subject:(Asymmetric catalysis)

University of Oxford

1. Maciver, Eleanor E. Asymmetric electrocyclic reactions.

Degree: PhD, 2013, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:17ba3cb0-0c62-406a-bed4-14c410a45918 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588436

► Pericyclic reactions are a class of transformations that comprise sigmatropic rearrangements, group transfer reactions, cycloadditions and electrocyclic reactions. Since Woodward and Hoffmann rationalized the mechanism… (more)

Subjects/Keywords: 547; Asymmetric catalysis; Electrocyclization; Asymmetric; Catalysis

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APA (6^th Edition):

Maciver, E. E. (2013). Asymmetric electrocyclic reactions. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:17ba3cb0-0c62-406a-bed4-14c410a45918 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588436

Chicago Manual of Style (16^th Edition):

Maciver, Eleanor E. “Asymmetric electrocyclic reactions.” 2013. Doctoral Dissertation, University of Oxford. Accessed March 04, 2021. http://ora.ox.ac.uk/objects/uuid:17ba3cb0-0c62-406a-bed4-14c410a45918 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588436.

MLA Handbook (7^th Edition):

Maciver, Eleanor E. “Asymmetric electrocyclic reactions.” 2013. Web. 04 Mar 2021.

Vancouver:

Maciver EE. Asymmetric electrocyclic reactions. [Internet] [Doctoral dissertation]. University of Oxford; 2013. [cited 2021 Mar 04]. Available from: http://ora.ox.ac.uk/objects/uuid:17ba3cb0-0c62-406a-bed4-14c410a45918 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588436.

Council of Science Editors:

Maciver EE. Asymmetric electrocyclic reactions. [Doctoral Dissertation]. University of Oxford; 2013. Available from: http://ora.ox.ac.uk/objects/uuid:17ba3cb0-0c62-406a-bed4-14c410a45918 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.588436

University of Notre Dame

2. Eric C. Hansen. Development and Applications of Quantum to Molecular Mechanics (Q2MM)</h1>.

Degree: Chemistry and Biochemistry, 2017, University of Notre Dame

URL: https://curate.nd.edu/show/wd375t37h4h

► Asymmetric synthesis is a major focus in modern organic chemistry. Experimentally screening for selective ligands is a cumbersome process, and provides only indirect insight… (more)

Subjects/Keywords: Chemistry; Asymmetric catalysis

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APA (6^th Edition):

Hansen, E. C. (2017). Development and Applications of Quantum to Molecular Mechanics (Q2MM)</h1>. (Thesis). University of Notre Dame. Retrieved from https://curate.nd.edu/show/wd375t37h4h

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hansen, Eric C.. “Development and Applications of Quantum to Molecular Mechanics (Q2MM)</h1>.” 2017. Thesis, University of Notre Dame. Accessed March 04, 2021. https://curate.nd.edu/show/wd375t37h4h.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hansen, Eric C.. “Development and Applications of Quantum to Molecular Mechanics (Q2MM)</h1>.” 2017. Web. 04 Mar 2021.

Vancouver:

Hansen EC. Development and Applications of Quantum to Molecular Mechanics (Q2MM)</h1>. [Internet] [Thesis]. University of Notre Dame; 2017. [cited 2021 Mar 04]. Available from: https://curate.nd.edu/show/wd375t37h4h.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hansen EC. Development and Applications of Quantum to Molecular Mechanics (Q2MM)</h1>. [Thesis]. University of Notre Dame; 2017. Available from: https://curate.nd.edu/show/wd375t37h4h

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brock University

3. Zaifman, Joshua David. Stereoselective synthesis of substituted hexahydro-3a,4a-diazacyclopentaphenanthren-4-ones and aminoferrocenes .

Degree: Department of Chemistry, 2011, Brock University

URL: http://hdl.handle.net/10464/3383

► This thesis explored the development of several methodologies for the stereoselective construction of ligand frameworks and some of their applications. The first segment concerns the… (more)

▼ This thesis explored the development of several methodologies for the stereoselective construction of ligand frameworks and some of their applications. The first segment concerns the application of an enantioselective lithiation at an Sp3_ hybridized position adjacent to nitrogen by means of the widely used and typically highly effective enantioselective lithiation with ( -)-sparteine. This investigation was intended to develop a method to install chirality into a system that would be converted into a family of diaminoylidenes for use as phosphine mimics in transition metal catalysis or as nucleophilic reagents. Molecular modeling of the system revealed some key interactions between the substrate and (-)-sparteine that provided general insight into the diamine's mode of action and should lend some predictive value to its future applications. The second portion focuses on the development of methods to access 1,2- disubstituted aminoferrocenes, an underexplored class of metallocenes possessing planar chirality. Two routes were examined involving a diastereoselective and an enantioselective pathway, where the latter method made use of the first BF3-mediated lithiation-substitution to install planar chirality. Key derivatives such as 1,2- aminophosphines, made readily accessible by the new route, were evaluated as ligands for Pd(II), Pt(II) and Ir(I). These complexes show activity in a number of transformations with both achiral and prochiral substrates. Optimization experiments were conducted to prepare enantiomerically enriched 2-substituted-I-aminoferrocenes by direct asymmetric lithiation of BF3-coordinated tertiary aminoferrocenes. A predictive computational model describing the transition state of this reaction was developed in collaboration with Professor Travis Dudding's group (Department of Chemistry, Brock University). The predicted stereochemistry of the process was confirmed by single-crystal X-ray analysis of a 2-phosphino-l-dimethylaminoferrocene derivative. Enantiomerically pure samples of the aminophosphine ligands derived from this new process have given promising preliminary results in the enantioselective hydrogenation of prochiral alkenes and warrant further stUdy in metal-mediated catalysis.

Subjects/Keywords: Asymmetric synthesis; Catalysis

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APA (6^th Edition):

Zaifman, J. D. (2011). Stereoselective synthesis of substituted hexahydro-3a,4a-diazacyclopentaphenanthren-4-ones and aminoferrocenes . (Thesis). Brock University. Retrieved from http://hdl.handle.net/10464/3383

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zaifman, Joshua David. “Stereoselective synthesis of substituted hexahydro-3a,4a-diazacyclopentaphenanthren-4-ones and aminoferrocenes .” 2011. Thesis, Brock University. Accessed March 04, 2021. http://hdl.handle.net/10464/3383.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zaifman, Joshua David. “Stereoselective synthesis of substituted hexahydro-3a,4a-diazacyclopentaphenanthren-4-ones and aminoferrocenes .” 2011. Web. 04 Mar 2021.

Vancouver:

Zaifman JD. Stereoselective synthesis of substituted hexahydro-3a,4a-diazacyclopentaphenanthren-4-ones and aminoferrocenes . [Internet] [Thesis]. Brock University; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10464/3383.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zaifman JD. Stereoselective synthesis of substituted hexahydro-3a,4a-diazacyclopentaphenanthren-4-ones and aminoferrocenes . [Thesis]. Brock University; 2011. Available from: http://hdl.handle.net/10464/3383

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of St. Andrews

4. Noonan, Gary M. Asymmetric hydroformylation : a powerful tool for the synthesis of pharmaceutical intermediates .

Degree: 2011, University of St. Andrews

URL: http://hdl.handle.net/10023/3105

► The hydroformylation of unfunctionalised olefins (such as prop-1-ene and oct-1-ene) is an extremely valuable process and is practised on a massive scale industrially in the… (more)

▼ The hydroformylation of unfunctionalised olefins (such as prop-1-ene and oct-1-ene) is an extremely valuable process and is practised on a massive scale industrially in the synthesis of commodity chemicals. In fact, it represents the worlds largest scale application of homogeneous catalysis. As a result, the majority of research carried out on this reaction has been in the study of catalytic systems which provide high rates and selectivity for the production of linear aldehydes from terminal unfunctionalised olefins, with the products finding use in the production of plasticizers and detergents. Asymmetric hydroformylation, the enantioselective variant of this reaction is extremely attractive, as low cost or easily accessible olefins are transformed into highly versatile value-added enantioenriched aldehydes in a single step. However synthetic organic chemists interested in the synthesis of fine chemicals, both in academia and industry, have been slow to adopt this attractive protocol for the production of chiral aldehydes. This is mainly due to the fact that in the past catalysts for this reaction exhibited low activity and/or selectivity in this process. However, the last two decades have seen major advances, mainly in the development of highly effective chiral ligands, and with these developments the time has come to tackle the vastly under-explored area of asymmetric hydroformylation of more functionalised olefins. To set the scene for the research carried out during this project a brief introduction will be given which highlights the historical development of highly efficient catalysts for the hydroformylation of olefins. This will be accompanied by some examples of the use of this methodology in the synthesis of pharmaceutically relevant compounds. It should become apparent from the introduction that the asymmetric hydroformylation of functionalised olefins and in particular nitrogen containing olefins, has received very little attention despite the fact that over half of all medicinal compounds contain at least one nitrogen containing functional group. Firstly we describe hydroformylation as a useful alternative to the classical synthesis of a delicate chiral building block, namely α-formyl amides. These compounds, traditionally only available through multi-step synthetic procedures from enantiopure starting materials, have been accessed by asymmetric hydroformylation of readily accessible and in some cases commercially available acrylamides. By judicious choice of reaction conditions and selection of the appropriately active chiral ligand enantioenriched α-formyl amides (e.e. up to 82%) were produced in high yield. A comparison is made between the classical route and the hydroformylation route to illustrate the potential of this efficient transformation. We have studied the hydroformylation of enamides, a much under-studied substrate class in hydroformylation and developed knowledge of how some more functionalised 1,1- and 1-2-subtituted olefinic amides react under… Advisors/Committee Members: Clarke, Matt (advisor).

Subjects/Keywords: Catalysis; Asymmetric hydroformylation; Asymmetric synthesis; Green chemistry

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APA (6^th Edition):

Noonan, G. M. (2011). Asymmetric hydroformylation : a powerful tool for the synthesis of pharmaceutical intermediates . (Thesis). University of St. Andrews. Retrieved from http://hdl.handle.net/10023/3105

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Noonan, Gary M. “Asymmetric hydroformylation : a powerful tool for the synthesis of pharmaceutical intermediates .” 2011. Thesis, University of St. Andrews. Accessed March 04, 2021. http://hdl.handle.net/10023/3105.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Noonan, Gary M. “Asymmetric hydroformylation : a powerful tool for the synthesis of pharmaceutical intermediates .” 2011. Web. 04 Mar 2021.

Vancouver:

Noonan GM. Asymmetric hydroformylation : a powerful tool for the synthesis of pharmaceutical intermediates . [Internet] [Thesis]. University of St. Andrews; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10023/3105.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Noonan GM. Asymmetric hydroformylation : a powerful tool for the synthesis of pharmaceutical intermediates . [Thesis]. University of St. Andrews; 2011. Available from: http://hdl.handle.net/10023/3105

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

5. Brown, Casey Jameson. Asymmetric and Organometallic Catalysis Mediated by a Chiral Supramolecular Host.

Degree: Chemistry, 2011, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/7jv7m4wh

► Chapter 1. An overview of supramolecular catalysis is presented with attention to the diverse strategies used in developing these materials. Different strategies for the design… (more)

Subjects/Keywords: Chemistry; asymmetric; catalysis; organometallic; supramolecular

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APA (6^th Edition):

Brown, C. J. (2011). Asymmetric and Organometallic Catalysis Mediated by a Chiral Supramolecular Host. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/7jv7m4wh

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brown, Casey Jameson. “Asymmetric and Organometallic Catalysis Mediated by a Chiral Supramolecular Host.” 2011. Thesis, University of California – Berkeley. Accessed March 04, 2021. http://www.escholarship.org/uc/item/7jv7m4wh.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brown, Casey Jameson. “Asymmetric and Organometallic Catalysis Mediated by a Chiral Supramolecular Host.” 2011. Web. 04 Mar 2021.

Vancouver:

Brown CJ. Asymmetric and Organometallic Catalysis Mediated by a Chiral Supramolecular Host. [Internet] [Thesis]. University of California – Berkeley; 2011. [cited 2021 Mar 04]. Available from: http://www.escholarship.org/uc/item/7jv7m4wh.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brown CJ. Asymmetric and Organometallic Catalysis Mediated by a Chiral Supramolecular Host. [Thesis]. University of California – Berkeley; 2011. Available from: http://www.escholarship.org/uc/item/7jv7m4wh

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

6. Ghosh, Subrata Kumar. The Development of New Classes of Enantioselective Hydrogen Bond Donor Catalysts for Organic Synthesis Based upon Werner Complexes.

Degree: PhD, Chemistry, 2017, Texas A&M University

URL: http://hdl.handle.net/1969.1/169551

► In this dissertation, the development of highly effective, chiral monofunctional and bifunctional hydrogen bond donor catalysts based on cobalt(III) Werner complexes and their applications in… (more)

▼ In this dissertation, the development of highly effective, chiral monofunctional and bifunctional hydrogen bond donor catalysts based on cobalt(III) Werner complexes and their applications in enantioselective catalysis have been described. Furthermore, a protocol was developed to extend this chemistry into the fluorous media. Section 1 provides an overview of the hydrogen bond mediated organocatalysis and the scope of Werner complexes as hydrogen bond donors. Section 2 describes the fundamental stereochemical features of the trication [Co(en)3]3+ (en = ethylenediamine). Interactions between the trication, counter anions, and solvates are analyzed and a systematic nomenclature is developed. Section 3 provides highly diastereoselective syntheses of variety of diastereopure salts Λ- and Δ-[Co((S,S)-NHv2CHArCHArNHv2)v3]³⁺ 2X–X'– (Ar = Cv6Hv5, vCv6Hv4n-Bu, 4- Cv6Hv4Cl, 4-Cv6Hv4CFv3, 4-Cv6Hv4OCHv3, ɑ-naphthyl, ß-naphthyl, 2-Cv6Hv4OBn; X/X' = Cl/BArvf (BArvf = B(3,5-Cv6Hv3(CFv3)v2)v4), PFv6/BArf, BF4/BArf, PhBF3/BArf, Cl/BArf20 (BArvf20 = B(Cv6F5)4), BArf/BArf, BArf20/BArvf20, BFv4/BFv4, PFv6/PFv6) and probes their properties. Sections 4 and 5 provide detail applications of the lipophilic salts of Λ- or Δ- [Co((S,S)-dpen)v3]³⁺ ((S,S)-dpen = (S,S)-1,2-diphenylethylenediamine) in enantioselective addition reactions. Under optimized conditions, Λ-[Co((S,S)-dpen)v3]³⁺ 3BFv4– catalyzes the Michael addition of dialkyl malonate to nitroalkenes in the presence of Et3N, affording adducts in up to 98% yields and 96% ee. Interestingly, Δ-[Co((S,S)- dpen)v3]³⁺ 2Cl–BArvf20– is superior for the additions of cyclic ß-ketoesters to azodicarboylate diesters (up to 99% yields and >99% ee). Section 6 describes efficient syntheses of tris(hydrochloric acid) salts of chiral triamines Hv2NCH((CHv2)nNMe2)CHv2NHv2 (n = 1-4) from commercial starting materials in overall yields of 38-18%. Section 7 highlights syntheses of bifunctional catalysts and their applications in additions of dialkyl malonates to nitroalkenes. Racemic [Co(en)v2Ov2CO]⁺ Cl^– and enantiopure (S)-[Hv3NCH((CH2)nNHMe2)CHv2NHv3]³⁺ 3Cl^– (n = 1-4) are combined (water/ charcoal/100 °C) to give [Co(en)v2((S)-Hv2NCH((CHv2)vnNMev2H)CHv2NHv2)]4⁺ 4Cl^–. The cobalt diastereomers (Δ/Δ)are separated via chiral Sephadex columns. Reactions with NaOH and Na⁺ BArvf^– give the catalysts Λ- or Δ-[Co(en)v2((S)-Hv2NCH- ((CHv2)nNMev2)CHv2NHv2)]³⁺ 3BArvf^–. Under optimized condition, Λ-[Co(en)v2((S)- Hv2NCH((CHv2)v3NMev2)CHv2NHv2)]³⁺ 3BArvf^– gives addition products up to 98% yield and 99% ee. Section 8 describes an optimized procedure for the synthesis of highly fluorous Na⁺ B(3,5-Cv6Hv3((CFv2)5CFv3)v2)v4– and its application in transporting polycations into fluorous media. Advisors/Committee Members: Gladysz, John A (advisor), Singleton, Daniel A (committee member), Darensbourg, Donald J (committee member), Tarone, Aaron M (committee member).

Subjects/Keywords: Chiral; asymmetric; catalysis; cobalt; fluorous

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ghosh, S. K. (2017). The Development of New Classes of Enantioselective Hydrogen Bond Donor Catalysts for Organic Synthesis Based upon Werner Complexes. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/169551

Chicago Manual of Style (16^th Edition):

Ghosh, Subrata Kumar. “The Development of New Classes of Enantioselective Hydrogen Bond Donor Catalysts for Organic Synthesis Based upon Werner Complexes.” 2017. Doctoral Dissertation, Texas A&M University. Accessed March 04, 2021. http://hdl.handle.net/1969.1/169551.

MLA Handbook (7^th Edition):

Ghosh, Subrata Kumar. “The Development of New Classes of Enantioselective Hydrogen Bond Donor Catalysts for Organic Synthesis Based upon Werner Complexes.” 2017. Web. 04 Mar 2021.

Vancouver:

Ghosh SK. The Development of New Classes of Enantioselective Hydrogen Bond Donor Catalysts for Organic Synthesis Based upon Werner Complexes. [Internet] [Doctoral dissertation]. Texas A&M University; 2017. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1969.1/169551.

Council of Science Editors:

Ghosh SK. The Development of New Classes of Enantioselective Hydrogen Bond Donor Catalysts for Organic Synthesis Based upon Werner Complexes. [Doctoral Dissertation]. Texas A&M University; 2017. Available from: http://hdl.handle.net/1969.1/169551

Colorado State University

7. White, Nicholas Andrew. Enantioselective β-functionalization of enals via N-heterocyclic carbene catalysis.

Degree: PhD, Chemistry, 2015, Colorado State University

URL: http://hdl.handle.net/10217/170358

► A series of δ-nitroesters were synthesized through the N-heterocyclic carbene catalyzed coupling of enals and nitroalkenes. The asymmetric coupling of these substrates via the homoenolate… (more)

Subjects/Keywords: asymmetric; carbene; catalysis; organic

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APA (6^th Edition):

White, N. A. (2015). Enantioselective β-functionalization of enals via N-heterocyclic carbene catalysis. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/170358

Chicago Manual of Style (16^th Edition):

White, Nicholas Andrew. “Enantioselective β-functionalization of enals via N-heterocyclic carbene catalysis.” 2015. Doctoral Dissertation, Colorado State University. Accessed March 04, 2021. http://hdl.handle.net/10217/170358.

MLA Handbook (7^th Edition):

White, Nicholas Andrew. “Enantioselective β-functionalization of enals via N-heterocyclic carbene catalysis.” 2015. Web. 04 Mar 2021.

Vancouver:

White NA. Enantioselective β-functionalization of enals via N-heterocyclic carbene catalysis. [Internet] [Doctoral dissertation]. Colorado State University; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10217/170358.

Council of Science Editors:

White NA. Enantioselective β-functionalization of enals via N-heterocyclic carbene catalysis. [Doctoral Dissertation]. Colorado State University; 2015. Available from: http://hdl.handle.net/10217/170358

Rice University

8. Sambasivan, Ramya. Rh(II) metallopeptides for asymmetric catalysis.

Degree: PhD, Natural Sciences, 2015, Rice University

URL: http://hdl.handle.net/1911/95526

► The development of peptides as chiral ligands for asymmetric Rh(II) catalysis is discussed in this work. Mother Nature’s solution to chiral ligand design is to… (more)

Subjects/Keywords: metallopeptide; asymmetric catalysis; rhodium catalyst

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APA (6^th Edition):

Sambasivan, R. (2015). Rh(II) metallopeptides for asymmetric catalysis. (Doctoral Dissertation). Rice University. Retrieved from http://hdl.handle.net/1911/95526

Chicago Manual of Style (16^th Edition):

Sambasivan, Ramya. “Rh(II) metallopeptides for asymmetric catalysis.” 2015. Doctoral Dissertation, Rice University. Accessed March 04, 2021. http://hdl.handle.net/1911/95526.

MLA Handbook (7^th Edition):

Sambasivan, Ramya. “Rh(II) metallopeptides for asymmetric catalysis.” 2015. Web. 04 Mar 2021.

Vancouver:

Sambasivan R. Rh(II) metallopeptides for asymmetric catalysis. [Internet] [Doctoral dissertation]. Rice University; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1911/95526.

Council of Science Editors:

Sambasivan R. Rh(II) metallopeptides for asymmetric catalysis. [Doctoral Dissertation]. Rice University; 2015. Available from: http://hdl.handle.net/1911/95526

9. Minerali, Eni. Asymmetric synthesis of enantioenriched spirocycles via a chiral Brønsted acid catalyzed desymmetrization.

Degree: 2019, NC Docks

URL: http://libres.uncg.edu/ir/uncg/f/Minerali_uncg_0154M_12848.pdf

► Asymmetric methodologies are very important as they allow chemists to produce significant quantities of complex chiral molecules as enantiopure or enantioenriched compounds. The Petersen group… (more)

Subjects/Keywords: Asymmetric synthesis; Chirality; Catalysis

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APA (6^th Edition):

Minerali, E. (2019). Asymmetric synthesis of enantioenriched spirocycles via a chiral Brønsted acid catalyzed desymmetrization. (Thesis). NC Docks. Retrieved from http://libres.uncg.edu/ir/uncg/f/Minerali_uncg_0154M_12848.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Minerali, Eni. “Asymmetric synthesis of enantioenriched spirocycles via a chiral Brønsted acid catalyzed desymmetrization.” 2019. Thesis, NC Docks. Accessed March 04, 2021. http://libres.uncg.edu/ir/uncg/f/Minerali_uncg_0154M_12848.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Minerali, Eni. “Asymmetric synthesis of enantioenriched spirocycles via a chiral Brønsted acid catalyzed desymmetrization.” 2019. Web. 04 Mar 2021.

Vancouver:

Minerali E. Asymmetric synthesis of enantioenriched spirocycles via a chiral Brønsted acid catalyzed desymmetrization. [Internet] [Thesis]. NC Docks; 2019. [cited 2021 Mar 04]. Available from: http://libres.uncg.edu/ir/uncg/f/Minerali_uncg_0154M_12848.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Minerali E. Asymmetric synthesis of enantioenriched spirocycles via a chiral Brønsted acid catalyzed desymmetrization. [Thesis]. NC Docks; 2019. Available from: http://libres.uncg.edu/ir/uncg/f/Minerali_uncg_0154M_12848.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Colorado State University

10. Vora, Harit. N-heterocyclic carbene catalyzed α-redox reaction: catalytic synthesis of amides and carboxylic acids.

Degree: PhD, Chemistry, 2011, Colorado State University

URL: http://hdl.handle.net/10217/52114

► N-heterocyclic carbene catalyzed α-redox reaction has been utilized towards the catalytic synthesis of amides utilizing amines and substoichiometric quantities of an acyl transfer reagent in… (more)

Subjects/Keywords: synthesis; NHC catalysis; organic chemistry; asymmetric; catalysis

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APA (6^th Edition):

Vora, H. (2011). N-heterocyclic carbene catalyzed α-redox reaction: catalytic synthesis of amides and carboxylic acids. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/52114

Chicago Manual of Style (16^th Edition):

Vora, Harit. “N-heterocyclic carbene catalyzed α-redox reaction: catalytic synthesis of amides and carboxylic acids.” 2011. Doctoral Dissertation, Colorado State University. Accessed March 04, 2021. http://hdl.handle.net/10217/52114.

MLA Handbook (7^th Edition):

Vora, Harit. “N-heterocyclic carbene catalyzed α-redox reaction: catalytic synthesis of amides and carboxylic acids.” 2011. Web. 04 Mar 2021.

Vancouver:

Vora H. N-heterocyclic carbene catalyzed α-redox reaction: catalytic synthesis of amides and carboxylic acids. [Internet] [Doctoral dissertation]. Colorado State University; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10217/52114.

Council of Science Editors:

Vora H. N-heterocyclic carbene catalyzed α-redox reaction: catalytic synthesis of amides and carboxylic acids. [Doctoral Dissertation]. Colorado State University; 2011. Available from: http://hdl.handle.net/10217/52114

11. Stache, Erin Elizabeth. Dual nickel- and photoredox-catalyzed enantioselective desymmetrization of meso anhydrides and C-O bond activation via phosphines and photoredox catalysis.

Degree: PhD, Chemistry, 2018, Colorado State University

URL: http://hdl.handle.net/10217/191328

► Described herein is the application of photoredox catalysis in the development of new synthetic methods. A dual nickel- and photoredox catalyzed desymmetrization of meso succinic… (more)

Subjects/Keywords: nickel catalysis; photochemistry; organic synthesis; asymmetric catalysis

10 more images…

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APA (6^th Edition):

Stache, E. E. (2018). Dual nickel- and photoredox-catalyzed enantioselective desymmetrization of meso anhydrides and C-O bond activation via phosphines and photoredox catalysis. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/191328

Chicago Manual of Style (16^th Edition):

Stache, Erin Elizabeth. “Dual nickel- and photoredox-catalyzed enantioselective desymmetrization of meso anhydrides and C-O bond activation via phosphines and photoredox catalysis.” 2018. Doctoral Dissertation, Colorado State University. Accessed March 04, 2021. http://hdl.handle.net/10217/191328.

MLA Handbook (7^th Edition):

Stache, Erin Elizabeth. “Dual nickel- and photoredox-catalyzed enantioselective desymmetrization of meso anhydrides and C-O bond activation via phosphines and photoredox catalysis.” 2018. Web. 04 Mar 2021.

Vancouver:

Stache EE. Dual nickel- and photoredox-catalyzed enantioselective desymmetrization of meso anhydrides and C-O bond activation via phosphines and photoredox catalysis. [Internet] [Doctoral dissertation]. Colorado State University; 2018. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10217/191328.

Council of Science Editors:

Stache EE. Dual nickel- and photoredox-catalyzed enantioselective desymmetrization of meso anhydrides and C-O bond activation via phosphines and photoredox catalysis. [Doctoral Dissertation]. Colorado State University; 2018. Available from: http://hdl.handle.net/10217/191328

University of St. Andrews

12. Durrani, Jamie T. Palladium catalysed asymmetric hydroxy- and alkoxycarbonylation of alkenes .

Degree: 2015, University of St. Andrews

URL: http://hdl.handle.net/10023/6276

► Palladium catalysed asymmetric hydroxy- and alkoxycarbonylation reactions of alkenes have the potential to deliver valuable chiral carboxylic acid and ester building blocks from cheap feedstocks:… (more)

Subjects/Keywords: Hydroxycarbonylation; Alkoxycarbonylation; Carbonylation; Asymmetric catalysis; Homogeneous catalysis

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APA (6^th Edition):

Durrani, J. T. (2015). Palladium catalysed asymmetric hydroxy- and alkoxycarbonylation of alkenes . (Thesis). University of St. Andrews. Retrieved from http://hdl.handle.net/10023/6276

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Durrani, Jamie T. “Palladium catalysed asymmetric hydroxy- and alkoxycarbonylation of alkenes .” 2015. Thesis, University of St. Andrews. Accessed March 04, 2021. http://hdl.handle.net/10023/6276.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Durrani, Jamie T. “Palladium catalysed asymmetric hydroxy- and alkoxycarbonylation of alkenes .” 2015. Web. 04 Mar 2021.

Vancouver:

Durrani JT. Palladium catalysed asymmetric hydroxy- and alkoxycarbonylation of alkenes . [Internet] [Thesis]. University of St. Andrews; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10023/6276.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Durrani JT. Palladium catalysed asymmetric hydroxy- and alkoxycarbonylation of alkenes . [Thesis]. University of St. Andrews; 2015. Available from: http://hdl.handle.net/10023/6276

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université Catholique de Louvain

13. Nahra, Fady. Study of new reactions catalysed by copper(I) complexes : investigation of domino catalysis- and dual catalysis-type reactions.

Degree: 2013, Université Catholique de Louvain

URL: http://hdl.handle.net/2078.1/133426

►

In this thesis we are going to first discuss the application of a copper hydride system, which was previously developed in our lab, to new… (more)

Subjects/Keywords: Asymmetric catalysis; Copper(I); Palladium(0); Domino catalysis; Dual catalysis

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APA (6^th Edition):

Nahra, F. (2013). Study of new reactions catalysed by copper(I) complexes : investigation of domino catalysis- and dual catalysis-type reactions. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/133426

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nahra, Fady. “Study of new reactions catalysed by copper(I) complexes : investigation of domino catalysis- and dual catalysis-type reactions.” 2013. Thesis, Université Catholique de Louvain. Accessed March 04, 2021. http://hdl.handle.net/2078.1/133426.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nahra, Fady. “Study of new reactions catalysed by copper(I) complexes : investigation of domino catalysis- and dual catalysis-type reactions.” 2013. Web. 04 Mar 2021.

Vancouver:

Nahra F. Study of new reactions catalysed by copper(I) complexes : investigation of domino catalysis- and dual catalysis-type reactions. [Internet] [Thesis]. Université Catholique de Louvain; 2013. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/2078.1/133426.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nahra F. Study of new reactions catalysed by copper(I) complexes : investigation of domino catalysis- and dual catalysis-type reactions. [Thesis]. Université Catholique de Louvain; 2013. Available from: http://hdl.handle.net/2078.1/133426

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of St. Andrews

14. Gilbert, Sophie Hannah. Rhodium catalysed asymmetric synthesis of tertiary amines .

Degree: 2020, University of St. Andrews

URL: http://hdl.handle.net/10023/19528

► The asymmetric synthesis of tertiary amines is a highly desirable goal, but far fewer efficient synthetic methods exist for their synthesis, relative to primary and… (more)

▼ The asymmetric synthesis of tertiary amines is a highly desirable goal, but far fewer efficient synthetic methods exist for their synthesis, relative to primary and secondary amines. A possible atom-efficient method of tertiary amine formation is catalytic hydrogenation. Despite the demand, there are only a few reported examples of asymmetric enamine hydrogenation, and none of these conditions are efficient enough to be viable for industrial processes. Until 2019, there were no reported examples of tertiary amine formation by using direct asymmetric reductive amination using H₂ as the reductant. This thesis describes the development of both enantioselective and diastereoselective reductive aminations, using hydrogen gas and homogeneous rhodium catalysts. The enantioselective reductive amination uses an electron deficient phanephos ligand and reduces bicyclic aryl ketones at low catalyst loadings but moderate selectivity. The diastereoselective reductive amination uses electron deficient monophosphines as ligands and includes many chiral 3-substituted cyclic ketones in the substrate scope, mainly 3- arylcyclohexanones. These 3-arylcyclohexanones substrates were synthesised by rhodium catalysed conjugate addition. This enantioselective conjugate addition was combined with our diastereoselective reductive amination, to form a highly stereoselective one-pot process. The rhodium used in the conjugate addition was recycled for the reductive amination step using an ‘assisted tandem catalysis’ strategy. The rhodium catalyst was modified in situ by the sequential addition of a monophosphine ligand, allowing it to catalyse the second step. This process formed a chiral tertiary amine with high selectivity and conversion. While developing this one-pot process, BOBPHOS, a phospholane-phosphite ligand, was identified as a highly active ligand in rhodium catalysed conjugate additions. The potential of BOBPHOS-Rh catalysed conjugate additions of challenging substrates like piperidones, coumarins and heteroarylboronic acids was examined, leading to improved protocols. Advisors/Committee Members: Clarke, Matt (advisor).

Subjects/Keywords: Chemistry; Catalysis; Homogeneous catalysis; Hydrogenation; Asymmetric catalysis; Chiral amines; Organometallic chemistry

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APA (6^th Edition):

Gilbert, S. H. (2020). Rhodium catalysed asymmetric synthesis of tertiary amines . (Thesis). University of St. Andrews. Retrieved from http://hdl.handle.net/10023/19528

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gilbert, Sophie Hannah. “Rhodium catalysed asymmetric synthesis of tertiary amines .” 2020. Thesis, University of St. Andrews. Accessed March 04, 2021. http://hdl.handle.net/10023/19528.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gilbert, Sophie Hannah. “Rhodium catalysed asymmetric synthesis of tertiary amines .” 2020. Web. 04 Mar 2021.

Vancouver:

Gilbert SH. Rhodium catalysed asymmetric synthesis of tertiary amines . [Internet] [Thesis]. University of St. Andrews; 2020. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10023/19528.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gilbert SH. Rhodium catalysed asymmetric synthesis of tertiary amines . [Thesis]. University of St. Andrews; 2020. Available from: http://hdl.handle.net/10023/19528

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Berkeley

15. Neel, Andrew James. Toward the Rational Design of Asymmetric Catalysts using Attractive Non-Covalent Interactions and Design Elements.

Degree: Chemistry, 2016, University of California – Berkeley

URL: http://www.escholarship.org/uc/item/34d2396n

► Throughout my doctoral studies, I have endeavored to address the question of how to rationally design chiral catalysts to control enantioselectivity in a predictable fashion.… (more)

▼ Throughout my doctoral studies, I have endeavored to address the question of how to rationally design chiral catalysts to control enantioselectivity in a predictable fashion. To approach this problem, I have focused on the strategic implementation of attractive non-covalent interactions between catalysts and their substrates at the enantiodetermining transition state. A significant portion of this work involved the development of an approach to elucidating the structural origins of selectivity in complex data sets, with an eye towards rational catalyst design. The insights gained from these studies constitute the subject matter of this dissertation.Chapter 1 provides an overview of a subset of attractive non-covalent interactions involving aromatic rings. Examples are highlighted in which these interactions have been characterized in the ground state with the explicit intention of quantifying their strengths and geometric requirements. Using the lessons learned from these reports, case studies are presented in which the interactions under discussion have been leveraged to catalyze chemical reactions via the paradigm of transition state stabilization. The insight gleaned from this literature survey is intended to provide a framework for the discussion of the catalyst design concepts outlined in the following chapters.Chapter 2 describes the development of a novel class of axially chiral triazole containing phosphoric acid catalysts designed to impart enantioselectivity via attractive non-covalent interactions with a substrate at the enantiodetermining TS. This strategy stands in contrast to that typically discussed in the literature in which catalyst steric bulk is frequently invoked to rationalize asymmetric induction. Using this newly prepared catalyst library, an enantioselective cross dehydrogenative coupling was developed within the conceptual framework of the Toste group’s strategy of chiral anion phase transfer catalysis. Preliminary experiments suggested that the triazole substituents played a role in the determination of asymmetric induction beyond steric bulk, as initially hypothesized. The third chapter describes our efforts to elucidate the structural origins of enantioselectivity in the oxidative coupling reaction presented in Chapter 2. By obtaining an enantioselectivity data set based on strategically modulated catalysts and substrates, we applied linear regression techniques to correlate our experimental data with molecular descriptors describing the structural variation throughout the data set. The resulting models, along with the overall enantioselectivity trends, were used to develop intuitively sensible mechanistic hypotheses that were subsequently tested through the application of new catalysts specifically tailored to address them. Based on the hypothesis that the triazole catalysts were engaged in enantiodetermining  interactions with the substrates at the TS, we rationally designed catalysts that afforded the products with the highest enantiomeric excesses reported to…

Subjects/Keywords: Chemistry; Asymmetric Catalysis; Organic Synthesis; Organocatalysis

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APA (6^th Edition):

Neel, A. J. (2016). Toward the Rational Design of Asymmetric Catalysts using Attractive Non-Covalent Interactions and Design Elements. (Thesis). University of California – Berkeley. Retrieved from http://www.escholarship.org/uc/item/34d2396n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Neel, Andrew James. “Toward the Rational Design of Asymmetric Catalysts using Attractive Non-Covalent Interactions and Design Elements.” 2016. Thesis, University of California – Berkeley. Accessed March 04, 2021. http://www.escholarship.org/uc/item/34d2396n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Neel, Andrew James. “Toward the Rational Design of Asymmetric Catalysts using Attractive Non-Covalent Interactions and Design Elements.” 2016. Web. 04 Mar 2021.

Vancouver:

Neel AJ. Toward the Rational Design of Asymmetric Catalysts using Attractive Non-Covalent Interactions and Design Elements. [Internet] [Thesis]. University of California – Berkeley; 2016. [cited 2021 Mar 04]. Available from: http://www.escholarship.org/uc/item/34d2396n.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Neel AJ. Toward the Rational Design of Asymmetric Catalysts using Attractive Non-Covalent Interactions and Design Elements. [Thesis]. University of California – Berkeley; 2016. Available from: http://www.escholarship.org/uc/item/34d2396n

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Mississippi State University

16. Chakraborty, Amarraj. The method development for synthesizing chiral CCC-NHC Zr pincer complexes.

Degree: MS, Chemistry, 2015, Mississippi State University

URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-08062015-162047/ ;

► There are numerous classes of N-heterocyclic carbenes (NHCs) that have been synthesized since the discovery of stable NHCs in 1988. Their application as ligands… (more)

Subjects/Keywords: synthesis; Zr chemistry; organometallic chemistry; asymmetric catalysis

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APA (6^th Edition):

Chakraborty, A. (2015). The method development for synthesizing chiral CCC-NHC Zr pincer complexes. (Masters Thesis). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-08062015-162047/ ;

Chicago Manual of Style (16^th Edition):

Chakraborty, Amarraj. “The method development for synthesizing chiral CCC-NHC Zr pincer complexes.” 2015. Masters Thesis, Mississippi State University. Accessed March 04, 2021. http://sun.library.msstate.edu/ETD-db/theses/available/etd-08062015-162047/ ;.

MLA Handbook (7^th Edition):

Chakraborty, Amarraj. “The method development for synthesizing chiral CCC-NHC Zr pincer complexes.” 2015. Web. 04 Mar 2021.

Vancouver:

Chakraborty A. The method development for synthesizing chiral CCC-NHC Zr pincer complexes. [Internet] [Masters thesis]. Mississippi State University; 2015. [cited 2021 Mar 04]. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-08062015-162047/ ;.

Council of Science Editors:

Chakraborty A. The method development for synthesizing chiral CCC-NHC Zr pincer complexes. [Masters Thesis]. Mississippi State University; 2015. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-08062015-162047/ ;

University of Alberta

17. Rauniyar, Vivek. Mechanistic Investigation, Development and Synthetic Applications of a Catalytic Enantioselective and Diastereoselective Allylboration Methodology.

Degree: PhD, Department of Chemistry, 2009, University of Alberta

URL: https://era.library.ualberta.ca/files/kw52j8708

► Over the past two decades and continuing on, carbonyl allylation chemistry has been a very useful and popular tool for the stereocontrolled formation of carbon-carbon… (more)

▼ Over the past two decades and continuing on, carbonyl allylation chemistry has been a very useful and popular tool for the stereocontrolled formation of carbon-carbon bonds in the field of organic synthesis. In the context of natural product synthesis, the efficiency and status of aldehyde allylboration method is only matched by the asymmetric and diastereoselective aldol methodology. Unfortunately, prior to the new millennium, the means to control the absolute stereoselectivity in the addition of allylic boron reagents had been restricted to stoichiometric chiral directors, appended onto the metal center. In 2002, the research groups of Hall and Miyaura reported a new Lewis acid-catalyzed allylboration reaction manifold, which raised intriguing mechanistic questions and also paved the way for a catalytic enantioselective methodology development. Chapter 2 of this thesis details mechanistic studies related to the new Lewis acid-catalyzed allylboration. In this chapter, various control experiments and kinetic studies are presented, the results of which allowed us to propose a hypothesis involving the electrophilic boronate activation as the key factor for the observed rate enhancement. Chapter 3 describes the initial phase of our research to develop a catalytic enantioselective allylboration methodology. We discovered that Brønsted acid catalysts derived from diol•SnCl4 complexes were promising catalysts for the asymmetric addition of air and moisture stable and commercially available allylic pinacol boronates. Under this 1st generation catalyst-system, the corresponding homoallylic alcohols were obtained in moderate to good enantioselectivity and excellent diastereoselectivity. The development of a novel chiral Brønsted acid catalyst for the highly enantio- and diastereoselective allylboration reaction methodology is the single most important result to come from this thesis. Chapter 4 outlines the development of the 2nd generation catalyst system. A systematic study of the diol component of the catalyst system led us to arrive at a novel diol nicknamed Vivol on behalf of my contribution. The resulting Brønsted acid derived from Vivol•SnCl4 now provided the corresponding homoallylic alcohol products in very good to excellent enantioselectivity. Preliminary mechanistic studies along with the X-ray diffraction structure of the catalyst system are also presented. Based on this information, an even better performaning diol (termed F-Vivol) was developed. This 3rd generation catalyst system derived from F-Vivol•SnCl4 complex was shown to display consistently superior reactivity and selectivity over its 2nd generation predecessor. Chapter 5 describes our efforts to expand the reagent scope of the Brønsted acid catalyzed allylboration methodology. Furthermore, this chapter also describes the successful application of the catalytic process towards the synthesis of simple and complex molecules. Accordingly, the preparation and application of the Brønsted acid-catalyzed addition of 2-bromoallyl boron pinacolate is described.…

Subjects/Keywords: Asymmetric Catalysis, Allylboration, Allylboronate, Palmerolide A

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APA (6^th Edition):

Rauniyar, V. (2009). Mechanistic Investigation, Development and Synthetic Applications of a Catalytic Enantioselective and Diastereoselective Allylboration Methodology. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/kw52j8708

Chicago Manual of Style (16^th Edition):

Rauniyar, Vivek. “Mechanistic Investigation, Development and Synthetic Applications of a Catalytic Enantioselective and Diastereoselective Allylboration Methodology.” 2009. Doctoral Dissertation, University of Alberta. Accessed March 04, 2021. https://era.library.ualberta.ca/files/kw52j8708.

MLA Handbook (7^th Edition):

Rauniyar, Vivek. “Mechanistic Investigation, Development and Synthetic Applications of a Catalytic Enantioselective and Diastereoselective Allylboration Methodology.” 2009. Web. 04 Mar 2021.

Vancouver:

Rauniyar V. Mechanistic Investigation, Development and Synthetic Applications of a Catalytic Enantioselective and Diastereoselective Allylboration Methodology. [Internet] [Doctoral dissertation]. University of Alberta; 2009. [cited 2021 Mar 04]. Available from: https://era.library.ualberta.ca/files/kw52j8708.

Council of Science Editors:

Rauniyar V. Mechanistic Investigation, Development and Synthetic Applications of a Catalytic Enantioselective and Diastereoselective Allylboration Methodology. [Doctoral Dissertation]. University of Alberta; 2009. Available from: https://era.library.ualberta.ca/files/kw52j8708

Penn State University

18. Li, Wei. Design and Synthesis of Chiral Ligands and Their Applications in Transition Metal-catalyzed Asymmetric Reactions.

Degree: 2012, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/12770

► Transition metal catalyzed reactions are among the most powerful and direct approaches for the synthesis of organic molecules. During the past several decades, phosphorous-containing ligands… (more)

▼ Transition metal catalyzed reactions are among the most powerful and direct approaches for the synthesis of organic molecules. During the past several decades, phosphorous-containing ligands have been extensively studied in transition metal -catalyzed transformations particularly asymmetric hydrogenations. Development of new chiral ligands and efficient catalyst systems for various prochiral unsaturated substrates in asymmetric hydrogenations are the focus of this dissertation. An important family of atropisomeric biaryl bisphosphine ligands, C3*-TunePhos and related bisaminophosphines have been designed and synthesized. The Ru catalysts of the highly modular C3*-TunePhos have been proved to be highly efficient (up to 99.8% ee, up to 1,000,000 TON) for practical asymmetric hydrogenations of a wide range of unfunctionalized ketones as well as α-, β- keto esters and N-2-substituted allylphthalimides. The synthetic utility of bisaminophosphine ligands was studied for rhodium-catalyzed asymmetric hydrogenations of α-dehydroamino acid esters, affording up to 98% ee’s. A new chiral tridentate NNN-type indan-Ambox ligand was designed and synthesized targeting the direct hydrogenation of unfunctionalized aryl and alkyl ketones. Successful examples of unfunctionalized ketone reduction in a enantioselective catalytic pathway display the potential of tridentate ligands in asymmetric catalysis. Another rational design and synthesis of PNP-type bulky chiral tridentate ligand was also fulfilled, yet it failed to provide superior enantioselectivity. To solve the problems of asymmetric hydrogenation of imines and heteroaromatics, a series of Ir- or Pd-based catalyst systems have been developed. Highly enantioselective and highly efficient hydrogenation of N-aryl imine, N-H imines, β-enamine esters, quinoline derivatives and unprotected indole derivatives have been successfully achieved respectively, with up to 98% ee and 10,000 TON. Catalyst systems containing strongly electron-donating and sterically hindered bisphosphine ligand have displayed significant advantages and will lead to more updated breakthroughs. Other examples of transition metal-catalyzed reactions such as Cu-catalyzed conjugate reduction of cyclic α,β-unsaturated ketones and Ru-catalyzed dynamic kinetic resolution of α-substituted cyclic ketones have also been investigated. Some preliminary results were discussed accordingly. Advisors/Committee Members: Dr Gong Chen, Dissertation Advisor/Co-Advisor, Dr Tom Mallouk, Committee Member, Alexander Thomas Radosevich, Committee Member, Dr Qing Wang, Committee Member, Dr Xumu Zhang, Special Member.

Subjects/Keywords: synthesis; chiral ligand; asymmetric catalysis; transition metal

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APA (6^th Edition):

Li, W. (2012). Design and Synthesis of Chiral Ligands and Their Applications in Transition Metal-catalyzed Asymmetric Reactions. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/12770

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Li, Wei. “Design and Synthesis of Chiral Ligands and Their Applications in Transition Metal-catalyzed Asymmetric Reactions.” 2012. Thesis, Penn State University. Accessed March 04, 2021. https://submit-etda.libraries.psu.edu/catalog/12770.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Li, Wei. “Design and Synthesis of Chiral Ligands and Their Applications in Transition Metal-catalyzed Asymmetric Reactions.” 2012. Web. 04 Mar 2021.

Vancouver:

Li W. Design and Synthesis of Chiral Ligands and Their Applications in Transition Metal-catalyzed Asymmetric Reactions. [Internet] [Thesis]. Penn State University; 2012. [cited 2021 Mar 04]. Available from: https://submit-etda.libraries.psu.edu/catalog/12770.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Li W. Design and Synthesis of Chiral Ligands and Their Applications in Transition Metal-catalyzed Asymmetric Reactions. [Thesis]. Penn State University; 2012. Available from: https://submit-etda.libraries.psu.edu/catalog/12770

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Wayne State University

19. Averill, Derek James. Lanthanide-Based Precatalysts For Carbon-Carbon Bond-Forming Reactions In Aqueous Media.

Degree: PhD, Chemistry, 2014, Wayne State University

URL: https://digitalcommons.wayne.edu/oa_dissertations/1084

► The formation of carbon-carbon bonds is of great interest to synthetic chemists because these bonds make up the majority of biologically active compounds. The… (more)

▼ The formation of carbon-carbon bonds is of great interest to synthetic chemists because these bonds make up the majority of biologically active compounds. The Mukaiyama aldol reaction is a Lewis-acid-catalyzed carbon-carbon bond-forming reaction that has the ability to produce optically active β-hydroxy carbonyls which can be found in many pharmaceuticals and natural products. Because of precatalyst instability towards hydrolysis, anhydrous solvents are commonly used. Recent efforts have focused on water-tolerant versions of enantioselective Mukaiyama aldol reactions because of the financial and environmental benefits of using aqueous media. Consequently, the Lewis-acidic and water-tolerant features of Ln³⁺ ions have aroused great interest in lanthanide-catalyzed bond-forming reactions in aqueous media. Several Ln³⁺-based Lewis acid precatalysts that were designed for Mukaiyama aldol reactions have been shown to be enantioselective, water-tolerant, and recoverable. Limiting the usefulness of these precatalysts are high ligand loadings and long reaction times that are necessary for high enantiomeric ratios. An understanding of water-coordination number, counter anion identitiy, solvent system, and ligand type effect(s) are necessary to improve upon existing Ln³⁺-based precatalysts. I used luminescence-decay measurements and high performance liquid chromatography analyses to study the effects of water-coordination number, counter anion identitiy, and solvent system on reaction rates of Mukaiyama aldol reactions. I found that higher water-coordination numbers and higher water compositions gave rise to more reactive precatalysts for Mukaiyama aldol reactions that were catalyzed by Eu³⁺. I synthesized and characterized four new hexadentate ligands to study the effects of ligand type on reactivity and selectivity of Eu³⁺-based precatalysts for Mukaiyama aldol reactions. I used Eu³⁺ emission spectra and ¹H-NMR experiments to study changes in Eu³⁺ coordination while titrating hexadentate ligands into solutions of Eu³⁺ and I found that Eu³⁺ is able to be coordinatively saturated in the presence of excess hexadentate ligands. By studying Eu³⁺ in the presence of different anions and several chiral hexadentate ligands that contain ester, carboxylic acid, alcohol and amide donating groups I was able to find trends in reactivity and selectivity. In this thesis I describe the results that are likely to contribute to the development of highly reactive and selective Ln³⁺-based precatalysts. Advisors/Committee Members: Matthew J. Allen.

Subjects/Keywords: Aqueous; Asymmetric; Catalysis; Europium; Lanthanide; Mukaiyama; Chemistry

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APA (6^th Edition):

Averill, D. J. (2014). Lanthanide-Based Precatalysts For Carbon-Carbon Bond-Forming Reactions In Aqueous Media. (Doctoral Dissertation). Wayne State University. Retrieved from https://digitalcommons.wayne.edu/oa_dissertations/1084

Chicago Manual of Style (16^th Edition):

Averill, Derek James. “Lanthanide-Based Precatalysts For Carbon-Carbon Bond-Forming Reactions In Aqueous Media.” 2014. Doctoral Dissertation, Wayne State University. Accessed March 04, 2021. https://digitalcommons.wayne.edu/oa_dissertations/1084.

MLA Handbook (7^th Edition):

Averill, Derek James. “Lanthanide-Based Precatalysts For Carbon-Carbon Bond-Forming Reactions In Aqueous Media.” 2014. Web. 04 Mar 2021.

Vancouver:

Averill DJ. Lanthanide-Based Precatalysts For Carbon-Carbon Bond-Forming Reactions In Aqueous Media. [Internet] [Doctoral dissertation]. Wayne State University; 2014. [cited 2021 Mar 04]. Available from: https://digitalcommons.wayne.edu/oa_dissertations/1084.

Council of Science Editors:

Averill DJ. Lanthanide-Based Precatalysts For Carbon-Carbon Bond-Forming Reactions In Aqueous Media. [Doctoral Dissertation]. Wayne State University; 2014. Available from: https://digitalcommons.wayne.edu/oa_dissertations/1084

Universidade Nova

20. Zalewska, Karolina Anna Maria. Development of novel ionic liquids based on biological molecules.

Degree: 2015, Universidade Nova

URL: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/14075

► Ionic Liquids (ILs) belong to a class of compounds with unusual properties: very low vapour pressure; high chemical and thermal stability and the ability to… (more)

▼ Ionic Liquids (ILs) belong to a class of compounds with unusual properties: very low vapour pressure; high chemical and thermal stability and the ability to dissolve a wide range of substances. A new field in research is evaluating the possibility to use natural chiral biomolecules for the preparation of chiral ionic liquids (CILs). This important challenge in synthetic chemistry can open new avenues of research in order to avoid some problems related with the intrinsic biodegradability and toxicity associated to conventional ILs. The research work developed aimed for the synthesis of CILs, their characterization and possible applications, based on biological moieties used either as chiral cations or anions, depending on the synthetic manipulation of the derivatives. Overall, a total of 28 organic salts, including CILs were synthesized: 9 based on L-cysteine derivatives, 12 based on L-proline, 3 based on nucleosides and 4 based on nucleotides. All these new CILs were completely characterized and their chemical and physical properties were evaluated. Some CILs based on L-cysteine have been applied for discrimination processes, including resolution of racemates and as a chiral catalyst for asymmetric Aldol condensation. L-proline derived CILs were also studied as chiral catalysts for Michael reaction. In parallel, the interactions of macrocyclic oligosugars called cyclodextrins (CDs) with several ILs were studied. It was possible to improve the solubility of CDs in water and serum. Additionally, fatty acids and steroids showed an increase in water solubility when ILs-CDs systems were used. The development of efficient and selective ILs-CDs systems is indispensable to expand the range of their applications in host-guest interactions, drug delivery systems or catalytic reactions. Novel salts derived from nucleobases were used in order to enhance the fluorescence in aqueous solution. Additionally, preliminary studies regarding ethyl lactate as an alternative solvent for asymmetric organocatalysis were performed. Advisors/Committee Members: Branco, Luís.

Subjects/Keywords: Ionic liquids; Biological molecules; Chirality; Asymmetric catalysis

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APA (6^th Edition):

Zalewska, K. A. M. (2015). Development of novel ionic liquids based on biological molecules. (Thesis). Universidade Nova. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/14075

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zalewska, Karolina Anna Maria. “Development of novel ionic liquids based on biological molecules.” 2015. Thesis, Universidade Nova. Accessed March 04, 2021. http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/14075.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zalewska, Karolina Anna Maria. “Development of novel ionic liquids based on biological molecules.” 2015. Web. 04 Mar 2021.

Vancouver:

Zalewska KAM. Development of novel ionic liquids based on biological molecules. [Internet] [Thesis]. Universidade Nova; 2015. [cited 2021 Mar 04]. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/14075.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zalewska KAM. Development of novel ionic liquids based on biological molecules. [Thesis]. Universidade Nova; 2015. Available from: http://www.rcaap.pt/detail.jsp?id=oai:run.unl.pt:10362/14075

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Colorado State University

21. Glover, Garrett S. Development of an asymmetric intermolecular stetter reaction and organocatalyst design.

Degree: MS(M.S.), Chemistry, 2012, Colorado State University

URL: http://hdl.handle.net/10217/88358

► The intermolecular Stetter represents a powerful carbon-carbon bond forming reaction that involves addition of an acyl anion equivalent to an untethered Michael acceptor. Despite the… (more)

Subjects/Keywords: asymmetric catalysis; Stetter reaction; organocatalysis; NHC; intermolecular

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APA (6^th Edition):

Glover, G. S. (2012). Development of an asymmetric intermolecular stetter reaction and organocatalyst design. (Masters Thesis). Colorado State University. Retrieved from http://hdl.handle.net/10217/88358

Chicago Manual of Style (16^th Edition):

Glover, Garrett S. “Development of an asymmetric intermolecular stetter reaction and organocatalyst design.” 2012. Masters Thesis, Colorado State University. Accessed March 04, 2021. http://hdl.handle.net/10217/88358.

MLA Handbook (7^th Edition):

Glover, Garrett S. “Development of an asymmetric intermolecular stetter reaction and organocatalyst design.” 2012. Web. 04 Mar 2021.

Vancouver:

Glover GS. Development of an asymmetric intermolecular stetter reaction and organocatalyst design. [Internet] [Masters thesis]. Colorado State University; 2012. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10217/88358.

Council of Science Editors:

Glover GS. Development of an asymmetric intermolecular stetter reaction and organocatalyst design. [Masters Thesis]. Colorado State University; 2012. Available from: http://hdl.handle.net/10217/88358

Colorado State University

22. Filloux, Claire M. Organocatalytic, Michael-Stetter reaction and rhodium(I)-catalyzed hydroheteroarylation of acrylates with benzoxazoles: reaction development and investigations into origins of enantioselectivity.

Degree: PhD, Chemistry, 2015, Colorado State University

URL: http://hdl.handle.net/10217/166906

► The chapters that follow describe two independent investigations. Both relay the development of experimental methods for the catalytic, asymmetric addition of carbon-hydrogen bonds to alkenes.… (more)

Subjects/Keywords: catalysis; organic; asymmetric; rhodium; N-heterocyclic carbene

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APA (6^th Edition):

Filloux, C. M. (2015). Organocatalytic, Michael-Stetter reaction and rhodium(I)-catalyzed hydroheteroarylation of acrylates with benzoxazoles: reaction development and investigations into origins of enantioselectivity. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/166906

Chicago Manual of Style (16^th Edition):

Filloux, Claire M. “Organocatalytic, Michael-Stetter reaction and rhodium(I)-catalyzed hydroheteroarylation of acrylates with benzoxazoles: reaction development and investigations into origins of enantioselectivity.” 2015. Doctoral Dissertation, Colorado State University. Accessed March 04, 2021. http://hdl.handle.net/10217/166906.

MLA Handbook (7^th Edition):

Filloux, Claire M. “Organocatalytic, Michael-Stetter reaction and rhodium(I)-catalyzed hydroheteroarylation of acrylates with benzoxazoles: reaction development and investigations into origins of enantioselectivity.” 2015. Web. 04 Mar 2021.

Vancouver:

Filloux CM. Organocatalytic, Michael-Stetter reaction and rhodium(I)-catalyzed hydroheteroarylation of acrylates with benzoxazoles: reaction development and investigations into origins of enantioselectivity. [Internet] [Doctoral dissertation]. Colorado State University; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10217/166906.

Council of Science Editors:

Filloux CM. Organocatalytic, Michael-Stetter reaction and rhodium(I)-catalyzed hydroheteroarylation of acrylates with benzoxazoles: reaction development and investigations into origins of enantioselectivity. [Doctoral Dissertation]. Colorado State University; 2015. Available from: http://hdl.handle.net/10217/166906

Boston College

23. Coombs, John Ryan. Platinum-Catalyzed Enantioselective Diboration of Terminal Alkenes and Vinyl Boronates: Construction of Multiborylated Compounds for Asymmetric Synthesis.

Degree: PhD, Chemistry, 2015, Boston College

URL: http://dlib.bc.edu/islandora/object/bc-ir:104624

► This dissertation will discuss in depth four main projects pertaining to the synthesis and utility of organoboronates for the construction of enantioenriched small molecules. First,… (more)

Subjects/Keywords: Asymmetric Catalysis; Boron-Wittig Reaction; Diboration

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APA (6^th Edition):

Coombs, J. R. (2015). Platinum-Catalyzed Enantioselective Diboration of Terminal Alkenes and Vinyl Boronates: Construction of Multiborylated Compounds for Asymmetric Synthesis. (Doctoral Dissertation). Boston College. Retrieved from http://dlib.bc.edu/islandora/object/bc-ir:104624

Chicago Manual of Style (16^th Edition):

Coombs, John Ryan. “Platinum-Catalyzed Enantioselective Diboration of Terminal Alkenes and Vinyl Boronates: Construction of Multiborylated Compounds for Asymmetric Synthesis.” 2015. Doctoral Dissertation, Boston College. Accessed March 04, 2021. http://dlib.bc.edu/islandora/object/bc-ir:104624.

MLA Handbook (7^th Edition):

Coombs, John Ryan. “Platinum-Catalyzed Enantioselective Diboration of Terminal Alkenes and Vinyl Boronates: Construction of Multiborylated Compounds for Asymmetric Synthesis.” 2015. Web. 04 Mar 2021.

Vancouver:

Coombs JR. Platinum-Catalyzed Enantioselective Diboration of Terminal Alkenes and Vinyl Boronates: Construction of Multiborylated Compounds for Asymmetric Synthesis. [Internet] [Doctoral dissertation]. Boston College; 2015. [cited 2021 Mar 04]. Available from: http://dlib.bc.edu/islandora/object/bc-ir:104624.

Council of Science Editors:

Coombs JR. Platinum-Catalyzed Enantioselective Diboration of Terminal Alkenes and Vinyl Boronates: Construction of Multiborylated Compounds for Asymmetric Synthesis. [Doctoral Dissertation]. Boston College; 2015. Available from: http://dlib.bc.edu/islandora/object/bc-ir:104624

Universitat Rovira i Virgili

24. Alza Barrios, Esther. Approaches to asymmetric catalysis with polymer-supported pyrrolidines.

Degree: Departament de Química Analítica i Química Orgànica, 2011, Universitat Rovira i Virgili

URL: http://hdl.handle.net/10803/37362

► The present research project developed is focused in the immobilization of catalytic systems allowing the formation of carbon-carbon and carbonheteroatom bonds through enantioselective procedures with… (more)

▼ The present research project developed is focused in the immobilization of catalytic systems allowing the formation of carbon-carbon and carbonheteroatom bonds through enantioselective procedures with improved sustainability characteristics (suppression of catalyst separation steps, preferential use of water as a solvent under aerobic conditions, avoidance of protecting groups and, hence, of protection and deprotection steps). In particular, the study is directed towards the organocatalysis field, although also asymmetric catalytic processes mediated by metal complexes have been developed. The approach introduced by our group combines the optimization of the catalytic properties of the ligands, which is greatly facilitated by their modular nature, with a design principle consisting in performing the anchoring to the polymer through auxiliary functional groups, positioned on the ligand molecule for minimal perturbation of the catalytic site. In this manner, we have been able to develop polymersupported ligands that do not show any decrease in catalytic activity or in enantioselectivity with respect to their homogeneous counterparts. The usual anchoring strategy used is the Cu-catalyzed azide/alkyne 1,3 dipolar cycloaddition. In this manner, in this work proline and pyrrolidine derivatives have been synthesized to catalyze organic transformations via enamine and iminium ion mechanisms as Mannich or Michael reactions. Organocatalytic cascade process has also been reported as useful method for the preparation of highly functionalized cyclohexane derivatives in a straightforward and efficient manner and the use of supported organocatalysts has allowed us to implement this reactions not only in batch processes but also in continuous flow conditions obtaining large amount of desired product with high enantiopurity. As have been mentioned, asymmetric catalysis mediated by metal complexes has been investigated. One project collect the study of the asymmetric reduction of ketones with borane and oxazaborolidine type catalysts as aminoalcohols in homogeneous phase and the application of diphenylprolinol derivatives supported on polymers by click-chemistry or by direct nucleophilic substitution to the Merrifield resin. It is verified experimentally that the triazole ring formed by anchoring the monomer to the polymer matrix by click reaction has an important role in the selectivity of the catalyst because leads to a not enantioselective path due to the boron coordination to the triazole. When triazole ring is not present, aromatic ketones are reduced with high enantioselectivities (90-99%) and complete conversion after 30 minutes of reaction with qualitative yield because the easy removing of the catalyst from the product by filtration. Also a series of new modular Ru/aminoalcohol systems has been developed and used as enantioselective catalysts in the asymmetric transfer hydrogenation reaction of ketones in both water and 2-propanol. The catalytic behaviour exhibited in these two media… Advisors/Committee Members: [email protected] (authoremail), false (authoremailshow), Pericàs i Brondo, Miquel A. (Miquel Àngel) (director), Sayalero, Sonia (codirector), true (authorsendemail).

Subjects/Keywords: Asymmetric catalysis; Organocatalysis; Supported catalysts; 54; 547

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APA (6^th Edition):

Alza Barrios, E. (2011). Approaches to asymmetric catalysis with polymer-supported pyrrolidines. (Thesis). Universitat Rovira i Virgili. Retrieved from http://hdl.handle.net/10803/37362

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alza Barrios, Esther. “Approaches to asymmetric catalysis with polymer-supported pyrrolidines.” 2011. Thesis, Universitat Rovira i Virgili. Accessed March 04, 2021. http://hdl.handle.net/10803/37362.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alza Barrios, Esther. “Approaches to asymmetric catalysis with polymer-supported pyrrolidines.” 2011. Web. 04 Mar 2021.

Vancouver:

Alza Barrios E. Approaches to asymmetric catalysis with polymer-supported pyrrolidines. [Internet] [Thesis]. Universitat Rovira i Virgili; 2011. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10803/37362.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alza Barrios E. Approaches to asymmetric catalysis with polymer-supported pyrrolidines. [Thesis]. Universitat Rovira i Virgili; 2011. Available from: http://hdl.handle.net/10803/37362

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

National University of Ireland – Galway

25. Mc Cleary, Nadine. Design, synthesis and catalytic activity of novel oxazoline based ligands .

Degree: 2015, National University of Ireland – Galway

URL: http://hdl.handle.net/10379/5210

► This thesis can be viewed as two separate studies. Firstly, the design, synthesis and catalytic activity of novel 2-pyridyl mono(oxazoline). A family of mono(oxazoline) ligands… (more)

Subjects/Keywords: Asymmetric catalysis; Organic synthesis; School of Chemistry

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APA (6^th Edition):

Mc Cleary, N. (2015). Design, synthesis and catalytic activity of novel oxazoline based ligands . (Thesis). National University of Ireland – Galway. Retrieved from http://hdl.handle.net/10379/5210

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mc Cleary, Nadine. “Design, synthesis and catalytic activity of novel oxazoline based ligands .” 2015. Thesis, National University of Ireland – Galway. Accessed March 04, 2021. http://hdl.handle.net/10379/5210.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mc Cleary, Nadine. “Design, synthesis and catalytic activity of novel oxazoline based ligands .” 2015. Web. 04 Mar 2021.

Vancouver:

Mc Cleary N. Design, synthesis and catalytic activity of novel oxazoline based ligands . [Internet] [Thesis]. National University of Ireland – Galway; 2015. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10379/5210.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mc Cleary N. Design, synthesis and catalytic activity of novel oxazoline based ligands . [Thesis]. National University of Ireland – Galway; 2015. Available from: http://hdl.handle.net/10379/5210

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

National University of Ireland – Galway

26. Kellehan, David. Synthesis and Application of Chiral AraBOX ligands for Asymmetric Catalysis .

Degree: 2012, National University of Ireland – Galway

URL: http://hdl.handle.net/10379/3405

► This thesis deals with the design, synthesis and reactivity of novel 4,4'-bisoxazoline ligands and their metal complexes; (S,S)-MePrAraBOX, (S,S)-PhPrAraBOX, (S,R)-MePrAraBOX, (S,R)-PhPrAraBOX, (S,R)-BnOAcAraBOX and (S,R)-BnOHAraBOX. Metal… (more)

▼ This thesis deals with the design, synthesis and reactivity of novel 4,4'-bisoxazoline ligands and their metal complexes; (S,S)-MePrAraBOX, (S,S)-PhPrAraBOX, (S,R)-MePrAraBOX, (S,R)-PhPrAraBOX, (S,R)-BnOAcAraBOX and (S,R)-BnOHAraBOX. Metal complexes of these ligands have been applied to transition metal catalysed asymmetric reactions, in particular asymmetric Diels Alder, cyclopropanation and allylic alkylation reactions. A copper(II) complex of (S,R)-PhPrAraBOX catalysed a benchmark Diels Alder reaction in up to 57% ee, the highest enantioselectivity yet achieved for a 4,4'-BOX ligand in a Diels Alder reaction. An ee of 70% was achieved with a copper(I) complex of (S,S)-MePrAraBOX in a benchmark asymmetric cyclopropanation reaction, which is also the highest enantioselectivity yet achieved for a 4,4'-BOX ligand in these reactions. The ligands were also applied to the asymmetric allylic alkylation reaction. They were the first 4,4'-BOX ligands to generate enantiocontrol in the reaction, with a palladium complex of (S,S)-MePrAraBOX producing an ee of 72%. The rationalisation of these results, in particular the results relating to the cyclopropanation reaction, are supported by computational studies carried out by colleagues in Zaragoza. The 4,4'-bisoxazoline ligands (S,R)-BnOAcAraBOX and (S,R)-BnOHAraBOX, which contain secondary binding sites, were applied to the Diels Alder and asymmetric allylic alkylation reactions with low activity and selectivity. Ligand (S,R)-BnOHAraBOX was also applied to an asymmetric alkylation of benzaldehyde, showing low conversion and no selectivity. Chapter One deals with the introduction of the general concepts of asymmetric synthesis and asymmetric catalysis. Chapter Two discusses the synthesis of the 4,4'-bisoxazoline ligands and the application of the metal complexes of these ligands to the asymmetric reactions. Chapter Three contains the full experimental details for the project, including spectral and analytical data. Advisors/Committee Members: O'Leary, Patrick (advisor).

Subjects/Keywords: Bisoxazoline ligands; Asymmetric catalysis; Department of Chemistry

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APA (6^th Edition):

Kellehan, D. (2012). Synthesis and Application of Chiral AraBOX ligands for Asymmetric Catalysis . (Thesis). National University of Ireland – Galway. Retrieved from http://hdl.handle.net/10379/3405

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kellehan, David. “Synthesis and Application of Chiral AraBOX ligands for Asymmetric Catalysis .” 2012. Thesis, National University of Ireland – Galway. Accessed March 04, 2021. http://hdl.handle.net/10379/3405.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kellehan, David. “Synthesis and Application of Chiral AraBOX ligands for Asymmetric Catalysis .” 2012. Web. 04 Mar 2021.

Vancouver:

Kellehan D. Synthesis and Application of Chiral AraBOX ligands for Asymmetric Catalysis . [Internet] [Thesis]. National University of Ireland – Galway; 2012. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/10379/3405.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kellehan D. Synthesis and Application of Chiral AraBOX ligands for Asymmetric Catalysis . [Thesis]. National University of Ireland – Galway; 2012. Available from: http://hdl.handle.net/10379/3405

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

27. Smith, Samantha Alizabeth Michelle. Asymmetric Hydrogenation Using Catalysts Based on Abundant Metals.

Degree: PhD, 2018, University of Toronto

URL: http://hdl.handle.net/1807/89841

► The design of chiral catalysts for hydrogenation chemistry is a field forever continuing as there are always improvements to be made, either in activity, selectivity,… (more)

▼ The design of chiral catalysts for hydrogenation chemistry is a field forever continuing as there are always improvements to be made, either in activity, selectivity, or cost and toxicity of catalysts. This dissertation focuses on the design and synthesis of new base-metal catalysts with the intention to improve the activity and selectivity of asymmetric hydrogenation reactions. This was approached with the following goals in mind: the improvement of syntheses of current catalysts to reduce the cost or to decrease the harshness of catalytic conditions required, the variation of phosphine donors for insight into the mechanism and to use such data to assist in the future rational design of new catalysts, and the use of other less-used abundant first row transition metals to explore the limits of such metals in hydrogenation chemistry. Each of the chapters discussed, with the exception of Chapter 1, describes the findings of new catalysts which were synthesized following one or more of the goals outlined and how they differ from previously reported related complexes, both fundamentally in their molecular structures as well as their activity and selectivity in the asymmetric hydrogenation of ketones. New asymmetric transfer hydrogenation catalysts were synthesized following our previous reports with a series of phosphorus donors. This resulted in an increase in enantioselectivity of the product alcohols at the cost of lower activity. An improvement of synthesis and variation of donors for pincer iron catalysts applied in the asymmetric pressure hydrogenation of ketones resulted in an increase in enantioselectivity; however slightly higher pressures of H2 gas were required for complete conversion (10 vs 5 bar). Manganese analogues of the previously mentioned pincer complexes were discovered to be active in the asymmetric pressure hydrogenation of ketones. These complexes required higher pressures and temperatures than their iron counterparts, but we did see an improvement of catalytic results when comparing to other manganese hydrogenation catalysts recently reported since our catalysts operate at lower temperatures, pressures, and shorter reaction times. An iron complex bearing a new chiral, bidentate, and protic NHC-PPh2 ligand was synthesized for the asymmetric transfer hydrogenation of acetophenone. This complex requires UV-irradiation for catalysis. Advisors/Committee Members: Morris, Robert H, Chemistry.

Subjects/Keywords: abundant metals; asymmetric; catalysis; hydrogenation; 0488

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APA (6^th Edition):

Smith, S. A. M. (2018). Asymmetric Hydrogenation Using Catalysts Based on Abundant Metals. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/89841

Chicago Manual of Style (16^th Edition):

Smith, Samantha Alizabeth Michelle. “Asymmetric Hydrogenation Using Catalysts Based on Abundant Metals.” 2018. Doctoral Dissertation, University of Toronto. Accessed March 04, 2021. http://hdl.handle.net/1807/89841.

MLA Handbook (7^th Edition):

Smith, Samantha Alizabeth Michelle. “Asymmetric Hydrogenation Using Catalysts Based on Abundant Metals.” 2018. Web. 04 Mar 2021.

Vancouver:

Smith SAM. Asymmetric Hydrogenation Using Catalysts Based on Abundant Metals. [Internet] [Doctoral dissertation]. University of Toronto; 2018. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1807/89841.

Council of Science Editors:

Smith SAM. Asymmetric Hydrogenation Using Catalysts Based on Abundant Metals. [Doctoral Dissertation]. University of Toronto; 2018. Available from: http://hdl.handle.net/1807/89841

University of Toronto

28. Kim, Byoungmoo. Asymmetric Lactone Synthesis via Hydroacylation and Stereoselective Cyclic Peptide Synthesis via Hydrogenation.

Degree: PhD, 2014, University of Toronto

URL: http://hdl.handle.net/1807/71059

►

Asymmetric transition metal catalysis has benefited human health by greatly facilitating access to natural products and therapeutic drugs. However, scientists continue to face challenges of… (more)

Subjects/Keywords: Asymmetric catalysis; Cyclic peptide; Lactone; Rhoidum; 0485

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APA (6^th Edition):

Kim, B. (2014). Asymmetric Lactone Synthesis via Hydroacylation and Stereoselective Cyclic Peptide Synthesis via Hydrogenation. (Doctoral Dissertation). University of Toronto. Retrieved from http://hdl.handle.net/1807/71059

Chicago Manual of Style (16^th Edition):

Kim, Byoungmoo. “Asymmetric Lactone Synthesis via Hydroacylation and Stereoselective Cyclic Peptide Synthesis via Hydrogenation.” 2014. Doctoral Dissertation, University of Toronto. Accessed March 04, 2021. http://hdl.handle.net/1807/71059.

MLA Handbook (7^th Edition):

Kim, Byoungmoo. “Asymmetric Lactone Synthesis via Hydroacylation and Stereoselective Cyclic Peptide Synthesis via Hydrogenation.” 2014. Web. 04 Mar 2021.

Vancouver:

Kim B. Asymmetric Lactone Synthesis via Hydroacylation and Stereoselective Cyclic Peptide Synthesis via Hydrogenation. [Internet] [Doctoral dissertation]. University of Toronto; 2014. [cited 2021 Mar 04]. Available from: http://hdl.handle.net/1807/71059.

Council of Science Editors:

Kim B. Asymmetric Lactone Synthesis via Hydroacylation and Stereoselective Cyclic Peptide Synthesis via Hydrogenation. [Doctoral Dissertation]. University of Toronto; 2014. Available from: http://hdl.handle.net/1807/71059

University of New Mexico

29. Song, Xixi. Development of novel organocatalytic cascade reactions and application in organic systheses.

Degree: Department of Chemistry and Chemical Biology, 2012, University of New Mexico

URL: https://digitalrepository.unm.edu/chem_etds/24

► The development of new catalytic reactions, particularly synthetically efficient cascade processes for the facile preparation of important molecular architectures, which otherwise are difficult to access… (more)

Subjects/Keywords: organocatalysis; cascade reaction; asymmetric catalysis; aminocatalysis

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APA (6^th Edition):

Song, X. (2012). Development of novel organocatalytic cascade reactions and application in organic systheses. (Doctoral Dissertation). University of New Mexico. Retrieved from https://digitalrepository.unm.edu/chem_etds/24

Chicago Manual of Style (16^th Edition):

Song, Xixi. “Development of novel organocatalytic cascade reactions and application in organic systheses.” 2012. Doctoral Dissertation, University of New Mexico. Accessed March 04, 2021. https://digitalrepository.unm.edu/chem_etds/24.

MLA Handbook (7^th Edition):

Song, Xixi. “Development of novel organocatalytic cascade reactions and application in organic systheses.” 2012. Web. 04 Mar 2021.

Vancouver:

Song X. Development of novel organocatalytic cascade reactions and application in organic systheses. [Internet] [Doctoral dissertation]. University of New Mexico; 2012. [cited 2021 Mar 04]. Available from: https://digitalrepository.unm.edu/chem_etds/24.

Council of Science Editors:

Song X. Development of novel organocatalytic cascade reactions and application in organic systheses. [Doctoral Dissertation]. University of New Mexico; 2012. Available from: https://digitalrepository.unm.edu/chem_etds/24

University of South Florida

30. Tao, Jingran. Asymmetric Nitrene Transfer Reactions with Azides via Co(II)-Based Metalloradical Catalysis (MRC).

Degree: 2013, University of South Florida

URL: https://scholarcommons.usf.edu/etd/4590

► Asymmetric nitrene transfer reactions via metalloradical catalysis (MRC) with azides has attracted research interest because of its fundamental and practical importance. The resulting nitrogen-containing units… (more)

Subjects/Keywords: asymmetric; azide; aziridination; catalysis; cobalt; porphyrin; Chemistry

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APA (6^th Edition):

Tao, J. (2013). Asymmetric Nitrene Transfer Reactions with Azides via Co(II)-Based Metalloradical Catalysis (MRC). (Thesis). University of South Florida. Retrieved from https://scholarcommons.usf.edu/etd/4590

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tao, Jingran. “Asymmetric Nitrene Transfer Reactions with Azides via Co(II)-Based Metalloradical Catalysis (MRC).” 2013. Thesis, University of South Florida. Accessed March 04, 2021. https://scholarcommons.usf.edu/etd/4590.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tao, Jingran. “Asymmetric Nitrene Transfer Reactions with Azides via Co(II)-Based Metalloradical Catalysis (MRC).” 2013. Web. 04 Mar 2021.

Vancouver:

Tao J. Asymmetric Nitrene Transfer Reactions with Azides via Co(II)-Based Metalloradical Catalysis (MRC). [Internet] [Thesis]. University of South Florida; 2013. [cited 2021 Mar 04]. Available from: https://scholarcommons.usf.edu/etd/4590.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tao J. Asymmetric Nitrene Transfer Reactions with Azides via Co(II)-Based Metalloradical Catalysis (MRC). [Thesis]. University of South Florida; 2013. Available from: https://scholarcommons.usf.edu/etd/4590

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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