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You searched for subject:(Bifunctionalization). Showing records 1 – 3 of 3 total matches.

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Universitat Ramon Llull

1. Llinàs Riera, Maria del Carme. New functionalization methodologies of mesoporous silica nanoparticles (MSNs) for biomedical applications.

Degree: 2016, Universitat Ramon Llull

In this PhD dissertation, a general procedure for the obtaining of different regioselective orthogonal bifunctionalized mesoporous silica nanoparticles (MSNs) has been carried out. The strategy consists of a covalent functionalization of co-condensed monodispersed and uniform aminated-MSNs, where tensioactive is still present in its structure. Three bifunctionalized MSNs, amine-azide (MSN-(NH2)i(N3)o), amine-isothiocyanate (MSN-(NH2)i(NCS)o) and amine-aldehyde (MSN-(NH2)i(CHO)o), with efficient “click” reactions, have been synthetized for its use in biomedical applications. First, a well characterized batch of precursor aminated-MSNs (MSN-(NH2)) has been prepared. The best conditions for the synthesis of homogenous and reproducible MSN-(NH2) with a size between 50-100 nm have been studied. These aminated-MSNs have been used for the synthesis of naphthalimide sensors where a general procedure for the introduction of 4-amine-1,8-naphthalimides has been developed. These naphthalimides have been tested as potential logic gates for the detection of H+ and F-. A straightforward protocol to prepare amine-azide MSNs has been described. These MSNs have been functionalized with quinolin cationic foldamers for the first time. The ability of these foldamer-MSNs to cross cytoplasmic membranes and its viability has been studied. The penetrating capacity of foldamer-MSNs have been used for intracellular delivery of Doxorubicin (DOX). A new protocol to prepare isothiocyanate functionalized MSNs is described. The synthetic methodology is general and can be applied, in principle, to all type of aminated MSNs. The efficiency of the functionalization is comparable to the copper cycloaddition (CuAAC) avoiding isolation and copper removal protocols. Following this methodology, new amino-isothiocyanate-MSNs have been prepared for the design of a nano-container able to release the drug Ataluren in a controlled manner, for the treatment of Duchenne muscular dystrophy (DMD). Regioselective bifunctionalized amine-aldehyde-MSNs have been synthetized. These MSNs have been applied as a versatile nanoplatform able to release dual synergistic CPT/DOX mixture for cancer treatment only by using pH stimuli. While CPT is absorbed at the inner surface, DOX is covalently linked to the external surface acting both as an active and a capping agent (pH=4). Advisors/Committee Members: Universitat Ramon Llull. IQS SE - Química Orgànica i Farmacèutica (2015 - ), [email protected] (authoremail), true (authoremailshow), Sánchez García, David (director), true (authorsendemail).

Subjects/Keywords: Mesoporous silica nanoparticles; Regioselective bifunctionalization; Drug delivery; Anion Sensing; Nanotechnology; Biomedicine; Ciències; 54; 547

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Llinàs Riera, M. d. C. (2016). New functionalization methodologies of mesoporous silica nanoparticles (MSNs) for biomedical applications. (Thesis). Universitat Ramon Llull. Retrieved from http://hdl.handle.net/10803/369849

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Llinàs Riera, Maria del Carme. “New functionalization methodologies of mesoporous silica nanoparticles (MSNs) for biomedical applications.” 2016. Thesis, Universitat Ramon Llull. Accessed January 20, 2021. http://hdl.handle.net/10803/369849.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Llinàs Riera, Maria del Carme. “New functionalization methodologies of mesoporous silica nanoparticles (MSNs) for biomedical applications.” 2016. Web. 20 Jan 2021.

Vancouver:

Llinàs Riera MdC. New functionalization methodologies of mesoporous silica nanoparticles (MSNs) for biomedical applications. [Internet] [Thesis]. Universitat Ramon Llull; 2016. [cited 2021 Jan 20]. Available from: http://hdl.handle.net/10803/369849.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Llinàs Riera MdC. New functionalization methodologies of mesoporous silica nanoparticles (MSNs) for biomedical applications. [Thesis]. Universitat Ramon Llull; 2016. Available from: http://hdl.handle.net/10803/369849

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Radi, Abdullah. Nanochemistry on Si(100): Surface Biofunctionalization by Amino-containing Bifunctional Molecules, and Shape Control of Copper Core-Shell Nanoparticles.

Degree: 2009, University of Waterloo

The present research involves two projects: a surface science study of the room-temperature adsorption and thermal evolution of allylamine and ethanolamine on Si(100)2×1, studied by using temperature-dependent X-ray photoelectron spectroscopy (XPS) and thermal desorption spectrometry (TDS), as well as Density Functional Theory (DFT) calculations; and a materials science study on the shape control of copper nanoparticles (Cu NPs) deposited on H-terminated Si(100) substrate with an extended size regime of 5-400 nm, by using a simple, one-step electrochemical method. The Cu NPs of three primary shapes were characterized with scanning-electron microscopy (SEM), glancing-incidence X-ray diffraction (GIXRD) and XPS. In the first surface science study, the presence of broad N 1s XPS features at 398.9-399.1 eV, corresponding to N–Si bonds, indicates N–H dissociative adsorption for both allylamine and ethanolamine on Si(100)2×1. For allylamine, the presence of C 1s features at 284.6 eV and 286.2 eV, corresponding to C=C and C−N, respectively, and the absence of the Si−C feature expected at 283.5 eV show that the reactions involving the ethenyl group such as the [2+2] C=C cycloaddition or those producing the [N, C, C] tridentate adstructures do not occur at room temperature. For ethanolamine, the O 1s feature at 533.1 eV indicates the formation of Si−O bond and O−H dissociation, which confirms an [O, N] bidentate adstructure and excludes the N−H and O−H dissociation unidentate structures. These XPS data are consistent with the N−H unidentate, and N−H and O−H double dissociation [O, N] bidentate adstructures for allylamine and ethanolamine, respectively, as predicted by the DFT calculations. TDS and temperature-dependent XPS data further show the desorption of propene and ethylene at 580 K and of acetylene at 700 K for allylamine and the desorption of ethylene at 615 K for ethanolamine, while the lack of N- or O-containing desorbates suggests that the dissociated N and O species are likely bonded to multiple surface Si atoms or diffused into the bulk at elevated temperatures (as confirmed by the corresponding temperature-dependent XPS spectra). Unlike the multidentate allyl alcohol and allylamine adstructures that have been found to be not favored kinetically, the present [O, N] bidentate ethanolamine adstructure appears to be kinetically favored on Si(100)2×1. In the second materials science study, Cu NPs of three primary shapes have been deposited on H-terminated Si(100) by a simple, one-step electrochemical method. By precisely manipulating the electrolyte concentration [CuSO4.5H2O] below their respective critical values, cubic, cuboctahedral, and octahedral Cu NPs of ranges of average sizes and number densities can be easily obtained by varying the deposition time. Combined GIXRD and depth-profiling XPS studies show that these Cu NPs have a crystalline core-shell structure, with a face-centered cubic metallic Cu core and a simple cubic Cu2O shell with a CuO outerlayer. The shape control of Cu NPs can be…

Subjects/Keywords: Nanochemistry; Copper Nanoparticles; Bifunctionalization; Allylamine; Ethanolamine; Silicon

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Radi, A. (2009). Nanochemistry on Si(100): Surface Biofunctionalization by Amino-containing Bifunctional Molecules, and Shape Control of Copper Core-Shell Nanoparticles. (Thesis). University of Waterloo. Retrieved from http://hdl.handle.net/10012/4560

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Radi, Abdullah. “Nanochemistry on Si(100): Surface Biofunctionalization by Amino-containing Bifunctional Molecules, and Shape Control of Copper Core-Shell Nanoparticles.” 2009. Thesis, University of Waterloo. Accessed January 20, 2021. http://hdl.handle.net/10012/4560.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Radi, Abdullah. “Nanochemistry on Si(100): Surface Biofunctionalization by Amino-containing Bifunctional Molecules, and Shape Control of Copper Core-Shell Nanoparticles.” 2009. Web. 20 Jan 2021.

Vancouver:

Radi A. Nanochemistry on Si(100): Surface Biofunctionalization by Amino-containing Bifunctional Molecules, and Shape Control of Copper Core-Shell Nanoparticles. [Internet] [Thesis]. University of Waterloo; 2009. [cited 2021 Jan 20]. Available from: http://hdl.handle.net/10012/4560.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Radi A. Nanochemistry on Si(100): Surface Biofunctionalization by Amino-containing Bifunctional Molecules, and Shape Control of Copper Core-Shell Nanoparticles. [Thesis]. University of Waterloo; 2009. Available from: http://hdl.handle.net/10012/4560

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Marie, Emilie. Synthèse d'imidazo (1,2-a) pyridines à activité antivirale à l'encontre des virus de l'hépatite C et de la diarrhée virale bovine : Synthesis of imidazo[1,2-a]pyridines with antiviral activity against hepatisis C and bovine viral diarrhea viruses.

Degree: Docteur es, Sciences de la vie et de la santé, spécialité Chimie thérapeutique, 2012, Université François-Rabelais de Tours

L’hépatite C est une maladie silencieuse, souvent asymptomatique, mais qui entraîne des lésions du foie et peut évoluer vers une cirrhose et, dans certains cas, vers un cancer. Le carcinome hépatocellulaire engendré par l’hépatite C constitue la première cause de transplantation hépatique. Les virus de l’hépatite C (VHC) et de la diarrhée virale bovine (VDVB) sont deux pestivirus possédant un ARN monocaténaire, de la famille des Flaviviridae. Bien qu’ayant des génomes différents, ils présentent une organisation structurelle et des processus de développement de l’enveloppe cellulaire comparables. Le screening de la chimiothèque du laboratoire a permis d’identifier cinq composés chefs de files, actifs à l’encontre du virus de l’hépatite C. Deux de ces composés de la série imidazo[1,2-a]pyridine ont fait l’objet d’un travail de pharmacomodulation dans le cadre des thèses de Jean-Baptiste Véron et Nicolas Henry. La première partie de mon travail de recherche a donc consisté à poursuivre ces travaux de pharmacomodulation afin de tenter d’améliorer l’activité de cette série chimique à l’égard du VHC ainsi que son index thérapeutique. La synthèse convergente de ces molécules a été effectuée grâce à des couplages métallo-catalysés.La seconde partie de mon projet de recherche a porté sur l’étude de la bifonctionnalisation des positions 7 et 8 du noyau imidazo[1,2-a]pyridine. Ces travaux ont permis de développer de nouvelles méthodologies pour introduire une diversité fonctionnelle sur ces positions. Ces molécules ont également été évaluées à l’encontre du VHC et l’une d’entre elle a montré une activité intéressante à l’encontre de ce virus. L’activité à l’encontre du VHC et l’index thérapeutique ont été améliorés pour deux molécules, analogues du BPIP.

Hepatitis C is a silent disease, often asymptomatic, responsible for hepatic lesions which may lead to cirrhosis and in some cases, to cancer. Hepatocellular carcinoma caused by hepatitis C virus is the leading cause of liver transplantation. Bovine viral diarrhoea (BVDV) and hepatitis C (HCV) viruses are two pestiviruses from the Flaviviridae family that have a single-stranded RNA. Despite having different genomes, they present a similar structural organization and processes of development of the cell envelope.The laboratory’s chemical library screening has identified five hits, active against the HCV. Two of these compounds from the imidazo[1,2-a]pyridine serie were pharmacomodulated as part of the Ph.D. thesis of Jean-Baptiste Véron and Nicolas Henry.The first part of my research work was therefore to continue the pharmacomodulation study of these chemical series to improve their activity against HCV and their therapeutic index. To do so, the convergent synthesis of these molecules was performed using metal-catalyzed couplings.The second part of my project has focused on the study of the difunctionalization of positions 7 and 8 of the imidazo[1,2-a]pyridine nucleus. This work helped to develop new methodologies for introducing a functional diversity on these positions.…

Advisors/Committee Members: Gueiffier, Alain (thesis director).

Subjects/Keywords: Hépatite C; VHC; VDVB; Imidazo[1,2-a]pyridine; Pharmacomodulation; Bifonctionnalisation; Couplages métallo-catalysés; Évaluation biologique; Hepatitis C; HCV; BVDV; Imidazo [1,2-a]pyridine; Pharmacomodulation; Bifunctionalization; Metallo-catalyzed cross-coupling; Biological evaluation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Marie, E. (2012). Synthèse d'imidazo (1,2-a) pyridines à activité antivirale à l'encontre des virus de l'hépatite C et de la diarrhée virale bovine : Synthesis of imidazo[1,2-a]pyridines with antiviral activity against hepatisis C and bovine viral diarrhea viruses. (Doctoral Dissertation). Université François-Rabelais de Tours. Retrieved from http://www.theses.fr/2012TOUR3802

Chicago Manual of Style (16th Edition):

Marie, Emilie. “Synthèse d'imidazo (1,2-a) pyridines à activité antivirale à l'encontre des virus de l'hépatite C et de la diarrhée virale bovine : Synthesis of imidazo[1,2-a]pyridines with antiviral activity against hepatisis C and bovine viral diarrhea viruses.” 2012. Doctoral Dissertation, Université François-Rabelais de Tours. Accessed January 20, 2021. http://www.theses.fr/2012TOUR3802.

MLA Handbook (7th Edition):

Marie, Emilie. “Synthèse d'imidazo (1,2-a) pyridines à activité antivirale à l'encontre des virus de l'hépatite C et de la diarrhée virale bovine : Synthesis of imidazo[1,2-a]pyridines with antiviral activity against hepatisis C and bovine viral diarrhea viruses.” 2012. Web. 20 Jan 2021.

Vancouver:

Marie E. Synthèse d'imidazo (1,2-a) pyridines à activité antivirale à l'encontre des virus de l'hépatite C et de la diarrhée virale bovine : Synthesis of imidazo[1,2-a]pyridines with antiviral activity against hepatisis C and bovine viral diarrhea viruses. [Internet] [Doctoral dissertation]. Université François-Rabelais de Tours; 2012. [cited 2021 Jan 20]. Available from: http://www.theses.fr/2012TOUR3802.

Council of Science Editors:

Marie E. Synthèse d'imidazo (1,2-a) pyridines à activité antivirale à l'encontre des virus de l'hépatite C et de la diarrhée virale bovine : Synthesis of imidazo[1,2-a]pyridines with antiviral activity against hepatisis C and bovine viral diarrhea viruses. [Doctoral Dissertation]. Université François-Rabelais de Tours; 2012. Available from: http://www.theses.fr/2012TOUR3802

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