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You searched for subject:(ApoE Knockout mice). Showing records 1 – 3 of 3 total matches.

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Universidade do Estado do Rio de Janeiro

1. Sebastião Barreto de Brito Filho. Efeito da ingestão crônica de vinho sobre a homeostase glicêmica, lipídica e ponderal em camundongos ApoE Knockout.

Degree: PhD, 2013, Universidade do Estado do Rio de Janeiro

Os benefícios à saúde relacionados ao consumo moderado de vinho incluem diferentes mecanismos, nos quais estão envolvidos tanto etanol quanto compostos fenólicos que são constituintes do mesmo. Com o objetivo de avaliar variações glicêmicas, ponderais e o depósito de triglicérides, colesterol e glicogênio hepáticos com uso regular de vinho tinto em camundongo ApoE Knockout, foram utilizados 60 camundongos machos adultos ApoE Knockout de peso médio de 30 gramas, distribuídos em três grupos de 20 animais: grupo vinho, grupo etanol e grupo água, os quais receberam 50 mL de vinho e 50 mL água, 6mL de etanol e 94mL de água e somente água respectivamente por quatro meses. Os parâmetros avaliados foram: variações glicêmicas, ponderais, acúmulo de triglicerídeos, colesterol e glicogênio hepáticos. O grupo vinho teve em relação a sua massa corporal uma área sob a curva maior que a dos outros dois grupos, mas com um percentual pequeno de aumento. A concentração do triglicerídeo hepático foi maior no grupo vinho 57% em relação ao grupo etanol, que foi 31,6% menor que o controle (p<0,01%). A concentração do colesterol hepático foi menor no grupo vinho (23,6%), assim como no grupo etanol (24,5%), (p<0,05%). A concentração do glicogênio hepático foi maior no grupo vinho (16%), porém não alcançando significado estatístico. A glicemia em jejum no dia da eutanásia foi maior no grupo etanol em relação aos demais grupos, porém não demonstrou diferença estatisticamente significante. Na análise histológica não foi observada diferença significativa entre os grupos, embora o peso médio em gramas nas gorduras, retroperitoneal e subcutâneas tenha sido aproximadamente duas vezes maior no grupo vinho. Concluiu-se que neste estudo o uso regular e crônico de vinho tinto aumentou triglicerídeo hepático, porém o álcool diminui o colesterol hepático. O aumento do triglicerídeo pode ser devido ao alto valor calórico do vinho ou alguma propriedade lipogênica desconhecida que levou ao aumento importante das gorduras retroperitoneais e subcutâneas em camundongos ApoE Knockout.

The benefits to health related to regular consume of red wine includes different mechanisms in which are involved both ethanol and fenolics compounds of the wine. With the objective to evaluate glycemia, lipid profile and weight variations with regular use of red wine by ApoE Knockout mices, sixty adults ApoE Knockout mices weighing around 30g were distributed into 3 groups of 20 animals each: 1.Wine that received 50mL of wine plus 50mL of water, 2. Ethanol and Water groups, 6mL of ethanol plus 94mL of water and just water respectively for 4 months. We evaluate glycemia, weight variations and liver glycogen, triglycerides and cholesterol. The wine group had in relation to its mass body an area under the curve larger than the other two groups, but with a small percentage of increase. The concentration of liver triglycerides was higher in the wine 57% compared to ethanol group, which was 31.6% lower than the control (p<0.01%). The concentration of liver cholesterol was lower in…

Advisors/Committee Members: Egberto Gaspar de Moura, Mariana Sarto Figueiredo, Maria do Rosário da Silva Ramos Costa, Elias Amorim, Orlando José dos Santos, Viviane Younes Rapozo.

Subjects/Keywords: Vinho; Homeostase glicêmica e ponderal; Perfil lipídico; Camundongo ApoE Knockout; Wine; Lipidic profile; Glycemic and weight Homeothasis; ApoE Knockout mice; FISIOLOGIA ENDOCRINA; Vinho Teses; Homeostase Teses; Camundongos Knockout

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APA (6th Edition):

Filho, S. B. d. B. (2013). Efeito da ingestão crônica de vinho sobre a homeostase glicêmica, lipídica e ponderal em camundongos ApoE Knockout. (Doctoral Dissertation). Universidade do Estado do Rio de Janeiro. Retrieved from http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6770 ;

Chicago Manual of Style (16th Edition):

Filho, Sebastião Barreto de Brito. “Efeito da ingestão crônica de vinho sobre a homeostase glicêmica, lipídica e ponderal em camundongos ApoE Knockout.” 2013. Doctoral Dissertation, Universidade do Estado do Rio de Janeiro. Accessed May 20, 2019. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6770 ;.

MLA Handbook (7th Edition):

Filho, Sebastião Barreto de Brito. “Efeito da ingestão crônica de vinho sobre a homeostase glicêmica, lipídica e ponderal em camundongos ApoE Knockout.” 2013. Web. 20 May 2019.

Vancouver:

Filho SBdB. Efeito da ingestão crônica de vinho sobre a homeostase glicêmica, lipídica e ponderal em camundongos ApoE Knockout. [Internet] [Doctoral dissertation]. Universidade do Estado do Rio de Janeiro; 2013. [cited 2019 May 20]. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6770 ;.

Council of Science Editors:

Filho SBdB. Efeito da ingestão crônica de vinho sobre a homeostase glicêmica, lipídica e ponderal em camundongos ApoE Knockout. [Doctoral Dissertation]. Universidade do Estado do Rio de Janeiro; 2013. Available from: http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6770 ;

2. Hayenga, Heather Naomi. Mechanics of Atherosclerosis, Hypertension Induced Growth, and Arterial Remodeling.

Degree: 2012, Texas A&M University

In order to create informed predictive models that capture artery dependent responses during atherosclerosis progression and the long term response to hypertension, one needs to know the structural, biochemical and mechanical properties as a function of time in these diseased states. In the case of hypertension more is known about the mechanical changes; while, less is known about the structural changes over time. For atherosclerotic plaques, more is known about the structure and less about the mechanical properties. We established a congruent multi-scale model to predict the adapted salient arterial geometry, structure and biochemical response to an increase in pressure. Geometrical and structural responses to hypertension were then quantified in a hypertensive animal model. Eventually this type of model may be used to predict mechanical changes in complex disease such as atherosclerosis. Thus for future verification and implementation we experimentally tested atherosclerotic plaques and quantified composition, structure and mechanical properties. Using the theoretical models we can now predict arterial changes in biochemical concentrations as well as salient features such as geometry, mass of elastin, smooth muscle, and collagen, and circumferential stress, in response to hemodynamic loads. Using an aortic coarctation model of hypertension, we found structural arterial responses differ in the aorta, coronary and cerebral arteries. Effects of elevated pressure manifest first in the central arteries and later in distal muscular arteries. In the aorta, there is a loss and then increase of cytoskeleton actin fibers, production of fibrillar collagen and elastin, hyperplasia or hypertrophy with nuclear polypoid, and recruitment of hemopoeitic progenitor cells and monocytes. In the muscular coronary, we see similar changes albeit it appears actin fibers are recruited and collagen production is only increased slightly in order to maintain constant the overall ratio of ~55 percent. In the muscular cerebral artery, despite a temporary loss in actin fibers there is little structural change. Contrary to hypertensive arteries, characterizing regional stiffness in atherosclerotic plaques has not been done before. Therefore, experimental testing on atherosclerotic plaques of Apolipoprotein E Knockout mice was performed and revealed nearly homogenously lipidic plaques with a median axial compressive stiffness value of 1.5 kPa. Advisors/Committee Members: Moore, James E. (advisor), Clubb, Fred J. (committee member), Kaunas, Roland R. (committee member), Yeh, Alvin T. (committee member).

Subjects/Keywords: Mechanobiology; Atomic Force Microscopy; Multiscale Modeling; Growth and Remodeling; ApoE Knockout Mice; Immunoflourescence

…spatial and temporal development of the stenosis are still unknown. 8 ApoE Knockout Mice. One… …Microscopy ApoE-/- Apolipoprotein E Knockout H&E Hematoxylin and Eosin HT Hypertensive LAD… …lesions in ApoE-/- mice histologically and pathologically resemble all known stages of… …x28;A) Plaque was detected by gross examination in the suprarenal aorta from ApoE… …mice aged 42 to 56 weeks .................................................... 112 6.2 (… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hayenga, H. N. (2012). Mechanics of Atherosclerosis, Hypertension Induced Growth, and Arterial Remodeling. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9098

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Hayenga, Heather Naomi. “Mechanics of Atherosclerosis, Hypertension Induced Growth, and Arterial Remodeling.” 2012. Thesis, Texas A&M University. Accessed May 20, 2019. http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9098.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Hayenga, Heather Naomi. “Mechanics of Atherosclerosis, Hypertension Induced Growth, and Arterial Remodeling.” 2012. Web. 20 May 2019.

Vancouver:

Hayenga HN. Mechanics of Atherosclerosis, Hypertension Induced Growth, and Arterial Remodeling. [Internet] [Thesis]. Texas A&M University; 2012. [cited 2019 May 20]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9098.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hayenga HN. Mechanics of Atherosclerosis, Hypertension Induced Growth, and Arterial Remodeling. [Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2011-05-9098

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. Bai, Yuntao. The Effects of PM2.5 Exposure and Freeze-dried Strawberry Supplementation on Atherosclerosis and Inflammation in a Mice Model.

Degree: PhD, Molecular, Cellular and Developmental Biology, 2015, The Ohio State University

Both epidemiological and empirical data have demonstrated the association between long-term exposure to fine particulate matters (PM2.5) and the burden of atherosclerosis. Strawberry, a rich source of micronutrients and several bioactive phytochemicals, has been implicated in the prevention of cardiovascular diseases and metabolic syndromes. This study was designed to explore the effects of freeze-dried strawberry supplementation on PM2.5-potentiated atherosclerosis in apoE-/- mice, which is a spontaneous atherosclerotic model. Mice, fed with high-fat chow or high-fat chow supplemented with 10% strawberry powder, were exposed to either filtered air or concentrated ambient particles using “Ohio Air Pollution Exposure Systems for Interrogation of Systemic Effects” for 6 months. After PM2.5 exposure, plaque area and lipid area of aorta were evaluated using hematoxylin & eosin staining and oil-red O staining, respectively. In addition, total cholesterol, high-density lipoprotein and fasting glucose were measured using diagnostic kits. Furthermore, the levels of inflammatory cytokines in plasma were determined via ELISA kits, and the mRNA expressions of inflammatory cytokines within lung were quantitated using real-time PCR. Our data showed that long-term PM2.5 exposure potentiated atherosclerosis and inflammation in these mice; strawberries reduced inflammation and improved lipid profile, but did not attenuate atherosclerosis after PM2.5 exposure. These findings indicate that other mechanistic pathways, e.g. systemic oxidative stress, autonomic nervous system imbalance, and the direct toxic effects of particles, may diminish the effects of strawberries on PM2.5-potentiated atherosclerosis. Advisors/Committee Members: Sun, Qinghua (Advisor).

Subjects/Keywords: Molecular Biology; Atherosclerosis Strawberry apoE knockout mice Air pollution particulate matters

…enhancement of atherosclerosis after PM2.5 exposure. ApoE-/- mice, fed with high-fat chow, were… …2.5-potentiated atherosclerosis. ApoE-/- mice, fed with high-fat chow with or without… …can potentiate plaque development and vascular inflammation in apoE deficient mice [28… …mice with type 2 diabetes. J Environ Sci (China). 2015 May 1;31:98-103. 10. Ying Z… …loci and elucidating the molecular and physiological mechanisms. Mice deficient in… 

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Bai, Y. (2015). The Effects of PM2.5 Exposure and Freeze-dried Strawberry Supplementation on Atherosclerosis and Inflammation in a Mice Model. (Doctoral Dissertation). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1442917990

Chicago Manual of Style (16th Edition):

Bai, Yuntao. “The Effects of PM2.5 Exposure and Freeze-dried Strawberry Supplementation on Atherosclerosis and Inflammation in a Mice Model.” 2015. Doctoral Dissertation, The Ohio State University. Accessed May 20, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1442917990.

MLA Handbook (7th Edition):

Bai, Yuntao. “The Effects of PM2.5 Exposure and Freeze-dried Strawberry Supplementation on Atherosclerosis and Inflammation in a Mice Model.” 2015. Web. 20 May 2019.

Vancouver:

Bai Y. The Effects of PM2.5 Exposure and Freeze-dried Strawberry Supplementation on Atherosclerosis and Inflammation in a Mice Model. [Internet] [Doctoral dissertation]. The Ohio State University; 2015. [cited 2019 May 20]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1442917990.

Council of Science Editors:

Bai Y. The Effects of PM2.5 Exposure and Freeze-dried Strawberry Supplementation on Atherosclerosis and Inflammation in a Mice Model. [Doctoral Dissertation]. The Ohio State University; 2015. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1442917990

.