subject:(Atrial fibrillation)

University of Zambia

1. Jere, Methuselah. Clinical factors associated with Atrial Fibrillation in congestive Heart Failure patients admitted at the University Teaching Hospital, Lusaka, Zambia .

Degree: 2015, University of Zambia

URL: http://dspace.unza.zm:8080/xmlui/handle/123456789/4398

► Introduction: Atrial fibrillation (AF) and congestive heart failure (CHF) have emerged as major global epidemics. These two conditions share common risk factors and frequently coexist.… (more)

▼ Introduction: Atrial fibrillation (AF) and congestive heart failure (CHF) have emerged as major global epidemics. These two conditions share common risk factors and frequently coexist. Each condition predisposes to the other, and the concomitant presence of the two has additive adverse effects. This study examined the clinical factors associated with AF in CHF patients admitted at the University Teaching Hospital (UTH), Lusaka, Zambia. Methods: A hospital-based cross-sectional study was conducted at UTH adult medical wards. The data and anthropometric measurements were collected from patients who consented for enrolment from June 2014 to August 2014. A structured interview schedule was used to capture the socio-demographic and related historical data; and an Omron HEM 780 automated Blood Pressure machine was used to measure Blood Pressure and pulse. Then all patients had a standard 12-lead ECG done on them using Schiller AT-102 ECG machine to detect the presence or absence of atrial fibrillation. Those participants whose standard 12-lead ECG results did not show the presence of AF, had 24-hours ECG DR180+ Digital Recorder applied to try to pick-up paroxysmal atrial fibrillation. Then finally all participants with any form of AF were assessed for clinical factors such as NYHA class, age, obesity, coronary heart disease, coexistence with non-cardiovascular diseases (e.g. chest diseases, diabetes mellitus), and smoking. Pearson chi-square of independence of the data was carried out using IBM® SPSS® Statistics for Windows version 20.0 to determine clinical factors of atrial fibrillation in congestive heart failure patients. Results: A total of 49 patients were included in the study and out of these, 13 (26.5%) had atrial fibrillation. The prevalence of atrial fibrillation in congestive heart failure was found to be strongly associated with age 65 years and above, obesity, smoking, excessive alcohol intake, hypertension, dilated cardiomyopathy, diabetes mellitus and chronic lung disease. These findings suggest the need for clinicians taking care of the congestive heart failure patients to consider full scale use of ambulatory ECG monitors in all congestive heart failure patients with the above conditions. Keywords: ECG DR180+ Digital Recorder, smoking, cardiomyopathy, diabetes, lung disease

Subjects/Keywords: Atrial Fibrillation; Atrial Fibrillation-Therapy; Heart Failure

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APA (6^th Edition):

Jere, M. (2015). Clinical factors associated with Atrial Fibrillation in congestive Heart Failure patients admitted at the University Teaching Hospital, Lusaka, Zambia . (Thesis). University of Zambia. Retrieved from http://dspace.unza.zm:8080/xmlui/handle/123456789/4398

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Jere, Methuselah. “Clinical factors associated with Atrial Fibrillation in congestive Heart Failure patients admitted at the University Teaching Hospital, Lusaka, Zambia .” 2015. Thesis, University of Zambia. Accessed July 22, 2019. http://dspace.unza.zm:8080/xmlui/handle/123456789/4398.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Jere, Methuselah. “Clinical factors associated with Atrial Fibrillation in congestive Heart Failure patients admitted at the University Teaching Hospital, Lusaka, Zambia .” 2015. Web. 22 Jul 2019.

Vancouver:

Jere M. Clinical factors associated with Atrial Fibrillation in congestive Heart Failure patients admitted at the University Teaching Hospital, Lusaka, Zambia . [Internet] [Thesis]. University of Zambia; 2015. [cited 2019 Jul 22]. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4398.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Jere M. Clinical factors associated with Atrial Fibrillation in congestive Heart Failure patients admitted at the University Teaching Hospital, Lusaka, Zambia . [Thesis]. University of Zambia; 2015. Available from: http://dspace.unza.zm:8080/xmlui/handle/123456789/4398

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

2. Schultz, Carlee Deanne. Thrombogenesis in substrates of atrial fibrillation.

Degree: 2014, University of Adelaide

URL: http://hdl.handle.net/2440/97880

► Background: Atrial Fibrillation (AF) is the most common atrial arrhythmia affecting Australia and the world, with patients with AF known to be at a 5times… (more)

▼ Background: Atrial Fibrillation (AF) is the most common atrial arrhythmia affecting Australia and the world, with patients with AF known to be at a 5times higher risk of stroke than that of the normal population. The substrates of AF are also known to significantly impact of this risk of stroke. Mitral stenosis (MS) is one of the leading causes of valvular AF in the developing world. Enlargement of the LA is one of the most common structural changes that occurs in MS and is known to lead to fibrosis and oxidative stress. These alterations can also cause atrial electrical remodelling leading to the development of AF. Patients with MS have been shown to have an increase in thrombogenic properties which include platelet reactivity, inflammation and endothelial dysfunction. The precise mechanisms which underlie this phenomenon of atrial thrombus formation in AF are still unknown, furthermore it is also unknown if the substrate (cause) of AF influences the thromboembolic profile in AF patients. This thesis aims to evaluate the peripheral and atrial thrombogenic profile of both AF and the major substrate MS and their differing disease states alter the thrombus potential. Methods: A total of 166 patients were collected for this study, 55 patients undergoing a radiofrequency ablation as a curative procedure for paroxysmal AF, at the Royal Adelaide Hospital, Adelaide, 59 patients with mitral stenosis (MS)undergoing a balloon valvuloplasty at the Christian Medical Centre in Vellore, India, and 52 with aged matched control subjects, diagnosed with left sided accessory pathway supraventricular tachycardia (SVT) undergoing a routine elective electrophysiological study. Blood samples were collected from the peripheral, RA and LA circulation, during each of these procedures, for further analysis through flow cytometry, platelet aggregation and ELISA tests. Echocardiographic studies were used for atrial structure measurements. Results: We found that within the AF population there is increase in thrombogenic markers within the heart compared to the peripheral circulation. More interestingly when comparing the MS and AF populations each of the different factors involved in thrombogenesis is altered differently, with AF having an increase in platelet reactivity and endothelial function (ADMA and ET-1) and inflammation through VCAM-1 and ICAM-1. However of inflammation through MPO, CD40L and IL-6 and structural remodelling (MMP-9 and TIMP-1) were more pronounced within the MS population. Conclusion: This study has shown that AF and the valvular AF substrate mitral stenosis (MS) have two distinctly different mechanisms leading to atrial thrombus formation. This shows that MS as a substrate for valvular AF impacts on atrial thrombus formation through remodelling and inflammation whereas non valvular AF affects endothelial function and tissue inflammation. This illustrates that the pathophysiology of each of the diseases states is different when comparing it to the normal haemostatic properties of the heart within a control (SVT)… Advisors/Committee Members: Willoughby, Scott Richard (advisor), Brooks, Anthony Graham (advisor), John, Bobby (advisor), Gasean, Anand (advisor), Sanders, Prash (advisor), School of Medicine (school).

Subjects/Keywords: thrombogenesis; atrial fibrillation

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APA (6^th Edition):

Schultz, C. D. (2014). Thrombogenesis in substrates of atrial fibrillation. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/97880

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schultz, Carlee Deanne. “Thrombogenesis in substrates of atrial fibrillation.” 2014. Thesis, University of Adelaide. Accessed July 22, 2019. http://hdl.handle.net/2440/97880.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schultz, Carlee Deanne. “Thrombogenesis in substrates of atrial fibrillation.” 2014. Web. 22 Jul 2019.

Vancouver:

Schultz CD. Thrombogenesis in substrates of atrial fibrillation. [Internet] [Thesis]. University of Adelaide; 2014. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/2440/97880.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schultz CD. Thrombogenesis in substrates of atrial fibrillation. [Thesis]. University of Adelaide; 2014. Available from: http://hdl.handle.net/2440/97880

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

3. Pathik, Manaswi Bhupesh. New insights into the mechanisms of atrial arrhythmias using novel three dimensional mapping techniques.

Degree: 2017, University of Melbourne

URL: http://hdl.handle.net/11343/194696

► Advances in our understanding of the pathophysiology of atrial fibrillation (AF) and atrial macro-reentry through improvements in technology has led to the development of treatment… (more)

▼ Advances in our understanding of the pathophysiology of atrial fibrillation (AF) and atrial macro-reentry through improvements in technology has led to the development of treatment approaches involving catheter ablation. However, outcomes have been suboptimal possibly due to an incomplete understanding of the underlying mechanisms of these arrhythmias. Using novel three-dimensional (3D) mapping techniques, this thesis aims to answer unresolved questions in our understanding of the mechanisms of human persistent AF and atrial macro-reentry. Recent work using phase mapping has suggested that rotors may act as drivers for persistent AF with studies from different centers reporting promising findings of acute termination and long term freedom from AF with ablation at the rotor center. However, these encouraging results have not been observed consistently possibly due to the two-dimensional (2D) representation of the left atrium (LA) in this mapping technique. In Chapter 2, we used a novel 3D phase mapping technology that takes into account patient-specific left atrial geometry to display phase to determine the dominant propagation patterns in patients with persistent AF. We observed transient rotors in the majority of patients, however, they were present for only a small fraction of the total recording time with the dominant propagation pattern overall being single broad wavefronts. An additional assumption of the abovementioned 2D phase mapping system is that the 64 electrodes of the Constellation basket catheter are arranged in a uniform 8x8 grid in a fixed position within the 2D representation of the LA. These spatial assumptions may lead to errors in phase animation as the actual 3D locations of the basket catheter are not taken into consideration. In Chapter 3, we therefore determined whether rotational activity detected in 2D phase maps were observed in corresponding 3D phase maps. We found that none of the rotors observed in 2D phase maps were seen in the same time segments and anatomical locations in 3D phase maps. The 2D phase detected rotors either corresponded in 3D phase maps to wavefronts (single or multiple), disorganized activity or an absence of basket coverage at the corresponding 3D anatomical site. With the increasing clinical use of the Constellation basket catheter in currently available mapping systems, Chapter 4 evaluated the efficacy of this catheter. We found that there were significant limitations of the basket catheter in terms of electrode contact and coverage of the LA. In addition, there was regional variation of coverage with preferential coverage of the lateral wall and absence of contact with the septum. These findings suggest that there is a need for the development of high density basket catheters which provide uniform LA coverage. Prior to the current focus on AF, atrial macro-reentry was the subject of extensive research. The recent development of high-density high-resolution 3D mapping provides an opportunity to study atrial macro-reentry to a level of detail not…

Subjects/Keywords: atrial fibrillation; atrial flutter; phase mapping

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pathik, M. B. (2017). New insights into the mechanisms of atrial arrhythmias using novel three dimensional mapping techniques. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/194696

Chicago Manual of Style (16^th Edition):

Pathik, Manaswi Bhupesh. “New insights into the mechanisms of atrial arrhythmias using novel three dimensional mapping techniques.” 2017. Doctoral Dissertation, University of Melbourne. Accessed July 22, 2019. http://hdl.handle.net/11343/194696.

MLA Handbook (7^th Edition):

Pathik, Manaswi Bhupesh. “New insights into the mechanisms of atrial arrhythmias using novel three dimensional mapping techniques.” 2017. Web. 22 Jul 2019.

Vancouver:

Pathik MB. New insights into the mechanisms of atrial arrhythmias using novel three dimensional mapping techniques. [Internet] [Doctoral dissertation]. University of Melbourne; 2017. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/11343/194696.

Council of Science Editors:

Pathik MB. New insights into the mechanisms of atrial arrhythmias using novel three dimensional mapping techniques. [Doctoral Dissertation]. University of Melbourne; 2017. Available from: http://hdl.handle.net/11343/194696

University of Vermont

4. Benson, Bryce Eric. Mapping the Substrate of Atrial Fibrillation: Tools and Techniques.

Degree: PhD, Bioengineering, 2016, University of Vermont

URL: https://scholarworks.uvm.edu/graddis/634

► Atrial fibrillation (AF) is the most common cardiac arrhythmia that affects an estimated 33.5 million people worldwide. Despite its prevalence and economic burden, treatments… (more)

Subjects/Keywords: Atrial Fibrillation; computer modeling; electrophysiology

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APA (6^th Edition):

Benson, B. E. (2016). Mapping the Substrate of Atrial Fibrillation: Tools and Techniques. (Doctoral Dissertation). University of Vermont. Retrieved from https://scholarworks.uvm.edu/graddis/634

Chicago Manual of Style (16^th Edition):

Benson, Bryce Eric. “Mapping the Substrate of Atrial Fibrillation: Tools and Techniques.” 2016. Doctoral Dissertation, University of Vermont. Accessed July 22, 2019. https://scholarworks.uvm.edu/graddis/634.

MLA Handbook (7^th Edition):

Benson, Bryce Eric. “Mapping the Substrate of Atrial Fibrillation: Tools and Techniques.” 2016. Web. 22 Jul 2019.

Vancouver:

Benson BE. Mapping the Substrate of Atrial Fibrillation: Tools and Techniques. [Internet] [Doctoral dissertation]. University of Vermont; 2016. [cited 2019 Jul 22]. Available from: https://scholarworks.uvm.edu/graddis/634.

Council of Science Editors:

Benson BE. Mapping the Substrate of Atrial Fibrillation: Tools and Techniques. [Doctoral Dissertation]. University of Vermont; 2016. Available from: https://scholarworks.uvm.edu/graddis/634

University of Aberdeen

5. Gibson, Patrick H. The prediction of atrial fibrillation following coronary artery bypass grafting.

Degree: 2010, University of Aberdeen

URL: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165981 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540432

► Atrial fibrillation (AF) is one of the most frequent complications following coronary artery bypass grafting (CABG), occurring in up to 40% of patients. This thesis… (more)

▼ Atrial fibrillation (AF) is one of the most frequent complications following coronary artery bypass grafting (CABG), occurring in up to 40% of patients. This thesis investigates the utility of non-invasive markers of left ventricular filling pressure in predicting AF in this setting, and assesses a novel marker of inflammation in the same role. Given the haemodynamic changes occurring peri-operatively it was hypothesised that acute changes in left ventricular filling pressure (LVFP), and resulting atrial stretch, might predispose to post-operative AF. Levels of the natriuretic peptides, BNP and NT-proBNP, were measured pre-operatively in 275 patients undergoing non-emergency CABG, and detailed echocardiographic examination performed. The natriuretic peptides were higher in patients who developed AF, and both were independently predictive of post-operative AF in multivariable analysis. However, their clinical utility appears modest in this role. The only significant echocardiographic predictors of AF were the transmitral E to A-wave ratio and the early mitral annulus velocity. None of the echocardiographic parameters remained independently predictive in multivariable analysis. The strongest echocardiographic correlate of both BNP and NT-proBNP was the left atrial volume index (LAVi), a marker of chronic LV filling pressure. Patients undergoing CABG are subject to a significant peri-operative inflammatory response. This was investigated in the same cohort by means of the neutrophil/lymphocyte (N/L) ratio. Patients who developed AF had greater pre- and post-operative N/L ratios, with no preoperative differences observed in other white blood cell parameters or C-reactive protein. In multivariate models, a greater post-operative N/L ratio was independently associated with the incidence of AF. In patients undergoing CABG, AF remains difficult to predict from pre-operative variables, although age appears to be a consistent factor. Difficulties in the prediction of AF in this setting are likely to reflect the heterogeneity of influences on the development of the arrhythmia in this setting.

Subjects/Keywords: 617; Atrial fibrillation : Coronary disease

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APA (6^th Edition):

Gibson, P. H. (2010). The prediction of atrial fibrillation following coronary artery bypass grafting. (Doctoral Dissertation). University of Aberdeen. Retrieved from http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165981 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540432

Chicago Manual of Style (16^th Edition):

Gibson, Patrick H. “The prediction of atrial fibrillation following coronary artery bypass grafting.” 2010. Doctoral Dissertation, University of Aberdeen. Accessed July 22, 2019. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165981 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540432.

MLA Handbook (7^th Edition):

Gibson, Patrick H. “The prediction of atrial fibrillation following coronary artery bypass grafting.” 2010. Web. 22 Jul 2019.

Vancouver:

Gibson PH. The prediction of atrial fibrillation following coronary artery bypass grafting. [Internet] [Doctoral dissertation]. University of Aberdeen; 2010. [cited 2019 Jul 22]. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165981 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540432.

Council of Science Editors:

Gibson PH. The prediction of atrial fibrillation following coronary artery bypass grafting. [Doctoral Dissertation]. University of Aberdeen; 2010. Available from: http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=165981 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540432

University of Hong Kong

6. 龍梅菁; Long, Meijing. Association of electrocardiographic PR interval and obesity with atrial fibrillation in older Chinese : the Guangzhou biobank cohort study.

Degree: PhD, 2016, University of Hong Kong

URL: http://hdl.handle.net/10722/239384

► Background: Obesity is related to altered atrioventricular conduction and an independent risk factor for AF. There has been no study on the longitudinal association of… (more)

▼ Background: Obesity is related to altered atrioventricular conduction and an independent risk factor for AF. There has been no study on the longitudinal association of obesity with PR prolongation in community population. Few studies documented associations of longer and shorter PR interval with AF risk, and no study on Asian populations. Objectives 1. To examine the associations of body mass index (BMI) with PR interval/first-degree atrioventricular block (AVB1); examine the associations of BMI/obesity (BMI ≥25 mg/m2) with atrial fibrillation (AF) risk cross-sectionally and longitudinally; 2. To examine the association of PR interval with AF risk; and analyze whether longer PR interval acts as a mediator of the association between obesity and AF risk. Methods: 30518 Chinese aged 50+ years (27% men) from the Guangzhou Biobank Cohort Study. 17129 participants (27% men) were repeated 12-lead electrocardiograms after a 4-year median follow-up. Electrocardiographic delta waves were excluded from the thesis. Results: BMI was positively associated with PR interval in both sexes (P <0.001), and the association was stronger in men than in women from baseline data (P for interaction <0.001). A 12% increase in the risk of AVB1 at follow-up per kg/m2 increase in baseline BMI was observed; baseline obesity increased risk of AVB1 at follow-up adjusting for potential confounders in men (RR=2.34, 95% confidence interval (CI):1.55-3.53). No significant longitudinal association was found in women, which could be due to an insufficient follow-up period. Current smoking was associated with shorter PR interval in baseline data (β-coefficients=-1.56, P <0.001). However, current smoking strengthened the positive association between BMI and PR interval in both normal and obese individuals (P for interaction=0.01). Higher BMI was associated increased AF risk in baseline data (OR=1.07 per kg/m2, P <0.05). Baseline obesity increased risk of AF at follow-up adjusting for potential confounders (RR=2.43, P<0.05). Baseline underweight increased the risk for AF at follow-up (RR=3.04, 95% CI: 1.04-8.87), although this needs to be confirmed and checked whether this association was population-specific. A J-shaped relation between PR interval and AF risk at follow-up after controlling for potential confounders was found. Both longer PR interval [≥160 ms] (RR=2.00, 95% CI: 1.07-3.75) and short PR interval [<140 ms] (RR=1.66, 95% CI: 0.83-3.32) had an adverse effect on the development of AF compared with healthy controls [PR interval within 140-159 ms], but shorter PR did not reach statistical significance. Longer PR interval [≥160 ms] was a significant partial mediator (P=0.04); a minor effect of baseline higher BMI (8%) on the development of AF via longer PR interval was observed, and the majority of obesity effect acted on AF directly. Conclusions: Data from southern Chinese showed obesity was associated with longer PR interval; and longer PR interval was an independent risk factor for new onset AF after controlling for…

Subjects/Keywords: Atrial fibrillation; Electrocardiography; Obesity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

龍梅菁; Long, M. (2016). Association of electrocardiographic PR interval and obesity with atrial fibrillation in older Chinese : the Guangzhou biobank cohort study. (Doctoral Dissertation). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/239384

Chicago Manual of Style (16^th Edition):

龍梅菁; Long, Meijing. “Association of electrocardiographic PR interval and obesity with atrial fibrillation in older Chinese : the Guangzhou biobank cohort study.” 2016. Doctoral Dissertation, University of Hong Kong. Accessed July 22, 2019. http://hdl.handle.net/10722/239384.

MLA Handbook (7^th Edition):

龍梅菁; Long, Meijing. “Association of electrocardiographic PR interval and obesity with atrial fibrillation in older Chinese : the Guangzhou biobank cohort study.” 2016. Web. 22 Jul 2019.

Vancouver:

龍梅菁; Long M. Association of electrocardiographic PR interval and obesity with atrial fibrillation in older Chinese : the Guangzhou biobank cohort study. [Internet] [Doctoral dissertation]. University of Hong Kong; 2016. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/10722/239384.

Council of Science Editors:

龍梅菁; Long M. Association of electrocardiographic PR interval and obesity with atrial fibrillation in older Chinese : the Guangzhou biobank cohort study. [Doctoral Dissertation]. University of Hong Kong; 2016. Available from: http://hdl.handle.net/10722/239384

University of Hong Kong

7. Au-doung, Lung-wai. Cost and resource utilisation in patients with atrial fibrillation with/without ischemic stroke.

Degree: Master of Medical Sciences, 2015, University of Hong Kong

URL: Au-doung, L. [歐陽隆偉]. (2015). Cost and resource utilisation in patients with atrial fibrillation with/without ischemic stroke. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5611970 ; http://hdl.handle.net/10722/221499

► Atrial fibrillation (AF) is a risk factor of ischaemic stroke and mainly affects elderly population. In the aging era, AF is a worldwide prevalent disease… (more)

▼ Atrial fibrillation (AF) is a risk factor of ischaemic stroke and mainly affects elderly population. In the aging era, AF is a worldwide prevalent disease that increasingly number of people being suffered and developed ischaemic stroke later. The cost of managing ischaemic stroke can be reduced if patients with AF can receive better treatment to prevent ischaemic stroke. The cost of ischaemic stroke in patients with AF is explored in existing published literature, but the volume is limited and variations exist among costing components assessed. Besides, no systematic review has been conducted before, so it is very difficult to quantify the overall cost of ischaemic stroke. The aim of this study is to investigate and summarize the cost and resource utilisation of patients with AF with ischaemic stroke and highlight the importance of ischaemic stroke prevention. A systematic review was conducted in four databases, including PUBMED, EMBASE, Web of Science and the health economic evaluation database (HEED)to review the existing literatures on the cost in patients with AF with ischaemic stroke. Costs reported in the included studies were converted into international dollars in 2015 values. One thousand five hundred and thirty-five studies were searched systematically and 16 studies were included following Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA).Result showed that the total direct medical cost in treating patients with ischaemic stroke ranged from1,605 to 86,883 per patient in different countries. Hospitalization costs contributed greatest to total medical costs, accounting for nearly half of the total. In addition, the management of ischaemic stroke in patients with AF is costly. The total direct medical cost was 2 -2.8 folds higher than patients with AF without ischaemic stroke. Furthermore, correlation analyses were conducted to investigate the relationship between GDP per capita, mean age of patients, total direct medical costs and length of stay (LOS)(as an indicator of resource utilisation).The results showed that patients had a higher total direct medical cost if they lived in a country with a higher GDP per capita value in both original reported year (r²= 0.381, p= 0.014)and converted year of 2015(r2= 0.279, p= 0.043). However, a weak positive relationship was observed in the mean age of patients and total direct medical costs in both original reported year (r²= 0.119, p= 0.187) and converted year (r²= 0.125, p= 0.265). The mean length of stay (LOS) among patients with AF with ischaemic stroke ranged from 5.2 to 20 days. Elderly patients tended to stay longer in hospital, but this observation was not statistically significant (r²= 0.393, p= 0.132). This review provides an updated and comprehensive summary of ischaemic stroke related cost in patients with AF globally. As the management of ischaemic stroke is costly in patients with AF, there is a need to minimize the risk of ischaemic stroke in patients with AF in order to avoid a higher medical cost to patients and…

Subjects/Keywords: Cerebrovascular disease; Atrial fibrillation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Au-doung, L. (2015). Cost and resource utilisation in patients with atrial fibrillation with/without ischemic stroke. (Masters Thesis). University of Hong Kong. Retrieved from Au-doung, L. [歐陽隆偉]. (2015). Cost and resource utilisation in patients with atrial fibrillation with/without ischemic stroke. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5611970 ; http://hdl.handle.net/10722/221499

Chicago Manual of Style (16^th Edition):

Au-doung, Lung-wai. “Cost and resource utilisation in patients with atrial fibrillation with/without ischemic stroke.” 2015. Masters Thesis, University of Hong Kong. Accessed July 22, 2019. Au-doung, L. [歐陽隆偉]. (2015). Cost and resource utilisation in patients with atrial fibrillation with/without ischemic stroke. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5611970 ; http://hdl.handle.net/10722/221499.

MLA Handbook (7^th Edition):

Au-doung, Lung-wai. “Cost and resource utilisation in patients with atrial fibrillation with/without ischemic stroke.” 2015. Web. 22 Jul 2019.

Vancouver:

Au-doung L. Cost and resource utilisation in patients with atrial fibrillation with/without ischemic stroke. [Internet] [Masters thesis]. University of Hong Kong; 2015. [cited 2019 Jul 22]. Available from: Au-doung, L. [歐陽隆偉]. (2015). Cost and resource utilisation in patients with atrial fibrillation with/without ischemic stroke. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5611970 ; http://hdl.handle.net/10722/221499.

Council of Science Editors:

Au-doung L. Cost and resource utilisation in patients with atrial fibrillation with/without ischemic stroke. [Masters Thesis]. University of Hong Kong; 2015. Available from: Au-doung, L. [歐陽隆偉]. (2015). Cost and resource utilisation in patients with atrial fibrillation with/without ischemic stroke. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5611970 ; http://hdl.handle.net/10722/221499

University of Hong Kong

8. 龍梅菁; Long, Meijing. Prevalence and risk factor of atrial fibrillation in older Chinese: the Guangzhou biobank cohort study (GBCS).

Degree: MPH, 2008, University of Hong Kong

URL: Long, M. [龍梅菁]. (2008). Prevalence and risk factor of atrial fibrillation in older Chinese : the Guangzhou biobank cohort study (GBCS). (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4171129 ; http://dx.doi.org/10.5353/th_b4171129 ; http://hdl.handle.net/10722/55181

published_or_final_version

Community Medicine

Master

Master of Public Health

Subjects/Keywords: Atrial fibrillation.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

龍梅菁; Long, M. (2008). Prevalence and risk factor of atrial fibrillation in older Chinese: the Guangzhou biobank cohort study (GBCS). (Masters Thesis). University of Hong Kong. Retrieved from Long, M. [龍梅菁]. (2008). Prevalence and risk factor of atrial fibrillation in older Chinese : the Guangzhou biobank cohort study (GBCS). (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4171129 ; http://dx.doi.org/10.5353/th_b4171129 ; http://hdl.handle.net/10722/55181

Chicago Manual of Style (16^th Edition):

龍梅菁; Long, Meijing. “Prevalence and risk factor of atrial fibrillation in older Chinese: the Guangzhou biobank cohort study (GBCS).” 2008. Masters Thesis, University of Hong Kong. Accessed July 22, 2019. Long, M. [龍梅菁]. (2008). Prevalence and risk factor of atrial fibrillation in older Chinese : the Guangzhou biobank cohort study (GBCS). (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4171129 ; http://dx.doi.org/10.5353/th_b4171129 ; http://hdl.handle.net/10722/55181.

MLA Handbook (7^th Edition):

龍梅菁; Long, Meijing. “Prevalence and risk factor of atrial fibrillation in older Chinese: the Guangzhou biobank cohort study (GBCS).” 2008. Web. 22 Jul 2019.

Vancouver:

龍梅菁; Long M. Prevalence and risk factor of atrial fibrillation in older Chinese: the Guangzhou biobank cohort study (GBCS). [Internet] [Masters thesis]. University of Hong Kong; 2008. [cited 2019 Jul 22]. Available from: Long, M. [龍梅菁]. (2008). Prevalence and risk factor of atrial fibrillation in older Chinese : the Guangzhou biobank cohort study (GBCS). (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4171129 ; http://dx.doi.org/10.5353/th_b4171129 ; http://hdl.handle.net/10722/55181.

Council of Science Editors:

龍梅菁; Long M. Prevalence and risk factor of atrial fibrillation in older Chinese: the Guangzhou biobank cohort study (GBCS). [Masters Thesis]. University of Hong Kong; 2008. Available from: Long, M. [龍梅菁]. (2008). Prevalence and risk factor of atrial fibrillation in older Chinese : the Guangzhou biobank cohort study (GBCS). (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4171129 ; http://dx.doi.org/10.5353/th_b4171129 ; http://hdl.handle.net/10722/55181

University of Hong Kong

9. 蕭頌華; Siu, Chung-wah, David. Current perspective of new-onset atrial fibrillation.

Degree: Doctor of Medicine, 2010, University of Hong Kong

URL: Siu, C. D. [蕭頌華]. (2010). Current perspective of new-onset atrial fibrillation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4520532 ; http://dx.doi.org/10.5353/th_b4520532 ; http://hdl.handle.net/10722/132148

published_or_final_version

Medicine

Master

Doctor of Medicine

Subjects/Keywords: Atrial fibrillation.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

蕭頌華; Siu, Chung-wah, D. (2010). Current perspective of new-onset atrial fibrillation. (Doctoral Dissertation). University of Hong Kong. Retrieved from Siu, C. D. [蕭頌華]. (2010). Current perspective of new-onset atrial fibrillation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4520532 ; http://dx.doi.org/10.5353/th_b4520532 ; http://hdl.handle.net/10722/132148

Chicago Manual of Style (16^th Edition):

蕭頌華; Siu, Chung-wah, David. “Current perspective of new-onset atrial fibrillation.” 2010. Doctoral Dissertation, University of Hong Kong. Accessed July 22, 2019. Siu, C. D. [蕭頌華]. (2010). Current perspective of new-onset atrial fibrillation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4520532 ; http://dx.doi.org/10.5353/th_b4520532 ; http://hdl.handle.net/10722/132148.

MLA Handbook (7^th Edition):

蕭頌華; Siu, Chung-wah, David. “Current perspective of new-onset atrial fibrillation.” 2010. Web. 22 Jul 2019.

Vancouver:

蕭頌華; Siu, Chung-wah D. Current perspective of new-onset atrial fibrillation. [Internet] [Doctoral dissertation]. University of Hong Kong; 2010. [cited 2019 Jul 22]. Available from: Siu, C. D. [蕭頌華]. (2010). Current perspective of new-onset atrial fibrillation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4520532 ; http://dx.doi.org/10.5353/th_b4520532 ; http://hdl.handle.net/10722/132148.

Council of Science Editors:

蕭頌華; Siu, Chung-wah D. Current perspective of new-onset atrial fibrillation. [Doctoral Dissertation]. University of Hong Kong; 2010. Available from: Siu, C. D. [蕭頌華]. (2010). Current perspective of new-onset atrial fibrillation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b4520532 ; http://dx.doi.org/10.5353/th_b4520532 ; http://hdl.handle.net/10722/132148

University of Tasmania

10. Bista, D. Antithrombotic therapy in patients with atrial fibrillation : the Tasmanian experience.

Degree: 2016, University of Tasmania

URL: https://eprints.utas.edu.au/23415/1/Bista_whole_thesis.pdf

► Atrial fibrillation (AF) is the most common sustained cardiac rhythm disorder and is increasing in incidence and prevalence in ageing populations. It is estimated that… (more)

▼ Atrial fibrillation (AF) is the most common sustained cardiac rhythm disorder and is increasing in incidence and prevalence in ageing populations. It is estimated that 1.5-2% of the developed world suffers from AF. The risk of stroke and thromboembolism (TE) is increased 4-5 fold by non-valvular atrial fibrillation (NVAF) and nearly 15% of all strokes are caused by AF. Judicious use of antithrombotic therapy significantly reduces the risk of stroke for most patients who have AF. Conversely, underuse of antithrombotic therapy is associated with an increase in the rates of death and ischaemic events (stroke, transient ischaemic attack [TIA], or myocardial infarction [MI]). Despite the proven benefits of anticoagulant therapy among high-risk patients with AF, there have been frequent reports of discordance between guideline recommendations and anticoagulant prescribing patterns leading to problem of underutilisation in patients with AF in real-world practices. During the time period of this study there were limited data available on the characteristics, clinical management and outcomes of patients with AF from an Australian perspective. The available literature suggested that there was underutilisation of anticoagulant therapy, although this data came from relatively small observational trials in selected patient groups. The Commonwealth Review of Anticoagulation Therapies in AF in Australia identified that stroke prevention in individuals with AF required improvement, and highlighted a range of issues to be addressed related to the assessment of patients for stroke and bleeding risk, appropriate choice of antithrombotic agent(s) in patients with multiple comorbidities, and the monitoring of patients. The review stressed the need for local data on which to base recommendations regarding the treatment of AF. Meanwhile, little was known about the clinical outcomes and safety of direct oral anticoagulants (DOACs) outside the trial setting. In 2011, dabigatran’s sponsor launched a patient familiarisation program in which over 28,000 Australians were enrolled. Thus, we established that there was a critical need for local data regarding the safety of antithrombotic medications, including the DOACs, in the treatment of AF. We designed this study, the Tasmanian AF (TAF) Study, as a starting point to providing comprehensive data describing the outcomes of stroke prevention strategies in Tasmanian patients with AF. The TAF study is an ongoing retrospective study that enrols patients from 3 different hospitals in Tasmania, Australia; the Royal Hobart Hospital (RHH), Launceston General Hospital (LGH) and North West Regional Hospital (NWRH). The rationale behind this project was to derive local data on usage pattern of antithrombotic therapy, clinical outcomes and their safety profile in Australian sub-population - initially prior to the Pharmaceutical Benefits Scheme (PBS) listing of DOACs, and then to use the established database to monitor the impact of the introduction of the DOACs into clinical practice. Our main objectives…

Subjects/Keywords: atrial fibrillation; anticoagulants; bleeding; thromboembolism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bista, D. (2016). Antithrombotic therapy in patients with atrial fibrillation : the Tasmanian experience. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/23415/1/Bista_whole_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Bista, D. “Antithrombotic therapy in patients with atrial fibrillation : the Tasmanian experience.” 2016. Thesis, University of Tasmania. Accessed July 22, 2019. https://eprints.utas.edu.au/23415/1/Bista_whole_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Bista, D. “Antithrombotic therapy in patients with atrial fibrillation : the Tasmanian experience.” 2016. Web. 22 Jul 2019.

Vancouver:

Bista D. Antithrombotic therapy in patients with atrial fibrillation : the Tasmanian experience. [Internet] [Thesis]. University of Tasmania; 2016. [cited 2019 Jul 22]. Available from: https://eprints.utas.edu.au/23415/1/Bista_whole_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Bista D. Antithrombotic therapy in patients with atrial fibrillation : the Tasmanian experience. [Thesis]. University of Tasmania; 2016. Available from: https://eprints.utas.edu.au/23415/1/Bista_whole_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

11. Law, Phillip Robert. Tissue engineering of the human atrium : approaching mechanisms of genesis and control of atrial fibrillation.

Degree: PhD, 2011, University of Manchester

URL: https://www.research.manchester.ac.uk/portal/en/theses/tissue-engineering-of-the-human-atrium – approaching-mechanisms-of-genesis-and-control-of-atrial-fibrillation(18cd949c-6a4d-4c91-8551-a17bb56991ce).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529215

► Cardiovascular disease is prevalent across the western world and is a major cause of morbidity and mortality, accounting for approximately a third of all fatalities.… (more)

▼ Cardiovascular disease is prevalent across the western world and is a major cause of morbidity and mortality, accounting for approximately a third of all fatalities. Investigating the heart by simulating its electrophysiology via the aid of mathematical models has advanced significantly over the past 60 years and is now a well established field. While much of the research focus is placed on the ventricles, the study of the atria is in comparison neglected. Therefore this Thesis is focused on the genesis and maintenance of atrial fibrillation (AF). A series of case studies are performed whereby established biophysically detailed mathematical models are implemented and modified to incorporate electrophysical alterations of atrial cells resulting from a variety of external conditions. The opening section of this Thesis is dedicated to developing a background to the field, including a discussion into the clinical aspect of the diagnosis and management of AF. The suitability of two atrial cell models is discussed and the development of single cell, 1D, 2D, and 3D multi-scale simulation protocols are described in detail. In addition measurements taken to quantify the arrhythmogenic properties of the cells susceptibility to AF are outlined. The second section is focused on the incorporation of conditions thought to enhance atrial tissues ability to initiate and maintain the genesis of AF. Included is a case study into the missence S140G gene mutation, and elevated physiological levels of the hormone Homocystein. The third section investigates the effectiveness of well established and widely used pharmacological treatments such as Beta-Blockers. In addition possible avenues of investigations for the development of atrial specific drugs are explored. These include blocking of the ultra rapid potassium channel and a more novel target for therapy via the targeting of 5HT4 receptors; which is transcribed solely in the atria and alters the electrophysical properties of the L-type Calcium current. The final part of this Thesis is dedicated to the development of a 2D atrial sheet model which includes electrical and spatial heterogeneities via the inclusion of multiple cell types and basic fiber orientation respectively. This allows for an investigation into the role that heterogeneities play in role genesis and maintenance of AF. The main finding of this Thesis is that alterations to the electrophysiology of atrial cells, due to external factors, can be successfully simulated via the implementation of mathematically detailed atrial cell models. It is concluded that simulations of the KENQ1 mutation and elevated levels of Homocystein successfully reproduce conditions which increase the onset of AF. Established treatments such as Beta-Blockers are found to have limited effectiveness. Possible theoretical treatments, such as the blocking of IKur, are found to provide a small amount of therapeutic benefit. In contrast, investigations into the effects of Serotonin were inconclusive. The study into the 2D atria indicated the importance…

Subjects/Keywords: 612.1; Atrial Fibrillation; Cardiac Modeling

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Law, P. R. (2011). Tissue engineering of the human atrium : approaching mechanisms of genesis and control of atrial fibrillation. (Doctoral Dissertation). University of Manchester. Retrieved from https://www.research.manchester.ac.uk/portal/en/theses/tissue-engineering-of-the-human-atrium – approaching-mechanisms-of-genesis-and-control-of-atrial-fibrillation(18cd949c-6a4d-4c91-8551-a17bb56991ce).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529215

Chicago Manual of Style (16^th Edition):

Law, Phillip Robert. “Tissue engineering of the human atrium : approaching mechanisms of genesis and control of atrial fibrillation.” 2011. Doctoral Dissertation, University of Manchester. Accessed July 22, 2019. https://www.research.manchester.ac.uk/portal/en/theses/tissue-engineering-of-the-human-atrium – approaching-mechanisms-of-genesis-and-control-of-atrial-fibrillation(18cd949c-6a4d-4c91-8551-a17bb56991ce).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529215.

MLA Handbook (7^th Edition):

Law, Phillip Robert. “Tissue engineering of the human atrium : approaching mechanisms of genesis and control of atrial fibrillation.” 2011. Web. 22 Jul 2019.

Vancouver:

Law PR. Tissue engineering of the human atrium : approaching mechanisms of genesis and control of atrial fibrillation. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2019 Jul 22]. Available from: https://www.research.manchester.ac.uk/portal/en/theses/tissue-engineering-of-the-human-atrium – approaching-mechanisms-of-genesis-and-control-of-atrial-fibrillation(18cd949c-6a4d-4c91-8551-a17bb56991ce).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529215.

Council of Science Editors:

Law PR. Tissue engineering of the human atrium : approaching mechanisms of genesis and control of atrial fibrillation. [Doctoral Dissertation]. University of Manchester; 2011. Available from: https://www.research.manchester.ac.uk/portal/en/theses/tissue-engineering-of-the-human-atrium – approaching-mechanisms-of-genesis-and-control-of-atrial-fibrillation(18cd949c-6a4d-4c91-8551-a17bb56991ce).html ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529215

University of Debrecen

12. Khojasteh-Del, Milad. Up-to-date management of atrial fibrillation .

Degree: DE – Általános Orvostudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/195524

► This essay tires to simplify the disease process of atrial fibrillation, classify current subtypes and introduce the most commonly used diagnostic approaches. Furthurmore I discuss… (more)

Subjects/Keywords: Atrial; fibrillation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Khojasteh-Del, M. (n.d.). Up-to-date management of atrial fibrillation . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/195524

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Khojasteh-Del, Milad. “Up-to-date management of atrial fibrillation .” Thesis, University of Debrecen. Accessed July 22, 2019. http://hdl.handle.net/2437/195524.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Khojasteh-Del, Milad. “Up-to-date management of atrial fibrillation .” Web. 22 Jul 2019.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Khojasteh-Del M. Up-to-date management of atrial fibrillation . [Internet] [Thesis]. University of Debrecen; [cited 2019 Jul 22]. Available from: http://hdl.handle.net/2437/195524.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Khojasteh-Del M. Up-to-date management of atrial fibrillation . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/195524

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

National University of Ireland – Galway

13. McGrath, Emer. Atrial fibrillation and stroke: natural history, risk factors and clinical consequences.

Degree: 2015, National University of Ireland – Galway

URL: http://hdl.handle.net/10379/5032

► Stroke is a leading cause of adult disability and the third leading cause of mortality in developed countries. Atrial fibrillation is a major risk factor… (more)

▼ Stroke is a leading cause of adult disability and the third leading cause of mortality in developed countries. Atrial fibrillation is a major risk factor for ischaemic stroke, associated with a five-fold increase in risk. When patients with atrial fibrillation suffer an ischaemic stroke, they have a two-fold increased risk of subsequent disability and death, compared to patients without atrial fibrillation. Oral anticoagulants (e.g. warfarin) reduce the risk of ischaemic stroke in patients with atrial fibrillation by two-thirds. However, they also increase bleeding risk, most importantly intracerebral haemorrhage. Employing a number of approaches to statistical analyses, this thesis addresses the following areas: 1) the comparative importance of risk factors for ischaemic stroke and intracerebral haemorrhage in patients with stroke and atrial fibrillation, with a particular emphasis on risk factors common to both stroke types, 2) the natural history of acute ischaemic stroke in patients with atrial fibrillation and the clinical factors which explain the association between atrial fibrillation and increased mortality and disability following acute ischaemic stroke, and 3) the association between different antithrombotic regimens on discharge and risk of major vascular events and bleeding in patients with atrial fibrillation following acute ischaemic stroke, with a particular focus on patients with severe stroke and those with coronary artery disease. This thesis also evaluates the association between participation in Heartwatch, a risk factor modification program for the secondary prevention of cardiovascular disease, and subsequent risk of stroke and other major vascular events in patients with prior stroke or coronary artery disease. This content provides novel information which furthers our understanding of the association between atrial fibrillation and poor stroke outcomes, helps to optimise selection of antithrombotic therapy in patients with atrial fibrillation, and investigates the potential of Heartwatch as a primary-care based programme for the secondary prevention of stroke and cardiovascular disease. Advisors/Committee Members: O'Donnell, Martin, Health Research Board.

Subjects/Keywords: Stroke; Atrial fibrillation; Medicine

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McGrath, E. (2015). Atrial fibrillation and stroke: natural history, risk factors and clinical consequences. (Thesis). National University of Ireland – Galway. Retrieved from http://hdl.handle.net/10379/5032

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McGrath, Emer. “Atrial fibrillation and stroke: natural history, risk factors and clinical consequences.” 2015. Thesis, National University of Ireland – Galway. Accessed July 22, 2019. http://hdl.handle.net/10379/5032.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McGrath, Emer. “Atrial fibrillation and stroke: natural history, risk factors and clinical consequences.” 2015. Web. 22 Jul 2019.

Vancouver:

McGrath E. Atrial fibrillation and stroke: natural history, risk factors and clinical consequences. [Internet] [Thesis]. National University of Ireland – Galway; 2015. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/10379/5032.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McGrath E. Atrial fibrillation and stroke: natural history, risk factors and clinical consequences. [Thesis]. National University of Ireland – Galway; 2015. Available from: http://hdl.handle.net/10379/5032

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

National University of Ireland – Galway

14. McGrath, E. Atrial Fibrillation and Stroke: Natural History, Risk Factors and Clinical Consequences.

Degree: 2013, National University of Ireland – Galway

URL: http://hdl.handle.net/10379/3748

► Stroke is a leading cause of adult disability and the third leading cause of mortality in developed countries. Atrial fibrillation is a major risk factor… (more)

▼ Stroke is a leading cause of adult disability and the third leading cause of mortality in developed countries. Atrial fibrillation is a major risk factor for ischaemic stroke, associated with a five-fold increase in risk. When patients with atrial fibrillation suffer an ischaemic stroke, they have a two-fold increased risk of subsequent disability and death, compared to patients without atrial fibrillation. Oral anticoagulants (e.g. warfarin) reduce the risk of ischaemic stroke in patients with atrial fibrillation by two-thirds. However, they also increase bleeding risk, most importantly intracerebral haemorrhage. Employing a number of approaches to statistical analyses, this thesis addresses the following areas: 1) the comparative importance of risk factors for ischaemic stroke and intracerebral haemorrhage in patients with stroke and atrial fibrillation, with a particular emphasis on risk factors common to both stroke types, 2) the natural history of acute ischaemic stroke in patients with atrial fibrillation and the clinical factors which explain the association between atrial fibrillation and increased mortality and disability following acute ischaemic stroke, and 3) the association between different antithrombotic regimens on discharge and risk of major vascular events and bleeding in patients with atrial fibrillation following acute ischaemic stroke, with a particular focus on patients with severe stroke and those with coronary artery disease. This thesis also evaluates the association between participation in Heartwatch, a risk factor modification program for the secondary prevention of cardiovascular disease, and subsequent risk of stroke and other major vascular events in patients with prior stroke or coronary artery disease. This content provides novel information which furthers our understanding of the association between atrial fibrillation and poor stroke outcomes, helps to optimise selection of antithrombotic therapy in patients with atrial fibrillation, and investigates the potential of Heartwatch as a primary-care based programme for the secondary prevention of stroke and cardiovascular disease. Advisors/Committee Members: O'Donnell, Martin, Health Research Board.

Subjects/Keywords: Stroke; Atrial fibrillation; Medicine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McGrath, E. (2013). Atrial Fibrillation and Stroke: Natural History, Risk Factors and Clinical Consequences. (Thesis). National University of Ireland – Galway. Retrieved from http://hdl.handle.net/10379/3748

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

McGrath, E. “Atrial Fibrillation and Stroke: Natural History, Risk Factors and Clinical Consequences.” 2013. Thesis, National University of Ireland – Galway. Accessed July 22, 2019. http://hdl.handle.net/10379/3748.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

McGrath, E. “Atrial Fibrillation and Stroke: Natural History, Risk Factors and Clinical Consequences.” 2013. Web. 22 Jul 2019.

Vancouver:

McGrath E. Atrial Fibrillation and Stroke: Natural History, Risk Factors and Clinical Consequences. [Internet] [Thesis]. National University of Ireland – Galway; 2013. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/10379/3748.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

McGrath E. Atrial Fibrillation and Stroke: Natural History, Risk Factors and Clinical Consequences. [Thesis]. National University of Ireland – Galway; 2013. Available from: http://hdl.handle.net/10379/3748

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

15. Law, Phillip Robert. Tissue Engineering of the Human Atrium – Approaching Mechanisms of Genesis and Control of Atrial Fibrillation.

Degree: 2011, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:111902

► Cardiovascular disease is prevalent across the western world and is a major cause of morbidity and mortality, accounting for approximately a third of all fatalities.… (more)

▼ Cardiovascular disease is prevalent across the western world and is a major cause of morbidity and mortality, accounting for approximately a third of all fatalities. Investigating the heart by simulating its electrophysiology via the aid of mathematical models has advanced significantly over the past 60 years and is now a well established field. While much of the research focus is placed on the ventricles, the study of the atria is in comparison neglected. Therefore this Thesis is focused on the genesis and maintenance of atrial fibrillation (AF). A series of case studies are performed whereby established biophysically detailed mathematical models are implemented and modified to incorporate electrophysical alterations of atrial cells resulting from a variety of external conditions. The opening section of this Thesis is dedicated to developing a background to the field, including a discussion into the clinical aspect of the diagnosis and management of AF. The suitability of two atrial cell models is discussed and the development of single cell, 1D, 2D, and 3D multi-scale simulation protocols are described in detail. In addition measurements taken to quantify the arrhythmogenic properties of the cells susceptibility to AF are outlined. The second section is focused on the incorporation of conditions thought to enhance atrial tissues ability to initiate and maintain the genesis of AF. Included is a case study into the missence S140G gene mutation, and elevated physiological levels of the hormone Homocystein. The third section investigates the effectiveness of well established and widely used pharmacological treatments such as Beta-Blockers. In addition possible avenues of investigations for the development of atrial specific drugs are explored. These include blocking of the ultra rapid potassium channel and a more novel target for therapy via the targeting of 5HT4 receptors; which is transcribed solely in the atria and alters the electrophysical properties of the L-type Calcium current. The final part of this Thesis is dedicated to the development of a 2D atrial sheet model which includes electrical and spatial heterogeneities via the inclusion of multiple cell types and basic fiber orientation respectively. This allows for an investigation into the role that heterogeneities play in role genesis and maintenance of AF. The main finding of this Thesis is that alterations to the electrophysiology of atrial cells, due to external factors, can be successfully simulated via the implementation of mathematically detailed atrial cell models. It is concluded that simulations of the KENQ1 mutation and elevated levels of Homocystein successfully reproduce conditions which increase the onset of AF. Established treatments such as Beta-Blockers are found to have limited effectiveness. Possible theoretical treatments, such as the blocking of IKur, are found to provide a small amount of therapeutic benefit. In contrast, investigations into the effects of Serotonin were inconclusive. The study into the 2D atria indicated the importance… Advisors/Committee Members: Zhang, Henggui.

Subjects/Keywords: Atrial Fibrillation; Cardiac Modeling

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Law, P. R. (2011). Tissue Engineering of the Human Atrium – Approaching Mechanisms of Genesis and Control of Atrial Fibrillation. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:111902

Chicago Manual of Style (16^th Edition):

Law, Phillip Robert. “Tissue Engineering of the Human Atrium – Approaching Mechanisms of Genesis and Control of Atrial Fibrillation.” 2011. Doctoral Dissertation, University of Manchester. Accessed July 22, 2019. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:111902.

MLA Handbook (7^th Edition):

Law, Phillip Robert. “Tissue Engineering of the Human Atrium – Approaching Mechanisms of Genesis and Control of Atrial Fibrillation.” 2011. Web. 22 Jul 2019.

Vancouver:

Law PR. Tissue Engineering of the Human Atrium – Approaching Mechanisms of Genesis and Control of Atrial Fibrillation. [Internet] [Doctoral dissertation]. University of Manchester; 2011. [cited 2019 Jul 22]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:111902.

Council of Science Editors:

Law PR. Tissue Engineering of the Human Atrium – Approaching Mechanisms of Genesis and Control of Atrial Fibrillation. [Doctoral Dissertation]. University of Manchester; 2011. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:111902

University of Plymouth

16. Davies, Edward John. Current challenges in atrial fibrillation ablation.

Degree: Thesis (M.D.), 2016, University of Plymouth

URL: http://hdl.handle.net/10026.1/8067

► The ablative management of atrial fibrillation, despite a number of landmark discoveries, remains one of the most challenging fields in interventional electrophysiology. It is generally… (more)

Subjects/Keywords: 616.1; Atrial Fibrillation; Ablation; Cardiology

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APA (6^th Edition):

Davies, E. J. (2016). Current challenges in atrial fibrillation ablation. (Doctoral Dissertation). University of Plymouth. Retrieved from http://hdl.handle.net/10026.1/8067

Chicago Manual of Style (16^th Edition):

Davies, Edward John. “Current challenges in atrial fibrillation ablation.” 2016. Doctoral Dissertation, University of Plymouth. Accessed July 22, 2019. http://hdl.handle.net/10026.1/8067.

MLA Handbook (7^th Edition):

Davies, Edward John. “Current challenges in atrial fibrillation ablation.” 2016. Web. 22 Jul 2019.

Vancouver:

Davies EJ. Current challenges in atrial fibrillation ablation. [Internet] [Doctoral dissertation]. University of Plymouth; 2016. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/10026.1/8067.

Council of Science Editors:

Davies EJ. Current challenges in atrial fibrillation ablation. [Doctoral Dissertation]. University of Plymouth; 2016. Available from: http://hdl.handle.net/10026.1/8067

University of Adelaide

17. Varzaly, Jason Arya. The surgical management of atrial fibrillation.

Degree: 2018, University of Adelaide

URL: http://hdl.handle.net/2440/114066

► Atrial fibrillation (AF) is the most common atrial arrhythmia with an increasing prevalence identified worldwide. Symptomatic episodes have resulted in increasing hospitalisations such that this… (more)

▼ Atrial fibrillation (AF) is the most common atrial arrhythmia with an increasing prevalence identified worldwide. Symptomatic episodes have resulted in increasing hospitalisations such that this is now one of the dominant cardiovascular reasons for hospital admission in Australia. Beyond this, AF predisposes to heart failure, stroke and increasing cognitive decline. While medical therapy is available for the treatment of this condition the use of medication has not always proven sufficient for its management leading to the development of catheter and surgical ablation therapies. However, while surgical ablation procedures are widely utilised, the true efficacy of these approaches has not been well understood due to the wide variety of methodologies, concomitant procedures, technologies utilised and follow-up implemented. This thesis evaluates the current state of surgical ablation for AF. Chapter 1 provides an overview of the burden of AF on our community, the mechanisms of arrhythmia, a summary of medical and catheter based therapies and an in-depth analysis of how surgical therapies for atrial fibrillation were developed and the current approaches to surgical ablation with the current technologies available for use. Chapters 2 through 5 examine the efficacy and safety of the surgical ablation of AF when performed concurrent to mitral valve disease intervention, concomitant cardiac surgery in general, as a standalone procedure and as part of an emerging technique of hybrid ablation (joint surgical and cardiology electrophysiology) procedure. This evaluation has been performed through systematic literature review and meta-analyses identifying that surgical ablations procedures offer good medium term results in sinus rhythm maintenance (SRM) on and off antiarrhythmic drugs(AAD) achieving 79.6% SRM concurrent to mitral valve intervention, 79.6% on AAD and 65.3% off AAD concurrent to general cardiac surgical procedures, 85.3% on and 65.5% off AAD as a standalone procedure, and 79.4% on AAD and 70.7% off AAD when performed as a hybrid ablation procedure. The complication rates were low across all series, with the lowest complication rates associated with the hybrid procedure. Chapter 6 then presents the results of a series of experiments analysing the properties of surgical bipolar RF clamps and how ablation lesions are formed, with the identification that the efficacy of these surgical ablative tools is subject to the effects of contact force for the delivery of transmural lesions, increased numbers of ablation increase the likelihood of a transmural lesion irrespective of the device indicating transmurality, the presence of fat significantly attenuates the ability to deliver of a transmural lesion and these effects are amplified with increased thickness of the tissue being ablated. The observations of this thesis thus provide insight into the optimal conditions under which the surgical ablation of AF may obtain the best results in sinus rhythm maintenance. Advisors/Committee Members: Sanders, Prashanthan (advisor), Worthington, Michael (advisor), Lau, Dennis Hui Sung (advisor), Adelaide Medical School (school).

Subjects/Keywords: atrial fibrillation; surgery; cardiac

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Varzaly, J. A. (2018). The surgical management of atrial fibrillation. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/114066

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Varzaly, Jason Arya. “The surgical management of atrial fibrillation.” 2018. Thesis, University of Adelaide. Accessed July 22, 2019. http://hdl.handle.net/2440/114066.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Varzaly, Jason Arya. “The surgical management of atrial fibrillation.” 2018. Web. 22 Jul 2019.

Vancouver:

Varzaly JA. The surgical management of atrial fibrillation. [Internet] [Thesis]. University of Adelaide; 2018. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/2440/114066.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Varzaly JA. The surgical management of atrial fibrillation. [Thesis]. University of Adelaide; 2018. Available from: http://hdl.handle.net/2440/114066

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

18. Alasady, Muayad. Atrial arrhythmogenesis during myocardial infarction.

Degree: 2015, University of Adelaide

URL: http://hdl.handle.net/2440/93914

► Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in the clinical practice. However, the underlying mechanism or pathophysiology is not fully understood despite… (more)

▼ Atrial fibrillation (AF) is the most common cardiac arrhythmia encountered in the clinical practice. However, the underlying mechanism or pathophysiology is not fully understood despite our extensive research on AF. Furthermore, AF is commonly complicated by myocardial infarction (MI) with an incidence rate as high as 22%. Atrial fibrillation is also associated with poor short and long-term outcome after acute myocardial infarction. Although the association between myocardial infarction and AF is well established, our knowledge of the underlying mechanism by which MI leads to AF remains incomplete. This thesis focused on the pathophysiology of AF during MI in the clinical and bench-side setting. It also examined the prognostic value of AF post MI. Chapter 2 is a systematic review and meta-analysis showing us the trend in AF incidence and prognosis over the last three decades with our advancement in both intervention and pharmacological therapy. The study reveals a significant declining in AF incidence post MI; however, mortality remains higher compared to non-AF even during the interventional era (2000s). This may be attributed to the fact that AF patients are older with more comorbidities and had less invasive procedures compared to non-AF patients but clearly more work is required in this area. Chapter 3 focused on the mechanism of AF during the acute phase (60 minutes) of myocardial infarction. This was ovine model of myocardial infarction which was induced by percutaneous approach via the right femoral artery using angioplasty technique to induce infarct. The study involved 36 sheep divided into 3 groups; the first group included 12 animals with proximal left circumflex occlusion (LCX) to induce myocardial infarction with left atrial infarction or ischaemia. The second group included 12 animals with proximal occlusion of the left anterior descending artery (LAD) to induce myocardial infarction without left atrial ischaemia or infarction, and the third group included 12 sham animals which underwent the same procedure without induction of myocardial infarction. This model was unique as both LAD and LCX supply almost equivalent myocardium but the LCX only supplies the left atrium. The study found that occlusion of the LCX (MI with LA ischaemia) resulted in significant conduction slowing, greater inhomogeneity in conduction and more AF inducibility and duration compared to LAD group or controls. On the other hand, occlusion of LAD resulted in only moderate conduction slowing with a slight inhomogeneity in conduction compared to controls. The study concludes that atrial ischaemia is the dominant substrate for AF after MI. However, there is additional contribution to this substrate due to raised intra-atrial pressure with diastolic dysfunction which is associated with left ventricular infarction. Chapter 4 examined the role of atrial branches (left atrial ischaemia) disease on AF genesis during acute myocardial infarction in humans. This is a case-control study in which cases and controls were selected from a pool of… Advisors/Committee Members: Sanders, Prashanthan (advisor), Abhayaratna, Walter (advisor), Saint, David Albert (advisor), Brooks, Anthony Graham (advisor), Worthley, Matthew Ian (advisor), School of Medicine (school).

Subjects/Keywords: atrial fibrillation; myocardial infarction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alasady, M. (2015). Atrial arrhythmogenesis during myocardial infarction. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/93914

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alasady, Muayad. “Atrial arrhythmogenesis during myocardial infarction.” 2015. Thesis, University of Adelaide. Accessed July 22, 2019. http://hdl.handle.net/2440/93914.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alasady, Muayad. “Atrial arrhythmogenesis during myocardial infarction.” 2015. Web. 22 Jul 2019.

Vancouver:

Alasady M. Atrial arrhythmogenesis during myocardial infarction. [Internet] [Thesis]. University of Adelaide; 2015. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/2440/93914.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alasady M. Atrial arrhythmogenesis during myocardial infarction. [Thesis]. University of Adelaide; 2015. Available from: http://hdl.handle.net/2440/93914

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

19. Lim, Han Sung. Mechanisms of thrombogenesis in atrial fibrillation.

Degree: 2012, University of Adelaide

URL: http://hdl.handle.net/2440/95884

► Atrial fibrillation (AF) is the commonest sustained heart rhythm disorder in clinical practice. Non-valvular AF confers a 5-fold increased risk of stroke. Stroke in AF… (more)

▼ Atrial fibrillation (AF) is the commonest sustained heart rhythm disorder in clinical practice. Non-valvular AF confers a 5-fold increased risk of stroke. Stroke in AF is mainly due to thromboembolic phenomenon from the left atrium (LA). It is well known that atrial mechanical dysfunction contributes to thrombus formation. However, patients with AF are also known to exhibit a prothrombotic state and endothelial dysfunction, further contributing to this thromboembolic risk. There is debate as to whether the prothrombotic state and endothelial dysfunction seen in patients with AF are due to AF per se or the patients’ concurrent comorbidities. Chapter 2 examined the LA milieu in patients with lone non-valvular AF compared to patients with AF and comorbidities and controls. The study demonstrated increased platelet activation in the LA compared to the periphery in patients with lone AF. There was a step-wise increase in endothelial dysfunction in the lone AF cohort and AF with comorbidities compared to controls, indicating that both AF per se and its concurrent comorbidities contribute to endothelial dysfunction and thrombotic risk. Chapter 3 investigated the effect of rapid atrial rates in patients with AF compared to patients with supraventricular tachycardia. The study demonstrated rapid atrial rates increased LA platelet activation and thrombin generation in patients with AF. Left atrial thrombogenesis was markedly accentuated with atrio-ventricular dyssynchrony. In contrast, rapid atrial rates did not result in abnormal changes in patients with supraventricular tachycardia. These findings suggest rapid atrial rates, atrio-ventricular dyssynchrony and the abnormal substrate in patients with AF contribute to LA thrombogenesis in these patients. The relative contribution of the atrial rate or rhythm to LA thrombogenesis is unknown. Chapter 4 examined the effects of atrial rate and abnormal rhythm on LA thrombogenesis and demonstrated both rapid atrial rates and AF result in increased platelet activation and thrombin generation in the LA. However, AF also induced endothelial dysfunction and inflammation, not seen with rapid atrial rates alone. These findings suggest that while rapid atrial rates increase the thrombogenic risk, abnormal rhythm may further potentiate this risk. Catheter ablation therapy has emerged as an effective strategy for rhythm control in patients with AF. However, radiofrequency ablation is known to cause an increase in various markers of inflammation and patients are at risk of peri-procedural thromboembolic events. Chapter 5 examined inflammatory, myocardial injury and prothrombotic markers in AF patients undergoing catheter ablation during the peri-procedural period. The study demonstrated that patients exhibit an inflammatory response within the first few days post-ablation, and that this response predicted immediate AF recurrence. Prothrombotic markers were elevated one week post-ablation and may contribute to the increased peri-procedural thrombotic risk. Whether catheter ablation for AF… Advisors/Committee Members: Sanders, Prashanthan (advisor), Willoughby, Scott Richard (advisor), Worthley, Matthew Ian (advisor), School of Medical Sciences (school).

Subjects/Keywords: atrial fibrillation; stroke; thrombogenesis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lim, H. S. (2012). Mechanisms of thrombogenesis in atrial fibrillation. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/95884

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lim, Han Sung. “Mechanisms of thrombogenesis in atrial fibrillation.” 2012. Thesis, University of Adelaide. Accessed July 22, 2019. http://hdl.handle.net/2440/95884.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lim, Han Sung. “Mechanisms of thrombogenesis in atrial fibrillation.” 2012. Web. 22 Jul 2019.

Vancouver:

Lim HS. Mechanisms of thrombogenesis in atrial fibrillation. [Internet] [Thesis]. University of Adelaide; 2012. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/2440/95884.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lim HS. Mechanisms of thrombogenesis in atrial fibrillation. [Thesis]. University of Adelaide; 2012. Available from: http://hdl.handle.net/2440/95884

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Texas – Austin

20. Hulvershorn, Sarah Elizabeth. Outcomes and direct treatment costs with novel oral anticoagulants compared to clinic-monitored warfarin for stroke prevention in atrial fibrillation.

Degree: Pharmaceutical Sciences, 2014, University of Texas – Austin

URL: http://hdl.handle.net/2152/26481

► Objectives: To describe patient characteristics and evaluate costs and outcomes of novel oral anticoagulants compared to clinic-monitored warfarin for the prevention of stroke and systemic… (more)

▼ Objectives: To describe patient characteristics and evaluate costs and outcomes of novel oral anticoagulants compared to clinic-monitored warfarin for the prevention of stroke and systemic embolism in patients with atrial fibrillation within the Scott & White Healthcare system. Methods: Patients with atrial fibrillation, CHADS₂ score ≥ 1, and a prescription claim for dabigatran, rivaroxaban, or warfarin between 2010 and 2012 were evaluated over 12 months. Patients in the warfarin cohort were enrolled in an Anticoagulation Clinic. Patients were matched 1:1 for age, CHADS₂, and gender for comparisons between groups. Baseline characteristics, medication adherence, occurrence of adverse events, and treatment costs were compared using inferential statistics. Anticoagulation control was assessed for patients in the warfarin cohort. Results: 141 and 471 patients met criteria for the novel cohort group and the warfarin group, respectively. After matching, 136 remained in each cohort. Prior to matching, compared to the warfarin cohort, the novel anticoagulant cohort had a higher proportion of male patients (63% versus 49%), and lower average CHADS₂ score (2.65 versus 3.30), while average age in both cohorts was similar (75 years). Matched cohorts had similar adherence rates (88% for novel versus 87% for warfarin). After matching, annual medication cost in 2014 US dollars for dabigatran or rivaroxaban averaged 2,658 (SD 1,494) compared to 1,066 (SD 633) for warfarin, including monitoring costs. Annual total all-cause healthcare costs averaged 23,711 (SD 22,910) for dabigatran or rivaroxaban, compared to 18,248 (SD 24,184) for warfarin. For the 95 warfarin patients with INR values, time in therapeutic range averaged 70.4%. Conclusion: Compared to clinic-monitored warfarin, more men than women were prescribed new oral anticoagulants and these patients averaged a lower CHADS₂ score. After matching, patient adherence was high and comparable between groups. Anticoagulation control for warfarin patients was similar to clinical trials. Annual medication cost was significantly greater for new oral anticoagulants than clinic-monitored warfarin, including INR monitoring costs. Total annual all-cause healthcare costs were significantly greater for patients taking new oral anticoagulants compared to warfarin, although too few adverse events occurred to draw conclusions regarding event rates and costs of ischemic stroke and major bleeds. Advisors/Committee Members: Rascati, Karen L. (advisor), Wilson, James P. (advisor).

Subjects/Keywords: Atrial fibrillation; Warfarin; Oral anticoagulant

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APA (6^th Edition):

Hulvershorn, S. E. (2014). Outcomes and direct treatment costs with novel oral anticoagulants compared to clinic-monitored warfarin for stroke prevention in atrial fibrillation. (Thesis). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/26481

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hulvershorn, Sarah Elizabeth. “Outcomes and direct treatment costs with novel oral anticoagulants compared to clinic-monitored warfarin for stroke prevention in atrial fibrillation.” 2014. Thesis, University of Texas – Austin. Accessed July 22, 2019. http://hdl.handle.net/2152/26481.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hulvershorn, Sarah Elizabeth. “Outcomes and direct treatment costs with novel oral anticoagulants compared to clinic-monitored warfarin for stroke prevention in atrial fibrillation.” 2014. Web. 22 Jul 2019.

Vancouver:

Hulvershorn SE. Outcomes and direct treatment costs with novel oral anticoagulants compared to clinic-monitored warfarin for stroke prevention in atrial fibrillation. [Internet] [Thesis]. University of Texas – Austin; 2014. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/2152/26481.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hulvershorn SE. Outcomes and direct treatment costs with novel oral anticoagulants compared to clinic-monitored warfarin for stroke prevention in atrial fibrillation. [Thesis]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/26481

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

21. Izaddoustdar, Farzad. Mechanisms Underlying Exercise-induced Atrial Fibrillation.

Degree: 2013, University of Toronto

URL: http://hdl.handle.net/1807/35120

►

Atrial fibrillation (AF) is the most common supraventricular tachyarrhythmia that can present without cardiovascular disease (lone AF). Frequent high-intensity endurance exercise is a risk factor… (more)

Subjects/Keywords: atrial fibrillation; athletes; exercise; 0719

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APA (6^th Edition):

Izaddoustdar, F. (2013). Mechanisms Underlying Exercise-induced Atrial Fibrillation. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/35120

Chicago Manual of Style (16^th Edition):

Izaddoustdar, Farzad. “Mechanisms Underlying Exercise-induced Atrial Fibrillation.” 2013. Masters Thesis, University of Toronto. Accessed July 22, 2019. http://hdl.handle.net/1807/35120.

MLA Handbook (7^th Edition):

Izaddoustdar, Farzad. “Mechanisms Underlying Exercise-induced Atrial Fibrillation.” 2013. Web. 22 Jul 2019.

Vancouver:

Izaddoustdar F. Mechanisms Underlying Exercise-induced Atrial Fibrillation. [Internet] [Masters thesis]. University of Toronto; 2013. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/1807/35120.

Council of Science Editors:

Izaddoustdar F. Mechanisms Underlying Exercise-induced Atrial Fibrillation. [Masters Thesis]. University of Toronto; 2013. Available from: http://hdl.handle.net/1807/35120

22. Maan, Abhishek. Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the.

Degree: School of Public Health, 2018, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:792665/

► The United States Preventive Services Task Force (USPSTF) recommends aspirin for primary prevention of coronary artery disease (CAD) in adults aged 50-69 years. The objective… (more)

Subjects/Keywords: Aspirin; cardiovascular disease; atrial fibrillation

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APA (6^th Edition):

Maan, A. (2018). Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:792665/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Maan, Abhishek. “Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the.” 2018. Thesis, Brown University. Accessed July 22, 2019. https://repository.library.brown.edu/studio/item/bdr:792665/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Maan, Abhishek. “Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the.” 2018. Web. 22 Jul 2019.

Vancouver:

Maan A. Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the. [Internet] [Thesis]. Brown University; 2018. [cited 2019 Jul 22]. Available from: https://repository.library.brown.edu/studio/item/bdr:792665/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Maan A. Association Between Household Income and Aspirin Use for Primary Prevention of Coronary Artery Disease: Insights from the Behavioral Risk Factor Surveillance System (BRFSS) Database Comparison of Rate and Rhythm Control Treatment Strategies in the. [Thesis]. Brown University; 2018. Available from: https://repository.library.brown.edu/studio/item/bdr:792665/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Melbourne

23. MEDI, CAROLINE. The remodelled atrium: causes, and implications for curative ablation.

Degree: 2012, University of Melbourne

URL: http://hdl.handle.net/11343/37296

► Atrial fibrillation has been described as an evolving epidemic in the setting of an aging population. Ongoing research into the atrial substrate responsible for maintaining… (more)

Subjects/Keywords: atrial fibrillation; atrial arrhythmias; catheter ablation; atrial flutter; atrial tachycardia

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APA (6^th Edition):

MEDI, C. (2012). The remodelled atrium: causes, and implications for curative ablation. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/37296

Chicago Manual of Style (16^th Edition):

MEDI, CAROLINE. “The remodelled atrium: causes, and implications for curative ablation.” 2012. Doctoral Dissertation, University of Melbourne. Accessed July 22, 2019. http://hdl.handle.net/11343/37296.

MLA Handbook (7^th Edition):

MEDI, CAROLINE. “The remodelled atrium: causes, and implications for curative ablation.” 2012. Web. 22 Jul 2019.

Vancouver:

MEDI C. The remodelled atrium: causes, and implications for curative ablation. [Internet] [Doctoral dissertation]. University of Melbourne; 2012. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/11343/37296.

Council of Science Editors:

MEDI C. The remodelled atrium: causes, and implications for curative ablation. [Doctoral Dissertation]. University of Melbourne; 2012. Available from: http://hdl.handle.net/11343/37296

24. Hasegawa, Kanae. A Novel KCNQ1 Missense Mutation Identified in a Patient with Juvenile-Onset Atrial Fibrillation Causes Constitutively Open IKs Channels : 若年性心房細動患者に同定された新たなKCNQ1ミスセンス変異はIKsチャネルを持続的に開口させる.

Degree: 博士（医学）, 2014, Niigata University / 新潟大学

URL: http://hdl.handle.net/10191/27327

►

学位の種類: 博士（医学）. 報告番号: 甲第3861号. 学位記番号: 新大院博（医）甲第601号. 学位授与年月日: 平成26年3月24日

Heart Rhythm. 2014, 11(1), 67-75

Background: Atrial fibrillation (AF) is one of the most common cardiac arrhythmias,… (more)

▼

学位の種類: 博士（医学）. 報告番号: 甲第3861号. 学位記番号: 新大院博（医）甲第601号. 学位授与年月日: 平成26年3月24日

Heart Rhythm. 2014, 11(1), 67-75

Background: Atrial fibrillation (AF) is one of the most common cardiac arrhythmias, and in some patients, the disease is inheritable. Hereditary aspects of AF, however, remain not fully elucidated. Objective: The purpose of this study was to identify genetic backgrounds contributed to juvenile-onset AF and to define the mechanism. Methods: In 30 consecutive juvenile-onset AF patients (onset age <50 year-old), we screened AF-related genes (KCNQ1, KCNH2, KCNE1-3 and 5, KCNJ2, and SCN5A). We analyzed the function of mutant channels using whole-cell patch-clamp techniques and computer simulations. Results: Among the juvenile-onset AF patients, we identified three mutations (10%), SCN5A-M1875T, KCNJ2-M301K, and KCNQ1-G229D. Since KCNQ1 variant (G229) identified in a 16-year-old boy was novel, we focused on the proband. The G229D-IKs was found to induce a large instantaneous activating component without deactivation after repolarization to –50 mV. In addition, WT/G229D-IKs (WT and mutant co-expression) displayed both instantaneous and time-dependent activating currents. Compared to WT-IKs, the tail current densities in WT/G229D-IKs were larger at test potentials between –130 and –40 mV, but smaller at test potentials between 20 and 50 mV. Moreover, WT/G229D-IKs resulted in a negative voltage shift for current activation (−35.2 mV) and slower deactivation. WT/G229D-IKs conducted a large outward current Hasegawa et al. A novel KCNQ1 mutation in Juvenile-Onset AF 4 induced by an atrial action potential waveform, and computer simulation incorporating the WT/G229D-IKs results revealed that the mutation shortened atrial but not ventricular action potential. Conclusion: A novel KCNQ1-G229D mutation identified in a juvenile-onset AF patient altered the IKs activity and kinetics, thereby increasing the arrhythmogenicity to AF.

Subjects/Keywords: atrial fibrillation; juvenile-onset atrial fibrillation; ion channel; Iks; KCNQ1

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APA (6^th Edition):

Hasegawa, K. (2014). A Novel KCNQ1 Missense Mutation Identified in a Patient with Juvenile-Onset Atrial Fibrillation Causes Constitutively Open IKs Channels : 若年性心房細動患者に同定された新たなKCNQ1ミスセンス変異はIKsチャネルを持続的に開口させる. (Thesis). Niigata University / 新潟大学. Retrieved from http://hdl.handle.net/10191/27327

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hasegawa, Kanae. “A Novel KCNQ1 Missense Mutation Identified in a Patient with Juvenile-Onset Atrial Fibrillation Causes Constitutively Open IKs Channels : 若年性心房細動患者に同定された新たなKCNQ1ミスセンス変異はIKsチャネルを持続的に開口させる.” 2014. Thesis, Niigata University / 新潟大学. Accessed July 22, 2019. http://hdl.handle.net/10191/27327.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hasegawa, Kanae. “A Novel KCNQ1 Missense Mutation Identified in a Patient with Juvenile-Onset Atrial Fibrillation Causes Constitutively Open IKs Channels : 若年性心房細動患者に同定された新たなKCNQ1ミスセンス変異はIKsチャネルを持続的に開口させる.” 2014. Web. 22 Jul 2019.

Vancouver:

Hasegawa K. A Novel KCNQ1 Missense Mutation Identified in a Patient with Juvenile-Onset Atrial Fibrillation Causes Constitutively Open IKs Channels : 若年性心房細動患者に同定された新たなKCNQ1ミスセンス変異はIKsチャネルを持続的に開口させる. [Internet] [Thesis]. Niigata University / 新潟大学; 2014. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/10191/27327.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hasegawa K. A Novel KCNQ1 Missense Mutation Identified in a Patient with Juvenile-Onset Atrial Fibrillation Causes Constitutively Open IKs Channels : 若年性心房細動患者に同定された新たなKCNQ1ミスセンス変異はIKsチャネルを持続的に開口させる. [Thesis]. Niigata University / 新潟大学; 2014. Available from: http://hdl.handle.net/10191/27327

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Case Western Reserve University

25. Liu, Zhao. USING GENE THERAPY TO PREVENT ATRIAL FIBRILLATION.

Degree: PhD, Biomedical Engineering, 2017, Case Western Reserve University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=case1481231548493874

► Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Postoperative AF (POAF), a specific form of AF, is the most common complication after cardiac… (more)

▼ Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. Postoperative AF (POAF), a specific form of AF, is the most common complication after cardiac surgery. Current therapies are suboptimal with a limited efficacy and significant toxicity, suggesting the need to develop novel and more effective therapies. Gene therapy becomes an attractive alternative to prevent or ablate AF. AF is considered to be sustained by reentrant mechanisms that are promoted by atrial remodeling. We studied the two major forms of atrial remodeling: structural and electrical remodeling. Calcium/calmodulin-dependent protein kinase II (CaMKII) plays a role in structural remodeling in several tissues, but its role in sustaining AF remains undefined. We tested the hypothesis that increased CaMKII activity is a cause of structural remodeling in AF. We assessed the effects of CaMKII inhibition in our porcine AF-heart failure model after atrial gene transfer with an adenovirus encoding a potent and specific inhibitor of CaMKII (the inhibitory peptide CaMKIIn). Inhibition of CaMKII preserved atrial contractile function and attenuated atrial structural remodeling, including hypertrophy, fibrosis and apoptosis but did not affect inflammation or myolysis. These observations were accompanied by significantly decreased phosphorylation of HDAC4 and decreased expression of p38MAP-Kinase, but no change in JNK or ERK1/2. Action potential duration (APD) shortening is an important aspect of electrical remodeling. Our previous work showed that KCNH2-G628S gene therapy eliminated AF by prolonging APD. In this study, we examined the efficacy and safety of KCNH2-G628S gene therapy to prevent POAF. We found that the gene transfer reduced AF burden without any evident toxicity in extensive safety analysis. The timing of adenovirus-mediated gene expression is such that the method can be directly applicable to prevent POAF, which supports further study in a Phase I clinical trial. Furthermore, to improve the efficiency and accuracy of histological analysis, we developed and validated automatic and semi-automatic image processing algorithms. In summary, this work demonstrated that in a clinically relevant large mammalian model of persistent AF and heart failure, gene therapy successfully disrupted atrial structural and electrical remodeling and prevented AF. Advisors/Committee Members: Donahue, J. Kevin (Advisor), Rollins, Andrew (Committee Chair).

Subjects/Keywords: Biomedical Engineering; Atrial fibrillation; gene therapy; atrial remodeling; CaMKII; post-operative atrial fibrillation; electrophysiology; KCNH2

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Liu, Z. (2017). USING GENE THERAPY TO PREVENT ATRIAL FIBRILLATION. (Doctoral Dissertation). Case Western Reserve University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=case1481231548493874

Chicago Manual of Style (16^th Edition):

Liu, Zhao. “USING GENE THERAPY TO PREVENT ATRIAL FIBRILLATION.” 2017. Doctoral Dissertation, Case Western Reserve University. Accessed July 22, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1481231548493874.

MLA Handbook (7^th Edition):

Liu, Zhao. “USING GENE THERAPY TO PREVENT ATRIAL FIBRILLATION.” 2017. Web. 22 Jul 2019.

Vancouver:

Liu Z. USING GENE THERAPY TO PREVENT ATRIAL FIBRILLATION. [Internet] [Doctoral dissertation]. Case Western Reserve University; 2017. [cited 2019 Jul 22]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1481231548493874.

Council of Science Editors:

Liu Z. USING GENE THERAPY TO PREVENT ATRIAL FIBRILLATION. [Doctoral Dissertation]. Case Western Reserve University; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=case1481231548493874

University of Oulu

26. Junttila, J. (Juhani). Characteristics of subjects with Brugada syndrome type electrocardiogram.

Degree: 2008, University of Oulu

URL: http://urn.fi/urn:isbn:9789514287701

► Abstract Brugada syndrome is an inherited arrhythmia disorder that predisposes to sudden cardiac death. It is characterized by its distinct ECG pattern. The purpose of… (more)

▼ Abstract Brugada syndrome is an inherited arrhythmia disorder that predisposes to sudden cardiac death. It is characterized by its distinct ECG pattern. The purpose of this thesis was to study the phenotype and genotype characteristics of subjects with Brugada syndrome type ECG. The first study population consisted of 2479 young male Air Force applicants and 542 healthy middle-aged subjects. The 12-lead ECG was analyzed to assess the prevalence and prognosis of Brugada pattern in Finnish population. The second population consisted of 168 patients with AF. The ECGs of the patients with family history of lone AF were analysed in order to characterize the ECG features of familial AF. The third population consisted of 200 patients with Brugada syndrome and their ECGs were analyzed for detection of distinct ECG characteristics. In a substudy, the H558R variant was genotyped and the clinical presentation of this variant was evaluated. The clinical characteristics were collected of 47 patients with induced Brugada ECG during fever or medication. The prevalence of type 2 or 3 Brugada ECG was 0.61% in the young population and 0.55% in the middle-aged Finnish population. In a retrospective analysis, none of the Brugada ECG carriers had died. In the AF study, the prevalence of type 2 or 3 Brugada ECG was significantly higher among the subjects with lone AF compared to the healthy controls (p < 0.001). Many of the Brugada ECG carriers had a family history (> 30% of first-degree relatives) of AF. In patients with Brugada syndrome, the prolonged QRS duration was associated with previous symptoms. The R allele carriers in H558R variant had a trend towards less symptoms (p = 0.067) and had less conduction disturbances in 12-lead ECG than the HH genotype carriers (p < 0.05 in all ECG analysis). Among the subjects with induced Brugada ECG, 51% exhibited arrhythmic symptoms during the medical condition that had provoked the ECG pattern. In conclusion, type 2 and 3 Brugada ECGs were found to be benign in the Finnish population since no mortality occurred during an extensive follow-up period. On the other hand, these ECG abnormalities seem to be a marker of familial AF. Among patients with the Brugada syndrome, a prolongation of QRS is associated with prior symptoms. The variant H558R R allele seems to be a protecting genetic modulator. Induced Brugada ECG is a medical emergency since the patients are at high risk of sudden cardiac death.

Subjects/Keywords: Atrial Fibrillation; Brugada syndrome; ECG; genetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Junttila, J. (. (2008). Characteristics of subjects with Brugada syndrome type electrocardiogram. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789514287701

Chicago Manual of Style (16^th Edition):

Junttila, J (Juhani). “Characteristics of subjects with Brugada syndrome type electrocardiogram.” 2008. Doctoral Dissertation, University of Oulu. Accessed July 22, 2019. http://urn.fi/urn:isbn:9789514287701.

MLA Handbook (7^th Edition):

Junttila, J (Juhani). “Characteristics of subjects with Brugada syndrome type electrocardiogram.” 2008. Web. 22 Jul 2019.

Vancouver:

Junttila J(. Characteristics of subjects with Brugada syndrome type electrocardiogram. [Internet] [Doctoral dissertation]. University of Oulu; 2008. [cited 2019 Jul 22]. Available from: http://urn.fi/urn:isbn:9789514287701.

Council of Science Editors:

Junttila J(. Characteristics of subjects with Brugada syndrome type electrocardiogram. [Doctoral Dissertation]. University of Oulu; 2008. Available from: http://urn.fi/urn:isbn:9789514287701

Univerzitet u Beogradu

27. Pađen, Višnja V., 1982-. Akutni ishemijski moždani udar kod bolesnika sa atrijalnom fibrilacijom : kliničke karakteristike i ishod.

Degree: Medicinski fakultet, 2015, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:9685/bdef:Content/get

►

Medicina / Medicine

Cilj: Atrijalna fibrilacija (AF) predstavlja nezavisni faktor koji pet puta povećava rizik od nastanka akutnog ishemijskog moždanog udara (AIMU). Takodje, ona predstavlja… (more)

Subjects/Keywords: atrial fibrillation; stroke; baseline characteristics; outcomes; thrombolysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pađen, Višnja V., 1. (2015). Akutni ishemijski moždani udar kod bolesnika sa atrijalnom fibrilacijom : kliničke karakteristike i ishod. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:9685/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Pađen, Višnja V., 1982-. “Akutni ishemijski moždani udar kod bolesnika sa atrijalnom fibrilacijom : kliničke karakteristike i ishod.” 2015. Thesis, Univerzitet u Beogradu. Accessed July 22, 2019. https://fedorabg.bg.ac.rs/fedora/get/o:9685/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Pađen, Višnja V., 1982-. “Akutni ishemijski moždani udar kod bolesnika sa atrijalnom fibrilacijom : kliničke karakteristike i ishod.” 2015. Web. 22 Jul 2019.

Vancouver:

Pađen, Višnja V. 1. Akutni ishemijski moždani udar kod bolesnika sa atrijalnom fibrilacijom : kliničke karakteristike i ishod. [Internet] [Thesis]. Univerzitet u Beogradu; 2015. [cited 2019 Jul 22]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:9685/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Pađen, Višnja V. 1. Akutni ishemijski moždani udar kod bolesnika sa atrijalnom fibrilacijom : kliničke karakteristike i ishod. [Thesis]. Univerzitet u Beogradu; 2015. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:9685/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. 福井, 暁. Role of Leptin Signaling in the Pathogenesis of Angiotensin II-Mediated Atrial Fibrosis and Fibrillation.

Degree: 博士(医学), 2016, Oita University / 大分大学

URL: http://hdl.handle.net/10559/15626

►

Background: We examined the hypothesis that leptin signaling contributes to the atrial fibrosis and atrial fibrillation (AF) evoked by angiotensin II (AngII).

Methods and Results:… (more)

Subjects/Keywords: atrial fibrillation; angiotensin; collagen; electrophysiology; pathology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

福井, �. (2016). Role of Leptin Signaling in the Pathogenesis of Angiotensin II-Mediated Atrial Fibrosis and Fibrillation. (Thesis). Oita University / 大分大学. Retrieved from http://hdl.handle.net/10559/15626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

福井, 暁. “Role of Leptin Signaling in the Pathogenesis of Angiotensin II-Mediated Atrial Fibrosis and Fibrillation.” 2016. Thesis, Oita University / 大分大学. Accessed July 22, 2019. http://hdl.handle.net/10559/15626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

福井, 暁. “Role of Leptin Signaling in the Pathogenesis of Angiotensin II-Mediated Atrial Fibrosis and Fibrillation.” 2016. Web. 22 Jul 2019.

Vancouver:

福井 �. Role of Leptin Signaling in the Pathogenesis of Angiotensin II-Mediated Atrial Fibrosis and Fibrillation. [Internet] [Thesis]. Oita University / 大分大学; 2016. [cited 2019 Jul 22]. Available from: http://hdl.handle.net/10559/15626.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

福井 �. Role of Leptin Signaling in the Pathogenesis of Angiotensin II-Mediated Atrial Fibrosis and Fibrillation. [Thesis]. Oita University / 大分大学; 2016. Available from: http://hdl.handle.net/10559/15626

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

29. 駱毅生; Lok, Ngai-sang. Determinants and new therapeutic strategy of atrial fibrillation.

Degree: M. Phil., 1997, University of Hong Kong

URL: Lok, N. [駱毅生]. (1997). Determinants and new therapeutic strategy of atrial fibrillation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b3121438 ; http://dx.doi.org/10.5353/th_b3121438 ; http://hdl.handle.net/10722/33946

published_or_final_version

Medicine

Master

Master of Philosophy

Subjects/Keywords: Atrial fibrillation - Treatment.

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APA (6^th Edition):

駱毅生; Lok, N. (1997). Determinants and new therapeutic strategy of atrial fibrillation. (Masters Thesis). University of Hong Kong. Retrieved from Lok, N. [駱毅生]. (1997). Determinants and new therapeutic strategy of atrial fibrillation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b3121438 ; http://dx.doi.org/10.5353/th_b3121438 ; http://hdl.handle.net/10722/33946

Chicago Manual of Style (16^th Edition):

駱毅生; Lok, Ngai-sang. “Determinants and new therapeutic strategy of atrial fibrillation.” 1997. Masters Thesis, University of Hong Kong. Accessed July 22, 2019. Lok, N. [駱毅生]. (1997). Determinants and new therapeutic strategy of atrial fibrillation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b3121438 ; http://dx.doi.org/10.5353/th_b3121438 ; http://hdl.handle.net/10722/33946.

MLA Handbook (7^th Edition):

駱毅生; Lok, Ngai-sang. “Determinants and new therapeutic strategy of atrial fibrillation.” 1997. Web. 22 Jul 2019.

Vancouver:

駱毅生; Lok N. Determinants and new therapeutic strategy of atrial fibrillation. [Internet] [Masters thesis]. University of Hong Kong; 1997. [cited 2019 Jul 22]. Available from: Lok, N. [駱毅生]. (1997). Determinants and new therapeutic strategy of atrial fibrillation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b3121438 ; http://dx.doi.org/10.5353/th_b3121438 ; http://hdl.handle.net/10722/33946.

Council of Science Editors:

駱毅生; Lok N. Determinants and new therapeutic strategy of atrial fibrillation. [Masters Thesis]. University of Hong Kong; 1997. Available from: Lok, N. [駱毅生]. (1997). Determinants and new therapeutic strategy of atrial fibrillation. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b3121438 ; http://dx.doi.org/10.5353/th_b3121438 ; http://hdl.handle.net/10722/33946

Kent State University

30. Ram, Rashmi. Expression and Phosphorylation of Left Atrial Connexin 43 in Human and Experimental Atrial Fibrillation.

Degree: PhD, College of Arts and Sciences / School of Biomedical Sciences, 2008, Kent State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=kent1228141040

► Background: Atrial fibrillation (AF) is a prevalent and increasingly common arrhythmia that increases risk of stroke and death. Electrical and structural remodeling processes contribute to… (more)

▼ Background: Atrial fibrillation (AF) is a prevalent and increasingly common arrhythmia that increases risk of stroke and death. Electrical and structural remodeling processes contribute to the development of persistent AF. Remodeling promotes heterogeneous ion channel activity and conduction that form a substrate for re-entrant activity. Connexins are proteins that underlie conduction between myocytes; conduction is regulated by connexin expression and phosphorylation. Connexin 43 (Cx43) is the most abundant cardiac connexin. We tested the hypothesis that left atrial (LA) expression and/or phosphorylation of Cx43 is dynamically modulated in human AF, and in two animal models of AF. Methods: Histologic, confocal and western analyses were performed to examine the expression, phosphorylation and distribution of Cx43 in LA tissues from cardiac surgery patients (i) with or without a history of AF, (ii) in sinus rhythm or AF at surgery. Left and right atrial Cx43 expression, distribution and phosphorylation was also evaluated in a goat model of short- and long-term AF, and in a canine model of post-surgical AF. Results: Our studies demonstrate that: (i) atrial rhythm acutely modulates Cx43 expression and phosphorylation, (ii) Cx43 expression tends to increase within three weeks of AF, and redistributes to the lateral surface of myocytes with prolonged AF, (iii) Cx43 is present not only in the intercalated disk, but also in the mitochondria of both human and canine atria, (iv) C-reactive protein is detectable in the LA of patients with human AF, and its presence reflects current rhythm, (v) inflammation in the setting of post-operative AF modulates Cx43 expression and phosphorylation differently in left and right atria, and (vi) dietary supplementation with ¿3-PUFAs attenuates basal Cx43 expression and phosphorylation, likely enhancing the safety factor of conduction, thus limiting arrhythmia inducibility. Conclusions: Cx43 expression and phosphorylation are dynamically modulated by stresses imposed by abnormal hemodynamics, autonomic tone, heart rate and inflammation. Redistribution of Cx43 likely affects the anisotropic properties of atrial conduction, and contributes to the development of persistent atrial fibrillation. Expression of Cx43 in cardiac mitochondria suggests that it may have additional important functions within the myocyte, beyond its widely appreciated role as mediator of cell-to-cell coupling. Advisors/Committee Members: Van Wagoner, David R. (Advisor).

Subjects/Keywords: Biomedical Research; Connexin 43; Inflammation; Atrial Fibrillation

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APA (6^th Edition):

Ram, R. (2008). Expression and Phosphorylation of Left Atrial Connexin 43 in Human and Experimental Atrial Fibrillation. (Doctoral Dissertation). Kent State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=kent1228141040

Chicago Manual of Style (16^th Edition):

Ram, Rashmi. “Expression and Phosphorylation of Left Atrial Connexin 43 in Human and Experimental Atrial Fibrillation.” 2008. Doctoral Dissertation, Kent State University. Accessed July 22, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=kent1228141040.

MLA Handbook (7^th Edition):

Ram, Rashmi. “Expression and Phosphorylation of Left Atrial Connexin 43 in Human and Experimental Atrial Fibrillation.” 2008. Web. 22 Jul 2019.

Vancouver:

Ram R. Expression and Phosphorylation of Left Atrial Connexin 43 in Human and Experimental Atrial Fibrillation. [Internet] [Doctoral dissertation]. Kent State University; 2008. [cited 2019 Jul 22]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1228141040.

Council of Science Editors:

Ram R. Expression and Phosphorylation of Left Atrial Connexin 43 in Human and Experimental Atrial Fibrillation. [Doctoral Dissertation]. Kent State University; 2008. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=kent1228141040

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Open Access Theses and Dissertations