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University of Alberta

1. Harasym, Anne C. Factors influencing glucose homeostasis in a rat model with mutated ATP synthase.

Degree: MS, Department of Agricultural, Food, and Nutritional Science, 2012, University of Alberta

This study examined glucose homeostasis mechanisms involved in the BHE/cdb rat model of mitochondrial diabetes with a mutated Fo subunit of ATP synthase. Twenty-one-week old male BHE/cdb rats exhibited enhanced glucose tolerance despite impaired insulin secretion. Whole body in vivo characterization showed that BHE/cdb rats had enhanced insulin sensitivity compared to controls, along with moderately increased (p<0.01) respiratory exchange ratios, oxygen consumption, carbon dioxide production and heat production, despite similar relative body composition, physical activity, food and water consumption. In vitro markers of insulin-dependent and insulin-independent signaling pathways were similar in BHE/cdb rats and controls. Phosphoenolpyruvate carboxykinase expression in liver (p<0.05), liver glycogen storage (p<0.05), and epitrochlearis muscle glycogen (p<0.01) were increased in BHE/cdb rats. Additionally, in vivo pyruvate-stimulated gluconeogenesis was attenuated in BHE/cdb rats (p<0.01). Results indicate that increased glucose oxidation, increased thermogenesis, and reduced hepatic glucose output mediate glucose tolerance in the BHE/cdb model.

Subjects/Keywords: mitochondrial diabetes; gluconeogenesis; glucose tolerance; BHE/cdb

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Harasym, A. C. (2012). Factors influencing glucose homeostasis in a rat model with mutated ATP synthase. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/1v53jx28q

Chicago Manual of Style (16th Edition):

Harasym, Anne C. “Factors influencing glucose homeostasis in a rat model with mutated ATP synthase.” 2012. Masters Thesis, University of Alberta. Accessed December 09, 2019. https://era.library.ualberta.ca/files/1v53jx28q.

MLA Handbook (7th Edition):

Harasym, Anne C. “Factors influencing glucose homeostasis in a rat model with mutated ATP synthase.” 2012. Web. 09 Dec 2019.

Vancouver:

Harasym AC. Factors influencing glucose homeostasis in a rat model with mutated ATP synthase. [Internet] [Masters thesis]. University of Alberta; 2012. [cited 2019 Dec 09]. Available from: https://era.library.ualberta.ca/files/1v53jx28q.

Council of Science Editors:

Harasym AC. Factors influencing glucose homeostasis in a rat model with mutated ATP synthase. [Masters Thesis]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/1v53jx28q

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