain spaces along which microstructure can continuously evolve, including poling paths for ferro- electric single crystals. Also, the method is capable to generate all possible exactly compatible laminate configurations for given boundary conditions. It is found that simple configurations are often energetically favourable in conditions where previous approaches would predict more complex domain patterns. Laminate domain patterns in ferroelectrics are classified and corre- lated with observations of domains in single crystals, showing good agreement. The evolution of microstructures under applied mechanical and electrical loads is studied. A variational method, which minimises the overall energy of the crystal is developed. A new concept of transitional “pivot states” is introduced which allows the model to capture the feature that the microstructure in ferroelectric crystal switches between possible domain patterns that are energetically favourable, rather than assuming one particular domain pattern throughout. This model is applied to study the hysteresis responses of barium titanate (BaTiO3) single crystals subjected to a variety of loads. The results have good agreement with experimental data in the literature. The relationship between domain patterns and ferroelectric hysteresis responses is discussed.

Subjects/Keywords: 548.85; Materials modelling; Solid mechanics; Materials engineering; Ceramics; ferroelectric; microstructure; compatibility

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APA (6^th Edition):

Tsou, N. (2011). Compatible domain structures in ferroelectric single crystals. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:2ef69e2d-ec5a-4e1b-814f-b573b1649a58 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558335

Chicago Manual of Style (16^th Edition):

Tsou, Nien-Ti. “Compatible domain structures in ferroelectric single crystals.” 2011. Doctoral Dissertation, University of Oxford. Accessed January 24, 2021. http://ora.ox.ac.uk/objects/uuid:2ef69e2d-ec5a-4e1b-814f-b573b1649a58 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558335.

MLA Handbook (7^th Edition):

Tsou, Nien-Ti. “Compatible domain structures in ferroelectric single crystals.” 2011. Web. 24 Jan 2021.

Vancouver:

Tsou N. Compatible domain structures in ferroelectric single crystals. [Internet] [Doctoral dissertation]. University of Oxford; 2011. [cited 2021 Jan 24]. Available from: http://ora.ox.ac.uk/objects/uuid:2ef69e2d-ec5a-4e1b-814f-b573b1649a58 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558335.

Council of Science Editors:

Tsou N. Compatible domain structures in ferroelectric single crystals. [Doctoral Dissertation]. University of Oxford; 2011. Available from: http://ora.ox.ac.uk/objects/uuid:2ef69e2d-ec5a-4e1b-814f-b573b1649a58 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558335

Washington University in St. Louis

14. Hai, Pengfei. Photoacoustic Elastography and Next-generation Photoacoustic Tomography Techniques Towards Clinical Translation.

Degree: PhD, Biomedical Engineering, 2018, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/eng_etds/325

► Ultrasonically probing optical absorption, photoacoustic tomography (PAT) combines rich optical contrast with high ultrasonic resolution at depths beyond the optical diffusion limit. With consistent… (more)

▼ Ultrasonically probing optical absorption, photoacoustic tomography (PAT) combines rich optical contrast with high ultrasonic resolution at depths beyond the optical diffusion limit. With consistent optical absorption contrast at different scales and highly scalable spatial resolution and penetration depth, PAT holds great promise as an important tool for both fundamental research and clinical application. Despite tremendous progress, PAT still encounters certain limitations that prevent it from becoming readily adopted in the clinical settings. This dissertation aims to advance both the technical development and application of PAT towards its clinical translation. The first part of this dissertation describes the development of photoacoustic elastography techniques, which complement PAT with the capability to image the elastic properties of biological tissue and detect pathological conditions associated with its alterations. First, I demonstrated vascular-elastic PAT (VE-PAT), capable of quantifying blood vessel compliance changes due to thrombosis and occlusions. Then, I developed photoacoustic elastography to noninvasively map the elasticity distribution in biological tissue. Third, I further enhanced its performance by combing conventional photoacoustic elastography with a stress sensor having known stress–strain behavior to achieve quantitative photoacoustic elastography (QPAE). QPAE can quantify the Young’s modulus of biological tissues on an absolute scale. The second part of this dissertation introduces technical improvements of photoacoustic microscopy (PAM). First, by employing near-infrared (NIR) light for illumination, a greater imaging depth and finer lateral resolution were achieved by near-infrared optical-resolution PAM (NIR-OR-PAM). In addition, NIR-OR-PAM was capable of imaging other tissue components, including lipid and melanin. Second, I upgraded a high-speed functional OR-PAM (HF-OR-PAM) system and applied it to image neurovascular coupling during epileptic seizure propagation in mouse brains in vivo with high spatio-temporal resolution. Last, I developed a single-cell metabolic PAM (SCM-PAM) system, which improves the current single-cell oxygen consumption rate (OCR) measurement throughput from ~30 cells over 15 minutes to ~3000 cells over 15 minutes. This throughput enhancement of two orders of magnitude achieves modeling of single-cell OCR distribution with a statistically meaningful cell count. SCM-PAM enables imaging of intratumoral metabolic heterogeneity with single-cell resolution. The third part of this dissertation introduces the application of linear-array-based PAT (LA-PAT) in label-free high-throughput imaging of melanoma circulating tumor cells (CTCs) in patients in vivo. Taking advantage of the strong optical absorption of melanin and the unique capability of PAT to image optical absorption, with 100% relative sensitivity, at depths with high ultrasonic spatial resolution, LA-PAT is inherently suitable for melanoma CTC imaging. First, with a center ultrasonic… Advisors/Committee Members: Lihong V. Wang, Mark Anastasio, Philip V. Bayly, Jin-Moo Lee, James G. Miller.

Subjects/Keywords: Biomedical imaging; Elastography; Optical imaging; Photoacoustic imaging; Biomedical Engineering and Bioengineering

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APA (6^th Edition):

Hai, P. (2018). Photoacoustic Elastography and Next-generation Photoacoustic Tomography Techniques Towards Clinical Translation. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/eng_etds/325

Chicago Manual of Style (16^th Edition):

Hai, Pengfei. “Photoacoustic Elastography and Next-generation Photoacoustic Tomography Techniques Towards Clinical Translation.” 2018. Doctoral Dissertation, Washington University in St. Louis. Accessed January 24, 2021. https://openscholarship.wustl.edu/eng_etds/325.

MLA Handbook (7^th Edition):

Hai, Pengfei. “Photoacoustic Elastography and Next-generation Photoacoustic Tomography Techniques Towards Clinical Translation.” 2018. Web. 24 Jan 2021.

Vancouver:

Hai P. Photoacoustic Elastography and Next-generation Photoacoustic Tomography Techniques Towards Clinical Translation. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2018. [cited 2021 Jan 24]. Available from: https://openscholarship.wustl.edu/eng_etds/325.

Council of Science Editors:

Hai P. Photoacoustic Elastography and Next-generation Photoacoustic Tomography Techniques Towards Clinical Translation. [Doctoral Dissertation]. Washington University in St. Louis; 2018. Available from: https://openscholarship.wustl.edu/eng_etds/325

Drexel University

15. Fan, Zhiyuan. Cell Membrane-Derived Materials.

Degree: 2018, Drexel University

URL: http://hdl.handle.net/1860/idea:11340

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Biological materials are superior to synthetic biomaterials in biocompatibility and active interactions with cells. Recently, cell membrane-derived nanomaterials (CM-NMs) have been actively explored as a… (more)

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Biological materials are superior to synthetic biomaterials in biocompatibility and active interactions with cells. Recently, cell membrane-derived nanomaterials (CM-NMs) have been actively explored as a novel class of biological materials with various biomedical applications. However, the fundamental properties of CM-NMs were rarely studied. We first designed new methods to quantitatively study the membrane orientation of red blood cell membrane-coated nanoparticles (RBCM NPs) by conjugating ssDNA probes on cell membranes and cell membrane permeability by a nitrobenzoxadiazole-dithionite ion quenching system. We have demonstrated that membranes maintained a correct outside-out orientation on the majority of NPs, and RBCM NPs have a higher permeability to dithionite ions compared with liposomes and live RBCs. Next, we investigated the effect of cell membrane coating on reducing acute inflammatory responses induced by poly(lactic-co-glycolic acid) NPs to scaffold constructs. The release of therapeutics from the NPs is an important strategy to program cells inside the scaffolds for applications in tissue regeneration and immune modulation. We have demonstrated that coating RBC membranes around NPs can eliminate the NP-induced short-term inflammatory responses to scaffolds, including dramatically increased neutrophil infiltration and pro-inflammatory cytokines. We further developed a new class of biological materials: cell membrane-derived hydrogel scaffolds by using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide-activated alginate to crosslink RBCM vesicles. We have demonstrated that RBCM scaffolds can encapsulate hydrophobic molecules and have the potential to release hydrophobic drugs in a sustained manner. RBCM scaffolds show low neutrophil infiltration after subcutaneous injection in mice, and a significantly higher number of infiltrated macrophages than methacrylate alginate (MA-alginate) scaffolds. According to gene expression and surface markers, these macrophages have an M2-like phenotype, which is anti-inflammatory and immune suppressive. There are also higher percentages of macrophages presenting immunosuppressive PD-L1 in RBCM-scaffolds than in MA-alginate scaffolds. Interestingly, the concentrations of an anti-inflammatory cytokine, IL-10 in both types of scaffolds are higher than those in normal organ tissues. This study paves the way to explore scaffolds derived from other cells that present receptors and/or contain cytokines in regulating immune cells or cells critical for tissue regeneration.

Ph.D., Materials Science and Engineering – Drexel University, 2018

Advisors/Committee Members: Cheng, Hao, College of Engineering.

Subjects/Keywords: Materials science; Biomedical materials

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APA (6^th Edition):

Fan, Z. (2018). Cell Membrane-Derived Materials. (Thesis). Drexel University. Retrieved from http://hdl.handle.net/1860/idea:11340

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fan, Zhiyuan. “Cell Membrane-Derived Materials.” 2018. Thesis, Drexel University. Accessed January 24, 2021. http://hdl.handle.net/1860/idea:11340.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fan, Zhiyuan. “Cell Membrane-Derived Materials.” 2018. Web. 24 Jan 2021.

Vancouver:

Fan Z. Cell Membrane-Derived Materials. [Internet] [Thesis]. Drexel University; 2018. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1860/idea:11340.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fan Z. Cell Membrane-Derived Materials. [Thesis]. Drexel University; 2018. Available from: http://hdl.handle.net/1860/idea:11340

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Florida State University

16. Wu, Jinsong. PP2A and Casein Kinases Regulate SWE1 Degradation Through HSL1 and HSL7.

Degree: MS, Biomedical Sciences, 2010, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-0698 ;

►

In mammalian cells, cyclin dependent kinase (CDK) is subjected to negative regulation by a conserved kinase, Wee1. In budding yeast, S. cerevisiae, Swe1 kinase, the… (more)

Subjects/Keywords: Biomedical materials; Dental materials

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APA (6^th Edition):

Wu, J. (2010). PP2A and Casein Kinases Regulate SWE1 Degradation Through HSL1 and HSL7. (Masters Thesis). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-0698 ;

Chicago Manual of Style (16^th Edition):

Wu, Jinsong. “PP2A and Casein Kinases Regulate SWE1 Degradation Through HSL1 and HSL7.” 2010. Masters Thesis, Florida State University. Accessed January 24, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-0698 ;.

MLA Handbook (7^th Edition):

Wu, Jinsong. “PP2A and Casein Kinases Regulate SWE1 Degradation Through HSL1 and HSL7.” 2010. Web. 24 Jan 2021.

Vancouver:

Wu J. PP2A and Casein Kinases Regulate SWE1 Degradation Through HSL1 and HSL7. [Internet] [Masters thesis]. Florida State University; 2010. [cited 2021 Jan 24]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-0698 ;.

Council of Science Editors:

Wu J. PP2A and Casein Kinases Regulate SWE1 Degradation Through HSL1 and HSL7. [Masters Thesis]. Florida State University; 2010. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-0698 ;

Ryerson University

17. Bhatt, Jagdish. Monitoring electric field induced changes in biological tissues and phantoms using ultrasound.

Degree: 2015, Ryerson University

URL: https://digital.library.ryerson.ca/islandora/object/RULA%3A3767

► An external electric field can induce mechanical changes depending on the amplitude, frequency and duration of the applied electric field. This study is focused on… (more)

Subjects/Keywords: Tissues – Mechanical properties; Biomedical materials – Mechanical properties; Ultrasonic waves – Physiological effect; Electromagnetism – Physiological effect; Tomography; Ultrasonic imaging; Ultrasonics in biology

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APA (6^th Edition):

Bhatt, J. (2015). Monitoring electric field induced changes in biological tissues and phantoms using ultrasound. (Thesis). Ryerson University. Retrieved from https://digital.library.ryerson.ca/islandora/object/RULA%3A3767

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bhatt, Jagdish. “Monitoring electric field induced changes in biological tissues and phantoms using ultrasound.” 2015. Thesis, Ryerson University. Accessed January 24, 2021. https://digital.library.ryerson.ca/islandora/object/RULA%3A3767.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bhatt, Jagdish. “Monitoring electric field induced changes in biological tissues and phantoms using ultrasound.” 2015. Web. 24 Jan 2021.

Vancouver:

Bhatt J. Monitoring electric field induced changes in biological tissues and phantoms using ultrasound. [Internet] [Thesis]. Ryerson University; 2015. [cited 2021 Jan 24]. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3767.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bhatt J. Monitoring electric field induced changes in biological tissues and phantoms using ultrasound. [Thesis]. Ryerson University; 2015. Available from: https://digital.library.ryerson.ca/islandora/object/RULA%3A3767

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Rutgers University

18. Drzewiecki, Kathryn Emily, 1989-. Collagen methacrylamide - a photocrosslinkable, thermoreversible collagen-based biomaterial: characterization and applications.

Degree: PhD, Biomedical Engineering, 2016, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/51271/

►

Ideal properties of biomaterials for tissue engineering applications include biocompatibility, tissue mimicry, the ability to support cell attachment and growth, biodegradability, and control of biochemical… (more)

▼

Ideal properties of biomaterials for tissue engineering applications include biocompatibility, tissue mimicry, the ability to support cell attachment and growth, biodegradability, and control of biochemical and mechanical properties. Type-I collagen, a protein found throughout many tissues throughout the body, can be extracted from animal tissue and used to make fibrillar hydrogels or scaffolds for tissue engineering. While these collagen scaffolds have many of the optimal design parameters for biomaterials, the lack of control of scaffold properties is highly disadvantageous for its use in new tissue engineering paradigms. Previous studies have focused on developing a photoreactive collagen that could be biochemically and mechanically tuned via the application of light by functionalizing collagen with methacrylic acid to create collagen methacrylamide (CMA). This dissertation focuses on the characterization, continued development, and applications of CMA as a collagen-based biomaterial for tissue engineering. We demonstrated that fibrillogenesis of CMA, in contrast to type-I collagen, is thermoreversible. CMA can reversibly cycle between two states: it ii forms fibrillar hydrogels at 37 Â°C, and disassembles into a liquid suspension at temperatures less than 10 Â°C. The CMA synthesis procedure was revisited to better understand how methacrylation caused thermoreversibility. Of two methods used for conjugation, one results in a thermoreversible collagen. Thermoreversibility was not specific to the methacrylic acid - other compounds were conjugated and found to make collagen thermoreversible. In using circular dichroism spectroscopy to characterize the temperature-dependent protein structure of collagen, we found that collagen fibrils were displayed a unique signal; the fibril spectrum was seen as a negative peak at ~204 nm in contrast to the triple-helix signal in collagen's monomeric form that is characterized by a positive peak at ~222 nm. This signal was exclusive to the collagen fibril, and was used it as a tool to monitor collagen fibrillogenesis among other changes in collagen higher order structure Finally, we developed a method of free-form fabrication of CMA, where hydrogels are constructed through self-assembly, photocrosslinking of specific geometries, and cold-melted to remove regions that were not exposed to light. Customized hydrogels can be fabricated with or without cells, or further processed into sponges. Hydrogels were also shown to be biocompatible in a subcutaneous implant model. In comparison to many 3D printing strategies, CMA free-form fabrication is very simple to implement and is inexpensive, prompting continued development of CMA in tissue engineering and regenerative medicine.

Advisors/Committee Members: Shreiber, David I (chair), Nanda, Vikas (internal member), Berthiaume, Francois (internal member), Baum, Jean (internal member), Kemnitzer, John (outside member).

Subjects/Keywords: Collagen; Biomedical materials

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APA (6^th Edition):

Drzewiecki, Kathryn Emily, 1. (2016). Collagen methacrylamide - a photocrosslinkable, thermoreversible collagen-based biomaterial: characterization and applications. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/51271/

Chicago Manual of Style (16^th Edition):

Drzewiecki, Kathryn Emily, 1989-. “Collagen methacrylamide - a photocrosslinkable, thermoreversible collagen-based biomaterial: characterization and applications.” 2016. Doctoral Dissertation, Rutgers University. Accessed January 24, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/51271/.

MLA Handbook (7^th Edition):

Drzewiecki, Kathryn Emily, 1989-. “Collagen methacrylamide - a photocrosslinkable, thermoreversible collagen-based biomaterial: characterization and applications.” 2016. Web. 24 Jan 2021.

Vancouver:

Drzewiecki, Kathryn Emily 1. Collagen methacrylamide - a photocrosslinkable, thermoreversible collagen-based biomaterial: characterization and applications. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2021 Jan 24]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51271/.

Council of Science Editors:

Drzewiecki, Kathryn Emily 1. Collagen methacrylamide - a photocrosslinkable, thermoreversible collagen-based biomaterial: characterization and applications. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/51271/

Rutgers University

19. Dube, Koustubh Shishir, 1986-. Advanced molecular design to replace poly(α-hydroxy acid)s in biomedical applications.

Degree: PhD, Chemistry and Chemical Biology, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/52141/

►

Advances in biomaterials can be brought about by the development of novel polymers that are designed to satisfy multiple criteria. Some of these criteria are… (more)

Subjects/Keywords: Biomedical materials; Polymers

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APA (6^th Edition):

Dube, Koustubh Shishir, 1. (2017). Advanced molecular design to replace poly(α-hydroxy acid)s in biomedical applications. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/52141/

Chicago Manual of Style (16^th Edition):

Dube, Koustubh Shishir, 1986-. “Advanced molecular design to replace poly(α-hydroxy acid)s in biomedical applications.” 2017. Doctoral Dissertation, Rutgers University. Accessed January 24, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/52141/.

MLA Handbook (7^th Edition):

Dube, Koustubh Shishir, 1986-. “Advanced molecular design to replace poly(α-hydroxy acid)s in biomedical applications.” 2017. Web. 24 Jan 2021.

Vancouver:

Dube, Koustubh Shishir 1. Advanced molecular design to replace poly(α-hydroxy acid)s in biomedical applications. [Internet] [Doctoral dissertation]. Rutgers University; 2017. [cited 2021 Jan 24]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/52141/.

Council of Science Editors:

Dube, Koustubh Shishir 1. Advanced molecular design to replace poly(α-hydroxy acid)s in biomedical applications. [Doctoral Dissertation]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/52141/

Rutgers University

20. SARHAN, AHMED, 1979-. Sol-gel synthesis of calcium phosphate powders.

Degree: PhD, Materials Science and Engineering, 2019, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/60053/

► Materials that are used for biomedical or clinical applications are known as biomaterials. These materials are made in different forms according to their functionality and… (more)

▼ Materials that are used for biomedical or clinical applications are known as biomaterials. These materials are made in different forms according to their functionality and the body part they will repair. Biocompatibility, biofunctionality, and bioavailability are three significant factors in selecting these materials, as they might be bioinert, resorbable, or bioactive like hydroxyapatite. Hydroxyapatite (HAp), chemical formula Ca10(PO4)6(OH)2, having a calcium to phosphorus ratio of 1.667, has received special interest in the field of biomaterials as it is well known to be an inorganic bioactive material capable of forming chemical bonds with bones and teeth, besides promoting tissue engineering and bone growth for the treatment of infected or damaged organs. It is chemically and crystallographically similar to the main minerals in bones, dentin, and enamel where no toxicity or inflammation of a foreign body response has occurred. Affinities of biopolymers, and the high osteogenic potential of promoting bone in-growth and osteoconduction, are common reasons for synthetic HAp to dominate the field of biomaterials. HAp ceramics are mostly limited to applications of low mechanical loads. In use, this may mean that the HAp is used in conjunction with a polymer in a composite. Consideration is given to using HAp powders in 3D printing. By using 3D printing, it is possible to control the pore size and pore distribution of composite scaffolds. Since the characteristics of the HAp powders influence the ability to print bone scaffolds, it is interesting to compare their properties. There are numerous synthesis methods and approaches to produce HAp. In this study, hydroxyapatite is prepared by the sol-gel method, where precursors are subjected to high temperatures treatment after a gel-like network is formed. These powders are compared to HAp prepared by the hydrothermal method, where the precursors react in an aqueous solution under high temperature and pressure to synthesize HAp crystals. Both materials have been studied in comparison to a commercial HAp powder obtained from a manufacturer (FLUIDINOVA, S.A). This study focuses on the differences of preparation methodology, the resulting microstructures, phase composition, particle size and crystallinity. The sol-gel method provided a homogeneous molecular mixing at a low processing temperature (<95°C). The resulting apatite structure mainly depended on the choice of the precursors and the sintering temperature. For comparison, the hydrothermal technique produced crystalline HAp in one step without requiring post heat treatment to crystallize. HAp formed directly from the aqueous solution in a sealed vessel at high pressure and temperature of 150°C. Phase identification by X-ray diffraction analysis, microstructure analysis (FESEM), nitrogen surface area (BET), particle size, differential thermal analysis was performed on the samples of the HAp powders. Higher crystallinity, higher surface area, high pore volume, a narrow range of particle sizes, and a… Advisors/Committee Members: Klein, Lisa Carol (chair), Safari, Ahmad (internal member), Mann, Adrian (internal member), Goel, Ashutosh (internal member), Jitianu, Andrei (outside member), School of Graduate Studies.

Subjects/Keywords: Biomedical materials – Synthesis

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APA (6^th Edition):

SARHAN, AHMED, 1. (2019). Sol-gel synthesis of calcium phosphate powders. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/60053/

Chicago Manual of Style (16^th Edition):

SARHAN, AHMED, 1979-. “Sol-gel synthesis of calcium phosphate powders.” 2019. Doctoral Dissertation, Rutgers University. Accessed January 24, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/60053/.

MLA Handbook (7^th Edition):

SARHAN, AHMED, 1979-. “Sol-gel synthesis of calcium phosphate powders.” 2019. Web. 24 Jan 2021.

Vancouver:

SARHAN, AHMED 1. Sol-gel synthesis of calcium phosphate powders. [Internet] [Doctoral dissertation]. Rutgers University; 2019. [cited 2021 Jan 24]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/60053/.

Council of Science Editors:

SARHAN, AHMED 1. Sol-gel synthesis of calcium phosphate powders. [Doctoral Dissertation]. Rutgers University; 2019. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/60053/

Rutgers University

21. Stanton, John, 1991-. Structure property relationships of carbohydrate/protein based biomaterials.

Degree: MS, Chemistry, 2017, Rutgers University

URL: https://rucore.libraries.rutgers.edu/rutgers-lib/52890/

► Cellulose and silk blended biomaterial films were regenerated from ionic liquid solutions and investigated to characterize and understand the effect of inter- and intra-molecular interactions… (more)

Subjects/Keywords: Biomedical materials; Cellulose

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APA (6^th Edition):

Stanton, John, 1. (2017). Structure property relationships of carbohydrate/protein based biomaterials. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/52890/

Chicago Manual of Style (16^th Edition):

Stanton, John, 1991-. “Structure property relationships of carbohydrate/protein based biomaterials.” 2017. Masters Thesis, Rutgers University. Accessed January 24, 2021. https://rucore.libraries.rutgers.edu/rutgers-lib/52890/.

MLA Handbook (7^th Edition):

Stanton, John, 1991-. “Structure property relationships of carbohydrate/protein based biomaterials.” 2017. Web. 24 Jan 2021.

Vancouver:

Stanton, John 1. Structure property relationships of carbohydrate/protein based biomaterials. [Internet] [Masters thesis]. Rutgers University; 2017. [cited 2021 Jan 24]. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/52890/.

Council of Science Editors:

Stanton, John 1. Structure property relationships of carbohydrate/protein based biomaterials. [Masters Thesis]. Rutgers University; 2017. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/52890/

The Ohio State University

22. Huang, Jiwei. Multispectral Imaging of Skin Oxygenation.

Degree: PhD, Biophysics, 2012, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1356637098

► This research focuses on the investigation of a multispectral imaging technique for quantitative measurement of skin tissue oxygen saturation (StO2). Oxygen saturation is the percentage… (more)

▼ This research focuses on the investigation of a multispectral imaging technique for quantitative measurement of skin tissue oxygen saturation (StO2). Oxygen saturation is the percentage of oxygen carried in the blood over the total oxygen carrying capacity of blood. Skin StO2 is an important indicator of skin tissue clinical status. Measurement of skin tissue oxygenation has been in many clinical applications such as cosmetic product development, chronic wound care and plastic surgery tissue recovery monitoring. For decades, researchers have been investigating optical spectroscopy and imaging techniques for measuring tissue oxygen saturation. However, many existing techniques are subjective and qualitative due to background bias, tissue heterogeneity, and inter-patient variation. A technique for quantitative and reliable measurement of skin tissue oxygen saturation is necessary. Multispectral / hyperspectral imaging is a promising technique which has been proposed for quantitative measurement of skin StO2 by capturing and analyzing skin images at multiple wavelengths.This dissertation reports a multispectral imaging method which is capable of (1) quantitative measurement of skin oxygen saturation with minimal bias from different skin types, and (2) imaging skin oxygen saturation dynamics. There’re mainly three parts of this research.First, theoretical study and algorithm development. A numerical model was established to simulate skin tissue reflectance of different skin conditions including oxygen saturation, blood concentration, tissue scattering and melanin concentration. From the simulation result, a parameter SDR, which can be calculated from skin reflectance images of 544, 552, 568, 576, 592, 600nm, was found to be mainly determined by oxygenation regardless of different tissue conditions. Thus, skin oxygen saturation can be measured by taking multispectral images of six wavelengths. Second, imaging system development. A multispectral / hyperspectral imaging system was built by integrating camera, filter and light source. A graphical user interface was developed for equipment control, synchronization and image acquisition. Imaging processing algorithm was developed for generation of skin oxygen saturation map from the reflectance image of six wavelengths. Third, benchtop experiments and human subject test. The imaging method was first verified using a phantom which was a liquid mixture of different concentrations of blood, intralipid and ink to simulate different skin conditions. StO2 measured by our method was not affected by the different concentration of phantom materials. Then, multispectral imaging of skin oxygenation was demonstrated by a human subject test in which 10 subjects with different skin types were recruited. The variation of skin StO2(%) measured by multispectral imaging is over two times smaller than the measurements from other two oximetry techniques, which indicates that skin StO2 measurement by our method is not affected by different skin types. After that, skin StO2 dynamics was measured… Advisors/Committee Members: Xu, Ronald (Committee Chair).

Subjects/Keywords: Biomedical Engineering; Biomedical Research; Medical Imaging; Optics

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APA (6^th Edition):

Huang, J. (2012). Multispectral Imaging of Skin Oxygenation. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1356637098

Chicago Manual of Style (16^th Edition):

Huang, Jiwei. “Multispectral Imaging of Skin Oxygenation.” 2012. Doctoral Dissertation, The Ohio State University. Accessed January 24, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1356637098.

MLA Handbook (7^th Edition):

Huang, Jiwei. “Multispectral Imaging of Skin Oxygenation.” 2012. Web. 24 Jan 2021.

Vancouver:

Huang J. Multispectral Imaging of Skin Oxygenation. [Internet] [Doctoral dissertation]. The Ohio State University; 2012. [cited 2021 Jan 24]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1356637098.

Council of Science Editors:

Huang J. Multispectral Imaging of Skin Oxygenation. [Doctoral Dissertation]. The Ohio State University; 2012. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1356637098

23. Lakhotia, Kritika. Visualization and quantification of 3D tumor-host interface architecture reconstructed from digital histopathology slides.

Degree: 2016, State University of New York at Buffalo

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10127616

► Oral cavity cancer (OCC) is a type of cancer of the lip, tongue, salivary glands and other sites in the mouth (buccal or oral… (more)

Subjects/Keywords: Biomedical engineering; Medical imaging

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APA (6^th Edition):

Lakhotia, K. (2016). Visualization and quantification of 3D tumor-host interface architecture reconstructed from digital histopathology slides. (Thesis). State University of New York at Buffalo. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10127616

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lakhotia, Kritika. “Visualization and quantification of 3D tumor-host interface architecture reconstructed from digital histopathology slides.” 2016. Thesis, State University of New York at Buffalo. Accessed January 24, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=10127616.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lakhotia, Kritika. “Visualization and quantification of 3D tumor-host interface architecture reconstructed from digital histopathology slides.” 2016. Web. 24 Jan 2021.

Vancouver:

Lakhotia K. Visualization and quantification of 3D tumor-host interface architecture reconstructed from digital histopathology slides. [Internet] [Thesis]. State University of New York at Buffalo; 2016. [cited 2021 Jan 24]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10127616.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lakhotia K. Visualization and quantification of 3D tumor-host interface architecture reconstructed from digital histopathology slides. [Thesis]. State University of New York at Buffalo; 2016. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10127616

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Vaidya, Manushka. Steering Electromagnetic Fields in MRI| Investigating Radiofrequency Field Interactions with Endogenous and External Dielectric Materials for Improved Coil Performance at High Field.

Degree: 2017, New York University

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10261392

► Although 1.5 and 3 Tesla (T) magnetic resonance (MR) systems remain the clinical standard, the number of 7 T MR systems has increased over… (more)

▼ Although 1.5 and 3 Tesla (T) magnetic resonance (MR) systems remain the clinical standard, the number of 7 T MR systems has increased over the past decade because of the promise of higher signal-to-noise ratio (SNR), which can translate to images with higher resolution, improved image quality and faster acquisition times. However, there are a number of technical challenges that have prevented exploiting the full potential of ultra-high field (≥ 7 T) MR imaging (MRI), such as the inhomogeneous distribution of the radiofrequency (RF) electromagnetic field and specific energy absorption rate (SAR), which can compromise image quality and patient safety. To better understand the origin of these issues, we first investigated the dependence of the spatial distribution of the magnetic field associated with a surface RF coil on the operating frequency and electrical properties of the sample. Our results demonstrated that the asymmetries between the transmit (B₁⁺) and receive (B₁–) circularly polarized components of the magnetic field, which are in part responsible for RF inhomogeneity, depend on the electric conductivity of the sample. On the other hand, when sample conductivity is low, a high relative permittivity can result in an inhomogeneous RF field distribution, due to significant constructive and destructive interference patterns between forward and reflected propagating magnetic field within the sample. We then investigated the use of high permittivity materials (HPMs) as a method to alter the field distribution and improve transmit and receive coil performance in MRI. We showed that HPM placed at a distance from an RF loop coil can passively shape the field within the sample. Our results showed improvement in transmit and receive sensitivity overlap, extension of coil field-of-view, and enhancement in transmit/receive efficiency. We demonstrated the utility of this concept by employing HPM to improve performance of an existing commercial head coil for the inferior regions of the brain, where the specific coil’s imaging efficiency was inherently poor. Results showed a gain in SNR, while the maximum local and head SAR values remained below the prescribed limits. We showed that increasing coil performance with HPM could improve detection of functional MR activation during a motor-based task for whole brain fMRI. Finally, to gain an intuitive understanding of how HPM improves coil performance, we investigated how HPM separately affects signal and noise sensitivity to improve SNR. For this purpose, we employed a theoretical model based on dyadic Green’s functions to compare the characteristics of current patterns, i.e. the optimal spatial distribution of coil conductors, that would either maximize SNR (ideal current patterns), maximize signal reception (signal-only optimal current patterns), or minimize sample noise (dark mode current patterns). Our results demonstrated that the presence of a lossless HPM…

Subjects/Keywords: Biomedical engineering; Medical imaging; Physics

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APA (6^th Edition):

Vaidya, M. (2017). Steering Electromagnetic Fields in MRI| Investigating Radiofrequency Field Interactions with Endogenous and External Dielectric Materials for Improved Coil Performance at High Field. (Thesis). New York University. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10261392

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vaidya, Manushka. “Steering Electromagnetic Fields in MRI| Investigating Radiofrequency Field Interactions with Endogenous and External Dielectric Materials for Improved Coil Performance at High Field.” 2017. Thesis, New York University. Accessed January 24, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=10261392.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vaidya, Manushka. “Steering Electromagnetic Fields in MRI| Investigating Radiofrequency Field Interactions with Endogenous and External Dielectric Materials for Improved Coil Performance at High Field.” 2017. Web. 24 Jan 2021.

Vancouver:

Vaidya M. Steering Electromagnetic Fields in MRI| Investigating Radiofrequency Field Interactions with Endogenous and External Dielectric Materials for Improved Coil Performance at High Field. [Internet] [Thesis]. New York University; 2017. [cited 2021 Jan 24]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10261392.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vaidya M. Steering Electromagnetic Fields in MRI| Investigating Radiofrequency Field Interactions with Endogenous and External Dielectric Materials for Improved Coil Performance at High Field. [Thesis]. New York University; 2017. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10261392

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Irvine

25. Le, Vivian. Self-Assembly of an Optically-Responsive Polydiacetylene-Coating on Iron Ferrite Magnetic Nanoparticles for Tumor Detection and Targeting.

Degree: Chemical and Biochemical Engineering, 2016, University of California – Irvine

URL: http://www.escholarship.org/uc/item/066162xs

► Nanoparticles are a promising diagnostic agent with applications in tumor imaging and targeted cancer treatment. They can offer multifunctional properties by combining imaging methods to… (more)

Subjects/Keywords: Nanotechnology; Biomedical engineering; Medical imaging

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APA (6^th Edition):

Le, V. (2016). Self-Assembly of an Optically-Responsive Polydiacetylene-Coating on Iron Ferrite Magnetic Nanoparticles for Tumor Detection and Targeting. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/066162xs

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Le, Vivian. “Self-Assembly of an Optically-Responsive Polydiacetylene-Coating on Iron Ferrite Magnetic Nanoparticles for Tumor Detection and Targeting.” 2016. Thesis, University of California – Irvine. Accessed January 24, 2021. http://www.escholarship.org/uc/item/066162xs.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Le, Vivian. “Self-Assembly of an Optically-Responsive Polydiacetylene-Coating on Iron Ferrite Magnetic Nanoparticles for Tumor Detection and Targeting.” 2016. Web. 24 Jan 2021.

Vancouver:

Le V. Self-Assembly of an Optically-Responsive Polydiacetylene-Coating on Iron Ferrite Magnetic Nanoparticles for Tumor Detection and Targeting. [Internet] [Thesis]. University of California – Irvine; 2016. [cited 2021 Jan 24]. Available from: http://www.escholarship.org/uc/item/066162xs.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Le V. Self-Assembly of an Optically-Responsive Polydiacetylene-Coating on Iron Ferrite Magnetic Nanoparticles for Tumor Detection and Targeting. [Thesis]. University of California – Irvine; 2016. Available from: http://www.escholarship.org/uc/item/066162xs

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

26. Croft, Laura Rose. Relaxation in Magnetic Particle Imaging.

Degree: Bioengineering, 2013, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/4tm8n7kh

► Magnetic particle imaging (MPI) is a novel medical imaging modality that spatially detects a tracer of superparamagnetic iron oxide nanoparticles (SPIOs) with high sensitivity, contrast,… (more)

▼ Magnetic particle imaging (MPI) is a novel medical imaging modality that spatially detects a tracer of superparamagnetic iron oxide nanoparticles (SPIOs) with high sensitivity, contrast, and no tissue penetration limitations. MPI has great potential for safer angiography, in vivo cell tracking, and cancer detection, among other applications. Current MPI theoretical descriptions and reconstruction techniques make an adiabatic assumption that the SPIO tracer instantaneously follows the applied magnetic fields of the MPI scanner. This assumption is not strictly true, and we refer to SPIO magnetization delays as relaxation effects.We begin by extending the x-space theory of MPI to include relaxation effects. We choose this MPI theory because it directly converts the temporal MPI signal to the image (spatial) domain, lending itself well to investigating how relaxation time delays translate into spatial effects. Using the non-adiabatic x-space theory and experimentally-measured data, we demonstrate that relaxation blurs the x-space image in the scanning direction. Next, we study how we may design MPI scanning sequences to minimize relaxation-induced blurring. From the non-adiabatic x-space theory we derive a mathematical description of how this blur can vary with scanning parameters for a given relaxation time. We compare theoretical predictions to experimental data by measuring relaxation times and spatial resolution under various scanning conditions. Despite increased relaxation time delays with slower scanning conditions, we observe that relaxation-induced blurring can be minimized when scanning slower. Finally, we derive a magnetic field-driven relaxation mechanism called magneto-viscous relaxation. This mechanism describes how the applied magnetic field creates a magnetic torque on the SPIO, inducing physical rotation of the SPIO to align with the field; however viscous resistance of the carrier liquid hinders this movement. We compare predicted relaxation times to measured values for a range of SPIO characteristics and scanning conditions. In this dissertation, we show how relaxation can have deleterious effects on the MPI signal and image. We explore how relaxation-induced blurring and relaxation times may be minimized through improved SPIO characteristics and MPI scanning sequence design. In addition to improving MPI image quality, this important area of research can lead to future clinical applications. Using this knowledge and specially-designed MPI pulse sequences, we can exploit variations in relaxation behavior as a source of contrast, which will increase the diagnostic potential of MPI.

Subjects/Keywords: Biomedical engineering; Medical imaging

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APA (6^th Edition):

Croft, L. R. (2013). Relaxation in Magnetic Particle Imaging. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/4tm8n7kh

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Croft, Laura Rose. “Relaxation in Magnetic Particle Imaging.” 2013. Thesis, University of California – Berkeley. Accessed January 24, 2021. http://www.escholarship.org/uc/item/4tm8n7kh.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Croft, Laura Rose. “Relaxation in Magnetic Particle Imaging.” 2013. Web. 24 Jan 2021.

Vancouver:

Croft LR. Relaxation in Magnetic Particle Imaging. [Internet] [Thesis]. University of California – Berkeley; 2013. [cited 2021 Jan 24]. Available from: http://www.escholarship.org/uc/item/4tm8n7kh.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Croft LR. Relaxation in Magnetic Particle Imaging. [Thesis]. University of California – Berkeley; 2013. Available from: http://www.escholarship.org/uc/item/4tm8n7kh

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Cornell University

27. Horton, Nicholas. Three-Photon Microscopy At 1700 Nm For In Vivo Imaging.

Degree: PhD, Applied Physics, 2015, Cornell University

URL: http://hdl.handle.net/1813/40694

► Multiphoton fluorescence microscopy (MPM) allows scientists to noninvasively observe structures deep within tissue. Two-photon microscopy (2PM) in the 750-1000 nm excitation region has been the… (more)

▼ Multiphoton fluorescence microscopy (MPM) allows scientists to noninvasively observe structures deep within tissue. Two-photon microscopy (2PM) in the 750-1000 nm excitation region has been the standard MPM technique since its first demonstration in 1990. However, the maximum imaging depth for 2PM is limited by the signal-to-background ratio (SBR). In this dissertation, three-photon imaging at 1700 nm excitation wavelength (1700 nm 3PM) is presented. The combination of the long excitation wavelength and the higher order nonlinear excitation overcomes the SBR limitations of 2PM, enabling biological investigations to take place at greater depth within tissue. In chapter 1, tissue imaging is discussed, paying special attention to the development of laser scanning fluorescence microscopy. In chapter 2, non-invasive, high resolution, in vivo imaging of subcortical structures within an intact mouse brain using 1700 nm 3PM is presented. Vascular structures as well as red fluorescent protein (RFP)-labeled neurons within the mouse hippocampus are imaged. In chapter 3, dispersion compensation of 1700 nm 3PM is discussed. Signal generation in 3PM is proportional to the inverse-squared of the pulse width. We show that the high normal dispersion of a silicon wafer can be conveniently used to compensate the anomalous dispersion of a 1,700 nm excitation three-photon microscope. We achieved over a factor of two reduction in pulse width at the sample, which corresponded to over a 4x increase in the three-photon signal. This signal increase was demonstrated within the mouse brain in vivo. In chapter 4, through-skull imaging using 1700 nm 3PM is demonstrated. The strong scattering properties of the skull traditionally require either its partial or total removal in order to achieve a sufficient penetration depth. Skull modifications have been shown to alter brain properties, which can subsequently affect imaging experiments. We demonstrate in vivo vascular imaging 720 m below the skull-brain interface through an unthinned, intact mouse skull and RFP-labeled neuron imaging 350 m below the skull-brain interface. Our results show that long-wavelength 3PM has the potential to perform high spatial resolution in vivo imaging deep in the mouse brain without the removal of the skull. Advisors/Committee Members: Xu,Chunhui (chair), Schaffer,Chris (committee member), Harris-Warrick,Ronald Morgan (committee member).

Subjects/Keywords: Multiphoton Microscopy; Biomedical Imaging; Optics

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APA (6^th Edition):

Horton, N. (2015). Three-Photon Microscopy At 1700 Nm For In Vivo Imaging. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/40694

Chicago Manual of Style (16^th Edition):

Horton, Nicholas. “Three-Photon Microscopy At 1700 Nm For In Vivo Imaging.” 2015. Doctoral Dissertation, Cornell University. Accessed January 24, 2021. http://hdl.handle.net/1813/40694.

MLA Handbook (7^th Edition):

Horton, Nicholas. “Three-Photon Microscopy At 1700 Nm For In Vivo Imaging.” 2015. Web. 24 Jan 2021.

Vancouver:

Horton N. Three-Photon Microscopy At 1700 Nm For In Vivo Imaging. [Internet] [Doctoral dissertation]. Cornell University; 2015. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1813/40694.

Council of Science Editors:

Horton N. Three-Photon Microscopy At 1700 Nm For In Vivo Imaging. [Doctoral Dissertation]. Cornell University; 2015. Available from: http://hdl.handle.net/1813/40694

Purdue University

28. Shen, Litao. Diffusion tensor imaging application.

Degree: 2015, Purdue University

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=1602902

► Central nervous system (CNS) related conditions and diseases like mild traumatic brain injury (mTBI) and multiple sclerosis (MS) affect people’s life quality, yet there… (more)

▼ Central nervous system (CNS) related conditions and diseases like mild traumatic brain injury (mTBI) and multiple sclerosis (MS) affect people’s life quality, yet there is no single test for the diagnosis of these diseases or conditions. Patients may need to wait for years until they are diagnosed correctly to get the correct treatment, which is often too late. Thus, there is a strong need to develop some techniques to aid the diagnosis of CNS-related conditions and diseases. The conventional MRI can reveal the structure of the brain but cannot detect the difference between the healthy tissue and the anomalies. Diffusion tensor imaging (DTI) has been used for detecting white matter integrity and demyelination for the past decade in experiments and has been proven to have the ability to depict the problem effectively. In the past decade, many techniques were found based on DTI data, and these techniques improved pre-processing, processing, and post-processing. Though there are many software and APIs that can provide functions for DTI file input/output (IO), visualization and other DTI related topics, there is no general software or API that is dedicated to covering the whole processing procedure of DTI that at the same time can be extended easily by the user. This thesis is dedicated to developing a software that can be used to aid in the diagnosis of CNS-related conditions and diseases while at the same time trying to cover as many topics as possible. Another purpose is to make the software highly extensible. This thesis work first introduces the background of CNS-related disease and uses MS as an example to introduce the process of demyelination and the white matter integrity problem, which are involved in these CNS-related diseases and conditions. Then the diffusion process and the technique that can detect the diffusion signal (DTI) is presented. After this, concepts and meaning of the secondary metrics are discussed. Then, current existing software and APIs and their advantages and disadvantages are outlined. After these points, the techniques that are discussed in this thesis as well as their advantages are outlined. This part is followed by the charts and code samples which can illustrate the process and structure of this software. Then different modules and their results are explained. In this software, the results are represented by images and 3D models. There are color images, pseudo color images with different schemes and gray scale images. Images are mainly included to represent the FA and MD data. In this software, streamlines are generated from the eigenvalue and eigenvector. Then a bundled result for the streamline is also realized in this software. The streamline and bundled results are 3D models. For 3D models, there are mainly two ways to display the real 3D model. One is the naked eye 3D which doesn’t require the user to wear glasses but has less stereoscopic characteristics. As the stereoscopic monitors and glasses are more and more popular and…

Subjects/Keywords: Biomedical engineering; Medical imaging

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APA (6^th Edition):

Shen, L. (2015). Diffusion tensor imaging application. (Thesis). Purdue University. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=1602902

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shen, Litao. “Diffusion tensor imaging application.” 2015. Thesis, Purdue University. Accessed January 24, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=1602902.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shen, Litao. “Diffusion tensor imaging application.” 2015. Web. 24 Jan 2021.

Vancouver:

Shen L. Diffusion tensor imaging application. [Internet] [Thesis]. Purdue University; 2015. [cited 2021 Jan 24]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=1602902.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shen L. Diffusion tensor imaging application. [Thesis]. Purdue University; 2015. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=1602902

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Gordon, Andrew Christian. Tuning Your RADIOembolization| Imaging-guidance of Yttrium-90 Radioembolization.

Degree: 2016, Northwestern University

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10160495

► Hepatocellular carcinoma (HCC) is the second leading cause of cancer death in the world and the liver is a common site of metastases from… (more)

Subjects/Keywords: Biomedical engineering; Medical imaging; Oncology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gordon, A. C. (2016). Tuning Your RADIOembolization| Imaging-guidance of Yttrium-90 Radioembolization. (Thesis). Northwestern University. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10160495

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gordon, Andrew Christian. “Tuning Your RADIOembolization| Imaging-guidance of Yttrium-90 Radioembolization.” 2016. Thesis, Northwestern University. Accessed January 24, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=10160495.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gordon, Andrew Christian. “Tuning Your RADIOembolization| Imaging-guidance of Yttrium-90 Radioembolization.” 2016. Web. 24 Jan 2021.

Vancouver:

Gordon AC. Tuning Your RADIOembolization| Imaging-guidance of Yttrium-90 Radioembolization. [Internet] [Thesis]. Northwestern University; 2016. [cited 2021 Jan 24]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10160495.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gordon AC. Tuning Your RADIOembolization| Imaging-guidance of Yttrium-90 Radioembolization. [Thesis]. Northwestern University; 2016. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10160495

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

30. Atchia, Yaaseen. Optical Neural Imaging in Rodents using VCSELs.

Degree: 2013, University of Toronto

URL: http://hdl.handle.net/1807/42673

►

Optical brain imaging is proven to be useful to understand brain function and morphology at cellular and network level. Different optical imaging modalities were developed… (more)

Subjects/Keywords: Biomedical Imaging; VCSEL; 0544; 0541

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Atchia, Y. (2013). Optical Neural Imaging in Rodents using VCSELs. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/42673

Chicago Manual of Style (16^th Edition):

Atchia, Yaaseen. “Optical Neural Imaging in Rodents using VCSELs.” 2013. Masters Thesis, University of Toronto. Accessed January 24, 2021. http://hdl.handle.net/1807/42673.

MLA Handbook (7^th Edition):

Atchia, Yaaseen. “Optical Neural Imaging in Rodents using VCSELs.” 2013. Web. 24 Jan 2021.

Vancouver:

Atchia Y. Optical Neural Imaging in Rodents using VCSELs. [Internet] [Masters thesis]. University of Toronto; 2013. [cited 2021 Jan 24]. Available from: http://hdl.handle.net/1807/42673.

Council of Science Editors:

Atchia Y. Optical Neural Imaging in Rodents using VCSELs. [Masters Thesis]. University of Toronto; 2013. Available from: http://hdl.handle.net/1807/42673

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Open Access Theses and Dissertations