subject:(Antipsychotic agents)

University of Houston

1. Chekani, Farid. Safety of Atypical Antipsychotics in the Elderly with Parkinson’s Disease.

Degree: PhD, Pharmacy Leadership & Administration, University of Houston

► Objectives: According to the 2015 American Geriatrics Society (AGS) Beers criteria, except for aripiprazole, clozapine, and quetiapine, antipsychotic medications are considered generally inappropriate in PD.… (more)

▼ Objectives: According to the 2015 American Geriatrics Society (AGS) Beers criteria, except for aripiprazole, clozapine, and quetiapine, antipsychotic medications are considered generally inappropriate in PD. However, limited data exists regarding safety of atypical antipsychotics in general and inappropriate atypical antipsychotics in specific in patients with PD. This study evaluated the incidence and predictors of inappropriate atypical antipsychotic agents among older patients with PD; and the risks of pneumonia and mortality in older patients with PD using inappropriate atypical antipsychotic agents. Methods: A retrospective design involving Minimum Data Set (MDS) linked Medicare claims data was used to examine incidence and predictors of inappropriate atypical antipsychotic agents and to evaluate the study hypotheses that there are higher risks of pneumonia and all-cause mortality among older patients with PD using inappropriate atypical antipsychotics when compared to the three selected atypical antipsychotic agents (i.e. aripiprazole, clozapine, and quetiapine). The inappropriate atypical antipsychotics encompassed olanzapine, asenapine, brexpiprazole, iloperidone, lurasidone, paliperidone, risperidone, and ziprasidone. The study sample was selected from a cohort of older adults with depression. Multivariable logistic regression was used to examine various sociodemographic and clinical factors associated with inappropriate antipsychotic use in PD based on Andersen’s Behavioral Model. Safety evaluation involved a propensity-matched approach to adjust for the selection bias across antipsychotics within the multivariable context of the Andersen Behavioral Model. Cox proportional hazards regression model stratified on matched pairs was used to evaluate the safety profile of antipsychotics in PD. Results: There were 13,352 patients aged 65 years or older with PD diagnosis and without schizophrenia/ bipolar disorder who started one atypical antipsychotic agent in 2008-2009. The incidence of atypical antipsychotic use was 17.50% in 2-year follow-up. The most frequently used inappropriate antipsychotics were risperidone (22.95%) and olanzapine (11.25%). The likelihood of inappropriate antipsychotic use was higher for patients who had dementia or Chronic Obstructive Pulmonary Disease (COPD). Conversely, patients who were taking levodopa, dopamine agonists, Catechol-O-methyltransferase (COMT) inhibitors, Monoamine Oxidase (MAO) inhibitors type B, or amantadine were less likely to receive inappropriate antipsychotics. For the second and third objectives, the analysis involved 6-month washout and follow-up periods. There were 12,076 patients in the matched propensity score cohort. The Hazard Ratio (HR) of pneumonia was 1.23 (95% CI: 1.10 – 1.36) and the HR of all-cause-mortality was 1.13 (95% CI: 1.01 - 1.28) for patients who used inappropriate vs. appropriate atypical antipsychotics. There was a significant association between pneumonia and death. Conclusions: More than one-third of PD patients received… Advisors/Committee Members: Aparasu, Rajender R. (advisor), Johnson, Michael L. (committee member), Chen, Hua (committee member), Sherer, Jeffrey T. (committee member), Holmes, Holly M. (committee member).

Subjects/Keywords: Parkinson's Disease; Antipsychotic Agents; Pneumonia

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APA (6^th Edition):

Chekani, F. (n.d.). Safety of Atypical Antipsychotics in the Elderly with Parkinson’s Disease. (Doctoral Dissertation). University of Houston. Retrieved from http://hdl.handle.net/10657/2662

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Chicago Manual of Style (16^th Edition):

Chekani, Farid. “Safety of Atypical Antipsychotics in the Elderly with Parkinson’s Disease.” Doctoral Dissertation, University of Houston. Accessed April 20, 2021. http://hdl.handle.net/10657/2662.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

MLA Handbook (7^th Edition):

Chekani, Farid. “Safety of Atypical Antipsychotics in the Elderly with Parkinson’s Disease.” Web. 20 Apr 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Chekani F. Safety of Atypical Antipsychotics in the Elderly with Parkinson’s Disease. [Internet] [Doctoral dissertation]. University of Houston; [cited 2021 Apr 20]. Available from: http://hdl.handle.net/10657/2662.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Council of Science Editors:

Chekani F. Safety of Atypical Antipsychotics in the Elderly with Parkinson’s Disease. [Doctoral Dissertation]. University of Houston; Available from: http://hdl.handle.net/10657/2662

Note: this citation may be lacking information needed for this citation format:
No year of publication.

University of Illinois – Chicago

2. Xing, Shan. Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes.

Degree: 2017, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/22207

► This dissertation evaluated the use of and comparative effects of second generation antipsychotics (SGAs) and non-SGA depression pharmacotherapies [bupropion, lithium, mirtazapine, tricyclic antidepressants (TCAs) and… (more)

▼ This dissertation evaluated the use of and comparative effects of second generation antipsychotics (SGAs) and non-SGA depression pharmacotherapies [bupropion, lithium, mirtazapine, tricyclic antidepressants (TCAs) and thyroid hormone] on diabetes outcomes in patients with pre-existing diabetes and depression who previously used a selective serotonin reuptake inhibitor or selective norepinephrine reuptake inhibitor. Three clinical studies compared 1) non-adherence and non-persistence to SGA versus non-SGA depression therapies, 2) non-adherence and non-persistence to oral antidiabetic drugs (OAD) between SGA and non-SGA users, and 3) SGA and non-SGA users on the risk of diabetes-related hospitalization or diabetes drug intensification. Use of SGAs was associated with a 1.8 times higher odds of non-adherence and a 1.4 times higher risk of non-persistence to therapy compared to non-SGA use. Also, SGA users had a 30-40% higher odds of a 10% or greater decline in OAD adherence compared to non-SGA users, while persistence to OAD therapy was similar between groups. Risk of diabetes of diabetes-related hospitalization or diabetes drug intensification was no different comparing SGA versus non-SGA users; however, there were differences when comparing specific treatment subgroups: bupropion was associated with a 15% reduced risk of diabetes-related hospitalization or treatment intensification compared to TCAs, quetiapine was associated with a 18% reduced risk of events compared to mirtazapine, and quetiapine was associated with a 16% reduced risk of events compared to TCAs. Differences for other subgroup comparisons between aripiprazole, quetiapine, bupropion, mirtazapine and TCAs were small and non-significant. Future studies are needed to access the impact of SGA and non-SGA therapies on other diabetes outcomes, including hemoglobin A1c, diabetic complications, and mortality. A fourth methodological study assessed the performance of full-cohort high dimensional propensity score (HDPS) matching approaches versus subgroup-specific HDPS approaches. The full-cohort HDPS matching approaches sometimes resulted in non-overlapping propensity score distributions, more imbalance in potential confounders, and greater than 10% change in effect estimates compared to the subgroup-specific approach. Therefore, examining covariate balance after matching to ensure that patient subgroups are balanced with respect to potential confounders is recommended if one of the full-cohort HDPS approaches are used. Advisors/Committee Members: Lee, Todd A (advisor), Calip, Gregory S (committee member), Leow, Alex D (committee member), Kim, Shiyun (committee member), Schumock, Glen T (committee member), Touchette, Daniel R (committee member), Lee, Todd A (chair).

Subjects/Keywords: Antipsychotic Agents High dimensional propensity score Depression Diabetes Comorbidity Pharmacoepidemiology

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APA (6^th Edition):

Xing, S. (2017). Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/22207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Xing, Shan. “Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes.” 2017. Thesis, University of Illinois – Chicago. Accessed April 20, 2021. http://hdl.handle.net/10027/22207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Xing, Shan. “Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes.” 2017. Web. 20 Apr 2021.

Vancouver:

Xing S. Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes. [Internet] [Thesis]. University of Illinois – Chicago; 2017. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/10027/22207.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Xing S. Second Generation Antipsychotics and Diabetes Outcomes in Patients with Depression and Diabetes. [Thesis]. University of Illinois – Chicago; 2017. Available from: http://hdl.handle.net/10027/22207

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

3. Amato, Isabel de Andrade, 1987-. Fatores clínicos e metabólicos relacionados com ganho de peso em pacientes com transtornos do espectro da esquizofrenia em uso de antipsicóticos atípicos.

Degree: Faculdade de Ciências Médicas; Programa de Pós-Graduação em Ciências Médicas, 2016, Universidade Estadual de Campinas

URL: AMATO, Isabel de Andrade. Fatores clínicos e metabólicos relacionados com ganho de peso em pacientes com transtornos do espectro da esquizofrenia em uso de antipsicóticos atípicos. 2016. 1 recurso online (121 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/321042>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/321042

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Orientador: Paulo Dalgalarrondo

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2018-08-31T14:07:23Z (GMT). No. of bitstreams: 1… (more)

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Orientador: Paulo Dalgalarrondo

Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2018-08-31T14:07:23Z (GMT). No. of bitstreams: 1 Amato_IsabeldeAndrade_M.pdf: 2524438 bytes, checksum: 43b9581bd351eca7e4d688e10f6d57e5 (MD5) Previous issue date: 2016

Resumo: Os antipsicóticos atípicos são, atualmente, o pilar para a terapêutica medicamentosa dos transtornos psicóticos do espectro da esquizofrenia. Entretanto, é frequente a ocorrência de efeitos adversos metabólicos, dentre eles o ganho de peso e suas complicações. A gênese do ganho de peso secundário ao uso de antipsicóticos ainda não está bem estabelecida, mas há indícios da influência de fatores relacionados ao controle de apetite e saciedade e de fatores inflamatórios. Objetivos: descrever aspectos sintomatológicos de pacientes com transtornos do espectro da esquizofrenia em uso de risperidona, olanzapina ou clozapina; verificar possíveis diferenças nas concentrações de adipocinas e marcadores inflamatórios entre os pacientes que ganharam ou não peso; avaliar qualidade de vida, autoimagem corporal, compulsão alimentar e sua possível associação com ganho ponderal. Método: Estudo transversal, realizado no ambulatório de psicóticos e egressos do Hospital das Clínicas da Universidade Estadual de Campinas (HC ¿ UNICAMP), durante o período de março de 2014 a junho de 2015. Os pacientes que participaram do estudo foram divididos em dois grupos, os que ganharam peso e os que não ganharam peso com uso de antipsicóticos. Eles responderam um questionário sociodemográfico e os seguintes instrumentos: Escala para Avaliação da Sintomatologia Psicótica ¿ PANSS, Escala de compulsão alimentar periódica ¿ Binge eating scale, Escala adaptada de Imagem Corporal, Escala de qualidade de vida em esquizofrênicos ¿ QLS-BR e Questionário Internacional de Atividade Física ¿ IPAQ. Foram dosadas as seguintes adipocinas: TNF?, IL1?, IL6, IL10, adiponectina e leptina. Foi realizada a bioimpedância de tais pacientes, além do cálculo de IMC. Resultados: Foram incluídos no estudo 52 sujeitos, dos quais 29 (55,8%) não ganharam peso e 23 (44,2%) ganharam peso. Após o uso da medicação 16 (30,8%) dos sujeitos estavam eutróficos, 25 (48,15%) com sobrepeso e 10 (19,2%) obesos. Os indivíduos eram em sua maioria homens (37 - 71,2%) e a média de idade foi 33,79 + 12,0 anos (IC 95%- 30,45- 37,13). As variáveis que se associaram negativamente com o ganho de peso foram: tempo de uso de medicação, tempo de doença, uso de clozapina e adiponectina. Escolaridade do chefe da família, binge eating, qualidade de vida, qualidade das relações familiares e concentrações de leptina foram mais elevadas entre os que ganharam peso. Conclusões: Concentrações mais elevadas de leptina e menores de adiponectina se associaram significativamente com ganho de peso. Outros fatores inflamatórios, assim como atividade física, não apresentaram tal associação. Ao contrário do esperado, pacientes com maior ganho de peso pontuaram melhor em qualidade de vida e…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Dalgalarrondo, Paulo, 1960-, Noto, Cristiano de Souza, Azevedo, Renata Cruz Soares de.

Subjects/Keywords: Antipsicóticos; Ganho de peso; Esquizofrenia; Antipsychotic agents; Weight gain; Schizophrenia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Amato, Isabel de Andrade, 1. (2016). Fatores clínicos e metabólicos relacionados com ganho de peso em pacientes com transtornos do espectro da esquizofrenia em uso de antipsicóticos atípicos. (Masters Thesis). Universidade Estadual de Campinas. Retrieved from AMATO, Isabel de Andrade. Fatores clínicos e metabólicos relacionados com ganho de peso em pacientes com transtornos do espectro da esquizofrenia em uso de antipsicóticos atípicos. 2016. 1 recurso online (121 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/321042>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/321042

Chicago Manual of Style (16^th Edition):

Amato, Isabel de Andrade, 1987-. “Fatores clínicos e metabólicos relacionados com ganho de peso em pacientes com transtornos do espectro da esquizofrenia em uso de antipsicóticos atípicos.” 2016. Masters Thesis, Universidade Estadual de Campinas. Accessed April 20, 2021. AMATO, Isabel de Andrade. Fatores clínicos e metabólicos relacionados com ganho de peso em pacientes com transtornos do espectro da esquizofrenia em uso de antipsicóticos atípicos. 2016. 1 recurso online (121 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/321042>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/321042.

MLA Handbook (7^th Edition):

Amato, Isabel de Andrade, 1987-. “Fatores clínicos e metabólicos relacionados com ganho de peso em pacientes com transtornos do espectro da esquizofrenia em uso de antipsicóticos atípicos.” 2016. Web. 20 Apr 2021.

Vancouver:

Amato, Isabel de Andrade 1. Fatores clínicos e metabólicos relacionados com ganho de peso em pacientes com transtornos do espectro da esquizofrenia em uso de antipsicóticos atípicos. [Internet] [Masters thesis]. Universidade Estadual de Campinas; 2016. [cited 2021 Apr 20]. Available from: AMATO, Isabel de Andrade. Fatores clínicos e metabólicos relacionados com ganho de peso em pacientes com transtornos do espectro da esquizofrenia em uso de antipsicóticos atípicos. 2016. 1 recurso online (121 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/321042>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/321042.

Council of Science Editors:

Amato, Isabel de Andrade 1. Fatores clínicos e metabólicos relacionados com ganho de peso em pacientes com transtornos do espectro da esquizofrenia em uso de antipsicóticos atípicos. [Masters Thesis]. Universidade Estadual de Campinas; 2016. Available from: AMATO, Isabel de Andrade. Fatores clínicos e metabólicos relacionados com ganho de peso em pacientes com transtornos do espectro da esquizofrenia em uso de antipsicóticos atípicos. 2016. 1 recurso online (121 p.). Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/321042>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/321042

University of Alberta

4. Bresee, Lauren. Mental health and chronic medical conditions: schizophrenia, its treatment, risk of metabolic complications, and health care utilization.

Degree: PhD, School of Public Health, 2010, University of Alberta

URL: https://era.library.ualberta.ca/files/gb19f584t

► Objective - To assess the relationship between schizophrenia and cardiovascular disease by evaluating metabolic risk associated with treatment for schizophrenia, prevalence of cardiovascular risk factors… (more)

▼ Objective - To assess the relationship between schizophrenia and cardiovascular disease by evaluating metabolic risk associated with treatment for schizophrenia, prevalence of cardiovascular risk factors (CV-RF) and disease (CV-D), and health care utilization in people with schizophrenia compared to the non-schizophrenic population. Methods – Four studies were completed to evaluate the dissertation objectives. A systematic review was completed to quantify the change in metabolic parameters associated with use of atypical antipsychotic agents. The second study utilized a period prevalence design to compare prevalence of CV-RF (diabetes, hypertension, dyslipidemia) and CV-D in people with and without schizophrenia using the administrative databases of Alberta Health and Wellness. General and cardiac specialist health care utilization was evaluated in people with schizophrenia using data from Alberta Health and Wellness. Lastly, results from the Canadian Community Health Survey were used to evaluate prevalence of CV-RF and CV-D while controlling for important lifestyle and demographic variables unavailable in the databases of Alberta Health and Wellness. Results – Use of atypical agents, particularly clozapine, resulted in statistically significant weight gain and increases in total cholesterol and blood glucose compared to typical agents. Having schizophrenia was associated with a significantly higher prevalence of diabetes, obesity, smoking, and CV-D compared to people without schizophrenia. Individuals with schizophrenia visited a general practitioner and the emergency department more often, and were more likely to be hospitalized than those without schizophrenia. Despite having a higher prevalence of coronary artery disease, individuals with schizophrenia were significantly less likely to visit a cardiologist or undergo revascularization compared to people with coronary artery disease who did not have schizophrenia. Conclusion – Individuals with schizophrenia have a considerable burden of cardiovascular disease compared to people without schizophrenia. This is likely a result of a number of factors, including medications used to treat schizophrenia, the increased prevalence of smoking and other unhealthy lifestyle factors, and the increased prevalence of cardiovascular risk factors in people with schizophrenia. Individuals with schizophrenia utilize the general health care system more frequently than their non-schizophrenic counterparts, therefore the opportunity exists for monitoring for and management of modifiable cardiovascular risk factors in this vulnerable population.

Subjects/Keywords: atypical antipsychotic agents; type 2 diabetes; cardiovascular disease; health care utilization; schizophrenia

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APA (6^th Edition):

Bresee, L. (2010). Mental health and chronic medical conditions: schizophrenia, its treatment, risk of metabolic complications, and health care utilization. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/gb19f584t

Chicago Manual of Style (16^th Edition):

Bresee, Lauren. “Mental health and chronic medical conditions: schizophrenia, its treatment, risk of metabolic complications, and health care utilization.” 2010. Doctoral Dissertation, University of Alberta. Accessed April 20, 2021. https://era.library.ualberta.ca/files/gb19f584t.

MLA Handbook (7^th Edition):

Bresee, Lauren. “Mental health and chronic medical conditions: schizophrenia, its treatment, risk of metabolic complications, and health care utilization.” 2010. Web. 20 Apr 2021.

Vancouver:

Bresee L. Mental health and chronic medical conditions: schizophrenia, its treatment, risk of metabolic complications, and health care utilization. [Internet] [Doctoral dissertation]. University of Alberta; 2010. [cited 2021 Apr 20]. Available from: https://era.library.ualberta.ca/files/gb19f584t.

Council of Science Editors:

Bresee L. Mental health and chronic medical conditions: schizophrenia, its treatment, risk of metabolic complications, and health care utilization. [Doctoral Dissertation]. University of Alberta; 2010. Available from: https://era.library.ualberta.ca/files/gb19f584t

University of Saskatchewan

5. Luo, Jiang Ping. Pharmacokinetic studies of fluphenazine and four ester prodrugs.

Degree: 1999, University of Saskatchewan

URL: http://hdl.handle.net/10388/etd-10212004-002057

► The purpose of present thesis work was to investigate the pharmacokinetics of FLU and four aliphatic esters, FLU-A, FLU-B, FLU-E and FLU-D, and in particular,… (more)

▼ The purpose of present thesis work was to investigate the pharmacokinetics of FLU and four aliphatic esters, FLU-A, FLU-B, FLU-E and FLU-D, and in particular, the impact of the ester groups on the pharmacokinetics of the parent compound FLU after administration of the prodrugs in oil based injections. It was determined that the sesame oil/buffer partition coefficients (PC) decreased as the homogenous series of the ester chain length was increased, the effect of the chain length of the prodrug on the release rate of the corresponding prodrug from the oily depot. Furthermore, the results from 'in vitro ' enzymatic experiments using plasma, liver and muscle homogenates obtained from dog or human showed that lipophilicity of the esters predominated over other parameters such as enzymatic hydrolysis in determining the sustained production of FLU when the prodrugs were given as oil based intramuscular depot formulations. The roles of depot injection sites and proximal lymph nodes in the absorption kinetics of FLUand prodrug were investigated by intramuscular administration of either FLU base or FLU-D in sesame oil to groups of rats. The quantitative data suggested the involvement of the lymphatic system in the presystemic absorption of FLU and FLU-D after intramuscular administration of FLU-D in sesame oil. Finally, intravenous or intramuscular pharmacokinetics of FLU and four esters were investigated in dogs. The results showed that the chain length affected the kinetics of both FLU and the ester prodrugs. A pharmacokinetic model (s) was developed to simulate the disposition of FLU-D and the formation of FLU after either intravenous or intramuscular administration of FLU-D. Satisfactory fits of the simulated profiles with the observed data implies that the prolonged elimination profiles of FLU observed after intravenous administration could be rate limited by the ester chain length dependent distribution or redistribution of the prodrug from poorly perfused (fatty) deep compartments and subsequent hydrolysis in more highly perfused tissues while the ultimate rate limiting step in the absorption kinetics of FLU and prodrug after intramuscular administration could be the slow partitioning out of prodrug from the oily deposits at the injection sites and surrounding tissues such as proximal lymph nodes with the subsequent hydrolysis of the ester group in the body. Advisors/Committee Members: Hubbard, John.

Subjects/Keywords: medicine; pharmacy; drugs; metabolism; antipsychotic agents

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APA (6^th Edition):

Luo, J. P. (1999). Pharmacokinetic studies of fluphenazine and four ester prodrugs. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/etd-10212004-002057

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Luo, Jiang Ping. “Pharmacokinetic studies of fluphenazine and four ester prodrugs.” 1999. Thesis, University of Saskatchewan. Accessed April 20, 2021. http://hdl.handle.net/10388/etd-10212004-002057.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Luo, Jiang Ping. “Pharmacokinetic studies of fluphenazine and four ester prodrugs.” 1999. Web. 20 Apr 2021.

Vancouver:

Luo JP. Pharmacokinetic studies of fluphenazine and four ester prodrugs. [Internet] [Thesis]. University of Saskatchewan; 1999. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/10388/etd-10212004-002057.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Luo JP. Pharmacokinetic studies of fluphenazine and four ester prodrugs. [Thesis]. University of Saskatchewan; 1999. Available from: http://hdl.handle.net/10388/etd-10212004-002057

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Knežević Vladimir. Agresivnost i hostilnost u strukturi i lečenju shizofrenih poremećaja.

Degree: 2015, University of Novi Sad

URL: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija141199576575487.pdf?controlNumber=(BISIS)90304&fileName=141199576575487.pdf&id=2719&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=90304&source=OATD&language=en

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Cilj: U istraživanju je posmatrana učestalost agresivnosti i hostilnosti kod osoba sa shizofrenim poremećajem, zatim povezanost težine kliniĉke slike shizofrenog poremećaja sa pojavom i… (more)

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Cilj: U istraživanju je posmatrana učestalost agresivnosti i hostilnosti kod osoba sa shizofrenim poremećajem, zatim povezanost težine kliniĉke slike shizofrenog poremećaja sa pojavom i stepenom agresivnosti i hostilnosti, povezanost doze ordiniranih antipsihotika sa stepenom agresivnosti i hostilnosti, kao i razlika u specifiĉnoj antiagresivnoj i antihostilnoj efikasnosti između risperidona i klozapina. Materijal i metode: Ova opservaciona studija je uključila 110 hospitalno lečenih bolesnika sa dijagnozom shizofrenog poremećaja koji su na prijemu u bolnicu imali vrednost ajtema P7 (hostilnost) skale PANSS ≥ 3 i vrednost skale MOAS ≥ 3. Bolesnici su procenjivani skalama PANSS i MOAS svakih sedam dana tokom njihovog bolničkog lečenja. Rezultati: Hostilnost i agresivnost su kao simptomi prisutni kod jedne trećine bolesnika sa dijagnozom shizofrenog poremećaja, a intenziteti hostilnosti i agresivnosti nisu povezani sa težinom kliničke slike poremećaja. Visine doza inicijalno ordiniranih antipsihotika su upravo srazmerne stepenu hostilnosti i agresivnosti bolesnika. Utvrđeno je da postoji specifično antiagresivno i antihostilno dejstvo i klozapina i risperidona, koje je nezavisno od njihovog antipsihotičnog dejstva, a klozapin je tokom posmatranog perioda imao bolju antihostilnu efikasnost. Zaključak: Agresivnost i hostilnost predstavljaju često prisutnu, značajnu, ali nezavisnu dimenziju shizofrenog poremećaja, a izbor antipsihotika se pored antipsihotične efikasnosti mora zasnivati i na njihovoj specifičnoj antiagresivnoj efikasnosti.

Objective: Frequency of aggression and hostility was observed in patients with schizophrenia, as well as the connection of symptom’s severity with the appearance and level of aggression and hostility. The connection between the applied doses of antipsychotics with the level of aggression and hostility was observed, as well as differences in the specific antiagressive and antihostile efficacy of risperidone and clozapine. Materials and Methods: This observational study involved 110 hospitalized patients diagnosed with schizophrenia who had scores ≥ 3 on item P7 (hostility) of PANSS scale and score ≥ 3 on MOAS scale. Patients were evaluated every seven days during their hospitalization. Results: Hostility and aggression were present in one-third of schizophrenic patients on their hospital admission and their intensity was not related to the severity of the symptoms of schizophrenia. The dose of initially administered antipsychotics was proportional to the level of patient’s hostility and aggression. It has been found that there is a specific antiaggressive and antihostile efficacy of clozapine and risperidone, which is independent of their antipsychotic efficacy, and that clozapine has a better antihostile efficacy during the observed period. Conclusion: Aggression and hostility are often present, important, but an independent dimension of schizophrenia, and the selection of antipsychotic must be based on it’s specific antiaggressive efficacy, in…

Advisors/Committee Members: Mitrović Dragan, Drezgić-Vukić Svetlana, Siladji-Mladenovic Djendji, Nedić Aleksandra, Živanović Olga, Novović Zdenka.

Subjects/Keywords: Shizofrenija; Agresija; Antipsihotični agensi; Klozapin; Risperidon; Schizophrenia; Aggression; Antipsychotic Agents; Clozapine; Risperidone

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vladimir, K. (2015). Agresivnost i hostilnost u strukturi i lečenju shizofrenih poremećaja. (Thesis). University of Novi Sad. Retrieved from https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija141199576575487.pdf?controlNumber=(BISIS)90304&fileName=141199576575487.pdf&id=2719&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=90304&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vladimir, Knežević. “Agresivnost i hostilnost u strukturi i lečenju shizofrenih poremećaja.” 2015. Thesis, University of Novi Sad. Accessed April 20, 2021. https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija141199576575487.pdf?controlNumber=(BISIS)90304&fileName=141199576575487.pdf&id=2719&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=90304&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vladimir, Knežević. “Agresivnost i hostilnost u strukturi i lečenju shizofrenih poremećaja.” 2015. Web. 20 Apr 2021.

Vancouver:

Vladimir K. Agresivnost i hostilnost u strukturi i lečenju shizofrenih poremećaja. [Internet] [Thesis]. University of Novi Sad; 2015. [cited 2021 Apr 20]. Available from: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija141199576575487.pdf?controlNumber=(BISIS)90304&fileName=141199576575487.pdf&id=2719&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=90304&source=OATD&language=en.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vladimir K. Agresivnost i hostilnost u strukturi i lečenju shizofrenih poremećaja. [Thesis]. University of Novi Sad; 2015. Available from: https://www.cris.uns.ac.rs/DownloadFileServlet/Disertacija141199576575487.pdf?controlNumber=(BISIS)90304&fileName=141199576575487.pdf&id=2719&source=OATD&language=en ; https://www.cris.uns.ac.rs/record.jsf?recordId=90304&source=OATD&language=en

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

7. Mittestainer, Francine Cappa, 1986-. Efeito dos antipsicóticos olanzapina e clozapina nos parâmetros metabólicos e na microbiota intestinal de camundongos.

Degree: Faculdade de Ciências Médicas; Programa de Pós-Graduação em Fisiopatologia Médica, 2016, Universidade Estadual de Campinas

URL: MITTESTAINER, Francine Cappa. Efeito dos antipsicóticos olanzapina e clozapina nos parâmetros metabólicos e na microbiota intestinal de camundongos. 2016. 1 recurso online (91 p.). Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/319200>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/319200

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Orientador: Mario Jose Abdalla Saad

Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

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Orientador: Mario Jose Abdalla Saad

Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas

Made available in DSpace on 2018-08-31T05:47:54Z (GMT). No. of bitstreams: 1 Mittestainer_FrancineCappa_D.pdf: 4695852 bytes, checksum: a3b6c9cefccbcc78d00982c41bbceab2 (MD5) Previous issue date: 2016

Resumo: Os antipsicóticos atípicos representam a base do tratamento da esquizofrenia e, esses fármacos estão associados a sérios distúrbios metabólicos como; ganho de peso, doenças cardiovasculares, a hiperglicemia, resistência à insulina e diabetes. Nos últimos anos, a microbiota intestinal tem sido alvo de inúmeros estudos, pois ela pode desempenhar um papel importante no desencadeamento dessas doenças. Assim, com base nas evidências, sobre o desenvolvimento de resistência à insulina dos pacientes com esquizofrenia que usam esses medicamentos o objetivo do trabalho foi investigar, as possíveis alterações, metabólicas e na composição da microbiota intestinal, causadas pelo tratamento dos antipsicóticos olanzapina e clozapina em camundongos. Para o experimento, foram usados camundongos machos C57BL/6 composto aleatoriamente de três grupos diferentes. O primeiro grupo, controle, foi alimentado com dieta padrão e tratados com veículo. O segundo grupo, olanza, os animais também foram alimentados com dieta padrão e tratados com o antipsicótico olanzapina (1mg/kg/dia). O terceiro grupo, cloza, os animais foram alimentados com dieta padrão e tratados com antipsicótico clozapina (10mg/kg/dia). O tratamento com os antipsicóticos foram administradas por via oral (gavagem) por 30 dias. Nossos resultados mostraram que o tratamento com olanzapina e clozapina induziu o desenvolvimento intolerância à glicose e insulina, independentemente do ganho de peso nos animais estudados. Além disso, os dados demonstraram que as drogas diminuíram a sensibilidade à insulina nos tecidos periféricos como fígado, músculo e tecido adiposo causando a resistência à insulina. Para investigar o efeito da olanzapina e clozapina na microbiota intestinal, analisamos as bactérias presentes no intestino grosso. E observamos que a composição da microbiota nesses animais estavam alteradas, principalmente, em nível de gêneros. Realizamos o transplante de microbiota intestinal para confirmar se a microbiota intestinal era a responsável por induzir o desenvolvimento da resistência à insulina nos animais tratados com olanzapina e clozapina. Observamos que a resistência à insulina encontrada nos animais tratados não foi reproduzida pelo transplante de microbiota intestinal. Assim podemos concluir que, por um período de 30 dias, o tratamento com os antipsicóticos olanzapina e clozapina nos mostrou ter uma ação direta sobre as vias metabólicas, acentuando a intolerância à glicose e a resistência à insulina, independentemente da modulação da microbiota intestinal nos animais estudados. Vimos também que a administração dos fármacos estimulou a ativação da via da mTOR o que pode contribuir para o desenvolvimento da resistência à insulina e…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Saad, Mario José Abdalla, 1956-, Araújo, Raquel Silva, Roman, Erika Anne de Freitas Robles, Leal, Raquel Franco, Carvalho, Carla Roberta de Oliveira.

Subjects/Keywords: Antipsicóticos; Resistência à insulina; Microbioma gastrointestinal; Antipsychotic agents; Insulin resistance; Gastrointestinal microbiome

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mittestainer, Francine Cappa, 1. (2016). Efeito dos antipsicóticos olanzapina e clozapina nos parâmetros metabólicos e na microbiota intestinal de camundongos. (Doctoral Dissertation). Universidade Estadual de Campinas. Retrieved from MITTESTAINER, Francine Cappa. Efeito dos antipsicóticos olanzapina e clozapina nos parâmetros metabólicos e na microbiota intestinal de camundongos. 2016. 1 recurso online (91 p.). Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/319200>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/319200

Chicago Manual of Style (16^th Edition):

Mittestainer, Francine Cappa, 1986-. “Efeito dos antipsicóticos olanzapina e clozapina nos parâmetros metabólicos e na microbiota intestinal de camundongos.” 2016. Doctoral Dissertation, Universidade Estadual de Campinas. Accessed April 20, 2021. MITTESTAINER, Francine Cappa. Efeito dos antipsicóticos olanzapina e clozapina nos parâmetros metabólicos e na microbiota intestinal de camundongos. 2016. 1 recurso online (91 p.). Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/319200>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/319200.

MLA Handbook (7^th Edition):

Mittestainer, Francine Cappa, 1986-. “Efeito dos antipsicóticos olanzapina e clozapina nos parâmetros metabólicos e na microbiota intestinal de camundongos.” 2016. Web. 20 Apr 2021.

Vancouver:

Mittestainer, Francine Cappa 1. Efeito dos antipsicóticos olanzapina e clozapina nos parâmetros metabólicos e na microbiota intestinal de camundongos. [Internet] [Doctoral dissertation]. Universidade Estadual de Campinas; 2016. [cited 2021 Apr 20]. Available from: MITTESTAINER, Francine Cappa. Efeito dos antipsicóticos olanzapina e clozapina nos parâmetros metabólicos e na microbiota intestinal de camundongos. 2016. 1 recurso online (91 p.). Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/319200>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/319200.

Council of Science Editors:

Mittestainer, Francine Cappa 1. Efeito dos antipsicóticos olanzapina e clozapina nos parâmetros metabólicos e na microbiota intestinal de camundongos. [Doctoral Dissertation]. Universidade Estadual de Campinas; 2016. Available from: MITTESTAINER, Francine Cappa. Efeito dos antipsicóticos olanzapina e clozapina nos parâmetros metabólicos e na microbiota intestinal de camundongos. 2016. 1 recurso online (91 p.). Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Campinas, SP. Disponível em: <http://www.repositorio.unicamp.br/handle/REPOSIP/319200>. Acesso em: 31 ago. 2018. ; http://repositorio.unicamp.br/jspui/handle/REPOSIP/319200

Freie Universität Berlin

8. Sickert, Laertes. Genetics of antipsychotic drug-induced weight gain within the noradrenergic system at patients suffering from schizophrenic disorders.

Degree: 2010, Freie Universität Berlin

URL: https://refubium.fu-berlin.de/handle/fub188/12364

► Antipsychotic-induced weight gain has developed into a severe side effect with the growing use of new so-called atypical antipsychotics (AP) in the pharmacological treatment of… (more)

▼ Antipsychotic-induced weight gain has developed into a severe side effect with the growing use of new so-called atypical antipsychotics (AP) in the pharmacological treatment of schizophrenia. Consequences of resulting obesity are increased morbidity and mortality as well as an additional stigma for the mentally ill. In recent times increasing search for genetic co-factors aims to help explaining the inter-individual side effect profiles. The noradrenergic system possibly holds an important role. Other studies already investigated candidate genes, but until now there has been no comprehensive analysis of the different genes involved in metabolism and receptor level of the noradrenergic system. Genes in focus are those translating for adrenergic receptors (AR) and those that affect blood or CSF concentrations of noradrenaline (NA). A prospective multicenter association study at psychiatric clinics in the U.S. recruited 140 schizophrenic and schizoaffective patients. Weight change was determined over an average of eight weeks after taking AP. The aim of our study was to investigate the influence of the noradrenergic system on the AP- induced weight gain in relation to the AR genes ADRA1A, ADRA2A, ADRA2C, ADRB3 and the genes DBH, MAOA and COMT which influence NA concentration in the synaptic cleft. ADRA2C and the NA metabolism genes DBH, MAOA and COMT showed no associations. In contrast patients carrying the ADRA1A gene Cys347 allele, the ADRA2A gene C-1291 allele and patients of European origin carrying the ADRB3 gene Arg64 allele showed increased AP-induced weight gain. Additionally, for the first time the combined analysis of polymorphisms found at least statistically significant evidence for epistatic effects between ADRA1A and DBH, as well as ADRA1C and COMT. The presumable interaction of AR and metabolic genes suggest a complex polygenic dysregulation of the noradrenergic system in the AP-induced weight gain. Not primarily genetic influence was also considered within the present study showing a significant influence of ethnicity. Despite mostly negative results we could determine different genes of the noradrenergic system and therein most possibly certain subgroups to be involved in AP-induced weight gain. For example, it was reported in two studies with Asian patients that a promoter variant (-1291C / G) of the ADRA2A gene is associated with AP-induced weight gain. This work now also showed a significant association in Europeans, however not in African-Americans. For a more detailed analysis however, further studies in larger populations are required. Our work suggests that the noradrenergic system holds an important role in AP-induced weight gain, so further research should be encouraged. Advisors/Committee Members: m (gender), Prof. Dr. med. J. Gallinat (firstReferee), Prof. Dr. M. Dettling (furtherReferee), Priv.-Doz. Dr. med. K. Domschke (furtherReferee).

Subjects/Keywords: genetics; noradrenergic system; weight gain; antipsychotic drugs; neuroleptic agents; 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sickert, L. (2010). Genetics of antipsychotic drug-induced weight gain within the noradrenergic system at patients suffering from schizophrenic disorders. (Thesis). Freie Universität Berlin. Retrieved from https://refubium.fu-berlin.de/handle/fub188/12364

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sickert, Laertes. “Genetics of antipsychotic drug-induced weight gain within the noradrenergic system at patients suffering from schizophrenic disorders.” 2010. Thesis, Freie Universität Berlin. Accessed April 20, 2021. https://refubium.fu-berlin.de/handle/fub188/12364.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sickert, Laertes. “Genetics of antipsychotic drug-induced weight gain within the noradrenergic system at patients suffering from schizophrenic disorders.” 2010. Web. 20 Apr 2021.

Vancouver:

Sickert L. Genetics of antipsychotic drug-induced weight gain within the noradrenergic system at patients suffering from schizophrenic disorders. [Internet] [Thesis]. Freie Universität Berlin; 2010. [cited 2021 Apr 20]. Available from: https://refubium.fu-berlin.de/handle/fub188/12364.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sickert L. Genetics of antipsychotic drug-induced weight gain within the noradrenergic system at patients suffering from schizophrenic disorders. [Thesis]. Freie Universität Berlin; 2010. Available from: https://refubium.fu-berlin.de/handle/fub188/12364

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Bradford

9. Rajagopal, Lakshmi. Neonatal phencyclidine (PCP) induced deficits in rats : a behavioural investigation of relevance to schizophrenia.

Degree: PhD, 2011, University of Bradford

URL: http://hdl.handle.net/10454/5404

► Background: The main aim of the studies in this thesis is to provide insights into the neonatal phencyclidine (PCP) induced deficits in male and female… (more)

▼ Background: The main aim of the studies in this thesis is to provide insights into the neonatal phencyclidine (PCP) induced deficits in male and female rats as a neurodevelopmental animal model of schizophrenia. Methods: Both male and female rats were treated with neonatal PCP on postnatal days (PNDs) 7,9 and 11 or vehicle, followed by weaning on PND 21-22. The rats were then tested in behavioural paradigms such as novel object recognition, spatial memory and social interaction in their adolescent and adult stages and were also tested with acute treatment of typical and atypical antipsychotic agents. Results: Neonatal PCP treatment (10 & 20 mg/kg in males and 10 mg/kg in females; once a day for 3 days on PND 7,9 and 11) caused novel object recognition and spatial memory impairment in male and female rats both in the adolescent (PND35-56) and in the adult stages (PND>56) (chapter 2) and robust deficits in social interaction behaviours in the adolescent stage. The SI deficits were observed in adulthood in female but not in male rats thereby establishing a sex-specific social behavioural deficit (chapter 3). The object memory and social interaction deficits induced by neonatal PCP treatment were reversed following acute risperidone but not haloperidol. Finally, the temporal profile of this treatment regime was investigated and the male and female animals were tested on PND 190 and PND 365. The animals did not have any challenge dose of PCP during their testing stage. The result showed that there was significant deficit in object and spatial recognition memory in both male and female animals at both time points, thereby establishing enduring deficits. Conclusion: Given the heterogeneity of the schizophrenic disorder and its complex aetiology, it is understandably difficult to find animal models that completely mimic most or all of the symptoms associated with the disorder. However, data from the studies in this thesis support the use of neonatal PCP as a valid animal model of cognitive and negative symptoms, and explores the effect of antipsychotics in understanding the model. Also, in light of the efficacy of neonatal PCP to produce robust object, spatial memory and social interaction deficits in rats, it appears that this model may be a useful tool to investigate the potential of novel therapeutic candidates that may help improve therapy and understand the illness.

Subjects/Keywords: 615.1; Neonatal phencyclidine (PCP); Schizophrenia; Animal model of schizophrenia; Spatial memory; Social interaction; Antipsychotic agents; Rats: animal models

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rajagopal, L. (2011). Neonatal phencyclidine (PCP) induced deficits in rats : a behavioural investigation of relevance to schizophrenia. (Doctoral Dissertation). University of Bradford. Retrieved from http://hdl.handle.net/10454/5404

Chicago Manual of Style (16^th Edition):

Rajagopal, Lakshmi. “Neonatal phencyclidine (PCP) induced deficits in rats : a behavioural investigation of relevance to schizophrenia.” 2011. Doctoral Dissertation, University of Bradford. Accessed April 20, 2021. http://hdl.handle.net/10454/5404.

MLA Handbook (7^th Edition):

Rajagopal, Lakshmi. “Neonatal phencyclidine (PCP) induced deficits in rats : a behavioural investigation of relevance to schizophrenia.” 2011. Web. 20 Apr 2021.

Vancouver:

Rajagopal L. Neonatal phencyclidine (PCP) induced deficits in rats : a behavioural investigation of relevance to schizophrenia. [Internet] [Doctoral dissertation]. University of Bradford; 2011. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/10454/5404.

Council of Science Editors:

Rajagopal L. Neonatal phencyclidine (PCP) induced deficits in rats : a behavioural investigation of relevance to schizophrenia. [Doctoral Dissertation]. University of Bradford; 2011. Available from: http://hdl.handle.net/10454/5404

University of British Columbia

10. Dewey, Kevin John. The effects of dose and duration of neuroleptic administration on dopamine receptor sensitivity.

Degree: MS- MSc, Neuroscience, 1981, University of British Columbia

URL: http://hdl.handle.net/2429/23124

► It is well established that chronic treatment with neuroleptic agents which selectively block dopamine (DA) receptors in the brain leads to the development of DA… (more)

▼ It is well established that chronic treatment with neuroleptic agents which selectively block dopamine (DA) receptors in the brain leads to the development of DA receptor supersensitivity. However comparing the degree and duration of the changes in receptor sensitivity obtained by different investigators has been extremely difficult, because of the numerous differences that exist in individual methods of producing and examining DA receptor supersensitivity. By examining the DA receptor supersensitivity that ensues following chronic treatment with different doses and durations of pimozide, at various intervals after withdrawal from treatment, the overall parametric changes can be more directly compared. To measure the changes in DA receptor sensitivity following chronic pimozide treatment, both behavioral (d.-amphetamine-induced locomotor activity; apomorphine-induced stereotypy) and biochemical (DA receptor binding assay) techniques were utilized. With increasing doses of chronic pimozide treatment, the degree and duration of the resulting DA receptor supersensitivity increased as measured both behaviorally and biochemically. Similarily, the longer durations of chronic pimozide treatment had a greater effect on the degree and duration of the increased DA receptor sensitivity than did the shorter durations of treatment. Correlations were found between the biochemical and behavioral results both between groups of animals treated chronically with different doses and durations of pimozide and within individual groups of animals. In addition, the changes in receptor sensitivity following chronic pimozide treatment was due to an increase in the number of DA receptors with no change in the affinity of these receptors to DA. These results following chronic treatment with neuroleptics demonstrate that the behavioral supersensitivity observed in animals in response to either the direct DA agonist apomorphine or the indirect DA agonist d-amphetamine, may be a result of an increased number of DA receptors. Finally, the supersensitive DA receptors that develop as a result of chronic treatment with neuroleptics are discussed with regard to their possible relevance as an animal model of the iatrogenic disease, tardive dyskinesia, observed clinically in schizophrenic patients withdrawn from neuroleptic therapy.

Subjects/Keywords: Neuropsychopharmacology; Dopamine – Receptors; Antipsychotic Agents; Receptors, Dopamine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dewey, K. J. (1981). The effects of dose and duration of neuroleptic administration on dopamine receptor sensitivity. (Masters Thesis). University of British Columbia. Retrieved from http://hdl.handle.net/2429/23124

Chicago Manual of Style (16^th Edition):

Dewey, Kevin John. “The effects of dose and duration of neuroleptic administration on dopamine receptor sensitivity.” 1981. Masters Thesis, University of British Columbia. Accessed April 20, 2021. http://hdl.handle.net/2429/23124.

MLA Handbook (7^th Edition):

Dewey, Kevin John. “The effects of dose and duration of neuroleptic administration on dopamine receptor sensitivity.” 1981. Web. 20 Apr 2021.

Vancouver:

Dewey KJ. The effects of dose and duration of neuroleptic administration on dopamine receptor sensitivity. [Internet] [Masters thesis]. University of British Columbia; 1981. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/2429/23124.

Council of Science Editors:

Dewey KJ. The effects of dose and duration of neuroleptic administration on dopamine receptor sensitivity. [Masters Thesis]. University of British Columbia; 1981. Available from: http://hdl.handle.net/2429/23124

Universidade Estadual de Campinas

11. Garcia-Rosa, Sheila, 1987-. Investigação do proteoma do plasma sanguíneo associado a resposta clínica de antipsicóticos atípicos em pacientes com esquizofrenia : Investigation of blood plasma proteome associated with clinical response of atypical antipsychotics in patients with schizophrenia.

Degree: Instituto de Biologia; Programa de Pós-Graduação em Biologia Funcional e Molecular, 2019, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342625

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Orientador: Daniel Martins de Souza

Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia

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Orientador: Daniel Martins de Souza

Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia

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Resumo: A esquizofrenia é um transtorno mental debilitante incurável que afeta mais de 21 milhões de indivíduos da população mundial e cerca de 1,6 milhões da população brasileira. Trata-se de uma doença multifatorial que envolve fatores exógenos e endógenos desde o neurodesenvolvimento. A principal maneira de tratar essa doença é através do uso de antipsicóticos que gera um custo em torno de 222 milhões de reais para tratar 81,5% dos pacientes com esquizofrenia no sistema público de saúde do estado de São Paulo. Entretanto, o tratamento para uma parcela considerável dos pacientes com esquizofrenia ainda é ineficaz, sobretudo devido a limitada compreensão dos efeitos dessas drogas em nível molecular e na ausência de biomarcadores preditivos de sua eficiência, ocasionando um grande impacto socioeconômico e na qualidade de vida dos pacientes e de seus familiares. A proteômica é, por definição, uma ferramenta adequada para estudos de doenças complexas, como a esquizofrenia, dada a sua capacidade de identificar, quantificar e caracterizar proteínas sob diferentes condições.Para endereçar essas questões, nosso primeiro objetivo foi entender quais são os mecanismos moleculares envolvidos na sinalização de resposta a antipsicóticos atípicos, através da análise do proteoma do plasma sanguíneo coletados in vivo de pacientes antes e após seis semanas de tratamento com os antipsicóticos olanzapina (n=11) e risperidona (n=15). A partir dessa análise foi possível observar vias de sinalização relacionadas a funções do sistema imune e inflamatório em pacientes que tiveram resposta positiva ao tratamento. Essas proteínas foram principalmente atribuídas a vias de resposta de fase aguda, sistema imune inato, degranulação de neutrófilos, sistema de coagulação, ativação de protrombina, sistema complemento e ativação de LXR/RXR. Além disso, proteínas de resposta de fase aguda, como a alfa 1 antiquimotripsina e o angiotensinogenio têm sido encontradas alteradas em pacientes com esquizofrenia e os antipsicóticos desse estudo parecem ter um papel na regulação dos níveis das mesmas. Esses achados reforçam a hipótese da modulação do sistema imune pelo tratamento com antipsicóticos atípicos. Devido a importância dos marcadores moleculares para a condução de um tratamento eficaz nos estágios iniciais da doença, a segunda proposta dessa tese foi analisar o plasma sanguíneo coletados in vivo de pacientes com esquizofrenia antes do tratamento para identificar possíveis assinaturas proteicas de resposta positiva aos antipsicóticos olanzapina e risperidona de acordo com a eficácia da medicação observada na clínica. Com o objetivo de reduzir o foco nas assinaturas de proteínas de predição de resposta ao tratamento, em vez de vias amplas,…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Martins-de-Souza, Daniel, 1979-, Santos, Lucilene Delazari dos, Calzavara, Mariana Bendlin, Vicentini, Renato, Vieira, Andre Schwambach.

Subjects/Keywords: Esquizofrenia; Proteômica; Plasma sanguíneo; Antipsicóticos; Espectrometria de massa; Schizophrenia; Proteomics; Blood plasma; Antipsychotic agents; Mass spectrometry

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APA (6^th Edition):

Garcia-Rosa, Sheila, 1. (2019). Investigação do proteoma do plasma sanguíneo associado a resposta clínica de antipsicóticos atípicos em pacientes com esquizofrenia : Investigation of blood plasma proteome associated with clinical response of atypical antipsychotics in patients with schizophrenia. (Doctoral Dissertation). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/342625

Chicago Manual of Style (16^th Edition):

Garcia-Rosa, Sheila, 1987-. “Investigação do proteoma do plasma sanguíneo associado a resposta clínica de antipsicóticos atípicos em pacientes com esquizofrenia : Investigation of blood plasma proteome associated with clinical response of atypical antipsychotics in patients with schizophrenia.” 2019. Doctoral Dissertation, Universidade Estadual de Campinas. Accessed April 20, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/342625.

MLA Handbook (7^th Edition):

Garcia-Rosa, Sheila, 1987-. “Investigação do proteoma do plasma sanguíneo associado a resposta clínica de antipsicóticos atípicos em pacientes com esquizofrenia : Investigation of blood plasma proteome associated with clinical response of atypical antipsychotics in patients with schizophrenia.” 2019. Web. 20 Apr 2021.

Vancouver:

Garcia-Rosa, Sheila 1. Investigação do proteoma do plasma sanguíneo associado a resposta clínica de antipsicóticos atípicos em pacientes com esquizofrenia : Investigation of blood plasma proteome associated with clinical response of atypical antipsychotics in patients with schizophrenia. [Internet] [Doctoral dissertation]. Universidade Estadual de Campinas; 2019. [cited 2021 Apr 20]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342625.

Council of Science Editors:

Garcia-Rosa, Sheila 1. Investigação do proteoma do plasma sanguíneo associado a resposta clínica de antipsicóticos atípicos em pacientes com esquizofrenia : Investigation of blood plasma proteome associated with clinical response of atypical antipsychotics in patients with schizophrenia. [Doctoral Dissertation]. Universidade Estadual de Campinas; 2019. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342625

University of Missouri – Kansas City

12. Kriz, Carrie. Variability in Pricing of Generic Antipsychotic Medications Used in the Treatment of Schizophrenia at Community Pharmacies in the Kansas City Metropolitan Area.

Degree: 2018, University of Missouri – Kansas City

URL: http://hdl.handle.net/10355/68866

► Studies examining variability in generic medication pricing at community pharmacies have revealed conflicting results. No studies have examined variability in costs of antipsychotic medications or… (more)

▼ Studies examining variability in generic medication pricing at community pharmacies have revealed conflicting results. No studies have examined variability in costs of antipsychotic medications or if these costs vary across types of pharmacies. Specifically, comparative drug pricing for generic formulations of five commonly used second-generation antipsychotic medications (risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole) recommended for first line therapy in the treatment for schizophrenia is lacking. Pharmacy-level variability in retail cash pricing for five generically available second-generation and one first-generation antipsychotic medications at therapeutic doses for the treatment of schizophrenia in the Kansas City metropolitan area was examined. Two hundred and sixty-five pharmacies were queried by telephone between April 25 and May 25, 2017 for the cash price of a 30-day supply of haloperidol 10 milligrams (30 tablets), risperidone 4mg (30 tablets), olanzapine 20mg (30 tablets), quetiapine 300mg (60 tablets), ziprasidone 80mg (60 tablets), and aripiprazole 20mg (30 tablets). Each pharmacy was then classified as being either a chain (n=182), grocery store (n= 53), or independent pharmacy (n= 30). Retail cash prices varied for all antipsychotic medications, with significant differences in price by pharmacy type. Price variation across all pharmacy types for a 30 day supply was the least for haloperidol (range 20.00 - 102.99) and the greatest for aripiprazole (range 29.99 - 1,345.00). Pairwise comparisons showed chain pharmacies had higher prices compared with independent pharmacies (p <.001) for all drugs except haloperidol (p =.49). Overall, chain pharmacies had the highest prices, with prices at grocery store pharmacies averaging 180.00 lower than chain and independent pharmacies 414.00 lower than chain pharmacies. This is the first report on the pharmacy-level variability in the costs of generic antipsychotic treatment options for schizophrenia. There are appreciable differences in the costs of antipsychotic medications and understanding variability in pricing for these medications may be valuable for providers serving uninsured patients. Further analyses will examine the contribution of geographic-level socio-demographic factors to these differences. Advisors/Committee Members: Venkitachalam, Lakshmi (advisor).

Subjects/Keywords: Generic drugs – Costs – Kansas City Metropolitan Area; Antipsychotic drugs – Costs – Kansas City Metropolitan Area; Schizophrenia; Schizophrenia – drug therapy; Drugs, Generic; Antipsychotic Agents; Pharmaceutical Preparations – economics; Thesis – University of Missouri – Kansas City – Medicine

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kriz, C. (2018). Variability in Pricing of Generic Antipsychotic Medications Used in the Treatment of Schizophrenia at Community Pharmacies in the Kansas City Metropolitan Area. (Thesis). University of Missouri – Kansas City. Retrieved from http://hdl.handle.net/10355/68866

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kriz, Carrie. “Variability in Pricing of Generic Antipsychotic Medications Used in the Treatment of Schizophrenia at Community Pharmacies in the Kansas City Metropolitan Area.” 2018. Thesis, University of Missouri – Kansas City. Accessed April 20, 2021. http://hdl.handle.net/10355/68866.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kriz, Carrie. “Variability in Pricing of Generic Antipsychotic Medications Used in the Treatment of Schizophrenia at Community Pharmacies in the Kansas City Metropolitan Area.” 2018. Web. 20 Apr 2021.

Vancouver:

Kriz C. Variability in Pricing of Generic Antipsychotic Medications Used in the Treatment of Schizophrenia at Community Pharmacies in the Kansas City Metropolitan Area. [Internet] [Thesis]. University of Missouri – Kansas City; 2018. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/10355/68866.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kriz C. Variability in Pricing of Generic Antipsychotic Medications Used in the Treatment of Schizophrenia at Community Pharmacies in the Kansas City Metropolitan Area. [Thesis]. University of Missouri – Kansas City; 2018. Available from: http://hdl.handle.net/10355/68866

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

13. Hornby, Megan. Neuroleptic use in the management of behavioral problems in a long-term care facility.

Degree: MS, 1990, Oregon Health Sciences University

URL: doi:10.6083/M4ZW1J2C ; http://digitalcommons.ohsu.edu/etd/1819

Subjects/Keywords: Nursing Homes; Behavior; Adjustment Disorders; Antipsychotic Agents; Aged; Long-Term Care

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hornby, M. (1990). Neuroleptic use in the management of behavioral problems in a long-term care facility. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M4ZW1J2C ; http://digitalcommons.ohsu.edu/etd/1819

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hornby, Megan. “Neuroleptic use in the management of behavioral problems in a long-term care facility.” 1990. Thesis, Oregon Health Sciences University. Accessed April 20, 2021. doi:10.6083/M4ZW1J2C ; http://digitalcommons.ohsu.edu/etd/1819.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hornby, Megan. “Neuroleptic use in the management of behavioral problems in a long-term care facility.” 1990. Web. 20 Apr 2021.

Vancouver:

Hornby M. Neuroleptic use in the management of behavioral problems in a long-term care facility. [Internet] [Thesis]. Oregon Health Sciences University; 1990. [cited 2021 Apr 20]. Available from: doi:10.6083/M4ZW1J2C ; http://digitalcommons.ohsu.edu/etd/1819.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hornby M. Neuroleptic use in the management of behavioral problems in a long-term care facility. [Thesis]. Oregon Health Sciences University; 1990. Available from: doi:10.6083/M4ZW1J2C ; http://digitalcommons.ohsu.edu/etd/1819

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Oulu

14. Saari, K. (Kaisa). Hyperlipidemia and metabolic syndrome in schizophrenia:a study of the Northern Finland 1966 Birth Cohort.

Degree: 2005, University of Oulu

URL: http://urn.fi/urn:isbn:9514277287

► Abstract Schizophrenia is associated with a shortened life expectancy and increased somatic comorbidity with e.g. cardiovascular disorders. The purpose of this study was to evaluate… (more)

▼ Abstract Schizophrenia is associated with a shortened life expectancy and increased somatic comorbidity with e.g. cardiovascular disorders. The purpose of this study was to evaluate hyperlipidemia and metabolic syndrome in schizophrenia and thus find specific risk factors for excess mortality and morbidity. The study population was a subsample of the Northern Finland 1966 Birth Cohort, a general population-based birth cohort. In 1997, 8,463 members of the cohort were invited to a clinical examination, where e.g. blood samples were taken after an overnight fast. Total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides (TG) were determined. The following psychiatric diagnostic categories were used: 1) DSM-III-R schizophrenia (n = 31), 2) other psychoses (n = 21), 3) non-psychotic disorders (n = 104), 4) comparison group (n = 5,498), having no psychiatric hospital treatment. Mean TC (5.5 mmol/l) and TG (1.5 mmol/l) were significantly higher in the schizophrenia group than in the comparison group (5.1 mmol/l and 1.2 mmol/l, respectively). To evaluate serum lipid levels in subjects with and without antipsychotic medication the sample was analyzed according to used medication. The prevalence of hypercholesterolemia, high LDL cholesterol and hypertriglyceridemia was high in persons using antipsychotic medication (31%, 20% and 22%, respectively) compared to persons without such medication (12%, 10% and 7%, respectively). We found higher triglyceride levels in patients who were ≤ 20 years old at the onset of schizophrenia (mean 1.7 mmol/l; N = 17) as compared with patients with later onset (mean 1.4 mmol/l; N = 14) or non-hospitalized controls (mean 1.2 mmol/l; N = 5,453). The difference between the first and third group was significant (p < 0.01), and there was a negative correlation between the age at onset and the level of serum triglycerides (r = -0.35, p = 0.05). To evaluate the prevalence of metabolic syndrome, the subjects were assessed for the presence of metabolic syndrome according to the criteria of the National Cholesterol Education Program. The prevalence of metabolic syndrome was high in subjects with schizophrenia compared with the comparison group (19% vs. 6%, p = 0.010). The results indicate an elevated risk for hyperlipidemia and metabolic syndrome in persons with schizophrenia or on antipsychotic medication. Regular monitoring of weight, serum lipid and glucose levels and blood pressure is important. Comprehensive efforts directed at controlling weight and improving physical activity are needed.

Subjects/Keywords: antipsychotic agents; cohort studies; metabolic syndrome x; psychotic disorders; schizophrenia; hyperlipidemia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Saari, K. (. (2005). Hyperlipidemia and metabolic syndrome in schizophrenia:a study of the Northern Finland 1966 Birth Cohort. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9514277287

Chicago Manual of Style (16^th Edition):

Saari, K (Kaisa). “Hyperlipidemia and metabolic syndrome in schizophrenia:a study of the Northern Finland 1966 Birth Cohort.” 2005. Doctoral Dissertation, University of Oulu. Accessed April 20, 2021. http://urn.fi/urn:isbn:9514277287.

MLA Handbook (7^th Edition):

Saari, K (Kaisa). “Hyperlipidemia and metabolic syndrome in schizophrenia:a study of the Northern Finland 1966 Birth Cohort.” 2005. Web. 20 Apr 2021.

Vancouver:

Saari K(. Hyperlipidemia and metabolic syndrome in schizophrenia:a study of the Northern Finland 1966 Birth Cohort. [Internet] [Doctoral dissertation]. University of Oulu; 2005. [cited 2021 Apr 20]. Available from: http://urn.fi/urn:isbn:9514277287.

Council of Science Editors:

Saari K(. Hyperlipidemia and metabolic syndrome in schizophrenia:a study of the Northern Finland 1966 Birth Cohort. [Doctoral Dissertation]. University of Oulu; 2005. Available from: http://urn.fi/urn:isbn:9514277287

University of Lund

15. Zahirovic, Iris. Recognition of dementia with Lewy bodies. Prevalence of core signs, medical treatments and survival in Swedish nursing homes and short-term homes.

Degree: 2019, University of Lund

URL: https://lup.lub.lu.se/record/caf7e981-1812-48f5-ab9d-79299aa67714 ; https://portal.research.lu.se/ws/files/69611670/Thesis_Avhandling_Iris_Zahirovic.pdf

► AbstractDementia with Lewy bodies (DLB) is an underdiagnosed neurocognitive disorder thatincludes several complex neurological and psychological signs, which are challenging toclinical diagnostics. The recognition of… (more)

▼ AbstractDementia with Lewy bodies (DLB) is an underdiagnosed neurocognitive disorder thatincludes several complex neurological and psychological signs, which are challenging toclinical diagnostics. The recognition of this neurocognitive disorder should beimproved because people with DLB exhibit a good treatment response to anti-dementiamedications but experience severe adverse events if treated with anti-psychoticmedicine.The main aim of this thesis was to investigate the prevalence of DLB core signs andmedical treatments among older adults living in nursing homes (NHs) and short-termNHs in an entire Swedish city. A second aim was to compare the survival betweenresidents of NHs with 0–1 and 2–4 DLB core signs.Design: For all papers, I applied a specially designed form covering all four core DLBsigns. This form was administered to residents of 40 NHs (N=650, mean age 86 years,75% women) in 2012–2013 and to residents of three short-term NHs (N=141, meanage 83 years, 63% women) in 2018. The registered nurse at each NH/short-term NHcompleted the form and collected the study data, including medication lists. For PaperIV, data were obtained from short-term NHs, and the participating residents (N=112)were given a medical examination by physicians.Results: In Paper I, we found a prevalence of 2–4 DLB core signs in 16–20% of all610 NH residents. In Paper II, analysis of the rates of treatment with psychotropicsshowed use of anti-psychotics by 23% of residents, hypnotics/sedatives by 41% andanti-dementia medications by 33% of the entire study population. Use of antipsychoticsincreased from 25% to 43% in residents with an increasing number of DLBcore signs. In Paper III, the mean survival differed between residents according to thenumber of DLB signs; those with 0–1 DLB signs lived 8 months longer than thosewith 2–4 DLB signs. In Paper IV, we found a prevalence of 2–4 DLB core signs in32% of all short-term NH residents.Conclusion: In both NHs and short-term NHs, 16–32% of residents had 2–4 DLBcore signs. These “high-risk DLB residents” also received unfavourable medicaltreatment, as shown by the high use of anti-psychotic medicine and shorter survivalcompared with residents with 0–1 DLB core signs.Populärvetenskaplig sammanfattningEnligt statistiska prognoser beräknas Sveriges och världens population av äldre ökakraftigt de nästkommande åren. Kognitiva sjukdomar (demens) är åldersrelaterade och2015 estimerades prevalensen i världen till 47 miljoner människor.I Sverige idag finns det 160000 människor med en demensdiagnos, med en årlig ökningmed 25000 nya insjuknande. Demens, ett paraplybegrepp med flera olika sjukdomar,består av den vanligaste Alzheimers sjukdom följd av andra subtyper såsom vaskulärdemens och Lewy body demens (LBD). I denna avhandling har vi fokuserat på LBDvars diagnoskriterier först sammanställdes i början av 90-talet. Lewy body demens ärinte enkel att diagnostisera, med bl.a. tecken på varierande parkinsonliknanderörelsebesvär, minnesbesvär, synhallucinationer med insikt och störd drömsömn.Dagens forskning…

Subjects/Keywords: Medical and Health Sciences; DEMENTIA; Dementia care; Lewy Body Disease; Geriatric Medicine; Neurocognitive disorders; Antipsychotic Agents/therapeutic use; Survival; Prevalence of symptoms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zahirovic, I. (2019). Recognition of dementia with Lewy bodies. Prevalence of core signs, medical treatments and survival in Swedish nursing homes and short-term homes. (Doctoral Dissertation). University of Lund. Retrieved from https://lup.lub.lu.se/record/caf7e981-1812-48f5-ab9d-79299aa67714 ; https://portal.research.lu.se/ws/files/69611670/Thesis_Avhandling_Iris_Zahirovic.pdf

Chicago Manual of Style (16^th Edition):

Zahirovic, Iris. “Recognition of dementia with Lewy bodies. Prevalence of core signs, medical treatments and survival in Swedish nursing homes and short-term homes.” 2019. Doctoral Dissertation, University of Lund. Accessed April 20, 2021. https://lup.lub.lu.se/record/caf7e981-1812-48f5-ab9d-79299aa67714 ; https://portal.research.lu.se/ws/files/69611670/Thesis_Avhandling_Iris_Zahirovic.pdf.

MLA Handbook (7^th Edition):

Zahirovic, Iris. “Recognition of dementia with Lewy bodies. Prevalence of core signs, medical treatments and survival in Swedish nursing homes and short-term homes.” 2019. Web. 20 Apr 2021.

Vancouver:

Zahirovic I. Recognition of dementia with Lewy bodies. Prevalence of core signs, medical treatments and survival in Swedish nursing homes and short-term homes. [Internet] [Doctoral dissertation]. University of Lund; 2019. [cited 2021 Apr 20]. Available from: https://lup.lub.lu.se/record/caf7e981-1812-48f5-ab9d-79299aa67714 ; https://portal.research.lu.se/ws/files/69611670/Thesis_Avhandling_Iris_Zahirovic.pdf.

Council of Science Editors:

Zahirovic I. Recognition of dementia with Lewy bodies. Prevalence of core signs, medical treatments and survival in Swedish nursing homes and short-term homes. [Doctoral Dissertation]. University of Lund; 2019. Available from: https://lup.lub.lu.se/record/caf7e981-1812-48f5-ab9d-79299aa67714 ; https://portal.research.lu.se/ws/files/69611670/Thesis_Avhandling_Iris_Zahirovic.pdf

Tampere University

16. Kampman, Olli. Compliance in Psychotic Disorders .

Degree: Lääketieteen laitos - Medical School, 2003, Tampere University

URL: https://trepo.tuni.fi/handle/10024/67303

► Miksi vaikeiden mielenterveyshäiriöiden hoito on vaikeaa? Tutkimus kuuluu psykiatrian oppialaan. Tutkimuksen tulokset tarjoavat käytännön mahdollisuuksia vaikeiden mielenterveyshäiriöiden nykyistä parempaan hoitoon. Psykoosi on vaikea-asteinen mielenterveyden häiriö,… (more)

▼ Miksi vaikeiden mielenterveyshäiriöiden hoito on vaikeaa? Tutkimus kuuluu psykiatrian oppialaan. Tutkimuksen tulokset tarjoavat käytännön mahdollisuuksia vaikeiden mielenterveyshäiriöiden nykyistä parempaan hoitoon. Psykoosi on vaikea-asteinen mielenterveyden häiriö, johon voi liittyä havainnoinnin, ajattelun sekä muisti- ja päättelytoimintojen häiriintymistä siten, että käsitys todellisuudesta vääristyy. Skitsofrenia on häiriö, jossa esiintyy toistuvia psykooseja tai jatkuvia oireita. Potilaan vaikeus tunnistaa oireitaan saattaa johtaa hoidon viivästymiseen tai keskeytymiseen. Hoitamaton psykoosi lisää varhaisen kuoleman ja somaattisen sairastumisen riskiä. Tutkimuksessa kehitettiin kysely, joka kartoittaa asenteita lääkehoitoa kohtaan. Kyselyn toimivuus testattiin 106 antipsykoottista lääkitystä käyttävällä psykiatrisen erikoissairaanhoidon potilaalla. Lisäksi lääkkeiden käytön säännöllisyys arvioitiin vertaamalla potilailta saatua tietoa hoitavien lääkäreiden arvioon. Kehitetty kyselylomake (ANT) osoittautui rakenteeltaan toimivaksi. Neljännes potilaista arvioi käyttäneensä alle puolet heille määrätystä lääkityksestä. Potilaan optimistiseen arvioon lääkkeiden käytöstään lääkärin arvioon verrattuna liittyi maaninen psykoosi, suuriannoksinen lääkitys ja kielteiset asenteet lääkehoitoa kohtaan lääkärin arvioimana. Toisessa osatutkimuksessa arvioitiin 59 ensi kertaa psykoosin vuoksi erikoissairaanhoitoon lähetetyn potilaan hoitomyöntyvyyttä. Kolmen kuukauden seuranta-aikana viidennes potilaista poikkesi annetuista lääkehoito-ohjeista. Vajaa kolmannes potilaista asennoitui kielteisesti lääkehoitoon hoidon alussa. Asenteilla ja lääkehoidon laiminlyönnillä ei ollut keskinäistä yhteyttä. Lääkityksen epäsäännölliseen käyttöön tai sen keskeyttämiseen liittyi haittaoireiden kokeminen. Hoito-ohjeista poikkeaminen oli todennäköisintä nuorilla miespotilailla, joilta puuttui sosiaaliset kontaktit. Lisäksi 80 potilaan otoksessa verrattiin ensipsykoosin hoitodiagnooseja puolistrukturoidulla (SCAN-2) haastattelumenetelmällä saatuihin tutkimusdiagnooseihin. Hoito- ja tutkimusdiagnoosit olivat yhteneviä alle puolella tutkituista. Harhaluulo-oireet, alhainen koulutustaso ja vähäiset psykoosin puutosoireet olivat yhteydessä eroavaisuuksiin hoito- ja tutkimusdiagnoosien välillä. Hoidon tuloksellisuutta ja sairaalahoitojen määrää arvioitiin sairauskertomustietojen perusteella 41 skitsofreniaa sairastavalla pitkäaikaispotilaalla, joilla oli toistuvia sairausjaksoja. Vajaa puolet potilaista sai neljän vuoden seuranta-aikana kotikäynteihin perustuvaa avohoitoa. Vertailuryhmän potilaat kävivät mielenterveystoimiston avohoidossa. Neljän vuoden aikana sairaalahoitojen määrä väheni molemmissa ryhmissä selvästi, kotihoitoa saavilla lähes viidennekseen vertailujaksoon nähden. Potilaiden toimintakyvyssä ryhmien välillä ei ollut eroja. Kuolleisuus kotihoitoryhmässä oli skitsofreniapotilaiden keskimääräiseen kuolleisuuteen verrattuna samalla tasolla, mutta vertailuryhmässä sitä korkeampi. Vaikeiden mielenterveyshäiriöiden hoitoa hankaloittavat…

Subjects/Keywords: psykoosi ; skitsofrenia ; hoitomyöntyvyys ; antipsykootti ; psychotic disorders ; schizophrenia ; patient compliance ; antipsychotic agents

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kampman, O. (2003). Compliance in Psychotic Disorders . (Doctoral Dissertation). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/67303

Chicago Manual of Style (16^th Edition):

Kampman, Olli. “Compliance in Psychotic Disorders .” 2003. Doctoral Dissertation, Tampere University. Accessed April 20, 2021. https://trepo.tuni.fi/handle/10024/67303.

MLA Handbook (7^th Edition):

Kampman, Olli. “Compliance in Psychotic Disorders .” 2003. Web. 20 Apr 2021.

Vancouver:

Kampman O. Compliance in Psychotic Disorders . [Internet] [Doctoral dissertation]. Tampere University; 2003. [cited 2021 Apr 20]. Available from: https://trepo.tuni.fi/handle/10024/67303.

Council of Science Editors:

Kampman O. Compliance in Psychotic Disorders . [Doctoral Dissertation]. Tampere University; 2003. Available from: https://trepo.tuni.fi/handle/10024/67303

17. Juliano dos Santos Souza. Eficácia de antipsicóticos atípicos comparados à clozapina em pacientes com esquizofrenia refratária: revisão sistemática e metanálise.

Degree: 2010, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-04112010-160946/

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INTRODUÇÃO: Considera-se a clozapina como padrão-ouro para o tratamento de pacientes com esquizofrenia refratária, com base principalmente em sua eficácia comprovadamente superior em relação aos… (more)

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INTRODUÇÃO: Considera-se a clozapina como padrão-ouro para o tratamento de pacientes com esquizofrenia refratária, com base principalmente em sua eficácia comprovadamente superior em relação aos antipsicóticos típicos. No entanto, os dados acerca do uso de outros antipsicóticos atípicos ainda são escassos ou divergentes. Tendo em vista que o uso de clozapina está associado a várias limitações, existe uma necessidade não atendida de alternativas terapêuticas eficazes e seguras para a esquizofrenia refratária. MÉTODOS: Foi realizada uma revisão sistemática de estudos controlados e randomizados (ECRs), comparando clozapina aos outros antipsicóticos atípicos, em pacientes com esquizofrenia refratária. Foram realizadas metanálises avaliando a eficácia das intervenções, medida por meio de escalas de avaliação de sintomas psicóticos. A resposta ao tratamento foi medida por meio da porcentagem de respondedores ou pela mudança média ou valores finais dos escores das escalas. Quando possível, foram realizadas metanálises da comparação entre clozapina e outro antipsicótico atípico específico. Os tamanhos de efeito foram dados pelo risco relativo (RR) ou pela diferença entre médias (DM), ponderada ou padronizada, acompanhados dos respectivos intervalos de confiança de 95%. As metanálises foram realizadas utilizando-se o modelo de efeitos fixos, ou aleatórios, no caso de haver heterogeneidade entre os estudos. Foram realizadas análises de sensibilidade, excluindo-se estudos que haviam incluído pacientes intolerantes junto à população refratária. RESULTADOS: Onze ECRs foram incluídos, representando 1182 pacientes, com 12 comparações entre clozapina e antipsicóticos atípicos: quatro com risperidona, um com ziprasidona e sete com olanzapina. Considerados como um grupo, não foi possível determinar diferenças no tamanho de efeito entre a clozapina e os outros antipsicóticos atípicos em nenhum tipo de medida geral de sintomas psicóticos. A metanálise que combinou as mudanças médias e os valores finais da PANSS e da BPRS apresentou uma diferença de médias de 0,00 (IC95%= -0,12, 011). Foi observada superioridade marginal dos antipsicóticos atípicos para sintomas negativos, medidos pelos valores finais da PANSS (DM= -1,96, IC95%= -3,44, -0,48). Foi observado que os estudos que compararam a clozapina à olanzapina tiveram doses finais médias altas de olanzapina (médias de 17,2 mg/d a 33,6 mg/d), o que pode ter influenciado nos resultados.CONCLUSÕES: Os antipsicóticos atípicos, particularmente a olanzapina em doses altas, podem representar uma alternativa de tratamento para pacientes com esquizofrenia refratária

BACKGROUND: Clozapine is considered as the gold standard for the treatment of patients with refractory schizophrenia, based upon its well established superior efficacy against typical antipsychotics. Nevertheless, data on other atypical antipsychotics are still scarce or divergent for this population. Considering that clozapine use is associated to several caveats, there is an unmet need for safe and efficacious…

Advisors/Committee Members: Helio Elkis, Orestes Vicente Forlenza, Maurício Silva de Lima.

Subjects/Keywords: Agentes antipsicóticos; Clozapina; Esquizofrenia; Metanálise; Antipsychotic agents; Clozapine; Metanalysis; Schizophrenia

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Souza, J. d. S. (2010). Eficácia de antipsicóticos atípicos comparados à clozapina em pacientes com esquizofrenia refratária: revisão sistemática e metanálise. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5142/tde-04112010-160946/

Chicago Manual of Style (16^th Edition):

Souza, Juliano dos Santos. “Eficácia de antipsicóticos atípicos comparados à clozapina em pacientes com esquizofrenia refratária: revisão sistemática e metanálise.” 2010. Masters Thesis, University of São Paulo. Accessed April 20, 2021. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-04112010-160946/.

MLA Handbook (7^th Edition):

Souza, Juliano dos Santos. “Eficácia de antipsicóticos atípicos comparados à clozapina em pacientes com esquizofrenia refratária: revisão sistemática e metanálise.” 2010. Web. 20 Apr 2021.

Vancouver:

Souza JdS. Eficácia de antipsicóticos atípicos comparados à clozapina em pacientes com esquizofrenia refratária: revisão sistemática e metanálise. [Internet] [Masters thesis]. University of São Paulo; 2010. [cited 2021 Apr 20]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-04112010-160946/.

Council of Science Editors:

Souza JdS. Eficácia de antipsicóticos atípicos comparados à clozapina em pacientes com esquizofrenia refratária: revisão sistemática e metanálise. [Masters Thesis]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-04112010-160946/

Universidade Estadual de Campinas

18. Pivetta, Rhannanda Copetti, 1992-. Contaminantes de preocupação emergente : determinação de fármacos psicoativos em efluente e águas superficiais.

Degree: Instituto de Química; Programa de Pós-Graduação em Química, 2019, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/335313

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Orientador: Susanne Rath

Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química

Made available in DSpace on 2019-10-24T16:52:50Z (GMT). No. of bitstreams: 1 Pivetta_RhannandaCopetti_M.pdf:… (more)

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Orientador: Susanne Rath

Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química

Made available in DSpace on 2019-10-24T16:52:50Z (GMT). No. of bitstreams: 1 Pivetta_RhannandaCopetti_M.pdf: 2641007 bytes, checksum: 78c98b84c71ab7467b60cb2511b0f564 (MD5) Previous issue date: 2019

Resumo: O uso de medicamentos contendo insumos farmacêuticos psicoativos tem crescido a nível mundial nas últimas décadas e, também, no Brasil. Esses fármacos, são de modo geral muito metabolizados e apenas uma pequena fração na forma original é excretada. No entanto, esses compostos são pouco removidos em estações de tratamento de esgoto convencionais e, uma vez lançados em corpos hídricos, podem impactar o ambiente. O objetivo desse trabalho foi avaliar a presença de fármacos psicoativos em águas superficiais e em cinco estações de tratamento de esgoto (ETE) da cidade de Campinas, São Paulo, Brasil. Para tanto, foram priorizados os fármacos psicoativos mais consumidos no Brasil e desenvolvido e validado um método analítico, empregando a extração em fase sólida on-line à cromatografia líquida de ultra-alta eficiência acoplada a espectrometria de massas sequencial (SPE-UHPLC-MS/MS), para determinar alprazolam, amitriptilina, bupropiona, carbamazepina, clonazepam, escitalopram, fluoxetina, nortriptilina, sertralina e trazodona. A concentração dos analitos foi realizada no sistema SPE on-line, utilizando uma coluna Oasis HLB e foram determinados os seguintes parâmetros: vazão da fase de carregamento da amostra (1,0 mL min-1), tempo de carregamento da amostra (0,5 min), solvente de carregamento água:acetonitrila (80:20, v/v) e volume de injeção da amostra de 250 µL. A separação cromatográfica foi realizada em uma coluna UPLC CSH C18, com fase móvel composta de 0,1% ácido fórmico em água:acetonitrila, e eluição em gradiente. O limite de quantificação do método foi de 50 ng L-1 para todos os analitos. Para as amostras de água superficial foram detectadas concentrações máximas de 2.530 ng L-1, 1.880 ng L-1 e 90 ng L-1 para carbamazepina, bupropiona e fluoxetina, respectivamente. Para as amostras das ETE foram detectados oito dos dez analitos priorizados, atingindo concentrações máximas no efluente tratado de 3.000 ng L-1 para a carbamazepina, 1.136 ng L-1 para o escitalopram, 185 ng L-1 para a bupropiona e 145 ng L-1 para a fluoxetina. Os processos empregados nas cinco estações de tratamento de esgoto não são suficientes para a remoção completa dos fármacos em estudo e técnicas de polimento adicionais são recomendadas

The use of drugs containing psychoactive pharmaceuticals has been growing worldwide over the last decades, and also in Brazil. These drugs are generally highly metabolized, and only a small fraction is excreted in its original form. Since these drugs are not completely removed in the conventional wastewater treatment plants, they have been spread into the surface water and may impact the environment. The objective of this work was to assess the presence of psychoactive pharmaceuticals in surface…

Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS, Rath, Susanne, 1962-, Cunha, Davi Gasparini Fernandes, Fostier, Anne Hélène.

Subjects/Keywords: Antipsicóticos; Águas superficiais; Contaminantes emergentes; Fármacos; On-line SPE-UHPLC-MS/MS; Antipsychotic agents; Surface waters; Emerging contaminants; Drugs; On-line SPE-UHPLC-MS/MS

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pivetta, Rhannanda Copetti, 1. (2019). Contaminantes de preocupação emergente : determinação de fármacos psicoativos em efluente e águas superficiais. (Masters Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/335313

Chicago Manual of Style (16^th Edition):

Pivetta, Rhannanda Copetti, 1992-. “Contaminantes de preocupação emergente : determinação de fármacos psicoativos em efluente e águas superficiais.” 2019. Masters Thesis, Universidade Estadual de Campinas. Accessed April 20, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/335313.

MLA Handbook (7^th Edition):

Pivetta, Rhannanda Copetti, 1992-. “Contaminantes de preocupação emergente : determinação de fármacos psicoativos em efluente e águas superficiais.” 2019. Web. 20 Apr 2021.

Vancouver:

Pivetta, Rhannanda Copetti 1. Contaminantes de preocupação emergente : determinação de fármacos psicoativos em efluente e águas superficiais. [Internet] [Masters thesis]. Universidade Estadual de Campinas; 2019. [cited 2021 Apr 20]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/335313.

Council of Science Editors:

Pivetta, Rhannanda Copetti 1. Contaminantes de preocupação emergente : determinação de fármacos psicoativos em efluente e águas superficiais. [Masters Thesis]. Universidade Estadual de Campinas; 2019. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/335313

19. Tort, Adriano Bretanha Lopes. Sistemas dopaminérgicos e ação antipsicótica: abordagens experimentais e teóricas.

Degree: 2005, Universidade Federal do Rio Grande do Sul; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica; UFRGS; Brasil; Departamento de Bioquímica

URL: http://hdl.handle.net/10183/5900&

► Os objetivos da presente tese de doutorado foram os de buscar novos antipsicóticos atípicos de baixo preço comercial e também procurar entender o mecanismo de… (more)

▼ Os objetivos da presente tese de doutorado foram os de buscar novos antipsicóticos atípicos de baixo preço comercial e também procurar entender o mecanismo de ação que leva a um perfil antipsicótico atípico. Os resultados da tese são divididos em duas partes, de acordo com sua natureza, em experimentais (primeira parte) e teóricos (segunda parte). Para o desenvolvimento da primeira parte, foi necessária primeiramente a programação de um software para medir locomoção em roedores após filmagem com webcam. A seguir, foram investigados os efeitos da guanosina, flunarizina e cinarizina em modelos animais de psicose, bem como em outros paradigmas comportamentais. A guanosina foi escolhida para estudo uma vez que tem se mostrado que ela interage com o sistema glutamatérgico – que sabidamente está envolvido na fisiopatologia da esquizofrenia – promovendo a captação astrocitária de glutamato. Já a flunarizina e a cinarizina, dois bloqueadores de canal de cálcio empregados para tratar enxaqueca e vertigem foram escolhidas pelo fato delas produzirem sinais e sintomas extrapiramidais em pacientes idosos, o que posteriormente foi relacionado às suas propriedades como antagonistas moderados dos receptores dopaminérgicos do tipo D2. A guanosina diminuiu o aumento de locomoção induzido por um antagonista NMDA (MK-801), enquanto que não apresentou efeito sobre o aumento de locomoção induzido por anfetamina, de forma que sua utilidade como potencial antipsicótico deve ser ainda melhor estudada. Tanto a flunarizina quanto a cinarizina foram capazes de diminuir o aumento de locomoção induzido por MK-801 e por anfetamina em doses que não causam efeitos catalépticos importantes. Portanto, foi concluído que estes dois compostos apresentam um potencial perfil de antipsicótico atípico, com as vantagens de já estarem disponíveis para uso comercial, boa tolerabilidade e baixo custo quando comparados com os antipsicóticos atípicos disponíveis comercialmente nos dias de hoje. A segunda parte da tese apresenta alguns resultados teóricos matemáticos que podem ser derivados da teoria da lei de ação das massas aplicada ao binding de receptores, utilizando também resultados experimentais já conhecidos de PET. Estes resultados apresentam insights ao entendimento das diferenças entre os perfis antipsicóticos atípicos e típicos em relação à geração de sinais extrapiramidais. É discutido que fatores culturais e comerciais relacionados à posologia atual empregada no tratamento com antipsicóticos típicos podem ser os responsáveis pelas diferenças de perfis, uma vez que alguns deles são prescritos em doses proporcionalmente maiores em relação à sua afinidade, atingindo assim maiores níveis de bloqueio dopaminérgico no estriado. Uma curta meia-vida plasmática também é apontada como um possível parâmetro importante na geração de um perfil atípico. É mostrado ainda alguns erros de concepção relacionados ao curso temporal da ocupação dopaminérgica que tem sido atualmente cometidos na literatura científica, como o conceito de meia-vida de ocupação de… Advisors/Committee Members: http://lattes.cnpq.br/9534019126486839, Lara, Diogo Rizzato, Souza, Diogo Onofre Gomes de.

Subjects/Keywords: CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA; Antipsicoticos; Psicofarmacologia; Dopamineregic system; Psychopharmacology; Antipsychotic agents; Sistema dopaminérgico

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tort, A. B. L. (2005). Sistemas dopaminérgicos e ação antipsicótica: abordagens experimentais e teóricas. (Doctoral Dissertation). Universidade Federal do Rio Grande do Sul; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica; UFRGS; Brasil; Departamento de Bioquímica. Retrieved from http://hdl.handle.net/10183/5900&

Chicago Manual of Style (16^th Edition):

Tort, Adriano Bretanha Lopes. “Sistemas dopaminérgicos e ação antipsicótica: abordagens experimentais e teóricas.” 2005. Doctoral Dissertation, Universidade Federal do Rio Grande do Sul; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica; UFRGS; Brasil; Departamento de Bioquímica. Accessed April 20, 2021. http://hdl.handle.net/10183/5900&.

MLA Handbook (7^th Edition):

Tort, Adriano Bretanha Lopes. “Sistemas dopaminérgicos e ação antipsicótica: abordagens experimentais e teóricas.” 2005. Web. 20 Apr 2021.

Vancouver:

Tort ABL. Sistemas dopaminérgicos e ação antipsicótica: abordagens experimentais e teóricas. [Internet] [Doctoral dissertation]. Universidade Federal do Rio Grande do Sul; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica; UFRGS; Brasil; Departamento de Bioquímica; 2005. [cited 2021 Apr 20]. Available from: http://hdl.handle.net/10183/5900&.

Council of Science Editors:

Tort ABL. Sistemas dopaminérgicos e ação antipsicótica: abordagens experimentais e teóricas. [Doctoral Dissertation]. Universidade Federal do Rio Grande do Sul; Programa de Pós-Graduação em Ciências Biológicas: Bioquímica; UFRGS; Brasil; Departamento de Bioquímica; 2005. Available from: http://hdl.handle.net/10183/5900&

University of Florida

20. Alvarez, Francisco Martin, 1951-. Neolignans of Saururus Cernuus L.

Degree: 1981, University of Florida

URL: https://ufdc.ufl.edu/AA00009116

Subjects/Keywords: Antipsychotic agents; Chromatography; Dosage; Ethers; Lignans; Protons; Purification; Silica gel; Solvents; Toxicity; Antipsychotic Agents ( mesh ); Medicinal Chemistry thesis Ph.D ( mesh ); Pharmocognosy ( mesh ); Plants, Medicinal ( mesh )

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Alvarez, Francisco Martin, 1. (1981). Neolignans of Saururus Cernuus L. (Thesis). University of Florida. Retrieved from https://ufdc.ufl.edu/AA00009116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Alvarez, Francisco Martin, 1951-. “Neolignans of Saururus Cernuus L.” 1981. Thesis, University of Florida. Accessed April 20, 2021. https://ufdc.ufl.edu/AA00009116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Alvarez, Francisco Martin, 1951-. “Neolignans of Saururus Cernuus L.” 1981. Web. 20 Apr 2021.

Vancouver:

Alvarez, Francisco Martin 1. Neolignans of Saururus Cernuus L. [Internet] [Thesis]. University of Florida; 1981. [cited 2021 Apr 20]. Available from: https://ufdc.ufl.edu/AA00009116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Alvarez, Francisco Martin 1. Neolignans of Saururus Cernuus L. [Thesis]. University of Florida; 1981. Available from: https://ufdc.ufl.edu/AA00009116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

21. Stolker, J.J. Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings.

Degree: 2002, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/428

► The main objectives of this thesis were to establish the prevalence of psychotropic drug use as well as possible determinants associated with its use in… (more)

▼ The main objectives of this thesis were to establish the prevalence of psychotropic drug use as well as possible determinants associated with its use in multiple clinical settings: psychiatric admission wards, an intensive care unit and two settings for the intellectually disabled. In this thesis, we evaluated the question which class of antipsychotics is prescribed preferentially in newly admitted patients on psychiatric admission wards and the determinants affecting this decision. We found that the most frequently prescribed oral antipsychotic drugs were classical agents. Initial choice for short-acting parenteral classical antipsychotics was significantly associated with follow-up prescriptions of oral classical antipsychotics. We predict that upcoming introductions of short-acting parenteral formulations of atypical agents are likely to have a large impact on the subsequent oral antipsychotic treatment. In another study on psychiatric admission wards, we looked at the temporal relationship between the use of antipsychotics and seclusion. Antipsychotic treatment in patients with psychotic disorders was significantly associated with a delay of seclusion and, although not statistically significant, with a lower risk of seclusion. Furthermore, in a substantial proportion of the patients, antipsychotic therapy was only initiated during or directly following seclusion with a relative risk of 2.0 (95% confidence interval: 1.2-3.4). Our findings suggest that, in patients with psychotic disorders, not using antipsychotics is associated with aggression or violence for which seclusion is needed. Pharmacological treatment seems inevitable for a substantial proportion of secluded psychotic patients. Furthermore, we studied determinants of psychotropic drug use in a general intensive care unit (ICU). The prevalence of psychotropic drug use was 42.3%. Benzodiazepines were used in 35.8% of the patients, frequently at a high dosage. Antipsychotics were prescribed in 17.5% of all patients, typically in low dosages. The association of severe disease, a long ICU stay and an admission for non-surgical reasons with psychotropic drug use may be an indication that severely ill patients are likely to suffer from a delirium. In this study, patients who used psychotropic drugs (cases) acted as their own controls because days of drug exposure were compared to those of non-exposure and no corrections were made with the fact that observations were correlated. We compared this design with a logistical binomial model to adjust for correlated measures, or cluster effects through repeated measures and found that, although adjustment did not result in major changes in the odds ratios found, adjustment has greater effect with more observations per cluster. In a study in group homes for intellectually disabled residents, the point prevalence of psychotropic drug use in a problem behaviour group (PBG) was compared to a random group (RG) of residents and possible determinants of group membership were studied. Psychotropics were used by…

Subjects/Keywords: Geneeskunde; pharmacoepidemiology; drug utilization; psychotropic drugs; polypharmacy; antipsychotic agents; psychiatric hospitals; intensive care units; mental retardation; group homes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stolker, J. J. (2002). Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings. (Doctoral Dissertation). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/428

Chicago Manual of Style (16^th Edition):

Stolker, J J. “Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings.” 2002. Doctoral Dissertation, Universiteit Utrecht. Accessed April 20, 2021. http://dspace.library.uu.nl:8080/handle/1874/428.

MLA Handbook (7^th Edition):

Stolker, J J. “Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings.” 2002. Web. 20 Apr 2021.

Vancouver:

Stolker JJ. Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings. [Internet] [Doctoral dissertation]. Universiteit Utrecht; 2002. [cited 2021 Apr 20]. Available from: http://dspace.library.uu.nl:8080/handle/1874/428.

Council of Science Editors:

Stolker JJ. Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings. [Doctoral Dissertation]. Universiteit Utrecht; 2002. Available from: http://dspace.library.uu.nl:8080/handle/1874/428

22. Gourley, Lynn. Effects of acute and chronic administration of thioridazine on cardiovascular responses :.

Degree: MS, 1978, Oregon Health Sciences University

URL: doi:10.6083/M4PG1PXM ; http://digitalcommons.ohsu.edu/etd/2394

Subjects/Keywords: Autonomic Nervous System – drug effects; Cardiovascular System – drug effects; Antipsychotic Agents – adverse effects; Thioridazine – adverse effects

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gourley, L. (1978). Effects of acute and chronic administration of thioridazine on cardiovascular responses :. (Thesis). Oregon Health Sciences University. Retrieved from doi:10.6083/M4PG1PXM ; http://digitalcommons.ohsu.edu/etd/2394

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gourley, Lynn. “Effects of acute and chronic administration of thioridazine on cardiovascular responses :.” 1978. Thesis, Oregon Health Sciences University. Accessed April 20, 2021. doi:10.6083/M4PG1PXM ; http://digitalcommons.ohsu.edu/etd/2394.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gourley, Lynn. “Effects of acute and chronic administration of thioridazine on cardiovascular responses :.” 1978. Web. 20 Apr 2021.

Vancouver:

Gourley L. Effects of acute and chronic administration of thioridazine on cardiovascular responses :. [Internet] [Thesis]. Oregon Health Sciences University; 1978. [cited 2021 Apr 20]. Available from: doi:10.6083/M4PG1PXM ; http://digitalcommons.ohsu.edu/etd/2394.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gourley L. Effects of acute and chronic administration of thioridazine on cardiovascular responses :. [Thesis]. Oregon Health Sciences University; 1978. Available from: doi:10.6083/M4PG1PXM ; http://digitalcommons.ohsu.edu/etd/2394

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Dickson, Marguerite Mulryan. Genetic and psychiatric treatment related risk factors for type 2 diabetes in schizophrenia and schizoaffective disorder patients.

Degree: PhD, 2008, University of Alabama – Birmingham

URL: http://contentdm.mhsl.uab.edu/u?/etd,388

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Type 2 diabetes (T2D) is a complex disease with genetic and environmental components. An increased prevalence of T2D in patients with schizophrenia (SCZ) has been… (more)

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Type 2 diabetes (T2D) is a complex disease with genetic and environmental components. An increased prevalence of T2D in patients with schizophrenia (SCZ) has been observed. Exposure to psychiatric medications such as antipsychotics (APs) have been shown to induce weight gain and T2D in some patients providing a unique opportunity to study gene and treatment related risk for T2D. Linkage and association studies have identified important candidate genes for T2D that may interact with AP medication to induce T2D with biological plausibility including TCF7L2, CAPN10, and ENNP1. The PAARTNERS study is a unique population (N~3000) of African American families with at least one SCZ or schizoaffective (SAD) member in addition to 412 mentally healthy African American controls recruited at 8 sites throughout the eastern US. The current study of PAARTNERS SCZ and SAD cases (N=891), exposed to similar psychiatric medication regimens, examined select genetic and treatment related risk factors for T2D. It was hypothesized that AP treatment may interfere with cellular, signal transduction pathways important in metabolism, specifically the WNT and insulin signaling pathways. Among SCZ/SAD cases, results show main effect associations with T2D of TCF7L2 (rs7903146) with OR=2.6 (p=0.003) and CAPN10(rs3792267) with OR=1.65 (p=0.05), both involved in the WNT signaling pathway. Current AP treatment was associated with increased odds of T2D with OR=2.4 (p=0.02) and results for specific current AP medications were consistent with the extensive literature on antipsychotic induced weight gain and T2D (clozapine, OR=3.0, p=0.01). Current valproic acid treatment increased the odds of having T2D three fold after adjustment for AP treatment (p=0.002). Interestingly, for stratified analysis that included controls results were suggestive of a TCF7L2 by current AP treatment interaction on the multiplicative scale for increased risk for T2D (OR=1.7, p=0.3 for TCF7L2 risk genotype, no AP treatment; OR=2.7 p<0.0001 for AP treatment, wild type TCF7L2; OR=6.3, p<0.001 for both and 1.7*2.7<6.3). A major limitation of the pilot study is that PAARTNERS is a crosssectional study and we were unable to measure specific AP treatment at T2D onset, dose, duration and even that AP treatment preceded T2D onset.

xii, 134 p. : ill., digital, PDF file.

Epidemiology

Public Health

Type 2 Diabetes TCF7L2 CAPN10 ENPP1 Schizophrenia Antipsychotics

UNRESTRICTED

Advisors/Committee Members: Go, Rodney C.P., Arnett, Donna K.<br>Kabagambe, Edmond K.<br>Tiwari, Hemant K.<br>Savage, Robert M..

Subjects/Keywords: Antipsychotic Agents – adverse effects<; br>; Diabetes Mellitus, Type 2 – chemically induced<; br>; Genetic Predisposition to Disease<; br>; Psychotic Disorders – drug therapy<; br>; Risk Factors<; br>; Schizophrenia – drug therapy<; br>; Weight Gain – drug effects

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dickson, M. M. (2008). Genetic and psychiatric treatment related risk factors for type 2 diabetes in schizophrenia and schizoaffective disorder patients. (Doctoral Dissertation). University of Alabama – Birmingham. Retrieved from http://contentdm.mhsl.uab.edu/u?/etd,388

Chicago Manual of Style (16^th Edition):

Dickson, Marguerite Mulryan. “Genetic and psychiatric treatment related risk factors for type 2 diabetes in schizophrenia and schizoaffective disorder patients.” 2008. Doctoral Dissertation, University of Alabama – Birmingham. Accessed April 20, 2021. http://contentdm.mhsl.uab.edu/u?/etd,388.

MLA Handbook (7^th Edition):

Dickson, Marguerite Mulryan. “Genetic and psychiatric treatment related risk factors for type 2 diabetes in schizophrenia and schizoaffective disorder patients.” 2008. Web. 20 Apr 2021.

Vancouver:

Dickson MM. Genetic and psychiatric treatment related risk factors for type 2 diabetes in schizophrenia and schizoaffective disorder patients. [Internet] [Doctoral dissertation]. University of Alabama – Birmingham; 2008. [cited 2021 Apr 20]. Available from: http://contentdm.mhsl.uab.edu/u?/etd,388.

Council of Science Editors:

Dickson MM. Genetic and psychiatric treatment related risk factors for type 2 diabetes in schizophrenia and schizoaffective disorder patients. [Doctoral Dissertation]. University of Alabama – Birmingham; 2008. Available from: http://contentdm.mhsl.uab.edu/u?/etd,388

24. Schmidt, Karl F. Development of Pharmacological Magnetic Resonance Imaging Methods and their Application to the Investigation of Antipsychotic Drugs: a Dissertation.

Degree: Neuroscience, Psychiatry, 2006, U of Massachusetts : Med

URL: https://escholarship.umassmed.edu/gsbs_diss/114

► Pharmacological magnetic resonance imaging (phMRI) is the use of functional MRI techniques to elucidate the effects that psychotropic drugs have on neural activity within… (more)

▼ Pharmacological magnetic resonance imaging (phMRI) is the use of functional MRI techniques to elucidate the effects that psychotropic drugs have on neural activity within the brain; it is an emerging field of research that holds great potential for the investigation of drugs that act on the central nervous system by revealing the changes in neural activity that mediate observable changes in behavior, cognition, and perception. However, the realization of this potential is hampered by several unanswered questions: Are the MRI measurements reliable surrogates of changing neural activity in the presence of pharmacological agents? Is it relevant to investigate psychiatric phenomena such as reward or anxiolysis in anesthetized, rather than conscious animals? What are the methods that yield reproducible and meaningful results from phMRI experiments, and are they consistent in the investigations of different drugs? The research presented herein addresses many of these questions with the specific aims of 1) Developing pharmacological MRI methodologies that can be used in the conscious animal, 2) Validating these methodologies with the investigation of a non-stimulant, psychoactive compound, and 3) Applying these methodologies to the investigation of typical and atypical antipsychotic drugs, classes of compounds with unknown mechanisms of therapeutic action Building on recent developments in the field of functional MRI research, we developed new techniques that enable the investigator to measure localized changes in metabolism commensurate with changing neural activity. We tested the hypothesis that metabolic changes are a more reliable surrogate of changes in neural activity in response to a cocaine challenge, than changes observed in the blood-oxygen-level-dependent (BOLD) signal alone. We developed a system capable of multi-modal imaging in the conscious rat, and we tested the hypothesis that the conscious brain exhibits a markedly different response to systemic morphine challenge than the anesthetized brain. We identified and elucidated several fundamental limitations of the imaging and analysis protocols used in phMRI investigations, and developed new tools that enable the investigator to avoid common pitfalls. Finally, we applied these phMRI techniques to the investigation of neuroleptic compounds by asking the question: does treatment with typical or atypical antipsychotic drugs modulate the systems in the brain which are direct or indirect (i.e. downstream) substrates for a dopaminergic agonist? The execution of this research has generated several new tools for the neuroscience and drug discovery communities that can be used in neuropsychiatric investigations into the action of psychotropic drugs, while the results of this research provide evidence that supports several answers to the questions that currently limit the utility of phMRI investigations. Specifically, we observed that metabolic change can be measured to resolve discrepancies between anomalous BOLD signal… Advisors/Committee Members: Craig Ferris, Ph.D..

Subjects/Keywords: Psychotropic Drugs; Antipsychotic Agents; Magnetic Resonance Imaging; Rats; Animal Experimentation and Research; Chemical Actions and Uses; Diagnosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schmidt, K. F. (2006). Development of Pharmacological Magnetic Resonance Imaging Methods and their Application to the Investigation of Antipsychotic Drugs: a Dissertation. (Doctoral Dissertation). U of Massachusetts : Med. Retrieved from https://escholarship.umassmed.edu/gsbs_diss/114

Chicago Manual of Style (16^th Edition):

Schmidt, Karl F. “Development of Pharmacological Magnetic Resonance Imaging Methods and their Application to the Investigation of Antipsychotic Drugs: a Dissertation.” 2006. Doctoral Dissertation, U of Massachusetts : Med. Accessed April 20, 2021. https://escholarship.umassmed.edu/gsbs_diss/114.

MLA Handbook (7^th Edition):

Schmidt, Karl F. “Development of Pharmacological Magnetic Resonance Imaging Methods and their Application to the Investigation of Antipsychotic Drugs: a Dissertation.” 2006. Web. 20 Apr 2021.

Vancouver:

Schmidt KF. Development of Pharmacological Magnetic Resonance Imaging Methods and their Application to the Investigation of Antipsychotic Drugs: a Dissertation. [Internet] [Doctoral dissertation]. U of Massachusetts : Med; 2006. [cited 2021 Apr 20]. Available from: https://escholarship.umassmed.edu/gsbs_diss/114.

Council of Science Editors:

Schmidt KF. Development of Pharmacological Magnetic Resonance Imaging Methods and their Application to the Investigation of Antipsychotic Drugs: a Dissertation. [Doctoral Dissertation]. U of Massachusetts : Med; 2006. Available from: https://escholarship.umassmed.edu/gsbs_diss/114

University of Florida

25. Sun, Zhuming. Novel Phenylaminotetralin (PAT) Analogs Multifunctional Serotonin 5HT2 Receptor Drugs for Neuropsychiatric Disorders.

Degree: PhD, Pharmaceutical Sciences - Medicinal Chemistry, 2010, University of Florida

URL: https://ufdc.ufl.edu/UFE0042056

► NOVEL PHENYLAMINOTETRALIN (PAT) ANALOGS: MULTIFUNCTIONAL SEROTONIN 5HT2 RECEPTOR DRUGS FOR NEUROPSYCHIATRIC DISORDERS By Zhuming Sun August 2010 Chair: Raymond Booth Major: Pharmaceutical Science Medicinal Chemistry… (more)

▼ NOVEL PHENYLAMINOTETRALIN (PAT) ANALOGS: MULTIFUNCTIONAL SEROTONIN 5HT2 RECEPTOR DRUGS FOR NEUROPSYCHIATRIC DISORDERS By Zhuming Sun August 2010 Chair: Raymond Booth Major: Pharmaceutical Science Medicinal Chemistry This Ph.D. thesis research describes drug discovery targeting serotonin 5HT2 G protein-coupled receptor (GPCR) subtypes. Brain 5HT2C receptor activation in humans leads to anti-obesity effects, antipsychotic effects, attenuation of psychostimulant addiction, and other psychotherapeutic effects. Meanwhile, brain 5HT2A receptor activation produces hallucinogenic effects and activation of peripheral 5HT2B receptors produces cardiac valvulopathy and pulmonary hypertension. Until our recent publication, there was no report of a 5HT2C receptor agonist that does not also activate 5HT2A and/or 5HT2B receptors. Thus, clinical 5HT2C receptor-based pharmacotherapy was hampered. We reported (-)-trans-N,N-dimethyl-4-phenyl-1,2,3,4-tetrahydro-2-naphthalenamine (phenylaminotetralin; PAT) as a full-efficacy agonist at human 5HT2C receptors and inverse agonist at 5HT2A and 5HT2B receptors. In addition to selective activation of the 5HT2C receptor, the pharmacotherapeutic potential of (-)-trans-PAT is promising given that 5HT2A inverse agonists are used clinically as antipsychotic drugs. Thus, the general goals of these Ph.D. thesis studies included facile routes for scale-up synthesis of ( )-trans-PAT for preclinical in vivo studies in rodents, as well as, design and synthesis of PAT analogs with enhanced selective 5HT2C agonist potency and/or more potent 5HT2A and/or 5HT2B inverse agonist activity. In addition to development of pharmacotherapy for neuropsychiatric disorders and obesity, results are expected to help delineate 5HT2 GPCR structure and molecular requirements for activation for drug design purposes ( en ) Advisors/Committee Members: Booth, Raymond (committee chair), James, Margaret O. (committee member), Sloan, Kenneth B. (committee member), Morgan, Drake (committee member).

Subjects/Keywords: Agonists; Amines; Antipsychotic agents; Hexanes; Isomers; Ligands; Phenyls; Receptors; Serotonin receptors; Solvents; 5ht2c, agonist, neurodisorders

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sun, Z. (2010). Novel Phenylaminotetralin (PAT) Analogs Multifunctional Serotonin 5HT2 Receptor Drugs for Neuropsychiatric Disorders. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0042056

Chicago Manual of Style (16^th Edition):

Sun, Zhuming. “Novel Phenylaminotetralin (PAT) Analogs Multifunctional Serotonin 5HT2 Receptor Drugs for Neuropsychiatric Disorders.” 2010. Doctoral Dissertation, University of Florida. Accessed April 20, 2021. https://ufdc.ufl.edu/UFE0042056.

MLA Handbook (7^th Edition):

Sun, Zhuming. “Novel Phenylaminotetralin (PAT) Analogs Multifunctional Serotonin 5HT2 Receptor Drugs for Neuropsychiatric Disorders.” 2010. Web. 20 Apr 2021.

Vancouver:

Sun Z. Novel Phenylaminotetralin (PAT) Analogs Multifunctional Serotonin 5HT2 Receptor Drugs for Neuropsychiatric Disorders. [Internet] [Doctoral dissertation]. University of Florida; 2010. [cited 2021 Apr 20]. Available from: https://ufdc.ufl.edu/UFE0042056.

Council of Science Editors:

Sun Z. Novel Phenylaminotetralin (PAT) Analogs Multifunctional Serotonin 5HT2 Receptor Drugs for Neuropsychiatric Disorders. [Doctoral Dissertation]. University of Florida; 2010. Available from: https://ufdc.ufl.edu/UFE0042056

26. Stolker, J.J. Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings.

Degree: 2002, University Utrecht

URL: https://dspace.library.uu.nl/handle/1874/428 ; URN:NBN:NL:UI:10-1874-428 ; URN:NBN:NL:UI:10-1874-428 ; https://dspace.library.uu.nl/handle/1874/428

► The main objectives of this thesis were to establish the prevalence of psychotropic drug use as well as possible determinants associated with its use in… (more)

▼ The main objectives of this thesis were to establish the prevalence of psychotropic drug use as well as possible determinants associated with its use in multiple clinical settings: psychiatric admission wards, an intensive care unit and two settings for the intellectually disabled. In this thesis, we evaluated the question which class of antipsychotics is prescribed preferentially in newly admitted patients on psychiatric admission wards and the determinants affecting this decision. We found that the most frequently prescribed oral antipsychotic drugs were classical agents. Initial choice for short-acting parenteral classical antipsychotics was significantly associated with follow-up prescriptions of oral classical antipsychotics. We predict that upcoming introductions of short-acting parenteral formulations of atypical agents are likely to have a large impact on the subsequent oral antipsychotic treatment. In another study on psychiatric admission wards, we looked at the temporal relationship between the use of antipsychotics and seclusion. Antipsychotic treatment in patients with psychotic disorders was significantly associated with a delay of seclusion and, although not statistically significant, with a lower risk of seclusion. Furthermore, in a substantial proportion of the patients, antipsychotic therapy was only initiated during or directly following seclusion with a relative risk of 2.0 (95% confidence interval: 1.2-3.4). Our findings suggest that, in patients with psychotic disorders, not using antipsychotics is associated with aggression or violence for which seclusion is needed. Pharmacological treatment seems inevitable for a substantial proportion of secluded psychotic patients. Furthermore, we studied determinants of psychotropic drug use in a general intensive care unit (ICU). The prevalence of psychotropic drug use was 42.3%. Benzodiazepines were used in 35.8% of the patients, frequently at a high dosage. Antipsychotics were prescribed in 17.5% of all patients, typically in low dosages. The association of severe disease, a long ICU stay and an admission for non-surgical reasons with psychotropic drug use may be an indication that severely ill patients are likely to suffer from a delirium. In this study, patients who used psychotropic drugs (cases) acted as their own controls because days of drug exposure were compared to those of non-exposure and no corrections were made with the fact that observations were correlated. We compared this design with a logistical binomial model to adjust for correlated measures, or cluster effects through repeated measures and found that, although adjustment did not result in major changes in the odds ratios found, adjustment has greater effect with more observations per cluster. In a study in group homes for intellectually disabled residents, the point prevalence of psychotropic drug use in a problem behaviour group (PBG) was compared to a random group (RG) of residents and possible determinants of group membership were studied. Psychotropics were used by…

Subjects/Keywords: pharmacoepidemiology; drug utilization; psychotropic drugs; polypharmacy; antipsychotic agents; psychiatric hospitals; intensive care units; mental retardation; group homes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stolker, J. J. (2002). Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/428 ; URN:NBN:NL:UI:10-1874-428 ; URN:NBN:NL:UI:10-1874-428 ; https://dspace.library.uu.nl/handle/1874/428

Chicago Manual of Style (16^th Edition):

Stolker, J J. “Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings.” 2002. Doctoral Dissertation, University Utrecht. Accessed April 20, 2021. https://dspace.library.uu.nl/handle/1874/428 ; URN:NBN:NL:UI:10-1874-428 ; URN:NBN:NL:UI:10-1874-428 ; https://dspace.library.uu.nl/handle/1874/428.

MLA Handbook (7^th Edition):

Stolker, J J. “Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings.” 2002. Web. 20 Apr 2021.

Vancouver:

Stolker JJ. Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings. [Internet] [Doctoral dissertation]. University Utrecht; 2002. [cited 2021 Apr 20]. Available from: https://dspace.library.uu.nl/handle/1874/428 ; URN:NBN:NL:UI:10-1874-428 ; URN:NBN:NL:UI:10-1874-428 ; https://dspace.library.uu.nl/handle/1874/428.

Council of Science Editors:

Stolker JJ. Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings. [Doctoral Dissertation]. University Utrecht; 2002. Available from: https://dspace.library.uu.nl/handle/1874/428 ; URN:NBN:NL:UI:10-1874-428 ; URN:NBN:NL:UI:10-1874-428 ; https://dspace.library.uu.nl/handle/1874/428

27. EugÃnio de Moura Campos. Perfil cognitivo, ritmo e padrÃes do sono em pacientes portadores de esquizofrenia.

Degree: 2007, Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Farmacologia; UFC; BR

URL: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2710

► A esquizofrenia Ã uma doenÃa heterogÃnea quanto a caracterÃsticas e gravidade dos sintomas. Diversas alteraÃÃes relacionadas ao sono, com possÃveis efeitos sobre a capacidade funcional,… (more)

▼ A esquizofrenia Ã uma doenÃa heterogÃnea quanto a caracterÃsticas e gravidade dos sintomas. Diversas alteraÃÃes relacionadas ao sono, com possÃveis efeitos sobre a capacidade funcional, foram descritas. Dentre os poucos estudos que registraram ritmo circadiano na esquizofrenia, alguns sugerem que os indivÃduos com alteraÃÃes de ritmo apresentam menor rendimento em testes neuropsicolÃgicos. Os estudos neuropsicolÃgicos com pacientes esquizofrÃnicos dÃo conta de um comprometimento de diversos tipos de funÃÃes incluindo a memÃria operacional tanto verbal quanto viso-espacial. Muitos desses testes sÃo considerados longos e complicados e a utilidade de cada um deles ainda nÃo estÃ esclarecida. Este trabalho teve por objetivo: avaliar os padrÃes do sono, o cronotipo, o perfil neurocognitivo e as suas relaÃÃes com parÃmetros clÃnicos e funcionais. Trata-se de estudo observacional, transversal, de pacientes com esquizofrenia, em uso de antipsicÃticos convencionais ou de Ãltima geraÃÃo, quanto Ã capacidade funcional, alteraÃÃes do sono e perfil neurocognitivo. Foram utilizadas medidas para avaliaÃÃo da capacidade de funcionamento (Escala de AvaliaÃÃo Global do Funcionamento â AGF), gravidade das comorbidades (Cumulative Illness Rating Scale â CIRS), qualidade do sono (Ãndice de Qualidade de Sono de Pittsburgh â IQSP), sonolÃncia diurna (Escala de sonolÃncia de Epworth â ESE), cronotipo (QuestionÃrio de Horne e Ãstberg) e uma bateria de testes neurocognitivos incluindo os testes de Stroop, DÃgitos Direto e Indireto, Corsi Direto e Indireto e FluÃncia Verbal (CategÃrico). Foram estudados 82 pacientes (51,2% do sexo masculino) com idade entre 17 e 59 anos (35,2Â10,4) em uso de antipsicÃticos convencionais (N=22), olanzapina (N=30) ou risperidona (N=30). Observou-se mÃ-qualidade do sono (IQSP>5) em 41 (50%) e sonolÃncia excessiva diurna (ESE≥10) em 20 (24,4%) pacientes. A mÃ qualidade do sono associou-se com o gÃnero feminino (P=0,01). Uma tendÃncia de associaÃÃo entre a capacidade funcional e a qualidade do sono (P=0,07) foi registrada. Observou-se que a pior capacidade funcional associou-se com a idade mais avanÃada, um nÃmero reduzido de anos escolares e maior gravidade das comorbidades. Com relaÃÃo ao cronotipo e considerando o grupo total, 08 pacientes (9,8%) eram do tipo definitivamente vespertino, 39 (47,6%) eram do tipo moderadamente vespertino, 33 (40,2%) eram do tipo indiferente, dois (2,4%) eram moderadamente do tipo matutino e nenhum era definitivamente matutino. Os pacientes mais jovens e do sexo masculino apresentavam uma preferÃncia mais vespertina (F= 6,32; P= 0,01), de forma semelhante Ã populaÃÃo em geral. Os casos em uso de antipsicÃticos convencionais apresentaram uma tendÃncia para maior preferÃncia vespertina. As comorbidades mais frequentemente relatadas relacionaram-se a queixas osteoarticulares, sintomas psicolÃgicos e alteraÃÃes metabÃlicas. Os testes neurocognitivos apresentaram-se alterados na maioria dos casos, observando-se que a maioria dos pacientes apresentava escores inferiores a 80% dos… Advisors/Committee Members: Veralice Meireles Sales de Bruin, MÃnica Colares Oliveira Lima, JoÃo Ilo Coelho Barbosa, Acioly Luiz Tavares de Lacerda, Eliane Souto de Abreu.

Subjects/Keywords: Cronobiologia; CogniÃÃo; MemÃria; Testes NeuropsicolÃgicos.; Schizophrenia; Antipsychotic Agents; Sleep; Cronobiology; Cognition; Memory; Neuropsicological Tests.; PSIQUIATRIA

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Campos, E. d. M. (2007). Perfil cognitivo, ritmo e padrÃes do sono em pacientes portadores de esquizofrenia. (Doctoral Dissertation). Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Farmacologia; UFC; BR. Retrieved from http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2710

Chicago Manual of Style (16^th Edition):

Campos, EugÃnio de Moura. “Perfil cognitivo, ritmo e padrÃes do sono em pacientes portadores de esquizofrenia.” 2007. Doctoral Dissertation, Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Farmacologia; UFC; BR. Accessed April 20, 2021. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2710.

MLA Handbook (7^th Edition):

Campos, EugÃnio de Moura. “Perfil cognitivo, ritmo e padrÃes do sono em pacientes portadores de esquizofrenia.” 2007. Web. 20 Apr 2021.

Vancouver:

Campos EdM. Perfil cognitivo, ritmo e padrÃes do sono em pacientes portadores de esquizofrenia. [Internet] [Doctoral dissertation]. Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Farmacologia; UFC; BR; 2007. [cited 2021 Apr 20]. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2710.

Council of Science Editors:

Campos EdM. Perfil cognitivo, ritmo e padrÃes do sono em pacientes portadores de esquizofrenia. [Doctoral Dissertation]. Universidade Federal do CearÃ; Programa de PÃs-GraduaÃÃo em Farmacologia; UFC; BR; 2007. Available from: http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2710

28. Monica Kayo. Tempo de resposta a tratamento antipsicótico na esquizofrenia de início recente: um estudo randomizado e controlado de 12 semanas.

Degree: 2010, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-01022011-175641/

►

INTRODUÇÃO: Acredita-se cada vez mais que o tempo para se observar a resposta ao antipsicótico é curto, sendo possível nas primeiras duas semanas já prever… (more)

▼

INTRODUÇÃO: Acredita-se cada vez mais que o tempo para se observar a resposta ao antipsicótico é curto, sendo possível nas primeiras duas semanas já prever se o paciente responderá em 12 semanas. Entretanto, a maior parte das evidências que sustentam tal hipótese provém da análise de dados de estudos controlados duplo-cegos, que não definiam o conceito de início de ação de antipsicóticos, o que pode gerar uma certa confusão quanto às expectativas de resposta. Neste estudo, testamos se a ausência de melhora mínima de 20% da PANSS nas primeiras duas semanas correlacionava-se a ausência de resposta em 12 semanas. MÉTODOS: Foi feita a avaliação do tempo de resposta ao tratamento antipsicótico, utilizando o algoritmo de tratamento do IPAP, que recomenda o uso de monoterapia por 4 a 6 semanas, e troca por outro antipsicótico em caso de ausência de resposta. Os pacientes incluídos tinham esquizofrenia de início recente pelos critérios DSM-IV e foram aleatorizados para receber tratamento com antipsicótico de primeira geração (APG) ou de segunda geração (ASG). Foi considerada resposta ao tratamento a redução média de pelo menos 30% dos sintomas, em comparação com a PANSS inicial.Os pacientes foram avaliados pela PANSS a cada 2 semanas, durante 12 semanas. RESULTADOS: Foram incluídos 22 pacientes (APG, N=10 e ASG, N=12). Não houve diferença quanto ao tempo ou taxa de resposta entre os grupos; 20% (4) dos pacientes não responderam ao tratamento, enquanto 65% (13) responderam; 15% (3) abandonaram um tratamento. Um paciente não pôde ser avaliado pela PANSS e não teve seus dados incluídos na análise. Não houve correlação entre melhora nas primeiras 2 semanas e resposta em 12 semanas. A mudança média da 11 PANSS em relação ao basal foi significante a partir da 4a semana (p=0,43), e houve melhora progressiva ao longo das 12 semanas. Ambos os grupos tiveram a mesma proporção de substituições de medicamentos, sendo que não houve diferença, em termos de porcentagem de respondedores, entre os que trocaram o medicamento e entre os que permaneceram com a mesma medicação inicial. CONCLUSÕES: A ausência de resposta nas primeiras duas semanas não prediz ausência de resposta em 12 semanas. O tempo para avaliar a resposta clínica a um medicamento antipsicótico é de pelo menos quatro semanas. Aguardar o efeito do medicamento parece ser mais importante que trocar de medicamento nas primeiras 4 semanas

INTRODUCTION: It has been widely accepted that time to observe response to antipsychotic is short, with a response in 2 weeks predicting response or nonresponse in 12 weeks. However, most evidence for this hypothesis come from controlled doubleblind trials, which did not assess the onset of action, but clinical response, generating some false expectancies regarding clinical response. In this study, we assessed whether the lack of improvement in 2 weeks would predict nonresponse in 12 weeks. METHODS: We assessed time to response to antipsychotic through a treatment algorithm IPAP, which recommends monotherapy during 4-6 weeks and switch…

Advisors/Committee Members: Helio Elkis, Denise Razzouk, Paulo Clemente Sallet.

Subjects/Keywords: Agentes antipsicóticos; Algoritmo; Esquizofrenia; Tempo de resposta; Algorithm; Antipsychotic agents; Schizophrenia; Time to response

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kayo, M. (2010). Tempo de resposta a tratamento antipsicótico na esquizofrenia de início recente: um estudo randomizado e controlado de 12 semanas. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/5/5142/tde-01022011-175641/

Chicago Manual of Style (16^th Edition):

Kayo, Monica. “Tempo de resposta a tratamento antipsicótico na esquizofrenia de início recente: um estudo randomizado e controlado de 12 semanas.” 2010. Masters Thesis, University of São Paulo. Accessed April 20, 2021. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-01022011-175641/.

MLA Handbook (7^th Edition):

Kayo, Monica. “Tempo de resposta a tratamento antipsicótico na esquizofrenia de início recente: um estudo randomizado e controlado de 12 semanas.” 2010. Web. 20 Apr 2021.

Vancouver:

Kayo M. Tempo de resposta a tratamento antipsicótico na esquizofrenia de início recente: um estudo randomizado e controlado de 12 semanas. [Internet] [Masters thesis]. University of São Paulo; 2010. [cited 2021 Apr 20]. Available from: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-01022011-175641/.

Council of Science Editors:

Kayo M. Tempo de resposta a tratamento antipsicótico na esquizofrenia de início recente: um estudo randomizado e controlado de 12 semanas. [Masters Thesis]. University of São Paulo; 2010. Available from: http://www.teses.usp.br/teses/disponiveis/5/5142/tde-01022011-175641/

29. Nunes, Luciana Vargas Alves [UNIFESP]. A acurácia da Escala de Experiência Sexual do Arizona (ASEX) para identificar disfunção sexual em pacientes do espectro da esquizofrenia.

Degree: 2009, Universidade Federal de São Paulo (UNIFESP)

URL: http://repositorio.unifesp.br/handle/11600/8805

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Contexto: a disfunção sexual é frequente entre pacientes com esquizofrenia, sendo relatada como um dos mais incômodos efeitos adversos dos antipsicóticos e esta diretamente relacionada com adesão ao tratamento. Objetivo: a) avaliar a frequência da disfunção sexual em uma amostra de pacientes do espectro da esquizofrenia em tratamento com antipsicóticos; b) investigar 0 efeito dos diferentes antipsicóticos na função sexual; e c) avaliar a acurácia da Escala de Experiência Sexual do Arizona (AS EX) para identificar disfunção sexual. Método: pacientes ambulatoriais com esquizofrenia ou transtorno esquizoafetivo foram entrevistados através de questionários: ASEX e Escala Dickson-Glazer (DGSFi) para avaliação do funcionamento sexual, em uma única entrevista. Resultados: 137 pacientes foram entrevistados. A sensibilidade e especificidade da ASEX em relação a DGSFi foram: 80.8% ( 95% IC= 70.0%-88.5%) e 88.1 % (95% IC=76.5%-94.7%), e a taxa de classificação incorreta foi 9.5%. A curva ROC comparando a pontuação da ASEX e DGSFi revelou valor de 0.93 (IC=0.879¬0.970) com 0 ponto de corte da ASEX encontrando sendo 14/15. A disfunção sexual foi mais alta entre as mulheres (79.2%) do que nos homens (33.3%) (X2=27.41, gl=1, p<0.001). Conclusão: pacientes em tratamento com antipsicóticos mostraram alta frequência de queixas sexuais e ASEX provou ser um instrumento eficaz para identificar disfunção sexual em amostra de pacientes ambulatoriais do espectro da esquizofrenia. Mulheres mostraram frequência mais alta de disfunção, e desejo sexual e habilidade para alcançar orgasmo foram áreas mais afetadas. 0 uso de antipsicóticos, principal mente 0 uso de combinações, foi associado com piora do funcionamento sexual..

Background: sexual dysfunction is frequent in patients with schizophrenia, it is reported as one of the most distressing antipsychotic’s adverse effects and it is directly related to treatment compliance. Objective: a) to assess the frequency of sexual dysfunction in a sample of outpatients with schizophrenia and schizoaffective disorder under antipsychotic therapy; b) to investigate the effect of different antipsychotics on sexual function; and c) to evaluate the accuracy of the Arizona Sexual Experience Scale (ASEX) to identify sexual dysfunction. Method: Outpatients with schizophrenia or schizoaffective disorder were asked to fulfill both the ASEX and the Dickson Glazer Scale for the Assessment of Sexual Functioning Inventory (DGSFi) at a single interview. Results: 137 patients were interwied. The sensitivity and specificity of the ASEX in relation to DGSFi were: 80.8%, (95% CI= 70.0%-88.5%) and 88.1% (95% CI= 76.5%-94.7%), and the misclassification rate was 9.5%. The ROC curve comparing the ASEX and the DGSFi scores revealed a value of 0.93 (CI=…

Advisors/Committee Members: Universidade Federal de São Paulo (UNIFESP), Mari, Jair de Jesus [UNIFESP].

Subjects/Keywords: Esquizofrenia; Disfunção sexual fisiológica; Antipsicóticos; Schizophrenia; Sexual dysfunction; Antipsychotic Agents; ASEX; Sexual dysfunction, physiological

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nunes, L. V. A. [. (2009). A acurácia da Escala de Experiência Sexual do Arizona (ASEX) para identificar disfunção sexual em pacientes do espectro da esquizofrenia. (Masters Thesis). Universidade Federal de São Paulo (UNIFESP). Retrieved from http://repositorio.unifesp.br/handle/11600/8805

Chicago Manual of Style (16^th Edition):

Nunes, Luciana Vargas Alves [UNIFESP]. “A acurácia da Escala de Experiência Sexual do Arizona (ASEX) para identificar disfunção sexual em pacientes do espectro da esquizofrenia.” 2009. Masters Thesis, Universidade Federal de São Paulo (UNIFESP). Accessed April 20, 2021. http://repositorio.unifesp.br/handle/11600/8805.

MLA Handbook (7^th Edition):

Nunes, Luciana Vargas Alves [UNIFESP]. “A acurácia da Escala de Experiência Sexual do Arizona (ASEX) para identificar disfunção sexual em pacientes do espectro da esquizofrenia.” 2009. Web. 20 Apr 2021.

Vancouver:

Nunes LVA[. A acurácia da Escala de Experiência Sexual do Arizona (ASEX) para identificar disfunção sexual em pacientes do espectro da esquizofrenia. [Internet] [Masters thesis]. Universidade Federal de São Paulo (UNIFESP); 2009. [cited 2021 Apr 20]. Available from: http://repositorio.unifesp.br/handle/11600/8805.

Council of Science Editors:

Nunes LVA[. A acurácia da Escala de Experiência Sexual do Arizona (ASEX) para identificar disfunção sexual em pacientes do espectro da esquizofrenia. [Masters Thesis]. Universidade Federal de São Paulo (UNIFESP); 2009. Available from: http://repositorio.unifesp.br/handle/11600/8805

30. Stolker, J.J. Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings.

Degree: 2002, University Utrecht

URL: https://dspace.library.uu.nl/handle/1874/428 ; URN:NBN:NL:UI:10-1874-428 ; 1874/428 ; URN:NBN:NL:UI:10-1874-428 ; https://dspace.library.uu.nl/handle/1874/428

► The main objectives of this thesis were to establish the prevalence of psychotropic drug use as well as possible determinants associated with its use in… (more)

▼ The main objectives of this thesis were to establish the prevalence of psychotropic drug use as well as possible determinants associated with its use in multiple clinical settings: psychiatric admission wards, an intensive care unit and two settings for the intellectually disabled. In this thesis, we evaluated the question which class of antipsychotics is prescribed preferentially in newly admitted patients on psychiatric admission wards and the determinants affecting this decision. We found that the most frequently prescribed oral antipsychotic drugs were classical agents. Initial choice for short-acting parenteral classical antipsychotics was significantly associated with follow-up prescriptions of oral classical antipsychotics. We predict that upcoming introductions of short-acting parenteral formulations of atypical agents are likely to have a large impact on the subsequent oral antipsychotic treatment. In another study on psychiatric admission wards, we looked at the temporal relationship between the use of antipsychotics and seclusion. Antipsychotic treatment in patients with psychotic disorders was significantly associated with a delay of seclusion and, although not statistically significant, with a lower risk of seclusion. Furthermore, in a substantial proportion of the patients, antipsychotic therapy was only initiated during or directly following seclusion with a relative risk of 2.0 (95% confidence interval: 1.2-3.4). Our findings suggest that, in patients with psychotic disorders, not using antipsychotics is associated with aggression or violence for which seclusion is needed. Pharmacological treatment seems inevitable for a substantial proportion of secluded psychotic patients. Furthermore, we studied determinants of psychotropic drug use in a general intensive care unit (ICU). The prevalence of psychotropic drug use was 42.3%. Benzodiazepines were used in 35.8% of the patients, frequently at a high dosage. Antipsychotics were prescribed in 17.5% of all patients, typically in low dosages. The association of severe disease, a long ICU stay and an admission for non-surgical reasons with psychotropic drug use may be an indication that severely ill patients are likely to suffer from a delirium. In this study, patients who used psychotropic drugs (cases) acted as their own controls because days of drug exposure were compared to those of non-exposure and no corrections were made with the fact that observations were correlated. We compared this design with a logistical binomial model to adjust for correlated measures, or cluster effects through repeated measures and found that, although adjustment did not result in major changes in the odds ratios found, adjustment has greater effect with more observations per cluster. In a study in group homes for intellectually disabled residents, the point prevalence of psychotropic drug use in a problem behaviour group (PBG) was compared to a random group (RG) of residents and possible determinants of group membership were studied. Psychotropics were used by…

Subjects/Keywords: pharmacoepidemiology; drug utilization; psychotropic drugs; polypharmacy; antipsychotic agents; psychiatric hospitals; intensive care units; mental retardation; group homes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Stolker, J. J. (2002). Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings. (Doctoral Dissertation). University Utrecht. Retrieved from https://dspace.library.uu.nl/handle/1874/428 ; URN:NBN:NL:UI:10-1874-428 ; 1874/428 ; URN:NBN:NL:UI:10-1874-428 ; https://dspace.library.uu.nl/handle/1874/428

Chicago Manual of Style (16^th Edition):

Stolker, J J. “Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings.” 2002. Doctoral Dissertation, University Utrecht. Accessed April 20, 2021. https://dspace.library.uu.nl/handle/1874/428 ; URN:NBN:NL:UI:10-1874-428 ; 1874/428 ; URN:NBN:NL:UI:10-1874-428 ; https://dspace.library.uu.nl/handle/1874/428.

MLA Handbook (7^th Edition):

Stolker, J J. “Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings.” 2002. Web. 20 Apr 2021.

Vancouver:

Stolker JJ. Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings. [Internet] [Doctoral dissertation]. University Utrecht; 2002. [cited 2021 Apr 20]. Available from: https://dspace.library.uu.nl/handle/1874/428 ; URN:NBN:NL:UI:10-1874-428 ; 1874/428 ; URN:NBN:NL:UI:10-1874-428 ; https://dspace.library.uu.nl/handle/1874/428.

Council of Science Editors:

Stolker JJ. Struggles in prescribing : determinants of psychotropic drug use in multiple clinical settings. [Doctoral Dissertation]. University Utrecht; 2002. Available from: https://dspace.library.uu.nl/handle/1874/428 ; URN:NBN:NL:UI:10-1874-428 ; 1874/428 ; URN:NBN:NL:UI:10-1874-428 ; https://dspace.library.uu.nl/handle/1874/428

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