subject:(Biology AND Life Sciences)

Johannes Gutenberg Universität Mainz

1. Hussein Allami, Risala. Influence of the chemokine CXCL12 on the progression and the signaling in colorectal cancer.

Degree: 2013, Johannes Gutenberg Universität Mainz

URL: http://ubm.opus.hbz-nrw.de/volltexte/2013/3489/

► Das Chemokin CXCL12 (auch bekannt als SDF-1) ist ein kleines Protein (8-14) KDa, das in sechs Isoformen exprimiert wird (SDF-1α, SDF-1β, SDF-1γ, SDF- 1δ, SDF-1ε… (more)

▼ Das Chemokin CXCL12 (auch bekannt als SDF-1) ist ein kleines Protein (8-14) KDa, das in sechs Isoformen exprimiert wird (SDF-1α, SDF-1β, SDF-1γ, SDF- 1δ, SDF-1ε und SDF-1θ) von einem einzigen Gen, dass die Leukozyten-Wanderung regelt und variabel in einer Reihe von normalen und Krebsgeweben exprimiert wird.rnCXCL12 spielt verschiedene Rollen in der Tumorpathogenese. Es wurde nachgewiesen, dass CXCL12 das Tumorwachstum und die Malignität fördert, die Tumorangiogenese stärkt, sich an der Metastasierung beteiligt und zu immunsuppressiven Netzwerken innerhalb des Tumormikromilieus beiträgt. Daher liegt es nahe, dass der CXCL12/CXCR4-Signalweg ein wichtiges Ziel ist für die Entwicklung von neuartigen Krebstherapien.rnUm Licht auf die Rolle der Chemokin CXCL12 Splicevarianten in der Entwicklung von Krebs zu werfen und die mögliche physiologische Relevanz und ihre möglichen funktionellen Unterschiede bei Darmkrebs zu verstehen, haben wir alle CXCL12 Splicevarianten (alpha, beta, gamma, delta, epsilon und theta) in die kolorektalen Zelllinie SW480 und die Melanomzellinie D05 transfiziert und exprimiert.rnrnDiese Arbeit wurde erstellt, um die folgenden Ziele zu erreichen. Untersuchung der Rolle von CXCL12 Splicevarianten bei der Vermittlung von Tumorprogression, Adhäsion, Migration, Invasion und Metastasierung von Darmkrebs. Untersuchung, ob die CXCL12 Variantenwege ein wichtiges Ziel für die Entwicklung von Krebstherapien darstellen.rn• Um eine in vivo Mausmodell zu entwickeln, um die Rolle der CXCL12 Varianten im Rahmen des Tumorwachstums zu verstehen.rnrnUnsere Ergebnisse zeigen, dass:Der CXCL12 G801A Polymorphismus ist ein Low-Penetranz Risikofaktor für die Entwicklung von Darmkrebs. Der CXCL12-Gen-Polymorphismus rs1801157 ist mit dem T-Status (Tumor-node-Metastasen) assoziiert. Es gab keine Beziehung zwischen CXCL12-Gen-Polymorphismus rs1801157 und Fernmetastisen oder LN metastasen. Alle sechs CXCL12 Splicevarianten werden im Darmkrebs und in gesunder Kolon mucosa exprimiert. Die höchste Expression wird bei SDF-1alpha, dann SDF-1 beta gefunden. Alle sechs CXCL12 Varianten zeigen erhöhte Tumorzellproliferation in vitro. SDF-1beta, gefolgt von SDF-1alpha zeigte die größte Aktivität im Proliferationsassay.rn• Alle sechs CXCL12 Varianten induzieren die Tumorzelladhäsion.SDF-1beta dann SDF-1alpha zeigte die größte Aktivität im Rahmen des Adhäsionsassay. Alle sechs CXCL12 Varianten erhöhten die Zellmigration und Invasion von Tumorzellen in vitro. SDF-1theta und SDF-1epsilon 1theta zeigten die größte Aktivität, während die schwächste Aktivität mit SDF-1alpha und SDF-1beta beobachtet wurde. Alle sechs CXCL12 Varianten aktivieren Akt und (MAPK) Mitogen- acktivatedierte Protein kinase Wege und damit die Regulierung viele essentieller Prozesse in Tumorzellen, wie Proliferation, Migration, Invasion und Adhäsion. Es ist interessant festzustellen, dass AMD3100 die CXCL12 Splicevarianten inhibriert, die AKT-MEK-1/2-Phosphorylierung induzieren.rnDer Inhibitor AMD3100 unterdrückt stark die CXCL12 Varianten -delta, -epsilon und…

Subjects/Keywords: Biologie; Life sciences

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APA (6^th Edition):

Hussein Allami, R. (2013). Influence of the chemokine CXCL12 on the progression and the signaling in colorectal cancer. (Doctoral Dissertation). Johannes Gutenberg Universität Mainz. Retrieved from http://ubm.opus.hbz-nrw.de/volltexte/2013/3489/

Chicago Manual of Style (16^th Edition):

Hussein Allami, Risala. “Influence of the chemokine CXCL12 on the progression and the signaling in colorectal cancer.” 2013. Doctoral Dissertation, Johannes Gutenberg Universität Mainz. Accessed January 23, 2021. http://ubm.opus.hbz-nrw.de/volltexte/2013/3489/.

MLA Handbook (7^th Edition):

Hussein Allami, Risala. “Influence of the chemokine CXCL12 on the progression and the signaling in colorectal cancer.” 2013. Web. 23 Jan 2021.

Vancouver:

Hussein Allami R. Influence of the chemokine CXCL12 on the progression and the signaling in colorectal cancer. [Internet] [Doctoral dissertation]. Johannes Gutenberg Universität Mainz; 2013. [cited 2021 Jan 23]. Available from: http://ubm.opus.hbz-nrw.de/volltexte/2013/3489/.

Council of Science Editors:

Hussein Allami R. Influence of the chemokine CXCL12 on the progression and the signaling in colorectal cancer. [Doctoral Dissertation]. Johannes Gutenberg Universität Mainz; 2013. Available from: http://ubm.opus.hbz-nrw.de/volltexte/2013/3489/

Universiteit Utrecht

2. Hofman, E.G. Plasma membrane organization during EGFR signaling: a FRET-based analysis.

Degree: 2008, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/30336

► Since two decades it has been suggested that the plasma membrane is organized into lipid-separated domains called lipid rafts. A number of functions have been… (more)

▼ Since two decades it has been suggested that the plasma membrane is organized into lipid-separated domains called lipid rafts. A number of functions have been attributed to these domains, including spatially separating or combining functionally linked proteins. Proteins such as the Epidermal Growth Factor Receptor (EGFR) are found to be localized in membrane domains, as well as effector molecules downstream in the signal transduction cascade. The investigation of these structures has mainly been performed by highly invasive techniques such as biochemical analysis, but lacks data on the situation in intact cells. Chapter 2 of this thesis describes the use of Förster Resonance Energy Transfer (FRET) to study the presence and dynamics of membrane domains containing EGFR. To study this receptor we developed fluorescent nanobodies, monovalent domains from cameloid heavy-chain only antibodies. FRET-FLIM analysis revealed that EGFR resides in a subclass of nanodomains including the ganglioside GM1, and is absent in domains composed of GM1 and GPI-linked GFP. Activation of EGFR results in the coalescence of the two domains, suggesting the formation of signaling platforms. Lipid domains are often suggested to promote the local clustering of their constituents. Therefore, a part of this work describes the development of a novel approach to study the oligomerization state of the domain components in intact cells. This technique, confocal time-resolved fluorescence anisotropy imaging microscopy (CTRFAIM), is based on FRET between identical fluorophores (homo-FRET). The anisotropy, defined as the degree of polarization of the fluorescence, is directly related to the degree of oligomerization. In this thesis, a simplification of this approach is described by applying time-gated data acquisition (chapter 3 and 4). An inducible FKBP dimerization and oligomerization system was developed to correlate the anisotropy value to the oligomerization state. Chapter 4 describes an evaluation of different modes of data acquisition. When compared to steady-state anisotropy, CTR-FAIM shows an improved dynamic range of anisotropy values. A further improvement can be obtained with two-photon excitation, although this improvement is diminished by significant higher photobleaching (chapter 4). When subjected to CTRFAIM analysis, the domain components in our study were indeed found to be clustered. By controlled photobleaching, the lipid raft probe GPI-GFP was found to form small nanoclusters of 1-5 molecules. Also EGFR was found to organize into oligomers, depending on the activation state of the receptor. The CTRFAIM data reveal pre-existing dimers of EGFR in the plasma membrane of resting cells. After stimulation with EGF, the receptor oligomerizes in a kinase- and phosphotyrosine-dependent manner, forming clusters of 3 or more receptors (chapter 5). Furthermore, induced receptor clustering enhances receptor internalization speed, which suggests a stimulatory role for EGFR oligomerization in the internalization process. In conclusion, these data… Advisors/Committee Members: Verkleij, A, van Bergen en Henegouwen, P.

Subjects/Keywords: Molecular biology; Life sciences; Cell biology; Biologie/Milieukunde (BIOL); International (English)

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APA (6^th Edition):

Hofman, E. G. (2008). Plasma membrane organization during EGFR signaling: a FRET-based analysis. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/30336

Chicago Manual of Style (16^th Edition):

Hofman, E G. “Plasma membrane organization during EGFR signaling: a FRET-based analysis.” 2008. Doctoral Dissertation, Universiteit Utrecht. Accessed January 23, 2021. http://dspace.library.uu.nl:8080/handle/1874/30336.

MLA Handbook (7^th Edition):

Hofman, E G. “Plasma membrane organization during EGFR signaling: a FRET-based analysis.” 2008. Web. 23 Jan 2021.

Vancouver:

Hofman EG. Plasma membrane organization during EGFR signaling: a FRET-based analysis. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2008. [cited 2021 Jan 23]. Available from: http://dspace.library.uu.nl:8080/handle/1874/30336.

Council of Science Editors:

Hofman EG. Plasma membrane organization during EGFR signaling: a FRET-based analysis. [Doctoral Dissertation]. Universiteit Utrecht; 2008. Available from: http://dspace.library.uu.nl:8080/handle/1874/30336

Florida International University

3. Rehm, Evan. Factors Affecting Current and Future Treeline Locations and Dynamics in the Peruvian Andes.

Degree: PhD, Biology, 2015, Florida International University

URL: https://digitalcommons.fiu.edu/etd/1836 ; 10.25148/etd.FI15032158 ; FI15032158

► The elevational distributions of tropical treelines are thought to be determined by temperature, and are predicted to shift upslope in response to global warming.… (more)

▼ The elevational distributions of tropical treelines are thought to be determined by temperature, and are predicted to shift upslope in response to global warming. In contrast to this hypothesis, global-scale studies have shown that only half of all studied treelines are shifting upslope. Understanding how treelines will respond to climate change has important implications for global biodiversity, especially in the tropics, because tropical treelines generally represent the upper-elevation distribution limit of the hyper-diverse cloudforest ecosystem. In Chapter 1, I introduce the idea that grasslands found above tropical treelines may represent a potential grass ceiling which forest species cannot cross or invade. I use an extensive literature review to outline potential mechanisms which may be acting to stabilize treeline and prevent forest expansion into high-elevation grasslands. In Chapters 2-4, I begin to explore these potential mechanisms through the use of observational and experimental methods. In Chapter 2, I show that there are significant numbers of seedlings occurring just outside of the treeline in the open grasslands and that seed rain is unlikely to limit seedling recruitment above treeline. I also show that microclimates outside of the closed-canopy cloudforest are highly variable and that mean temperatures are likely a poor explanation of tropical treeline elevations. In Chapter 3, I show that juvenile trees maintain freezing resistances similar to adults, but nighttime radiative cooling near the ground in the open grassland results in lower cold temperatures relative to the free atmosphere, exposing seedlings of some species growing above treeline to lethal frost events. In Chapter 4, I use a large-scale seedling transplant experiment to test the effects of mean temperature, absolute low temperature and shade on transplanted seedling survival. I find that increasing mean temperature negatively affects seedling survival of two treeline species while benefiting another. In addition, low temperature extremes and the presence of shade also appear to be important factors affecting seedling survival above tropical treelines. This work demonstrates that mean temperature is a poor predictor of tropical treelines and that temperature extremes, especially low temperatures, and non-climatic variables should be included in predictions of current and future tropical treeline dynamics. Advisors/Committee Members: Ken Feeley, J. Albert Uy, Steven F. Oberbauer, Hong Liu, John Withey.

Subjects/Keywords: Life sciences; biology; Biology; Life Sciences

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APA (6^th Edition):

Rehm, E. (2015). Factors Affecting Current and Future Treeline Locations and Dynamics in the Peruvian Andes. (Doctoral Dissertation). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/1836 ; 10.25148/etd.FI15032158 ; FI15032158

Chicago Manual of Style (16^th Edition):

Rehm, Evan. “Factors Affecting Current and Future Treeline Locations and Dynamics in the Peruvian Andes.” 2015. Doctoral Dissertation, Florida International University. Accessed January 23, 2021. https://digitalcommons.fiu.edu/etd/1836 ; 10.25148/etd.FI15032158 ; FI15032158.

MLA Handbook (7^th Edition):

Rehm, Evan. “Factors Affecting Current and Future Treeline Locations and Dynamics in the Peruvian Andes.” 2015. Web. 23 Jan 2021.

Vancouver:

Rehm E. Factors Affecting Current and Future Treeline Locations and Dynamics in the Peruvian Andes. [Internet] [Doctoral dissertation]. Florida International University; 2015. [cited 2021 Jan 23]. Available from: https://digitalcommons.fiu.edu/etd/1836 ; 10.25148/etd.FI15032158 ; FI15032158.

Council of Science Editors:

Rehm E. Factors Affecting Current and Future Treeline Locations and Dynamics in the Peruvian Andes. [Doctoral Dissertation]. Florida International University; 2015. Available from: https://digitalcommons.fiu.edu/etd/1836 ; 10.25148/etd.FI15032158 ; FI15032158

Virginia Commonwealth University

4. Krishnan, Priya. THE ABUNDANCE AND INFECTION STATUS OF ANOPHELES spp. MOSQUITOES AT THREE SITES IN LOUDOUN COUNTY, NORTHERN VIRGINIA.

Degree: MS, Biology, 2011, Virginia Commonwealth University

URL: https://doi.org/10.25772/7H2G-P864 ; https://scholarscompass.vcu.edu/etd/319

► Malaria is a re-emerging infectious disease with approximately half of the world's population at risk. In the US, since the 1950’s the Center for Disease… (more)

▼ Malaria is a re-emerging infectious disease with approximately half of the world's population at risk. In the US, since the 1950’s the Center for Disease Control (CDC) has been reporting between 1,000 and 1,500 cases of malaria every year. A majority of these cases were among US travellers and were attributed to Plasmodium falciparum. In August 2002, two cases of human malaria due to Plasmodium vivax were reported in Loudoun County, Northern Virginia. The Center for Disease Control and Prevention concluded that these cases were acquired locally. This was because of an absence of other risk factors such as international travel, and blood transfusion. Pools of Anopheles quadrimaculatus and Anopheles punctipennis collected in Loudoun County, Northern Virginia in 2002 tested positive for P. vivax subtype 210 indicating local transmission of malaria in the area. The purpose of this study is two-fold: 1) to determine the abundance of blood-fed Anopheles mosquitoes in the three sites close to the 2002 local transmission of human malaria in Loudoun County, Northern Virginia, and 2) to determine the infection status of the blood-fed Anopheles mosquitoes collected in the area. We observed a significant difference in the total abundance of Anopheles quadrimaculatus and Anopheles punctipennis at all the three sites, with Anopheles quadrimaculatus being more abundant. We also found a significant difference in the total abundance of Anopheles quadrimaculatus across the years at each of the three sites. All the pools collected in 2009 and 2010 tested negative for human Plasmodium parasites. The pools collected in 2010 tested negative for avian Plasmodium and Haemoproteus parasites. However, in 2009, 20 (28%) pools out of 71 tested positive for avian Plasmodium and Haemoproteus parasites. Four (20%) pools tested positive for avian Plasmodium, three of which were composed of Anopheles quadrimaculatus and were collected at Algonkian Regional Park while, one pool of Anopheles punctipennis was collected at Youngs Cliff. In addition, one (5%) pool composed of Anopheles quadrimaculatus and collected from Algonkian Regional Park tested positive for Haemoproteus. Eleven (55%) pools tested positive for both Haemoproteus and Plasmodium. Of these, four pools were composed of Anopheles quadrimaculatus and were collected from Algonkian Regional Park, two pools composed of Anopheles quadrimaculatus and one pool composed of Anopheles punctipennis were collected from Youngs Cliff. Lastly, four pools collected at Potomac Drive were composed of Anopheles quadrimaculatus. In summary, Algonkian Regional Park showed a high number of mosquitoes with malarial parasites. The maximum likelihood estimation (MLE) of mosquito infection rates based on the Biggerstaff (2006) method showed that among the three sites Youngs cliff had the overall highest infection rate (74.50%) for Anopheles mosquitoes compared to Algonkian Regional Park (53.86%) and Potomac drive (25.01%). An. quadrimaculatus had a higher infection rate compared at Algonkian… Advisors/Committee Members: Ghislaine Mayer.

Subjects/Keywords: Biology; Life Sciences

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APA (6^th Edition):

Krishnan, P. (2011). THE ABUNDANCE AND INFECTION STATUS OF ANOPHELES spp. MOSQUITOES AT THREE SITES IN LOUDOUN COUNTY, NORTHERN VIRGINIA. (Thesis). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/7H2G-P864 ; https://scholarscompass.vcu.edu/etd/319

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Krishnan, Priya. “THE ABUNDANCE AND INFECTION STATUS OF ANOPHELES spp. MOSQUITOES AT THREE SITES IN LOUDOUN COUNTY, NORTHERN VIRGINIA.” 2011. Thesis, Virginia Commonwealth University. Accessed January 23, 2021. https://doi.org/10.25772/7H2G-P864 ; https://scholarscompass.vcu.edu/etd/319.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Krishnan, Priya. “THE ABUNDANCE AND INFECTION STATUS OF ANOPHELES spp. MOSQUITOES AT THREE SITES IN LOUDOUN COUNTY, NORTHERN VIRGINIA.” 2011. Web. 23 Jan 2021.

Vancouver:

Krishnan P. THE ABUNDANCE AND INFECTION STATUS OF ANOPHELES spp. MOSQUITOES AT THREE SITES IN LOUDOUN COUNTY, NORTHERN VIRGINIA. [Internet] [Thesis]. Virginia Commonwealth University; 2011. [cited 2021 Jan 23]. Available from: https://doi.org/10.25772/7H2G-P864 ; https://scholarscompass.vcu.edu/etd/319.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Krishnan P. THE ABUNDANCE AND INFECTION STATUS OF ANOPHELES spp. MOSQUITOES AT THREE SITES IN LOUDOUN COUNTY, NORTHERN VIRGINIA. [Thesis]. Virginia Commonwealth University; 2011. Available from: https://doi.org/10.25772/7H2G-P864 ; https://scholarscompass.vcu.edu/etd/319

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Commonwealth University

5. Runnels, Cora. Phylogeography and Species Status of Ramphogordius sanguineus.

Degree: MS, Biology, 2013, Virginia Commonwealth University

URL: https://doi.org/10.25772/EXFP-RG83 ; https://scholarscompass.vcu.edu/etd/3165

► Ramphogordius sanguineus (Rathke 1799) is a gregarious nemertean with a worldwide distribution and found mainly on hard substrates associated with mussels, oysters and other organisms… (more)

Subjects/Keywords: Biology; Life Sciences

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APA (6^th Edition):

Runnels, C. (2013). Phylogeography and Species Status of Ramphogordius sanguineus. (Thesis). Virginia Commonwealth University. Retrieved from https://doi.org/10.25772/EXFP-RG83 ; https://scholarscompass.vcu.edu/etd/3165

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Runnels, Cora. “Phylogeography and Species Status of Ramphogordius sanguineus.” 2013. Thesis, Virginia Commonwealth University. Accessed January 23, 2021. https://doi.org/10.25772/EXFP-RG83 ; https://scholarscompass.vcu.edu/etd/3165.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Runnels, Cora. “Phylogeography and Species Status of Ramphogordius sanguineus.” 2013. Web. 23 Jan 2021.

Vancouver:

Runnels C. Phylogeography and Species Status of Ramphogordius sanguineus. [Internet] [Thesis]. Virginia Commonwealth University; 2013. [cited 2021 Jan 23]. Available from: https://doi.org/10.25772/EXFP-RG83 ; https://scholarscompass.vcu.edu/etd/3165.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Runnels C. Phylogeography and Species Status of Ramphogordius sanguineus. [Thesis]. Virginia Commonwealth University; 2013. Available from: https://doi.org/10.25772/EXFP-RG83 ; https://scholarscompass.vcu.edu/etd/3165

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Southern Mississippi

6. Lain, Emily Johanna. Effects of Hurricane Disturbance on the Stopover Ecology of Intercontinental Landbird Migrants in Coastal Louisiana.

Degree: MS, Biological Sciences, 2012, University of Southern Mississippi

URL: https://aquila.usm.edu/masters_theses/383

► Few studies have considered the impact of weather events on migratory birds during stopover, and essentially none on how hurricanes affect their stopover biology… (more)

▼ Few studies have considered the impact of weather events on migratory birds during stopover, and essentially none on how hurricanes affect their stopover biology during spring passage. About two thirds of eastern North American forest breeding bird species migrate twice annually between temperate breeding areas and subtropical and tropical wintering grounds, and movement in relation to the Gulf of Mexico (GOM) is a conspicuous and important part of that migration system. During inclement weather or winds inconsistent with travel direction, migratory birds oft.en/a/lout and concentrate by the thousands in forest patches that occur along the northern coast of the GOM. Anthropogenic change, hurricanes, sea level rise, and coastal subsidence have greatly reduced the amount of coastal forest in this region, which may affect the stopover biology of migratory birds. In southwestern Louisiana, coastal cheniere forests are the first possible landfall for birds returning north in spring after a nonstop flight (18-24 hr) of greater than 1,000 km. Since chenieres serve as important stopover sites for migratory birds, disturbances that alter them may affect the ability of migrants to replenish important fuel stores to continue migration. This region was severely impacted by two recent hurricanes, Rita in 2005 and Ike in 2008. For this thesis I assess the impact of these storms on spring migrants at two levels: (1) abundance of birds with similar foraging strategies (i.e. foraging guilds) and (2) stopover biology, including fuel deposition rates, of individual migrants. To do so I utilize long-term data collected on migratory birds at a study site near Johnson Bayou, which was directly impacted by both storms. Species were classified into foraging guilds based on the vertical height (i.e. canopy/subcanopy, understory, and ground) and foraging substrate (e.g. live foliage, leaf litter) where birds were typically observed in chenieres during spring migration. Bird mist net capture data, avian transect data, and vegetation survey data collected pre- and post-hurricane were examined for changes in response to storm damage to stopover habitat. Capture data were also used to assess whether stopover duration (SD) and fuel deposition rate (FDR) differed pre- and post-storm for species representatives from different foraging guilds. Live foliage-gleaning canopy foragers decreased post-storm compared to pre-storm levels yet canopy airspace foragers increased after each storm, significantly after Hurricane Ike (p<0.01). Arthropod-foraging understory species decreased with each storm and frugivorous understory species increased after Hurricane Rita. Ground foraging species that feed in open, grassy areas increased, whereas leaflitter foraging species decreased. Although both storms had major impacts on vegetative structure, SD and FDR did not differ in line with guild-specific storm-response expectations. Migrant abundance by guild pre- and post-storm changed as expected, but in most cases the differences were not consistent across all… Advisors/Committee Members: Frank Moore, Wylie Barrow, Wylie Barrow.

Subjects/Keywords: Biology; Life Sciences

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APA (6^th Edition):

Lain, E. J. (2012). Effects of Hurricane Disturbance on the Stopover Ecology of Intercontinental Landbird Migrants in Coastal Louisiana. (Masters Thesis). University of Southern Mississippi. Retrieved from https://aquila.usm.edu/masters_theses/383

Chicago Manual of Style (16^th Edition):

Lain, Emily Johanna. “Effects of Hurricane Disturbance on the Stopover Ecology of Intercontinental Landbird Migrants in Coastal Louisiana.” 2012. Masters Thesis, University of Southern Mississippi. Accessed January 23, 2021. https://aquila.usm.edu/masters_theses/383.

MLA Handbook (7^th Edition):

Lain, Emily Johanna. “Effects of Hurricane Disturbance on the Stopover Ecology of Intercontinental Landbird Migrants in Coastal Louisiana.” 2012. Web. 23 Jan 2021.

Vancouver:

Lain EJ. Effects of Hurricane Disturbance on the Stopover Ecology of Intercontinental Landbird Migrants in Coastal Louisiana. [Internet] [Masters thesis]. University of Southern Mississippi; 2012. [cited 2021 Jan 23]. Available from: https://aquila.usm.edu/masters_theses/383.

Council of Science Editors:

Lain EJ. Effects of Hurricane Disturbance on the Stopover Ecology of Intercontinental Landbird Migrants in Coastal Louisiana. [Masters Thesis]. University of Southern Mississippi; 2012. Available from: https://aquila.usm.edu/masters_theses/383

University of Southern Mississippi

7. Teng, Chengwen. Immunostimulatory and Cellular Toxic Effects of Single-Stranded RNA On Cancer Cells.

Degree: MS, Biological Sciences, 2012, University of Southern Mississippi

URL: https://aquila.usm.edu/masters_theses/564

► Whether 5'-triphosphate-single-stranded-RNA (5 '-ppp-ssRNA) is immunostimulatory was controversial in the literature. In order to clarify the immunostimulatory effect of 5'-ppp-ssRNA, we synthesized ssRNAs and… (more)

Subjects/Keywords: Biology; Life Sciences

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APA (6^th Edition):

Teng, C. (2012). Immunostimulatory and Cellular Toxic Effects of Single-Stranded RNA On Cancer Cells. (Masters Thesis). University of Southern Mississippi. Retrieved from https://aquila.usm.edu/masters_theses/564

Chicago Manual of Style (16^th Edition):

Teng, Chengwen. “Immunostimulatory and Cellular Toxic Effects of Single-Stranded RNA On Cancer Cells.” 2012. Masters Thesis, University of Southern Mississippi. Accessed January 23, 2021. https://aquila.usm.edu/masters_theses/564.

MLA Handbook (7^th Edition):

Teng, Chengwen. “Immunostimulatory and Cellular Toxic Effects of Single-Stranded RNA On Cancer Cells.” 2012. Web. 23 Jan 2021.

Vancouver:

Teng C. Immunostimulatory and Cellular Toxic Effects of Single-Stranded RNA On Cancer Cells. [Internet] [Masters thesis]. University of Southern Mississippi; 2012. [cited 2021 Jan 23]. Available from: https://aquila.usm.edu/masters_theses/564.

Council of Science Editors:

Teng C. Immunostimulatory and Cellular Toxic Effects of Single-Stranded RNA On Cancer Cells. [Masters Thesis]. University of Southern Mississippi; 2012. Available from: https://aquila.usm.edu/masters_theses/564

University of Southern Mississippi

8. Wang, Jundi. Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells.

Degree: MS, Biological Sciences, 2013, University of Southern Mississippi

URL: https://aquila.usm.edu/masters_theses/572

► Embryonic stem cells (ESCs) are cells that have unlimited capacity for selfrenewal and differentiation. These properties make ESCs a great cell source for application… (more)

Subjects/Keywords: Biology; Life Sciences

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APA (6^th Edition):

Wang, J. (2013). Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells. (Masters Thesis). University of Southern Mississippi. Retrieved from https://aquila.usm.edu/masters_theses/572

Chicago Manual of Style (16^th Edition):

Wang, Jundi. “Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells.” 2013. Masters Thesis, University of Southern Mississippi. Accessed January 23, 2021. https://aquila.usm.edu/masters_theses/572.

MLA Handbook (7^th Edition):

Wang, Jundi. “Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells.” 2013. Web. 23 Jan 2021.

Vancouver:

Wang J. Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells. [Internet] [Masters thesis]. University of Southern Mississippi; 2013. [cited 2021 Jan 23]. Available from: https://aquila.usm.edu/masters_theses/572.

Council of Science Editors:

Wang J. Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells. [Masters Thesis]. University of Southern Mississippi; 2013. Available from: https://aquila.usm.edu/masters_theses/572

University of Southern Mississippi

9. Sellers, Johnny Michael. Tick Infestations and Their Consequences for Migratory Songbirds During Spring Stopover.

Degree: MS, Biological Sciences, 2011, University of Southern Mississippi

URL: https://aquila.usm.edu/masters_theses/554

► Migratory birds face a number of challenges during their seasonal movement from tropical/sub-tropical Central and South America to more temperate North America. Maintaining health… (more)

Subjects/Keywords: Biology; Life Sciences

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APA (6^th Edition):

Sellers, J. M. (2011). Tick Infestations and Their Consequences for Migratory Songbirds During Spring Stopover. (Masters Thesis). University of Southern Mississippi. Retrieved from https://aquila.usm.edu/masters_theses/554

Chicago Manual of Style (16^th Edition):

Sellers, Johnny Michael. “Tick Infestations and Their Consequences for Migratory Songbirds During Spring Stopover.” 2011. Masters Thesis, University of Southern Mississippi. Accessed January 23, 2021. https://aquila.usm.edu/masters_theses/554.

MLA Handbook (7^th Edition):

Sellers, Johnny Michael. “Tick Infestations and Their Consequences for Migratory Songbirds During Spring Stopover.” 2011. Web. 23 Jan 2021.

Vancouver:

Sellers JM. Tick Infestations and Their Consequences for Migratory Songbirds During Spring Stopover. [Internet] [Masters thesis]. University of Southern Mississippi; 2011. [cited 2021 Jan 23]. Available from: https://aquila.usm.edu/masters_theses/554.

Council of Science Editors:

Sellers JM. Tick Infestations and Their Consequences for Migratory Songbirds During Spring Stopover. [Masters Thesis]. University of Southern Mississippi; 2011. Available from: https://aquila.usm.edu/masters_theses/554

University of Southern Mississippi

10. Salamone, Amy Leigh. Fungal Biofilm Colonization and Succession on Artificial Reefs in the North-Central Gulf of Mexico.

Degree: MS, Coastal Sciences, Gulf Coast Research Laboratory, 2012, University of Southern Mississippi

URL: https://aquila.usm.edu/masters_theses/548

► This study represents the first characterization of natural mixed-species fungal biofilm communities on artificial reefs in the marine environment. Previous fungal biofilm studies have… (more)

▼ This study represents the first characterization of natural mixed-species fungal biofilm communities on artificial reefs in the marine environment. Previous fungal biofilm studies have failed to observe the naturally-occurring biodiversity in coastal areas, which comprise the most utilized zone of the marine environment. Artificial reefs can increase fishing yields, amplify oyster habitats, contribute to shoreline stabilization, promote good water quality, and deter pollution. Proper management practices of artificial reefs require knowledge of the colonization of these new habitats by marine organisms and their subsequent succession. Fungi, along with bacteria, archaea, protists, algae, and diatoms, quickly form a complex biofilm on immersed surfaces in seawater. These communities fuel many primary consumers that support artificial reef habitats. Patterns of settlement and succession should be further examined, given the major trophic implications therein, as properties of this biofilm will influence future establishment of other marine organisms. Four created artificial reefs in the Mississippi Sound representing low profile (submerged) and high profile (emergent) conditions were sampled quarterly to characterize biofilm fungal communities. Biofilm samples were analyzed to determine fungal presence by amplifying the internal transcribed spacer (ITS) region of fungal ribosomal DNA. Terminal fragment length polymorphism (T-RFLP) analysis of the ITS region was used to infer variation in fungal community structure. Fungal species were further characterized by performing morphological species identification as well as ITS gene sequencing. Significant temporal and longitudinal differences in fungal biofilm communities, as well as a weaker difference between high and low profile reef types, were detected during this study. Furthermore, the high profile reefs, Handkerchief and Katrina, were significantly different in fungal biofilm community composition between reefs across the ten sampling periods. This assessment of fungal biofilm communities yields insight into the development of artificial reef microbial succession, diversity, and function. Advisors/Committee Members: Jay Grimes, Chet Rakocinski, Kevin Dillon.

Subjects/Keywords: Biology; Life Sciences

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APA (6^th Edition):

Salamone, A. L. (2012). Fungal Biofilm Colonization and Succession on Artificial Reefs in the North-Central Gulf of Mexico. (Masters Thesis). University of Southern Mississippi. Retrieved from https://aquila.usm.edu/masters_theses/548

Chicago Manual of Style (16^th Edition):

Salamone, Amy Leigh. “Fungal Biofilm Colonization and Succession on Artificial Reefs in the North-Central Gulf of Mexico.” 2012. Masters Thesis, University of Southern Mississippi. Accessed January 23, 2021. https://aquila.usm.edu/masters_theses/548.

MLA Handbook (7^th Edition):

Salamone, Amy Leigh. “Fungal Biofilm Colonization and Succession on Artificial Reefs in the North-Central Gulf of Mexico.” 2012. Web. 23 Jan 2021.

Vancouver:

Salamone AL. Fungal Biofilm Colonization and Succession on Artificial Reefs in the North-Central Gulf of Mexico. [Internet] [Masters thesis]. University of Southern Mississippi; 2012. [cited 2021 Jan 23]. Available from: https://aquila.usm.edu/masters_theses/548.

Council of Science Editors:

Salamone AL. Fungal Biofilm Colonization and Succession on Artificial Reefs in the North-Central Gulf of Mexico. [Masters Thesis]. University of Southern Mississippi; 2012. Available from: https://aquila.usm.edu/masters_theses/548

University of Southern Mississippi

11. Skiff, Jeffrey Jay. Interactions Between Protozoan Prey (Phylum protista) and Their Mosquito Predators (Order Diptera, Family Cuclicidae) Prey Size and Predator Behavior Effects.

Degree: MS, Biological Sciences, 2013, University of Southern Mississippi

URL: https://aquila.usm.edu/masters_theses/556

► Mosquitoes (Diptera. Culicidae) are insects that are medically important as adults as they vector numerous diseases. Yet, understanding the ecology of the larval stage… (more)

▼ Mosquitoes (Diptera. Culicidae) are insects that are medically important as adults as they vector numerous diseases. Yet, understanding the ecology of the larval stage can lead to surveillance and control of adult populations. Aedes albopictus, Aedes triseriatus, Cu/ex corona/or, and Culex quinquefasciatus are four species of mosquito that co-occur in discarded automobile tires. Mosqui-to larvae feed on microorganisms (including protozoans) and particulate organic matter Most larval feeding experiments. howt:ver, have dealt exclusively with bacteria, fungi , and particulate organic matter Although bactena and fungi are important sources of nitrogen and lipids, they may be 111sufficient sources of carbon, which may be supplied by protozoans. The importance of protozoans to mosquitoes is not fully understood. I investigated the interactions between protozoans and mosquitoes based on predator behavior and size selection. I investigated the effect protozoans had when added with bacteria on mosquito larvae performance compared to bacteria alone. There were no siginificant differences for either species in survival. development time, or adult mass between mosquitoes that were fed protozoans or not. I investigated differences m larval behavior between four species of mosquito larvae. Differences m feeding behaviors were significantly greater between genera than within genera, but Culex corona/or shared similar non-feeding behaviors as the two Aedes species. [ investigated the differences in larval survival and mean instar in the presence of three genera of protozoans (Paramecium, Blepharisma, and Colpidium) that represented two size classes. There were no significant differences in survival or mean instar between the seven prey combinations for either species, and the mosquito larvae did not seem to have a preference for one of the prey combinations over the others. My results show that protozoans do not seem to add any value to mosquito larvae, but protozoans may be more important to mosquitoes than just survival, mass, or development time. Advisors/Committee Members: Donald Yee, Jake Schaefer, Jodie Jawor.

Subjects/Keywords: Biology; Life Sciences

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APA (6^th Edition):

Skiff, J. J. (2013). Interactions Between Protozoan Prey (Phylum protista) and Their Mosquito Predators (Order Diptera, Family Cuclicidae) Prey Size and Predator Behavior Effects. (Masters Thesis). University of Southern Mississippi. Retrieved from https://aquila.usm.edu/masters_theses/556

Chicago Manual of Style (16^th Edition):

Skiff, Jeffrey Jay. “Interactions Between Protozoan Prey (Phylum protista) and Their Mosquito Predators (Order Diptera, Family Cuclicidae) Prey Size and Predator Behavior Effects.” 2013. Masters Thesis, University of Southern Mississippi. Accessed January 23, 2021. https://aquila.usm.edu/masters_theses/556.

MLA Handbook (7^th Edition):

Skiff, Jeffrey Jay. “Interactions Between Protozoan Prey (Phylum protista) and Their Mosquito Predators (Order Diptera, Family Cuclicidae) Prey Size and Predator Behavior Effects.” 2013. Web. 23 Jan 2021.

Vancouver:

Skiff JJ. Interactions Between Protozoan Prey (Phylum protista) and Their Mosquito Predators (Order Diptera, Family Cuclicidae) Prey Size and Predator Behavior Effects. [Internet] [Masters thesis]. University of Southern Mississippi; 2013. [cited 2021 Jan 23]. Available from: https://aquila.usm.edu/masters_theses/556.

Council of Science Editors:

Skiff JJ. Interactions Between Protozoan Prey (Phylum protista) and Their Mosquito Predators (Order Diptera, Family Cuclicidae) Prey Size and Predator Behavior Effects. [Masters Thesis]. University of Southern Mississippi; 2013. Available from: https://aquila.usm.edu/masters_theses/556

Florida State University

12. Grise, Henry. Identification and Characterization of Tandem Cyclophilin a Binding Sites in Non-Structural Protein 5A.

Degree: PhD, Biological Science, 2011, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7151 ;

►

Hepatitis C virus (HCV) is an enveloped RNA virus that often manifests into chronic infections of the liver, which represents a threat to human health… (more)

▼

Hepatitis C virus (HCV) is an enveloped RNA virus that often manifests into chronic infections of the liver, which represents a threat to human health due to the morbidity it presents within infected patients. The virus is especially persistent as current antiviral treatments have difficulty in restricting the infections, allowing most new cases of viral hepatitis to develop into persistent infections. It has emerged as a major causative agent of liver diseases, resulting in cirrhosis, liver failure, and hepatocellular carcinoma as the disease progresses with time. There is no prophylactic vaccine currently available to protect against HCV, nor is there an effective therapy capable of generating a sustained virologic response. HCV has shown the capability of developing resistance to antiviral compounds that target specific viral enzymes necessary for replication. HCV is found as quasispecies within an individual due to its error prone RNA-dependent RNA polymerase. The genetic heterogeneity of HCV allows it to be capable of escaping the effect of compounds that specifically target viral proteins. Several cellular cofactors have been identified recently that permit HCV to be infectious. The interactions of these cofactors with viral proteins shed light on the life cycle of HCV and warrant further study as potential cellular targets to restrict viral infectivity. One such cofactor is cyclophilin A (CyPA) which has peptidylproline isomerase (PPIase) activity. HCV strains with a reduced dependency on CyPA for replication were selected in a CyPA-knockdown cell line. Sequencing of these isolates revealed mutations within a dipeptide motif of domain 2 of NS5A for all clones (D316E and/or Y317N). Analysis of these phenotypes upon insertion into the full-length viral genome revealed the double mutant, termed DEYN, to most efficiently restore the infectivity of the virus in CyPA-knockdown cells to that of control cells. We have hypothesized several possible mechanisms for the reduced dependency on CyPA of DEYN virus. These mutations could potentially affect viral replication via the PPIase activity of CyPA which catalyzes the cis-trans isomerization of proline residues. Presumably, HCV requires CyPA as a host cofactor to isomerize one or more proline residues within NS5A, converting it from a non-functional, unfolded protein into a functional, folded conformer. The work described here identifies structural differences between wt and mutant NS5A sequences, identifies CyPA binding sites within domain II and LCS II, and describes critical determinants within CyPA and NS5A that permit their interactions. Furthermore, this work identified AphiPXW and [AP]LPP as CyPA binding motifs among the 7 genotypes tested.

A Dissertation submitted to the Department of Biological Science in partial fulfillment of the requirements for the degree of Doctorate of Philosophy.

Summer Semester, 2011.

June 14, 2011.

Hengli Tang, Professor Directing Dissertation; Kenneth Roux, Professor Co-Directing Dissertation; Timothy Logan,…

Advisors/Committee Members: Hengli Tang (professor directing dissertation), Kenneth Roux (professor co-directing dissertation), Timothy Logan (university representative), Fanxiu Zhu (committee member).

Subjects/Keywords: Biology; Life sciences

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APA (6^th Edition):

Grise, H. (2011). Identification and Characterization of Tandem Cyclophilin a Binding Sites in Non-Structural Protein 5A. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-7151 ;

Chicago Manual of Style (16^th Edition):

Grise, Henry. “Identification and Characterization of Tandem Cyclophilin a Binding Sites in Non-Structural Protein 5A.” 2011. Doctoral Dissertation, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-7151 ;.

MLA Handbook (7^th Edition):

Grise, Henry. “Identification and Characterization of Tandem Cyclophilin a Binding Sites in Non-Structural Protein 5A.” 2011. Web. 23 Jan 2021.

Vancouver:

Grise H. Identification and Characterization of Tandem Cyclophilin a Binding Sites in Non-Structural Protein 5A. [Internet] [Doctoral dissertation]. Florida State University; 2011. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7151 ;.

Council of Science Editors:

Grise H. Identification and Characterization of Tandem Cyclophilin a Binding Sites in Non-Structural Protein 5A. [Doctoral Dissertation]. Florida State University; 2011. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7151 ;

Florida State University

13. Gignac, Paul Michael. Biomechanics and the Ontogeny of Feeding in the American Alligator (Alligator Mississippiensis): Reconciling Factors Contributing to Intraspecific Niche Differentiation in a Large Bodied Vertebrate.

Degree: PhD, Biological Science, 2010, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7143 ;

► As vertebrates attain a larger body size, the relative growth of various body parts results in differential rates of growth across the organism and may… (more)

▼ As vertebrates attain a larger body size, the relative growth of various body parts results in differential rates of growth across the organism and may result in substantial impacts on mechanical performance. To deal with this problem, shape changes often accompany somatic growth, and the nature of these changes is thought to reflect a tight relationship between the morphological form of an organism's anatomy and its function within a given environment. In this context, the feeding anatomy of vertebrates is a consummate form-function relationship. An extreme example of a taxon that undergoes ontogenetic dietary shifts is the American alligator, Alligator mississippiensis, which traverses a 5000-fold increase in mass during its lifetime. As a consequence, this species must cope with changes in its feeding functional morphology (i.e., size and shape of dental and musculoskeletal attributes) while exploiting varying ecological feeding niches. Hatchlings start out as insectivorous neonates but abandon that feeding niche as larger body size allows them access to a wider range of prey items, first frogs and fish and other small, compliant prey before finally reaching the adult ecomorphology where they access more robust quarry. Absolute body size and bite-force positive allometry play an important role in these transitions. Therefore, to understand the nature of the anatomical changes that underpin these factors and thus facilitate dietary niche transitions, I dissected a growth series of wild A. mississippiensis. I standardized the topology, attachment points, and naming scheme for the jaw adductor musculature and quantified the growth of the cranial skeleton, jaw adductor muscle system, and dental form throughout ontogeny. I derived mathematical models of bite-force and hold-force generation based on these data, and tested them against additional developmental series of known bite-force A. mississippiensis. I developed and implemented a novel technique to identify the aerobic capacity of the jaw adductor muscles, called Muscle Oxidative Inference Analysis (MOIA). Finally, dental pressures were quantified using bite forces and dental morphology. These data demonstrate that after hatching, larger body size (25 cm snout-vent length, SVL) initially allows A. mississippiensis access to increasingly larger, compliant prey. At 45 cm SVL positive allometry in the post-orbital growth of the skull and M. Pterygoideus ventralis muscles in addition to substantial changes in the aerobic capacity of some jaw adductor muscles facilitates access elusive terrestrial prey such as birds and small mammals. By 75 cm SVL, subtle changes in dental form along with bite-force positive allometry make it possible for this taxon to generate tooth pressures that can fracture and mechanically fail the bony carapaces of turtles. Finally, large adult body size (150+ cm SVL) and continued positive allometry in the musculoskeletal attributes of its jaw adductor system and further augmented oxidative capacity of its adductor muscles allow A.… Advisors/Committee Members: Gregory Erickson (professor directing dissertation), William Parker (university representative), P. Bryant Chase (committee member), Brian Inouye (committee member), Emily DuVal (committee member), Patrick Hollis (committee member).

Subjects/Keywords: Biology; Life sciences

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APA (6^th Edition):

Gignac, P. M. (2010). Biomechanics and the Ontogeny of Feeding in the American Alligator (Alligator Mississippiensis): Reconciling Factors Contributing to Intraspecific Niche Differentiation in a Large Bodied Vertebrate. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-7143 ;

Chicago Manual of Style (16^th Edition):

Gignac, Paul Michael. “Biomechanics and the Ontogeny of Feeding in the American Alligator (Alligator Mississippiensis): Reconciling Factors Contributing to Intraspecific Niche Differentiation in a Large Bodied Vertebrate.” 2010. Doctoral Dissertation, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-7143 ;.

MLA Handbook (7^th Edition):

Gignac, Paul Michael. “Biomechanics and the Ontogeny of Feeding in the American Alligator (Alligator Mississippiensis): Reconciling Factors Contributing to Intraspecific Niche Differentiation in a Large Bodied Vertebrate.” 2010. Web. 23 Jan 2021.

Vancouver:

Gignac PM. Biomechanics and the Ontogeny of Feeding in the American Alligator (Alligator Mississippiensis): Reconciling Factors Contributing to Intraspecific Niche Differentiation in a Large Bodied Vertebrate. [Internet] [Doctoral dissertation]. Florida State University; 2010. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7143 ;.

Council of Science Editors:

Gignac PM. Biomechanics and the Ontogeny of Feeding in the American Alligator (Alligator Mississippiensis): Reconciling Factors Contributing to Intraspecific Niche Differentiation in a Large Bodied Vertebrate. [Doctoral Dissertation]. Florida State University; 2010. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7143 ;

Florida State University

14. Hess, Charles A. Restoration of Longleaf Pine in Slash Pine Plantations: Using Fire to Avoid the Landscape Trap.

Degree: PhD, Biological Science, 2014, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-9005 ;

► Upland forests in the southeastern United States (U.S.) were once dominated by the pyrogenic longleaf pine (Pinus palustris)-bunchgrass ecosystem that extended south from Virginia to… (more)

▼ Upland forests in the southeastern United States (U.S.) were once dominated by the pyrogenic longleaf pine (Pinus palustris)-bunchgrass ecosystem that extended south from Virginia to Florida and west to East Texas. Historical land management has reduced the dominance of this ecosystem and today it occupies less than 3% of its original range. Restoration of the longleaf pine-bunchgrass ecosystem in the mesic flatwoods along the Gulf Coastal Plain of the southeastern U.S. has become a common habitat-recovery goal of public land managers, including those responsible for the Apalachicola National Forest (ANF). This research project explores potential techniques to accomplish this goal. There are three objectives: (1) to document changes in the extent of the longleaf pine-bunchgrass ecosystem in transition zones between the pine uplands and the hardwood wetlands of the ANF; (2) to test the importance of canopy retention in the transmission of fire across the landscape during conversion from slash pine (Pinus elliottii) plantations to longleaf pine forest; and (3) to test whether slash pine plantations can be successfully interplanted with longleaf pine seedlings. Overall, the study involved interactions between longleaf pine and fire in the ANF of northern Florida. Without frequent fire, the longleaf ecosystem can enter into what Lindenmayer et al. (2011) call, a "landscape trap," where ecological processes can no longer maintain the original forest type. A comparison of recent and old (1937) aerial photographs reveal that 32,000 hectares [ha] (80,000 acres [ac]) of the wet, grassy flats on the edges of the pine flatwoods have been invaded by shrubs, to become a shrub-dominated community. These shrubs, which are mostly titi (Cyrilla racemiflora and Cliftonia monophylla), have expanded primarily in sites with a greater than three-year fire-return interval. Restoration of the longleaf pine-bunchgrass ecosystem appears to need a <3-year fire-return interval if the processes favoring bunch grasses in the ground cover are to be maintained. For decades, forest managers in the southeastern U.S. have replaced natural longleaf pine communities with high-production slash pine plantations. I contend that restoration of longleaf pine in slash pine plantations will require retention of a fraction of the current slash pine canopy to produce enough needle cast to carry ground fire through the stand. In cooperation with the U.S. Forest Service, I monitored the results of 3 timber treatments in slash pine plantations. These experiments found that removal of the canopy reduces fire transmission. When all canopy trees were experimentally removed, only 12% of the landscape burned; whereas, 80% burned with only 33% canopy reduction. On the forest floor, partial retention of the slash pine canopy contributed ecological attributes similar to a longleaf canopy by promoting frequent low-intensity fires and creating ground cover conditions favoring herbaceous species. Where ground cover was primarily herbaceous, mortality of longleaf seedlings… Advisors/Committee Members: Walter R. Tschinkel (professor directing dissertation), Tingting Zhao (university representative), Frances C. James (committee member), Thomas E. Miller (committee member), Austin R. Mast (committee member).

Subjects/Keywords: Biology; Life sciences

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APA (6^th Edition):

Hess, C. A. (2014). Restoration of Longleaf Pine in Slash Pine Plantations: Using Fire to Avoid the Landscape Trap. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-9005 ;

Chicago Manual of Style (16^th Edition):

Hess, Charles A. “Restoration of Longleaf Pine in Slash Pine Plantations: Using Fire to Avoid the Landscape Trap.” 2014. Doctoral Dissertation, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-9005 ;.

MLA Handbook (7^th Edition):

Hess, Charles A. “Restoration of Longleaf Pine in Slash Pine Plantations: Using Fire to Avoid the Landscape Trap.” 2014. Web. 23 Jan 2021.

Vancouver:

Hess CA. Restoration of Longleaf Pine in Slash Pine Plantations: Using Fire to Avoid the Landscape Trap. [Internet] [Doctoral dissertation]. Florida State University; 2014. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-9005 ;.

Council of Science Editors:

Hess CA. Restoration of Longleaf Pine in Slash Pine Plantations: Using Fire to Avoid the Landscape Trap. [Doctoral Dissertation]. Florida State University; 2014. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-9005 ;

Florida State University

15. Peterson, Cheston Thomas. Distribution and Abundance, Community Structure, and Trophic Ecology of Sharks and Teleost Fishes in the Florida Big Bend.

Degree: MS, Biological Science, 2014, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8868 ;

►

Community structure and trophic ecology of sharks and large teleost fishes in seagrass beds of the Florida Big Bend were investigated using fishery-independent longline and… (more)

▼

Community structure and trophic ecology of sharks and large teleost fishes in seagrass beds of the Florida Big Bend were investigated using fishery-independent longline and gillnet surveys and stable isotope analyses. The Big Bend is inhabited by at least 14 species of elasmobranch and 56 species of teleost fishes during the summer. Assemblages of these fauna are spatially variable, and five species dominate. Community structure was analyzed using a combination of cluster analysis, indicator species analysis, and non-metric multidimensional scaling (NMDS). These analyses suggested community composition of fishes in the Big Bend is correlated with water clarity, salinity, and depth. Patterns of inshore and offshore species assemblages were common throughout the Big Bend. There were two distinct faunal zones: one in the central Big Bend characterized by high relative abundance of blacktip sharks (Carcharhinus limbatus) in turbid water with moderate salinity, and a second in the southern Big Bend characterized by high relative abundance of blacknose sharks (Carcharhinus acronotus) in water of high clarity and salinity. High catch rates of young-of-the-year and juvenile blacktip and blacknose sharks in these areas suggest the central and southern Big Bend may act as nursery habitat for these two species, respectively. Carbon and nitrogen stable isotope analyses were used to infer relative trophic structure of these taxa and the potential for regional variation in trophic patterns. Stable isotope analyses suggest this system is trophically diverse, with considerable isotopic overlap across many taxa. These fishes appear to be supported through multiple channels of primary production potentially dominated by epiphytic microalgae and/or macroalgae. Isotopic ontogenetic were not evident in dominant taxa, with exception to weak relationships of stable isotopes and length in two species of marine catfishes. Comparisons of regional stable isotope values of the dominant species suggest the southern Big Bend is isotopically distinct in terms of the balance of primary production and trophic structure. The results of this study suggest an ecological gradient in the Big Bend, culminating in a distinct southern faunal zone; and based on the results of this work I hypothesize patterns of community composition and trophic structure in the Florida Big Bend are related to varying levels of river influence across the habitat.

A Thesis submitted to the Department of Biological Science in partial fulfillment of the requirements for the degree of Master of Science.

Spring Semester, 2014.

April 2, 2014.

Joe Travis, Committee Member; Walter Tschinkel, Committee Member.

Advisors/Committee Members: Joe Travis (committee member), Walter Tschinkel (committee member).

Subjects/Keywords: Biology; Life sciences

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APA (6^th Edition):

Peterson, C. T. (2014). Distribution and Abundance, Community Structure, and Trophic Ecology of Sharks and Teleost Fishes in the Florida Big Bend. (Masters Thesis). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-8868 ;

Chicago Manual of Style (16^th Edition):

Peterson, Cheston Thomas. “Distribution and Abundance, Community Structure, and Trophic Ecology of Sharks and Teleost Fishes in the Florida Big Bend.” 2014. Masters Thesis, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-8868 ;.

MLA Handbook (7^th Edition):

Peterson, Cheston Thomas. “Distribution and Abundance, Community Structure, and Trophic Ecology of Sharks and Teleost Fishes in the Florida Big Bend.” 2014. Web. 23 Jan 2021.

Vancouver:

Peterson CT. Distribution and Abundance, Community Structure, and Trophic Ecology of Sharks and Teleost Fishes in the Florida Big Bend. [Internet] [Masters thesis]. Florida State University; 2014. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8868 ;.

Council of Science Editors:

Peterson CT. Distribution and Abundance, Community Structure, and Trophic Ecology of Sharks and Teleost Fishes in the Florida Big Bend. [Masters Thesis]. Florida State University; 2014. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8868 ;

Florida State University

16. Richards, Travis Mark. Trophic Dynamics of Spotted Seatrout (Cynoscion Nebulosus) in a River-Dominated Coastal Estuary, Apalachicola Bay, Florida.

Degree: MS, Biological Science, 2014, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8875 ;

► Estuaries are one of the most ecologically and economically valuable habitats on earth in part due to high nutrient inputs from their associated watersheds that… (more)

▼ Estuaries are one of the most ecologically and economically valuable habitats on earth in part due to high nutrient inputs from their associated watersheds that supports high productivity of fish populations. While numerous studies have investigated the spatial and trophic dynamics of estuarine fish communities, few of these studies have included estuarine piscivores that typically occupy the highest trophic level in the system. The overall objective of this research is to investigate the trophic dynamics of top-level consumers in relation to habitat (e.g., marine seagrass, saltmarsh) and environmental (e.g., river flow) factors using spotted seatrout (Cynoscion nebulosus) as a focal species. My primary objectives are to: (1) determine the role of alternative nutrient sources underlying the productivity of seatrout, and (2) investigate how diet, nutritional condition, and trophic level of spotted seatrout vary spatially and temporally in relation to habitat type and variable river flow. Dietary analysis of spotted seatrout yielded 1338 prey items from 28 different prey categories representing 14 families of fishes, three families of shrimp, one family of crab, two classes of mollusk and two orders of crustacean. Teleost fishes and penaeid shrimp were identified as the two most important prey types supporting spotted seatrout in Apalachicola Bay. Within the large category of teleost fishes, species belonging to the families Engraulidae and Sciaenidae were the most numerically abundant and frequently occurring in the diets of spotted seatrout. Juvenile spotted seatrout fed more frequently on decapod shrimp than teleosts while adult trout fed roughly equally on teleost fishes and decapod shrimp. Regional and seasonal differences within the diet community of spotted seatrout were primarily driven by the seasonal and regional differences in penaeid shrimp distribution and abundance. Results of stable isotope analysis revealed significant regional and seasonal structuring in the δ13C, δ15N, and δ34S ratios of spotted seatrout in Apalachicola Bay. Regional variation in 13C and mixing model analysis suggested fish living in the upper regions of the bay are primarily supported by in situ primary production in the form of phytoplankton and terrestrial detritus while secondary production in the outer regions of the bay is most heavily supported by seagrasses. There was little evidence to suggest large changes in the primary source of productivity in each region with seasons. The lower regions of the bay were the only regions to exhibit seasonal changes in primary production seagrass epiphytes played a larger contribution to seatrout production during the fall months. Nitrogen varied regionally and was characterized by elevated levels in the head regions of the by reflecting the dependence of the food web in that area on N enriched sources such as phytoplankton while fish collected in the lower regions of the bay possessed lower nitrogen levels indicative of benthically derived carbon sources. This project provides insight on… Advisors/Committee Members: J. Kevin Craig (professor co-directing thesis), Alice Winn (committee member), Joseph Travis (committee member).

Subjects/Keywords: Biology; Life sciences

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APA (6^th Edition):

Richards, T. M. (2014). Trophic Dynamics of Spotted Seatrout (Cynoscion Nebulosus) in a River-Dominated Coastal Estuary, Apalachicola Bay, Florida. (Masters Thesis). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-8875 ;

Chicago Manual of Style (16^th Edition):

Richards, Travis Mark. “Trophic Dynamics of Spotted Seatrout (Cynoscion Nebulosus) in a River-Dominated Coastal Estuary, Apalachicola Bay, Florida.” 2014. Masters Thesis, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-8875 ;.

MLA Handbook (7^th Edition):

Richards, Travis Mark. “Trophic Dynamics of Spotted Seatrout (Cynoscion Nebulosus) in a River-Dominated Coastal Estuary, Apalachicola Bay, Florida.” 2014. Web. 23 Jan 2021.

Vancouver:

Richards TM. Trophic Dynamics of Spotted Seatrout (Cynoscion Nebulosus) in a River-Dominated Coastal Estuary, Apalachicola Bay, Florida. [Internet] [Masters thesis]. Florida State University; 2014. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8875 ;.

Council of Science Editors:

Richards TM. Trophic Dynamics of Spotted Seatrout (Cynoscion Nebulosus) in a River-Dominated Coastal Estuary, Apalachicola Bay, Florida. [Masters Thesis]. Florida State University; 2014. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8875 ;

Florida State University

17. Janowitz, Ilana L. The Maintenance of Polymorphism by Behavioral and Genomic Plasticity in Mate Preference.

Degree: PhD, Biological Science, 2014, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8814 ;

► The maintenance of genetic variation in traits that are closely tied to fitness, despite evolutionary forces expected to reduce variation, is a long-standing paradox in… (more)

▼ The maintenance of genetic variation in traits that are closely tied to fitness, despite evolutionary forces expected to reduce variation, is a long-standing paradox in evolutionary biology. Under simple population genetic models, genetic variation will be determined by a balance between the input of new variation through mutation and the elimination of variation by selection and genetic drift; however, the ability of these forces to generate and maintain the high variation found in natural populations is a continuing debate. Frequency-dependent selection can maintain extensive variation in natural populations well above the levels predicted by simple population genetic models. In the Trinidad guppy, Poecilia reticulata, negative frequency-dependent selection through a female preference for rare or novel mates is one proposed mechanism maintaining the extreme color polymorphism seen in wild populations. Despite the apparent generality of a female mating preference for novel color patterns in this species, the evolutionary origin of the novel mate preference remains unknown. One hypothesis for the origin of the novel mate preference is that guppies have been selected for increased responsiveness to novel stimuli for reasons unrelated to mating. If response to novel stimuli leads to a selective advantage, such as a competitive foraging advantage, then the novel mate preference could be a pleiotropic side-effect of selection for increased efficiency in foraging. To determine whether the novel mate preference is due to a generalized preference for novel stimuli, I conducted two experiments. In the first experiment, I examined the molecular changes occurring in female brains when exposed to a male with a novel versus a familiar color pattern. If mate preference for novel coloration is a byproduct of a general preference for novelty, I predicted that genes previously implicated in novelty-seeking would be differentially expressed in females exposed to males with novel compared to familiar color patterns. While I did find genes specifically related to novelty-seeking, I found over 150 other genes that were differentially expressed between the novel and familiar behavior treatments, suggesting that female perception of novel mates is physiologically complex and is correlated with a series of transcriptional changes. In the second experiment, I examined the preference for novel environmental stimuli. I compared the behavioral responses of guppies exposed to novel versus familiar objects and novel versus familiar food sources. Overall, neither male nor female guppies demonstrated a strong preference for environmental novelty. In a third experiment, I examined the mating patterns in a species closely-related to the guppy, Poecilia picta. I conducted a series of experiments to determine whether P. picta show a preference for rare males or males with novel color patterns. While I did not find a female preference for males that exhibited the locally rare color pattern found in natural populations, I did determine that female P.… Advisors/Committee Members: Kimberly A. Hughes (professor directing dissertation), James F. Johnson (university representative), Emily DuVal (committee member), Emily Lemmon (committee member), Joseph Travis (committee member).

Subjects/Keywords: Biology; Life sciences

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APA (6^th Edition):

Janowitz, I. L. (2014). The Maintenance of Polymorphism by Behavioral and Genomic Plasticity in Mate Preference. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-8814 ;

Chicago Manual of Style (16^th Edition):

Janowitz, Ilana L. “The Maintenance of Polymorphism by Behavioral and Genomic Plasticity in Mate Preference.” 2014. Doctoral Dissertation, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-8814 ;.

MLA Handbook (7^th Edition):

Janowitz, Ilana L. “The Maintenance of Polymorphism by Behavioral and Genomic Plasticity in Mate Preference.” 2014. Web. 23 Jan 2021.

Vancouver:

Janowitz IL. The Maintenance of Polymorphism by Behavioral and Genomic Plasticity in Mate Preference. [Internet] [Doctoral dissertation]. Florida State University; 2014. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8814 ;.

Council of Science Editors:

Janowitz IL. The Maintenance of Polymorphism by Behavioral and Genomic Plasticity in Mate Preference. [Doctoral Dissertation]. Florida State University; 2014. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8814 ;

Florida State University

18. McKnight, Kelly L. Transcriptional Regulation in Response to DNA Replication Stress.

Degree: PhD, Biomedical Sciences, 2014, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8843 ;

►

When cells encounter DNA replication stress, the S-phase checkpoint is activated to facilitate cell cycle arrest and DNA repair. An important aspect of the checkpoint… (more)

▼

When cells encounter DNA replication stress, the S-phase checkpoint is activated to facilitate cell cycle arrest and DNA repair. An important aspect of the checkpoint is the transcriptional response, but the details governing this response are poorly understood. Intragenic transcription initiates within the coding region of a gene, thereby producing shorter mRNAs and proteins. However, the role of intragenic transcription in the functional regulation of genes remains largely unknown. Previous work has shown that the spindle is stabilized during replication stress to prevent chromosome segregation errors, but the mechanism for the stabilization remains unclear. When yeast cells were treated with hydroxyurea (HU) to block DNA synthesis and induce replication stress, we found that Ase1, a highly conserved spindle midzone protein, appeared as two short protein isoforms in addition to the full length protein. We further demonstrated that the short protein isoforms result from intragenic transcription of ASE1, which depends on the S-phase checkpoint kinase Rad53. Blocking the generation of short Ase1 isoforms leads to increased HU sensitivity and a destabilized S-phase spindle, a likely consequence of altered spindle dynamics and collapse. The short Ase1 protein isoforms induced during replication stress act dominant negatively to maintain a stable spindle structure during HU arrest, likely by regulating microtubule motor protein activity. It is well documented that the transcription of some genes exhibit Rad53-dependent changes during DNA replication stress. We suspect that more genes are subjected to Rad53-dependent transcriptional regulation in response to DNA replication stress. For this purpose, we used both a tiling microarray and RNA-sequencing to systematically identify Rad53-dependent transcription in cell cycle control. As a result we identified a large number of genes whose transcription is regulated in response to HU treatment and depends on Rad53. Furthermore, we provide insight into the mechanism responsible for mitotic gene repression with evidence that supports the role of the transcriptional repressor Yox1 in Rad53-dependent transcriptional regulation. Together, our results reveal a unique mechanism that down-regulates gene function by intragenic transcription. Additionally, our systematic identification of differential gene expression in response to DNA replication stress using RNA-sequencing was successful in identifying potential Rad53-depedendent transcription targets.

A Dissertation submitted to the Department of Biomedical Sciences in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

Spring Semester, 2014.

March 10, 2014.

Yanchang Wang, Professor Directing Dissertation; Wu-Min Deng, University Representative; Hong-Guo Yu, Committee Member; Yoichi Kato, Committee Member; Akash Gunjan, Committee Member; Jamila Horabin, Committee Member.

Advisors/Committee Members: Yanchang Wang (professor directing dissertation), Wu-Min Deng (university representative), Hong-Guo Yu (committee member), Yoichi Kato (committee member), Akash Gunjan (committee member), Jamila Horabin (committee member).

Subjects/Keywords: Biology; Life sciences

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APA (6^th Edition):

McKnight, K. L. (2014). Transcriptional Regulation in Response to DNA Replication Stress. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-8843 ;

Chicago Manual of Style (16^th Edition):

McKnight, Kelly L. “Transcriptional Regulation in Response to DNA Replication Stress.” 2014. Doctoral Dissertation, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-8843 ;.

MLA Handbook (7^th Edition):

McKnight, Kelly L. “Transcriptional Regulation in Response to DNA Replication Stress.” 2014. Web. 23 Jan 2021.

Vancouver:

McKnight KL. Transcriptional Regulation in Response to DNA Replication Stress. [Internet] [Doctoral dissertation]. Florida State University; 2014. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8843 ;.

Council of Science Editors:

McKnight KL. Transcriptional Regulation in Response to DNA Replication Stress. [Doctoral Dissertation]. Florida State University; 2014. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8843 ;

Florida State University

19. Druliner, Brooke Roberts. Comprehensive Chromatin Structure Mapping of the Human Genome in Cancer Progression.

Degree: PhD, Biological Science, 2014, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8771 ;

►

A hallmark of cancerous transformation is altered chromosome structure. Inappropriate regulation of chromatin structure inhibits normal cell function, and may represent the origin of transformation.… (more)

▼

A hallmark of cancerous transformation is altered chromosome structure. Inappropriate regulation of chromatin structure inhibits normal cell function, and may represent the origin of transformation. A handful of important studies have indicated that chromatin structure in the human genome is dynamic and regulatory, but the role of chromatin structure in cancer progression has not been addressed. In our initial studies, we have analyzed chromatin structure of patients with different grades and stages of adenocarcinoma as compared to matched normal tissue using microarray-based nucleosome distribution and chromosomal sensitivity assays. We report that low-grade lung adenocarcinoma displays widespread nucleosome alterations compared to matched normal tissue at over half of 886 genes studied, and that these changes are consistent between patients. Additionally, we determined many changes in early colorectal adenocarcinoma, and the alterations are consistent between patients and concordant with the lung adenocarcinoma alterations. Genes with nucleosome distribution changes are enriched for the phosphoinositide 3-kinase (PI3K) cascade, a key oncoregulatory pathway. Together these results suggest an early, shared regulatory mechanism of transformation. We have also measured substantial disruptions in chromosomal sensitivity in a high-grade and high-stage tumor, linking aggressive tumors with high-order nuclear architecture alterations. From this initial study, we have developed a model in which early adenocarcinoma is linked to changes in nucleosome distributions, whereas aggressive tumors are linked to high-order chromosomal changes. This work has laid the foundation for comprehensive studies on the role of chromatin structure in cancer progression. As such, we have developed a new approach to generate ultra high-resolution, genome-wide nucleosome distribution maps at the transcription start site using deep sequencing, which we call mTSS-seq. Building on the published microarray-based nucleosome distribution mapping of select loci in adenocarcinoma patients, we have provided the first measurements of genome-wide nucleosome distribution using mTSS-seq. We have confirmed that nucleosome distribution is an early, widespread transformation event in lung and colon adenocarcinoma. These findings guide a shift in our perspective from chromatin structural alterations as terminal states to transient events of clinical importance. These altered nucleosome architectures are consistent between patients indicating that they may serve as important early adenocarcinoma markers. We present evidence that the nucleosome alterations are driven by and may influence cis and trans acting factors - the underlying DNA sequence and transcription factor binding. Our study reveals at unprecedented breadth and depth that DNA-directed nucleosome redistributions are a widespread feature early in the progression of cancer, which has allowed us to propose a hierarchical model for genome regulation through chromatin structure.

A Dissertation submitted…

Advisors/Committee Members: Jonathan H. Dennis (professor directing dissertation), Myra M. Hurt (university representative), Brian P. Chadwick (committee member), Hengli Tang (committee member).

Subjects/Keywords: Biology; Life sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Druliner, B. R. (2014). Comprehensive Chromatin Structure Mapping of the Human Genome in Cancer Progression. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-8771 ;

Chicago Manual of Style (16^th Edition):

Druliner, Brooke Roberts. “Comprehensive Chromatin Structure Mapping of the Human Genome in Cancer Progression.” 2014. Doctoral Dissertation, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-8771 ;.

MLA Handbook (7^th Edition):

Druliner, Brooke Roberts. “Comprehensive Chromatin Structure Mapping of the Human Genome in Cancer Progression.” 2014. Web. 23 Jan 2021.

Vancouver:

Druliner BR. Comprehensive Chromatin Structure Mapping of the Human Genome in Cancer Progression. [Internet] [Doctoral dissertation]. Florida State University; 2014. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8771 ;.

Council of Science Editors:

Druliner BR. Comprehensive Chromatin Structure Mapping of the Human Genome in Cancer Progression. [Doctoral Dissertation]. Florida State University; 2014. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-8771 ;

Florida State University

20. Cope, Elise Cook. Use of Zinc to Improve Molecular, Cellular, and Behavioral Outcomes Following Traumatic Brain Injury.

Degree: PhD, Biomedical Sciences, 2013, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7760 ;

►

Depression, anxiety, and impairments in learning and memory are all associated with traumatic brain injury (TBI). While zinc deficiency has been correlated with depression, supplemental… (more)

▼

Depression, anxiety, and impairments in learning and memory are all associated with traumatic brain injury (TBI). While zinc deficiency has been correlated with depression, supplemental zinc appears to have antidepressant effects in both humans and rodent models. We hypothesized that zinc supplementation normalizes gene expression, enhances TBI-induced hippocampal neurogenesis, and prevents injury-related behaviors in a rat model of TBI. Adult male rats were fed a marginal zinc deficient (5 ppm), zinc-adequate (30 ppm), or zinc supplemented (180 ppm) diet for 4 wk followed by a moderately-severe TBI to the frontal cortex produced by controlled cortical impact. This injury induces depression- and anxiety-like behaviors as well as impairments in the Morris water maze (MWM) test. While moderate zinc deficiency did not worsen outcomes following TBI, supplemental zinc resulted in significant reductions in post-injury adrenal gland weights and clear trends toward reduced anxiety. Furthermore, zinc supplemented diets significantly reduced anhedonia, a depression-like behavior, and significantly improved MWM performance after TBI. A second study was performed to examine the possible efficacy of providing supplemental zinc as a treatment after injury. While zinc treatment performance in the MWM test, it was not as effective in treating depression and did not reduce adrenal weight. To elucidate the neurobiological mechanisms responsible for the improvements in behavioral resiliency, we took both a cellular and molecular approach. First, we tested the hypothesis that zinc supplementation increases hippocampal stem cell proliferation and survival. TBI doubled the number of proliferating cells in the dentate gyrus 24 h post-injury, and supplemental zinc increased this number by an additional 2-fold. The long term fate of these proliferating cells was determined 1 wk after TBI. While the number proliferating cells decreased at the same rate in zinc supplemented and in zinc adequate fed rats, the total number of stem cells was almost 60% higher in supplemented animals 1 wk after TBI. Secondly, we employed a large scale genomic analysis of differential gene expression in the hippocampus. TBI altered the expression of over 170 mRNAs, approximately 70 of which were normalized in rats supplemented with zinc. This included genes involved in endogenous repair processes such as neurotransmission, proliferation, survival, differentiation, synaptic plasticity, and protein biosynthesis. The data suggest that chronic zinc supplementation may be a novel and effective strategy for improving the cellular, molecular, and behavioral outcomes associated with TBI.

A Dissertation submitted to the Department of Biomedical Sciences in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

Summer Semester, 2013.

June 5, 2013.

depression, stem cells, traumatic brain injury, zinc

Cathy W. Levenson, Professor Directing Dissertation; Richard Hyson, University Representative; J. Michael Overton, Committee…

Advisors/Committee Members: Cathy W. Levenson (professor directing dissertation), Richard Hyson (university representative), J. Michael Overton (committee member), Mohamed Kabbaj (committee member).

Subjects/Keywords: Biology; Life sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cope, E. C. (2013). Use of Zinc to Improve Molecular, Cellular, and Behavioral Outcomes Following Traumatic Brain Injury. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-7760 ;

Chicago Manual of Style (16^th Edition):

Cope, Elise Cook. “Use of Zinc to Improve Molecular, Cellular, and Behavioral Outcomes Following Traumatic Brain Injury.” 2013. Doctoral Dissertation, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-7760 ;.

MLA Handbook (7^th Edition):

Cope, Elise Cook. “Use of Zinc to Improve Molecular, Cellular, and Behavioral Outcomes Following Traumatic Brain Injury.” 2013. Web. 23 Jan 2021.

Vancouver:

Cope EC. Use of Zinc to Improve Molecular, Cellular, and Behavioral Outcomes Following Traumatic Brain Injury. [Internet] [Doctoral dissertation]. Florida State University; 2013. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7760 ;.

Council of Science Editors:

Cope EC. Use of Zinc to Improve Molecular, Cellular, and Behavioral Outcomes Following Traumatic Brain Injury. [Doctoral Dissertation]. Florida State University; 2013. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7760 ;

Florida State University

21. Hollensead, Lisa D. Monitoring Movement Patterns of Juvenile Smalltooth Sawfish (Pristis Pectinata) Using Acoustic Monitoring and Tracking in a Nursery Habitat in Southwest Florida.

Degree: MS, Biological Science, 2012, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4915 ;

► Habitat use studies can be used to both investigate ecological and behavioral patterns of animals as well as provide a useful management tool for conservation… (more)

▼ Habitat use studies can be used to both investigate ecological and behavioral patterns of animals as well as provide a useful management tool for conservation planners. However, essential habitat can be difficult to determine for highly mobile marine animals, especially when these species are rare or endangered. While critical habitat has been very broadly delineated for the endangered smalltooth sawfish (Pristis pectinata), essential fish habitat (EFH) within the nursery has not been fully described. I used telemetry methods to determine daily activity spaces and rates of movement (ROM) of juvenile P. pectinata in a nursery in southwest Florida. These results were tested for differences in diel and tidal patterns of activity. Seven juvenile animals ranging in size from 85 - 175 cm fork length were tagged in April - September 2011. Overall, activity spaces ranged from 0.07 - 0.17 km2 using 95% Minimum Convex Polygons (MCP), 0.01 - 0.16 km2 based on 50% kernel density estimates (KDE), and 0.08 - 0.68 km2 based on 95% (KDE). Average ROMs ranged from 2.4 - 6.1 meters/min. Activity space and ROMs reflected the morphology of the bay in which the animal was tracked such that fish in small bays had small activity spaces and ROMs. There were no detectable differences in activity space or ROM between ebb and flood tide or high or low tide. Activity space decreased and ROM increased at night indicating possible foraging behavior at night. A home range (1.7 km2) was calculated for one animal. Daily asymptotes in space used were reached for all other tracks suggesting daily activity spaces were determined despite relatively short tracking durations. Bays, estuaries, and other discrete coastal habitats are highly productive and serve as nurseries for a variety of marine fishes. Nurseries are particularly crucial for batoids whose life histories are dependent on rapid growth in the first year, and they may be especially important for rare or endangered species within the group. The smalltooth sawfish, Pristis pectinata, are an endangered marine elasmobranch that makes use of specific nurseries in southwest Florida. While habitat and environmental parameters have been described within the nursery, specific characteristics of the habitats, such as mangrove morphology and sediment types associated with habitat use have not been identified. Two mangrove characteristics (prop root density and limb overhang) and two sediment characteristics (percent organic and percent silt) were used as independent variables to construct a habitat model. Acoustic monitoring was used to examine long term (weeks or months) patterns in habitat use in nursery areas during the critical first year of life. Twenty young-of-the-year sawfish were acoustically tagged between April and October of 2011, and detected by an array of 32 VEMCO VR2w receivers in a documented nursery within Everglades National Park. Presence in the array for individual smalltooth sawfish ranged from one day to 197 days, and overall P. pectinata were present within the acoustic array for… Advisors/Committee Members: Don R. Levitan (professor co-directing thesis), Emily H. DuVal (committee member), Jeanette L. Wulff (committee member), John K. Carlson (committee member).

Subjects/Keywords: Biology; Life sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hollensead, L. D. (2012). Monitoring Movement Patterns of Juvenile Smalltooth Sawfish (Pristis Pectinata) Using Acoustic Monitoring and Tracking in a Nursery Habitat in Southwest Florida. (Masters Thesis). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-4915 ;

Chicago Manual of Style (16^th Edition):

Hollensead, Lisa D. “Monitoring Movement Patterns of Juvenile Smalltooth Sawfish (Pristis Pectinata) Using Acoustic Monitoring and Tracking in a Nursery Habitat in Southwest Florida.” 2012. Masters Thesis, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-4915 ;.

MLA Handbook (7^th Edition):

Hollensead, Lisa D. “Monitoring Movement Patterns of Juvenile Smalltooth Sawfish (Pristis Pectinata) Using Acoustic Monitoring and Tracking in a Nursery Habitat in Southwest Florida.” 2012. Web. 23 Jan 2021.

Vancouver:

Hollensead LD. Monitoring Movement Patterns of Juvenile Smalltooth Sawfish (Pristis Pectinata) Using Acoustic Monitoring and Tracking in a Nursery Habitat in Southwest Florida. [Internet] [Masters thesis]. Florida State University; 2012. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4915 ;.

Council of Science Editors:

Hollensead LD. Monitoring Movement Patterns of Juvenile Smalltooth Sawfish (Pristis Pectinata) Using Acoustic Monitoring and Tracking in a Nursery Habitat in Southwest Florida. [Masters Thesis]. Florida State University; 2012. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4915 ;

Florida State University

22. Strimaitis, Anna Margaret. Filter Feeding Ecology of Erect Branching Sponges on Caribbean Coral Reefs.

Degree: MS, Biological Science, 2012, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5999 ;

► Sponges are unique filter feeding organisms with complex canal and flagellated chamber aquiferous systems. These systems allow them to specialize in clearing the smallest plankton… (more)

▼ Sponges are unique filter feeding organisms with complex canal and flagellated chamber aquiferous systems. These systems allow them to specialize in clearing the smallest plankton size class (picoplankton) from the water. Sponges serve many important ecological functions, but they may be best known for efficiently filtering picoplankton, such as phytoplankton bloom species, from the water column. This ecological function increases water clarity and allows more light to penetrate to photosynthesizing corals and sea grasses. As abundant and efficient members of the benthic filter-feeding community, it is important to understand how and to what extent sponges can maintain water quality on healthy coral reefs and restore water quality on declining coral reefs. The first goal of this research was to quantify and compare the abundance of picoplankton resources, in terms of number of cells and carbon and nitrogen content, available to sponge filter feeders in Caribbean coral reef, mangrove, and sea grass habitats. The four primary picoplankton prey types (picoeukaryotes, cyanobacteria, prochlorophytes, and heterotrophic bacteria) were quantified using flow cytometry. Data were also collected on light intensity and dissolved nutrient concentrations because some sponge species harbor phototrophic and heterotrophic bacterial symbionts that can utilize these resources. We studied sites in all three habitats near Carrie Bow Cay, Belize, two reef sites and one mangrove site in Bocas del Toro, Panama, and one reef site in Curacao. These sites were chosen specifically to explain observed patterns in long-term sponge growth rate data that suggest resource limitation. Overall, heterotroph cell densities and carbon and nitrogen were greater at the mangrove sites than at the reef sites, but autotroph cell densities and carbon and nitrogen at the reefs sites were greater than or equal to those at the mangrove sites. Furthermore, there were greater heterotroph and autotroph cell densities and carbon and nitrogen at the reef sites in Bocas del Toro than at the reef sites in Belize and Curacao, and the autotroph cell densities and carbon and nitrogen were also greater at the mangrove site in Bocas del Toro than the mangrove site in Belize. The second goal of this research was to quantify and compare the effect of sponge grazing on the four picoplankton prey types, the clearance rate of each prey type for each species, and selectivity (i.e. clearance rate standardized by relative abundance of prey types in the ambient water). These variables were quantified and compared for six of the most common erect branching sponge species representing three different orders at the reef sites in Belize and Panama: Aplysina cauliformis (Order Verongida), Aplysina fulva (Order Verongida), Desmapsamma anchorata (Order Poecilosclerida), Iotrochota birotulata (Order Poecilosclerida), Niphates erecta (Order Haplosclerida), and Amphimedon compressa (Order Haplosclerida). Sponge feeding was quantified using chamber experiments that compared the change in prey… Advisors/Committee Members: Janie L. Wulff (professor directing thesis), Markus Huettel (university representative), Don R. Levitan (committee member), Alice A. Winn (committee member), Kay M. Jones (committee member).

Subjects/Keywords: Biology; Life sciences

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APA (6^th Edition):

Strimaitis, A. M. (2012). Filter Feeding Ecology of Erect Branching Sponges on Caribbean Coral Reefs. (Masters Thesis). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-5999 ;

Chicago Manual of Style (16^th Edition):

Strimaitis, Anna Margaret. “Filter Feeding Ecology of Erect Branching Sponges on Caribbean Coral Reefs.” 2012. Masters Thesis, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-5999 ;.

MLA Handbook (7^th Edition):

Strimaitis, Anna Margaret. “Filter Feeding Ecology of Erect Branching Sponges on Caribbean Coral Reefs.” 2012. Web. 23 Jan 2021.

Vancouver:

Strimaitis AM. Filter Feeding Ecology of Erect Branching Sponges on Caribbean Coral Reefs. [Internet] [Masters thesis]. Florida State University; 2012. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5999 ;.

Council of Science Editors:

Strimaitis AM. Filter Feeding Ecology of Erect Branching Sponges on Caribbean Coral Reefs. [Masters Thesis]. Florida State University; 2012. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5999 ;

Florida State University

23. Middlebrooks, Jennifer Ivey. Characterization of the Lung Seven Transmembrane (LUSTR) Protein Family.

Degree: PhD, Biological Science, 2012, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5800 ;

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Cilia are recognized as an important sensory structure for the cell. However, much about the signaling involved in ciliary outgrowth remains a mystery. Chlamydomonas, a… (more)

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Cilia are recognized as an important sensory structure for the cell. However, much about the signaling involved in ciliary outgrowth remains a mystery. Chlamydomonas, a green algae, is a model for ciliary and flagellar studies owing to its pair of anterior flagella and haploid genome. In a previous study of gene expression during flagellar outgrowth in Chlamydomonas after environmental shock, the gene encoding a predicted seven transmembrane protein (Cr7TM) was differentially expressed. Subsequent experiments described here have attempted to elucidate the function of Cr7TM in the cell and specifically in the flagella. Bioinformatic search techniques and predictions of the evolutionary history of Cr7TM and its homologues imply that this LUSTR protein family is unique in both its primary structure and mechanisms for protein interaction. It is also highly conserved and likely involved in a critical cellular function. LUSTR proteins are ubiquitously expressed across metazoan organisms and tissue types. Also, Cr7TM is differentially expressed during outgrowth of cilia/flagella but not during oxidative stress, indicating Cr7TM's involvement in flagellar outgrowth rather than the stress response. Fluorescence microscopy indicates that Cr7TM co-localizes with acetylated á-tubulin in the flagella. Creation of an inducible knockdown mutant line of Cr7TM allowed for comparison of the phenotypes between induced and uninduced RNAi knockdown mutant lines. The Cr7TM knockdown line demonstrates a diminished cell size along with a rapid increase in the density of cell cultures as compared to the control, indicating a possible cellular role for Cr7TM in cell cycling or mitotic regulation. Additionally, imaging of human embryonic kidney cells shows colocalization of LUSTR proteins near the highly conserved centriole and basal body organelles. When taken together the high degree of sequence conservation, knockdown phenotype and cellular localization of LUSTR proteins provide evidence for LUSTR involvement in the regulation of cell cycle.

A Dissertation submitted to the Department of Biological Science in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

Summer Semester, 2012.

June 1, 2012.

CHLAMYDOMONAS, CILIA, FLAGELLA, GPR107, LUSTR, TRANSMEMBRANE

Laura R. Keller, Professor Directing Dissertation; Cathy Levenson, University Representative; Tom Keller, Committee Member; Karen McGinnis, Committee Member; Wumin Deng, Committee Member.

Advisors/Committee Members: Laura R. Keller (professor directing dissertation), Cathy Levenson (university representative), Tom Keller (committee member), Karen McGinnis (committee member), Wumin Deng (committee member).

Subjects/Keywords: Biology; Life sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Middlebrooks, J. I. (2012). Characterization of the Lung Seven Transmembrane (LUSTR) Protein Family. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-5800 ;

Chicago Manual of Style (16^th Edition):

Middlebrooks, Jennifer Ivey. “Characterization of the Lung Seven Transmembrane (LUSTR) Protein Family.” 2012. Doctoral Dissertation, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-5800 ;.

MLA Handbook (7^th Edition):

Middlebrooks, Jennifer Ivey. “Characterization of the Lung Seven Transmembrane (LUSTR) Protein Family.” 2012. Web. 23 Jan 2021.

Vancouver:

Middlebrooks JI. Characterization of the Lung Seven Transmembrane (LUSTR) Protein Family. [Internet] [Doctoral dissertation]. Florida State University; 2012. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5800 ;.

Council of Science Editors:

Middlebrooks JI. Characterization of the Lung Seven Transmembrane (LUSTR) Protein Family. [Doctoral Dissertation]. Florida State University; 2012. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5800 ;

Florida State University

24. Meyer, Nancy. Role of Cardiac Troponin I's Carboxy Terminus in Regulating Cardiac Contraction.

Degree: MS, Biological Science, 2012, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5826 ;

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Normal cardiac function involves the highly regulated switching of contraction on and off by Ca2+-dependent conformational changes in the troponin-tropomyosin complex. A myriad of factors,… (more)

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Normal cardiac function involves the highly regulated switching of contraction on and off by Ca2+-dependent conformational changes in the troponin-tropomyosin complex. A myriad of factors, both biochemical and mechanical, adaptively modulate the regular systole-diastole transition , though all ultimately act through the proteins of the sarcomere. Among the most influential is the ternary troponin complex, lesions of which account for the etiology of a number of cardiomyopathies, including dilated cardiomyopathy, familial hypertrophic cardiomyopathy, and myocardial stunning. The latter can often be traced in particular to dysfunction of cardiac troponin I, the "inhibitory" subunit and directly key to the on/off movements of tropomyosin on the thin filament. This research examines the Ca2+-dependent regulatory role of cardiac troponin I's C-terminus in vitro, as well as its development as a clinical marker for use in SnO2 nanobelt FET biosensors. Investigations into how cardiac troponin I's C-terminal mobile domain and adjacent regions contribute to the Ca2+-dependent "switch" were conducted using thein vitromotility assay. Specifically, we test the hypothesis that cTnI's mobile domain is tightly-coupled to the so-called switch peptide domain, to which it is immediately adjacent. The ability of wild-type cardiac troponin complexes to regulate filament sliding was compared to that of complexes containing one of two mutant cardiac troponin Is: a C-terminally truncated cardiac troponin I lacking the mobile domain, and a cardiac troponin I that incorporated an 8-residue flexible linker between the switch peptide and mobile domain. We find that neither mutation affected maximum filament sliding speeds, indicating that neither the mobile domain nor its adjacency to the switch peptide are required for full activation in the presence of Ca2+. Each mutant complex was found to increase the Ca2+-sensitivity of activation, presumably in different ways. Cooperativity coefficients decreased with each compared to wild type, which agrees with a more permissive range of motion for the switch peptide (i.e. a more ready association with the N-lobe of troponin C) in which fewer activated regulatory units are required to effect the same activating level of crossbridge association. The truncated troponin I complex also failed to fully inhibit filament sliding at low [Ca2+], showing that while the mobile domain is necessary for full Ca2+-dependent inhibition, some inhibitory interaction with actin-tropomyosin remains. These efforts have been timely because, with increasing structural data, it has recently become possible to test detailed hypotheses about the functional role of the of cardiac troponin I C-terminus in Ca2+regulation of thin filaments. It has also been of clinical importance to optimize point-of-care troponin I biosensor devices for the rapid and reliable detection of this myocardial infarction marker.

A Thesis submitted to the Department of Biological Science in partial fulfillment of the requirements for the degree of…

Advisors/Committee Members: P. Bryant Chase (professor directing thesis), Kenneth Taylor (committee chair), Piotr Fajer (committee member).

Subjects/Keywords: Biology; Life sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Meyer, N. (2012). Role of Cardiac Troponin I's Carboxy Terminus in Regulating Cardiac Contraction. (Masters Thesis). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-5826 ;

Chicago Manual of Style (16^th Edition):

Meyer, Nancy. “Role of Cardiac Troponin I's Carboxy Terminus in Regulating Cardiac Contraction.” 2012. Masters Thesis, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-5826 ;.

MLA Handbook (7^th Edition):

Meyer, Nancy. “Role of Cardiac Troponin I's Carboxy Terminus in Regulating Cardiac Contraction.” 2012. Web. 23 Jan 2021.

Vancouver:

Meyer N. Role of Cardiac Troponin I's Carboxy Terminus in Regulating Cardiac Contraction. [Internet] [Masters thesis]. Florida State University; 2012. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5826 ;.

Council of Science Editors:

Meyer N. Role of Cardiac Troponin I's Carboxy Terminus in Regulating Cardiac Contraction. [Masters Thesis]. Florida State University; 2012. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5826 ;

Florida State University

25. Klusza, Stephen. Characterization of Germ-Line Endopolyploid Chromatin Dispersal in Drosophila Oogenesis.

Degree: PhD, Biological Science, 2011, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5746 ;

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Drosophila melanogasterfemale fruit flies possess a pair of ovaries in which many egg chambers are produced, each containing an oocyte that houses the haploid female… (more)

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Drosophila melanogasterfemale fruit flies possess a pair of ovaries in which many egg chambers are produced, each containing an oocyte that houses the haploid female gamete. In the process of oogenesis, the multi-cellular egg chamber is composed of somatic follicle cells which encapsulate the germ-cells (1 oocyte and 15 nurse cells); the germ-line nurse cells produce an enormous amount of RNAs and proteins that are needed for growth and morphological changes of the egg chamber to aid in the development of the oocyte in preparation for fertilization and embryogenesis. Intriguingly, nurse-cell (NC) nuclei undergo the endocycle in which DNA is re-replicated in the absence of mitosis, creating visible chromatin structures. During stages 4-6 of oogenesis, the NC nuclei undergo a dramatic change in morphology from a visible polytenic state to a diffuse state via a transient condensation phase. Mutations in many genes involved in various transcriptional, splicing, and translational processes routinely retain nurse-cell chromatin dispersal (NCCD) failure phenotypes, in which NC chromatin never disperse in the later stages of oogenesis. However, the significance of NCCD remains elusive in terms of its effect on essential processes like ribosomal synthesis of proteins or oocyte polarization. In order to investigate in greater detail the conditions required for NCCD, I first identify the novel genepolythrough a traditional FLP-FRT mosaic clone screen and characterize its requirement in the germ-line for NCCD and oocyte polarization. Later on, I also demonstrate that that NCCD itself does not affect oocyte polarity, through studies of anovarian tumormutation haploinsufficient for NCCD. However, performing a genetic modifier screen with theovarian tumormutation yields many loci that affect the morphology of NC chromatin, suggesting that NCCD is sensitive to genetic background. In the third part, I characterize mutations inpeanuts, a spliceosomal protein isolated from the screen, and its role in mediating spliceosomal function and NCCD, thus validating the screen as a tool for further identification of genes that affect chromatin dynamics.

A Dissertation submitted to the Department of Biological Science in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

Fall Semester, 2011.

September 22, 2011.

chromatin, Drosophila, nurse cells, oogenesis, splicing

Wu-Min Deng, Professor Directing Dissertation; Qiang-Xing (Amy) Sang, University Representative; Hank W. Bass, Committee Member; Laura R. Keller, Committee Member; Jamila Horabin, Committee Member.

Advisors/Committee Members: Wu-Min Deng (professor directing dissertation), Qiang-Xing (Amy) Sang (university representative), Hank W. Bass (committee member), Laura R. Keller (committee member), Jamila Horabin (committee member).

Subjects/Keywords: Biology; Life sciences

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Klusza, S. (2011). Characterization of Germ-Line Endopolyploid Chromatin Dispersal in Drosophila Oogenesis. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-5746 ;

Chicago Manual of Style (16^th Edition):

Klusza, Stephen. “Characterization of Germ-Line Endopolyploid Chromatin Dispersal in Drosophila Oogenesis.” 2011. Doctoral Dissertation, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-5746 ;.

MLA Handbook (7^th Edition):

Klusza, Stephen. “Characterization of Germ-Line Endopolyploid Chromatin Dispersal in Drosophila Oogenesis.” 2011. Web. 23 Jan 2021.

Vancouver:

Klusza S. Characterization of Germ-Line Endopolyploid Chromatin Dispersal in Drosophila Oogenesis. [Internet] [Doctoral dissertation]. Florida State University; 2011. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5746 ;.

Council of Science Editors:

Klusza S. Characterization of Germ-Line Endopolyploid Chromatin Dispersal in Drosophila Oogenesis. [Doctoral Dissertation]. Florida State University; 2011. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-5746 ;

Florida State University

26. Figueroa, Debbie. Development of Pachytene Cytogenetic Fluorescence in Situ Hybridization (FISH) Maps for Six Maize Chromosomes: Insights into Genome Structure Dynamics.

Degree: PhD, Biological Science, 2011, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4828 ;

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Plant cytogenetics has continued to flourish and make essential contributions to genomics projects by delineating marker order, defining contig gaps, and revealing genome rearrangements. Here… (more)

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Plant cytogenetics has continued to flourish and make essential contributions to genomics projects by delineating marker order, defining contig gaps, and revealing genome rearrangements. Here we review the field of plant cytogenetics from its conception through the eras of molecular biology and genomics (Chapter 1). Significant advances in chromosome preparation, such as extended fiber-FISH, have greatly increased the axial resolution limits, while imaging and signal amplification technologies have improved our ability to detect small gene-sized probes. These advances are described, together with selected examples that illustrate the power of plant cytogenetics in guiding genome projects. The integration of genetic and physical maps of maize is progressing rapidly, but the cytogenetic maps lag behind, with the exception of the pachytene fluorescence in situ hybridization (FISH) maps of maize chromosome 9. We sought to produce integrated FISH maps of other maize chromosomes using the landmark Core Bin Marker loci. Because these 1 Kb restriction fragment length polymorphism (RFLP) probes are below the FISH detection limit, we used BACs from sorghum, a small-genome relative of maize, as surrogate clones for FISH mapping. We sequenced 151 maize RFLP probes and compared in silico BAC selection methods to that of library filter hybridization and found the latter to be the best. BAC library screening, clone verification, and single-clone selection criteria are presented in Chapter 2. The use of homologous sorghum BACs as representative FISH probes for the creation of cytogenetic FISH maps for six maize chromosomes as well as in the mapping of duplicate maize regions are presented in Chapters 3 and 4, respectively. Finally, in Chapter 5 we compare our pachytene cytogenetic maps as well as the high-density chromosome 9 FISH map to the maize genomic map (Schnable et al., 2009), the UMC98 genetic linkage map (Davis et al., 1999), and to recombination nodule-based predictions of meiotic cytological coordinates (Anderson et al., 2004; Lawrence et al., 2006).

A Dissertation submitted to the Department of Biological Science in partial fulfillment of the requirements for the degree of Doctor of Philosophy.

Fall Semester, 2011.

October 14, 2011.

BAC, cytogenetics, FISH, maize, mapping, pachytene

Hank W. Bass, Professor Directing Dissertation; Cathy W. Levenson, University Representative; Austin R. Mast, Committee Member; Lloyd M. Epstein, Committee Member; James M. Fadool, Committee Member.

Advisors/Committee Members: Hank W. Bass (professor directing dissertation), Cathy W. Levenson (university representative), Austin R. Mast (committee member), Lloyd M. Epstein (committee member), James M. Fadool (committee member).

Subjects/Keywords: Biology; Life sciences

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Figueroa, D. (2011). Development of Pachytene Cytogenetic Fluorescence in Situ Hybridization (FISH) Maps for Six Maize Chromosomes: Insights into Genome Structure Dynamics. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-4828 ;

Chicago Manual of Style (16^th Edition):

Figueroa, Debbie. “Development of Pachytene Cytogenetic Fluorescence in Situ Hybridization (FISH) Maps for Six Maize Chromosomes: Insights into Genome Structure Dynamics.” 2011. Doctoral Dissertation, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-4828 ;.

MLA Handbook (7^th Edition):

Figueroa, Debbie. “Development of Pachytene Cytogenetic Fluorescence in Situ Hybridization (FISH) Maps for Six Maize Chromosomes: Insights into Genome Structure Dynamics.” 2011. Web. 23 Jan 2021.

Vancouver:

Figueroa D. Development of Pachytene Cytogenetic Fluorescence in Situ Hybridization (FISH) Maps for Six Maize Chromosomes: Insights into Genome Structure Dynamics. [Internet] [Doctoral dissertation]. Florida State University; 2011. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4828 ;.

Council of Science Editors:

Figueroa D. Development of Pachytene Cytogenetic Fluorescence in Situ Hybridization (FISH) Maps for Six Maize Chromosomes: Insights into Genome Structure Dynamics. [Doctoral Dissertation]. Florida State University; 2011. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4828 ;

Florida State University

27. Boerner, Susan. Identification and Classification of Long Non-Coding RNA in Zea Mays Using Computational and Bioinformatic Approaches.

Degree: MS, Biological Science, 2012, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4724 ;

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Computational analysis of cDNA sequences from multiple organisms suggests that a large portion of transcribed DNA does not code for a functional protein. As studies… (more)

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Computational analysis of cDNA sequences from multiple organisms suggests that a large portion of transcribed DNA does not code for a functional protein. As studies begin to delve into the possible functions of these noncoding transcripts, the results are revealing an ever more complex genome, where what was once dubbed "junk" is now seemingly necessary. The characterization of several long noncoding (lnc)RNAs in human and mouse has involved the analysis of raw genomic sequence data with a set of rules to computationally predict functional noncoding transcripts; other approaches involve expression datasets from microarray or RNAseq technology to achieve the same end. As these studies increase, the number of functions, classes and names, of noncoding transcripts increase as well. Many examples of lncRNAs appear to have an epigenetic role in humans, including HOTAIR and XIST. While epigenetic gene regulation is clearly an essential mechanism in plants, relatively little is known about the presence or function of lncRNAs in plants. To explore the connection between lncRNA and epigenetic regulation of gene expression in plants, a computational pipeline using the programming language Python that will identify, classify, and localize potential lncRNAs has been developed and applied to maize full length cDNA sequences. This analysis revealed that a large portion of transcribed sequences in maize are not predicted to be coding. In addition, over half of the predicted noncoding transcripts contain small RNA sequences. Also, approximately half of the predicted noncoding transcripts are associated with a gene model. Of these, roughly 20 percent are antisense to their host gene loci. Sequence analysis identified a GA rich motif that is similar to two known motifs in previously charatercterized lncRNAs, roX2 and HOTAIR. Overall these results suggest that lncRNAs may be a component of genome regulation in maize.

A Thesis submitted to the Department of Biological Science in partial fulfillment of the requirements for the degree of Master of Science.

Spring Semester, 2012.

March 29, 2012.

long non-coding RNA, maize, non-coding, RNA, Zea mays

Karen McGinnis, Professor Directing Thesis; Hank Bass, Committee Member; Brian Chadwick, Committee Member.

Advisors/Committee Members: Karen McGinnis (professor directing thesis), Hank Bass (committee member), Brian Chadwick (committee member).

Subjects/Keywords: Biology; Life sciences

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Boerner, S. (2012). Identification and Classification of Long Non-Coding RNA in Zea Mays Using Computational and Bioinformatic Approaches. (Masters Thesis). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-4724 ;

Chicago Manual of Style (16^th Edition):

Boerner, Susan. “Identification and Classification of Long Non-Coding RNA in Zea Mays Using Computational and Bioinformatic Approaches.” 2012. Masters Thesis, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-4724 ;.

MLA Handbook (7^th Edition):

Boerner, Susan. “Identification and Classification of Long Non-Coding RNA in Zea Mays Using Computational and Bioinformatic Approaches.” 2012. Web. 23 Jan 2021.

Vancouver:

Boerner S. Identification and Classification of Long Non-Coding RNA in Zea Mays Using Computational and Bioinformatic Approaches. [Internet] [Masters thesis]. Florida State University; 2012. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4724 ;.

Council of Science Editors:

Boerner S. Identification and Classification of Long Non-Coding RNA in Zea Mays Using Computational and Bioinformatic Approaches. [Masters Thesis]. Florida State University; 2012. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4724 ;

Florida State University

28. Asumda, Faizal Z. Nuclear Cardiac Troponins, Tropomyosin and Actin in Native Ventricular Cardiomyocytes.

Degree: MS, Biological Science, 2012, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4698 ;

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Changes in gene expression determine cellular differentiation and developmental programs as cells transform from a progenitor to a mature adult state. The difference in the… (more)

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Changes in gene expression determine cellular differentiation and developmental programs as cells transform from a progenitor to a mature adult state. The difference in the organization of the nucleus between undifferentiated cells and their terminally differentiated counterparts, and the possible mechanisms that determine and alter gene expression in the nucleus is an area of intense investigation. Nuclear actin – which is immunologically distinct from cytoplasmic actin – has been documented in number of differentiated cell types (Bettinger et al., 2004; Dingová et al., 2009 and Gieni et al., 2009) and cardiac isoforms of troponinI (cTnI) and troponinT (cTnT ) have been detected in association with nuclei of adult human cardiacmyocytes (Bergman et al., 2009 and Kajstura et al., 2010). It is not known whether these and related proteins are present in undifferentiated stem cells, or when they appear in cardiomyogenic cells following differentiation. Using an in vitro primary explant cell culture model, I investigated whether nuclear actin and cardiac isoforms of troponin C (cTnC) and tropomyosin (cTm) are present along with cTnI and cTnT in nuclei of isolated, neonatal rat cardiomyocytes in culture. I developed a cell permeabilization and extraction protocol that enabled an unambiguous determination of the distribution pattern of each of these proteins distinctly in the cell nucleus via immunocytochemistry and confocal microscopy. Adult stem cell cardiomyogenesis remains a precarious process. I developed a reproducible bone marrow stem cell isolation and differentiation protocol to further investigate the presence of these proteins in nuclei of multipotent, bone marrow-derived mesenchymal stem cells from adult rats. I investigated the temporal appearance of cardiac genes and structural proteins in bone marrow stem cells undergoing cardiomyogenesis. Using my permeabilization and extraction protocol, I investigated the presence of nuclear actin, cTnC, cTnI, cTnT and cTm in the nuclei of both ventricular cardiomyocytes and undifferentiated, multipotent BM-MSCs and in BM-MSCs treated to differentiate into cardiomyocytes. The efficacy of adult stem cells is known to be compromised as a function of age. This therefore raises questions about the effectiveness of autologous cell therapy in elderly patients. Using a rodent model, I investigated and showed that there are differences in BM-MSCs associated with the age of the animal from which the cells are isolated.

A Thesis submitted to the Department of Biological Science in partial fulfillment of the requirements for the degree of Master of Science.

Spring Semester, 2012.

March 15, 2012.

Actin, Cardiac Myocytes, Nucleus, Stem Cells, Tropomyosin, Troponin

Bryant Chase, Professor Directing Thesis; Thomas Keller, Committee Member; Paul Trombley, Committee Member.

Advisors/Committee Members: Bryant Chase (professor directing thesis), Thomas Keller (committee member), Paul Trombley (committee member).

Subjects/Keywords: Biology; Life sciences

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Asumda, F. Z. (2012). Nuclear Cardiac Troponins, Tropomyosin and Actin in Native Ventricular Cardiomyocytes. (Masters Thesis). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-4698 ;

Chicago Manual of Style (16^th Edition):

Asumda, Faizal Z. “Nuclear Cardiac Troponins, Tropomyosin and Actin in Native Ventricular Cardiomyocytes.” 2012. Masters Thesis, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-4698 ;.

MLA Handbook (7^th Edition):

Asumda, Faizal Z. “Nuclear Cardiac Troponins, Tropomyosin and Actin in Native Ventricular Cardiomyocytes.” 2012. Web. 23 Jan 2021.

Vancouver:

Asumda FZ. Nuclear Cardiac Troponins, Tropomyosin and Actin in Native Ventricular Cardiomyocytes. [Internet] [Masters thesis]. Florida State University; 2012. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4698 ;.

Council of Science Editors:

Asumda FZ. Nuclear Cardiac Troponins, Tropomyosin and Actin in Native Ventricular Cardiomyocytes. [Masters Thesis]. Florida State University; 2012. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4698 ;

Florida State University

29. Buchanan, Amanda Lynn. Plant Responses to Joint Effects of Herbivores and Pollinators.

Degree: PhD, Biological Science, 2012, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4747 ;

► Plants are fed upon by a range of insect foragers, including herbivores and pollinators. Because herbivores damage plant parts and pollinators transfer pollen among plants,… (more)

▼ Plants are fed upon by a range of insect foragers, including herbivores and pollinators. Because herbivores damage plant parts and pollinators transfer pollen among plants, plants generally benefit by avoiding herbivores and attracting pollinators. Through interactions with their host plants, herbivores and pollinators can influence the expression and evolution of plant traits. While there is a substantial body of research on plant-herbivore and plant-pollinator interactions, and increasing appreciation for the joint effects of herbivores and pollinators on plants, there are still aspects of plant-pollinator-herbivore interactions that warrant attention, including the persistence of effects beyond the year in which the interaction occurred, the effects of variability in herbivory and pollination on the evolution of plant traits, and the effects of herbivores and pollinators on asexual reproduction in plants. Ecological interactions between foragers (pollinators and herbivores) and host plants make possible a network of feedbacks in which foragers both influence and respond to plant traits. These feedbacks can link the plant traits to which foragers respond, and thus may help explain observed variation in plant traits. Interactions among plants, herbivores, and pollinators have been well documented, but addressing interactions among all three across years in a single system is rare. Across year effects are particularly important because single-year studies might misinterpret plant responses to their environment. In chapter two I describe two experiments using the perennial plant Chamerion angustifolium that address plant-forager interactions. In one I manipulated herbivory and pollen receipt to quantify forager effects on plant traits and in another I manipulated plant size and flowering phenotype to quantify forager response. I found pathways of interaction between plants and insects both within and across years, suggesting the potential for feedback between foragers and plant traits. Results suggest that while pollinators prefer plants with more flowers, and pollen receipt results in smaller plants, herbivores cause size overcompensation and flower reduction. Together these effects of both herbivores and pollinators may help maintain intermediate values of size and flowering traits. Environmental conditions can have a profound influence on plant fitness, and can vary substantially in time. When environmental variability is unpredictable, that is, when plants have no cues as to upcoming environmental conditions, they should evolve a bet-hedging strategy to deal with environmental variability. In chapter three, I constructed a simulation model to address the evolution of the timing and pattern of resource allocation (allocation schedules) in annual and perennial plants under stochastic variability in herbivory and pollination. Both herbivory and pollination can be highly variable in space and time, but we don't fully understand how this variability influences the evolution of plant traits. I found that annual plants… Advisors/Committee Members: Nora Underwood (professor co-directing dissertation), Brian Inouye (professor co-directing dissertation), Paul Ruscher (university representative), Thomas E. Miller (committee member), Alice Winn (committee member).

Subjects/Keywords: Biology; Life sciences

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Buchanan, A. L. (2012). Plant Responses to Joint Effects of Herbivores and Pollinators. (Doctoral Dissertation). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-4747 ;

Chicago Manual of Style (16^th Edition):

Buchanan, Amanda Lynn. “Plant Responses to Joint Effects of Herbivores and Pollinators.” 2012. Doctoral Dissertation, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-4747 ;.

MLA Handbook (7^th Edition):

Buchanan, Amanda Lynn. “Plant Responses to Joint Effects of Herbivores and Pollinators.” 2012. Web. 23 Jan 2021.

Vancouver:

Buchanan AL. Plant Responses to Joint Effects of Herbivores and Pollinators. [Internet] [Doctoral dissertation]. Florida State University; 2012. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4747 ;.

Council of Science Editors:

Buchanan AL. Plant Responses to Joint Effects of Herbivores and Pollinators. [Doctoral Dissertation]. Florida State University; 2012. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-4747 ;

Florida State University

30. Schellinger, Jennifer. Hardbottom Sessile Macroinvertebrate Communities of the Apalachee Bay Region of Florida's Northeastern Gulf of Mexico.

Degree: MS, Biological Science, 2013, Florida State University

URL: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7595 ;

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Hardbottom habitats in the northeastern Gulf of Mexico provide a variety of valuable ecological goods and services including functioning as nursery habitats and providing refuge… (more)

Subjects/Keywords: Biology; Life sciences

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APA (6^th Edition):

Schellinger, J. (2013). Hardbottom Sessile Macroinvertebrate Communities of the Apalachee Bay Region of Florida's Northeastern Gulf of Mexico. (Masters Thesis). Florida State University. Retrieved from http://purl.flvc.org/fsu/fd/FSU_migr_etd-7595 ;

Chicago Manual of Style (16^th Edition):

Schellinger, Jennifer. “Hardbottom Sessile Macroinvertebrate Communities of the Apalachee Bay Region of Florida's Northeastern Gulf of Mexico.” 2013. Masters Thesis, Florida State University. Accessed January 23, 2021. http://purl.flvc.org/fsu/fd/FSU_migr_etd-7595 ;.

MLA Handbook (7^th Edition):

Schellinger, Jennifer. “Hardbottom Sessile Macroinvertebrate Communities of the Apalachee Bay Region of Florida's Northeastern Gulf of Mexico.” 2013. Web. 23 Jan 2021.

Vancouver:

Schellinger J. Hardbottom Sessile Macroinvertebrate Communities of the Apalachee Bay Region of Florida's Northeastern Gulf of Mexico. [Internet] [Masters thesis]. Florida State University; 2013. [cited 2021 Jan 23]. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7595 ;.

Council of Science Editors:

Schellinger J. Hardbottom Sessile Macroinvertebrate Communities of the Apalachee Bay Region of Florida's Northeastern Gulf of Mexico. [Masters Thesis]. Florida State University; 2013. Available from: http://purl.flvc.org/fsu/fd/FSU_migr_etd-7595 ;

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