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You searched for subject:(B thalassemia). Showing records 1 – 2 of 2 total matches.

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1. van Straaten, H.A.S. Unraveling hereditary hemolytic anemia: Clinical sequelae and pathophysiology.

Degree: 2019, University Utrecht

This thesis was designed to contribute to unraveling various aspects of hereditary hemolytic anemia (HHA), and to outline the first steps towards creating an evidence based framework for future guidelines regarding diagnosis and treatment of HHA. In the first part of the thesis we focused on the clinical burden of HHA. For this we describe quality of life of patients with HHA, as well as organ involvement. including the rare, but dangerous complication pulmonary hypertension. The second part of the thesis was dedicated to the association between clinical symptoms and pathophysiology. For this we studied the relation between hypercoagulability after splenectomy and cell derived membrane enclosed PS-exposing extracellular vesicles. Second, we studied the role of the currently not fully understood elevated levels of red cell 2,3-diphopshoglycerate (2,3-DPG) in SCD and their relation to oxidative stress. In the last part of this thesis we evaluated current diagnostic and treatment strategies for HHA. For this we studied occurence of iron overload, and evaluated the effectiveness of currently used guidelines to diagnose iron overload. Lastly, we describe an inventory of stem cell transplantation as a treatment for pyruvate kinase deficiency. Advisors/Committee Members: van Solinge, W.W., Schutgens, REG, van Beers, Eduard, van Wijk, Richard.

Subjects/Keywords: sickle cell disease; pyruvate kinase deficiency; hereditary spherocytosis; B-thalassemia; splenectomy; extracelullar vesicles; hereditary hemolytic anemia

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APA (6th Edition):

van Straaten, H. A. S. (2019). Unraveling hereditary hemolytic anemia: Clinical sequelae and pathophysiology. (Doctoral Dissertation). University Utrecht. Retrieved from http://dspace.library.uu.nl/handle/1874/377327 ; URN:NBN:NL:UI:10-1874-377327 ; urn:isbn:978-94-6182-930-6 ; URN:NBN:NL:UI:10-1874-377327 ; http://dspace.library.uu.nl/handle/1874/377327

Chicago Manual of Style (16th Edition):

van Straaten, H A S. “Unraveling hereditary hemolytic anemia: Clinical sequelae and pathophysiology.” 2019. Doctoral Dissertation, University Utrecht. Accessed December 08, 2019. http://dspace.library.uu.nl/handle/1874/377327 ; URN:NBN:NL:UI:10-1874-377327 ; urn:isbn:978-94-6182-930-6 ; URN:NBN:NL:UI:10-1874-377327 ; http://dspace.library.uu.nl/handle/1874/377327.

MLA Handbook (7th Edition):

van Straaten, H A S. “Unraveling hereditary hemolytic anemia: Clinical sequelae and pathophysiology.” 2019. Web. 08 Dec 2019.

Vancouver:

van Straaten HAS. Unraveling hereditary hemolytic anemia: Clinical sequelae and pathophysiology. [Internet] [Doctoral dissertation]. University Utrecht; 2019. [cited 2019 Dec 08]. Available from: http://dspace.library.uu.nl/handle/1874/377327 ; URN:NBN:NL:UI:10-1874-377327 ; urn:isbn:978-94-6182-930-6 ; URN:NBN:NL:UI:10-1874-377327 ; http://dspace.library.uu.nl/handle/1874/377327.

Council of Science Editors:

van Straaten HAS. Unraveling hereditary hemolytic anemia: Clinical sequelae and pathophysiology. [Doctoral Dissertation]. University Utrecht; 2019. Available from: http://dspace.library.uu.nl/handle/1874/377327 ; URN:NBN:NL:UI:10-1874-377327 ; urn:isbn:978-94-6182-930-6 ; URN:NBN:NL:UI:10-1874-377327 ; http://dspace.library.uu.nl/handle/1874/377327


Université de Montréal

2. Felfly, Hady. Development of cellular and gene therapies for b[beta]-Thalassemia and sickle cell disease .

Degree: 2008, Université de Montréal

Subjects/Keywords: B-thalassémie; B-thalassemia; Drépanocytose; Sickle cell disease (SCD); Érythropoïèse; Erythropoiesis; Hémoglobine; Hemoglobin; Globule rouge; Red blood cell; Transplantation de moelle osseuse; Bone marrow transplantation; Chimère; Chimera; Thérapie cellulaire; Cellular therapy; Thérapie génique; Gene therapy

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Felfly, H. (2008). Development of cellular and gene therapies for b[beta]-Thalassemia and sickle cell disease . (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/6615

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Felfly, Hady. “Development of cellular and gene therapies for b[beta]-Thalassemia and sickle cell disease .” 2008. Thesis, Université de Montréal. Accessed December 08, 2019. http://hdl.handle.net/1866/6615.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Felfly, Hady. “Development of cellular and gene therapies for b[beta]-Thalassemia and sickle cell disease .” 2008. Web. 08 Dec 2019.

Vancouver:

Felfly H. Development of cellular and gene therapies for b[beta]-Thalassemia and sickle cell disease . [Internet] [Thesis]. Université de Montréal; 2008. [cited 2019 Dec 08]. Available from: http://hdl.handle.net/1866/6615.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Felfly H. Development of cellular and gene therapies for b[beta]-Thalassemia and sickle cell disease . [Thesis]. Université de Montréal; 2008. Available from: http://hdl.handle.net/1866/6615

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.