subject:(Bioluminescence)

Oregon State University

1. Esaias, Wayne E. Ecological significance of dinoflagellate bioluminescence.

Degree: MS, Oceanography, 1969, Oregon State University

URL: http://hdl.handle.net/1957/28915

► The nature of the bioluminescence of Gonyaulax catenella is similar to that observed for other dinoflagellates in culture, showing photoperiod-entrained rhythms of luminescence and stimulability… (more)

Subjects/Keywords: Bioluminescence

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APA (6^th Edition):

Esaias, W. E. (1969). Ecological significance of dinoflagellate bioluminescence. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/28915

Chicago Manual of Style (16^th Edition):

Esaias, Wayne E. “Ecological significance of dinoflagellate bioluminescence.” 1969. Masters Thesis, Oregon State University. Accessed February 28, 2021. http://hdl.handle.net/1957/28915.

MLA Handbook (7^th Edition):

Esaias, Wayne E. “Ecological significance of dinoflagellate bioluminescence.” 1969. Web. 28 Feb 2021.

Vancouver:

Esaias WE. Ecological significance of dinoflagellate bioluminescence. [Internet] [Masters thesis]. Oregon State University; 1969. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1957/28915.

Council of Science Editors:

Esaias WE. Ecological significance of dinoflagellate bioluminescence. [Masters Thesis]. Oregon State University; 1969. Available from: http://hdl.handle.net/1957/28915

Oregon State University

2. Esaias, Wayne E. Studies on the occurrence, physiology, and ecology of bioluminescence in dinoflagellates.

Degree: PhD, Oceanography, 1972, Oregon State University

URL: http://hdl.handle.net/1957/28368

► To provide further information on the occurrence and geographical variations of bioluminescent capabilities of marine dinoflagellates, forty species, representing twelve genera, of dinoflagellates from Yaquina… (more)

▼ To provide further information on the occurrence and geographical variations of bioluminescent capabilities of marine dinoflagellates, forty species, representing twelve genera, of dinoflagellates from Yaquina Bay, Oregon, were examined for bioluminescence as single cell isolates. Seventeen species from the genera Ceratium (1 sp.), Gonyaulax (3 sp.), and Peridinium (13 sp.) were found to be bioluminescent. Ceratium fusus was the only member of the genus found to emit light; G. triacantha was found to be non-bioluminescent. The total photon emission of each luminescent species is reported. Values ranged from 1.05 x 10¹⁰ photons per P. depressum to 2.1 x 1O⁷ photons per G. digitale. As a taxon, the genus Peridinium emitted more light by an order of magnitude than did Ceratium or Gonyaulax. Comparisons with previous reports are made. Photoinhibition of the mechanical receptor mechanism is largely responsible for orders of magnitude diel variations of stimulable bioluminescence in the auxotrophic dinoflagellates. The mechanically stimulable bioluminescence of members of the Gonyaulax catenella group can be photoinhibited completely by exposure to as little as 10¹³ quanta/cm² delivered as a pulse of width between 0.1 and 10 seconds. There is an initial time lag of one minute, followed by a first order decay to approximately one percent of the bioluminescence of unexposed controls. The half time of this decay is only 50 seconds. Action spectra for photoinhibition in Gonyaulax catenella, G. acatenlla, and G. tamarensis revealed a single absorption band with a maximum at 562 nm. Photoinhibition appears to raise the threshold of sensitivity of the shear receptor mechanism. Chemically stimulable bioluminescence is unaffected by these brief exposures to light. Grazing experiments were conducted with three calanoid copepods and three species of bioluminescent dinoflagellates, using procedures which yielded samples of cultures with high and low capacities for mechanically stimulable bioluminescence. In all cases the ingestion rates were lower for the high bioluminescent capacity samples than for the samples having a reduced bioluminescent capacity. These results indicate that dinoflagellate bioluminescence has survival value as a defense against copepod grazing. Of several possible mechanisms, we propose that the flash is a visual, protean display which startles or confuses the copepod sufficiently to allow the dinoflagellate to escape. The net evolutionary value is that predation would be reduced on a dinoflagellate population as a whole. Advisors/Committee Members: Curl, Herbert C. Jr (advisor).

Subjects/Keywords: Bioluminescence

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APA (6^th Edition):

Esaias, W. E. (1972). Studies on the occurrence, physiology, and ecology of bioluminescence in dinoflagellates. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/28368

Chicago Manual of Style (16^th Edition):

Esaias, Wayne E. “Studies on the occurrence, physiology, and ecology of bioluminescence in dinoflagellates.” 1972. Doctoral Dissertation, Oregon State University. Accessed February 28, 2021. http://hdl.handle.net/1957/28368.

MLA Handbook (7^th Edition):

Esaias, Wayne E. “Studies on the occurrence, physiology, and ecology of bioluminescence in dinoflagellates.” 1972. Web. 28 Feb 2021.

Vancouver:

Esaias WE. Studies on the occurrence, physiology, and ecology of bioluminescence in dinoflagellates. [Internet] [Doctoral dissertation]. Oregon State University; 1972. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1957/28368.

Council of Science Editors:

Esaias WE. Studies on the occurrence, physiology, and ecology of bioluminescence in dinoflagellates. [Doctoral Dissertation]. Oregon State University; 1972. Available from: http://hdl.handle.net/1957/28368

Georgia Tech

3. Tung, Jack. Development and application of inhibitory luminopsins for the treatment of epilepsy.

Degree: PhD, Biomedical Engineering (Joint GT/Emory Department), 2016, Georgia Tech

URL: http://hdl.handle.net/1853/58155

► Optogenetics has shown great promise as a direct neuromodulatory tool for halting seizure activity in various animal models of epilepsy. However, light delivery into the… (more)

▼ Optogenetics has shown great promise as a direct neuromodulatory tool for halting seizure activity in various animal models of epilepsy. However, light delivery into the brain is still a major practical challenge that needs to be addressed before future clinical translation is feasible. Not only does light delivery into the brain require surgically implanted hardware that can be both invasive and restrictive, but it is also difficult to illuminate large or complicated structures in the brain due to light scatter and attenuation. We have bypassed the challenges of external light delivery by directly coupling a bioluminescent light source (a genetically encoded Renilla luciferase) to an inhibitory opsin (Natronomonas halorhodopsin) as a single fusion protein, which we term an inhibitory luminopsin (iLMO). iLMOs were developed and characterized in vitro and in vivo using intracellular recordings, multielectrode arrays, and behavioral testing. iLMO2 was shown to generate hyperpolarizing outward currents in response to both external light and luciferase substrate, which was sufficient to suppress action potential firing and synchronous bursting activity in vitro. iLMO2 was further shown to suppress single-unit firing rate and local field potentials in the hippocampus of anesthetized and awake animals. Finally, expression of iLMO was scaled up to multiple structures of the basal ganglia to modulate rotational behavior of freely moving animals in a hardware-independent fashion. iLMO2 was further utilized to acutely suppress focal epileptic discharges induced by intracerebral injection of bicuculline and generalized seizures resulting from systemic administration of pentylenetetrazol. Inhibitory luminopsins have enabled the possibility of optogenetic inhibition of neural activity in a non-invasive and hardware-independent fashion. This work increases the versatility, scalability, and practicality of utilizing optogenetic approaches for halting seizure activity in vivo. Advisors/Committee Members: Gross, Robert E. (advisor), Boulis, Nicholas (committee member), Hochman, Shawn (committee member), Hochgeschwender, Ute (committee member), Yu, Shan Ping (committee member).

Subjects/Keywords: Optogenetics; Bioluminescence; Luminopsin

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APA (6^th Edition):

Tung, J. (2016). Development and application of inhibitory luminopsins for the treatment of epilepsy. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/58155

Chicago Manual of Style (16^th Edition):

Tung, Jack. “Development and application of inhibitory luminopsins for the treatment of epilepsy.” 2016. Doctoral Dissertation, Georgia Tech. Accessed February 28, 2021. http://hdl.handle.net/1853/58155.

MLA Handbook (7^th Edition):

Tung, Jack. “Development and application of inhibitory luminopsins for the treatment of epilepsy.” 2016. Web. 28 Feb 2021.

Vancouver:

Tung J. Development and application of inhibitory luminopsins for the treatment of epilepsy. [Internet] [Doctoral dissertation]. Georgia Tech; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1853/58155.

Council of Science Editors:

Tung J. Development and application of inhibitory luminopsins for the treatment of epilepsy. [Doctoral Dissertation]. Georgia Tech; 2016. Available from: http://hdl.handle.net/1853/58155

4. Colepicolo, Pio. Contribuição ao estudo de espécies brasileiras de elaterídeos luminescentes: bioluminescência, metabolismo radicalar de oxigênio e digestão extra-corpórea.

Degree: PhD, Bioquímica, 1986, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-25092014-150325/ ;

►

Esta tese contem dados biológicos, ecológicos e bioquímicos de quatorze espécies brasileiras de elaterídeos luminescentes, distribuídos em duas tribos. Os insetos foram coletados de vários… (more)

▼

Esta tese contem dados biológicos, ecológicos e bioquímicos de quatorze espécies brasileiras de elaterídeos luminescentes, distribuídos em duas tribos. Os insetos foram coletados de vários habitats e criados em laboratório, em colaboração com pesquisadores do Museu de Zoologia da USP. Demonstramos inicialmente que todos os elaterídeos estudados contêm a mesma luciferina de lampirideos, independentemente da natureza da lanterna (toráxica ou abdominal) e do estágio metamórfico. Estudos da biossíntese da luciferina a partir de 14C-cistina mostraram um rendimento radioquímico de síntese da ordem de 4%. Verificamos que cada espécie tem um λmax de bioluminescência característico, o que pode ter importância taxonômica, especialmente no caso de larvas. Estudo físico-químico (ïn vitro\") da luciferase mostrou a possível existência de isozimas de luciferase nas fases da metamorfose e nas lanternas abdominal e toráxica. A intensidade de emissão por ovos e larvas aumenta logarítmicamente com o aumento da temperatura absoluta, o que deve ter importância no mecanismo de caça das larvas. Ênfase especial foi dada ao Pyrearinus termitilluminans, espécie inquilina dos conhecidos \"cupinzeiros luminescentesëncontrados no cerrado do Brasil Central e na bacia amazônica; descreve-se o processo de infestação dos cupinzeiros, usando-se observações de campo e moldagens das galerias com poliestireno. Uma conexão interessante foi constatada entre a bioluminescência e a produção de radicais de oxigênio, acompanhada por medidas de níveis de superóxido dismutase (SOD), ao comparar-se elaterídeos luminescentes e não-luminescentes da mesma tribo e ao comparar-se os segmentos abdominais e toráxicos de larvas de Pyrearinus termitilluminans. É também interessante notar que larvas de elaterídeos habitantes de troncos em apodrecimento (onde a concentração do oxigênio < 2%) possuem menor atividade da enzima antioxidante SOD que larvas de Pyrearinus termitilluminans, encontradas nas galerias aeradas dos cupinzeiros. Discute-se possíveis mecanismos de estocagem de oxigênio nas larvas luminescentes. Finalmente descobrimos que o regurgitado injetado pelas larvas de elaterídeos nas suas presas é fortemente tamponado em pH 7,3 e contém urna mistura de proteinases (tripsina e aminopeptidase) e carbohidrases (amilase, celulase, celobiase, maltase e trealase). A injeção deste coquetel enzimático imobiliza a presa e executa digestão pré-oral. As enzimas citadas foram caracterizadas por parâmetros físico-químicos (atividade específica, pH ótimo, pI, Mw, Km e migração eletroforética relativa) e mapeadas no interior do tubo digestivo das larvas. Os dados enzimaticos são tentativamente utilizados para análise filogenética destes insetos.

This thesis contains biological, ecological and biochemical data of fourteen species of Brazilian luminescent Elateridae (two tribes, four genera). The insects were collected in different habitats and reared from eggs in laboratory at the Museu de Zoologia da Universidade de São Paulo. Thin layer chromatography…

Advisors/Committee Members: Bechara, Etelvino Jose Henriques.

Subjects/Keywords: Bioluminescence; Bioluminescência

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APA (6^th Edition):

Colepicolo, P. (1986). Contribuição ao estudo de espécies brasileiras de elaterídeos luminescentes: bioluminescência, metabolismo radicalar de oxigênio e digestão extra-corpórea. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/46/46131/tde-25092014-150325/ ;

Chicago Manual of Style (16^th Edition):

Colepicolo, Pio. “Contribuição ao estudo de espécies brasileiras de elaterídeos luminescentes: bioluminescência, metabolismo radicalar de oxigênio e digestão extra-corpórea.” 1986. Doctoral Dissertation, University of São Paulo. Accessed February 28, 2021. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-25092014-150325/ ;.

MLA Handbook (7^th Edition):

Colepicolo, Pio. “Contribuição ao estudo de espécies brasileiras de elaterídeos luminescentes: bioluminescência, metabolismo radicalar de oxigênio e digestão extra-corpórea.” 1986. Web. 28 Feb 2021.

Vancouver:

Colepicolo P. Contribuição ao estudo de espécies brasileiras de elaterídeos luminescentes: bioluminescência, metabolismo radicalar de oxigênio e digestão extra-corpórea. [Internet] [Doctoral dissertation]. University of São Paulo; 1986. [cited 2021 Feb 28]. Available from: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-25092014-150325/ ;.

Council of Science Editors:

Colepicolo P. Contribuição ao estudo de espécies brasileiras de elaterídeos luminescentes: bioluminescência, metabolismo radicalar de oxigênio e digestão extra-corpórea. [Doctoral Dissertation]. University of São Paulo; 1986. Available from: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-25092014-150325/ ;

Oregon State University

5. Uesugi, Sandra L. Evaluation of bioluminescence as a measure of bacterial cell density in porous media.

Degree: MS, Bioresource Engineering, 2000, Oregon State University

URL: http://hdl.handle.net/1957/32755

Subjects/Keywords: Bioluminescence – Evaluation

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APA (6^th Edition):

Uesugi, S. L. (2000). Evaluation of bioluminescence as a measure of bacterial cell density in porous media. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/32755

Chicago Manual of Style (16^th Edition):

Uesugi, Sandra L. “Evaluation of bioluminescence as a measure of bacterial cell density in porous media.” 2000. Masters Thesis, Oregon State University. Accessed February 28, 2021. http://hdl.handle.net/1957/32755.

MLA Handbook (7^th Edition):

Uesugi, Sandra L. “Evaluation of bioluminescence as a measure of bacterial cell density in porous media.” 2000. Web. 28 Feb 2021.

Vancouver:

Uesugi SL. Evaluation of bioluminescence as a measure of bacterial cell density in porous media. [Internet] [Masters thesis]. Oregon State University; 2000. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1957/32755.

Council of Science Editors:

Uesugi SL. Evaluation of bioluminescence as a measure of bacterial cell density in porous media. [Masters Thesis]. Oregon State University; 2000. Available from: http://hdl.handle.net/1957/32755

University of Illinois – Chicago

6. Lee, Hyunjin. Development of Probes for Bile Acid Transporters and Synthetic Approaches to the Core of Massadine.

Degree: 2018, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/23256

► My graduate work comprises two components: 1) The development of novel probes to study the activities of bile acid (BA) by exploiting a self-cleavable disulfide… (more)

Subjects/Keywords: Synthesis; Bioluminescence; Organic Chemistry

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APA (6^th Edition):

Lee, H. (2018). Development of Probes for Bile Acid Transporters and Synthetic Approaches to the Core of Massadine. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/23256

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lee, Hyunjin. “Development of Probes for Bile Acid Transporters and Synthetic Approaches to the Core of Massadine.” 2018. Thesis, University of Illinois – Chicago. Accessed February 28, 2021. http://hdl.handle.net/10027/23256.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lee, Hyunjin. “Development of Probes for Bile Acid Transporters and Synthetic Approaches to the Core of Massadine.” 2018. Web. 28 Feb 2021.

Vancouver:

Lee H. Development of Probes for Bile Acid Transporters and Synthetic Approaches to the Core of Massadine. [Internet] [Thesis]. University of Illinois – Chicago; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10027/23256.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lee H. Development of Probes for Bile Acid Transporters and Synthetic Approaches to the Core of Massadine. [Thesis]. University of Illinois – Chicago; 2018. Available from: http://hdl.handle.net/10027/23256

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Irvine

7. Zhang, Brendan Shin-kuei. Expanding the bioluminescent tool box for multicomponent imaging.

Degree: Chemistry, 2018, University of California – Irvine

URL: http://www.escholarship.org/uc/item/3f09r9dq

► Optical reporters have revolutionized our ability to visualize biological mechanisms in action. Among the most popular techniques for imaging in whole tissues and living organisms… (more)

▼ Optical reporters have revolutionized our ability to visualize biological mechanisms in action. Among the most popular techniques for imaging in whole tissues and living organisms is bioluminescence. One of the most widely used bioluminescent systems comprises firefly luciferase (Fluc) and the small molecule D-luciferin. These components produce photons that can be detected with sensitive cameras. Since mammalian tissues produce little to no photons endogenously, bioluminescence is well suited for imaging in whole organisms. Consequently, Fluc and D-luciferin have been widely used to track cell movements, gene expression patterns and other activities in a variety of preclinical models. Bioluminescence has been largely limited to imaging one cell type at a time, though, due to a lack of distinguishable luciferase-luciferin pairs. To address this void, my thesis work focused on developing spectrally resolved for multicomponent imaging. I generated both electronically modified luciferins and mutant luciferases. Isomeric luciferin analogs bearing a pyridone moiety were designed and synthesized. These analogs exhibited distinct bioluminescence spectra that could be distinguished using optical filters. However, the analogs were weak emitters compared to the native substrate. Mutant luciferases with improved photon outputs were identified via library screening and directed evolution. Significant improvements in luciferase activity could be achieved in only 1-2 rounds of screening. While spectrally resolved probes can be readily distinguished in transparent media, discriminating wavelengths through thick tissues is challenging. To address this issue, I developed a mutually orthogonal luciferase-luciferin pair. Pi-extended luciferin analogs were synthesized, and a complementary luciferase was engineered using computational enzyme design. This custom luciferase-luciferin pair was compatible with three existing bioluminescent tools, enabling selective imaging of four luciferases based on substrate preference. Finally, I expressed and purified orthogonal luciferases for X-ray crystallography. Luciferase purity and fidelity were verified using a variety of analytical techniques. However, when the luciferases were subjected to published crystallization procedures, only protein precipitation was observed. Ligands were shown to stabilize the enzyme, and crystallization attempts with these molecules yielded several promising “hits”. Collectively, my thesis work expands the toolset for multicomponent imaging and builds towards an understanding of luciferase substrate specificity.

Subjects/Keywords: Chemistry; bioluminescence; imaging; luciferase; luciferin

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APA (6^th Edition):

Zhang, B. S. (2018). Expanding the bioluminescent tool box for multicomponent imaging. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/3f09r9dq

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhang, Brendan Shin-kuei. “Expanding the bioluminescent tool box for multicomponent imaging.” 2018. Thesis, University of California – Irvine. Accessed February 28, 2021. http://www.escholarship.org/uc/item/3f09r9dq.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhang, Brendan Shin-kuei. “Expanding the bioluminescent tool box for multicomponent imaging.” 2018. Web. 28 Feb 2021.

Vancouver:

Zhang BS. Expanding the bioluminescent tool box for multicomponent imaging. [Internet] [Thesis]. University of California – Irvine; 2018. [cited 2021 Feb 28]. Available from: http://www.escholarship.org/uc/item/3f09r9dq.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhang BS. Expanding the bioluminescent tool box for multicomponent imaging. [Thesis]. University of California – Irvine; 2018. Available from: http://www.escholarship.org/uc/item/3f09r9dq

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

8. Yu, Yee Yung. Molecular design and synthesis of AIEgens with long emission wavelength for biological applications.

Degree: 2016, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-87121 ; https://doi.org/10.14711/thesis-b1626212 ; http://repository.ust.hk/ir/bitstream/1783.1-87121/1/th_redirect.html

► Light is of essential importance to the humankind. It is one the most fundamental and indispensable elements to our life and society. Research on fluorescent… (more)

▼ Light is of essential importance to the humankind. It is one the most fundamental and indispensable elements to our life and society. Research on fluorescent materials remains a principal focus and hot topic in the scientific community because of their vast potential applications. Numerous fluorophores have been prepared and found to be highly emissive in their dilute solutions. However, for most practical applications, they are used as solid films and aggregates. Unfortunately, the emission of many conventional fluorophores is partially or completely quenched upon aggregate formation. Such a phenomenon of aggregation-caused quenching (ACQ) has been documented for more than half a century since Förster’s discovery in 1954. Although ACQ fluorophores have found many useful applications, realization of their full potential has become impossible. In our search for efficient luminescent materials, we observed a phenomenon of aggregation-induced emission (AIE) in a group of propeller-shaped molecules such as siloles and tetraphenylethene. These AIE luminogens (AIEgens) show weak or no fluorescence in the solution state but emit efficiently when aggregated. Through systematic studies and mechanistic analyses on these molecular rotors, we have deduced the restriction of intramolecular motion (RIM) is the main cause for their AIE effect. Since the observation of the AIE phenomenon in 2001, excellent work has been done to uncover its underlying mechanism and realize its practical uses. However, much remains to be explored in this young research area. The AIE effect can be utilized in many applications wherever RIM process is activated, with possibilities limited by only our imagination. Our group has reported many different applications like optic devices, chemosensors, bioprobes, bio-imaging and etc. AIEgens always enjoyed highly brightness, specificity, biocompatibility and photostability. Although AIEgens demonstrated many advantages in bio-applications, AIEgens with long-wavelength absorption and emission were still rarely reported. In this research project, we have designed different red-emissive AIEgens and utilized their potential in bio-applications. In Chapter II to IV, we developed a dual-targeting AIEgen to nucleolus and mitochondria, and two plasma-membrane-targeting AIEgens for monitoring morphology changes of the membrane and generating ROS for PDT respectively. Another AIEgen was able to generate ROS for increasing radiosensitivity of cancer cells in radiotherapy (Chapter V) and a water-soluble AIEgen was functionalized for antibody labelling through receptor-mediated endocytosis (Chapter VI). In Chapter VII, a photoactivatable AIEgen was demonstrated as a model for super-resolution imaging.

Subjects/Keywords: Bioluminescence ; Aggregation (Chemistry) ; Photoemission

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APA (6^th Edition):

Yu, Y. Y. (2016). Molecular design and synthesis of AIEgens with long emission wavelength for biological applications. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-87121 ; https://doi.org/10.14711/thesis-b1626212 ; http://repository.ust.hk/ir/bitstream/1783.1-87121/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yu, Yee Yung. “Molecular design and synthesis of AIEgens with long emission wavelength for biological applications.” 2016. Thesis, Hong Kong University of Science and Technology. Accessed February 28, 2021. http://repository.ust.hk/ir/Record/1783.1-87121 ; https://doi.org/10.14711/thesis-b1626212 ; http://repository.ust.hk/ir/bitstream/1783.1-87121/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yu, Yee Yung. “Molecular design and synthesis of AIEgens with long emission wavelength for biological applications.” 2016. Web. 28 Feb 2021.

Vancouver:

Yu YY. Molecular design and synthesis of AIEgens with long emission wavelength for biological applications. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2016. [cited 2021 Feb 28]. Available from: http://repository.ust.hk/ir/Record/1783.1-87121 ; https://doi.org/10.14711/thesis-b1626212 ; http://repository.ust.hk/ir/bitstream/1783.1-87121/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yu YY. Molecular design and synthesis of AIEgens with long emission wavelength for biological applications. [Thesis]. Hong Kong University of Science and Technology; 2016. Available from: http://repository.ust.hk/ir/Record/1783.1-87121 ; https://doi.org/10.14711/thesis-b1626212 ; http://repository.ust.hk/ir/bitstream/1783.1-87121/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University College Cork

9. Morrissey, Ruth M. Shining light on food microbiology; applications of luciferase-tagged microorganisms in the food industry.

Degree: 2013, University College Cork

URL: http://hdl.handle.net/10468/1395

► Bioluminescence is the production of light by living organisms as a result of a number of enzyme catalysed reactions caused by enzymes termed luciferases. The… (more)

Subjects/Keywords: Luciferase; Luciferases; Bioluminescence; Food – Microbiology

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APA (6^th Edition):

Morrissey, R. M. (2013). Shining light on food microbiology; applications of luciferase-tagged microorganisms in the food industry. (Thesis). University College Cork. Retrieved from http://hdl.handle.net/10468/1395

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Morrissey, Ruth M. “Shining light on food microbiology; applications of luciferase-tagged microorganisms in the food industry.” 2013. Thesis, University College Cork. Accessed February 28, 2021. http://hdl.handle.net/10468/1395.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Morrissey, Ruth M. “Shining light on food microbiology; applications of luciferase-tagged microorganisms in the food industry.” 2013. Web. 28 Feb 2021.

Vancouver:

Morrissey RM. Shining light on food microbiology; applications of luciferase-tagged microorganisms in the food industry. [Internet] [Thesis]. University College Cork; 2013. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10468/1395.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Morrissey RM. Shining light on food microbiology; applications of luciferase-tagged microorganisms in the food industry. [Thesis]. University College Cork; 2013. Available from: http://hdl.handle.net/10468/1395

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

10. Dev Kumar, Govindaraj. Role of airborne soil particulate in transfer of Salmonella spp. to tomato blossoms and consequential fruit contamination.

Degree: PhD, Food Science and Technology, 2011, Virginia Tech

URL: http://hdl.handle.net/10919/40421

► Contaminated tomatoes have become a commonly implicated vehicle of Salmonella outbreaks. Exposure of tomatoes to pathogen could occur in the field. Blossom inoculation with Salmonella… (more)

▼ Contaminated tomatoes have become a commonly implicated vehicle of Salmonella outbreaks. Exposure of tomatoes to pathogen could occur in the field. Blossom inoculation with Salmonella can result in contaminated fruit but natural routes of blossom contamination are not well known. Salmonellae have been known to survive in agricultural soil. Since dispersal of soil particulate by wind is a common phenomenon, the potential of airborne soil particulate as a vehicle of Salmonella contamination in tomato blossoms was examined. It was determined that Salmonella enterica serotype Anatum, Baildon, Braenderup, Montevideo, Newport, Javiana had similar survival patterns in both soil and water. At the end of 40 days, populations of Salmonella in soil dropped by 2.59 log CFU/g and 5.11 log CFU/g when enumerated on Tryptic Soy Agar Yeast Extract (TSAYE) and xylose lysine Tergitol 4 (XLT4) agar respectively. Salmonella populations in water reduced by 2.55 log CFU/ml (TSAYE, enumeration) and 2.94 log CFU/ml (XLT4, enumeration). Blossom to fruit formation takes 20-30 days in tomatoes hence the introduction or presence of the pathogen in agricultural soil and water could increase risk of blossom contamination. Also, it was determined that all Salmonella serotypes tested were capable of biofilm production on glass coverslips and quartz particles. Biofilm based attachment of Salmonella to sand might aid in its dispersal. To visualize transfer of pathogen from soil particulate to blossom in real-time, bioluminescent S. Baildon, S. Braenderup, S. Newport, S. Javiana and S. Anatum were created.Heat shock procedure was developed to improve electrotransformation efficiency in Salmonella. Transformed strains were compared for bioluminescence production and plasmid stability. S. Newport had the best bioluminescence properties but no difference was observed between strains for plasmid stability. Imaging of soil particulate - S. Newport mixture inoculated blossoms, indicated that the event led to pathogen transfer to blossom. It was also determined that S. Newport â soil particulate contaminated blossoms developed into fruits that were positive for S. Newport. S. Newport presence in blossom, fruit surface and internal tissue indicates that contaminated soil particulate could serve as a vehicle of tomato contamination. Advisors/Committee Members: Williams, Robert C. (committeechair), Boyer, Renee R. (committee member), Eifert, Joseph D. (committee member), Sriranganathan, Nammalwar (committee member).

Subjects/Keywords: tomato; dust; soil; bioluminescence; Salmonella

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APA (6^th Edition):

Dev Kumar, G. (2011). Role of airborne soil particulate in transfer of Salmonella spp. to tomato blossoms and consequential fruit contamination. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/40421

Chicago Manual of Style (16^th Edition):

Dev Kumar, Govindaraj. “Role of airborne soil particulate in transfer of Salmonella spp. to tomato blossoms and consequential fruit contamination.” 2011. Doctoral Dissertation, Virginia Tech. Accessed February 28, 2021. http://hdl.handle.net/10919/40421.

MLA Handbook (7^th Edition):

Dev Kumar, Govindaraj. “Role of airborne soil particulate in transfer of Salmonella spp. to tomato blossoms and consequential fruit contamination.” 2011. Web. 28 Feb 2021.

Vancouver:

Dev Kumar G. Role of airborne soil particulate in transfer of Salmonella spp. to tomato blossoms and consequential fruit contamination. [Internet] [Doctoral dissertation]. Virginia Tech; 2011. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10919/40421.

Council of Science Editors:

Dev Kumar G. Role of airborne soil particulate in transfer of Salmonella spp. to tomato blossoms and consequential fruit contamination. [Doctoral Dissertation]. Virginia Tech; 2011. Available from: http://hdl.handle.net/10919/40421

Washington University in St. Louis

11. Flentie, Kelly. Real-Time Bioluminescence Imaging Of Salmonella-Neoplastic Cell Interactions.

Degree: PhD, Biology and Biomedical Sciences: Molecular Microbiology and Microbial Pathogenesis, 2011, Washington University in St. Louis

URL: https://openscholarship.wustl.edu/etd/575

► Salmonella Typhimurium is a Gram-negative bacterial pathogen and a common cause of gastroenteritis in humans. The organism utilizes a multitude of well-studied virulence factors to… (more)

▼ Salmonella Typhimurium is a Gram-negative bacterial pathogen and a common cause of gastroenteritis in humans. The organism utilizes a multitude of well-studied virulence factors to invade and replicate in host intestinal epithelial cells and macrophages. Interestingly, Salmonella is also capable of localizing to tumors in in vivo model systems, and while the typical route of Salmonella infection and pathogenesis has been thoroughly investigated, the behavior of Salmonella in the tumor microenvironment has not. Therefore, to investigate Salmonella and host behavior during bacterial-neoplastic cell interactions, I utilized two high-throughput screens. In the first, I designed a bioluminescent transposon-reporter trap to identify specific Salmonella genes activated in the context of cancer cell co-culture conditions. Through this work, I identified five Salmonella genes reproducibly activated by co-culture with cancer cells, and further isolated the activating stimulus to low pH. Because low pH is a common characteristic of the tumor microenvironment, I also demonstrated the pH inducibility and reversibility of Salmonellagene activation in tumors ex vivo and in vivo. In a separate study, to better understand how host neoplastic cells respond to Salmonella, I investigated the ability of Salmonellato induce pro-inflammatory responses in HCT116 colon carcinoma cells, specifically, NF-κB activation. Then, I performed a high-throughput siRNA screen to identify novel host kinases and phosphatases involved in detection of Salmonellaand activation of NF-κB signaling. For this work, I used a reporter construct consisting of an IκBα-firefly luciferase fusion protein transcriptionally activated by NF-κB. The reporter permitted imaging of both degradation of the NF-κB negative inhibitor IκBα and its resynthesis, which is dependent on NF-κB activation, following stimulus with Salmonella. The host kinase, NME3, was identified in the screen as a specific modulator of NF-κB. Knockdown of NME3 prevents proper activation of NF-κB signaling pathways in HCT116 cells exposed to Salmonella, demonstrating the role of this kinase as a positive regulator of NF-κB pro-inflammatory signaling in colon carcinoma cells. Advisors/Committee Members: David Piwnica-Worms.

Subjects/Keywords: Microbiology; Bioluminescence; Cancer; Salmonella

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APA (6^th Edition):

Flentie, K. (2011). Real-Time Bioluminescence Imaging Of Salmonella-Neoplastic Cell Interactions. (Doctoral Dissertation). Washington University in St. Louis. Retrieved from https://openscholarship.wustl.edu/etd/575

Chicago Manual of Style (16^th Edition):

Flentie, Kelly. “Real-Time Bioluminescence Imaging Of Salmonella-Neoplastic Cell Interactions.” 2011. Doctoral Dissertation, Washington University in St. Louis. Accessed February 28, 2021. https://openscholarship.wustl.edu/etd/575.

MLA Handbook (7^th Edition):

Flentie, Kelly. “Real-Time Bioluminescence Imaging Of Salmonella-Neoplastic Cell Interactions.” 2011. Web. 28 Feb 2021.

Vancouver:

Flentie K. Real-Time Bioluminescence Imaging Of Salmonella-Neoplastic Cell Interactions. [Internet] [Doctoral dissertation]. Washington University in St. Louis; 2011. [cited 2021 Feb 28]. Available from: https://openscholarship.wustl.edu/etd/575.

Council of Science Editors:

Flentie K. Real-Time Bioluminescence Imaging Of Salmonella-Neoplastic Cell Interactions. [Doctoral Dissertation]. Washington University in St. Louis; 2011. Available from: https://openscholarship.wustl.edu/etd/575

University of Arizona

12. Cicero, Joseph Michael. Evolution of the glow-signal system in Microphotus (Coleoptera, Lampyridae) .

Degree: 1981, University of Arizona

URL: http://hdl.handle.net/10150/557669

Subjects/Keywords: Fireflies.; Bioluminescence.

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APA (6^th Edition):

Cicero, J. M. (1981). Evolution of the glow-signal system in Microphotus (Coleoptera, Lampyridae) . (Masters Thesis). University of Arizona. Retrieved from http://hdl.handle.net/10150/557669

Chicago Manual of Style (16^th Edition):

Cicero, Joseph Michael. “Evolution of the glow-signal system in Microphotus (Coleoptera, Lampyridae) .” 1981. Masters Thesis, University of Arizona. Accessed February 28, 2021. http://hdl.handle.net/10150/557669.

MLA Handbook (7^th Edition):

Cicero, Joseph Michael. “Evolution of the glow-signal system in Microphotus (Coleoptera, Lampyridae) .” 1981. Web. 28 Feb 2021.

Vancouver:

Cicero JM. Evolution of the glow-signal system in Microphotus (Coleoptera, Lampyridae) . [Internet] [Masters thesis]. University of Arizona; 1981. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10150/557669.

Council of Science Editors:

Cicero JM. Evolution of the glow-signal system in Microphotus (Coleoptera, Lampyridae) . [Masters Thesis]. University of Arizona; 1981. Available from: http://hdl.handle.net/10150/557669

Louisiana State University

13. Pfeifer, Zachary. Bioluminescence.

Degree: MM, Music, 2010, Louisiana State University

URL: etd-04272010-231859 ; https://digitalcommons.lsu.edu/gradschool_theses/2293

► The ability of certain animals to create natural light is called bioluminescence. This ability is found throughout the world in various biomes but is most… (more)

▼ The ability of certain animals to create natural light is called bioluminescence. This ability is found throughout the world in various biomes but is most common in the deep ocean, in layers of dark water that remain untouched by the sun’s rays. One way Bioluminescence attempts to convey light moving though the depths is by assigning bright passages to instruments that are easily heard over light accompanying textures or are sometimes featured in solos or duets. The soprano saxophone and vibraphone are the two most common examples of this. Bioluminescence is written in the tradition of an orchestral tone poem, in that we move from one section to the next in a progression that changes in themes and orchestration but that allows cohesion between the “movements” so that the work can be understood as a whole. In Two Lights we meet our first bioluminescent creatures that we will follow throughout the work, two small and blue-glowing krill that float seemingly aimlessly throughout the deep as they search for food in the form of “marine snow”. Denizens of a Liquid Night introduces us to a variety of new and strange creatures; the most sinister of these is the monstrous Angler Fish, which is portrayed by the bassoons and bass clarinet as they play their brooding quartet on repeated occasions. As the illuminated krill swim to safety they discover a new arena of feeding grounds and marine richness in Pathfinder. The middle section of the piece is comprised of two fast sections which share material. The first of these sections, Tricks and Traps is an aggressive look at the hunters who patrol the dark waters and the devious tactics they use to lure prey into deadly traps. In Vampire! we meet one of the predators, Vampyroteuthis infernalis, or Vampire Squid who uses his glowing blue lures to seduce prey into his clutches. The work concludes with Song of the Luminescent which is a reiteration of some of the themes as our glowing krill float among an endless sea of bioluminescent jellyfish, illuminating the water like a city of hanging lamps.

Subjects/Keywords: orchestra; bioluminescence

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APA (6^th Edition):

Pfeifer, Z. (2010). Bioluminescence. (Masters Thesis). Louisiana State University. Retrieved from etd-04272010-231859 ; https://digitalcommons.lsu.edu/gradschool_theses/2293

Chicago Manual of Style (16^th Edition):

Pfeifer, Zachary. “Bioluminescence.” 2010. Masters Thesis, Louisiana State University. Accessed February 28, 2021. etd-04272010-231859 ; https://digitalcommons.lsu.edu/gradschool_theses/2293.

MLA Handbook (7^th Edition):

Pfeifer, Zachary. “Bioluminescence.” 2010. Web. 28 Feb 2021.

Vancouver:

Pfeifer Z. Bioluminescence. [Internet] [Masters thesis]. Louisiana State University; 2010. [cited 2021 Feb 28]. Available from: etd-04272010-231859 ; https://digitalcommons.lsu.edu/gradschool_theses/2293.

Council of Science Editors:

Pfeifer Z. Bioluminescence. [Masters Thesis]. Louisiana State University; 2010. Available from: etd-04272010-231859 ; https://digitalcommons.lsu.edu/gradschool_theses/2293

University of New South Wales

14. Jones, Luke. Development of an improved xenograft model for the treatment of paediatric ALL.

Degree: Women's & Children's Health, 2015, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/55680 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38475/SOURCE02?view=true

► Approximately 20% of children diagnosed with acute lymphoblastic leukaemia (ALL) will either fail to respond to treatment or will subsequently relapse. The considerable heterogeneity in… (more)

▼ Approximately 20% of children diagnosed with acute lymphoblastic leukaemia (ALL) will either fail to respond to treatment or will subsequently relapse. The considerable heterogeneity in molecular aberrations underlying these high-risk cases, as well as limited patient availability, complicates the clinical evaluation of novel therapies in this disease. Robust preclinical models of paediatric ALL able to accurately predict clinical efficacy of such agents are therefore required to advance only the most promising agents to clinical trial.The development of patient-derived xenograft (PDX) models of paediatric ALL has provided a clinically relevant, relatively high-throughput platform for assessing the efficacy of novel agents. By using immune-deficient mice as avatars of the human disease, these models allow monitoring of drug efficacy in real-time through the enumeration of human cells in mouse peripheral blood (PB). However, recent reports have suggested that incorporation of an in vivo imaging component to such models can further enhance their utility by allowing real-time monitoring of disease burden in multiple organs and tissues, allowing a more comprehensive assessment of treatment response. Therefore, this study aimed to introduce a bioluminescence imaging (BLI)-based in vivo imaging capability into established paediatric ALL PDXs. Monitoring of leukaemia burden by BLI was subsequently compared to PB-based measures in order to identify benefits provided by BLI in assessing treatment response to established and novel drugs and drug combinations.The results presented herein show that bioluminescence imaging (BLI) considerably enhanced detection of leukaemia burden over PB measures alone, and identified sites of residual disease during treatment in a quantitative manner. Treatment monitoring by BLI also highlighted the potential for over-estimation of drug efficacy when using PB-based measurements of treatment response, identifying considerable persistent disease during time-points where leukaemia was not detectable in the PB. Overall, the work outlined in this study indicates that BLI enhances the utility of the ALL PDX model in examining preclinical efficacy of novel drugs, allowing for increased stringency of preclinical drug testing to accurately prioritise agents for clinical trials. Advisors/Committee Members: Lock, Richard, Children's Cancer Institute Australia for Medical Research, Faculty of Medicine, UNSW, Fletcher, Jamie, Children's Cancer Institute Australia for Medical Research, Faculty of Medicine, UNSW, Carol, Hernan, Children's Cancer Institute Australia for Medical Research, Faculty of Medicine, UNSW.

Subjects/Keywords: Bioluminescence Imaging; Leukaemia; Paediatric

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APA (6^th Edition):

Jones, L. (2015). Development of an improved xenograft model for the treatment of paediatric ALL. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/55680 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38475/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Jones, Luke. “Development of an improved xenograft model for the treatment of paediatric ALL.” 2015. Doctoral Dissertation, University of New South Wales. Accessed February 28, 2021. http://handle.unsw.edu.au/1959.4/55680 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38475/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Jones, Luke. “Development of an improved xenograft model for the treatment of paediatric ALL.” 2015. Web. 28 Feb 2021.

Vancouver:

Jones L. Development of an improved xenograft model for the treatment of paediatric ALL. [Internet] [Doctoral dissertation]. University of New South Wales; 2015. [cited 2021 Feb 28]. Available from: http://handle.unsw.edu.au/1959.4/55680 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38475/SOURCE02?view=true.

Council of Science Editors:

Jones L. Development of an improved xenograft model for the treatment of paediatric ALL. [Doctoral Dissertation]. University of New South Wales; 2015. Available from: http://handle.unsw.edu.au/1959.4/55680 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:38475/SOURCE02?view=true

University of Aberdeen

15. Porteous, Fiona. Use of lux-marked rhizobacteria to investigate rhizosphere C-flow.

Degree: PhD, 1998, University of Aberdeen

URL: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152747270005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287702

► The aim of this study was to develop a protocol for the use of a lux-marked pseudomonad for the investigation of rhizosphere C-fluxes, and then… (more)

▼ The aim of this study was to develop a protocol for the use of a lux-marked pseudomonad for the investigation of rhizosphere C-fluxes, and then use this to examine a system experiencing change in C flow due to pollutant pressure. In this study a typical rhizobacterium, Pseudomonas fluorescens, was marked by the insertion of the lux gene cassette of Vibrio fischeri. Two constructs were produced, P. fluorescens pUCD607 (marked with the full lux gene cassette of CDABE) and P. fluorescens FAC510 (chromosomally marked with the lux AB genes), both with bioluminescence directly linked to metabolic activity. The bioluminescence response of C-starved suspensions of these constructs to typical rhizosphere C substrates, was determined by exposure of the cells to substrate over a 30 minute period. It was shown that P. fluorescens pUCD607 can distinguish between substrate type and concentration, in terms of bioluminescence. In terms of Michaelis-Menten kinetics, glucose had a Km of 30.4mMC, and a Vmax of 200 RLU's/mMC. However, an amino acid (glutamic acid) produced a Vmax of 23316 RLU's/mMC, and a Km of 1mMC. Succinic acid, an organic acid, caused a much lower Vmax in P. fluorescens pUCD607 of 240 RLU's/mMC, and a Km of 2.5mMC. Clearly, this reporter construct offers great potential for modelling rhizosphere C-flow, as indicated by the data shown. Following this, P. fluorescens pUCD607 was used to investigate the effects of pollutant stress on rhizosphere C-flow. Plantago lanceolata was treated with paraquat and sodium arsenate, two common soil pollutants. Both caused an increase in root exudate C from 20-350%, depending on application time and concentration. P. fluorescens pUCD607 was able to detect this change, with bioluminescence directly correlated to actual C concentration. This study demonstrates that P. fluorescens pUCD607 offers a valuable tool for the reliable investigation of rhizosphere C-flow, and that lux gene technology offers the potential to further model the rhizosphere. This novel technique opens up many possibilities for applications in monitoring of ecosystem health, organic agriculture and bioremediation.

Subjects/Keywords: 580; Bioluminescence

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APA (6^th Edition):

Porteous, F. (1998). Use of lux-marked rhizobacteria to investigate rhizosphere C-flow. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152747270005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287702

Chicago Manual of Style (16^th Edition):

Porteous, Fiona. “Use of lux-marked rhizobacteria to investigate rhizosphere C-flow.” 1998. Doctoral Dissertation, University of Aberdeen. Accessed February 28, 2021. https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152747270005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287702.

MLA Handbook (7^th Edition):

Porteous, Fiona. “Use of lux-marked rhizobacteria to investigate rhizosphere C-flow.” 1998. Web. 28 Feb 2021.

Vancouver:

Porteous F. Use of lux-marked rhizobacteria to investigate rhizosphere C-flow. [Internet] [Doctoral dissertation]. University of Aberdeen; 1998. [cited 2021 Feb 28]. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152747270005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287702.

Council of Science Editors:

Porteous F. Use of lux-marked rhizobacteria to investigate rhizosphere C-flow. [Doctoral Dissertation]. University of Aberdeen; 1998. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12152747270005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287702

University of Aberdeen

16. Craig, Jessica. Distribution of deep-sea bioluminescence across the Mid-Atlantic Ridge and Mediterranean Sea : relationships with surface productivity, topography and hydrography.

Degree: PhD, 2012, University of Aberdeen

URL: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153047650005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569785

► Bioluminescence is widespread in the deep sea. In this study, the density of bioluminescent zooplankton (BL) in the deep Mediterranean Sea (MS) and at the… (more)

Subjects/Keywords: 572.4358; Bioluminescence; Underwater exploration

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APA (6^th Edition):

Craig, J. (2012). Distribution of deep-sea bioluminescence across the Mid-Atlantic Ridge and Mediterranean Sea : relationships with surface productivity, topography and hydrography. (Doctoral Dissertation). University of Aberdeen. Retrieved from https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153047650005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569785

Chicago Manual of Style (16^th Edition):

Craig, Jessica. “Distribution of deep-sea bioluminescence across the Mid-Atlantic Ridge and Mediterranean Sea : relationships with surface productivity, topography and hydrography.” 2012. Doctoral Dissertation, University of Aberdeen. Accessed February 28, 2021. https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153047650005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569785.

MLA Handbook (7^th Edition):

Craig, Jessica. “Distribution of deep-sea bioluminescence across the Mid-Atlantic Ridge and Mediterranean Sea : relationships with surface productivity, topography and hydrography.” 2012. Web. 28 Feb 2021.

Vancouver:

Craig J. Distribution of deep-sea bioluminescence across the Mid-Atlantic Ridge and Mediterranean Sea : relationships with surface productivity, topography and hydrography. [Internet] [Doctoral dissertation]. University of Aberdeen; 2012. [cited 2021 Feb 28]. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153047650005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569785.

Council of Science Editors:

Craig J. Distribution of deep-sea bioluminescence across the Mid-Atlantic Ridge and Mediterranean Sea : relationships with surface productivity, topography and hydrography. [Doctoral Dissertation]. University of Aberdeen; 2012. Available from: https://abdn.alma.exlibrisgroup.com/view/delivery/44ABE_INST/12153047650005941 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569785

17. Akkoul, Smaïl. Filtrage et déconvolution en imagerie de bioluminescence chez le petit animal : Filtering and deconvolution for bioluminescence imaging of small animals.

Degree: Docteur es, Automatique et traitement du signal, 2010, Université d'Orléans

URL: http://www.theses.fr/2010ORLE2015

►

Cette thèse est consacrée au traitement d’images de bioluminescence chez le petit animal. Ce type d’imagerie, bien qu'utilisé en routine pour la recherche en cancérologie… (more)

▼

Cette thèse est consacrée au traitement d’images de bioluminescence chez le petit animal. Ce type d’imagerie, bien qu'utilisé en routine pour la recherche en cancérologie par exemple, présente néanmoins des problèmes liés aux phénomènes de diffusion et d'absorption par les tissus internes à l'animal. Il s'ajoute à cela le bruit du système d'acquisition ainsi que le bruit lié aux rayonnements cosmiques. Ceci influe sur la qualité des images acquises et rend leur exploitation délicate. Le but de cette thèse est de compenser ces effets perturbateurs. Les travaux menés ont abouti à la proposition d’un modèle de formation des images de bioluminescence ainsi qu’à une chaîne de traitement adaptée composée d’une étape de filtrage suivie d’une étape de déconvolution. Après étude de la nature des différents bruits liés à l'acquisition, nous avons mis au point un nouveau filtre médian pour la suppression du bruit impulsionnel aléatoire présent sur les images acquises ; ce filtre représente le premier bloc de la chaîne proposée. Pour l'étape de déconvolution, nous avons mené une étude comparative de différents algorithmes de déconvolution. Cela a conduit à choisir un algorithme de déconvolution aveugle initialisé avec la réponse impulsionnelle estimée du système d'acquisition. Nous avons validé notre approche globale en comparant les résultats à la réalité terrain. Au travers de différents essais cliniques, nous avons montré que le traitement que nous proposons permet une amélioration significative de la mesure des sources bioluminescentes et une meilleure distinction de sources très proches, ce qui représente un apport non négligeable pour les utilisateurs d'images de bioluminescence.

This thesis is devoted to the analysis of bioluminescence images applied to the small animal. This kind of imaging modality is used in cancerology studies. Nevertheless, some problems are related to the diffusion and the absorption of the tissues of the light of internal bioluminescent sources. In addition, system noise and the cosmic rays noise are present. This influences the quality of the images and makes it difficult to analyze. The purpose of this thesis is to overcome these disturbing effects. We first have proposed an image formation model for the bioluminescence images. The processing chain is constituted by a filtering stage followed by a deconvolution stage. We have proposed a new median filter to suppress the random value impulsive noise which corrupts the acquired images; this filter represents the first block of the proposed chain. For the deconvolution stage, we have performed a comparative study of various deconvolution algorithms. It allowed us to choose a blind deconvolution algorithm initialized with the estimated point spread function of the acquisition system. At first, we have validated our global approach by comparing our obtained results with the ground truth. Through various clinical tests, we have shown that the processing chain allows a significant improvement of the spatial resolution and a better distinction of very…

Advisors/Committee Members: Harba, Rachid (thesis director).

Subjects/Keywords: Imagerie par bioluminescence; Petit animal; Bioluminescence imaging; Small animal

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APA (6^th Edition):

Akkoul, S. (2010). Filtrage et déconvolution en imagerie de bioluminescence chez le petit animal : Filtering and deconvolution for bioluminescence imaging of small animals. (Doctoral Dissertation). Université d'Orléans. Retrieved from http://www.theses.fr/2010ORLE2015

Chicago Manual of Style (16^th Edition):

Akkoul, Smaïl. “Filtrage et déconvolution en imagerie de bioluminescence chez le petit animal : Filtering and deconvolution for bioluminescence imaging of small animals.” 2010. Doctoral Dissertation, Université d'Orléans. Accessed February 28, 2021. http://www.theses.fr/2010ORLE2015.

MLA Handbook (7^th Edition):

Akkoul, Smaïl. “Filtrage et déconvolution en imagerie de bioluminescence chez le petit animal : Filtering and deconvolution for bioluminescence imaging of small animals.” 2010. Web. 28 Feb 2021.

Vancouver:

Akkoul S. Filtrage et déconvolution en imagerie de bioluminescence chez le petit animal : Filtering and deconvolution for bioluminescence imaging of small animals. [Internet] [Doctoral dissertation]. Université d'Orléans; 2010. [cited 2021 Feb 28]. Available from: http://www.theses.fr/2010ORLE2015.

Council of Science Editors:

Akkoul S. Filtrage et déconvolution en imagerie de bioluminescence chez le petit animal : Filtering and deconvolution for bioluminescence imaging of small animals. [Doctoral Dissertation]. Université d'Orléans; 2010. Available from: http://www.theses.fr/2010ORLE2015

18. Michel, Grégory. Leishmaniose à Leishmania infantum : portage asymptomatique, vaccination par voie endonasale et apport de la bioluminescence : Experimental study of the behaviour and the evaporation of a liquid fuel film in the presence of a flame.

Degree: Docteur es, Pathologie Humaine, 2011, Aix-Marseille 2

URL: http://www.theses.fr/2011AIX20723

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La leishmaniose viscérale (LV) à Leishmania infantum est une zoonose qui sévit notamment autour du bassin méditerranéen. Elle atteint principalement le chien, qui représente le… (more)

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La leishmaniose viscérale (LV) à Leishmania infantum est une zoonose qui sévit notamment autour du bassin méditerranéen. Elle atteint principalement le chien, qui représente le réservoir de l’infection. Chez l’homme, si la forme patente est rare, il existe de nombreux sujets porteurs asymptomatiques dans les zones d’endémies. Au cours de ce travail, nous avons abordé 3 problématiques importantes concernant la LV. La première problématique à porté sur l’importance du portage asymptotique humain à L. infantum au niveau mondial et de ses conséquences. Notre étude montre que la fréquence de porteurs asymptomatiques dépend des tests de détection utilisés et des populations étudiées et qu'elle peut atteindre jusqu'à 70% dans certaines zones d’endémies. Elle montre également que la transmission du parasite par don de sang est peu probable et que le rôle du portage asymptomatique comme réservoir n’est pas encore démontré. Elle souligne également la nécessité de détecter le portage asymptotique chez le donneur et le receveur de greffe et le risque de développement de la forme patente chez l’asymptomatique déprimé. La deuxième problématique porte sur le développement de procédés vaccinaux contre L. infantum par voie endonasale chez la souris BALB/c. Nos résultats montrent que la vaccination par voie nasale induit de manière reproductible une immunité systémique, cellulaire et humorale et que la protection dépend de paramètres tels que la nature et la dose des antigènes utilisées et la présence d’adjuvant tels que le CNF et le MPL. Enfin, la sélection d’une infection intradermique permet d’améliorer significativement la protection.La troisième partie porte sur la mise au point de modèles expérimentaux d’infection basés sur l’utilisation de parasites recombinants exprimant le gène de la luciférase. Nos travaux montrent que l’utilisation de tels outils permet de suivre l’infection à L. infantum in vitro, ex vivo et in vivo chez la souris BALB/c et de ce fait sont utiles pour le criblage de médicaments comme la miltéfosine et potentiellement pour tester des préparations vaccinales. Cet outil nous a permis en outre de révéler un nouveau site de prolifération parasitaire.

Visceral leishmaniasis (VL) caused by L. infantum is a zoonotic disease present in the Mediterranean basin (LVM). Dogs represent the reservoir and the main victim of the disease. In man, besides a limited number of cases of patent VL, a great number of infection remains asymptomatic. In this report, three different aspects of VL have been studied.First, the prevalence and the consequences of asymptomatic carriers of L. infantum was evaluated worldwide. The prevalence of asymptomatic carriers depends on the selected detection tests and the studied population and can reach 70% in some endemic zones. Our study also shows that the role of asymptomatic carriers as reservoirs remains to be established. However, in immunocompromised asymptomatic carriers such as HIV positive individuals, infection can be reactivated.Second, we developed vaccine trials against L.…

Advisors/Committee Members: Marty, Pierre (thesis director), Lemichez, Emmanuel (thesis director).

Subjects/Keywords: Leishmaniose; Asymptomatique; Vaccination; Endonasale; Bioluminescence; Leishmaniasis; Asymptomatic; Vaccination; Endonasal; Bioluminescence

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Michel, G. (2011). Leishmaniose à Leishmania infantum : portage asymptomatique, vaccination par voie endonasale et apport de la bioluminescence : Experimental study of the behaviour and the evaporation of a liquid fuel film in the presence of a flame. (Doctoral Dissertation). Aix-Marseille 2. Retrieved from http://www.theses.fr/2011AIX20723

Chicago Manual of Style (16^th Edition):

Michel, Grégory. “Leishmaniose à Leishmania infantum : portage asymptomatique, vaccination par voie endonasale et apport de la bioluminescence : Experimental study of the behaviour and the evaporation of a liquid fuel film in the presence of a flame.” 2011. Doctoral Dissertation, Aix-Marseille 2. Accessed February 28, 2021. http://www.theses.fr/2011AIX20723.

MLA Handbook (7^th Edition):

Michel, Grégory. “Leishmaniose à Leishmania infantum : portage asymptomatique, vaccination par voie endonasale et apport de la bioluminescence : Experimental study of the behaviour and the evaporation of a liquid fuel film in the presence of a flame.” 2011. Web. 28 Feb 2021.

Vancouver:

Michel G. Leishmaniose à Leishmania infantum : portage asymptomatique, vaccination par voie endonasale et apport de la bioluminescence : Experimental study of the behaviour and the evaporation of a liquid fuel film in the presence of a flame. [Internet] [Doctoral dissertation]. Aix-Marseille 2; 2011. [cited 2021 Feb 28]. Available from: http://www.theses.fr/2011AIX20723.

Council of Science Editors:

Michel G. Leishmaniose à Leishmania infantum : portage asymptomatique, vaccination par voie endonasale et apport de la bioluminescence : Experimental study of the behaviour and the evaporation of a liquid fuel film in the presence of a flame. [Doctoral Dissertation]. Aix-Marseille 2; 2011. Available from: http://www.theses.fr/2011AIX20723

19. Tanet, Lisa. La bioluminescence bactérienne, des océans à Biolum-Archi : un phénomène biologique fascinant au service d'un modèle d'habitat durable méditerranéen? : Bacterial bioluminescence, from oceans to Biolum-Archi : a fascinating phenomenon at the service of a mediterranean-sustainable-habitat model ?.

Degree: Docteur es, Océanographie, 2020, Aix Marseille Université

URL: http://www.theses.fr/2020AIXM0121

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La bioluminescence, production de lumière visible par des organismes vivants, est un phénomène fascinant, en particulier chez les bactéries qui l’émettent de façon continue. Pour… (more)

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La bioluminescence, production de lumière visible par des organismes vivants, est un phénomène fascinant, en particulier chez les bactéries qui l’émettent de façon continue. Pour ce projet interdisciplinaire, ces travaux de thèse ont mêlé recherche fondamentale et appliquée, et se sont articulés autour de la problématique suivante : la bioluminescence bactérienne peut-elle être mise au service d’un modèle d’habitat durable ?Ce manuscrit se compose (i) d’un premier chapitre introductif sur le phénomène de bioluminescence, intégrant notamment une synthèse bibliographique sur l’importance écologique des bactéries bioluminescentes dans le milieu marin ; (ii) d’un second chapitre montrant que les gènes impliqués dans la bioluminescence ne sont pas toujours régulés par le quorum sensing ; (iii) d’un troisième chapitre se focalisant sur les effets de l’oxygène sur la physiologie de la souche modèle (iv) d’un quatrième chapitre regroupant les informations relatives à une application de la bioluminescence bactérienne et les prototypes développés au cours de cette thèse. Dans ce dernier chapitre, les avantages, ainsi que les limites actuelles, de l’utilisation de la bioluminescence comme source d’éclairage sont énoncés. Les résultats obtenus au cours de ces trois années ont mis en avant des premiers éléments de réponse et ont permis d’acquérir de nouvelles connaissances sur la souche utilisée, et sur les bactéries bioluminescentes d’une façon générale. Ces travaux visent à être poursuivis et approfondis par d’autres recherches, davantage encore axées vers un objectif pratique et appliqué de la bioluminescence.

Bioluminescence, the emission of light by living organisms, is a fascinating phenomenon, especially in bacteria that emit it continuously.For this interdisciplinary project, this thesis work mixed fundamental and applied research, and was structured around the following problem: can bacterial bioluminescence be used at the service of a sustainable-habitat model? This manuscript is composed of (i) a first introductory chapter on the bioluminescence phenomenon, including a bibliographical synthesis on the ecological importance of bioluminescent bacteria in the marine environment; (ii) a second chapter showing that the genes involved in bioluminescence are not, in P. photobacterium ANT-2200, under quorum sensing control; (iii) a third chapter focusing on the effects of oxygen on the physiology of the model strain through the use of an semi-automated culture platform allowing controlled and regulated conditionsb; (iv) a fourth chapter gathering information relating to an application of bacterial bioluminescence and the prototypes developed during this thesis. In this last chapter, the advantages, as well as the current limitations, of the use of bioluminescence as a source of illumination are stated. The results obtained during these three years have highlighted initial elements of response and have led to new knowledge on the used strain, and on bioluminescent bacteria in general. This work is intended to be continued…

Advisors/Committee Members: Tamburini, Christian (thesis director), Casalot, Laurie (thesis director).

Subjects/Keywords: Bioluminescence; Bactéries; Photobacterium; Biotechnologies; Bioluminescence; Bacteria; Photobacterium; Applied technology; 550

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tanet, L. (2020). La bioluminescence bactérienne, des océans à Biolum-Archi : un phénomène biologique fascinant au service d'un modèle d'habitat durable méditerranéen? : Bacterial bioluminescence, from oceans to Biolum-Archi : a fascinating phenomenon at the service of a mediterranean-sustainable-habitat model ?. (Doctoral Dissertation). Aix Marseille Université. Retrieved from http://www.theses.fr/2020AIXM0121

Chicago Manual of Style (16^th Edition):

Tanet, Lisa. “La bioluminescence bactérienne, des océans à Biolum-Archi : un phénomène biologique fascinant au service d'un modèle d'habitat durable méditerranéen? : Bacterial bioluminescence, from oceans to Biolum-Archi : a fascinating phenomenon at the service of a mediterranean-sustainable-habitat model ?.” 2020. Doctoral Dissertation, Aix Marseille Université. Accessed February 28, 2021. http://www.theses.fr/2020AIXM0121.

MLA Handbook (7^th Edition):

Tanet, Lisa. “La bioluminescence bactérienne, des océans à Biolum-Archi : un phénomène biologique fascinant au service d'un modèle d'habitat durable méditerranéen? : Bacterial bioluminescence, from oceans to Biolum-Archi : a fascinating phenomenon at the service of a mediterranean-sustainable-habitat model ?.” 2020. Web. 28 Feb 2021.

Vancouver:

Tanet L. La bioluminescence bactérienne, des océans à Biolum-Archi : un phénomène biologique fascinant au service d'un modèle d'habitat durable méditerranéen? : Bacterial bioluminescence, from oceans to Biolum-Archi : a fascinating phenomenon at the service of a mediterranean-sustainable-habitat model ?. [Internet] [Doctoral dissertation]. Aix Marseille Université 2020. [cited 2021 Feb 28]. Available from: http://www.theses.fr/2020AIXM0121.

Council of Science Editors:

Tanet L. La bioluminescence bactérienne, des océans à Biolum-Archi : un phénomène biologique fascinant au service d'un modèle d'habitat durable méditerranéen? : Bacterial bioluminescence, from oceans to Biolum-Archi : a fascinating phenomenon at the service of a mediterranean-sustainable-habitat model ?. [Doctoral Dissertation]. Aix Marseille Université 2020. Available from: http://www.theses.fr/2020AIXM0121

University of Minnesota

20. Astuti, Yuliana Sakti Dwi. In vivo assessment of hematopoietic cell homing and engraftment in zebrafish using bioluminescence imaging.

Degree: 2013, University of Minnesota

URL: http://purl.umn.edu/156564

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University of Minnesota M.S. thesis. May 2013. Major:Stem Cell Biology. Advisor: Troy Lund. 1 computer file (PDF); v, 33 pages.

Hematopoietic cell transplantation (HCT) has… (more)

Subjects/Keywords: Bioluminescence imaging; Hematopoietic cell transplant; Zebrafish

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Astuti, Y. S. D. (2013). In vivo assessment of hematopoietic cell homing and engraftment in zebrafish using bioluminescence imaging. (Masters Thesis). University of Minnesota. Retrieved from http://purl.umn.edu/156564

Chicago Manual of Style (16^th Edition):

Astuti, Yuliana Sakti Dwi. “In vivo assessment of hematopoietic cell homing and engraftment in zebrafish using bioluminescence imaging.” 2013. Masters Thesis, University of Minnesota. Accessed February 28, 2021. http://purl.umn.edu/156564.

MLA Handbook (7^th Edition):

Astuti, Yuliana Sakti Dwi. “In vivo assessment of hematopoietic cell homing and engraftment in zebrafish using bioluminescence imaging.” 2013. Web. 28 Feb 2021.

Vancouver:

Astuti YSD. In vivo assessment of hematopoietic cell homing and engraftment in zebrafish using bioluminescence imaging. [Internet] [Masters thesis]. University of Minnesota; 2013. [cited 2021 Feb 28]. Available from: http://purl.umn.edu/156564.

Council of Science Editors:

Astuti YSD. In vivo assessment of hematopoietic cell homing and engraftment in zebrafish using bioluminescence imaging. [Masters Thesis]. University of Minnesota; 2013. Available from: http://purl.umn.edu/156564

University of California – Berkeley

21. Van de Bittner, Genevieve Crystal. Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease.

Degree: Chemistry, 2012, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/76v708pp

► The study of biological processes involved in the development and progression of disease has the potential to uncover new treatments or cures. While there are… (more)

▼ The study of biological processes involved in the development and progression of disease has the potential to uncover new treatments or cures. While there are many techniques to study biological analytes involved in disease states, molecular imaging offers tools that are amenable to imaging biological processes as they occur in living systems. Previously developed fluorescent molecular imaging tools have lead to an improved understanding of the roles of both hydrogen peroxide (H₂O₂) and copper in both normal physiological processes and in disease. However, most of these tools have been limited to the study of H₂O₂ and copper in cells or tissues. A more comprehensive understanding of molecular disease processes involved in disease states can be gleaned by studying animal models of human disease, as the affects of the disease on the entire organism can be monitored. This dissertation describes the design, synthesis, and characterization of bioluminescent and fluorescent molecular imaging tools for the detection of H₂O₂ and copper, and their application to the detection of these analytes in murine models of disease. In a first demonstration, Peroxy Caged Luciferin-1 is developed using a firefly luciferin probe scaffold and utilized to monitor increased H₂O₂ production in androgen-sensitive prostate tumors following stimulation with a growth-inducing compound, testosterone. Using a new approach for firefly luminescence imaging, in situ formation of firefly luciferin, two unique probes, Peroxy Caged Luciferin-2 and IETDC, are developed for simultaneous imaging of H₂O₂ and caspase 8 activity in a model of sepsis. Development of a third luminescence-based probe for H₂O₂ detection, Peroxy Caged Luciferin-3, offers a tool for the detection of H₂O₂ in the brain of mice, with possible applications for studying H₂O₂ during seizure. Finally, development of a near-infrared fluorescent probe for detection of copper in vivo is discussed and applied to the detection of alterations in copper levels during the development and treatment of a murine Wilson's disease model.

Subjects/Keywords: Chemistry; bioluminescence; copper; fluorescence; hydrogen peroxide; imaging

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Van de Bittner, G. C. (2012). Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/76v708pp

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Van de Bittner, Genevieve Crystal. “Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease.” 2012. Thesis, University of California – Berkeley. Accessed February 28, 2021. http://www.escholarship.org/uc/item/76v708pp.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Van de Bittner, Genevieve Crystal. “Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease.” 2012. Web. 28 Feb 2021.

Vancouver:

Van de Bittner GC. Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease. [Internet] [Thesis]. University of California – Berkeley; 2012. [cited 2021 Feb 28]. Available from: http://www.escholarship.org/uc/item/76v708pp.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Van de Bittner GC. Molecular Imaging Approaches toward Optical Detection of Hydrogen Peroxide and Copper in Murine Models of Disease. [Thesis]. University of California – Berkeley; 2012. Available from: http://www.escholarship.org/uc/item/76v708pp

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Mississippi State University

22. Duoss, Heather Ann. VALIDATION OF BIOLUMINESCENT ESCHERICHIA COLI O157:H7 FOR USE AS A PRE-HARVEST FOOD SAFETY MODEL.

Degree: MS, Animal and Dairy Sciences, 2012, Mississippi State University

URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03272012-115337/ ;

► Cattle are naturally colonized by enterohemorrhagic Escherichia coli within the gastrointestinal tract. The most notorious of the enterohemorrhagic E. coli is E. coli O157:H7,… (more)

Subjects/Keywords: O157:H7; pre-harvest; Escherichia coli; Bioluminescence

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APA (6^th Edition):

Duoss, H. A. (2012). VALIDATION OF BIOLUMINESCENT ESCHERICHIA COLI O157:H7 FOR USE AS A PRE-HARVEST FOOD SAFETY MODEL. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-03272012-115337/ ;

Chicago Manual of Style (16^th Edition):

Duoss, Heather Ann. “VALIDATION OF BIOLUMINESCENT ESCHERICHIA COLI O157:H7 FOR USE AS A PRE-HARVEST FOOD SAFETY MODEL.” 2012. Masters Thesis, Mississippi State University. Accessed February 28, 2021. http://sun.library.msstate.edu/ETD-db/theses/available/etd-03272012-115337/ ;.

MLA Handbook (7^th Edition):

Duoss, Heather Ann. “VALIDATION OF BIOLUMINESCENT ESCHERICHIA COLI O157:H7 FOR USE AS A PRE-HARVEST FOOD SAFETY MODEL.” 2012. Web. 28 Feb 2021.

Vancouver:

Duoss HA. VALIDATION OF BIOLUMINESCENT ESCHERICHIA COLI O157:H7 FOR USE AS A PRE-HARVEST FOOD SAFETY MODEL. [Internet] [Masters thesis]. Mississippi State University; 2012. [cited 2021 Feb 28]. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03272012-115337/ ;.

Council of Science Editors:

Duoss HA. VALIDATION OF BIOLUMINESCENT ESCHERICHIA COLI O157:H7 FOR USE AS A PRE-HARVEST FOOD SAFETY MODEL. [Masters Thesis]. Mississippi State University; 2012. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03272012-115337/ ;

Cornell University

23. Pender, Mitchell Alan. GENETICALLY ENCODABLE CHROMATIC LUMINESCENCE FOR NEURAL ACTIVITY MAPPING.

Degree: PhD, Biomedical Engineering, 2019, Cornell University

URL: http://hdl.handle.net/1813/67417

► The brain is the most complex organ in the human body. Composed of intricate overlapping networks existing on multiple spatiotemporal and philosophical scales, a comprehensive… (more)

Subjects/Keywords: calcium; Bioluminescence; Brain; Biomedical engineering; Fluorescence; light

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pender, M. A. (2019). GENETICALLY ENCODABLE CHROMATIC LUMINESCENCE FOR NEURAL ACTIVITY MAPPING. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/67417

Chicago Manual of Style (16^th Edition):

Pender, Mitchell Alan. “GENETICALLY ENCODABLE CHROMATIC LUMINESCENCE FOR NEURAL ACTIVITY MAPPING.” 2019. Doctoral Dissertation, Cornell University. Accessed February 28, 2021. http://hdl.handle.net/1813/67417.

MLA Handbook (7^th Edition):

Pender, Mitchell Alan. “GENETICALLY ENCODABLE CHROMATIC LUMINESCENCE FOR NEURAL ACTIVITY MAPPING.” 2019. Web. 28 Feb 2021.

Vancouver:

Pender MA. GENETICALLY ENCODABLE CHROMATIC LUMINESCENCE FOR NEURAL ACTIVITY MAPPING. [Internet] [Doctoral dissertation]. Cornell University; 2019. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1813/67417.

Council of Science Editors:

Pender MA. GENETICALLY ENCODABLE CHROMATIC LUMINESCENCE FOR NEURAL ACTIVITY MAPPING. [Doctoral Dissertation]. Cornell University; 2019. Available from: http://hdl.handle.net/1813/67417

Vanderbilt University

24. Virostko, John Michael. Assessment of pancreatic islet transplants using in vivo bioluminescence imaging.

Degree: MS, Biomedical Engineering, 2003, Vanderbilt University

URL: http://hdl.handle.net/1803/15052

► Pancreatic islet transplantation is a promising treatment for type 1 diabetes. However, current efforts to study islet transplantations are hampered by the lack of a… (more)

▼ Pancreatic islet transplantation is a promising treatment for type 1 diabetes. However, current efforts to study islet transplantations are hampered by the lack of a non-invasive method of imaging islets and quantifying islet mass post transplantation. Transplanted pancreatic islets can be imaged and quantified non-invasively using in vivo bioluminescence imaging (BLI). Pancreatic islets transfected with the firefly reporter gene, luciferase, emit light that can be quantified using photon-counting measurements. Pancreatic islet number is linearly related to light emission both in vitro and in vivo. Application of bioluminescence imaging for this application can be greatly enhanced by relating light emission to the number of islets surviving post-transplantation. Determining this relationship requires detailed knowledge of the factors that influence photon-counting measurements. Bioluminescence was modeled using constant light emitting phosphorescent beads implanted at the two common sites of islet transplantation: the renal capsule and liver. This model was used to quantify light attenuation by tissues overlying the islet transplantations. The ratio of implanted light emission to in vitro light emission was found to be .2394+/- 0.0261 for renal implantation and 0.0645 +/- 0.0140 for hepatic implants. Mathematical modeling of light propagation using Monte Carlo simulation is in excellent agreement with these experimental results. Monte Carlo modeling yields an in vivo to in vitro luminescence ratio for renal and hepatic sources to be 0.2860 and 0.0495, respectively. Surgical artifacts were found to influence bioluminescence measurements. Surgical scar tissue leads to lower light emission the week immediately post-op, but this attenuation is negligible two weeks after surgery. The orientation of the subject also influences quantification of bioluminescence. Rotation of 50 degrees from flat can lead to a 73% decrease in light transmission for renal implants and 52% decrease for hepatic implants. The rate of luminescence decrease with increasing angle depends on the surface light is projected upon. Flatter surfaces lead to a slower decrease in luminescence while higher curvature leads to more rapid decrease in luminescence. Spot size of bioluminescence was found to increase with increasing tissue depth. The spot size of hepatic implants was found to be 17% larger than renal implants, as measured by full width at half maximum measurements. Constant light emission modeling of transplanted islet bioluminescence permits quantification of actual islet number from photon counting measurements and insight into factors which influence these measurements. Advisors/Committee Members: Al Powers (committee member), Duco Jansen (Committee Chair).

Subjects/Keywords: islet transplantation; bioluminescence

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Virostko, J. M. (2003). Assessment of pancreatic islet transplants using in vivo bioluminescence imaging. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/15052

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Virostko, John Michael. “Assessment of pancreatic islet transplants using in vivo bioluminescence imaging.” 2003. Thesis, Vanderbilt University. Accessed February 28, 2021. http://hdl.handle.net/1803/15052.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Virostko, John Michael. “Assessment of pancreatic islet transplants using in vivo bioluminescence imaging.” 2003. Web. 28 Feb 2021.

Vancouver:

Virostko JM. Assessment of pancreatic islet transplants using in vivo bioluminescence imaging. [Internet] [Thesis]. Vanderbilt University; 2003. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1803/15052.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Virostko JM. Assessment of pancreatic islet transplants using in vivo bioluminescence imaging. [Thesis]. Vanderbilt University; 2003. Available from: http://hdl.handle.net/1803/15052

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

25. Jones, Jeffrey Robert. Linking molecular, electrical, and behavioral rhythms in the brain’s biological clock.

Degree: PhD, Neuroscience, 2015, Vanderbilt University

URL: http://hdl.handle.net/1803/10633

► Understanding the relationship between gene networks, neurons, and circuits that determine behavior is a fundamental problem in neuroscience. The brain’s biological clock – the suprachiasmatic… (more)

Subjects/Keywords: firing rate; bioluminescence; suprachiasmatic; optogenetics; circadian

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Jones, J. R. (2015). Linking molecular, electrical, and behavioral rhythms in the brain’s biological clock. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10633

Chicago Manual of Style (16^th Edition):

Jones, Jeffrey Robert. “Linking molecular, electrical, and behavioral rhythms in the brain’s biological clock.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed February 28, 2021. http://hdl.handle.net/1803/10633.

MLA Handbook (7^th Edition):

Jones, Jeffrey Robert. “Linking molecular, electrical, and behavioral rhythms in the brain’s biological clock.” 2015. Web. 28 Feb 2021.

Vancouver:

Jones JR. Linking molecular, electrical, and behavioral rhythms in the brain’s biological clock. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1803/10633.

Council of Science Editors:

Jones JR. Linking molecular, electrical, and behavioral rhythms in the brain’s biological clock. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/10633

26. Ranjitha P. Isolation characterization and purification of extracellular lipolytic enzymes from marine bioluminescence bacteria.

Degree: Microbiology, 2015, Periyar University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/34981

NA newline Advisors/Committee Members: Mohankumar A.

Subjects/Keywords: BIOLUMINESCENCE BACTERIA; ISOLATION

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APA (6^th Edition):

P, R. (2015). Isolation characterization and purification of extracellular lipolytic enzymes from marine bioluminescence bacteria. (Thesis). Periyar University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/34981

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

P, Ranjitha. “Isolation characterization and purification of extracellular lipolytic enzymes from marine bioluminescence bacteria.” 2015. Thesis, Periyar University. Accessed February 28, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/34981.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

P, Ranjitha. “Isolation characterization and purification of extracellular lipolytic enzymes from marine bioluminescence bacteria.” 2015. Web. 28 Feb 2021.

Vancouver:

P R. Isolation characterization and purification of extracellular lipolytic enzymes from marine bioluminescence bacteria. [Internet] [Thesis]. Periyar University; 2015. [cited 2021 Feb 28]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/34981.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

P R. Isolation characterization and purification of extracellular lipolytic enzymes from marine bioluminescence bacteria. [Thesis]. Periyar University; 2015. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/34981

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Irvine

27. Rathbun, Colin. Multicomponent bioluminescence imaging via substrate resolution.

Degree: Chemistry, 2018, University of California – Irvine

URL: http://www.escholarship.org/uc/item/9fj4780n

► Genetically-encoded fluorescent probes have revolutionized our understanding of biological systems. However, the transition of fluorescent probes in vivo has been hampered by the opacity of… (more)

▼ Genetically-encoded fluorescent probes have revolutionized our understanding of biological systems. However, the transition of fluorescent probes in vivo has been hampered by the opacity of tissue and its propensity for autofluorescence. A complementary imaging technology, bioluminescence, does not suffer from these complications because it does not require excitation light. Thus, the technique is exquisitely sensitive–with the ability to see as few as ten cells in a mouse. Bioluminescence relies on luciferase enzymes that catalyze the oxidation of small-molecule substrates (luciferins), releasing photons of light in the process. Unfortunately, the optimal luciferases for in vivo use rely on the same luciferins, precluding studies of more than one feature at a time.To address this issue, I developed and analyzed a number of new luciferin probes, and created a selection platform to find mutually orthogonal luciferases and luciferins for multicomponent imaging. In contrast to the spectroscopic resolution of fluorescent tools, these probes were designed to exhibit substrate resolution. Combining luciferin analogs and mutant enzymes, we tested 20 luciferins with 207 luciferases, generating 4,140 enzyme-substrate combinations, and thus a potential for more than 4 million possible sets. Since it would be impractical to evaluate these manually, I derived a mathematical quantification of orthogonality to score each potential pairing. Next, I wrote a supercomputer algorithm to search this dataset for the highest-scoring pairs. The software provided a ranked list of mutually orthogonal enzyme-substrate pairs that were biochemically verified. Resolution was maintained when these probes were moved into mouse models, highlighting the speed and accuracy of my approach.My most recent work focused on increasing the practicality of these tools for preclinical imaging. The major drawbacks of our approach included temporal resolution and background emission. I addressed these issues by utilizing traditional spectral unmixing algorithms to deconvolute substrate signals mathematically. This enabled sequential imaging of substrates, and the ability to resolve smaller numbers of cells. With a top orthogonal pair I "unmixed" gradients of mutant luciferases in bacterial lysate and resolved mixtures of these mutants in mouse tumor models. These tools and algorithm will be useful for visualizing multiple cell types in mouse models.

Subjects/Keywords: Chemistry; Biochemistry; bioluminescence; imaging; luciferase; luciferin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rathbun, C. (2018). Multicomponent bioluminescence imaging via substrate resolution. (Thesis). University of California – Irvine. Retrieved from http://www.escholarship.org/uc/item/9fj4780n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rathbun, Colin. “Multicomponent bioluminescence imaging via substrate resolution.” 2018. Thesis, University of California – Irvine. Accessed February 28, 2021. http://www.escholarship.org/uc/item/9fj4780n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rathbun, Colin. “Multicomponent bioluminescence imaging via substrate resolution.” 2018. Web. 28 Feb 2021.

Vancouver:

Rathbun C. Multicomponent bioluminescence imaging via substrate resolution. [Internet] [Thesis]. University of California – Irvine; 2018. [cited 2021 Feb 28]. Available from: http://www.escholarship.org/uc/item/9fj4780n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rathbun C. Multicomponent bioluminescence imaging via substrate resolution. [Thesis]. University of California – Irvine; 2018. Available from: http://www.escholarship.org/uc/item/9fj4780n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Kuo, Alan J. Mutant analysis of luminescence and autoinduction in a marine bacterium.

Degree: 1994, MIT and Woods Hole Oceanographic Institution

URL: http://hdl.handle.net/1912/5626

► The marine symbiotic bacterium Vibrio fischeri is striking for its ability both to emit light and to dramatically regulate light emission using a cell-to-cell signalling… (more)

Subjects/Keywords: Bioluminescence; Marine bacteria

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kuo, A. J. (1994). Mutant analysis of luminescence and autoinduction in a marine bacterium. (Thesis). MIT and Woods Hole Oceanographic Institution. Retrieved from http://hdl.handle.net/1912/5626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kuo, Alan J. “Mutant analysis of luminescence and autoinduction in a marine bacterium.” 1994. Thesis, MIT and Woods Hole Oceanographic Institution. Accessed February 28, 2021. http://hdl.handle.net/1912/5626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kuo, Alan J. “Mutant analysis of luminescence and autoinduction in a marine bacterium.” 1994. Web. 28 Feb 2021.

Vancouver:

Kuo AJ. Mutant analysis of luminescence and autoinduction in a marine bacterium. [Internet] [Thesis]. MIT and Woods Hole Oceanographic Institution; 1994. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1912/5626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kuo AJ. Mutant analysis of luminescence and autoinduction in a marine bacterium. [Thesis]. MIT and Woods Hole Oceanographic Institution; 1994. Available from: http://hdl.handle.net/1912/5626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vrije Universiteit Amsterdam

29. Badr, C.E. Bioluminescence imaging in glioblastoma : monitoring of biological processes and novel therapeutics .

Degree: 2010, Vrije Universiteit Amsterdam

URL: http://hdl.handle.net/1871/16088

Subjects/Keywords: bioluminescence imaging; glioblastoma

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Badr, C. E. (2010). Bioluminescence imaging in glioblastoma : monitoring of biological processes and novel therapeutics . (Doctoral Dissertation). Vrije Universiteit Amsterdam. Retrieved from http://hdl.handle.net/1871/16088

Chicago Manual of Style (16^th Edition):

Badr, C E. “Bioluminescence imaging in glioblastoma : monitoring of biological processes and novel therapeutics .” 2010. Doctoral Dissertation, Vrije Universiteit Amsterdam. Accessed February 28, 2021. http://hdl.handle.net/1871/16088.

MLA Handbook (7^th Edition):

Badr, C E. “Bioluminescence imaging in glioblastoma : monitoring of biological processes and novel therapeutics .” 2010. Web. 28 Feb 2021.

Vancouver:

Badr CE. Bioluminescence imaging in glioblastoma : monitoring of biological processes and novel therapeutics . [Internet] [Doctoral dissertation]. Vrije Universiteit Amsterdam; 2010. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1871/16088.

Council of Science Editors:

Badr CE. Bioluminescence imaging in glioblastoma : monitoring of biological processes and novel therapeutics . [Doctoral Dissertation]. Vrije Universiteit Amsterdam; 2010. Available from: http://hdl.handle.net/1871/16088

Brigham Young University

30. Martin, Gavin Jon. A Molecular Phylogeny of Lampyridae with Insight into Visual and Bioluminescent Evolution.

Degree: MS, 2014, Brigham Young University

URL: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=6757&context=etd

► Fireflies are some of the most captivating organisms on the planet. Because of this, they have a rich history of study, especially concerning their bioluminescent… (more)

Subjects/Keywords: phylogeny; Coleoptera; Lampyridae; opsin; transcriptome; bioluminescence; Biology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Martin, G. J. (2014). A Molecular Phylogeny of Lampyridae with Insight into Visual and Bioluminescent Evolution. (Masters Thesis). Brigham Young University. Retrieved from https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=6757&context=etd

Chicago Manual of Style (16^th Edition):

Martin, Gavin Jon. “A Molecular Phylogeny of Lampyridae with Insight into Visual and Bioluminescent Evolution.” 2014. Masters Thesis, Brigham Young University. Accessed February 28, 2021. https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=6757&context=etd.

MLA Handbook (7^th Edition):

Martin, Gavin Jon. “A Molecular Phylogeny of Lampyridae with Insight into Visual and Bioluminescent Evolution.” 2014. Web. 28 Feb 2021.

Vancouver:

Martin GJ. A Molecular Phylogeny of Lampyridae with Insight into Visual and Bioluminescent Evolution. [Internet] [Masters thesis]. Brigham Young University; 2014. [cited 2021 Feb 28]. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=6757&context=etd.

Council of Science Editors:

Martin GJ. A Molecular Phylogeny of Lampyridae with Insight into Visual and Bioluminescent Evolution. [Masters Thesis]. Brigham Young University; 2014. Available from: https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=6757&context=etd

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Open Access Theses and Dissertations