subject:(Arachidonic acid)

NSYSU

1. Wu, Shih-Ting. Effects of dietary arachidonic acid on growth performance and immune responses of juvenile grouper, Epinephelus coioides.

Degree: Master, Marine Biology, 2011, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0907111-144944

► This research studied the dietary effect of arachidonic acid (ARA) on growth performance and immune responses in juvenile grouper (Epinephelus coioides). The test diets used… (more)

Subjects/Keywords: grouper; arachidonic acid

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APA (6^th Edition):

Wu, S. (2011). Effects of dietary arachidonic acid on growth performance and immune responses of juvenile grouper, Epinephelus coioides. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0907111-144944

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wu, Shih-Ting. “Effects of dietary arachidonic acid on growth performance and immune responses of juvenile grouper, Epinephelus coioides.” 2011. Thesis, NSYSU. Accessed January 23, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0907111-144944.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wu, Shih-Ting. “Effects of dietary arachidonic acid on growth performance and immune responses of juvenile grouper, Epinephelus coioides.” 2011. Web. 23 Jan 2021.

Vancouver:

Wu S. Effects of dietary arachidonic acid on growth performance and immune responses of juvenile grouper, Epinephelus coioides. [Internet] [Thesis]. NSYSU; 2011. [cited 2021 Jan 23]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0907111-144944.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wu S. Effects of dietary arachidonic acid on growth performance and immune responses of juvenile grouper, Epinephelus coioides. [Thesis]. NSYSU; 2011. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0907111-144944

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Alberta

2. Alsaad,Abdulaziz M. Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity.

Degree: MS, Faculty of Pharmacy and Pharmaceutical Sciences, 2012, University of Alberta

URL: https://era.library.ualberta.ca/files/n870zs18z

► Drug-induced cardiotoxicity is classified as a predisposing factor leading to cardiac hypertrophy and heart failure. Of importance, doxorubicin (DOX, adriamycin) is considered as an effective… (more)

Subjects/Keywords: Arachidonic acid; cardiac hypertrophy; cardiotoxicity

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APA (6^th Edition):

M, A. (2012). Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/n870zs18z

Chicago Manual of Style (16^th Edition):

M, Alsaad,Abdulaziz. “Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity.” 2012. Masters Thesis, University of Alberta. Accessed January 23, 2021. https://era.library.ualberta.ca/files/n870zs18z.

MLA Handbook (7^th Edition):

M, Alsaad,Abdulaziz. “Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity.” 2012. Web. 23 Jan 2021.

Vancouver:

M A. Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity. [Internet] [Masters thesis]. University of Alberta; 2012. [cited 2021 Jan 23]. Available from: https://era.library.ualberta.ca/files/n870zs18z.

Council of Science Editors:

M A. Role of CYP-mediated Arachidonic Acid Metabolites in Development of Cardiac Hypertrophy and Chronic Doxorubicin-induced Cardiotoxicity. [Masters Thesis]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/n870zs18z

Vanderbilt University

3. Benoy, Jennifer Rae. TOTAL SYNTHESIS AND BIOLOGICAL SIGNIFICANCE OF PROSTAGLANDIN D2 AND E2 METABOLITES.

Degree: PhD, Chemistry, 2019, Vanderbilt University

URL: http://hdl.handle.net/1803/12544

► I. Prostaglandin E2 (PGE2) is a cyclic, oxygenated metabolite of arachidonic acid that has been shown to play a role in the pathophysiology of many… (more)

Subjects/Keywords: arachidonic acid; organic synthesis

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APA (6^th Edition):

Benoy, J. R. (2019). TOTAL SYNTHESIS AND BIOLOGICAL SIGNIFICANCE OF PROSTAGLANDIN D2 AND E2 METABOLITES. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/12544

Chicago Manual of Style (16^th Edition):

Benoy, Jennifer Rae. “TOTAL SYNTHESIS AND BIOLOGICAL SIGNIFICANCE OF PROSTAGLANDIN D2 AND E2 METABOLITES.” 2019. Doctoral Dissertation, Vanderbilt University. Accessed January 23, 2021. http://hdl.handle.net/1803/12544.

MLA Handbook (7^th Edition):

Benoy, Jennifer Rae. “TOTAL SYNTHESIS AND BIOLOGICAL SIGNIFICANCE OF PROSTAGLANDIN D2 AND E2 METABOLITES.” 2019. Web. 23 Jan 2021.

Vancouver:

Benoy JR. TOTAL SYNTHESIS AND BIOLOGICAL SIGNIFICANCE OF PROSTAGLANDIN D2 AND E2 METABOLITES. [Internet] [Doctoral dissertation]. Vanderbilt University; 2019. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1803/12544.

Council of Science Editors:

Benoy JR. TOTAL SYNTHESIS AND BIOLOGICAL SIGNIFICANCE OF PROSTAGLANDIN D2 AND E2 METABOLITES. [Doctoral Dissertation]. Vanderbilt University; 2019. Available from: http://hdl.handle.net/1803/12544

Louisiana State University

4. Gilbert, Nathaniel Carson. Structural and functional insights of human 5-lipoxygenase.

Degree: PhD, 2011, Louisiana State University

URL: etd-04202011-103203 ; https://digitalcommons.lsu.edu/gradschool_dissertations/1747

► This work describes the structure of human 5-lipoxygenase (5-LOX) (Gilbert, Bartlett et al. 2011) and the techniques required to ascertain the structure. 5-LOX is a… (more)

▼ This work describes the structure of human 5-lipoxygenase (5-LOX) (Gilbert, Bartlett et al. 2011) and the techniques required to ascertain the structure. 5-LOX is a notoriously unstable enzyme with important biological functions. The human 5-LOX has been implicated in many disease states including asthma, atherosclerosis and cancer. Part of 5-LOX biology is the inherent instability of the enzyme, which is thought to help regulate the production of its pro-inflammatory products, the leukotrienes. Our objective was stabilizing the enzyme for in vitro studies without affecting catalytic fidelity. I was able to quantitate stabilizing and destabilizing point mutations of 5-LOX by thermal denaturation and kinetic analysis along with other biochemical techniques. Through rigorous site-directed mutagenesis experiments and multiple expression protocols, I was able to over-express an engineered form of 5-LOX that is soluble and stable for biochemical studies and most importantly amenable to crystallization. Our lab is the first to crystallize a human lipoxygenase and model the molecular details. Another objective was studying the effect of phosphorylation on specific serine residues in 5-LOX that have been previously shown to be phosphorylated in vivo. I focused on phosphorylation of Ser663, which is ten amino acids removed from the C-terminus that penetrates the 5-LOX body and binds to the catalytic iron. I mutated this Ser663 to an aspartate, which is a mutation that has been previously shown to mimic a phosphorylated serine. The mutant 5-LOX S663D has altered product specificity in that it oxygenates arachidonic acid (AA) on the 15 carbon preferentially instead of the 5 carbon. This dual specificity of 5-LOX could alter the amounts of the pro- and/or anti-inflammatory compounds present at sites of activation. With the structure of human 5-LOX solved and with reproducible crystal conditions, I began co-crystallization trials of 5-LOX with AA but devoid of oxygen, the other substrate. This would allow visualization of the important substrate binding amino acids and the catalytic machinery necessary for leukotriene production. I was able to model the placement of AA into the active site of Stable-5-LOX S663D, and this structure revealed striking conformational changes required for substrate binding. With these structural studies along with future co-crystallization studies with inhibitors, I will be able to describe amino acids important for catalysis. These insights afforded from co-crystal structures could aid in the development of therapies for the treatment of certain diseases caused by 5-LOX.

Subjects/Keywords: structure; arachidonic acid; 5-lipoxygenase

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APA (6^th Edition):

Gilbert, N. C. (2011). Structural and functional insights of human 5-lipoxygenase. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-04202011-103203 ; https://digitalcommons.lsu.edu/gradschool_dissertations/1747

Chicago Manual of Style (16^th Edition):

Gilbert, Nathaniel Carson. “Structural and functional insights of human 5-lipoxygenase.” 2011. Doctoral Dissertation, Louisiana State University. Accessed January 23, 2021. etd-04202011-103203 ; https://digitalcommons.lsu.edu/gradschool_dissertations/1747.

MLA Handbook (7^th Edition):

Gilbert, Nathaniel Carson. “Structural and functional insights of human 5-lipoxygenase.” 2011. Web. 23 Jan 2021.

Vancouver:

Gilbert NC. Structural and functional insights of human 5-lipoxygenase. [Internet] [Doctoral dissertation]. Louisiana State University; 2011. [cited 2021 Jan 23]. Available from: etd-04202011-103203 ; https://digitalcommons.lsu.edu/gradschool_dissertations/1747.

Council of Science Editors:

Gilbert NC. Structural and functional insights of human 5-lipoxygenase. [Doctoral Dissertation]. Louisiana State University; 2011. Available from: etd-04202011-103203 ; https://digitalcommons.lsu.edu/gradschool_dissertations/1747

Cornell University

5. Tyburczy, Cynthia. Effect Of Dietary Arachidonic Acid (Ara) Level And Source On Neonatal Piglet Development.

Degree: PhD, Nutrition, 2011, Cornell University

URL: http://hdl.handle.net/1813/33495

► Arachidonic acid (ARA) is a long chain polyunsaturated fatty acid that is routinely added to infant formula with docosahexaenoic acid (DHA) to support neonatal growth… (more)

▼ Arachidonic acid (ARA) is a long chain polyunsaturated fatty acid that is routinely added to infant formula with docosahexaenoic acid (DHA) to support neonatal growth and development. Optimal levels of ARA in formula remain to be determined and are based largely on mean worldwide values in breast milk. The objective of this dissertation research was to determine the role of dietary ARA in neonatal development and to evaluate the optimal level in formula to support proper growth and development. Two studies with neonatal domestic pigs were carried out to achieve this objective. The purpose of the first study was to determine the effect of the dietary ARA level on growth, clinical chemistry and immune function, and on tissue ARA and DHA accretion. On day 3 of age, formula-reared (FR) piglets were assigned to 1 of 6 milk replacer formulas containing ARA/DHA as follows (% fatty acid (FA)/FA): (a1) 0.1/1.0; (a2) 0.53/1.0; (a3-d3) 0.69/1.0; (a4) 1.1/1.0; (d2) 0.67/0.62; (d1) 0.66/0.33. No significant differences were observed among the FR groups for growth, hemogram, clinical chemistry or measures of immune status. Heart and liver ARA were responsive to dietary ARA while brain and retina were not. Heart ARA was particularly sensitive to dietary ARA. In the second study, we evaluated two ARA oils for potential use in infant formula compared with a third, commercially available ARA oil. Diets were fed on days 3 - 22 of life and supplied ARA at 0.64% FA and DHA at 0.34% FA. We observed no toxicological effects or differences in growth, and concluded that the experimental ARA oils are safe and bioequivalent to the commercially available ARA source. Overall, results from this dissertation research suggest that the dietary ARA level has a negligible effect on growth and development of the central nervous and immune systems when DHA is supplied near the high end of human breast milk levels (1% FA). The unique responsiveness of the heart to dietary ARA level revealed that ARA accretion is limited by dietary supply. Further investigations are warranted to determine the significance of ARA status on immediate and long term cardiac physiology. Advisors/Committee Members: Brenna, James Thomas (chair), Loew, Ellis Roger (committee member), Feigenson, Gerald W (committee member), Qi, Ling (committee member).

Subjects/Keywords: Arachidonic acid; Polyunsaturated fatty acid; Piglet

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APA (6^th Edition):

Tyburczy, C. (2011). Effect Of Dietary Arachidonic Acid (Ara) Level And Source On Neonatal Piglet Development. (Doctoral Dissertation). Cornell University. Retrieved from http://hdl.handle.net/1813/33495

Chicago Manual of Style (16^th Edition):

Tyburczy, Cynthia. “Effect Of Dietary Arachidonic Acid (Ara) Level And Source On Neonatal Piglet Development.” 2011. Doctoral Dissertation, Cornell University. Accessed January 23, 2021. http://hdl.handle.net/1813/33495.

MLA Handbook (7^th Edition):

Tyburczy, Cynthia. “Effect Of Dietary Arachidonic Acid (Ara) Level And Source On Neonatal Piglet Development.” 2011. Web. 23 Jan 2021.

Vancouver:

Tyburczy C. Effect Of Dietary Arachidonic Acid (Ara) Level And Source On Neonatal Piglet Development. [Internet] [Doctoral dissertation]. Cornell University; 2011. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1813/33495.

Council of Science Editors:

Tyburczy C. Effect Of Dietary Arachidonic Acid (Ara) Level And Source On Neonatal Piglet Development. [Doctoral Dissertation]. Cornell University; 2011. Available from: http://hdl.handle.net/1813/33495

University of Namibia

6. Shuuluka, D. Optimization conditions for the production of Arachidonic acid by the microalga Parietochloris Incisa under indoors and outdoors conditions .

Degree: 2005, University of Namibia

URL: http://hdl.handle.net/11070/1493

► The freshwater green microalga Parietochloris incisa is the richest known plant source of the polyunsaturated fatty acid (PUFA), arachidonic acid (20:4ω6, AA). Accumulation of AA… (more)

▼ The freshwater green microalga Parietochloris incisa is the richest known plant source of the polyunsaturated fatty acid (PUFA), arachidonic acid (20:4ω6, AA). Accumulation of AA and docosahexaenoic acid (22:0, DHA) is necessary for brain and retina development in infants. While many microalgae accumulate triacylglycerols (TAG) in the stationary phase or under certain stress conditions, these TAG are generally made of saturated and monounsaturated fatty acids. In contrast, most cellular AA of P. incisa resides in TAG. This is of practical value, since TAGs are the preferred chemicals to introduce AA into baby formulae. Studies using different cultures conditions were carried out to assess their effects on AA production. Under different cell densities, low, medium and high (LD, MD and HD, respectively), the cells of P. incisa showed a different pattern of chlorophyll content. At LD, cells followed the process of nitrogen starvation, decrease in chlorophyll content, accumulation of carotenoids and showed signs of bleaching at the end of cultivation period. In the same way, cells grown at MD followed the same pattern though it was not more pronounced compared to the former. However, at HD, cells continued to increase the chlorophyll content, probably by continuing to build the photosynthetic membranes to maximize light harvesting. The AA content increased in all cultures irrespective of the initial cell density. Volumetric biomass accumulation was higher in HD cultures, eventually the volumetric AA yield was also higher. The growth stage at which cultures were transferred to N-free medium had a pronounced effect on chlorophyll synthesis of P. incisa. The rate of chlorophyll synthesis was faster in cultures transferred in EXP (exponential) and TRANS (transition) phases. Similarly, the biomass accumulation was rapid in cultures transferred in the EXP and TRANS phases. The proportion of AA of total fatty acid increased faster in cultures transferred to N- starvation in the EXP and TRANS phases of growth. The proportion of AA almost doubled from 25.8% to 47.5% and from 25.8% to 49.8% of TFA, respectively at day 14. Cultures transferred in the E.STA (early stationary) and M.STA (middle stationary) phases of growth, had higher initial proportion of AA, amounting to 34.9% and 36.3%, respectively, at day 0. Their proportion of AA had increased slowly throughout the cultivation period, reaching 47.3% and 47.0% at the end of cultivation period. Cultures growing on complete medium and supplemented with fatty acid precursors were able to incorporate and further modify both incorporated oleic acid and linoleic acid to AA. This was evident only with 3d cultures at the EXP stage. Older cultures did not demonstrate an enhancement in AA production, but rather a reduction. Supplementation of N-starved cultures did not enhance AA production. Increasing the C/N ratio favors lipid accumulation in microalgae by inducing de novo lipid synthesis. Indeed, high CO2 significantly enhanced the TFA synthesis in P. incisa indicating that under…

Subjects/Keywords: Arachidonic acid ; MicroalgaParietochloris

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APA (6^th Edition):

Shuuluka, D. (2005). Optimization conditions for the production of Arachidonic acid by the microalga Parietochloris Incisa under indoors and outdoors conditions . (Thesis). University of Namibia. Retrieved from http://hdl.handle.net/11070/1493

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shuuluka, D. “Optimization conditions for the production of Arachidonic acid by the microalga Parietochloris Incisa under indoors and outdoors conditions .” 2005. Thesis, University of Namibia. Accessed January 23, 2021. http://hdl.handle.net/11070/1493.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shuuluka, D. “Optimization conditions for the production of Arachidonic acid by the microalga Parietochloris Incisa under indoors and outdoors conditions .” 2005. Web. 23 Jan 2021.

Vancouver:

Shuuluka D. Optimization conditions for the production of Arachidonic acid by the microalga Parietochloris Incisa under indoors and outdoors conditions . [Internet] [Thesis]. University of Namibia; 2005. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/11070/1493.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shuuluka D. Optimization conditions for the production of Arachidonic acid by the microalga Parietochloris Incisa under indoors and outdoors conditions . [Thesis]. University of Namibia; 2005. Available from: http://hdl.handle.net/11070/1493

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

7. Shah, Sachin N. Biotransformation: in synthesis of bioactive molecules, 19-HETE and 20-HETE, from Arachidonic acid.

Degree: 2006, University of Pune

URL: http://shodhganga.inflibnet.ac.in/handle/10603/2219

►

The major objectives of the thesis were to explore the biotransformation of arachidonic acid for production of 19-HETE and 20-HETE using Candida bombicola. Chapter one… (more)

Subjects/Keywords: Biotechnology; Biochemical Science; Bioactive Molecules; Arachidonic acid

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APA (6^th Edition):

Shah, S. N. (2006). Biotransformation: in synthesis of bioactive molecules, 19-HETE and 20-HETE, from Arachidonic acid. (Thesis). University of Pune. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/2219

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shah, Sachin N. “Biotransformation: in synthesis of bioactive molecules, 19-HETE and 20-HETE, from Arachidonic acid.” 2006. Thesis, University of Pune. Accessed January 23, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/2219.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shah, Sachin N. “Biotransformation: in synthesis of bioactive molecules, 19-HETE and 20-HETE, from Arachidonic acid.” 2006. Web. 23 Jan 2021.

Vancouver:

Shah SN. Biotransformation: in synthesis of bioactive molecules, 19-HETE and 20-HETE, from Arachidonic acid. [Internet] [Thesis]. University of Pune; 2006. [cited 2021 Jan 23]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2219.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Shah SN. Biotransformation: in synthesis of bioactive molecules, 19-HETE and 20-HETE, from Arachidonic acid. [Thesis]. University of Pune; 2006. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/2219

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

8. Wen, Zhiyou. A high yield and productivity strategy for eicosapentaenoic acid production by the diatom Nitzschia laevis in heterotrophic culture.

Degree: 2001, University of Hong Kong

URL: http://hdl.handle.net/10722/36182

Subjects/Keywords: Arachidonic acid.; Nitzschia.

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APA (6^th Edition):

Wen, Z. (2001). A high yield and productivity strategy for eicosapentaenoic acid production by the diatom Nitzschia laevis in heterotrophic culture. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/36182

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wen, Zhiyou. “A high yield and productivity strategy for eicosapentaenoic acid production by the diatom Nitzschia laevis in heterotrophic culture.” 2001. Thesis, University of Hong Kong. Accessed January 23, 2021. http://hdl.handle.net/10722/36182.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wen, Zhiyou. “A high yield and productivity strategy for eicosapentaenoic acid production by the diatom Nitzschia laevis in heterotrophic culture.” 2001. Web. 23 Jan 2021.

Vancouver:

Wen Z. A high yield and productivity strategy for eicosapentaenoic acid production by the diatom Nitzschia laevis in heterotrophic culture. [Internet] [Thesis]. University of Hong Kong; 2001. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10722/36182.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wen Z. A high yield and productivity strategy for eicosapentaenoic acid production by the diatom Nitzschia laevis in heterotrophic culture. [Thesis]. University of Hong Kong; 2001. Available from: http://hdl.handle.net/10722/36182

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

9. Umunakwe, Obinna C. A Mechanism for Altered Polyunsaturated Fatty Acid Biosynthesis in Cystic Fibrosis.

Degree: PhD, Pathology, 2014, Vanderbilt University

URL: http://hdl.handle.net/1803/13452

► Cystic fibrosis (CF) is a debilitating, multi-organ, autosomal recessive disease caused by mutations leading to absence of functional cystic fibrosis transmembrane conductance regulator (CFTR) in… (more)

Subjects/Keywords: desaturase; arachidonic acid; linoleic acid; AMP-activated protein kinase

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APA (6^th Edition):

Umunakwe, O. C. (2014). A Mechanism for Altered Polyunsaturated Fatty Acid Biosynthesis in Cystic Fibrosis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13452

Chicago Manual of Style (16^th Edition):

Umunakwe, Obinna C. “A Mechanism for Altered Polyunsaturated Fatty Acid Biosynthesis in Cystic Fibrosis.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed January 23, 2021. http://hdl.handle.net/1803/13452.

MLA Handbook (7^th Edition):

Umunakwe, Obinna C. “A Mechanism for Altered Polyunsaturated Fatty Acid Biosynthesis in Cystic Fibrosis.” 2014. Web. 23 Jan 2021.

Vancouver:

Umunakwe OC. A Mechanism for Altered Polyunsaturated Fatty Acid Biosynthesis in Cystic Fibrosis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1803/13452.

Council of Science Editors:

Umunakwe OC. A Mechanism for Altered Polyunsaturated Fatty Acid Biosynthesis in Cystic Fibrosis. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://hdl.handle.net/1803/13452

Vanderbilt University

10. Katrangi, Waddah. The role of polyunsaturated fatty acid and eicosanoid biosynthesis in the pathogenesis of cystic fibrosis.

Degree: PhD, Pathology, 2014, Vanderbilt University

URL: http://hdl.handle.net/1803/12687

► The primary cause of morbidity and mortality in cystic fibrosis is progressive pulmonary disease, an important component of which is a hyperactive inflammatory response, the… (more)

▼ The primary cause of morbidity and mortality in cystic fibrosis is progressive pulmonary disease, an important component of which is a hyperactive inflammatory response, the mechanisms of which are not completely understood. Previous studies have highlighted alterations in polyunsaturated fatty acid and eicosanoid metabolism in cystic fibrosis airway epithelial cells leading to increased arachidonic acid and its metabolites, the pro-inflammatory leukotrienes and prostaglandins. This work tests the hypothesis that these underlying metabolic abnormalities play an important role in the excessive inflammatory response. Using airway epithelial cell culture models of cystic fibrosis, we demonstrate that there is increased release of AA in response to stimulation in CF cells. Additionally, we show that enzymes of fatty acid and eicosanoid metabolism, including Δ6-desaturase, cytosolic phospholipase A2, cyclooxygenase-2, microsomal PGE2 synthase, and 5-lipoxygenase, are upregulated in cystic fibrosis cells compared to wild-type counterparts. These increases are exaggerated when the cells are stimulated with products of Pseudomonas aeruginosa culture, leading to increased production of PGE2 and LTB4 and the pro-inflammatory cytokines IL-6 and IL-8. Inhibition of the LTB4 synthesis pathway at any of multiple points results in blunting of both cyclooxygenase-2 expression and IL-6 and IL-8 production, while inhibition of cyclooxygenase-2 itself results in only minor suppression of cytokine production. Similar results are seen with docosahexaenoic acid, an anti-inflammatory n-3 fatty acid. Taken together, these results indicate that fatty acid and eicosanoid metabolic abnormalities that are intrinsic to epithelial cells in cystic fibrosis, particularly the LTB4 synthesis pathway, may play an important role in the hyperactive inflammatory response characteristic of this disease. Advisors/Committee Members: Michael Laposata, M.D., Ph.D. (committee member), Claus Schneider, Ph.D. (committee member), Larry L. Swift, Ph.D. (committee member), Adam C. Seegmiller, M.D., Ph.D. (committee member), Amy S. Major, Ph.D. (Committee Chair).

Subjects/Keywords: arachidonic acid; eicosanoid; fatty acid; inflammation; cystic fibrosis

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APA (6^th Edition):

Katrangi, W. (2014). The role of polyunsaturated fatty acid and eicosanoid biosynthesis in the pathogenesis of cystic fibrosis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/12687

Chicago Manual of Style (16^th Edition):

Katrangi, Waddah. “The role of polyunsaturated fatty acid and eicosanoid biosynthesis in the pathogenesis of cystic fibrosis.” 2014. Doctoral Dissertation, Vanderbilt University. Accessed January 23, 2021. http://hdl.handle.net/1803/12687.

MLA Handbook (7^th Edition):

Katrangi, Waddah. “The role of polyunsaturated fatty acid and eicosanoid biosynthesis in the pathogenesis of cystic fibrosis.” 2014. Web. 23 Jan 2021.

Vancouver:

Katrangi W. The role of polyunsaturated fatty acid and eicosanoid biosynthesis in the pathogenesis of cystic fibrosis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2014. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1803/12687.

Council of Science Editors:

Katrangi W. The role of polyunsaturated fatty acid and eicosanoid biosynthesis in the pathogenesis of cystic fibrosis. [Doctoral Dissertation]. Vanderbilt University; 2014. Available from: http://hdl.handle.net/1803/12687

Clemson University

11. Headley, Shannon. Effects of dietary supplementation of conjugated linoleic acid in horses.

Degree: MS, Animal and Veterinary Sciences, 2011, Clemson University

URL: https://tigerprints.clemson.edu/all_theses/1223

► Conjugated linoleic acid (CLA) reduces inflammation via the inhibition of cyclooxygenase II , thus reducing prostaglandin E2 (PGE2) production. Conjugated linoleic acid has a suggested… (more)

▼ Conjugated linoleic acid (CLA) reduces inflammation via the inhibition of cyclooxygenase II , thus reducing prostaglandin E2 (PGE2) production. Conjugated linoleic acid has a suggested osteoclast-suppressive role in bone remodeling and osteoarthritis, which are dependent on bone resorptive stimulator PGE2. Bone resorption marker, deoxypyridinoline (DPD), and bone formation marker, bone alkaline phosphatase (BAP), have been modulated by CLA supplementation in other species. Recent research in equine exercise physiology investigated dietary supplementation of polyunsaturated fatty acids as a possible prevention and treatment for osteoarthritis, but CLA supplementation has putative effects on skeletal function or inflammation in horses has not been reported. Our objective was to determine the effects of CLA supplementation on PGE2 in synovial fluid, BAP and DPD in serum, stride length and fetlock flexion and extension at the walk and trot, and body condition in healthy horses at maintenance. In a crossover study, 12 mares were blocked by breed, age, and body condition score (BCS) and separated into 2 treatment groups (n = 6/group). Groups were subjected to CLA and corn oil (CO) as an isocaloric control for 6 weeks (wk) separated by a 4-wk period during which treatment was withheld. Corn oil or CLA supplement (mixed isomers; source contained 55% CLA isomers) were incorporated into maintenance-level diets at 0.01% body weight (BW) per d over a six week period. Mares were fed individually and were restricted to dry lots to quantify forage intake. Synovial fluid, blood, rump fat thickness (RFT), BW and BCS were sampled before (d 0) and after (d42) of each feeding period. Walk and trot stride length and fetlock range of motion were assessed on d 0 and d 42 of feeding period 1 only. Immunoassay kits were used to quantify BAP and DPD in serum and PGE2 in synovial fluid. There were no observed differences in BW, RFT or BCS between the CLA and CO groups. While plasma CLA concentrations were higher in horses fed CLA compared to controls (P < 0.001), synovial fluid PGE2, serum BAP and serum DPD did not differ with treatment. Additionally, stride length and fetlock extension were not different at the walk or trot between treatments, nor was fetlock flexion at the walk. Despite absorption and incorporation of CLA into plasma, mares did not experience treatment effects on biochemical markers of joint inflammation, bone metabolism or kinematic performance. Examining the effects of CLA supplementation on horses at varying levels of growth, exercise, and progression of osteoarthritis may reveal more effects as to its potential benefits in the horse. Rate of dietary CLA incorporation, duration of supplementation, and isolated isomer studies may improve our understanding of these fatty acids in the equine diet. Advisors/Committee Members: Vernon, Kristine, Coverdale , Josie, Jenkins , Thomas, Sharp , Julia.

Subjects/Keywords: arachidonic acid; conjugated linoleic acid; horse; nutrition; prostaglandin E2; Animal Sciences

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APA (6^th Edition):

Headley, S. (2011). Effects of dietary supplementation of conjugated linoleic acid in horses. (Masters Thesis). Clemson University. Retrieved from https://tigerprints.clemson.edu/all_theses/1223

Chicago Manual of Style (16^th Edition):

Headley, Shannon. “Effects of dietary supplementation of conjugated linoleic acid in horses.” 2011. Masters Thesis, Clemson University. Accessed January 23, 2021. https://tigerprints.clemson.edu/all_theses/1223.

MLA Handbook (7^th Edition):

Headley, Shannon. “Effects of dietary supplementation of conjugated linoleic acid in horses.” 2011. Web. 23 Jan 2021.

Vancouver:

Headley S. Effects of dietary supplementation of conjugated linoleic acid in horses. [Internet] [Masters thesis]. Clemson University; 2011. [cited 2021 Jan 23]. Available from: https://tigerprints.clemson.edu/all_theses/1223.

Council of Science Editors:

Headley S. Effects of dietary supplementation of conjugated linoleic acid in horses. [Masters Thesis]. Clemson University; 2011. Available from: https://tigerprints.clemson.edu/all_theses/1223

University of Montana

12. Jasuja, Rahul R. Effect of lipoteichoic acids on arachidonic acid metabolism in macrophages.

Degree: MS, 1992, University of Montana

URL: https://scholarworks.umt.edu/etd/7289

Subjects/Keywords: Macrophages.; Arachidonic acid.; Lipoteichoic acid.

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APA (6^th Edition):

Jasuja, R. R. (1992). Effect of lipoteichoic acids on arachidonic acid metabolism in macrophages. (Masters Thesis). University of Montana. Retrieved from https://scholarworks.umt.edu/etd/7289

Chicago Manual of Style (16^th Edition):

Jasuja, Rahul R. “Effect of lipoteichoic acids on arachidonic acid metabolism in macrophages.” 1992. Masters Thesis, University of Montana. Accessed January 23, 2021. https://scholarworks.umt.edu/etd/7289.

MLA Handbook (7^th Edition):

Jasuja, Rahul R. “Effect of lipoteichoic acids on arachidonic acid metabolism in macrophages.” 1992. Web. 23 Jan 2021.

Vancouver:

Jasuja RR. Effect of lipoteichoic acids on arachidonic acid metabolism in macrophages. [Internet] [Masters thesis]. University of Montana; 1992. [cited 2021 Jan 23]. Available from: https://scholarworks.umt.edu/etd/7289.

Council of Science Editors:

Jasuja RR. Effect of lipoteichoic acids on arachidonic acid metabolism in macrophages. [Masters Thesis]. University of Montana; 1992. Available from: https://scholarworks.umt.edu/etd/7289

Vanderbilt University

13. Njoroge, Sarah Wanjiku. Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis.

Degree: PhD, Pathology, 2013, Vanderbilt University

URL: http://hdl.handle.net/1803/13122

► Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Alterations in polyunsaturated fatty acid (PUFA)… (more)

Subjects/Keywords: docosahexaenoic acid; arachidonic acid; desaturase enzymes; reactive oxygen species; Cystic fibrosis fatty acid abnormalities

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APA (6^th Edition):

Njoroge, S. W. (2013). Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13122

Chicago Manual of Style (16^th Edition):

Njoroge, Sarah Wanjiku. “Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis.” 2013. Doctoral Dissertation, Vanderbilt University. Accessed January 23, 2021. http://hdl.handle.net/1803/13122.

MLA Handbook (7^th Edition):

Njoroge, Sarah Wanjiku. “Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis.” 2013. Web. 23 Jan 2021.

Vancouver:

Njoroge SW. Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis. [Internet] [Doctoral dissertation]. Vanderbilt University; 2013. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1803/13122.

Council of Science Editors:

Njoroge SW. Mechanisms of Polyunsaturated Fatty Acid Alterations in Cystic Fibrosis. [Doctoral Dissertation]. Vanderbilt University; 2013. Available from: http://hdl.handle.net/1803/13122

Northeastern University

14. Sonti, Shilpa. Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA).

Degree: PhD, School of Pharmacy, 2016, Northeastern University

URL: http://hdl.handle.net/2047/D20240140

► The metabolite of docosahexaenoic acid (DHA), synaptamide, is reported to mediate the role of DHA in neuritogenesis and synaptogenesis. Our long term goal is to… (more)

Subjects/Keywords: anandamide; arachidonic acid; docosahexaenoic acid; fatty acid amide hydrolase (faah); n27 cells; phospholipid

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APA (6^th Edition):

Sonti, S. (2016). Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA). (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20240140

Chicago Manual of Style (16^th Edition):

Sonti, Shilpa. “Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA).” 2016. Doctoral Dissertation, Northeastern University. Accessed January 23, 2021. http://hdl.handle.net/2047/D20240140.

MLA Handbook (7^th Edition):

Sonti, Shilpa. “Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA).” 2016. Web. 23 Jan 2021.

Vancouver:

Sonti S. Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA). [Internet] [Doctoral dissertation]. Northeastern University; 2016. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/2047/D20240140.

Council of Science Editors:

Sonti S. Biochemical and functional effects of synaptamide (n-docosahexaenoylethanolamine), a metabolite of docosahexaenoic acid (DHA). [Doctoral Dissertation]. Northeastern University; 2016. Available from: http://hdl.handle.net/2047/D20240140

University of Pretoria

15. [No author]. Uptake of arachidonic acid and glucose into isolated human adipocytes .

Degree: 2008, University of Pretoria

URL: http://upetd.up.ac.za/thesis/available/etd-04112008-163537/

► Both plasma glucose concentration and glucose uptake are deranged in insulin resistance. A high free fatty acid plasma level is a potential cause of insulin… (more)

▼ Both plasma glucose concentration and glucose uptake are deranged in insulin resistance. A high free fatty acid plasma level is a potential cause of insulin resistance, and therefore of type 2 diabetes mellitus animals and humans. The mechanism behind this is still unclear. The objectives of the present study were: (i) to research the effect of arachidonic acid (AA) as fatty acid representative, on glucose uptake into human isolated adipocytes, (ii) to investigate the uptake of AA into adipocyte membranes and nuclei, as a step to identify the mechanism whereby AA affects glucose uptake, and (iii) to verify the influence of insulin on AA uptake in adipocytes. The first objective was achieved by exposing adipocytes to AA and measuring the effect on deoxyglucose uptakt. To achieve the second objective, adipocytes were exposed to 14C-AA; radioactive uptake in membranes and nuclei was determined. The AA uptake into membranes was also determinate by membranes fatty acid profile using gas chromatography; the results of the two methods were compared. Finally, the third objective was achieved by exposing adipocytes to different concentrations of insulin and testing the effect by measuring arachidonic acid uptake by the entire cell. The results of this study shown that, acute (30 min) exposure of AA significantly stimulates glucose uptake by adipocytes (4.56 ± 0.6 nmole glucose /mg protein /min) compared to the control (3.12 ± 0.25 nmole glucose /mg protein /min). Secondly, 14C-AA was significantly taken up by the membranes between 20 and 30 minutes of exposure. The uptake into membranes was increased by 49.57 ± 29% and 123 ± 73% compared to the control 100% (1.77 ± 0.06 nmole AA /mg protein) respectively for 20 and 30 min exposure). AA significantly rose in the nuclei after 30 minutes (147 ± 19% increase) compared to the control 100% (2.25 ± 0.10 nmole AA /mg protein). The determination of AA uptake by gas chromatography analysis of the membrane fatty acid profile showed that the content of AA increased after 30 min exposure (0.57% AA of total membrane fatty acids) compared to the 10 min exposure (0.29% AA of total membrane fatty acid). Insulin was shown to stimulate 10 and 30 min AA uptake by adipocytes from a non-obese subject. The increases of AA uptake measured for 30 minutes were 20 ±8%, 21 ± 25% and 31 ± 4% compared to the control (0.58nmole AA / mg protein / min) respectively for the actions of 10nM, 20nM and 40 nM insulin. A similar tendency was observed when the AA uptake was measured for 10 min (81 ± 31% and 208 ± 36% respectively for the action of 10nM and 40nM insulin compared to the control 100% (0.06nmole AA/mg protein/min). In contrast to this finding, insulin depressed AA uptake by adipocytes from an obese subject (depression of 15 ± 5%, 14 ± 8% and 21 ± 5% respectively for 10nM, 20nM and 40nM insulin, compared to the control 100% (0.74 nmole AA/mg protein/min). In both situations the effect of insulin seemed dose dependent. The study demonstrated that AA acid positively modulates glucose uptake into… Advisors/Committee Members: Prof R Meintjes (advisor), Prof M Haag (advisor).

Subjects/Keywords: Insulin; Arachidonic acid; Glucose; Humans; Animals; Type 2 diabetes mellitus; UCTD

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APA (6^th Edition):

author], [. (2008). Uptake of arachidonic acid and glucose into isolated human adipocytes . (Masters Thesis). University of Pretoria. Retrieved from http://upetd.up.ac.za/thesis/available/etd-04112008-163537/

Chicago Manual of Style (16^th Edition):

author], [No. “Uptake of arachidonic acid and glucose into isolated human adipocytes .” 2008. Masters Thesis, University of Pretoria. Accessed January 23, 2021. http://upetd.up.ac.za/thesis/available/etd-04112008-163537/.

MLA Handbook (7^th Edition):

author], [No. “Uptake of arachidonic acid and glucose into isolated human adipocytes .” 2008. Web. 23 Jan 2021.

Vancouver:

author] [. Uptake of arachidonic acid and glucose into isolated human adipocytes . [Internet] [Masters thesis]. University of Pretoria; 2008. [cited 2021 Jan 23]. Available from: http://upetd.up.ac.za/thesis/available/etd-04112008-163537/.

Council of Science Editors:

author] [. Uptake of arachidonic acid and glucose into isolated human adipocytes . [Masters Thesis]. University of Pretoria; 2008. Available from: http://upetd.up.ac.za/thesis/available/etd-04112008-163537/

University of Rochester

16. Smith, Nathan Anthony. Astrocytes Role in Lipid Mediated Synaptic Activity.

Degree: PhD, 2013, University of Rochester

URL: http://hdl.handle.net/1802/27882

► Astrocytes are a major cell type in both the human and rodent central nervous systems. Due to their inability to be electrically excited, astrocytes have… (more)

▼ Astrocytes are a major cell type in both the human and rodent central nervous systems. Due to their inability to be electrically excited, astrocytes have been viewed as supportive cells providing a suitable environment for neuronal signaling without participating in information processing. This simplistic view has been overturned in the past few decades by evidence showing that astrocytes can respond directly to local neuronal activity with subsequent modification. Neurotransmitters such as glutamate can initiate intracellular Ca2+ signaling in astrocytes that leads to astrocyte release of gliotransmitters, including glutamate, D-serine, ATP or endocannabinoids, which can modulate nearby synaptic strength. Moreover, astrocytes release Arachidonic Acid metabolites, such as PGE2, modulating local blood flow to meet the energy demands of increased neuronal activity. Observations in our lab have demonstrated that vasodilation is seemingly dissociable from astrocytic calcium dynamics in many cases, thus prompting us to test whether astrocytes, through lipid release, can signal on a faster signaling scale in a calciumindependent manner. Thus far, virtually all studies looking at astrocytic signaling mechanisms focus on intracellular Ca2+, which is on a signaling time scale of seconds. However, astrocytes are capable of Ca2+ independent signaling that is potentially on a time scale one to two orders of magnitude faster (msec). In line with this, astrocytes possess Ca2+-independent PLA2 that can lead to the production of AA in the absence of calcium. However, further investigation is needed to reveal the existence of Ca2+- independent signaling from astrocytes and whether this can influence physiological function. We report that upon Ca2+ chelation and receptor stimulation astrocytes can release lipid in a Ca2+ independent manner and that these lipids can indeed affect neuronal signaling. Furthermore, using a model of transient Heterosynaptic Depression (tHSD) in cortical slices, we report that astrocytic modulation of synaptic transmission occurs independent of traditional gliotransmitters, such as ATP and glutamate, but through astrocytic release of endocannabinoids. Taken together, these results provide novel insight into the controversial role of astrocytes in synaptic regulation and thereby in higher information processing.

Subjects/Keywords: Astrocytes; Arachidonic Acid; PGE2; 2AG; Transient Hetero Synaptic Depression; Endo Cannabinoids

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APA (6^th Edition):

Smith, N. A. (2013). Astrocytes Role in Lipid Mediated Synaptic Activity. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/27882

Chicago Manual of Style (16^th Edition):

Smith, Nathan Anthony. “Astrocytes Role in Lipid Mediated Synaptic Activity.” 2013. Doctoral Dissertation, University of Rochester. Accessed January 23, 2021. http://hdl.handle.net/1802/27882.

MLA Handbook (7^th Edition):

Smith, Nathan Anthony. “Astrocytes Role in Lipid Mediated Synaptic Activity.” 2013. Web. 23 Jan 2021.

Vancouver:

Smith NA. Astrocytes Role in Lipid Mediated Synaptic Activity. [Internet] [Doctoral dissertation]. University of Rochester; 2013. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/1802/27882.

Council of Science Editors:

Smith NA. Astrocytes Role in Lipid Mediated Synaptic Activity. [Doctoral Dissertation]. University of Rochester; 2013. Available from: http://hdl.handle.net/1802/27882

University of Alberta

17. Aghazadeh Habashi, Ali. Glucosamine Anti-Inflammatory Dose-Effect Correlation and Its Influence on the Renin-Angiotensin System Components and Arachidonic Acid Metabolites under Inflammatory Condition in the Rat with Adjuvant Arthritis.

Degree: PhD, Faculty of Pharmacy and Pharmaceutical Sciences, 2014, University of Alberta

URL: https://era.library.ualberta.ca/files/2v23vx344

► Crystalline glucosamine (GlcN) sulfate salt formulation is approved as a prescription drug with anti-inflammatory effects for the management of osteoarthritis (OA) in the European Union,… (more)

▼ Crystalline glucosamine (GlcN) sulfate salt formulation is approved as a prescription drug with anti-inflammatory effects for the management of osteoarthritis (OA) in the European Union, while it is considered as a nutraceutical in North America. The effectiveness of GlcN for ameliorating the signs and symptoms of OA in humans is still the subject of scientific debate. In animal studies using high doses, its effectiveness is undisputable; however results of clinical trials in humans are controversial. One of the objectives of this thesis was to address the possible causes of controversy around GlcN effectiveness in humans, and to establish a minimum effective dose (MED) needed to produce minimum anti-inflammatory effective concentration in the rat adjuvant arthritis animal model. Many explanations have been offered as the root of the controversy including superiority of a crystalline sulfate salt over the hydrochloride form, industry bias, insensitive assessment metrics, and poor methodology. Herein, we rule out a difference in bioequivalence between GlcN salts and suggest additional factors; i.e., inconsistency in the GlcN content of some products used in trials, under-dosing of patients, as well as variable pharmacokinetic indices as possible reasons for the lack of GlcN efficacy observed in some studies. Clinical trials using high doses of pharmaceutical grade GlcN, or formulations with greater bioavailability should yield positive results. Our results indicate that the MED is between 40 to 80 mg/kg/day that generates a maximum plasma concentration in the range of 1.37 ± 0.24 to 5.31± 6.84 mg/L, close to the rang of concentration reported for pharmaceutical grades of GlcN in humans. GlcN efficacy is dose and concentration dependent and if the data could be extrapolated to humans, using a higher than the commonly tested 1500 mg/kg /day dosage regimen may provide more clear treatment outcomes. Inflammation influences the body as whole and imbalances the homeostasis of different regulatory systems in particular. Renin-angiotensin system (RAS) and arachidonic acid (ArA) pathway are two main regulators of cardiovascular (CV) systems which could be affected by inflammation. Other objectives of this thesis were to investigate if experimentally induced adjuvant arthritis (AA), as an animal model for systemic inflammation, alters different components of the RAS such as angiotensin converting enzymes (ACE) expression, angiotensin (Ang) peptides systemic and local concentration, and their associated receptors expression level. We also investigated the effect of AA on ArA metabolites concentration in the plasma, heart and kidney tissues. We correlated the RAS components and ArA metabolites concentration in order to identify reliable biomarkers for prediction of CV complications in vulnerable individuals suffering from inflammatory conditions such as rheumatoid arthritis (RA). GlcN with anti-inflammatory effects is a good candidate for modulating the detrimental effect of inflammation on the RAS and ArA pathways. We studied…

Subjects/Keywords: Anti-inflammatory; Glucosamine; Rat; Arachidonic acid; Adjuvant Arthritis; Renin-angiotensin system

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APA (6^th Edition):

Aghazadeh Habashi, A. (2014). Glucosamine Anti-Inflammatory Dose-Effect Correlation and Its Influence on the Renin-Angiotensin System Components and Arachidonic Acid Metabolites under Inflammatory Condition in the Rat with Adjuvant Arthritis. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/2v23vx344

Chicago Manual of Style (16^th Edition):

Aghazadeh Habashi, Ali. “Glucosamine Anti-Inflammatory Dose-Effect Correlation and Its Influence on the Renin-Angiotensin System Components and Arachidonic Acid Metabolites under Inflammatory Condition in the Rat with Adjuvant Arthritis.” 2014. Doctoral Dissertation, University of Alberta. Accessed January 23, 2021. https://era.library.ualberta.ca/files/2v23vx344.

MLA Handbook (7^th Edition):

Aghazadeh Habashi, Ali. “Glucosamine Anti-Inflammatory Dose-Effect Correlation and Its Influence on the Renin-Angiotensin System Components and Arachidonic Acid Metabolites under Inflammatory Condition in the Rat with Adjuvant Arthritis.” 2014. Web. 23 Jan 2021.

Vancouver:

Aghazadeh Habashi A. Glucosamine Anti-Inflammatory Dose-Effect Correlation and Its Influence on the Renin-Angiotensin System Components and Arachidonic Acid Metabolites under Inflammatory Condition in the Rat with Adjuvant Arthritis. [Internet] [Doctoral dissertation]. University of Alberta; 2014. [cited 2021 Jan 23]. Available from: https://era.library.ualberta.ca/files/2v23vx344.

Council of Science Editors:

Aghazadeh Habashi A. Glucosamine Anti-Inflammatory Dose-Effect Correlation and Its Influence on the Renin-Angiotensin System Components and Arachidonic Acid Metabolites under Inflammatory Condition in the Rat with Adjuvant Arthritis. [Doctoral Dissertation]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/2v23vx344

University of Alberta

18. Schulz, Richard. Arachidonic acid metabolism in cerebral arteries: relevance to cerebral vasospasm.

Degree: PhD, Department of Pharmacology, 1989, University of Alberta

URL: https://era.library.ualberta.ca/files/3f462723b

Subjects/Keywords: Arachidonic acid – Metabolism.; Cerebrovascular spasm.

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APA (6^th Edition):

Schulz, R. (1989). Arachidonic acid metabolism in cerebral arteries: relevance to cerebral vasospasm. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/3f462723b

Chicago Manual of Style (16^th Edition):

Schulz, Richard. “Arachidonic acid metabolism in cerebral arteries: relevance to cerebral vasospasm.” 1989. Doctoral Dissertation, University of Alberta. Accessed January 23, 2021. https://era.library.ualberta.ca/files/3f462723b.

MLA Handbook (7^th Edition):

Schulz, Richard. “Arachidonic acid metabolism in cerebral arteries: relevance to cerebral vasospasm.” 1989. Web. 23 Jan 2021.

Vancouver:

Schulz R. Arachidonic acid metabolism in cerebral arteries: relevance to cerebral vasospasm. [Internet] [Doctoral dissertation]. University of Alberta; 1989. [cited 2021 Jan 23]. Available from: https://era.library.ualberta.ca/files/3f462723b.

Council of Science Editors:

Schulz R. Arachidonic acid metabolism in cerebral arteries: relevance to cerebral vasospasm. [Doctoral Dissertation]. University of Alberta; 1989. Available from: https://era.library.ualberta.ca/files/3f462723b

Penn State University

19. Linton, Samuel Scott. Nanoparticle-Mediated Communication in the Pancreatic Tumor Microenvironment.

Degree: 2017, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/14352ssl136

► Pancreatic ductal adenocarcinoma (PDAC) is the most common and deadliest form of pancreatic cancer. Although surgical resection can be curative, 80-85% of PDAC patients are… (more)

▼ Pancreatic ductal adenocarcinoma (PDAC) is the most common and deadliest form of pancreatic cancer. Although surgical resection can be curative, 80-85% of PDAC patients are not candidates for surgical resection. Chemotherapy with gemcitabine or 5-FU, although largely ineffective and hampered by dose-limiting toxicities, is the only treatment option for most patients. Nanoparticle-encapsulation of chemotherapeutic agents has been shown to improve drug delivery and reduce off-target effects. Our research team has designed, synthesized, and tested a novel drug nanocarrier, calcium phosphosilicate nanoparticles (CPSNPs). CPSNPs were loaded with FdUMP, the active, phosphorylated metabolite of 5-fluorouracil, or gemcitabine monophosphate, a bioactive analogue of gemcitabine. Drug-loaded CPSNPs were surface-decorated with DNA aptamers which bind to the CCKB receptor. Aptamer-targeted CPSNPs showed enhanced delivery of FdUMP payloads to mice bearing orthotopic pancreatic tumors, as evidenced by a significant reduction in thymidylate synthase, the FdUMP target enzyme. This work demonstrated that aptamer-targeted CPSNPs can selectively deliver active drug to tumors in vivo. Targeted drug delivery has the potential to enhance efficacy of chemotherapeutics and simultaneously reduce toxicity. The PDAC tumor microenvironment (TME) is comprised of multiple cell types, including tumor-associated macrophages (TAMs). Tumor cells, TAMs, and other TME cell types are in constant communication. One way in which cells communicate is through exosomes, the body’s endogenous nanoparticles. Although much is known about exosomal proteins and nucleic acids, including mRNA and miRNA, relatively few studies have addressed the lipid component of exosomes. We compared the lipid composition of exosomes from various PDAC cell lines and from normal pancreatic ductal cells (HPDE). This analysis found that exosomes from AsPC-1, a highly aggressive pancreatic cancer cell line, are enriched in the bioactive lipid arachidonic acid. Functionally, AsPC-1 exosomes fused at a higher rate with THP-1-derived macrophages and polarized macrophages to an immunosuppressive M2 phenotype. AsPC-1 exosomes also significantly enhanced macrophage secretion of pro-tumoral factors including PGE2, VEGF, MCP-1, IL-6, IL-1β, MMP-9, and TNFα. This work details exogenous and endogenous nanoparticle-mediated intercellular communication in the PDAC TME, an enhanced understanding of which will inform the development of next-generation treatments for PDAC patients. Advisors/Committee Members: Gail Lynn Matters, Dissertation Advisor/Co-Advisor, Gail Lynn Matters, Committee Chair/Co-Chair, Kent Eugene Vrana, Committee Member, Oranee Tawatnuntachai, Committee Member, Gary Alan Clawson, Outside Member, Peter J Butler, Outside Member, Mark Kester, Special Member.

Subjects/Keywords: Nanoparticle; Macrophage; Fusion; Exosome; Arachidonic Acid; Pancreatic Cancer

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APA (6^th Edition):

Linton, S. S. (2017). Nanoparticle-Mediated Communication in the Pancreatic Tumor Microenvironment. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/14352ssl136

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Linton, Samuel Scott. “Nanoparticle-Mediated Communication in the Pancreatic Tumor Microenvironment.” 2017. Thesis, Penn State University. Accessed January 23, 2021. https://submit-etda.libraries.psu.edu/catalog/14352ssl136.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Linton, Samuel Scott. “Nanoparticle-Mediated Communication in the Pancreatic Tumor Microenvironment.” 2017. Web. 23 Jan 2021.

Vancouver:

Linton SS. Nanoparticle-Mediated Communication in the Pancreatic Tumor Microenvironment. [Internet] [Thesis]. Penn State University; 2017. [cited 2021 Jan 23]. Available from: https://submit-etda.libraries.psu.edu/catalog/14352ssl136.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Linton SS. Nanoparticle-Mediated Communication in the Pancreatic Tumor Microenvironment. [Thesis]. Penn State University; 2017. Available from: https://submit-etda.libraries.psu.edu/catalog/14352ssl136

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Eastern Michigan University

20. Grenke, Holly. Synthesis of pinane thromboxane A₂ via suzuki-miyaura coupling.

Degree: MS, Chemistry, 2015, Eastern Michigan University

URL: https://commons.emich.edu/theses/610

► In 1975, Hamberg and associates [1] discovered that human platelets transform arachidonic acid into prostaglandin endoperoxides then further into thromboxane B₂ through the unstable… (more)

Subjects/Keywords: Arachidonic acid; blood platelets aggregation; blood platelets; Chemistry

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APA (6^th Edition):

Grenke, H. (2015). Synthesis of pinane thromboxane A₂ via suzuki-miyaura coupling. (Thesis). Eastern Michigan University. Retrieved from https://commons.emich.edu/theses/610

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Grenke, Holly. “Synthesis of pinane thromboxane A₂ via suzuki-miyaura coupling.” 2015. Thesis, Eastern Michigan University. Accessed January 23, 2021. https://commons.emich.edu/theses/610.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Grenke, Holly. “Synthesis of pinane thromboxane A₂ via suzuki-miyaura coupling.” 2015. Web. 23 Jan 2021.

Vancouver:

Grenke H. Synthesis of pinane thromboxane A₂ via suzuki-miyaura coupling. [Internet] [Thesis]. Eastern Michigan University; 2015. [cited 2021 Jan 23]. Available from: https://commons.emich.edu/theses/610.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Grenke H. Synthesis of pinane thromboxane A₂ via suzuki-miyaura coupling. [Thesis]. Eastern Michigan University; 2015. Available from: https://commons.emich.edu/theses/610

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Uppsala University

21. Xiong, Ye. Early dietary effects of arachidonic acid on gene expression linked to immune response and metabolism in rural and urban Great Tit (Parus Major) nestlings.

Degree: Biology Education Centre, 2017, Uppsala University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-339547

► This study was conducted to test the silver spoon hypothesis that earlylife nutritional conditions impact development, performance and fitness of the birdsgreat tit (Parus… (more)

Subjects/Keywords: gene expression; dietary manipulation; arachidonic acid; Evolutionary Biology; Evolutionsbiologi

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APA (6^th Edition):

Xiong, Y. (2017). Early dietary effects of arachidonic acid on gene expression linked to immune response and metabolism in rural and urban Great Tit (Parus Major) nestlings. (Thesis). Uppsala University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-339547

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Xiong, Ye. “Early dietary effects of arachidonic acid on gene expression linked to immune response and metabolism in rural and urban Great Tit (Parus Major) nestlings.” 2017. Thesis, Uppsala University. Accessed January 23, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-339547.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Xiong, Ye. “Early dietary effects of arachidonic acid on gene expression linked to immune response and metabolism in rural and urban Great Tit (Parus Major) nestlings.” 2017. Web. 23 Jan 2021.

Vancouver:

Xiong Y. Early dietary effects of arachidonic acid on gene expression linked to immune response and metabolism in rural and urban Great Tit (Parus Major) nestlings. [Internet] [Thesis]. Uppsala University; 2017. [cited 2021 Jan 23]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-339547.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xiong Y. Early dietary effects of arachidonic acid on gene expression linked to immune response and metabolism in rural and urban Great Tit (Parus Major) nestlings. [Thesis]. Uppsala University; 2017. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-339547

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

22. Usman, Rukhsana. Platelet activity and arachidonic acid metabolism: modulation by factors in plasma and cerebrospinal fluidand by diet.

Degree: 1994, University of Hong Kong

URL: http://hdl.handle.net/10722/34553

Subjects/Keywords: Arachidonic acid.; Platelet activating factor.

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APA (6^th Edition):

Usman, R. (1994). Platelet activity and arachidonic acid metabolism: modulation by factors in plasma and cerebrospinal fluidand by diet. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/34553

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Usman, Rukhsana. “Platelet activity and arachidonic acid metabolism: modulation by factors in plasma and cerebrospinal fluidand by diet.” 1994. Thesis, University of Hong Kong. Accessed January 23, 2021. http://hdl.handle.net/10722/34553.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Usman, Rukhsana. “Platelet activity and arachidonic acid metabolism: modulation by factors in plasma and cerebrospinal fluidand by diet.” 1994. Web. 23 Jan 2021.

Vancouver:

Usman R. Platelet activity and arachidonic acid metabolism: modulation by factors in plasma and cerebrospinal fluidand by diet. [Internet] [Thesis]. University of Hong Kong; 1994. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10722/34553.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Usman R. Platelet activity and arachidonic acid metabolism: modulation by factors in plasma and cerebrospinal fluidand by diet. [Thesis]. University of Hong Kong; 1994. Available from: http://hdl.handle.net/10722/34553

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Louisiana State University

23. Kobe, Matthew James. Structural and Kinetic Investigations of 15-Lipoxygenase-2.

Degree: PhD, 2014, Louisiana State University

URL: etd-04102015-162654 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2220

► Evidence suggests that 15-lipoxygenase-2 (15-LOX-2) plays an important role in the progression of atherosclerosis. Due to the medical need to discover isoform specific inhibitors of… (more)

Subjects/Keywords: membrane binding; arachidonic acid; structure; crystallography; 15-lipoxygenase-2

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APA (6^th Edition):

Kobe, M. J. (2014). Structural and Kinetic Investigations of 15-Lipoxygenase-2. (Doctoral Dissertation). Louisiana State University. Retrieved from etd-04102015-162654 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2220

Chicago Manual of Style (16^th Edition):

Kobe, Matthew James. “Structural and Kinetic Investigations of 15-Lipoxygenase-2.” 2014. Doctoral Dissertation, Louisiana State University. Accessed January 23, 2021. etd-04102015-162654 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2220.

MLA Handbook (7^th Edition):

Kobe, Matthew James. “Structural and Kinetic Investigations of 15-Lipoxygenase-2.” 2014. Web. 23 Jan 2021.

Vancouver:

Kobe MJ. Structural and Kinetic Investigations of 15-Lipoxygenase-2. [Internet] [Doctoral dissertation]. Louisiana State University; 2014. [cited 2021 Jan 23]. Available from: etd-04102015-162654 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2220.

Council of Science Editors:

Kobe MJ. Structural and Kinetic Investigations of 15-Lipoxygenase-2. [Doctoral Dissertation]. Louisiana State University; 2014. Available from: etd-04102015-162654 ; https://digitalcommons.lsu.edu/gradschool_dissertations/2220

University of Georgia

24. Peterson, Brianna. Role of calcium-independent phospholipase A2 in oxidant-induced neural cell death.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/23958

► Phospholipase A2 (PLA2) are esterases that hydrolyze the sn-2 bond of phospholipids resulting in the release of free fatty acids and lysophospholipids. This study determined… (more)

▼ Phospholipase A2 (PLA2) are esterases that hydrolyze the sn-2 bond of phospholipids resulting in the release of free fatty acids and lysophospholipids. This study determined the roles of calcium-independent PLA2 (iPLA2) in the regulation of phospholipid expression and oxidant-induced cell death in two types of neural cells, astrocytes and neurons. Cells expressed both cytosolic Group VIA (iPLA2²) and microsomal Group VIB (iPLA2³) PLA2 as determined by activity assays and immunoblot analysis. Inhibition of total iPLA2 activity using racemic bromoenol lactone (BEL, 2.5 µM) altered cell death induced by the oxidants hydrogen peroxide (H2O2) or tert-butylhydroperoxide (TBHP). In astrocytes, inhibition of iPLA2 accelerated the loss of ATP levels, but not the formation of reactive oxygen species and induced a significant increase in cells undergoing necrosis as determined by increases in propidium iodide staining. In contrast, inhibition of iPLA2 in neuronal cells protected against H2O2-induced cell death, but not against TBHP-induced cell death. The differential effects of BEL on H2O2 and TBHP-induced cell death correlated to the formation of reactive oxygen species, genesis of lipid peroxidation, and loss of ATP induced by these compounds. In addition, a lipidomic approach was used in combination with electrospray ionization mass spectrometry to determine the effect of oxidant exposure on the phospholipid profiles of astrocytes and neurons. In astrocytes, iPLA2³ was determined to play a greater role than iPLA2² in the maintenance of phosphatidylcholine phospholipids (PtdCho) under physiological conditions. However, oxidant-exposure only slightly altered these phospholipids. In contrast, exposure of neurons to oxidants resulted in significant changes in PtdCho species containing arachidonic acid at the sn-2 position. These changes were altered by the presence of inhibitors of both iPLA2 and cytosolic PLA2 and correlated to the formation of arachidonic acid. These data support the hypothesis that iPLA2 mediates oxidant-induced neural cell death and demonstrates differential roles of iPLA2 isoforms in physiological and pathological events. These data also identify the specific phospholipids and fatty acids targeted by oxidants in neural cell cultures and suggest that iPLA2 may be a therapeutic target for alteration of oxidant-induced neural cell death.

Subjects/Keywords: Phospholipase A2; Phospholipids; Arachidonic Acid; Neural Cells; Oxidant

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APA (6^th Edition):

Peterson, B. (2014). Role of calcium-independent phospholipase A2 in oxidant-induced neural cell death. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/23958

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Peterson, Brianna. “Role of calcium-independent phospholipase A2 in oxidant-induced neural cell death.” 2014. Thesis, University of Georgia. Accessed January 23, 2021. http://hdl.handle.net/10724/23958.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Peterson, Brianna. “Role of calcium-independent phospholipase A2 in oxidant-induced neural cell death.” 2014. Web. 23 Jan 2021.

Vancouver:

Peterson B. Role of calcium-independent phospholipase A2 in oxidant-induced neural cell death. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Jan 23]. Available from: http://hdl.handle.net/10724/23958.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Peterson B. Role of calcium-independent phospholipase A2 in oxidant-induced neural cell death. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/23958

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Montana

25. Taylor, Karyn L. Influence of cell differentiation on arachidonic acid metabolism in stimulated and unstimulated HL-60 cells.

Degree: MS, 1989, University of Montana

URL: https://scholarworks.umt.edu/etd/7476

Subjects/Keywords: Arachidonic acid.; Leukotrienes.; Lipoxins.; Prostaglandins.

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APA (6^th Edition):

Taylor, K. L. (1989). Influence of cell differentiation on arachidonic acid metabolism in stimulated and unstimulated HL-60 cells. (Masters Thesis). University of Montana. Retrieved from https://scholarworks.umt.edu/etd/7476

Chicago Manual of Style (16^th Edition):

Taylor, Karyn L. “Influence of cell differentiation on arachidonic acid metabolism in stimulated and unstimulated HL-60 cells.” 1989. Masters Thesis, University of Montana. Accessed January 23, 2021. https://scholarworks.umt.edu/etd/7476.

MLA Handbook (7^th Edition):

Taylor, Karyn L. “Influence of cell differentiation on arachidonic acid metabolism in stimulated and unstimulated HL-60 cells.” 1989. Web. 23 Jan 2021.

Vancouver:

Taylor KL. Influence of cell differentiation on arachidonic acid metabolism in stimulated and unstimulated HL-60 cells. [Internet] [Masters thesis]. University of Montana; 1989. [cited 2021 Jan 23]. Available from: https://scholarworks.umt.edu/etd/7476.

Council of Science Editors:

Taylor KL. Influence of cell differentiation on arachidonic acid metabolism in stimulated and unstimulated HL-60 cells. [Masters Thesis]. University of Montana; 1989. Available from: https://scholarworks.umt.edu/etd/7476

University of Montana

26. Li, I-ping. Isolation and identification of inhibitory factor(s) of leukotriene D4 dipeptidase in human serum.

Degree: MS, 1991, University of Montana

URL: https://scholarworks.umt.edu/etd/7214

Subjects/Keywords: Leukotrienes.; Serum.; Arachidonic acid.

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APA (6^th Edition):

Li, I. (1991). Isolation and identification of inhibitory factor(s) of leukotriene D4 dipeptidase in human serum. (Masters Thesis). University of Montana. Retrieved from https://scholarworks.umt.edu/etd/7214

Chicago Manual of Style (16^th Edition):

Li, I-ping. “Isolation and identification of inhibitory factor(s) of leukotriene D4 dipeptidase in human serum.” 1991. Masters Thesis, University of Montana. Accessed January 23, 2021. https://scholarworks.umt.edu/etd/7214.

MLA Handbook (7^th Edition):

Li, I-ping. “Isolation and identification of inhibitory factor(s) of leukotriene D4 dipeptidase in human serum.” 1991. Web. 23 Jan 2021.

Vancouver:

Li I. Isolation and identification of inhibitory factor(s) of leukotriene D4 dipeptidase in human serum. [Internet] [Masters thesis]. University of Montana; 1991. [cited 2021 Jan 23]. Available from: https://scholarworks.umt.edu/etd/7214.

Council of Science Editors:

Li I. Isolation and identification of inhibitory factor(s) of leukotriene D4 dipeptidase in human serum. [Masters Thesis]. University of Montana; 1991. Available from: https://scholarworks.umt.edu/etd/7214

University of Montana

27. Wang, Rong. Analysis of eicosanoids released from activated macrophages.

Degree: MS, 1998, University of Montana

URL: https://scholarworks.umt.edu/etd/6653

Subjects/Keywords: Eicosanoids.; Arachidonic acid.; Macrophages.

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APA (6^th Edition):

Wang, R. (1998). Analysis of eicosanoids released from activated macrophages. (Masters Thesis). University of Montana. Retrieved from https://scholarworks.umt.edu/etd/6653

Chicago Manual of Style (16^th Edition):

Wang, Rong. “Analysis of eicosanoids released from activated macrophages.” 1998. Masters Thesis, University of Montana. Accessed January 23, 2021. https://scholarworks.umt.edu/etd/6653.

MLA Handbook (7^th Edition):

Wang, Rong. “Analysis of eicosanoids released from activated macrophages.” 1998. Web. 23 Jan 2021.

Vancouver:

Wang R. Analysis of eicosanoids released from activated macrophages. [Internet] [Masters thesis]. University of Montana; 1998. [cited 2021 Jan 23]. Available from: https://scholarworks.umt.edu/etd/6653.

Council of Science Editors:

Wang R. Analysis of eicosanoids released from activated macrophages. [Masters Thesis]. University of Montana; 1998. Available from: https://scholarworks.umt.edu/etd/6653

The Ohio State University

28. Harder, Hubert Werner. Metabolism of arachidonic and adrenic acids in molecular species of gycerophospholipids in mouse brain.

Degree: PhD, Graduate School, 1986, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu14872651431456

Subjects/Keywords: Chemistry; Arachidonic acid; Phospholipids

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APA (6^th Edition):

Harder, H. W. (1986). Metabolism of arachidonic and adrenic acids in molecular species of gycerophospholipids in mouse brain. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu14872651431456

Chicago Manual of Style (16^th Edition):

Harder, Hubert Werner. “Metabolism of arachidonic and adrenic acids in molecular species of gycerophospholipids in mouse brain.” 1986. Doctoral Dissertation, The Ohio State University. Accessed January 23, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu14872651431456.

MLA Handbook (7^th Edition):

Harder, Hubert Werner. “Metabolism of arachidonic and adrenic acids in molecular species of gycerophospholipids in mouse brain.” 1986. Web. 23 Jan 2021.

Vancouver:

Harder HW. Metabolism of arachidonic and adrenic acids in molecular species of gycerophospholipids in mouse brain. [Internet] [Doctoral dissertation]. The Ohio State University; 1986. [cited 2021 Jan 23]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu14872651431456.

Council of Science Editors:

Harder HW. Metabolism of arachidonic and adrenic acids in molecular species of gycerophospholipids in mouse brain. [Doctoral Dissertation]. The Ohio State University; 1986. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu14872651431456

Universiteit Utrecht

29. Houthuijzen, J.M. The role of polyunsaturated fatty acids in cancer.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/179662

► It has been shown in many studies that life style and high-fat diets can contribute to the risk of development of cancer. Arachidonic acid (AA)… (more)

Subjects/Keywords: Geneeskunde; cancer, omega-3, omega-6, polyunsaturated fatty acids; eicosapentanoic acid, EPA, arachidonic acid, AA

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APA (6^th Edition):

Houthuijzen, J. M. (2010). The role of polyunsaturated fatty acids in cancer. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/179662

Chicago Manual of Style (16^th Edition):

Houthuijzen, J M. “The role of polyunsaturated fatty acids in cancer.” 2010. Masters Thesis, Universiteit Utrecht. Accessed January 23, 2021. http://dspace.library.uu.nl:8080/handle/1874/179662.

MLA Handbook (7^th Edition):

Houthuijzen, J M. “The role of polyunsaturated fatty acids in cancer.” 2010. Web. 23 Jan 2021.

Vancouver:

Houthuijzen JM. The role of polyunsaturated fatty acids in cancer. [Internet] [Masters thesis]. Universiteit Utrecht; 2010. [cited 2021 Jan 23]. Available from: http://dspace.library.uu.nl:8080/handle/1874/179662.

Council of Science Editors:

Houthuijzen JM. The role of polyunsaturated fatty acids in cancer. [Masters Thesis]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/179662

University of Tennessee – Knoxville

30. Rett, Brian. Increasing Dietary Linoleic Acid Does Not Increase Tissue Arachidonic Acid Content in Adults Consuming Western- Type Diets.

Degree: MS, Nutrition, 2011, University of Tennessee – Knoxville

URL: https://trace.tennessee.edu/utk_gradthes/908

► Linoleic acid, with a DRI of 12-17g/d, is the most highly consumed polyunsaturated fatty acid in the Western diet and is found in virtually… (more)

Subjects/Keywords: linoleic acid; arachidonic acid; eicosanoids; n-6; omega-6; Medicine and Health Sciences

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APA (6^th Edition):

Rett, B. (2011). Increasing Dietary Linoleic Acid Does Not Increase Tissue Arachidonic Acid Content in Adults Consuming Western- Type Diets. (Thesis). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_gradthes/908

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rett, Brian. “Increasing Dietary Linoleic Acid Does Not Increase Tissue Arachidonic Acid Content in Adults Consuming Western- Type Diets.” 2011. Thesis, University of Tennessee – Knoxville. Accessed January 23, 2021. https://trace.tennessee.edu/utk_gradthes/908.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rett, Brian. “Increasing Dietary Linoleic Acid Does Not Increase Tissue Arachidonic Acid Content in Adults Consuming Western- Type Diets.” 2011. Web. 23 Jan 2021.

Vancouver:

Rett B. Increasing Dietary Linoleic Acid Does Not Increase Tissue Arachidonic Acid Content in Adults Consuming Western- Type Diets. [Internet] [Thesis]. University of Tennessee – Knoxville; 2011. [cited 2021 Jan 23]. Available from: https://trace.tennessee.edu/utk_gradthes/908.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rett B. Increasing Dietary Linoleic Acid Does Not Increase Tissue Arachidonic Acid Content in Adults Consuming Western- Type Diets. [Thesis]. University of Tennessee – Knoxville; 2011. Available from: https://trace.tennessee.edu/utk_gradthes/908

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations