subject:(Animal diseases)

West Virginia University

1. Sommers, Karen Nicole. Immune related gene expression of parasite-resistant sheep during a Haemonchus contortus infection.

Degree: MS, Animal and Nutritional Sciences, 2014, West Virginia University

URL: https://doi.org/10.33915/etd.368 ; https://researchrepository.wvu.edu/etd/368

► Gastrointestinal nematode parasitism is a top health concern for sheep producers worldwide as traditional means of treatment are becoming less effective. Haemonchus contortus is of… (more)

Subjects/Keywords: Animal diseases; Animal sciences

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APA (6^th Edition):

Sommers, K. N. (2014). Immune related gene expression of parasite-resistant sheep during a Haemonchus contortus infection. (Thesis). West Virginia University. Retrieved from https://doi.org/10.33915/etd.368 ; https://researchrepository.wvu.edu/etd/368

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sommers, Karen Nicole. “Immune related gene expression of parasite-resistant sheep during a Haemonchus contortus infection.” 2014. Thesis, West Virginia University. Accessed March 08, 2021. https://doi.org/10.33915/etd.368 ; https://researchrepository.wvu.edu/etd/368.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sommers, Karen Nicole. “Immune related gene expression of parasite-resistant sheep during a Haemonchus contortus infection.” 2014. Web. 08 Mar 2021.

Vancouver:

Sommers KN. Immune related gene expression of parasite-resistant sheep during a Haemonchus contortus infection. [Internet] [Thesis]. West Virginia University; 2014. [cited 2021 Mar 08]. Available from: https://doi.org/10.33915/etd.368 ; https://researchrepository.wvu.edu/etd/368.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sommers KN. Immune related gene expression of parasite-resistant sheep during a Haemonchus contortus infection. [Thesis]. West Virginia University; 2014. Available from: https://doi.org/10.33915/etd.368 ; https://researchrepository.wvu.edu/etd/368

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

2. Castle, Brittany Amber. Survey of Swine Disease, Management and Biosecurity Practices of Hawai'i Swine Farms.

Degree: 2019, University of Hawai'i at Manoa

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10977266

► Although swine diseases and parasites cause significant losses to producers in Hawai‘i, limited information is available on changing disease patterns and related farm practices.… (more)

Subjects/Keywords: Agriculture; Animal sciences; Animal diseases

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APA (6^th Edition):

Castle, B. A. (2019). Survey of Swine Disease, Management and Biosecurity Practices of Hawai'i Swine Farms. (Thesis). University of Hawai'i at Manoa. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10977266

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Castle, Brittany Amber. “Survey of Swine Disease, Management and Biosecurity Practices of Hawai'i Swine Farms.” 2019. Thesis, University of Hawai'i at Manoa. Accessed March 08, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=10977266.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Castle, Brittany Amber. “Survey of Swine Disease, Management and Biosecurity Practices of Hawai'i Swine Farms.” 2019. Web. 08 Mar 2021.

Vancouver:

Castle BA. Survey of Swine Disease, Management and Biosecurity Practices of Hawai'i Swine Farms. [Internet] [Thesis]. University of Hawai'i at Manoa; 2019. [cited 2021 Mar 08]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10977266.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Castle BA. Survey of Swine Disease, Management and Biosecurity Practices of Hawai'i Swine Farms. [Thesis]. University of Hawai'i at Manoa; 2019. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10977266

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Purdue University

3. Fardisi, Mahsa. Investigation of dried distillers grains with solubles (DDGS) susceptibility to red flour beetle (Tribolium castaneum (Herbst)) infestation.

Degree: PhD, Entomology, 2015, Purdue University

URL: https://docs.lib.purdue.edu/open_access_dissertations/510

► Protecting livestock feed from insect infestation is a common challenge that feed facility managers and farmers have to deal with. It becomes an issue… (more)

▼ Protecting livestock feed from insect infestation is a common challenge that feed facility managers and farmers have to deal with. It becomes an issue of importance because insect infestation degrades feed quality and quantity. Dried Distillers Grains with Solubles (DDGS) is added to livestock feed because of its high protein content. As DDGS usage in animal feed increases, understanding the susceptibility of DDGS, when mixed with livestock feed, to insect infestation is necessary for safe feed storage. This research addressed four questions. The first looked at the susceptibility of DDGS, when stored as a raw ingredient, to Tribolium castaneum (Herbst) infestation. DDGS susceptibility to T. castaneum was lower when stored as a raw ingredient compared with normal T. castaneum laboratory diet at 30% r.h.. However, increasing r.h. to 50% and grinding DDGS samples, increased DDGS susceptibility to T. castaneum infestation. The second question concerned the susceptibility of livestock feed that contains DDGS to T. castaneum infestation. Results showed that adding any amount of DDGS to animal feed will not change diet susceptibility to T. castaneum infestation and feed pelletization negatively affected insect development. For the third question, experiments were conducted to determine the chemical and physical characteristics of DDGS which may influence its susceptibility to T. castaneum infestation. Particle size was the main factor affecting DDGS vulnerability to T. castaneum infestation. The fourth question focused on the alternative uses of DDGS as bait for monitoring T. castaneum. Efficacy of traps significantly increased when a combination of DDGS and food oil kairomone lures were used compared with food oil or empty traps. Therefore, DDGS may be a good additive to food oil lures to increase trap efficacy. In conclusion, T. castaneum development significantly increased when fed DDGS. Diet particle size and environmental humidity had significant effects on T. castaneum development. As a result, it is recommended that facility managers store DDGS as a raw ingredient, pelletize DDGS if it is cost-effective, and keep the storage humidity at 30% or lower. Advisors/Committee Members: Linda Mason, Klein Ileleji, Linda Mason, Michael Scharf, Douglas Richmond, Olayiwola Adeola.

Subjects/Keywords: Animal Diseases; Animal Sciences; Entomology

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APA (6^th Edition):

Fardisi, M. (2015). Investigation of dried distillers grains with solubles (DDGS) susceptibility to red flour beetle (Tribolium castaneum (Herbst)) infestation. (Doctoral Dissertation). Purdue University. Retrieved from https://docs.lib.purdue.edu/open_access_dissertations/510

Chicago Manual of Style (16^th Edition):

Fardisi, Mahsa. “Investigation of dried distillers grains with solubles (DDGS) susceptibility to red flour beetle (Tribolium castaneum (Herbst)) infestation.” 2015. Doctoral Dissertation, Purdue University. Accessed March 08, 2021. https://docs.lib.purdue.edu/open_access_dissertations/510.

MLA Handbook (7^th Edition):

Fardisi, Mahsa. “Investigation of dried distillers grains with solubles (DDGS) susceptibility to red flour beetle (Tribolium castaneum (Herbst)) infestation.” 2015. Web. 08 Mar 2021.

Vancouver:

Fardisi M. Investigation of dried distillers grains with solubles (DDGS) susceptibility to red flour beetle (Tribolium castaneum (Herbst)) infestation. [Internet] [Doctoral dissertation]. Purdue University; 2015. [cited 2021 Mar 08]. Available from: https://docs.lib.purdue.edu/open_access_dissertations/510.

Council of Science Editors:

Fardisi M. Investigation of dried distillers grains with solubles (DDGS) susceptibility to red flour beetle (Tribolium castaneum (Herbst)) infestation. [Doctoral Dissertation]. Purdue University; 2015. Available from: https://docs.lib.purdue.edu/open_access_dissertations/510

Washington State University

4. [No author]. CONTRIBUTION OF SALMONELLA ENTERITIDIS VIRULENCE FACTORS TO INTESTINAL COLONIZATION AND SYSTEMIC DISSEMINATION IN DAY-OLD CHICKENS .

Degree: 2013, Washington State University

URL: http://hdl.handle.net/2376/5129

► Salmonella enterica serovar Enteritidis (S. Enteritidis) is one of the most common serovars associated with poultry and poultry product contamination in the USA. We previously… (more)

Subjects/Keywords: Microbiology; Animal diseases

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APA (6^th Edition):

author], [. (2013). CONTRIBUTION OF SALMONELLA ENTERITIDIS VIRULENCE FACTORS TO INTESTINAL COLONIZATION AND SYSTEMIC DISSEMINATION IN DAY-OLD CHICKENS . (Thesis). Washington State University. Retrieved from http://hdl.handle.net/2376/5129

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “CONTRIBUTION OF SALMONELLA ENTERITIDIS VIRULENCE FACTORS TO INTESTINAL COLONIZATION AND SYSTEMIC DISSEMINATION IN DAY-OLD CHICKENS .” 2013. Thesis, Washington State University. Accessed March 08, 2021. http://hdl.handle.net/2376/5129.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “CONTRIBUTION OF SALMONELLA ENTERITIDIS VIRULENCE FACTORS TO INTESTINAL COLONIZATION AND SYSTEMIC DISSEMINATION IN DAY-OLD CHICKENS .” 2013. Web. 08 Mar 2021.

Vancouver:

author] [. CONTRIBUTION OF SALMONELLA ENTERITIDIS VIRULENCE FACTORS TO INTESTINAL COLONIZATION AND SYSTEMIC DISSEMINATION IN DAY-OLD CHICKENS . [Internet] [Thesis]. Washington State University; 2013. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/2376/5129.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. CONTRIBUTION OF SALMONELLA ENTERITIDIS VIRULENCE FACTORS TO INTESTINAL COLONIZATION AND SYSTEMIC DISSEMINATION IN DAY-OLD CHICKENS . [Thesis]. Washington State University; 2013. Available from: http://hdl.handle.net/2376/5129

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Missouri – Columbia

5. Gilliam, Douglas H., Jr., 1983-. Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy.

Degree: 2016, University of Missouri – Columbia

URL: https://doi.org/10.32469/10355/56525

► The genome of Canis lupus familiaris, the domestic dog, is an ideal tool for the study of inherited diseases. Its genome is uniquely suited for… (more)

▼ The genome of Canis lupus familiaris, the domestic dog, is an ideal tool for the study of inherited diseases. Its genome is uniquely suited for the mapping of genes that cause disease, and its reference genome has been published since 2008. Dogs and humans share many of the same diseases, making them an ideal model for the study of comparative genetics. The identification of disease-causing genes in dogs has relevance to human health. We here describe the identification of causal mutations for three different canine diseases in orthologs of genes with orthologous human diseases. We used Next Generation Sequencing in order to generate Whole Genome Sequences for 145 dogs from 69 different breeds with various inherited canine diseases, most of which were suspected to be inherited recessively. We here report the discovery of the causes of; Spinocerebellar Ataxia with Myokymia and Seizures in Russell-Group Terriers, Neuronal Ceroid Lipofuscinosis in Golden Retrievers and Dilated Cardiomyopathy in Standard Schnauzers. While all three were identified via whole genome sequencing, different methodologies and techniques were used to discover and validate the findings. We discuss the importance of these studies and suggest future studies for the projects as well as possible other means of discovering potential canine disease models via Whole Genome Sequencing. Summaries of these three findings are provided in the next three paragraphs. Juvenile-onset spinocerebellar ataxia has been recognized in Jack Russell Terriers and related Russell group terriers (RGTs) for over 40 years. Ataxia occurs with varying combinations of myokymia, seizures and other signs, thus more than one form of the disease has been suspected. Our objective was to identify the mutation causing the spinocerebellar ataxia associated with myokymia and/or seizures and distinguish the phenotype from other ataxias seen in the RGTs. We collected DNA samples from 16 RGTs with signs of spinocerebellar ataxia beginning from 2-to-12 months of age, 640 control RGTs, and 383 dogs from 144 other breeds along with the medical records of affected dogs in order to elucidate the genetic cause of this disease. Whole-genome sequencing was performed on one RGT with ataxia and myokymia. Unique, homozygous variants were identified in this dog by comparing its sequence to whole-genome sequences from 81 other canids. We found a missense mutation in the gene coding for the inward rectifying potassium channel Kir4.1 (KCNJ10:c.627C>G) that was significantly associated with the disease. Dogs homozygous for the mutant allele all showed spinocerebellar ataxia with varying combinations of myokymia, seizures and other signs. The identification of a mutation in KCNJ10 in dogs with spinocerebellar ataxia with myokymia and/or seizures (SAMS) clarifies the multiple forms of ataxia seen in these breeds and provides a DNA test to identify carriers. Understanding the role the Kir4.1 channel plays in extracellular potassium buffering by astrocytes could shed light on other conditions characterized… Advisors/Committee Members: Johnson, Gary S., 1943- (advisor).

Subjects/Keywords: Dogs – Diseases – Genetic aspects; Diseases – Animal models

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APA (6^th Edition):

Gilliam, Douglas H., Jr., 1. (2016). Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy. (Thesis). University of Missouri – Columbia. Retrieved from https://doi.org/10.32469/10355/56525

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gilliam, Douglas H., Jr., 1983-. “Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy.” 2016. Thesis, University of Missouri – Columbia. Accessed March 08, 2021. https://doi.org/10.32469/10355/56525.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gilliam, Douglas H., Jr., 1983-. “Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy.” 2016. Web. 08 Mar 2021.

Vancouver:

Gilliam, Douglas H., Jr. 1. Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy. [Internet] [Thesis]. University of Missouri – Columbia; 2016. [cited 2021 Mar 08]. Available from: https://doi.org/10.32469/10355/56525.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gilliam, Douglas H., Jr. 1. Molecular genetic studies of canine inherited diseases including SAMS, neuronal ceroid lipofuscinosis and dilated cardiomyopathy: Molecular genetic studies of canine inherited diseases including spinocerebellar ataxia with myokymia and seizures, neuronal ceroid lipofuscinosis and dilated cardiomyopathy. [Thesis]. University of Missouri – Columbia; 2016. Available from: https://doi.org/10.32469/10355/56525

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Washington State University

6. Santo, James Talbot. Environmental and Biological Stressors in Relation to Honey Bee Colony Collapse.

Degree: 2018, Washington State University

URL: http://pqdtopen.proquest.com/#viewpdf?dispub=10786928

► Over the last several decades declines in pollinator populations, especially those of wild bees and other insects, have raised awareness of the economic impact… (more)

▼ Over the last several decades declines in pollinator populations, especially those of wild bees and other insects, have raised awareness of the economic impact pollination services have for crop production. This awareness and concern was heightened by an ongoing loss of millions of managed honey bee colonies since the early 1950s. Colonies are used predominantly for pollination services in fruit and vegetable crops. During 2007, an unusually large overwintering loss in colonies that was not characterized by the presence of dead bees was termed colony collapse disorder (CCD), a syndrome in which hives lacked sufficient worker caste bees to maintain the queen and brood. Potential factors hypothesized to be associated with CCD include parasite infestations (e.g., Varroa mite) and pathogen infections (Nosema spp. fungus and viruses), insecticide exposure (especially to the neonicotinoid class), and poor nutrition owing to a reduction in landscape areas containing high quality floral resources. Although no one stressor has been definitively associated with CCD, possible interactions among them have only recently been studied. Of particular interest are possible interactions of Nosema spp. with neonicotinoid insecticide exposure. The main objective of this dissertation was an examination of these potential interactions using a combination of literature analysis, empirical study of Nosema infection prevalence in adult bees, and simulation modeling of the combined effects of several stressors on worker population abundance. After the introduction, the dissertation is divided into four chapters addressing the following objectives: (1) Comparison of regulatory procedures for risk assessment of insecticides potentially impacting honey bees in the United States and in the European Union; (2) Analysis of published literature that document potential interactions between bee pathogens, parasites, and neonicotinoid insecticide residues; (3) Analysis of field-collected apiary bees for prevalence of Nosema spores in association with land uses and the presence of neonicotinoid residues; (4) Use of the honey bee colony model BEEHAVE to predict colony collapse in the presence of pathogens and insecticide-induced mortality. Results of the various analyses suggest a need for modifying risk assessment procedures to include the interaction of pesticide residues with parasite/pathogen stressors.

Subjects/Keywords: Toxicology; Animal diseases; Environmental science

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APA (6^th Edition):

Santo, J. T. (2018). Environmental and Biological Stressors in Relation to Honey Bee Colony Collapse. (Thesis). Washington State University. Retrieved from http://pqdtopen.proquest.com/#viewpdf?dispub=10786928

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Santo, James Talbot. “Environmental and Biological Stressors in Relation to Honey Bee Colony Collapse.” 2018. Thesis, Washington State University. Accessed March 08, 2021. http://pqdtopen.proquest.com/#viewpdf?dispub=10786928.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Santo, James Talbot. “Environmental and Biological Stressors in Relation to Honey Bee Colony Collapse.” 2018. Web. 08 Mar 2021.

Vancouver:

Santo JT. Environmental and Biological Stressors in Relation to Honey Bee Colony Collapse. [Internet] [Thesis]. Washington State University; 2018. [cited 2021 Mar 08]. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10786928.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Santo JT. Environmental and Biological Stressors in Relation to Honey Bee Colony Collapse. [Thesis]. Washington State University; 2018. Available from: http://pqdtopen.proquest.com/#viewpdf?dispub=10786928

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

West Virginia University

7. Mantha, Kameswari Sirisha. A poultry litter marker gene correlates with pathogen and indicator bacteria deposition on, growth in and transport from poultry bedding.

Degree: MS, Civil and Environmental Engineering, 2014, West Virginia University

URL: https://doi.org/10.33915/etd.113 ; https://researchrepository.wvu.edu/etd/113

► Poultry is one of the major contributors of inputs to U.S. environmental waters due to the large number of poultry grown per year in the… (more)

▼ Poultry is one of the major contributors of inputs to U.S. environmental waters due to the large number of poultry grown per year in the U.S. and litter disposal practices. Two studies were conducted during this research: (1) to determine the temporal rate of deposition and growth or decay of microorganisms in poultry litter originating from poultry feces and (2) the release and transport of poultry litter associated microorganisms from soiled poultry litter applied as fertilizer through soil columns under simulated rainfall. First, deposition studies were conducted to evaluate the deposition rate of microorganisms on poultry bedding during the growth of poultry. The studies were designed to simultaneously evaluate the growth or decay of microorganisms after deposition on the poultry bedding (i.e., wood shavings). A secondary objective of this study was to determine if there is a correlation between the poultry litter marker gene and indicator bacteria (FIB) and pathogens during deposition. Culture and qPCR analysis revealed growth of Enterococcus, Staphylococcus and Bacteroidales in the litter for up to four weeks after deposition in feces. In contrast after deposition of E. coli on the litter, the concentrations of E. coli declined after the soiled litter was separated from the poultry. The poultry litter marker Brevibacterium sp. LA35 was found to increase in the litter over time as the birds aged, but was not observed to grow in the soiled litter after deposition with feces. The deposition study aids in our understanding of the deposition, survival and growth of microorganisms from poultry feces in and on poultry litter. The next study conducted evaluated the release and transport of pathogens (Salmonella sp.), FIB (Enterococcus, and E. coli) and MST markers (LA35 and Bacteroidales) from poultry litter under simulated rainfall events through soil columns. The transport and attenuation of microorganisms was observed through an acid washed sand column and loamy sand soil columns over 10 to 30 pore volumes of deionized water. The qPCR analysis revealed that the breakthrough of pathogens and MST markers were correlated. These soil column studies aid in our understanding of the release, transport and attenuation of pathogens from poultry litter applied as an agricultural fertilizer. Advisors/Committee Members: Jennifer Weidhaas, Antarpreet S. Jutla, Alan J. Sexstone.

Subjects/Keywords: Microbiology; Environmental engineering; Animal diseases

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APA (6^th Edition):

Mantha, K. S. (2014). A poultry litter marker gene correlates with pathogen and indicator bacteria deposition on, growth in and transport from poultry bedding. (Thesis). West Virginia University. Retrieved from https://doi.org/10.33915/etd.113 ; https://researchrepository.wvu.edu/etd/113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mantha, Kameswari Sirisha. “A poultry litter marker gene correlates with pathogen and indicator bacteria deposition on, growth in and transport from poultry bedding.” 2014. Thesis, West Virginia University. Accessed March 08, 2021. https://doi.org/10.33915/etd.113 ; https://researchrepository.wvu.edu/etd/113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mantha, Kameswari Sirisha. “A poultry litter marker gene correlates with pathogen and indicator bacteria deposition on, growth in and transport from poultry bedding.” 2014. Web. 08 Mar 2021.

Vancouver:

Mantha KS. A poultry litter marker gene correlates with pathogen and indicator bacteria deposition on, growth in and transport from poultry bedding. [Internet] [Thesis]. West Virginia University; 2014. [cited 2021 Mar 08]. Available from: https://doi.org/10.33915/etd.113 ; https://researchrepository.wvu.edu/etd/113.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mantha KS. A poultry litter marker gene correlates with pathogen and indicator bacteria deposition on, growth in and transport from poultry bedding. [Thesis]. West Virginia University; 2014. Available from: https://doi.org/10.33915/etd.113 ; https://researchrepository.wvu.edu/etd/113

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

College of William and Mary

8. Pitman, John Mathews. The existence and nature of hypothyroidism in reproductively inhibited prairie deermice (Peromyscus maniculatus bairdi) from laboratory populations.

Degree: MA, Biology, 1983, College of William and Mary

URL: https://scholarworks.wm.edu/etd/1539625212

Subjects/Keywords: Animal Diseases

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APA (6^th Edition):

Pitman, J. M. (1983). The existence and nature of hypothyroidism in reproductively inhibited prairie deermice (Peromyscus maniculatus bairdi) from laboratory populations. (Masters Thesis). College of William and Mary. Retrieved from https://scholarworks.wm.edu/etd/1539625212

Chicago Manual of Style (16^th Edition):

Pitman, John Mathews. “The existence and nature of hypothyroidism in reproductively inhibited prairie deermice (Peromyscus maniculatus bairdi) from laboratory populations.” 1983. Masters Thesis, College of William and Mary. Accessed March 08, 2021. https://scholarworks.wm.edu/etd/1539625212.

MLA Handbook (7^th Edition):

Pitman, John Mathews. “The existence and nature of hypothyroidism in reproductively inhibited prairie deermice (Peromyscus maniculatus bairdi) from laboratory populations.” 1983. Web. 08 Mar 2021.

Vancouver:

Pitman JM. The existence and nature of hypothyroidism in reproductively inhibited prairie deermice (Peromyscus maniculatus bairdi) from laboratory populations. [Internet] [Masters thesis]. College of William and Mary; 1983. [cited 2021 Mar 08]. Available from: https://scholarworks.wm.edu/etd/1539625212.

Council of Science Editors:

Pitman JM. The existence and nature of hypothyroidism in reproductively inhibited prairie deermice (Peromyscus maniculatus bairdi) from laboratory populations. [Masters Thesis]. College of William and Mary; 1983. Available from: https://scholarworks.wm.edu/etd/1539625212

Washington State University

9. [No author]. Growth of Mannheimia haemolytica:Inhibitory agents and putative mechanism of inhibition .

Degree: 2014, Washington State University

URL: http://hdl.handle.net/2376/5403

► Pneumonia is the most important disease of bighorn sheep (BHS). Pathogens detected in pneumonic BHS lungs include Mannheimia haemolytica, Bibersteinia trehalosi, Pasteurella multocida and Mycoplasma… (more)

▼ Pneumonia is the most important disease of bighorn sheep (BHS). Pathogens detected in pneumonic BHS lungs include Mannheimia haemolytica, Bibersteinia trehalosi, Pasteurella multocida and Mycoplasma ovipneumoniae. Although leukotoxin-producing M. haemolytica consistently causes fatal pneumonia in BHS under experimental conditions, B. trehalosi and P. multocida are isolated more frequently than M. haemolytica from pneumonic BHS lungs by culture. In this study, I extended the previous findings from our laboratory that B. trehalosi and P. multocida inhibit the growth of M. haemolytica. I hypothesized that the inhibitory phenotype of B. trehalosi is conserved across B. trehalosi strains. Fifty-five B. trehalosi isolates were tested by bacterial competition assays. All of them inhibited M. haemolytica suggesting that the inhibitory phenotype is conserved. No plasmids were isolated from any of the 30 B. trehalosi isolates tested, suggesting that the effectors are chromosomally-encoded. The observation that M. haemolytica was not isolated frequently even from pneumonic BHS lungs that did not carry B. trehalosi or P. multocida led to my second hypothesis that bacteria other than B. trehalosi and P. multocida inhibit the growth of M. haemolytica. Bacterial competition assays showed that Escherichia coli also inhibits the growth of M. haemolytica via a proximity-dependent mechanism. Streptococcus spp. and Staphylococcus spp. did not have any inhibitory effect. Fatal pneumonia in BHS often results from acquisition of leukotoxin-positive M. haemolytica from domestic sheep (DS). I hypothesized that intranasal inoculation of B. trehalosi will eliminate or reduce shedding of M. haemolytica by DS. Domestic sheep were oro-nasally inoculated with B. trehalosi following antibiotic treatment. These DS shed reduced numbers of M. haemolytica than un-treated DS. However, healthy BHS commingled with B. trehalosi-treated DS acquired M. haemolytica around day 14 post-commingling which resulted in the development of leukotoxin-neutralizing antibodies. They did not develop pneumonia for 211 days. However, they died of pneumonia when commingled with DS that carried leukotoxin-positive M. haemolytica, B. trehalosi and M. ovipneumoniae. These findings suggest that B. trehalosi can be used to reduce the shedding of M. haemolytica by DS. However, infection with leukotoxin-positive M. haemolytica, B. trehalosi and M. ovipneumoniae synergistically causes fatal pneumonia in BHS. Advisors/Committee Members: Srikumaran, Subramaniam (advisor).

Subjects/Keywords: Microbiology; Immunology; Animal diseases

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APA (6^th Edition):

author], [. (2014). Growth of Mannheimia haemolytica:Inhibitory agents and putative mechanism of inhibition . (Thesis). Washington State University. Retrieved from http://hdl.handle.net/2376/5403

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “Growth of Mannheimia haemolytica:Inhibitory agents and putative mechanism of inhibition .” 2014. Thesis, Washington State University. Accessed March 08, 2021. http://hdl.handle.net/2376/5403.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “Growth of Mannheimia haemolytica:Inhibitory agents and putative mechanism of inhibition .” 2014. Web. 08 Mar 2021.

Vancouver:

author] [. Growth of Mannheimia haemolytica:Inhibitory agents and putative mechanism of inhibition . [Internet] [Thesis]. Washington State University; 2014. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/2376/5403.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. Growth of Mannheimia haemolytica:Inhibitory agents and putative mechanism of inhibition . [Thesis]. Washington State University; 2014. Available from: http://hdl.handle.net/2376/5403

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Iowa State University

10. Lewis, Charles Elliott. Biosurveillance utilizing engorged ticks as phlebotomists for xenodiagnosis.

Degree: 2018, Iowa State University

URL: https://lib.dr.iastate.edu/etd/16617

► Emerging infectious diseases pose a global threat to both human and animal health. The majority of novel zoonotic pathogens occur along the interface between humans,… (more)

Subjects/Keywords: Animal Diseases; Microbiology; Veterinary Medicine

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APA (6^th Edition):

Lewis, C. E. (2018). Biosurveillance utilizing engorged ticks as phlebotomists for xenodiagnosis. (Thesis). Iowa State University. Retrieved from https://lib.dr.iastate.edu/etd/16617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lewis, Charles Elliott. “Biosurveillance utilizing engorged ticks as phlebotomists for xenodiagnosis.” 2018. Thesis, Iowa State University. Accessed March 08, 2021. https://lib.dr.iastate.edu/etd/16617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lewis, Charles Elliott. “Biosurveillance utilizing engorged ticks as phlebotomists for xenodiagnosis.” 2018. Web. 08 Mar 2021.

Vancouver:

Lewis CE. Biosurveillance utilizing engorged ticks as phlebotomists for xenodiagnosis. [Internet] [Thesis]. Iowa State University; 2018. [cited 2021 Mar 08]. Available from: https://lib.dr.iastate.edu/etd/16617.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lewis CE. Biosurveillance utilizing engorged ticks as phlebotomists for xenodiagnosis. [Thesis]. Iowa State University; 2018. Available from: https://lib.dr.iastate.edu/etd/16617

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Maryland

11. Harrison, Arthur Pennoyer. Bacteria as secondary invaders in blackhead livers of turkeys.

Degree: 1952, University of Maryland

URL: http://hdl.handle.net/1903/17710

Subjects/Keywords: Animal diseases

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APA (6^th Edition):

Harrison, A. P. (1952). Bacteria as secondary invaders in blackhead livers of turkeys. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/17710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Harrison, Arthur Pennoyer. “Bacteria as secondary invaders in blackhead livers of turkeys.” 1952. Thesis, University of Maryland. Accessed March 08, 2021. http://hdl.handle.net/1903/17710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Harrison, Arthur Pennoyer. “Bacteria as secondary invaders in blackhead livers of turkeys.” 1952. Web. 08 Mar 2021.

Vancouver:

Harrison AP. Bacteria as secondary invaders in blackhead livers of turkeys. [Internet] [Thesis]. University of Maryland; 1952. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/1903/17710.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Harrison AP. Bacteria as secondary invaders in blackhead livers of turkeys. [Thesis]. University of Maryland; 1952. Available from: http://hdl.handle.net/1903/17710

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Maryland

12. Tepper, Albert Edward. Studies on gizzard ulceration in chickens.

Degree: 1941, University of Maryland

URL: http://hdl.handle.net/1903/17952

Subjects/Keywords: Animal diseases

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APA (6^th Edition):

Tepper, A. E. (1941). Studies on gizzard ulceration in chickens. (Thesis). University of Maryland. Retrieved from http://hdl.handle.net/1903/17952

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tepper, Albert Edward. “Studies on gizzard ulceration in chickens.” 1941. Thesis, University of Maryland. Accessed March 08, 2021. http://hdl.handle.net/1903/17952.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tepper, Albert Edward. “Studies on gizzard ulceration in chickens.” 1941. Web. 08 Mar 2021.

Vancouver:

Tepper AE. Studies on gizzard ulceration in chickens. [Internet] [Thesis]. University of Maryland; 1941. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/1903/17952.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tepper AE. Studies on gizzard ulceration in chickens. [Thesis]. University of Maryland; 1941. Available from: http://hdl.handle.net/1903/17952

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

The Ohio State University

13. Dodson, Kathryn Kristine. Transfer Frequency of CMY-2-Encoding Plasmids Among Fecal Flora of Pigs.

Degree: MS, Veterinary Preventive Medicine, 2005, The Ohio State University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=osu1395851225

► Plasmid-encoded CMY-2, an AmpC-like ß-lactamase, has disseminated rapidly worldwide and conveys resistance to a wide variety of antibiotics. CMY-2 was used as a model system… (more)

▼ Plasmid-encoded CMY-2, an AmpC-like ß-lactamase, has disseminated rapidly worldwide and conveys resistance to a wide variety of antibiotics. CMY-2 was used as a model system to study the in vitro fitness and the in vivo persistence and conjugal transfer rates of antibiotic resistance genes.In vitro: CMY-2-encoding plasmid DNA was electroporated into E. coli DH10B. Two large plasmids (>194 kb) transferred resistance to cefoxitin, cephalothin, tetracycline, and ampicillin and intermediate resistance to ceftriaxone and ceftiofur to E. coli DH10B. The growth curves of the transformed and non-transformed E. coli DH10B were very similar. Filter mating of the transformed E. coli DH10B with three unique Salmonella strains did not result in transconjugants, regardless of variation in donor: recipient ratios, incubation temperature, and enrichment. The CMY-2-encoding plasmid does not convey a significant metabolic burden to the host bacteria and is not readily transferred between bacteria in vitro.Challenge 1: Ten weaned, three-week-old pigs were randomly assigned to two groups. The first group of five pigs was orally inoculated with CMY-2-containing Salmonella, while the other five served as a control. No antibiotics were administered throughout the challenge period. Fecal samples were obtained and ceftiofur-resistant Salmonella and commensal E. coli were isolated. Recovered ceftiofur-resistant isolates had two distinct plasmid profiles, corresponding to non-lactose-fermenting flora (including Salmonella) and E. coli. The E. coli plasmid profile did not share plasmids of the same size with the Salmonella inoculum and all ceftiofur-resistant E. coli isolates were blaCMY-2 negative. The frequency of conjugative transfer of blaCMY-2 from the Salmonella donor to commensal E. coli recipient was <3.0x10-8. A non-CMY-2 mechanism of ceftiofur resistance disseminated throughout the commensal E. coli population, despite the absence of ceftioufur resistant flora in pre-challenge screening. In the absence of antibiotic selective pressure, the in vivo conjugal transfer rate of CMY-2 from Salmonella to E. coli is very low in the pig gastrointestinal tract.Challenge 2: Sixteen three-week-old, weaned pigs were randomly divided into four treatment groups (TG). TGI received an oral inoculation of CMY-2-containing E. coli DH10B and were fed medicated feed. TG2 also received an oral inoculation of CMY-2- containing E. coli DH10B, but were fed non-medicated feed. TG3 were not challenged with CMY-2-containing E. coli DH10B and were fed medicated feed, while TG4 served as a control and did not receive oral inoculation or medicated feed. Each pig was orally inoculated with naladixic-acid resistant Salmonella. Fecal samples were obtained and ceftiofur-resistant E. coli and Salmonella were isolated. Ceftiofur-resistant E. coli shedding was not significantly affected by treatment with medicated feed (Repeated measures ANOVA, p=0.08). The frequency of conjugative transfer of blaCMY-2 from the E. coli DH10B to naladixic-acid resistant Salmonella was… Advisors/Committee Members: LeJeune, Jeffrey (Advisor).

Subjects/Keywords: Animal Diseases

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APA (6^th Edition):

Dodson, K. K. (2005). Transfer Frequency of CMY-2-Encoding Plasmids Among Fecal Flora of Pigs. (Masters Thesis). The Ohio State University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=osu1395851225

Chicago Manual of Style (16^th Edition):

Dodson, Kathryn Kristine. “Transfer Frequency of CMY-2-Encoding Plasmids Among Fecal Flora of Pigs.” 2005. Masters Thesis, The Ohio State University. Accessed March 08, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1395851225.

MLA Handbook (7^th Edition):

Dodson, Kathryn Kristine. “Transfer Frequency of CMY-2-Encoding Plasmids Among Fecal Flora of Pigs.” 2005. Web. 08 Mar 2021.

Vancouver:

Dodson KK. Transfer Frequency of CMY-2-Encoding Plasmids Among Fecal Flora of Pigs. [Internet] [Masters thesis]. The Ohio State University; 2005. [cited 2021 Mar 08]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1395851225.

Council of Science Editors:

Dodson KK. Transfer Frequency of CMY-2-Encoding Plasmids Among Fecal Flora of Pigs. [Masters Thesis]. The Ohio State University; 2005. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=osu1395851225

Michigan State University

14. De Vries, Jennifer L. Mechanism of intestinal and skeletal muscle glucose and amino acid uptake in pituitary pars intermedia dysfunction.

Degree: 2015, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:3585

►

Thesis M.S. Michigan State University. Animal Science 2015.

ABSTRACTMECHANISM OF INTESTINAL AND SKELETAL MUSCLE GLUCOSE AND AMINO ACID UPTAKE IN PITUITARY PARS INTERMEDIA DYSFUNCTIONByJennifer L.… (more)

Subjects/Keywords: Pituitary gland – Diseases; Horses – Diseases; Cushing's syndrome; Animal sciences; Animal diseases; Nutrition

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APA (6^th Edition):

De Vries, J. L. (2015). Mechanism of intestinal and skeletal muscle glucose and amino acid uptake in pituitary pars intermedia dysfunction. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:3585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

De Vries, Jennifer L. “Mechanism of intestinal and skeletal muscle glucose and amino acid uptake in pituitary pars intermedia dysfunction.” 2015. Thesis, Michigan State University. Accessed March 08, 2021. http://etd.lib.msu.edu/islandora/object/etd:3585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

De Vries, Jennifer L. “Mechanism of intestinal and skeletal muscle glucose and amino acid uptake in pituitary pars intermedia dysfunction.” 2015. Web. 08 Mar 2021.

Vancouver:

De Vries JL. Mechanism of intestinal and skeletal muscle glucose and amino acid uptake in pituitary pars intermedia dysfunction. [Internet] [Thesis]. Michigan State University; 2015. [cited 2021 Mar 08]. Available from: http://etd.lib.msu.edu/islandora/object/etd:3585.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

De Vries JL. Mechanism of intestinal and skeletal muscle glucose and amino acid uptake in pituitary pars intermedia dysfunction. [Thesis]. Michigan State University; 2015. Available from: http://etd.lib.msu.edu/islandora/object/etd:3585

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Raletobana, Juliah Gabasenye. Sero-prevalence and risk factors of foot and mouth disease in Goats in Ngamiland and North East Districts of Botswana.

Degree: 2014, University of Zimbabwe

URL: http://dspace.unza.zm/handle/123456789/3194

► Foot and mouth disease (FMD) is an economically and highly contagious viral disease that affects cloven-hoofed domestic and wild animals. Although adult animals generally recover,… (more)

Subjects/Keywords: Communicable Diseases in Animals; Animal Diseases; Communicable Diseases-Veterinary

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APA (6^th Edition):

Raletobana, J. G. (2014). Sero-prevalence and risk factors of foot and mouth disease in Goats in Ngamiland and North East Districts of Botswana. (Thesis). University of Zimbabwe. Retrieved from http://dspace.unza.zm/handle/123456789/3194

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Raletobana, Juliah Gabasenye. “Sero-prevalence and risk factors of foot and mouth disease in Goats in Ngamiland and North East Districts of Botswana.” 2014. Thesis, University of Zimbabwe. Accessed March 08, 2021. http://dspace.unza.zm/handle/123456789/3194.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Raletobana, Juliah Gabasenye. “Sero-prevalence and risk factors of foot and mouth disease in Goats in Ngamiland and North East Districts of Botswana.” 2014. Web. 08 Mar 2021.

Vancouver:

Raletobana JG. Sero-prevalence and risk factors of foot and mouth disease in Goats in Ngamiland and North East Districts of Botswana. [Internet] [Thesis]. University of Zimbabwe; 2014. [cited 2021 Mar 08]. Available from: http://dspace.unza.zm/handle/123456789/3194.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Raletobana JG. Sero-prevalence and risk factors of foot and mouth disease in Goats in Ngamiland and North East Districts of Botswana. [Thesis]. University of Zimbabwe; 2014. Available from: http://dspace.unza.zm/handle/123456789/3194

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Danielle Gava. Padronização de técnicas de diagnóstico para Circovirus Suíno Tipo 2 e estudo do papel do macho na epidemiologia da doença.

Degree: 2006, Universidade do Estado de Santa Catarina

URL: http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=438

► A Síndrome Multissistêmica do Definhamento do Suíno (SMDS) é uma doença multifatorial, causada pelo Circovirus Suíno Tipo 2 (PCV-2). Clinicamente está caracterizada por definhamento, aumento… (more)

▼ A Síndrome Multissistêmica do Definhamento do Suíno (SMDS) é uma doença multifatorial, causada pelo Circovirus Suíno Tipo 2 (PCV-2). Clinicamente está caracterizada por definhamento, aumento de tamanho dos linfonodos, palidez e/ou icterícia e sinais digestivos e respiratórios. As lesões afetam principalmente tecidos linfóides, pulmão, rim e fígado. Os achados microscópicos consistem principalmente em infiltração linfo-histiocitária em vários órgãos e depleção dos folículos linfóides. Entretanto, para estabelecer o diagnóstico conclusivo da SMDS, é necessário associar sinais clínicos, lesões macroscópicas e microscópicas, além da demonstração do antígeno ou DNA viral. Assim, o objetivo deste trabalho foi padronizar duas técnicas de diagnóstico: imunocitoquímica (ICQ) em duas linhagens celulares (ST e VERO), utilizando dois tipos de anticorpos primários anti PCV-2 (policlonal produzido em coelho e policlonal produzido em suíno) para determinação de anticorpos anti PCV-2 em soro suíno e, imunohistoquímica (IHQ) em diversos tecidos parafinizados de suínos (linfonodo, pulmão, fígado, timo, rim e intestino), utilizando dois tipos de anticorpos primários (monoclonal produzido em camundongo e policlonal produzido em coelho) para demonstração do antígeno viral. Na ICQ, ambos cultivos celulares foram suscetíveis à infecção, podendo-se detectar o antígeno tanto no núcleo quanto no citoplasma das células, com os dois anticorpos primários. A IHQ foi padronizada nos diversos tecidos com os dois anticorpos, sendo que o antígeno foi verificado principalmente em macrófagos, histiócitos e outras células inflamatórias. Com o objetivo de verificar a transmissão via sêmen de PCV-2 e sua capacidade infecciosa para a fêmea e para a progênie, 20 fêmeas negativas para PCV-2 foram inseminadas, 10 com sêmen de macho negativo e 10 com sêmen de macho positivo. Após a inseminação, as 20 fêmeas foram acompanhadas clinicamente e foi coletado sangue para pesquisa de DNA de PCV-2 por nested-PCR. Baseado no resultado, 4 fêmeas das 20 foram selecionadas (1 fêmea soronegativa inseminada com sêmen negativo, 2 fêmeas soronegativas inseminadas com sêmen positivo e 1 fêmea soronegativa inseminada com sêmen positivo, mas que soroconverteu ao redor dos 30 dias de gestação). Após o parto, 12 leitões machos, 3 de cada fêmea, foram selecionados e mantidos em isolamento. Amostras de sêmen e soro foram coletadas para pesquisa de DNA de PCV-2 por nested-PCR. Para verificar quais órgãos abrigam o PCV-2, os leitões sofreram eutanásia ao redor dos nove meses de idade, e amostras de órgãos linfóides, sistêmicos e reprodutivos foram coletadas para avaliação por nested-PCR, histopatologia (HE) e IHQ. Ao avaliar o soro por ICQ, todos os 12 leitões soroconverteram (4 foram fortemente positivos, 3 moderadamente positivos e 5 fracamente positivos). Ao avaliar as amostras por nested-PCR, vários tecidos foram positivos em 10 dos 12 suínos. Ao avaliar as mesmas amostras por IHQ, várias foram positivas em 8 dos 12 suínos. No geral, os resultados obtidos nas diferentes amostras… Advisors/Committee Members: Janice Reis Ciacci Zanella.

Subjects/Keywords: PATOLOGIA ANIMAL; Swine - Diseases; Suíno - Doenças

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gava, D. (2006). Padronização de técnicas de diagnóstico para Circovirus Suíno Tipo 2 e estudo do papel do macho na epidemiologia da doença. (Thesis). Universidade do Estado de Santa Catarina. Retrieved from http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gava, Danielle. “Padronização de técnicas de diagnóstico para Circovirus Suíno Tipo 2 e estudo do papel do macho na epidemiologia da doença.” 2006. Thesis, Universidade do Estado de Santa Catarina. Accessed March 08, 2021. http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gava, Danielle. “Padronização de técnicas de diagnóstico para Circovirus Suíno Tipo 2 e estudo do papel do macho na epidemiologia da doença.” 2006. Web. 08 Mar 2021.

Vancouver:

Gava D. Padronização de técnicas de diagnóstico para Circovirus Suíno Tipo 2 e estudo do papel do macho na epidemiologia da doença. [Internet] [Thesis]. Universidade do Estado de Santa Catarina; 2006. [cited 2021 Mar 08]. Available from: http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gava D. Padronização de técnicas de diagnóstico para Circovirus Suíno Tipo 2 e estudo do papel do macho na epidemiologia da doença. [Thesis]. Universidade do Estado de Santa Catarina; 2006. Available from: http://www.tede.udesc.br/tde_busca/arquivo.php?codArquivo=438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Stellenbosch University

17. Otto, Delita. Exploring underlying mechanisms driving the onset of stress-induced insulin resistance.

Degree: MSc, Physiological Sciences, 2012, Stellenbosch University

URL: http://hdl.handle.net/10019.1/20125

►

ENGLISH ABSTRACT: Physical and psychological stressors trigger activation of the hypothalamo-pituitary-adrenocortical (HPA) axis that leads to enhanced secretion of glucocorticoids e.g. cortisol. Moreover, chronic activation… (more)

▼

ENGLISH ABSTRACT: Physical and psychological stressors trigger activation of the hypothalamo-pituitary-adrenocortical (HPA) axis that leads to enhanced secretion of glucocorticoids e.g. cortisol. Moreover, chronic activation of this pathway may elevate oxidative stress that is linked to the onset of insulin resistance and cardiovascular diseases (CVD). Our laboratory previously found that oxidative stress increases flux through metabolic circuits such as the hexosamine biosynthetic pathway (HBP), in effect increasing its modification of target proteins post-transcriptionally with O-GlcNAc moeities. This in turn may alter protein function and contribute to the onset of myocardial insulin resistance and impaired contractile function. Since the underlying mechanisms linking chronic stress to cardiometabolic pathophysiology are poorly understood, we hypothesised that cortisol elicits myocardial oxidative stress, HBP activation, and decreased glucose uptake (due to attenuated glucose transport functionality) with detrimental outcomes, i.e. insulin resistance and apoptosis. To investigate this hypothesis we established an in vitro model using HL-1 cardiomyocytes, with which we evaluated the degree of O-GlcNAcylation and oxidative stress in response to a range of time-dose treatments with dexamethasone (synthetic glucocorticoid). Glucose transporter 4 (GLUT4) translocation to the sarcolemma was also assessed. In agreement with the literature, results suggest that GLUT4 translocation is significantly decreased subsequent to dexamethasone treatment. Although no significant differences were observed with regards to oxidative stress or O-GlcNAcylation, the data show that dexamethasone increased the latter with a maximal effect after two hours exposure to the 10-6 M dose. Although our results were not conclusive, the data suggest a potential novel link between dexamethasone exposure, HBP activation and decreased GLUT4 translocation. Based on our findings we propose that detrimental effects of chronic stress on the heart may be mediated by increased HBP flux. Given that glucocorticoid excess and GLUT4 dysregulation have been associated with insulin resistance (and related metabolic derangements and diseases), these results provide new targets for potential therapeutic agents.

AFRIKAANSE OPSOMMING: Fisiese sowel as psigologiese stressors veroorsaak die aktivering van die hipotalamiese-hipo seale-bynier (HHB) pad wat lei tot die verhoogde sekresie van glukokortikoïede soos kortisol. Kroniese aktivering van hierdie pad kan ook oksidatiewe stres verhoog wat weer tot insulienweerstandigheid en kardiovaskulêre siektes (KVS) kan lei. Navorsing uit ons laboratorium het voorheen bewys dat oksidatiewe stres 'n toename in vloei deur metaboliese paaie soos die heksoamine biosintetiese pad (HBP) kan veroorsaak deur die modi sering van teikenproteïene met O-GlcNAc motiewe. Dit kan weer proteïen funksie verander en bydra tot die ontstaan van miokardiale insulienweerstandigheid en verswakte kontraktiele funksie.…

Advisors/Committee Members: Essop, M. F., Stellenbosch University. Faculty of Science. Dept. of Physiological Sciences..

Subjects/Keywords: Physiology (Human and animal); Cardiovascular diseases; Apoptosis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Otto, D. (2012). Exploring underlying mechanisms driving the onset of stress-induced insulin resistance. (Masters Thesis). Stellenbosch University. Retrieved from http://hdl.handle.net/10019.1/20125

Chicago Manual of Style (16^th Edition):

Otto, Delita. “Exploring underlying mechanisms driving the onset of stress-induced insulin resistance.” 2012. Masters Thesis, Stellenbosch University. Accessed March 08, 2021. http://hdl.handle.net/10019.1/20125.

MLA Handbook (7^th Edition):

Otto, Delita. “Exploring underlying mechanisms driving the onset of stress-induced insulin resistance.” 2012. Web. 08 Mar 2021.

Vancouver:

Otto D. Exploring underlying mechanisms driving the onset of stress-induced insulin resistance. [Internet] [Masters thesis]. Stellenbosch University; 2012. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10019.1/20125.

Council of Science Editors:

Otto D. Exploring underlying mechanisms driving the onset of stress-induced insulin resistance. [Masters Thesis]. Stellenbosch University; 2012. Available from: http://hdl.handle.net/10019.1/20125

Addis Ababa University

18. GEZAHEGN ALEMAYEHU, ALEMAYEHU. RISK ASSESSMENTS OF PRIORITIZED TRANSBOUNDARY DISEASES IN BORENA BULLS MARKET CHAIN AND ITS IMPLICATION FOR INTERNATIONAL TRADE .

Degree: 2014, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/5680

► Risks of introduction of transboundary animal diseases (TADs) such as foot and mouth disease (FMD), lumpy skin disease (LSD) and contagious bovine pleuropnumonia (CBPP) through… (more)

▼ Risks of introduction of transboundary animal diseases (TADs) such as foot and mouth disease (FMD), lumpy skin disease (LSD) and contagious bovine pleuropnumonia (CBPP) through traded Borena bulls to market chain and its consequences were assessed. The assessment used the framework that has been recommended by the World Animal Health Organization (OIE) for risk analysis. Likelihoods for release and exposure were estimated by a qualitative scale ranging from negligible to very high. Whereas, the consequences resulted from diseases occurrences were assessed quantitatively. Fattened bulls intended to export originated mainly from Borena pastoral system where these transboundary animal diseases were endemically established. The likelihood of the introduction of TADs to the market chain through traded Borena bulls is found to be high for FMD and LSD and medium for CBPP. The probability of bulls in the feedlots becoming exposed to FMD virus and Mycoplasma mycoides subsp. mycoides small-colony type (MmmSC) bacteria is also high and very high for LSD virus. Biological consequence such as prevalence and incidence and economic loss were assessed. From the total of 11189 bulls observed during outbreak investigation of LSD in six sites of feedlot operation in and around Adama, 681(6.1%) and 204(1.8%) bulls were found affected and dead with LSD, respectively. From the total of 38187 bulls examined for FMD and CBPP antibodies, 5536(14.5%) and 150(0.4%) were found positive and subsequently rejected from international market in 2011, respectively. The total annual (2011) economic loss due to prioritized TADs was estimated to be 4,081,972.2 USD which is equivalent to 69,230,245.12 ETB (1USD= 16.96 ETB). The analysis of matrix scoring showed strong agreement (W=0.837 to 0.989; P=0.000) among the 10 informant groups for the disease indicators. The introduction of those diseases to the market chain of Borena bull for export is discussed in terms of international markets and trade disruptions. The risk estimates for all prioritized transboundary diseases are greater than negligible, therefore, transboundary diseases prevention strategy along the chain should be carefully considered by the Ethiopian veterinary services. Advisors/Committee Members: Dr. Girma Zewde (advisor).

Subjects/Keywords: Borena Bulls; Market Chain; Transboundary Animal Diseases

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APA (6^th Edition):

GEZAHEGN ALEMAYEHU, A. (2014). RISK ASSESSMENTS OF PRIORITIZED TRANSBOUNDARY DISEASES IN BORENA BULLS MARKET CHAIN AND ITS IMPLICATION FOR INTERNATIONAL TRADE . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/5680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

GEZAHEGN ALEMAYEHU, ALEMAYEHU. “RISK ASSESSMENTS OF PRIORITIZED TRANSBOUNDARY DISEASES IN BORENA BULLS MARKET CHAIN AND ITS IMPLICATION FOR INTERNATIONAL TRADE .” 2014. Thesis, Addis Ababa University. Accessed March 08, 2021. http://etd.aau.edu.et/dspace/handle/123456789/5680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

GEZAHEGN ALEMAYEHU, ALEMAYEHU. “RISK ASSESSMENTS OF PRIORITIZED TRANSBOUNDARY DISEASES IN BORENA BULLS MARKET CHAIN AND ITS IMPLICATION FOR INTERNATIONAL TRADE .” 2014. Web. 08 Mar 2021.

Vancouver:

GEZAHEGN ALEMAYEHU A. RISK ASSESSMENTS OF PRIORITIZED TRANSBOUNDARY DISEASES IN BORENA BULLS MARKET CHAIN AND ITS IMPLICATION FOR INTERNATIONAL TRADE . [Internet] [Thesis]. Addis Ababa University; 2014. [cited 2021 Mar 08]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5680.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

GEZAHEGN ALEMAYEHU A. RISK ASSESSMENTS OF PRIORITIZED TRANSBOUNDARY DISEASES IN BORENA BULLS MARKET CHAIN AND ITS IMPLICATION FOR INTERNATIONAL TRADE . [Thesis]. Addis Ababa University; 2014. Available from: http://etd.aau.edu.et/dspace/handle/123456789/5680

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Nelson Mandela Metropolitan University

19. [No author]. Characterization of a glycated gelatin model to explore the therapeutic properties of macrofungi in diabetic wound healing: an in vitro study.

Degree: Faculty of Science, 2017, Nelson Mandela Metropolitan University

URL: http://hdl.handle.net/10948/11992

► Diabetic wounds frequently undergo impaired and prolonged wound healing due to a multitude of factors including hypoxia, impaired angiogenesis, hyperglycaemia, formation of ROS and AGEs,… (more)

▼ Diabetic wounds frequently undergo impaired and prolonged wound healing due to a multitude of factors including hypoxia, impaired angiogenesis, hyperglycaemia, formation of ROS and AGEs, and infection - all of which may lead to cellular dysfunction. To date, however, treatment options for individuals suffering from impaired diabetic wound healing are limited, non-specific, and generally unsuccessful. The search for new and effective treatment strategies is severely hampered by the availability of adequately characterized screening models which comprehensively mimic the complexity of the diabetic wound healing process. In order to explore natural products as potential therapeutics to treat diabetic wounds and to encourage more research on this topic, this study sought out to develop and characterize a more convenient and cost effective in vitro screening assay which mimics the effects of protein glycation on the healing process of diabetic wounds. As proof of principal, this model was subsequently used to screen the potential of five wild mushroom species (P. tinctorius, R. capensis, B. badius, P. ostreatus and G. lucidum) as suitable diabetic wound healing therapies. The glycated gelatin model developed during this study was found to suitably mimic the diabetic state as it successfully simulated the major cellular dysfunctions in macrophages (NO production, phagocytosis, macrophage polarization, NF-ĸB translocation and COX-2 expression) and fibroblasts (proliferation and migration) documented during diabetic wound healing. Together these findings provide confidence that the model may serve as a valuable tool to study the poorly understood mechanisms which characterize cellular dysfunction in response to AGE accumulation and also to aid the identification of novel therapeutic agents to treat this pathology. Screening a number of mushroom extracts revealed that the ethanol extracts of R. capensis and P. ostreatus had the greatest potential for attenuating chronic inflammation due to their ability to promote macrophage phagocytosis, increased M2 activation (R. capensis) and decreased M1 activation (P. ostreatus) as well as reduced COX-2 expression while the water extract of G. lucidum proved to be the most promising candidate for stimulating fibroplasia as it was the most successful at promoting both fibroblast proliferation and migration. Different mushroom species were thus shown to promote different stages of the wound healing process providing sufficient evidence to support further studies related to the use of macrofungi as therapeutic agents in the search for more cost-effective and efficient treatment strategies for impaired diabetic wound healing.

Subjects/Keywords: Diabetes – Animal models; Chronic diseases – Age factors

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APA (6^th Edition):

author], [. (2017). Characterization of a glycated gelatin model to explore the therapeutic properties of macrofungi in diabetic wound healing: an in vitro study. (Thesis). Nelson Mandela Metropolitan University. Retrieved from http://hdl.handle.net/10948/11992

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

author], [No. “Characterization of a glycated gelatin model to explore the therapeutic properties of macrofungi in diabetic wound healing: an in vitro study.” 2017. Thesis, Nelson Mandela Metropolitan University. Accessed March 08, 2021. http://hdl.handle.net/10948/11992.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

author], [No. “Characterization of a glycated gelatin model to explore the therapeutic properties of macrofungi in diabetic wound healing: an in vitro study.” 2017. Web. 08 Mar 2021.

Vancouver:

author] [. Characterization of a glycated gelatin model to explore the therapeutic properties of macrofungi in diabetic wound healing: an in vitro study. [Internet] [Thesis]. Nelson Mandela Metropolitan University; 2017. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10948/11992.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

author] [. Characterization of a glycated gelatin model to explore the therapeutic properties of macrofungi in diabetic wound healing: an in vitro study. [Thesis]. Nelson Mandela Metropolitan University; 2017. Available from: http://hdl.handle.net/10948/11992

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

College of William and Mary

20. Scanlon, Christine H. The Potential for Transmission of Perkinsus Marinus by Fecal Matter from the Eastern Oyster, Crassostrea virginica.

Degree: MS, Virginia Institute of Marine Science, 1997, College of William and Mary

URL: https://scholarworks.wm.edu/etd/1539617725

Subjects/Keywords: Animal Diseases; Zoology

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APA (6^th Edition):

Scanlon, C. H. (1997). The Potential for Transmission of Perkinsus Marinus by Fecal Matter from the Eastern Oyster, Crassostrea virginica. (Masters Thesis). College of William and Mary. Retrieved from https://scholarworks.wm.edu/etd/1539617725

Chicago Manual of Style (16^th Edition):

Scanlon, Christine H. “The Potential for Transmission of Perkinsus Marinus by Fecal Matter from the Eastern Oyster, Crassostrea virginica.” 1997. Masters Thesis, College of William and Mary. Accessed March 08, 2021. https://scholarworks.wm.edu/etd/1539617725.

MLA Handbook (7^th Edition):

Scanlon, Christine H. “The Potential for Transmission of Perkinsus Marinus by Fecal Matter from the Eastern Oyster, Crassostrea virginica.” 1997. Web. 08 Mar 2021.

Vancouver:

Scanlon CH. The Potential for Transmission of Perkinsus Marinus by Fecal Matter from the Eastern Oyster, Crassostrea virginica. [Internet] [Masters thesis]. College of William and Mary; 1997. [cited 2021 Mar 08]. Available from: https://scholarworks.wm.edu/etd/1539617725.

Council of Science Editors:

Scanlon CH. The Potential for Transmission of Perkinsus Marinus by Fecal Matter from the Eastern Oyster, Crassostrea virginica. [Masters Thesis]. College of William and Mary; 1997. Available from: https://scholarworks.wm.edu/etd/1539617725

University of Helsinki

21. Nikkilä, Anni. Koirien brakykefaalinen hengitystieoireyhtymä.

Degree: Department of Equine and Small Animal Medicine; Helsingin yliopisto, Eläinlääketieteellinen tiedekunta, Kliinisen hevos- ja pieneläinlääketieteen osasto; Helsingfors universitet, Veterinärmedicinska fakulteten, Avdelningen för klinisk häst- och smådjursmedicin, 2017, University of Helsinki

URL: http://hdl.handle.net/10138/230217

► Työn tavoitteena oli luoda ajantasainen katsaus siihen, miten brakykefaalinen hengitystieoireyhtymä vaikuttaa koiran elämään sekä keinoihin, joilla hengitystieoireyhtymän esiintymistä voitaisiin vähentää. Brakykefaalisten eli lyhytkuonoisten ja -kalloisten… (more)

▼ Työn tavoitteena oli luoda ajantasainen katsaus siihen, miten brakykefaalinen hengitystieoireyhtymä vaikuttaa koiran elämään sekä keinoihin, joilla hengitystieoireyhtymän esiintymistä voitaisiin vähentää. Brakykefaalisten eli lyhytkuonoisten ja -kalloisten koirarotujen suosio on lisääntynyt viimevuosina maailmanlaajuisesti. Monet brakykefaaliset koirarodut kuitenkin kärsivät ylähengitystieoireyhtymästä, joka on seurausta kallon luiden ja nielun sekä nenäontelon alueen pehmytkudosten mittasuhteiden epätasapainosta. Brakykefaalisten koirien lyhytkuonoinen ulkonäkö on aiheutettu ihmisten toimesta jalostuksella. Koiran pään pehmytkudokset eivät ole lyhentyneet luuston kanssa samassa suhteessa, joten suhteessa liian suuret pehmytkudosrakenteet voivat tukkia ylähengitysteitä ja vaikeuttaa koiran hengittämistä. Tyypillisimpiä oireyhtymään liittyviä anatomisia muutoksia ovat ahtautuneet sieraimet ja nenän eteinen, epäjärjestäytyneet nenäkuorikot, pidentynyt pehmeä kitalaki, ympäri kääntyneet kurkunpään umpipussit sekä kaventunut henkitorvi. Oireyhtymälle tunnusomaisia hengitystieoireita ovat epänormaalit hengitysäänet, kuten kuorsaus ja rohina, hengitysvaikeudet, alentunut rasituksen sietokyky ja alentunut lämmönsäätelykyky. Suurimmalla osalla oireyhtymästä kärsivistä koirista on hengitystieoireiden lisäksi myös ruoansulatuskanavan anatomisia tai toiminnallisia muutoksia. Brakykefaalisten rotujen suosion kasvaessa myös huoli niiden terveysongelmista on noussut esille. Oireyhtymän esiintyvyys brakykefaalisilla koiraroduilla on korkea ja sillä on suuri negatiivinen vaikutus koirien hyvinvointiin. Koska oireyhtymä on seurausta ihmisten tekemistä jalostusvalinnoista, on tärkeää, että tulevaisuuden jalostusvalinnoissa koirien terveys pidetään etusijalla ja äärimmäisiä rakenteita vältetään. Rotumääritelmät ohjaavat jalostusvalintoja, joten niiden uudelleen muotoilu on tärkeää. Koiran riski sairastua hengitystieoireyhtymään kasvaa kuonon lyhentyessä, joten pidemmän kuonon jalostaminen pienentäisi koirien riskiä sairastua. Oireyhtymän esiintymisen vähentämiseksi on ehdotettu esimerkiksi geenitestin kehittämistä, roturisteytysten käyttöä sekä vain matalan riskin rakenteisten koirien käyttöä jalostuksessa. Yksi tärkeimmistä keinoista vähentää oireyhtymän esiintymistä on välttää hengitystieoireyhtymää sairastavien koirien käyttöä jalostuksessa. Oireyhtymän vakavuutta arvioivien menetelmien avulla jalostukseen voidaan valita vain terveimmät yksilöt riskirotujen sisältä. Näitä menetelmiä ovat esimerkiksi omistajan kertomiin oireisiin perustuva kyselykaavake, eläinlääkärin tekemä kliininen arviointi, sierainten ahtauden mittaaminen, kuonon suhteellisen pituuden vertaaminen kallon pituuteen, kävelytesti sekä keuhkojen toimintakoe. Yrityksiä vähentää oireyhtymän esiintyvyyttä hankaloittaa muun muassa se, ettei useissa brakykefaalisissa roduissa ole jäljellä riittävästi yksilöitä, joiden rakenne ei aiheuttaisi suurta riskiä sairastua oireyhtymään. Lisäksi on todettu, että koirien omistajat voivat pitää hengitystieoireita brakykefaalisille…

Subjects/Keywords: Pieneläinten sairaudet; Smådjurssjukdomar; Small Animal Diseases

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APA (6^th Edition):

Nikkilä, A. (2017). Koirien brakykefaalinen hengitystieoireyhtymä. (Thesis). University of Helsinki. Retrieved from http://hdl.handle.net/10138/230217

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Nikkilä, Anni. “Koirien brakykefaalinen hengitystieoireyhtymä.” 2017. Thesis, University of Helsinki. Accessed March 08, 2021. http://hdl.handle.net/10138/230217.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Nikkilä, Anni. “Koirien brakykefaalinen hengitystieoireyhtymä.” 2017. Web. 08 Mar 2021.

Vancouver:

Nikkilä A. Koirien brakykefaalinen hengitystieoireyhtymä. [Internet] [Thesis]. University of Helsinki; 2017. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10138/230217.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Nikkilä A. Koirien brakykefaalinen hengitystieoireyhtymä. [Thesis]. University of Helsinki; 2017. Available from: http://hdl.handle.net/10138/230217

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

AUT University

22. Al-Rawi, Mohammad. Computational fluid dynamic modelling for arterial diseases assessment .

Degree: 2013, AUT University

URL: http://hdl.handle.net/10292/5202

► One of the leading causes of death is cardiovascular disease, being 30% of all deaths worldwide and 40% of those in New Zealand. In other… (more)

▼ One of the leading causes of death is cardiovascular disease, being 30% of all deaths worldwide and 40% of those in New Zealand. In other words, every 90 minutes a New Zealander dies due to cardiovascular disease. Cardiovascular mortality is higher in New Zealand than Australia, but the reasons for this are not clear. Although Australia and New Zealand are similar politically, culturally, and socioeconomically, mortality from cardiovascular disease is about 25% higher in New Zealand than in Australia. In recent years, engineers and scientists have collaborated with the medical community to find new methods and approaches for assessing and investigating the development of cardiovascular diseases such as abdominal aortic aneurysm and atherosclerosis. In this thesis, atherosclerosis and aneurysm diseases are investigated and analysed using computational fluid dynamic/finite element (CFD/FE) methods. These models are validated against the in vivo and in vitro experiments performed on animals. The experimental models are also investigated; the assessment of arterial blockages using blood pressure waveforms obtained invasively at the right femoral artery. The animal experiments are performed following appropriate ethical protocols (R915) on Wistar rats weighing between 250-350g. An arterial blockage is created surgically within the abdominal aorta of healthy animals to create an unhealthy condition. Blood pressure waveforms are measured by injecting catheter into the right femoral artery of the rat. These measurements are taken at the baseline (healthy condition) and at four different severities of arterial blockage of the abdominal aorta for the same specimen. In vivo and in vitro measurements of the arterial diameter and wall thickness are also taken using Magnetic Resonance Imaging (MRI) and microscopic techniques, respectively. These data are then input onto CFD/FE models in order to develop a new, non-invasive method of assessing arterial blockage. The experimental and computational results indicate that arterial blockages occurring within the abdominal aorta could be assessed, and the development of the disease diagnosed, very clearly and non-invasively at the right femoral artery. The findings of the animal model are then implemented in the human model for screening atherosclerosis and aneurysm at the brachial artery. These diseases are modelled and simulated in a 3D CFD/FE aorta geometry using the fluid–structure interaction (FSI) approach on the commercial software ANSYS®14.0. Literature blood flow waveform datum is assumed at the inlet and invasive catheter pulsatile pressure waveforms data is imposed at the four outlets of the aorta (provided by Green Lane Hospital under ethic approval number NTX/09/11/109). Correlations between the stress phase angle (SPA), augmentation index (AI), lumen diameter and blood pressure waveforms for various scenarios of diseased models are made and compared to the control model. The results show that CFD/FE models with different radii and thicknesses at the abdominal… Advisors/Committee Members: Al-Jumaily, Ahmed (advisor), Lowe, Andrew (advisor).

Subjects/Keywords: CFD/FE; Animal model; Arterial diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Al-Rawi, M. (2013). Computational fluid dynamic modelling for arterial diseases assessment . (Thesis). AUT University. Retrieved from http://hdl.handle.net/10292/5202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Al-Rawi, Mohammad. “Computational fluid dynamic modelling for arterial diseases assessment .” 2013. Thesis, AUT University. Accessed March 08, 2021. http://hdl.handle.net/10292/5202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Al-Rawi, Mohammad. “Computational fluid dynamic modelling for arterial diseases assessment .” 2013. Web. 08 Mar 2021.

Vancouver:

Al-Rawi M. Computational fluid dynamic modelling for arterial diseases assessment . [Internet] [Thesis]. AUT University; 2013. [cited 2021 Mar 08]. Available from: http://hdl.handle.net/10292/5202.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Al-Rawi M. Computational fluid dynamic modelling for arterial diseases assessment . [Thesis]. AUT University; 2013. Available from: http://hdl.handle.net/10292/5202

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Arkansas

23. Rathinam, Thilakar. Development of a Turkey Coccidiosis Vaccine Candidate: an Attenuated Line of the Protozoan Parasite, Eimeria meleagrimitis.

Degree: PhD, 2014, University of Arkansas

URL: https://scholarworks.uark.edu/etd/2112

► Coccidiosis is an economically important enteric disease of poultry caused by protozoan parasites belonging to the genus Eimeria. Drugs are most commonly used to… (more)

▼ Coccidiosis is an economically important enteric disease of poultry caused by protozoan parasites belonging to the genus Eimeria. Drugs are most commonly used to control coccidiosis. Widespread usage of anticoccidial drugs in the field has resulted in development of drug resistant strains and consequently decreased drug efficacy. An alternative control strategy using attenuated vaccines is desired. A series of experiments was designed to identify, isolate and attenuate a strain of a common and pathogenic species of Eimeria of turkeys, E. meleagrimitis. Sensitivity of field isolates of turkey coccidia to the anticoccidials drugs amprolium, clopidol, diclazuril, and monensin was investigated. A total of thirty-four isolates comprising mixed species from farms across the country were tested. Of these, four isolates were sensitive to monensin, twelve sensitive to diclazuril, and seventeen sensitive to clopidol and none to amprolium. One isolate, designated MN2, was sensitive to three drugs tested and was selected for further investigation. The different Eimeria species present in the isolates were identified using polymerase chain reaction amplification of cox-1 gene and E. meleagrimitis was the most common species seen. A pure clone of E. meleagrimitis was developed and the pathogenicity and fecundity of the isolated E. meleagrimitis strain was tested and compared to a standard reference E. meleagrimitis strain. Data from the parameters tested showed that the strain had the same characteristics as that of the reference strain. An attenuated line of E. meleagrimitis was developed by repeated propagation of the parasite in turkeys and collection of the very first oocysts produced following infection. After twenty generations of selection, a line with abbreviated life cycle of -16h was developed. Pathogenicity and immunogenicity of this line was tested and compared with the parent strain. The attenuated line was proven to be non-pathogenic but was immunogenic. The developed line is a candidate for attenuated vaccine against turkey coccidiosis. Advisors/Committee Members: H. David Chapman, Michael F. Slavik, Thomas A. Yazwinski.

Subjects/Keywords: Attenuation; Coccidiosis; Eimeria; Turkey; Animal Diseases; Parasitology

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APA (6^th Edition):

Rathinam, T. (2014). Development of a Turkey Coccidiosis Vaccine Candidate: an Attenuated Line of the Protozoan Parasite, Eimeria meleagrimitis. (Doctoral Dissertation). University of Arkansas. Retrieved from https://scholarworks.uark.edu/etd/2112

Chicago Manual of Style (16^th Edition):

Rathinam, Thilakar. “Development of a Turkey Coccidiosis Vaccine Candidate: an Attenuated Line of the Protozoan Parasite, Eimeria meleagrimitis.” 2014. Doctoral Dissertation, University of Arkansas. Accessed March 08, 2021. https://scholarworks.uark.edu/etd/2112.

MLA Handbook (7^th Edition):

Rathinam, Thilakar. “Development of a Turkey Coccidiosis Vaccine Candidate: an Attenuated Line of the Protozoan Parasite, Eimeria meleagrimitis.” 2014. Web. 08 Mar 2021.

Vancouver:

Rathinam T. Development of a Turkey Coccidiosis Vaccine Candidate: an Attenuated Line of the Protozoan Parasite, Eimeria meleagrimitis. [Internet] [Doctoral dissertation]. University of Arkansas; 2014. [cited 2021 Mar 08]. Available from: https://scholarworks.uark.edu/etd/2112.

Council of Science Editors:

Rathinam T. Development of a Turkey Coccidiosis Vaccine Candidate: an Attenuated Line of the Protozoan Parasite, Eimeria meleagrimitis. [Doctoral Dissertation]. University of Arkansas; 2014. Available from: https://scholarworks.uark.edu/etd/2112

Utah State University

24. Peterson, Christopher. Evaluation of Therapeutics for an Enterovirus 71 Infection in an AG129 Mouse Model.

Degree: MS, Animal, Dairy, and Veterinary Sciences, 2018, Utah State University

URL: https://digitalcommons.usu.edu/etd/7278

► Discovered in 1969 in California, enterovirus 71 (EV-71) is a serious cause of disease in young children. It is one of the major causative… (more)

▼ Discovered in 1969 in California, enterovirus 71 (EV-71) is a serious cause of disease in young children. It is one of the major causative agents of hand, food, and mouth disease (HFMD), and can produce neurological complications, such as meningitis, encephalitis, and an acute flaccid paralysis. For serious cases, the fatality rate can be up to 26%, almost exclusively in young children. While the virus was initially discovered in the United States, it was soon detected in the Eastern hemisphere, causing outbreaks in Europe and Asia. The largest outbreak occurred in Taiwan in 2008, with approximately 490,000 cases and 128 fatalities. However, despite the seriousness of EV-71, there are currently no approved antiviral treatments. Physicians rely on supportive care and the off-label use of a purified antibody mixture, intravenous immunoglobulin, for treatment. Part of the difficulty in developing antivirals for EV-71 is a lack of drug testing in animal models. Animal testing is a crucial step in drug development, determining which compounds will progress to clinical trials in humans. However, viruses that cause disease in humans do not necessarily cause disease or the same type of disease in animals. As such, viruses often need to be adapted before they can cause disease in their animal hosts. Adaption isn’t always successful and can result in a virus that produces disease that is unlike that seen in humans. Furthermore, some animal models can produce disease only under a strict set of conditions, such as newborn mice. Sometimes these animal model conditions may be impractical for testing potential treatments. At the Institute for Antiviral Research (IAR), we developed an animal model for EV-71 in four-week-old AG129 mice. AG129 mice lack the alpha, beta, and gamma interferon receptors, making them immunocompromised. Being immunocompromised, these mice are more susceptible to infection, including infection from human viruses. In our model, EV-71 infection produces neurological signs, including a rear-limb paralysis (similar to the paralysis seen children with EV-71). The virus is also lethal in these animals, which provides an observable and consistent baseline for evaluating potential drugs. We assessed twenty-four potential treatments in our EV-71 model. Two compounds, STF434 and STF1019, provided 30% and 87% protection against mortality. Intravenous immunoglobulin was also examined and found to be about 50% protective against mortality, depending on the dose and time of administration. Intravenous immunoglobulin also reduced inflammatory modulators (cytokines) in the brain and spinal cord. We consider this to be highly relevant, given that inflammation is a serious component of EV-71 infection. Advisors/Committee Members: E. Bart Tarbet, ;.

Subjects/Keywords: Enterovirus; Antiviral; Virology; Animal Sciences; Virus Diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Peterson, C. (2018). Evaluation of Therapeutics for an Enterovirus 71 Infection in an AG129 Mouse Model. (Masters Thesis). Utah State University. Retrieved from https://digitalcommons.usu.edu/etd/7278

Chicago Manual of Style (16^th Edition):

Peterson, Christopher. “Evaluation of Therapeutics for an Enterovirus 71 Infection in an AG129 Mouse Model.” 2018. Masters Thesis, Utah State University. Accessed March 08, 2021. https://digitalcommons.usu.edu/etd/7278.

MLA Handbook (7^th Edition):

Peterson, Christopher. “Evaluation of Therapeutics for an Enterovirus 71 Infection in an AG129 Mouse Model.” 2018. Web. 08 Mar 2021.

Vancouver:

Peterson C. Evaluation of Therapeutics for an Enterovirus 71 Infection in an AG129 Mouse Model. [Internet] [Masters thesis]. Utah State University; 2018. [cited 2021 Mar 08]. Available from: https://digitalcommons.usu.edu/etd/7278.

Council of Science Editors:

Peterson C. Evaluation of Therapeutics for an Enterovirus 71 Infection in an AG129 Mouse Model. [Masters Thesis]. Utah State University; 2018. Available from: https://digitalcommons.usu.edu/etd/7278

Michigan State University

25. Regmi, Prafulla. Influence of housing systems on bone properties of laying hens.

Degree: 2015, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:3536

►

Thesis Ph. D. Michigan State University. Animal Science 2015.

Osteoporosis in caged hens is one driving factor for the U. S. egg industry to explore… (more)

▼

Thesis Ph. D. Michigan State University. Animal Science 2015.

Osteoporosis in caged hens is one driving factor for the U. S. egg industry to explore options regarding alternative housing systems for laying hens. The aim of this dissertation was to determine the housing system effects on bone quality of laying hens. The first study looked at tibiae and humeri of White Leghorn pullets reared in conventional cages (CC) and a cage-free aviary system (AV). At 16 wk, 120 birds were randomly sampled from each housing system for bone property analysis. Humeri and distal tibiae cortical density was greater in AV pullets compared to CC pullets (P < 0.05). Tibiae and humeri of AV pullets had a thicker cortex than the CC pullets (P < 0.05). Additionally, the tibiae and humeri of AV pullets had greater (P < 0.05) second moment of areas than the CC pullets. The aim of the second experiment was to study the influence of housing systems on 77 wk White Leghorn hens. Pullets raised in an aviary system were either continued in aviary hen systems (AV) or conventional cages (AC) whereas pullets reared in conventional cages continued in conventional hen cages (CC) or enriched colony cages (EN) at 19 wk. From each group, 120 hens were sampled at random for bone property analysis. Aviary (AV) hens had greater cortical thickness and density but similar outer dimensions to AC hens (P < 0.05). Hens in EN system had humeri with similar cortical thickness and density but wider outer dimensions than humeri of CC hens (P < 0.05). The follow-up study aimed at analyzing age-related changes in bone properties in different commercial housing systems. Pullets reared in conventional cages (CC) were continued in CC or moved to enriched colony cages (EN) at 19 wk whereas those reared in cage-free aviary (AV) were moved to AV hen houses. Bone samples were collected from 60 hens at 18 and 72 wk and 30 hens at 26 and 56 wk from each housing system. AV pullets had 41% greater humeri and 19% greater tibiae cortical area than CC pullets (P < 0.05). Humeri and tibiae of AV pullets had greater stiffness (31% and 7% respectively). The geometrical and biomechanical differences between bones of AV and CC hens persisted throughout the laying cycle. Moving CC pullets to EN resulted in decreased endosteal resorption in humeri evident by 7.5% greater cortical area of EN hens (P < 0.05). Stiffness increased with age in both tibiae and humeri while energy to failure decreased. The final study was aimed at determining the housing system and strain effects on bone quality parameters. Tibia, femur, and keel of Hy-Line Brown (HB), Hy-Line Silver Brown (SB) and Barred Plymouth Rock (BR) hens housed in conventional cages (CC), cage-free (CF) and cage-free with range access (R) were studied. Bone samples were collected from sixty hens from each strain and housing combination for analysis. Tibia cortical thickness was greater (P < 0.01) in BR than HB and SB. Between housing systems, thickness was greater (P < 0.05) for mid and distal tibia for R and CF compared to CC. Tibiae…

Advisors/Committee Members: Karcher, Darrin M, Nielsen, Brian D, Korver, Doug R, Orth, Michael W, Siegford, Janice M, Nelson, Nathan.

Subjects/Keywords: Hens – Housing; Hens – Diseases; Osteoporosis; Animal sciences

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Regmi, P. (2015). Influence of housing systems on bone properties of laying hens. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:3536

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Regmi, Prafulla. “Influence of housing systems on bone properties of laying hens.” 2015. Thesis, Michigan State University. Accessed March 08, 2021. http://etd.lib.msu.edu/islandora/object/etd:3536.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Regmi, Prafulla. “Influence of housing systems on bone properties of laying hens.” 2015. Web. 08 Mar 2021.

Vancouver:

Regmi P. Influence of housing systems on bone properties of laying hens. [Internet] [Thesis]. Michigan State University; 2015. [cited 2021 Mar 08]. Available from: http://etd.lib.msu.edu/islandora/object/etd:3536.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Regmi P. Influence of housing systems on bone properties of laying hens. [Thesis]. Michigan State University; 2015. Available from: http://etd.lib.msu.edu/islandora/object/etd:3536

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

26. Cross, Tiffanie A. Ecology of the interior population of double-crested cormorants : prevalence of disease and colony attendance.

Degree: 2013, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:1398

►

Thesis M.S. Michigan State University, Fisheries and Wildlife 2013.

The interior population of double-crested cormorants (Phalacrocorax auritus) nesting on the Great Lakes were nearly listed… (more)

Subjects/Keywords: Double-crested cormorant – Ecology; Double-crested cormorant – Diseases; Wildlife management; Animal diseases; Animal behavior

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cross, T. A. (2013). Ecology of the interior population of double-crested cormorants : prevalence of disease and colony attendance. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:1398

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cross, Tiffanie A. “Ecology of the interior population of double-crested cormorants : prevalence of disease and colony attendance.” 2013. Thesis, Michigan State University. Accessed March 08, 2021. http://etd.lib.msu.edu/islandora/object/etd:1398.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cross, Tiffanie A. “Ecology of the interior population of double-crested cormorants : prevalence of disease and colony attendance.” 2013. Web. 08 Mar 2021.

Vancouver:

Cross TA. Ecology of the interior population of double-crested cormorants : prevalence of disease and colony attendance. [Internet] [Thesis]. Michigan State University; 2013. [cited 2021 Mar 08]. Available from: http://etd.lib.msu.edu/islandora/object/etd:1398.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cross TA. Ecology of the interior population of double-crested cormorants : prevalence of disease and colony attendance. [Thesis]. Michigan State University; 2013. Available from: http://etd.lib.msu.edu/islandora/object/etd:1398

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Western Ontario

27. Tenn, Neil A. Investigating The Mechanism Of Ectopic Mineralization In A Mouse Model Of Diffuse Idiopathic Skeletal Hyperostosis (DISH).

Degree: 2015, University of Western Ontario

URL: https://ir.lib.uwo.ca/etd/2966

► Equilibrative nucleoside transporter 1 (ENT1) transfers adenosine across plasma membranes. Mice lacking ENT1 (ENT1-/-) develop pathological calcification of spinal tissues resembling diffuse idiopathic skeletal hyperostosis… (more)

Subjects/Keywords: Animal Diseases; Musculoskeletal Diseases; Pathological Conditions, Signs and Symptoms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tenn, N. A. (2015). Investigating The Mechanism Of Ectopic Mineralization In A Mouse Model Of Diffuse Idiopathic Skeletal Hyperostosis (DISH). (Thesis). University of Western Ontario. Retrieved from https://ir.lib.uwo.ca/etd/2966

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tenn, Neil A. “Investigating The Mechanism Of Ectopic Mineralization In A Mouse Model Of Diffuse Idiopathic Skeletal Hyperostosis (DISH).” 2015. Thesis, University of Western Ontario. Accessed March 08, 2021. https://ir.lib.uwo.ca/etd/2966.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tenn, Neil A. “Investigating The Mechanism Of Ectopic Mineralization In A Mouse Model Of Diffuse Idiopathic Skeletal Hyperostosis (DISH).” 2015. Web. 08 Mar 2021.

Vancouver:

Tenn NA. Investigating The Mechanism Of Ectopic Mineralization In A Mouse Model Of Diffuse Idiopathic Skeletal Hyperostosis (DISH). [Internet] [Thesis]. University of Western Ontario; 2015. [cited 2021 Mar 08]. Available from: https://ir.lib.uwo.ca/etd/2966.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tenn NA. Investigating The Mechanism Of Ectopic Mineralization In A Mouse Model Of Diffuse Idiopathic Skeletal Hyperostosis (DISH). [Thesis]. University of Western Ontario; 2015. Available from: https://ir.lib.uwo.ca/etd/2966

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Michigan State University

28. DeKuiper, Justin Lee. Inflammatory TH17 responses to infection with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle and their potential role in the development of Johne's disease.

Degree: 2019, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:48303

►

Thesis Ph. D. Michigan State University. Animal Science 2019.

Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic inflammatory gastrointestinal disease of ruminants known as Johne’s… (more)

▼

Thesis Ph. D. Michigan State University. Animal Science 2019.

Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic inflammatory gastrointestinal disease of ruminants known as Johne’s disease (JD). MAP primarily colonizes the ileum of ruminants, leading to reduced nutrient absorption, chronic diarrhea, and eventually death. The percentage of dairy operations infected MAP in the US may have risen to as much as 91% from earlier reports of 68%. In correspondence, an estimated dairy industry loss has increased from 200 million to 1.5 billion was due to JD. Control of JD is difficult largely due to insensitive diagnostic tools, a long subclinical stage of infection, and lack of effective vaccines. Correlates of protection are lacking in model systems of JD and the sources of inflammation due to JD are not well characterized. Inside macrophages, MAP survives and replicates. Monocyte-derived macrophages (MDMs), peripheral blood mononuclear cells (PBMCs), and various T-cells interact with MAP. Commonly studied immune responses, such as the Th1/Th2 paradigm, do not adequately explain host responses to MAP. The major remaining knowledge gaps in MAP immunopathogenesis include key inflammatory responders in the ileum, and how naïve T-cell responsive choice (Th1, Th2, Th17) is influenced. A potential role for non-classical immune responses to MAP, such as that mediated by Th17 cells, has been suggested. Indeed, MAP antigens induce mRNAs encoding the cytokines IL-23 and IL-17A in bovine PBMCs. IL-23 and IL-17A production are both associated with Th17-like immune responses. Th17 cells are also defined by surface expression of the IL-23 receptor (IL-23R). The mean relative percent (MRP) of T cell subtypes expressing IL-23R was determined by flow cytometry and indicated an increase in mean relative percent (MRP) of T cells (CD4+, CD8+, and TCR1+) in peripheral blood mononuclear cells (PBMCs) of JD+ cows with high and low expression of IL-23R (IL-23RHigh and IL-23RLow) when compared to JD- cows. Although MAP stimulates PBMCs to secrete IL-17A in-vitro, there were no differences in IL-17A levels between subclinical JD+ and JD- cows when analyzed by ELISA. Plasma with low JD+ score values had significantly more IL-17A when compared to plasma with high JD+ score values, establishing a moderate correlation between JD+ score and IL-17A. However, overall plasma from JD+ cows had significantly less IL-17A than plasma from JD- cows. Unlike IL-17A, IL-23 was greater in plasma from JD+ cows than in JD- cows. Evaluating the relationship that MAP is having on APCs and CD3+ in relation to Th17 cytokines (IL-23, IL-17A, IL-17F, IL-22, IL-27) as well as Th1 cytokine IFNγ, CD3+ were stimulated with MAP in the presence of APCs (MDMs or B cells) or alone and evaluated by RT-qPCR. MAP stimulation significantly increased production of mRNA encoding Th17 cytokines and IFNγ in CD3+ T cells regardless of APCs. However, the presence of MDMs significantly increase the quantity of mRNA. Lastly, we observed that αβ T cells (mostly CD4+)…

Advisors/Committee Members: Coussens, Paul M, Steibel, Juan, Petroff, Peggy, Norby, Bo.

Subjects/Keywords: Mycobacterium avium paratuberculosis; Paratuberculosis; Cattle – Diseases; Immunology; Animal diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

DeKuiper, J. L. (2019). Inflammatory TH17 responses to infection with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle and their potential role in the development of Johne's disease. (Thesis). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:48303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DeKuiper, Justin Lee. “Inflammatory TH17 responses to infection with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle and their potential role in the development of Johne's disease.” 2019. Thesis, Michigan State University. Accessed March 08, 2021. http://etd.lib.msu.edu/islandora/object/etd:48303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DeKuiper, Justin Lee. “Inflammatory TH17 responses to infection with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle and their potential role in the development of Johne's disease.” 2019. Web. 08 Mar 2021.

Vancouver:

DeKuiper JL. Inflammatory TH17 responses to infection with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle and their potential role in the development of Johne's disease. [Internet] [Thesis]. Michigan State University; 2019. [cited 2021 Mar 08]. Available from: http://etd.lib.msu.edu/islandora/object/etd:48303.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DeKuiper JL. Inflammatory TH17 responses to infection with Mycobacterium avium subspecies paratuberculosis (MAP) in cattle and their potential role in the development of Johne's disease. [Thesis]. Michigan State University; 2019. Available from: http://etd.lib.msu.edu/islandora/object/etd:48303

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

West Virginia University

29. Dow, Tina Lynn. Effects of induced acute phase response in ewes on early embryo survival.

Degree: MS, Animal and Nutritional Sciences, 2008, West Virginia University

URL: https://doi.org/10.33915/etd.4366 ; https://researchrepository.wvu.edu/etd/4366

► Early pregnant ewes, 5/6 day post coitus (dpc) were used as a model to study early embryonic loss via gram-positive bacterial infections, such as mastitis.… (more)

▼ Early pregnant ewes, 5/6 day post coitus (dpc) were used as a model to study early embryonic loss via gram-positive bacterial infections, such as mastitis. Ewes 5/6 dpc were injected with a gram-positive bacteria cell wall component, peptidoglycan-polysaccharide (PG-PS), to induce an innate immune system acute phase response (APR). The induction of the APR and its reactant molecules, such as cytokines and acute phase proteins (APP), were initiated to study their effects on embryonic loss. Twenty Suffolk ewes were synchronized for estrus and bred by fertile rams. At 4 dpc ewes were anesthetized and catheters were surgically placed in the right rear leg in the caudal vena cava via saphenous vein, as well as in the jugular. Ewes were randomly assigned to treatment groups on 5 dpc, and received either a 60 mug/kg BW dose of PG-PS (n=10) or a sham injection of 0.9% NaCl (n=10) i.v. in the jugular vein contralateral of the catheter. Plasma was collected from jugular and caudal vena cava via the saphenous vein before challenge, followed by post challenge samples every 15 minutes until 2 hours, every hour until 12 hours, and once at 24, 36, and 48 hours. Assays were conducted for APR reactants tumor necrosis factor-alpha (TNF-alpha), serum amyloid A (SAA), and haptoglobin (Hp), as well as the pregnancy maintenance hormone, progesterone (P4). In addition, behavior changes and body temperature were also documented before PG-PS injection followed by every hour for 12 hours and then again at 24, 36, and 48 post challenge. Concentrations of TNF-alpha and P4 were quantified using radioimmunoassay, whereas ELISA was used to measure SAA and HP concentrations. Intoxication of day 5/6 pregnant ewes with 60 mug/kg BW PG-PS induced significant differences in TNF-alpha concentration between sample sites (p<0.001) and treatment groups (p<0.02). SAA and Hp concentrations increased significantly (p<0.0001) in challenged ewes. Fever, loss of appetite, lethargy, and vaginal discharge were documented in all treated ewes, as well as 100 % embryonic loss by 21 dpc. Data from this experiment demonstrate that injection of PG-PS systemically leads to production of APP and behavioral changes characteristic of an APR. Advisors/Committee Members: Robert A Dailey.

Subjects/Keywords: Animal Physiology; Animal diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dow, T. L. (2008). Effects of induced acute phase response in ewes on early embryo survival. (Thesis). West Virginia University. Retrieved from https://doi.org/10.33915/etd.4366 ; https://researchrepository.wvu.edu/etd/4366

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dow, Tina Lynn. “Effects of induced acute phase response in ewes on early embryo survival.” 2008. Thesis, West Virginia University. Accessed March 08, 2021. https://doi.org/10.33915/etd.4366 ; https://researchrepository.wvu.edu/etd/4366.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dow, Tina Lynn. “Effects of induced acute phase response in ewes on early embryo survival.” 2008. Web. 08 Mar 2021.

Vancouver:

Dow TL. Effects of induced acute phase response in ewes on early embryo survival. [Internet] [Thesis]. West Virginia University; 2008. [cited 2021 Mar 08]. Available from: https://doi.org/10.33915/etd.4366 ; https://researchrepository.wvu.edu/etd/4366.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dow TL. Effects of induced acute phase response in ewes on early embryo survival. [Thesis]. West Virginia University; 2008. Available from: https://doi.org/10.33915/etd.4366 ; https://researchrepository.wvu.edu/etd/4366

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

West Virginia University

30. Rogers, Gabrielle Marie. Tumor necrosis factor-alpha production induced by peptidoglycan-polysaccharide in early pregnant ewes.

Degree: MS, Biochemistry, 2006, West Virginia University

URL: https://doi.org/10.33915/etd.4261 ; https://researchrepository.wvu.edu/etd/4261

► Peptidoglycan-polysaccharide (PG-PS), cell wall component of gram-positive bacteria, was used to intoxicate sheep to study mastitis-related reproductive failure, mediated by TNF-alpha. Estrus was synchronized in… (more)

Subjects/Keywords: Animal Physiology; Animal diseases

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rogers, G. M. (2006). Tumor necrosis factor-alpha production induced by peptidoglycan-polysaccharide in early pregnant ewes. (Thesis). West Virginia University. Retrieved from https://doi.org/10.33915/etd.4261 ; https://researchrepository.wvu.edu/etd/4261

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rogers, Gabrielle Marie. “Tumor necrosis factor-alpha production induced by peptidoglycan-polysaccharide in early pregnant ewes.” 2006. Thesis, West Virginia University. Accessed March 08, 2021. https://doi.org/10.33915/etd.4261 ; https://researchrepository.wvu.edu/etd/4261.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rogers, Gabrielle Marie. “Tumor necrosis factor-alpha production induced by peptidoglycan-polysaccharide in early pregnant ewes.” 2006. Web. 08 Mar 2021.

Vancouver:

Rogers GM. Tumor necrosis factor-alpha production induced by peptidoglycan-polysaccharide in early pregnant ewes. [Internet] [Thesis]. West Virginia University; 2006. [cited 2021 Mar 08]. Available from: https://doi.org/10.33915/etd.4261 ; https://researchrepository.wvu.edu/etd/4261.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rogers GM. Tumor necrosis factor-alpha production induced by peptidoglycan-polysaccharide in early pregnant ewes. [Thesis]. West Virginia University; 2006. Available from: https://doi.org/10.33915/etd.4261 ; https://researchrepository.wvu.edu/etd/4261

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations