subject:(Aza peptide)

Vanderbilt University

1. Schwieter, Kenneth Edward. Toward On-Demand Peptide Synthesis: Development and Application of Enantioselective Syntheses of Unnatural α-Amino Amides.

Degree: PhD, Chemistry, 2016, Vanderbilt University

URL: http://hdl.handle.net/1803/14372

► Unnatural amino acid derived fragments are present in a multitude of pharmaceuticals and biologically relevant molecules including complex peptides. Current preparative methods focus almost entirely… (more)

Subjects/Keywords: peptide synthesis; umpolung; amide synthesis; amino acids; aza-Henry; organocatalysis

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APA (6^th Edition):

Schwieter, K. E. (2016). Toward On-Demand Peptide Synthesis: Development and Application of Enantioselective Syntheses of Unnatural α-Amino Amides. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14372

Chicago Manual of Style (16^th Edition):

Schwieter, Kenneth Edward. “Toward On-Demand Peptide Synthesis: Development and Application of Enantioselective Syntheses of Unnatural α-Amino Amides.” 2016. Doctoral Dissertation, Vanderbilt University. Accessed January 26, 2021. http://hdl.handle.net/1803/14372.

MLA Handbook (7^th Edition):

Schwieter, Kenneth Edward. “Toward On-Demand Peptide Synthesis: Development and Application of Enantioselective Syntheses of Unnatural α-Amino Amides.” 2016. Web. 26 Jan 2021.

Vancouver:

Schwieter KE. Toward On-Demand Peptide Synthesis: Development and Application of Enantioselective Syntheses of Unnatural α-Amino Amides. [Internet] [Doctoral dissertation]. Vanderbilt University; 2016. [cited 2021 Jan 26]. Available from: http://hdl.handle.net/1803/14372.

Council of Science Editors:

Schwieter KE. Toward On-Demand Peptide Synthesis: Development and Application of Enantioselective Syntheses of Unnatural α-Amino Amides. [Doctoral Dissertation]. Vanderbilt University; 2016. Available from: http://hdl.handle.net/1803/14372

Georgia Tech

2. Campbell, Amy. Design, Synthesis, and Evaluation of Cysteine Protease Inhibitors.

Degree: PhD, Chemistry and Biochemistry, 2005, Georgia Tech

URL: http://hdl.handle.net/1853/14046

► Both clan CA and clan CD proteases have a variety of physiological and pathological roles. In particular, both clans have members who have been implicated… (more)

▼ Both clan CA and clan CD proteases have a variety of physiological and pathological roles. In particular, both clans have members who have been implicated in cell death pathways, including apoptosis. Caspases are members of clan CD. Many of the caspase inhibitors used in apoptotic studies have shown cross reactivity with clan CA proteases. Thus, the anti-apoptotic effect of these inhibitors could be due to the broad-spectrum inhibition of a variety of cysteine proteases. Recently, the Powers laboratory designed a new class of inhibitors highly specific for clan CD proteases, aza-peptide epoxides. Initial data showed that this high selectivity could be due to the presence of the aza-residue, and not simply an artifact of substrate specificities. E-64c, an epoxysuccinyl inhibitor, is known to be a highly potent inhibitor of cathepsin B and calpain I. Thus, to determine if these clan CA proteases could tolerate an aza-residue, aza-E-64c and its analogues were synthesized. These inhibitors, termed epoxysuccinyl aza-peptides, were found to be significantly less potent for cathepsin B, calpain I, and papain than their non-aza counterparts, including E-64c. Previous findings have shown that the reactivity and selectivity of aza-peptide epoxides with caspases were significantly influenced by epoxide stereochemistry and the prime side substituent. Thus, this second project involved the systematic study of epoxide stereochemistry effects, prime side substituent effects, and the combined effect of these two variables. All inhibitors were tested with the seven apoptotic caspases: caspases-2, -3, -6, -7, -8, -9, and -10. We found that epoxide stereochemistry, prime side substituent, and also the peptidyl sequence have combined effects on potency and selectivity. In general, the (S,S) stereoisomer is the most potent relative to the (R,R) and (cis) stereochemistries. Modeling studies were done to determine why this is true. Aza-peptide epoxides were also briefly compared to aza-peptide Michael acceptors, another class of inhibitors highly specific for clan CD proteases Advisors/Committee Members: Powers, James (Committee Chair), Doyle, Donald (Committee Member), Fahrni, Christoph (Committee Member), May, Sheldon (Committee Member), Murthy, Niren (Committee Member).

Subjects/Keywords: Epoxysuccinyl aza-peptides; Molecular modeling; Caspases; Irreversible kinetics; Aza-peptide epoxides

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Campbell, A. (2005). Design, Synthesis, and Evaluation of Cysteine Protease Inhibitors. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/14046

Chicago Manual of Style (16^th Edition):

Campbell, Amy. “Design, Synthesis, and Evaluation of Cysteine Protease Inhibitors.” 2005. Doctoral Dissertation, Georgia Tech. Accessed January 26, 2021. http://hdl.handle.net/1853/14046.

MLA Handbook (7^th Edition):

Campbell, Amy. “Design, Synthesis, and Evaluation of Cysteine Protease Inhibitors.” 2005. Web. 26 Jan 2021.

Vancouver:

Campbell A. Design, Synthesis, and Evaluation of Cysteine Protease Inhibitors. [Internet] [Doctoral dissertation]. Georgia Tech; 2005. [cited 2021 Jan 26]. Available from: http://hdl.handle.net/1853/14046.

Council of Science Editors:

Campbell A. Design, Synthesis, and Evaluation of Cysteine Protease Inhibitors. [Doctoral Dissertation]. Georgia Tech; 2005. Available from: http://hdl.handle.net/1853/14046

3. Besret, Soizic. Ligations chimiques : synthèse d'inhibiteurs extracellulaires de la signalisation HGF/SF-MET : Chemical Ligation Synthesis of extracellular inhibitors of HGF/SF-MET signalling pathway.

Degree: Docteur es, Sciences du médicament, 2011, Université Lille II – Droit et Santé

URL: http://www.theses.fr/2011LIL2S003

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Les peptides constituent une famille de biomolécules dont l’utilisation dans différents domaines thérapeutiques (cancer, diabète, sida) s’est fortement développée ces dernières années. Le défi pour… (more)

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Les peptides constituent une famille de biomolécules dont l’utilisation dans différents domaines thérapeutiques (cancer, diabète, sida) s’est fortement développée ces dernières années. Le défi pour les chimistes consiste à y accéder grâce à de nouvelles méthodes fiables et efficaces. La première partie de notre travail a d’abord été orientée vers le développement deux méthodes de ligations non natives efficaces et complémentaires de celles existant. La première méthode, appelée ligation thiocarbamate, permet d’obtenir des peptides alkylthiocarbamate avec de très bons rendements, alors que la seconde, appelée ligation azaGly, aboutit à la formation d’un azaGlypeptide. La seconde partie de cette thèse traite de la conception et synthèse de nouveaux peptides susceptibles d’inhiber la signalisation HGF/SF-MET. Le récepteur à activité tyrosine kinase MET et son ligand, l’HGF/SF (Hepatocyte Growth Factor/Scattor Factor), sont des cibles de choix pour une thérapie anti-cancéreuse. La ligation thiocarbamate, précédemment décrite, et la ligation thioéther plus classique ont été utilisées pour préparer une chimiothèque de peptides sulfonatés d’inhiber cette signalisation de façon extracellulaire. La capacité de liaison des composés de la chimiothèque avec le domaine extracellulaire de MET a été évaluée grâce à la technologie biopuces. L’activité biologique (tests MTT, d’activité kinase) des meilleurs produits a été ensuite évaluée.

Use of peptides as biomolecules have been extensively applied to various therapeutic fields (cancer, diabetes, AIDS). The challenge for chemists consists in development of new reliable and efficient strategies. Our work especially focused on the conception of two innovative non native chemical ligations bringing an additionnal asset to the existing state of the art.The first ligation, i.e. thiocarbamate ligation, affords alkylthiocarbamate peptides with remarkable yields. Regarding the second one, the azaGly ligation allows the straightforward synthesis of azaGlypeptides. On the other hand, this thesis deals with the design of new peptides suitable to inhibit the signaling pathway of the tyrosine–kinase MET receptor and its ligand HGF/SF (Hepatocyte Growth factor/Scattor factor). Indeed interfering with MET signaling appears to be a promising therapeutic approach.The thiocarbamate ligation disclosed previously along with a classical thioether ligation have been employed for the chemical library design of sulfonated peptids in order to inhibit extracellular interactions. Binding activities assessment of the chemical libray toward the MET extracellular domain has been achieved using a microarray technology. Biological activities (MTT tests and kinase activity) have also been investigated.

Advisors/Committee Members: Melnyk, Oleg (thesis director), Melnyk, Patricia (thesis director).

Subjects/Keywords: Ligations chimiques; Ligations peptidiques; Aza Glypeptide; Inhibiteurs de MET; Proto Oncogene Proteins c met; Peptide Library

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Besret, S. (2011). Ligations chimiques : synthèse d'inhibiteurs extracellulaires de la signalisation HGF/SF-MET : Chemical Ligation Synthesis of extracellular inhibitors of HGF/SF-MET signalling pathway. (Doctoral Dissertation). Université Lille II – Droit et Santé. Retrieved from http://www.theses.fr/2011LIL2S003

Chicago Manual of Style (16^th Edition):

Besret, Soizic. “Ligations chimiques : synthèse d'inhibiteurs extracellulaires de la signalisation HGF/SF-MET : Chemical Ligation Synthesis of extracellular inhibitors of HGF/SF-MET signalling pathway.” 2011. Doctoral Dissertation, Université Lille II – Droit et Santé. Accessed January 26, 2021. http://www.theses.fr/2011LIL2S003.

MLA Handbook (7^th Edition):

Besret, Soizic. “Ligations chimiques : synthèse d'inhibiteurs extracellulaires de la signalisation HGF/SF-MET : Chemical Ligation Synthesis of extracellular inhibitors of HGF/SF-MET signalling pathway.” 2011. Web. 26 Jan 2021.

Vancouver:

Besret S. Ligations chimiques : synthèse d'inhibiteurs extracellulaires de la signalisation HGF/SF-MET : Chemical Ligation Synthesis of extracellular inhibitors of HGF/SF-MET signalling pathway. [Internet] [Doctoral dissertation]. Université Lille II – Droit et Santé 2011. [cited 2021 Jan 26]. Available from: http://www.theses.fr/2011LIL2S003.

Council of Science Editors:

Besret S. Ligations chimiques : synthèse d'inhibiteurs extracellulaires de la signalisation HGF/SF-MET : Chemical Ligation Synthesis of extracellular inhibitors of HGF/SF-MET signalling pathway. [Doctoral Dissertation]. Université Lille II – Droit et Santé 2011. Available from: http://www.theses.fr/2011LIL2S003

Vanderbilt University

4. Makley, Dawn Marie. Umpolung amide synthesis: applications in enantioselective peptide synthesis.

Degree: PhD, Chemistry, 2012, Vanderbilt University

URL: http://hdl.handle.net/1803/14598

► UMPOLUNG AMIDE SYNTHESIS: APPLICATIONS IN ENANTIOSELECTIVE PEPTIDE SYNTHESISDAWN M. MAKLEYDissertation under the direction of Professor Jeffrey N. JohnstonThe development and application of the novel Umpolung… (more)

Subjects/Keywords: silyl imines; n-halo amines; natural product synthesis; peptide synthesis; amide synthesis; umpolung; methodology development; chemistry; aza-Henry; umpolung amide synthesis; UmAS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Makley, D. M. (2012). Umpolung amide synthesis: applications in enantioselective peptide synthesis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14598

Chicago Manual of Style (16^th Edition):

Makley, Dawn Marie. “Umpolung amide synthesis: applications in enantioselective peptide synthesis.” 2012. Doctoral Dissertation, Vanderbilt University. Accessed January 26, 2021. http://hdl.handle.net/1803/14598.

MLA Handbook (7^th Edition):

Makley, Dawn Marie. “Umpolung amide synthesis: applications in enantioselective peptide synthesis.” 2012. Web. 26 Jan 2021.

Vancouver:

Makley DM. Umpolung amide synthesis: applications in enantioselective peptide synthesis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2012. [cited 2021 Jan 26]. Available from: http://hdl.handle.net/1803/14598.

Council of Science Editors:

Makley DM. Umpolung amide synthesis: applications in enantioselective peptide synthesis. [Doctoral Dissertation]. Vanderbilt University; 2012. Available from: http://hdl.handle.net/1803/14598

Vanderbilt University

5. Shen, Bo. New Enantioselective Approaches to the Synthesis of Amino Acid Derivatives and Peptides Using Chiral Proton Catalysis.

Degree: PhD, Chemistry, 2010, Vanderbilt University

URL: http://hdl.handle.net/1803/11772

► α,β-Diamino acids and β-amino acids are important constituents in countless natural products. These atypical amino acids often display interesting and useful biological properties and have… (more)

▼ α,β-Diamino acids and β-amino acids are important constituents in countless natural products. These atypical amino acids often display interesting and useful biological properties and have also been used as useful building blocks for the synthesis of valuable pharmaceutical targets. This dissertation describes the application of chiral proton catalysis for the development of enantio- and diastereoselective aza-Henry reactions of nitroacetate pronucleophiles as a route towards α-nitro-β-amino acids. Direct reduction of the aza-Henry adducts afforded anti-α,β-diamino acid derivatives; alternatively, the post-addition epimerization/crystallization/reduction sequence generated syn-α,β-diamino acid derivatives. Following the aza-Henry reaction, denitration of the adducts provided β-amino acid derivatives with high ee, and this protocol was applied in the formal synthesis of (+)-chaenorhine. The amide functional group is one of Nature's key functional and structural elements, most notably within peptides. Amides are also key intermediates in the preparation of a diverse range of therapeutic small molecules. During the carbon-nitrogen bond forming step in most amide syntheses, the carbon and nitrogen bear electrophilic and nucleophilic character, respectively. The second half of the dissertation reveals the development of a novel method of amide bond formation deploying bromonitroalkanes and amines mediated by iodonium ion. Preliminary observations support a mechanistic construct in which reactant polarity is reversed (umpolung) during C-N bond formation relative to traditional approaches. This new approach leads to the development of an asymmetric aryl glycine amide synthesis without epimerization or extensive protection/deprotection schemes. And the first use of commercially available bromonitromethane in stereoselective peptide synthesis establishes a practical alternative to the longstanding reliance on the carboxylic acid feedstock. Advisors/Committee Members: Gary A. Sulikowski (committee member), Brian O. Bachmann (committee member), Charles M. Lukehart (committee member), Jeffrey N. Johnston (Committee Chair).

Subjects/Keywords: Chiral Proton Catalysis; Enantioselective; Amino Acid; Peptide synthesis; aza-Henry reaction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shen, B. (2010). New Enantioselective Approaches to the Synthesis of Amino Acid Derivatives and Peptides Using Chiral Proton Catalysis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/11772

Chicago Manual of Style (16^th Edition):

Shen, Bo. “New Enantioselective Approaches to the Synthesis of Amino Acid Derivatives and Peptides Using Chiral Proton Catalysis.” 2010. Doctoral Dissertation, Vanderbilt University. Accessed January 26, 2021. http://hdl.handle.net/1803/11772.

MLA Handbook (7^th Edition):

Shen, Bo. “New Enantioselective Approaches to the Synthesis of Amino Acid Derivatives and Peptides Using Chiral Proton Catalysis.” 2010. Web. 26 Jan 2021.

Vancouver:

Shen B. New Enantioselective Approaches to the Synthesis of Amino Acid Derivatives and Peptides Using Chiral Proton Catalysis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2010. [cited 2021 Jan 26]. Available from: http://hdl.handle.net/1803/11772.

Council of Science Editors:

Shen B. New Enantioselective Approaches to the Synthesis of Amino Acid Derivatives and Peptides Using Chiral Proton Catalysis. [Doctoral Dissertation]. Vanderbilt University; 2010. Available from: http://hdl.handle.net/1803/11772

Georgia Tech

6. Gotz, Marion Gabriele. Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases.

Degree: PhD, Chemistry and Biochemistry, 2004, Georgia Tech

URL: http://hdl.handle.net/1853/8072

► Cysteine proteases are a class of proteolytic enzymes, which are involved in a series of metabolic and catabolic processes, such as protein turnover, digestion, blood… (more)

▼ Cysteine proteases are a class of proteolytic enzymes, which are involved in a series of metabolic and catabolic processes, such as protein turnover, digestion, blood coagulation, apoptosis, fertilization and cell differentiation, and the immune response system. The development of novel potent and selective inhibitors for cysteine proteases has therefore gained increasing attention among medicinal chemists. In this thesis we have reported the design, synthesis, and evaluation of several peptidyl inhibitors for clan CA and clan CD cysteine proteases. We have continued the investigation of dipeptidyl vinyl sulfones as potent and selective inhibitors for dipeptidyl peptidase I (DPPI), a lysosomal cysteine protease, which is involved in the processing of intracellular proteases, such as granzymes. We have found that DPPI tolerates negatively charged amino acid residues in the P2 position with inhibition rates of 7,600 M-1s-1. Dipeptidyl vinyl sulfones with positively charged amino acid residues at the P1 position, however, do not inhibit DPPI at all. A second project focused on the epoxidation of the double bond of the vinyl sulfone moiety of the dipeptidyl vinyl sulfones. Instead of epoxidizing the double bond, we found that an isomerization had occurred. The newly formed compounds were determined to be allyl sulfones. We tested this new class of inhibitors with clan CA proteases and obtained inhibition rates of 560 M-1s-1 for Cbz-Leu-Phe-AS-Ph with calpain I. Two new classes of compounds for the clan CD protease S. mansoni legumain were designed, synthesized, and evaluated. Aza-peptidyl epoxides were found to be potent and selective inhibitors of S. mansoni legumain with IC50’s as low as 45 nM. Aza-peptide Michael acceptors were derived from the aza-peptide epoxide design and synthesized in an analogous fashion. The aza-peptide Michael acceptors inhibited S. mansoni legumain with even lower IC50’s, as low as 10 nM. However, the aza-peptide Michael acceptors react with thioalkylating agents contained in the buffer, such as DTT. The rates of degradation were determined spectroscopically, and half-lives of 3 to 20 minutes were measured. This observation gave us insights into the enzymatic mechanism and allowed us to determine the point of attack for the legumain active site cysteine thiol. Advisors/Committee Members: Dr. James C. Powers (Committee Chair), Dr. Donald Doyle, Dr. Nicholas Hud, Dr. Niren Murthy, and Dr. Suzanne Shuker (Committee Members).

Subjects/Keywords: Allyl sulfone; Aza-peptide; Biosynthesis; Cysteine protease; Cysteine proteinases; Irreversible inhibitors; Protease inhibitors; Sulphones; Vinyl sulfone

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gotz, M. G. (2004). Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/8072

Chicago Manual of Style (16^th Edition):

Gotz, Marion Gabriele. “Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases.” 2004. Doctoral Dissertation, Georgia Tech. Accessed January 26, 2021. http://hdl.handle.net/1853/8072.

MLA Handbook (7^th Edition):

Gotz, Marion Gabriele. “Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases.” 2004. Web. 26 Jan 2021.

Vancouver:

Gotz MG. Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases. [Internet] [Doctoral dissertation]. Georgia Tech; 2004. [cited 2021 Jan 26]. Available from: http://hdl.handle.net/1853/8072.

Council of Science Editors:

Gotz MG. Design, synthesis, and evaluation of irreversible peptidyl inhibitors for clan CA and clan CD cysteine proteases. [Doctoral Dissertation]. Georgia Tech; 2004. Available from: http://hdl.handle.net/1853/8072

7. Chingle, Ramesh. Design, synthesis, pericyclic chemistry and biomedical applications of azopeptides.

Degree: 2018, Université de Montréal

URL: http://hdl.handle.net/1866/20753

Subjects/Keywords: Azapeptides; Peptidomimétique; Tour β; Semicarbazone; Aza-valine; Semicarbazide; Azopeptide; Aza-Diels Alder; Alder-ene; Péricyclique; GHRP-6; Récepteur GHS-R1a; Récepteur CD36; Peptide mimicry; β-turn; Pericyclic; Chemistry - Organic / Chimie organique (UMI : 0490)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Chingle, R. (2018). Design, synthesis, pericyclic chemistry and biomedical applications of azopeptides. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/20753

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chingle, Ramesh. “Design, synthesis, pericyclic chemistry and biomedical applications of azopeptides.” 2018. Thesis, Université de Montréal. Accessed January 26, 2021. http://hdl.handle.net/1866/20753.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chingle, Ramesh. “Design, synthesis, pericyclic chemistry and biomedical applications of azopeptides.” 2018. Web. 26 Jan 2021.

Vancouver:

Chingle R. Design, synthesis, pericyclic chemistry and biomedical applications of azopeptides. [Internet] [Thesis]. Université de Montréal; 2018. [cited 2021 Jan 26]. Available from: http://hdl.handle.net/1866/20753.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chingle R. Design, synthesis, pericyclic chemistry and biomedical applications of azopeptides. [Thesis]. Université de Montréal; 2018. Available from: http://hdl.handle.net/1866/20753

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Montréal

8. Mohammadpourmir, Fatemeh. Synthesis of Aza- and α,α-disubstituted Glycinyl peptides and application of their electronic and steric interactions for controlling peptide folding, and for biomedical applications.

Degree: 2019, Université de Montréal

URL: http://hdl.handle.net/1866/21698

Subjects/Keywords: Peptidomimetic; Azapeptide; Prostaglandin F2alpha; Aza-propargylglycine; alpha-turn; gamma-turn; Cα-disubstituted glycine; peptide folding; 2-amino adamantane-2-carboxylic acid; torsion angle; Peptidomimétique; Prostaglandine F2alpha; Tour-alpha; Tour-beta; Tour-gamma; Acides aminés Calpha-di-substitués; Repliement peptidique; Acide-2-amino-2-adamantane; Angle de torsion; Chemistry - Organic / Chimie organique (UMI : 0490)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mohammadpourmir, F. (2019). Synthesis of Aza- and α,α-disubstituted Glycinyl peptides and application of their electronic and steric interactions for controlling peptide folding, and for biomedical applications. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/21698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mohammadpourmir, Fatemeh. “Synthesis of Aza- and α,α-disubstituted Glycinyl peptides and application of their electronic and steric interactions for controlling peptide folding, and for biomedical applications.” 2019. Thesis, Université de Montréal. Accessed January 26, 2021. http://hdl.handle.net/1866/21698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mohammadpourmir, Fatemeh. “Synthesis of Aza- and α,α-disubstituted Glycinyl peptides and application of their electronic and steric interactions for controlling peptide folding, and for biomedical applications.” 2019. Web. 26 Jan 2021.

Vancouver:

Mohammadpourmir F. Synthesis of Aza- and α,α-disubstituted Glycinyl peptides and application of their electronic and steric interactions for controlling peptide folding, and for biomedical applications. [Internet] [Thesis]. Université de Montréal; 2019. [cited 2021 Jan 26]. Available from: http://hdl.handle.net/1866/21698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mohammadpourmir F. Synthesis of Aza- and α,α-disubstituted Glycinyl peptides and application of their electronic and steric interactions for controlling peptide folding, and for biomedical applications. [Thesis]. Université de Montréal; 2019. Available from: http://hdl.handle.net/1866/21698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université de Montréal

9. Proulx, Caroline. Méthodologie pour la synthèse combinatoire d’azapeptides: application à la synthèse d’analogues aza-GHRP-6 en tant que ligands du récepteur CD36.

Degree: 2012, Université de Montréal

URL: http://hdl.handle.net/1866/8887

Subjects/Keywords: Azapeptides; Repliement beta; Mimes peptidiques; GHRP-6; Récepteur GHS-R1a; Récepteur CD36; Angiogénèse; Semicarbazone; N-Alkylation; N-Arylation; Aza-propargylglycine; Cycloaddition 1,3-dipolaire; Couplage A3; N-amino-imidazolin-2-ones; Beta turn; Peptide mimicry; GHS-R1a receptor; CD36 receptor; Angiogenesis; 1,3-Dipolar cycloaddition; A3 coupling; Chemistry - Organic / Chimie organique (UMI : 0490)

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Proulx, C. (2012). Méthodologie pour la synthèse combinatoire d’azapeptides: application à la synthèse d’analogues aza-GHRP-6 en tant que ligands du récepteur CD36. (Thesis). Université de Montréal. Retrieved from http://hdl.handle.net/1866/8887

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Proulx, Caroline. “Méthodologie pour la synthèse combinatoire d’azapeptides: application à la synthèse d’analogues aza-GHRP-6 en tant que ligands du récepteur CD36.” 2012. Thesis, Université de Montréal. Accessed January 26, 2021. http://hdl.handle.net/1866/8887.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Proulx, Caroline. “Méthodologie pour la synthèse combinatoire d’azapeptides: application à la synthèse d’analogues aza-GHRP-6 en tant que ligands du récepteur CD36.” 2012. Web. 26 Jan 2021.

Vancouver:

Proulx C. Méthodologie pour la synthèse combinatoire d’azapeptides: application à la synthèse d’analogues aza-GHRP-6 en tant que ligands du récepteur CD36. [Internet] [Thesis]. Université de Montréal; 2012. [cited 2021 Jan 26]. Available from: http://hdl.handle.net/1866/8887.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Proulx C. Méthodologie pour la synthèse combinatoire d’azapeptides: application à la synthèse d’analogues aza-GHRP-6 en tant que ligands du récepteur CD36. [Thesis]. Université de Montréal; 2012. Available from: http://hdl.handle.net/1866/8887

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations