subject:(Alkaloids)

1. Reyes, Jeremy Chris Punzalan. ???Bioinspired??? Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ???Metabiosynthetic??? Studies.

Degree: 2013, Texas Digital Library

URL: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66550

► Numerous marine-derived pyrrole 2-aminoimidazole alkaloids (P-2-AIs), including the highly potent antitumor natural product agelastatin A, are presumed to be derived from the simple precursor oroidin… (more)

Subjects/Keywords: alkaloids

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APA (6^th Edition):

Reyes, J. C. P. (2013). ???Bioinspired??? Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ???Metabiosynthetic??? Studies. (Thesis). Texas Digital Library. Retrieved from http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Reyes, Jeremy Chris Punzalan. “???Bioinspired??? Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ???Metabiosynthetic??? Studies.” 2013. Thesis, Texas Digital Library. Accessed March 02, 2021. http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Reyes, Jeremy Chris Punzalan. “???Bioinspired??? Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ???Metabiosynthetic??? Studies.” 2013. Web. 02 Mar 2021.

Vancouver:

Reyes JCP. ???Bioinspired??? Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ???Metabiosynthetic??? Studies. [Internet] [Thesis]. Texas Digital Library; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66550.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Reyes JCP. ???Bioinspired??? Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ???Metabiosynthetic??? Studies. [Thesis]. Texas Digital Library; 2013. Available from: http://hdl.handle.net/1969; http://hdl.handle.net/2249.1/66550

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

2. Maumela, Munaka Christopher. Synthetic approaches to the alkaloids cycleanine, insularine and cissacapine.

Degree: PhD, 2012, University of Johannesburg

URL: http://hdl.handle.net/10210/5684

► The objective of the research described in this thesis was to develop a synthetic method that can be applied to the synthesis of the natural… (more)

▼ The objective of the research described in this thesis was to develop a synthetic method that can be applied to the synthesis of the natural bisbenzyltetrahydroisoquinoline alkaloids cissacapine, insularine, insularoline, cycleanine and analogues thereof. In this study two different strategies that allow easy entry to the precursors of these alkaloids were developed, and these set the scene for future total synthesis of these alkaloids. The key features of the first approach comprise the linkage of the two appropriate rings to form the diaryl ether moiety as well as the preparation of the 11H-dibenzo[b,e][1,4]dioxepine tricyclic system. Previous approaches to the diaryl ether formation are not suitable for large-scale reactions. We have herein described the preparation of the diaryl ether precursors in high yields and our approach is suitable for large-scale preparations. A search of the literature method revealed only two published methods for the preparation of the 11H-dibenzo[b,e][1,4]dioxepine system. Both these two methods produce compounds containing this moiety in low yields. In our studies this aspect was addressed satisfactorily. Unfortunately, our attempts to complete the synthesis of these alkaloids through Bischler-Napieralski reaction was met with no success, the problem been ascribed to the unoptimised Bischler-Napieralski conditions used. Our second approach involves the preparation of benzylisoquinoline units that are precursors of cycleanine. The published method to the derivatives of the cycleanine precursors is non-stereopecific and produces racemic benzylisoquinolines. Our synthetic route is a chiral auxiliary-based asymmetric version that produces the optically-pure benzylisoquinoline monomers. The key features of this route involve incorporation of the chiral auxiliary on the nitrogen atom, Bischler-Napieralski cyclisation of the resultant chiral amides and finally stereoselective reduction of the 3,4-dihydroisoquinolinium ion possessing the chiral auxiliary. This route employs both optically-pure (S)- and (R)-1-phenethylamine as the chiral source. Optically pure diastereomers were obtained. Our approach is a vast improvement compared to the previously described non-stereospecific method since it allows easy and good stereoselective access to both diastereomers in good yield. Unfortunately, one of the concluding steps leading to the formation of the dimeric stereoisomers of cycleanine through diaryl ether formation using the recently published methods was not successful. This is ascribed to the electron-rich nature of the isoquinoline ring.

Subjects/Keywords: Alkaloids; Alkaloids - Synthesis

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APA (6^th Edition):

Maumela, M. C. (2012). Synthetic approaches to the alkaloids cycleanine, insularine and cissacapine. (Doctoral Dissertation). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/5684

Chicago Manual of Style (16^th Edition):

Maumela, Munaka Christopher. “Synthetic approaches to the alkaloids cycleanine, insularine and cissacapine.” 2012. Doctoral Dissertation, University of Johannesburg. Accessed March 02, 2021. http://hdl.handle.net/10210/5684.

MLA Handbook (7^th Edition):

Maumela, Munaka Christopher. “Synthetic approaches to the alkaloids cycleanine, insularine and cissacapine.” 2012. Web. 02 Mar 2021.

Vancouver:

Maumela MC. Synthetic approaches to the alkaloids cycleanine, insularine and cissacapine. [Internet] [Doctoral dissertation]. University of Johannesburg; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10210/5684.

Council of Science Editors:

Maumela MC. Synthetic approaches to the alkaloids cycleanine, insularine and cissacapine. [Doctoral Dissertation]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/5684

University of Hong Kong

3. Ng, Yuk-lin. New alkaloids from zanthozylumspecies of Hong Kong.

Degree: 1959, University of Hong Kong

URL: http://hdl.handle.net/10722/55401

Subjects/Keywords: Alkaloids.

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APA (6^th Edition):

Ng, Y. (1959). New alkaloids from zanthozylumspecies of Hong Kong. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/55401

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ng, Yuk-lin. “New alkaloids from zanthozylumspecies of Hong Kong.” 1959. Thesis, University of Hong Kong. Accessed March 02, 2021. http://hdl.handle.net/10722/55401.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ng, Yuk-lin. “New alkaloids from zanthozylumspecies of Hong Kong.” 1959. Web. 02 Mar 2021.

Vancouver:

Ng Y. New alkaloids from zanthozylumspecies of Hong Kong. [Internet] [Thesis]. University of Hong Kong; 1959. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10722/55401.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ng Y. New alkaloids from zanthozylumspecies of Hong Kong. [Thesis]. University of Hong Kong; 1959. Available from: http://hdl.handle.net/10722/55401

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

4. Clezy, Peter Steele. Studies in the field of bisbenzylisoquinoline alkaloids.

Degree: 1955, University of Tasmania

URL: https://eprints.utas.edu.au/18912/1/whole_ClezyPeterSteele1955_thesis.pdf

► Atherospermine, the major base of Atherosoerma moschatum, has been shown to be identical with berbamine and the phenolic group in this base has been placed… (more)

Subjects/Keywords: Alkaloids

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APA (6^th Edition):

Clezy, P. S. (1955). Studies in the field of bisbenzylisoquinoline alkaloids. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/18912/1/whole_ClezyPeterSteele1955_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Clezy, Peter Steele. “Studies in the field of bisbenzylisoquinoline alkaloids.” 1955. Thesis, University of Tasmania. Accessed March 02, 2021. https://eprints.utas.edu.au/18912/1/whole_ClezyPeterSteele1955_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Clezy, Peter Steele. “Studies in the field of bisbenzylisoquinoline alkaloids.” 1955. Web. 02 Mar 2021.

Vancouver:

Clezy PS. Studies in the field of bisbenzylisoquinoline alkaloids. [Internet] [Thesis]. University of Tasmania; 1955. [cited 2021 Mar 02]. Available from: https://eprints.utas.edu.au/18912/1/whole_ClezyPeterSteele1955_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Clezy PS. Studies in the field of bisbenzylisoquinoline alkaloids. [Thesis]. University of Tasmania; 1955. Available from: https://eprints.utas.edu.au/18912/1/whole_ClezyPeterSteele1955_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

5. Wiriyachitra, Pichaet. Some structural and photochemical studies of isoquinoline alkaloids and related systems.

Degree: 1972, University of Tasmania

URL: https://eprints.utas.edu.au/21800/1/whole_WiriyachitraPichaet1972_thesis.pdf

Subjects/Keywords: Alkaloids

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APA (6^th Edition):

Wiriyachitra, P. (1972). Some structural and photochemical studies of isoquinoline alkaloids and related systems. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/21800/1/whole_WiriyachitraPichaet1972_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wiriyachitra, Pichaet. “Some structural and photochemical studies of isoquinoline alkaloids and related systems.” 1972. Thesis, University of Tasmania. Accessed March 02, 2021. https://eprints.utas.edu.au/21800/1/whole_WiriyachitraPichaet1972_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wiriyachitra, Pichaet. “Some structural and photochemical studies of isoquinoline alkaloids and related systems.” 1972. Web. 02 Mar 2021.

Vancouver:

Wiriyachitra P. Some structural and photochemical studies of isoquinoline alkaloids and related systems. [Internet] [Thesis]. University of Tasmania; 1972. [cited 2021 Mar 02]. Available from: https://eprints.utas.edu.au/21800/1/whole_WiriyachitraPichaet1972_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wiriyachitra P. Some structural and photochemical studies of isoquinoline alkaloids and related systems. [Thesis]. University of Tasmania; 1972. Available from: https://eprints.utas.edu.au/21800/1/whole_WiriyachitraPichaet1972_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manitoba

6. Almalki, Manal. Isolation and characterization of Steroidal Alkaloids from Buxus macowanii using chromatographic and spectroscopic methods.

Degree: Chemistry, 2014, University of Manitoba

URL: http://hdl.handle.net/1993/24080

► This thesis describes the isolation and characterization of four steroidal alkaloids from Buxus macowanii. Phytochemical investigation of Buxus macowanii resulted in the isolation of two… (more)

Subjects/Keywords: alkaloids; acetylcholinesterase

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APA (6^th Edition):

Almalki, M. (2014). Isolation and characterization of Steroidal Alkaloids from Buxus macowanii using chromatographic and spectroscopic methods. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/24080

Chicago Manual of Style (16^th Edition):

Almalki, Manal. “Isolation and characterization of Steroidal Alkaloids from Buxus macowanii using chromatographic and spectroscopic methods.” 2014. Masters Thesis, University of Manitoba. Accessed March 02, 2021. http://hdl.handle.net/1993/24080.

MLA Handbook (7^th Edition):

Almalki, Manal. “Isolation and characterization of Steroidal Alkaloids from Buxus macowanii using chromatographic and spectroscopic methods.” 2014. Web. 02 Mar 2021.

Vancouver:

Almalki M. Isolation and characterization of Steroidal Alkaloids from Buxus macowanii using chromatographic and spectroscopic methods. [Internet] [Masters thesis]. University of Manitoba; 2014. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1993/24080.

Council of Science Editors:

Almalki M. Isolation and characterization of Steroidal Alkaloids from Buxus macowanii using chromatographic and spectroscopic methods. [Masters Thesis]. University of Manitoba; 2014. Available from: http://hdl.handle.net/1993/24080

University of Adelaide

7. Halleday, John Arthur. Approaches towards the synthesis of Galbulimima Alkaloids.

Degree: 1970, University of Adelaide

URL: http://hdl.handle.net/2440/20106

Subjects/Keywords: Alkaloids.

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APA (6^th Edition):

Halleday, J. A. (1970). Approaches towards the synthesis of Galbulimima Alkaloids. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/20106

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Halleday, John Arthur. “Approaches towards the synthesis of Galbulimima Alkaloids.” 1970. Thesis, University of Adelaide. Accessed March 02, 2021. http://hdl.handle.net/2440/20106.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Halleday, John Arthur. “Approaches towards the synthesis of Galbulimima Alkaloids.” 1970. Web. 02 Mar 2021.

Vancouver:

Halleday JA. Approaches towards the synthesis of Galbulimima Alkaloids. [Internet] [Thesis]. University of Adelaide; 1970. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2440/20106.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Halleday JA. Approaches towards the synthesis of Galbulimima Alkaloids. [Thesis]. University of Adelaide; 1970. Available from: http://hdl.handle.net/2440/20106

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Hong Kong

8. 陳寶娟. Alkaloids from Hong Kong plants.

Degree: 1962, University of Hong Kong

URL: http://hdl.handle.net/10722/37481

Subjects/Keywords: Alkaloids.

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APA (6^th Edition):

陳寶娟. (1962). Alkaloids from Hong Kong plants. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/37481

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

陳寶娟. “Alkaloids from Hong Kong plants.” 1962. Thesis, University of Hong Kong. Accessed March 02, 2021. http://hdl.handle.net/10722/37481.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

陳寶娟. “Alkaloids from Hong Kong plants.” 1962. Web. 02 Mar 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete

Vancouver:

陳寶娟. Alkaloids from Hong Kong plants. [Internet] [Thesis]. University of Hong Kong; 1962. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10722/37481.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

陳寶娟. Alkaloids from Hong Kong plants. [Thesis]. University of Hong Kong; 1962. Available from: http://hdl.handle.net/10722/37481

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation

University of British Columbia

9. Fortes, Carlos Camiza. The total synthesis of veratrum alkaloids.

Degree: PhD, Chemistry, 1973, University of British Columbia

URL: http://hdl.handle.net/2429/19070

► The condensation of a C-nor-D-homo steroidal portion with the lithium derivative of various substituted pyridines is outlined as a general method for the synthesis of… (more)

Subjects/Keywords: Alkaloids

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APA (6^th Edition):

Fortes, C. C. (1973). The total synthesis of veratrum alkaloids. (Doctoral Dissertation). University of British Columbia. Retrieved from http://hdl.handle.net/2429/19070

Chicago Manual of Style (16^th Edition):

Fortes, Carlos Camiza. “The total synthesis of veratrum alkaloids.” 1973. Doctoral Dissertation, University of British Columbia. Accessed March 02, 2021. http://hdl.handle.net/2429/19070.

MLA Handbook (7^th Edition):

Fortes, Carlos Camiza. “The total synthesis of veratrum alkaloids.” 1973. Web. 02 Mar 2021.

Vancouver:

Fortes CC. The total synthesis of veratrum alkaloids. [Internet] [Doctoral dissertation]. University of British Columbia; 1973. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2429/19070.

Council of Science Editors:

Fortes CC. The total synthesis of veratrum alkaloids. [Doctoral Dissertation]. University of British Columbia; 1973. Available from: http://hdl.handle.net/2429/19070

University of British Columbia

10. Gletsos, Constantie. Synthetic studies in indole alkaloids.

Degree: PhD, Chemistry, 1968, University of British Columbia

URL: http://hdl.handle.net/2429/36117

► The total synthesis of a variety of indole and dihydroindole alkaloids, is described. Mere specifically, the d1-epimers of naturally occurring vincadine, vincaminoreine, vincaminorine, minovine, vincadifformine,… (more)

Subjects/Keywords: Alkaloids

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APA (6^th Edition):

Gletsos, C. (1968). Synthetic studies in indole alkaloids. (Doctoral Dissertation). University of British Columbia. Retrieved from http://hdl.handle.net/2429/36117

Chicago Manual of Style (16^th Edition):

Gletsos, Constantie. “Synthetic studies in indole alkaloids.” 1968. Doctoral Dissertation, University of British Columbia. Accessed March 02, 2021. http://hdl.handle.net/2429/36117.

MLA Handbook (7^th Edition):

Gletsos, Constantie. “Synthetic studies in indole alkaloids.” 1968. Web. 02 Mar 2021.

Vancouver:

Gletsos C. Synthetic studies in indole alkaloids. [Internet] [Doctoral dissertation]. University of British Columbia; 1968. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2429/36117.

Council of Science Editors:

Gletsos C. Synthetic studies in indole alkaloids. [Doctoral Dissertation]. University of British Columbia; 1968. Available from: http://hdl.handle.net/2429/36117

Michigan State University

11. Titus, Richard Lee, 1934-. The preparation of some 3,6- and 3,4-disubstituted thianaphthenes.

Degree: PhD, Department of Chemistry, 1964, Michigan State University

URL: http://etd.lib.msu.edu/islandora/object/etd:37756

Subjects/Keywords: Alkaloids

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APA (6^th Edition):

Titus, Richard Lee, 1. (1964). The preparation of some 3,6- and 3,4-disubstituted thianaphthenes. (Doctoral Dissertation). Michigan State University. Retrieved from http://etd.lib.msu.edu/islandora/object/etd:37756

Chicago Manual of Style (16^th Edition):

Titus, Richard Lee, 1934-. “The preparation of some 3,6- and 3,4-disubstituted thianaphthenes.” 1964. Doctoral Dissertation, Michigan State University. Accessed March 02, 2021. http://etd.lib.msu.edu/islandora/object/etd:37756.

MLA Handbook (7^th Edition):

Titus, Richard Lee, 1934-. “The preparation of some 3,6- and 3,4-disubstituted thianaphthenes.” 1964. Web. 02 Mar 2021.

Vancouver:

Titus, Richard Lee 1. The preparation of some 3,6- and 3,4-disubstituted thianaphthenes. [Internet] [Doctoral dissertation]. Michigan State University; 1964. [cited 2021 Mar 02]. Available from: http://etd.lib.msu.edu/islandora/object/etd:37756.

Council of Science Editors:

Titus, Richard Lee 1. The preparation of some 3,6- and 3,4-disubstituted thianaphthenes. [Doctoral Dissertation]. Michigan State University; 1964. Available from: http://etd.lib.msu.edu/islandora/object/etd:37756

University of Johannesburg

12. Greyling, Hendrik Frederik. Die sintese van alkaloiedagtige glikosidase-inhibeerders vanuit monosakkariede.

Degree: 2014, University of Johannesburg

URL: http://hdl.handle.net/10210/10917

►

M.Sc. (Chemistry)

The aim of this study was to investigate alternative routes for the stereocontrolled synthesis of hydroxylated indolizidine, piperidine and pyrrolidine alkaloids, starting from… (more)

▼

M.Sc. (Chemistry)

The aim of this study was to investigate alternative routes for the stereocontrolled synthesis of hydroxylated indolizidine, piperidine and pyrrolidine alkaloids, starting from monosaccharides as chiral building blocks. This study was not aimed at improving consisting routes - it was rather aimed at developing new routes towards the synthesis of these alkaloids. Mixed results were obtained in the investigation into alternative routes for the synthesis of the bicyclic poly hydroxylated indolizidine alkaloids, but a new and efficient stereospecific synthesis of polyhydroxylated piperidine- and pyrrolidine alkaloids were developed. The aims and results can be summarised in more detail as follows: a. Stereospecific synthesis of castanospermine. The synthesis of this medium sized nitrogen-containing bicyclic molecule was approached in a unique way. The utilization of bifunctional Wittig- and Wittig-Horner reagents containing nitrogen functionalities was considered promising for the aims of this study. By the usage of known reactions, e.g. Wittig, Wittig-Horner, Schiff-base and Aza-Wittig reactions, it was foreseen that these bifunctional reagents could be coupled in two concurrent steps to dicarbonyl compounds to form a nitrogen containing rings. Several nitrogen containing Wittig reagents were prepared. At the one end of these reagents a phosphonate or phosphine group furnished the phosphorus moiety while the other end of these reagents comprised the nitrogen moiety by reduction of a nitrile group or azide displacement of a leaving group. No coupling was obtained between these bifunctional reagents and a dicarbonyl compound derived from D-glucose and the influence of two functional groups in such close proximity in the Wittig reagent is being further investigated. Coupling was, however, achieved by the utilization of an alternative bifunctional reagent in which a Wittig-Horner reaction was used. The successful implementation of this unique methodology in the synthesis of medium size nitrogen containing ring is being further investigated.

Subjects/Keywords: Alkaloids - Synthesis; Indole alkaloids; Pyrrolidine; Piperidine

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APA (6^th Edition):

Greyling, H. F. (2014). Die sintese van alkaloiedagtige glikosidase-inhibeerders vanuit monosakkariede. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/10917

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Greyling, Hendrik Frederik. “Die sintese van alkaloiedagtige glikosidase-inhibeerders vanuit monosakkariede.” 2014. Thesis, University of Johannesburg. Accessed March 02, 2021. http://hdl.handle.net/10210/10917.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Greyling, Hendrik Frederik. “Die sintese van alkaloiedagtige glikosidase-inhibeerders vanuit monosakkariede.” 2014. Web. 02 Mar 2021.

Vancouver:

Greyling HF. Die sintese van alkaloiedagtige glikosidase-inhibeerders vanuit monosakkariede. [Internet] [Thesis]. University of Johannesburg; 2014. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10210/10917.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Greyling HF. Die sintese van alkaloiedagtige glikosidase-inhibeerders vanuit monosakkariede. [Thesis]. University of Johannesburg; 2014. Available from: http://hdl.handle.net/10210/10917

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Columbia University

13. Smith, Myles Warwick. Strategies for the Concise Synthesis of the Akuammiline Alkaloids.

Degree: 2015, Columbia University

URL: https://doi.org/10.7916/D8BK1B49

► The akuammiline alkaloids are an intriguing class of natural products that display an array of biological activities and structural diversity. Despite being known for over… (more)

Subjects/Keywords: Alkaloids – Synthesis; Chemistry; Alkaloids; Chemistry, Organic

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APA (6^th Edition):

Smith, M. W. (2015). Strategies for the Concise Synthesis of the Akuammiline Alkaloids. (Doctoral Dissertation). Columbia University. Retrieved from https://doi.org/10.7916/D8BK1B49

Chicago Manual of Style (16^th Edition):

Smith, Myles Warwick. “Strategies for the Concise Synthesis of the Akuammiline Alkaloids.” 2015. Doctoral Dissertation, Columbia University. Accessed March 02, 2021. https://doi.org/10.7916/D8BK1B49.

MLA Handbook (7^th Edition):

Smith, Myles Warwick. “Strategies for the Concise Synthesis of the Akuammiline Alkaloids.” 2015. Web. 02 Mar 2021.

Vancouver:

Smith MW. Strategies for the Concise Synthesis of the Akuammiline Alkaloids. [Internet] [Doctoral dissertation]. Columbia University; 2015. [cited 2021 Mar 02]. Available from: https://doi.org/10.7916/D8BK1B49.

Council of Science Editors:

Smith MW. Strategies for the Concise Synthesis of the Akuammiline Alkaloids. [Doctoral Dissertation]. Columbia University; 2015. Available from: https://doi.org/10.7916/D8BK1B49

Oregon State University

14. Carlson, Erik (Erik Carlyle). Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis.

Degree: MS, Chemistry, 2010, Oregon State University

URL: http://hdl.handle.net/1957/14014

► Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form… (more)

Subjects/Keywords: Organocatalyzed; Alkaloids – Synthesis

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APA (6^th Edition):

Carlson, E. (. C. (2010). Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/14014

Chicago Manual of Style (16^th Edition):

Carlson, Erik (Erik Carlyle). “Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis.” 2010. Masters Thesis, Oregon State University. Accessed March 02, 2021. http://hdl.handle.net/1957/14014.

MLA Handbook (7^th Edition):

Carlson, Erik (Erik Carlyle). “Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis.” 2010. Web. 02 Mar 2021.

Vancouver:

Carlson E(C. Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis. [Internet] [Masters thesis]. Oregon State University; 2010. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1957/14014.

Council of Science Editors:

Carlson E(C. Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis. [Masters Thesis]. Oregon State University; 2010. Available from: http://hdl.handle.net/1957/14014

University of Tennessee – Knoxville

15. Brown, Michael Ryan. Agronomic Practices to Reduce Alkaloid Levels in Dark Fire-Cured Tobacco.

Degree: MS, Plant Sciences, 2018, University of Tennessee – Knoxville

URL: https://trace.tennessee.edu/utk_gradthes/5352

► Field experiments were conducted at two locations over two years to evaluate the effects of agronomic practices on physical and chemical properties of dark… (more)

▼ Field experiments were conducted at two locations over two years to evaluate the effects of agronomic practices on physical and chemical properties of dark fire-cured tobacco. Locations were at the Highland Rim Research and Education Center in Springfield, TN, and at the University of Kentucky Research and Education Center in Princeton, KY. One experiment was conducted in Springfield, TN, in 2016 and experiments were conducted at both locations in 2017. These experiments evaluated two dark tobacco varieties (KT D14 LC and KT D18 LI), two nitrogen rates (84 kg N/ha applied preplant and 196 kg N/ha - 84 kg applied preplant followed by 112 kg at layby), three topping stages (early button, late bloom, and immediately prior to harvest), and two sucker control methods (dropline application with fatty alcohol solution and hand-suckered). The 2017 experiments did not evaluate the sucker control treatments. Soil amendments, pest control, and all other production practices were carried out according to university recommendations. The effects of variety and nitrogen rate on yield were inconsistent. However, similar yield and quality was observed for both varieties when averaged across all years and locations. Leaf chemistry was inconsistent between both varieties. Reduction of nitrogen reduced alkaloids, nicotine, TSNA, and NNN, while earlier topping increased alkaloids, nicotine, TSNA, and NNN. However, results could have been influenced by the amount of days after topping until harvest. While topping immediately prior to harvest significantly reduced alkaloids, nicotine, TSNA, and NNN, this practice also severely decreased yield and quality. Leaf from higher stalk positions produced higher levels of all chemical constituents, except nicotine to nornicotine conversion and NNK. Conversely, lower stalk positions resulted in higher levels of nicotine to nornicotine conversion and NNK. Based on the results of this study, reduced nitrogen and later toppings decreased the amount of certain chemical constituents in the cured leaf. Advisors/Committee Members: Eric R. Walker, William A. Bailey, Robert D. Miller.

Subjects/Keywords: tobacco; alkaloids; TSNA

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APA (6^th Edition):

Brown, M. R. (2018). Agronomic Practices to Reduce Alkaloid Levels in Dark Fire-Cured Tobacco. (Thesis). University of Tennessee – Knoxville. Retrieved from https://trace.tennessee.edu/utk_gradthes/5352

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Brown, Michael Ryan. “Agronomic Practices to Reduce Alkaloid Levels in Dark Fire-Cured Tobacco.” 2018. Thesis, University of Tennessee – Knoxville. Accessed March 02, 2021. https://trace.tennessee.edu/utk_gradthes/5352.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Brown, Michael Ryan. “Agronomic Practices to Reduce Alkaloid Levels in Dark Fire-Cured Tobacco.” 2018. Web. 02 Mar 2021.

Vancouver:

Brown MR. Agronomic Practices to Reduce Alkaloid Levels in Dark Fire-Cured Tobacco. [Internet] [Thesis]. University of Tennessee – Knoxville; 2018. [cited 2021 Mar 02]. Available from: https://trace.tennessee.edu/utk_gradthes/5352.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Brown MR. Agronomic Practices to Reduce Alkaloid Levels in Dark Fire-Cured Tobacco. [Thesis]. University of Tennessee – Knoxville; 2018. Available from: https://trace.tennessee.edu/utk_gradthes/5352

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas Christian University

16. Ochoa, Charles Israel,author. The total synthesis of hippadine and pratosine via an intramolecular de Mayo photocyclization.

Degree: 2018, Texas Christian University

URL: https://repository.tcu.edu/handle/116099117/22014

► Hippadine and pratosine are lycorine-type pharmacologically active Amaryllidaceae alkaloids. Various total syntheses of these natural products have been developed. However, most of these synthetic routes… (more)

Subjects/Keywords: Amaryllidaceae.; Alkaloids.; Photochemistry.

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APA (6^th Edition):

Ochoa, C. I. (2018). The total synthesis of hippadine and pratosine via an intramolecular de Mayo photocyclization. (Thesis). Texas Christian University. Retrieved from https://repository.tcu.edu/handle/116099117/22014

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ochoa, Charles Israel,author. “The total synthesis of hippadine and pratosine via an intramolecular de Mayo photocyclization.” 2018. Thesis, Texas Christian University. Accessed March 02, 2021. https://repository.tcu.edu/handle/116099117/22014.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ochoa, Charles Israel,author. “The total synthesis of hippadine and pratosine via an intramolecular de Mayo photocyclization.” 2018. Web. 02 Mar 2021.

Vancouver:

Ochoa CI. The total synthesis of hippadine and pratosine via an intramolecular de Mayo photocyclization. [Internet] [Thesis]. Texas Christian University; 2018. [cited 2021 Mar 02]. Available from: https://repository.tcu.edu/handle/116099117/22014.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ochoa CI. The total synthesis of hippadine and pratosine via an intramolecular de Mayo photocyclization. [Thesis]. Texas Christian University; 2018. Available from: https://repository.tcu.edu/handle/116099117/22014

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Texas A&M University

17. Reyes, Jeremy Chris Punzalan. ‘Bioinspired’ Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ‘Metabiosynthetic’ Studies.

Degree: PhD, Chemistry, 2013, Texas A&M University

URL: http://hdl.handle.net/1969.1/151657

► Numerous marine-derived pyrrole 2-aminoimidazole alkaloids (P-2-AIs), including the highly potent antitumor natural product agelastatin A, are presumed to be derived from the simple precursor oroidin… (more)

▼ Numerous marine-derived pyrrole 2-aminoimidazole alkaloids (P-2-AIs), including the highly potent antitumor natural product agelastatin A, are presumed to be derived from the simple precursor oroidin and related stuctures. The molecular complexity of P-2AIs, significant biological activities, as well as the interesting biosynthetic routes proposed for their origin has made this family of alkaloids the subject of numerous synthetic investigations. Herein, a bioinspired total synthesis of agelastatin A is described premised on the isolation of two other P-2AIs, keramadine and nagelamide J. Two biosynthetically relevant cyclizations rapidly convert a linear precursor, resembling an oxidized keramadine, to agelastatin A. A facile and highly diastereoselective C-ring formation via a 5-exo-trig cyclization or a Nazarov 4pi electrocyclization, proceeding through a deep-red colored N-acyliminium intermediate, constructs the three contiguous stereocenters of the cyclopentane core found in the agelastatins and nagelamide J. A possible templating effect was discovered in a silica gel-assisted reaction that enables the final B-ring closure. The described synthesis provided access to various agelastatin A derivatives leading to a bioactive biotin probe that is proving to be useful for cellular target identification. In an effort toward understanding the biosynthesis of P-2-AIs, a synthesis of^( 15)N-oroidin labeled oroidin was developed and pulse labeling and analysis by 1D ^(1)H-^(15)N HSQC NMR and FTMS experiments was validated as a direct method for measurement of ^(15)N incorporation into P2-AIs. Studies toward the synthesis of a ^(15)N-keramadine analog, which will be used to investigate the biosynthetic origin of agelastatin A, are also described. Advisors/Committee Members: Romo, Daniel (advisor), Singleton, Daniel A (committee member), Bergbreiter, David E (committee member), McKnight, Thomas D (committee member).

Subjects/Keywords: alkaloids; biomimetic synthesis; N-acyliminium; Nazarov cyclization; pyrrole-2-amino imidazole alkaloids; oroidin alkaloids; agelastatin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Reyes, J. C. P. (2013). ‘Bioinspired’ Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ‘Metabiosynthetic’ Studies. (Doctoral Dissertation). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/151657

Chicago Manual of Style (16^th Edition):

Reyes, Jeremy Chris Punzalan. “‘Bioinspired’ Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ‘Metabiosynthetic’ Studies.” 2013. Doctoral Dissertation, Texas A&M University. Accessed March 02, 2021. http://hdl.handle.net/1969.1/151657.

MLA Handbook (7^th Edition):

Reyes, Jeremy Chris Punzalan. “‘Bioinspired’ Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ‘Metabiosynthetic’ Studies.” 2013. Web. 02 Mar 2021.

Vancouver:

Reyes JCP. ‘Bioinspired’ Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ‘Metabiosynthetic’ Studies. [Internet] [Doctoral dissertation]. Texas A&M University; 2013. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1969.1/151657.

Council of Science Editors:

Reyes JCP. ‘Bioinspired’ Total Synthesis of Agelastatin A and Derivatives for Cellular Target Identification; Syntheses of ^(15)N-labeled Oroidin and Keramadine Analog for ‘Metabiosynthetic’ Studies. [Doctoral Dissertation]. Texas A&M University; 2013. Available from: http://hdl.handle.net/1969.1/151657

University of Tasmania

18. Gillard, John Walter. Structural and synthetic studies of alkaloids of the Proteaceae.

Degree: 1975, University of Tasmania

URL: https://eprints.utas.edu.au/19425/1/whole_GillardJohnWalter1976_thesis.pdf

► Following the discovery of the presence of alkaloids in an endemic Tasmanian Proteaceous species, Bellendena montana R.BR., a detailed phytochemical examination for alkaloids has been… (more)

Subjects/Keywords: Alkaloids; Proteaceae

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APA (6^th Edition):

Gillard, J. W. (1975). Structural and synthetic studies of alkaloids of the Proteaceae. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/19425/1/whole_GillardJohnWalter1976_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gillard, John Walter. “Structural and synthetic studies of alkaloids of the Proteaceae.” 1975. Thesis, University of Tasmania. Accessed March 02, 2021. https://eprints.utas.edu.au/19425/1/whole_GillardJohnWalter1976_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gillard, John Walter. “Structural and synthetic studies of alkaloids of the Proteaceae.” 1975. Web. 02 Mar 2021.

Vancouver:

Gillard JW. Structural and synthetic studies of alkaloids of the Proteaceae. [Internet] [Thesis]. University of Tasmania; 1975. [cited 2021 Mar 02]. Available from: https://eprints.utas.edu.au/19425/1/whole_GillardJohnWalter1976_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gillard JW. Structural and synthetic studies of alkaloids of the Proteaceae. [Thesis]. University of Tasmania; 1975. Available from: https://eprints.utas.edu.au/19425/1/whole_GillardJohnWalter1976_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

19. Douglas, Gordon Keith. Alkaloids of monimiaceous plants.

Degree: 1965, University of Tasmania

URL: https://eprints.utas.edu.au/19476/1/whole_DouglasGordonKeith1966_thesis.pdf

► Alkaloid-bearing plants of the Australian Monimiaceae have generally yielded alkaloids of the bisbenzylisoquinoline type. For this reason a brief outline of the chemistry of this… (more)

Subjects/Keywords: Alkaloids; Monimiaceae

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APA (6^th Edition):

Douglas, G. K. (1965). Alkaloids of monimiaceous plants. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/19476/1/whole_DouglasGordonKeith1966_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Douglas, Gordon Keith. “Alkaloids of monimiaceous plants.” 1965. Thesis, University of Tasmania. Accessed March 02, 2021. https://eprints.utas.edu.au/19476/1/whole_DouglasGordonKeith1966_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Douglas, Gordon Keith. “Alkaloids of monimiaceous plants.” 1965. Web. 02 Mar 2021.

Vancouver:

Douglas GK. Alkaloids of monimiaceous plants. [Internet] [Thesis]. University of Tasmania; 1965. [cited 2021 Mar 02]. Available from: https://eprints.utas.edu.au/19476/1/whole_DouglasGordonKeith1966_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Douglas GK. Alkaloids of monimiaceous plants. [Thesis]. University of Tasmania; 1965. Available from: https://eprints.utas.edu.au/19476/1/whole_DouglasGordonKeith1966_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

20. Gunawardana, YAGP. Structural studies on alkaloids from Peripentadenia MearsII and Hedycarya Angustifolia.

Degree: 1983, University of Tasmania

URL: https://eprints.utas.edu.au/19498/1/whole_GunawardanaYahampathArachchigeGeewanandaPerera1984_thesis.pdf

► A detailed phytochemical investigation of the alkaloids of two plant species: Peripentadenia mearsii (Elaeocarpaceae) and Hedycarya angustifblia (Monimiaceae) has been undertaken. P. mearsii was found… (more)

▼ A detailed phytochemical investigation of the alkaloids of two plant species: Peripentadenia mearsii (Elaeocarpaceae) and Hedycarya angustifblia (Monimiaceae) has been undertaken. P. mearsii was found to be a rather rich source of alkaloids: nearly thirty different alkaloids were detected in the bark and leaf extracts. A total of twenty bases and three non-alkaloidal compounds were isolated during this investigation. The structural elucidation of the major alkaloid, peripentadenine, was carried out by spectroscopic methods and by degradation. Detailed PMR and 13C NMR spectral assignments of peripentadenine and some of its twenty derivatives or degradation products are described. Approaches to the synthesis of EZaeocarpus alkaloids are reviewed. The structure of peripentadenine was finally confirmed by two different syntheses. Structures of three minor bases from the bark: dinorperipentadenine, peripentamine and dehydroperipentamine were also established. Dinorperipentadenine was synthesised, and the other two bases were converted to one of the Hofmann degradation products of peripentadenine. Tentative structures have been assigned for three other bases (PBXM2, PLM2 and PLM3) and partial structural analysis was carried out on two further bases (PBVMD and PLM4). The identities of the non-alkaloidal compounds isolated were established by spectroscopy as dimethylsulphone, methylgallate and 2-hydroxy-6-methylacetophenone. The remaining twelve bases were isolated in minute amounts, and only their mass spectra were recorded. Possible biosynthetic origins for Peripentadenia bases have been discussed. The presence of a three-carbon unit between two nitrogens was considered to be an interesting structural feature of these alkaloids and a list of compounds with similar features has been compiled. Nine alkaloids including four new compounds were isolated from Hedycaria angustifoZia. The new compounds include a benzylisoquinoline whose structure was established by X-ray crystallography (by Professor Allan H. White, University of Western Australia), a tetrahydrobenzylisoquinoline, a phenanthrene and a dehydraporphine. The known compounds isolated are all aporphines. Two non-alkaloidal compounds, 2,3-camphanediol and eudesmol, were also isolated from the same plant. The isolation of the alkaloids of Macademia integrifolia was also attempted but a successful method could not be developed.

Subjects/Keywords: Alkaloids; Peripentadenine

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APA (6^th Edition):

Gunawardana, Y. (1983). Structural studies on alkaloids from Peripentadenia MearsII and Hedycarya Angustifolia. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/19498/1/whole_GunawardanaYahampathArachchigeGeewanandaPerera1984_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gunawardana, YAGP. “Structural studies on alkaloids from Peripentadenia MearsII and Hedycarya Angustifolia.” 1983. Thesis, University of Tasmania. Accessed March 02, 2021. https://eprints.utas.edu.au/19498/1/whole_GunawardanaYahampathArachchigeGeewanandaPerera1984_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gunawardana, YAGP. “Structural studies on alkaloids from Peripentadenia MearsII and Hedycarya Angustifolia.” 1983. Web. 02 Mar 2021.

Vancouver:

Gunawardana Y. Structural studies on alkaloids from Peripentadenia MearsII and Hedycarya Angustifolia. [Internet] [Thesis]. University of Tasmania; 1983. [cited 2021 Mar 02]. Available from: https://eprints.utas.edu.au/19498/1/whole_GunawardanaYahampathArachchigeGeewanandaPerera1984_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gunawardana Y. Structural studies on alkaloids from Peripentadenia MearsII and Hedycarya Angustifolia. [Thesis]. University of Tasmania; 1983. Available from: https://eprints.utas.edu.au/19498/1/whole_GunawardanaYahampathArachchigeGeewanandaPerera1984_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

21. Harvest, TM. Laticifers and Latex in Papaver somniferum L.; Capacity, development and translocation.

Degree: 2011, University of Tasmania

URL: https://eprints.utas.edu.au/12463/7/TMAH_PhD_2011_full_thesis_ex_pub_mat.pdf ; https://eprints.utas.edu.au/12463/3/TMAH_PhD_2011_full_thesis.pdf

► The opium poppy, Papaver somniferum L., is a pharmaceutically important species that is of commercial significance in the state of Tasmania, Australia. Poppies are grown… (more)

▼ The opium poppy, Papaver somniferum L., is a pharmaceutically important species that is of commercial significance in the state of Tasmania, Australia. Poppies are grown for seed and notably for their alkaloids, including morphine, codeine and thebaine. Alkaloids accumulate in the capsule during plant development, sequestered to vesicles within the latex of the reticulated network of laticifer cells. Laticifers, as the repository for alkaloids in poppies, are potentially an important component in the yield of alkaloids, and there are aspects of these cells that have not been fully investigated. The studies herein examined the volumetric capacity of capsule laticifers; the allocation of biomass to poppy capsules; and the capability of laticifers to deliver alkaloids to the capsule through the bulk movement of latex. Capsule laticifer capacity is of relevance in the cropping system used in Australia, where capsules are not lanced and remain intact until harvesting, which occurs after plant senescence. Variations in the volumetric capacity may represent a component of the alkaloid yield from capsules, and the first investigation assessed the quantity and variability of this parameter in field grown poppies. The latex volume was calculated for capsules that were harvested at one week, and at two weeks after flowering. It was demonstrated that the volume of laticifers per unit area of tissue was established early in capsule development (before the first week of flowering) and did not increase thereafter, yet capsule morphine content continued to rise. The capacity determined at either stage did not predict the end-yield of morphine, but there was a positive linear relationship with capsule mass, and capsule mass was the most important factor in capsule morphine yield. It was concluded that the volumetric capacity of capsule laticifers was established early in capsule development, and therefore has limited utility as a component that may be manipulated to increase capsule alkaloid yields. Factors influencing capsule mass were further investigated. The within-plant allocation of biomass to capsules was investigated in a field study of P. somniferum plant morphology. Greater than 80% of the capsule biomass was allocated to the upper three capsules, with the senescence of reproductive structures more prevalent on lower branches. The findings indicated that in the development of this commercial line of poppies there was sequential regulation of the sinks (fruit), and that the majority of reproductive biomass was allocated to the early developing capsules in terms of both fruit and seed. An argument was presented to suggest that developmental processes and within-plant resource limitation may influence the allocation of biomass to reproductive structures in poppies. Due to the complex interplay of sink strength and feedback mechanisms, and with so little modelling of within-plant biomass allocation in poppies, additional studies were suggested. The capability of laticifers to deliver alkaloids…

Subjects/Keywords: Laticifers; latex; poppy; alkaloids; morphine

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APA (6^th Edition):

Harvest, T. (2011). Laticifers and Latex in Papaver somniferum L.; Capacity, development and translocation. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/12463/7/TMAH_PhD_2011_full_thesis_ex_pub_mat.pdf ; https://eprints.utas.edu.au/12463/3/TMAH_PhD_2011_full_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Harvest, TM. “Laticifers and Latex in Papaver somniferum L.; Capacity, development and translocation.” 2011. Thesis, University of Tasmania. Accessed March 02, 2021. https://eprints.utas.edu.au/12463/7/TMAH_PhD_2011_full_thesis_ex_pub_mat.pdf ; https://eprints.utas.edu.au/12463/3/TMAH_PhD_2011_full_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Harvest, TM. “Laticifers and Latex in Papaver somniferum L.; Capacity, development and translocation.” 2011. Web. 02 Mar 2021.

Vancouver:

Harvest T. Laticifers and Latex in Papaver somniferum L.; Capacity, development and translocation. [Internet] [Thesis]. University of Tasmania; 2011. [cited 2021 Mar 02]. Available from: https://eprints.utas.edu.au/12463/7/TMAH_PhD_2011_full_thesis_ex_pub_mat.pdf ; https://eprints.utas.edu.au/12463/3/TMAH_PhD_2011_full_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Harvest T. Laticifers and Latex in Papaver somniferum L.; Capacity, development and translocation. [Thesis]. University of Tasmania; 2011. Available from: https://eprints.utas.edu.au/12463/7/TMAH_PhD_2011_full_thesis_ex_pub_mat.pdf ; https://eprints.utas.edu.au/12463/3/TMAH_PhD_2011_full_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Vanderbilt University

22. Hahn, Kristopher Neil. A general approach to medium ring azabicycles, total synthesis of cremastrine, and total synthesis of grandisine D.

Degree: MS, Chemistry, 2012, Vanderbilt University

URL: http://hdl.handle.net/1803/14395

► The azabicyclic ring system is a common structural subunit present in numerous alkaloid natural products and serves as an important scaffold in biologically active and… (more)

Subjects/Keywords: azabicycles; cremastrine; grandisine D; alkaloids

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APA (6^th Edition):

Hahn, K. N. (2012). A general approach to medium ring azabicycles, total synthesis of cremastrine, and total synthesis of grandisine D. (Thesis). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/14395

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hahn, Kristopher Neil. “A general approach to medium ring azabicycles, total synthesis of cremastrine, and total synthesis of grandisine D.” 2012. Thesis, Vanderbilt University. Accessed March 02, 2021. http://hdl.handle.net/1803/14395.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hahn, Kristopher Neil. “A general approach to medium ring azabicycles, total synthesis of cremastrine, and total synthesis of grandisine D.” 2012. Web. 02 Mar 2021.

Vancouver:

Hahn KN. A general approach to medium ring azabicycles, total synthesis of cremastrine, and total synthesis of grandisine D. [Internet] [Thesis]. Vanderbilt University; 2012. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1803/14395.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hahn KN. A general approach to medium ring azabicycles, total synthesis of cremastrine, and total synthesis of grandisine D. [Thesis]. Vanderbilt University; 2012. Available from: http://hdl.handle.net/1803/14395

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

23. Mason, Jeremy David. Total Synthesis of (±)-Alstoscholarisines A-E.

Degree: 2018, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/15645jdm505

► Total syntheses of the biologically active monoterpenoid indole alkaloids (±)-alstoscholarisines A-E (1-5) have been completed in twelve to fourteen steps. The approach commenced with a… (more)

Subjects/Keywords: Indole Alkaloids; Organic Synthesis

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APA (6^th Edition):

Mason, J. D. (2018). Total Synthesis of (±)-Alstoscholarisines A-E. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/15645jdm505

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mason, Jeremy David. “Total Synthesis of (±)-Alstoscholarisines A-E.” 2018. Thesis, Penn State University. Accessed March 02, 2021. https://submit-etda.libraries.psu.edu/catalog/15645jdm505.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mason, Jeremy David. “Total Synthesis of (±)-Alstoscholarisines A-E.” 2018. Web. 02 Mar 2021.

Vancouver:

Mason JD. Total Synthesis of (±)-Alstoscholarisines A-E. [Internet] [Thesis]. Penn State University; 2018. [cited 2021 Mar 02]. Available from: https://submit-etda.libraries.psu.edu/catalog/15645jdm505.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mason JD. Total Synthesis of (±)-Alstoscholarisines A-E. [Thesis]. Penn State University; 2018. Available from: https://submit-etda.libraries.psu.edu/catalog/15645jdm505

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Adelaide

24. Tippett, James Morton. Synthesis of phthalideisoquinoline alkaloids and of other antagonists of γ-aminobutyric acid.

Degree: 1977, University of Adelaide

URL: http://hdl.handle.net/2440/115379

Subjects/Keywords: Alkaloids; Isoquinoline

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APA (6^th Edition):

Tippett, J. M. (1977). Synthesis of phthalideisoquinoline alkaloids and of other antagonists of γ-aminobutyric acid. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/115379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tippett, James Morton. “Synthesis of phthalideisoquinoline alkaloids and of other antagonists of γ-aminobutyric acid.” 1977. Thesis, University of Adelaide. Accessed March 02, 2021. http://hdl.handle.net/2440/115379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tippett, James Morton. “Synthesis of phthalideisoquinoline alkaloids and of other antagonists of γ-aminobutyric acid.” 1977. Web. 02 Mar 2021.

Vancouver:

Tippett JM. Synthesis of phthalideisoquinoline alkaloids and of other antagonists of γ-aminobutyric acid. [Internet] [Thesis]. University of Adelaide; 1977. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2440/115379.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tippett JM. Synthesis of phthalideisoquinoline alkaloids and of other antagonists of γ-aminobutyric acid. [Thesis]. University of Adelaide; 1977. Available from: http://hdl.handle.net/2440/115379

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Oregon State University

25. Lee, Nadine Chauyi. Synthetic studies on necic acids of pyrrolizidine alkaloids.

Degree: PhD, Chemistry, 1998, Oregon State University

URL: http://hdl.handle.net/1957/34132

Subjects/Keywords: Alkaloids – Synthesis

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APA (6^th Edition):

Lee, N. C. (1998). Synthetic studies on necic acids of pyrrolizidine alkaloids. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/34132

Chicago Manual of Style (16^th Edition):

Lee, Nadine Chauyi. “Synthetic studies on necic acids of pyrrolizidine alkaloids.” 1998. Doctoral Dissertation, Oregon State University. Accessed March 02, 2021. http://hdl.handle.net/1957/34132.

MLA Handbook (7^th Edition):

Lee, Nadine Chauyi. “Synthetic studies on necic acids of pyrrolizidine alkaloids.” 1998. Web. 02 Mar 2021.

Vancouver:

Lee NC. Synthetic studies on necic acids of pyrrolizidine alkaloids. [Internet] [Doctoral dissertation]. Oregon State University; 1998. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1957/34132.

Council of Science Editors:

Lee NC. Synthetic studies on necic acids of pyrrolizidine alkaloids. [Doctoral Dissertation]. Oregon State University; 1998. Available from: http://hdl.handle.net/1957/34132

Oregon State University

26. Shin, Hyunik. An approach toward the synthesis of euonyminol and cathedulin K- 19.

Degree: PhD, Chemistry, 1994, Oregon State University

URL: http://hdl.handle.net/1957/36359

► A synthetic approach toward the two major fragments of cathedulin K-19, euonyminol (4) and dimethyl cathate (69), was investigated. Synthesis of dimethyl cathate was accomplished… (more)

Subjects/Keywords: Alkaloids – Synthesis

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APA (6^th Edition):

Shin, H. (1994). An approach toward the synthesis of euonyminol and cathedulin K- 19. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/36359

Chicago Manual of Style (16^th Edition):

Shin, Hyunik. “An approach toward the synthesis of euonyminol and cathedulin K- 19.” 1994. Doctoral Dissertation, Oregon State University. Accessed March 02, 2021. http://hdl.handle.net/1957/36359.

MLA Handbook (7^th Edition):

Shin, Hyunik. “An approach toward the synthesis of euonyminol and cathedulin K- 19.” 1994. Web. 02 Mar 2021.

Vancouver:

Shin H. An approach toward the synthesis of euonyminol and cathedulin K- 19. [Internet] [Doctoral dissertation]. Oregon State University; 1994. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1957/36359.

Council of Science Editors:

Shin H. An approach toward the synthesis of euonyminol and cathedulin K- 19. [Doctoral Dissertation]. Oregon State University; 1994. Available from: http://hdl.handle.net/1957/36359

Oregon State University

27. Swanson, Hollie I. Effects of the anticarcinogen indole-3-carbinol on Xenobiotic metabolizing enzymes in rainbow trout.

Degree: MS, Food Science and Technology, 1988, Oregon State University

URL: http://hdl.handle.net/1957/27196

► Indole-3-carbinol (I3C) inhibits chemically induced tumor formation in rodents and rainbow trout. This study examines the effect of I3C and its analog, indole-3-acetonitrile (I3N) on… (more)

▼ Indole-3-carbinol (I3C) inhibits chemically induced tumor formation in rodents and rainbow trout. This study examines the effect of I3C and its analog, indole-3-acetonitrile (I3N) on xenobiotic-metabolizing enzyme systems. The modulation of these enzyme systems have been shown to have significant effects on the interaction of chemical carcinogens and cellular constituents. Rainbow trout were fed 500, 1000 and 2000 ppm dietary levels of I3C and 50, 500 and 1000 ppm dietary levels of I3N for 8 days. β-napthoflavone (BNF), which is also an effective anticarcinogen in the trout, was fed at a 500 ppm dietary level and was used as a positive LM4b (a cytochrome P-450 isozyme) inducing control. Enzyme activities assayed were: ethoxyresorufin-O-deethylase (EROD), ethoxycoumarin-O-deethylase (ECOD), glutathione S-transferase (GST), and uridine diphosphoglucuronosyl transferase (UDPGT). Total cytochrome P-450 content was determined spectrophotometrically by the CO reduced method. The specific P-450 isozymes, LM2 and LM4b, were detected quantitatively using the western blot method. The BNF diet induced EROD and ECOD activities by an average of 17 fold and 5.5 fold, respectively. Total P-450 content was increased 2-fold; the P-450 isozyme LM4b was induced more than 5-fold, but LM2 content remained unchanged. This diet increased UDPGT activity 1.5-2-fold, but GST activity was not induced by dietary BNF. Neither I3C nor I3N induced the activity levels of the enzymes assayed at any administered dietary levels, which have previously shown to inhibit tumor formation and reduce formation of carcinogen-DNA adducts. Thus, the anticarcinogenic mechanism of I3C may proceed in trout by mechanisms other than enzyme induction. Further experiments on the effect of I3C and I3C acid condensation products (RXN) on in vitro AFB1-DNA binding resulted in a 40% and 48% inhibition of AFB1-DNA binding by I3C and RXN, respectively. Additions of RXN at levels much lower than those estimated to exist in vivo in hepatic tissue resulted in a significant reduction in AFB1-DNA formation suggesting that even small levels of RXN offers protection against the genotoxic effect of AFB1. However, in vitro additions of neither I3C nor RXN had an effect on DNA binding using AFBI-CI₂, an aflatoxin analog that does not require enzymatic activation. These results suggest that the primary mechanism for I3C inhibition of AFB1 induced carcinogenesis may proceed by inhibiton of formation of the ultimate electrophile, i.e. by reversible inhibition of cytochrome P-450. Advisors/Committee Members: Bailey, George S. (advisor).

Subjects/Keywords: Indole alkaloids

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Swanson, H. I. (1988). Effects of the anticarcinogen indole-3-carbinol on Xenobiotic metabolizing enzymes in rainbow trout. (Masters Thesis). Oregon State University. Retrieved from http://hdl.handle.net/1957/27196

Chicago Manual of Style (16^th Edition):

Swanson, Hollie I. “Effects of the anticarcinogen indole-3-carbinol on Xenobiotic metabolizing enzymes in rainbow trout.” 1988. Masters Thesis, Oregon State University. Accessed March 02, 2021. http://hdl.handle.net/1957/27196.

MLA Handbook (7^th Edition):

Swanson, Hollie I. “Effects of the anticarcinogen indole-3-carbinol on Xenobiotic metabolizing enzymes in rainbow trout.” 1988. Web. 02 Mar 2021.

Vancouver:

Swanson HI. Effects of the anticarcinogen indole-3-carbinol on Xenobiotic metabolizing enzymes in rainbow trout. [Internet] [Masters thesis]. Oregon State University; 1988. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/1957/27196.

Council of Science Editors:

Swanson HI. Effects of the anticarcinogen indole-3-carbinol on Xenobiotic metabolizing enzymes in rainbow trout. [Masters Thesis]. Oregon State University; 1988. Available from: http://hdl.handle.net/1957/27196

Colorado State University

28. Tembrock, Luke Raymond. Study of plant domestication and evolution through the taxonomic revision of wild North American Humulus, a phytochemical assay for stimulant alkaloids in Celastraceae, and a phylogeographic analysis of Catha edulis in areas of historic cultivation, A.

Degree: PhD, Biology, 2015, Colorado State University

URL: http://hdl.handle.net/10217/170432

► The cultivation of plant species is essential to the survival of humans. The process of artificial selection that is used to modify wild individuals into… (more)

▼ The cultivation of plant species is essential to the survival of humans. The process of artificial selection that is used to modify wild individuals into improved cultivars results in genetic and morphological changes from wild progenitors. In order to understand the evolutionary patterns and processes involved with artificial selection both wild and cultivated populations must be thoroughly studied. Numerous methods are used to study the process of evolution under cultivation such as biology, chemistry, geography, history, linguistics and archeology. The understanding of evolution in a crop species is essential in current improvement programs to increase yield for a given crop. I employed methods from the fields of taxonomy, analytical chemistry and phylogeography to study the process of evolution in cultivated plant species and/or their wild relatives. From a review of taxonomic, genetic, and phytochemical literature, as well as examination of morphological features I revised the wild North American Humulus (Cannabacae) in a manner that properly delimits the diversity found among the North American species. Using GC–MS and a forensics based derivatization method I assayed for the stimulant alkaloids cathinone, cathine, and similar compounds across the Celastraceae plant family. It was found that that qat (Catha edulis) was the only species of those tested that biosynthesized cathinone and cathine. Using phylogeographic and population genetic techniques I inferred three wild regional origins, hybridization and numerous translocations out of the centers of origin for cultivated qat. From farmer interviews I examined what properties, genotype, phenotype, and/or geography explained the naming convention for qat cultivars among qat farmers. The character of stem color was found to highly plastic and thus genotype was not significantly correlated with the naming convention. Geographic patterns were confirmed for several cultivar names suggesting that anthropogenic factors are important in the naming conventions used among qat farmers. These four separate studies provide findings that not only clarify our understanding of evolutionary patterns among wild and cultivated species but provide a framework for breeding, conservation and forensic applications in the future. Advisors/Committee Members: Simmons, Mark P. (advisor), Angert, Amy L. (committee member), Richards, Christopher M. (committee member), Ward, Sarah M. (committee member).

Subjects/Keywords: alkaloids; phylogeography; SSR; Catha; Humulus

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APA (6^th Edition):

Tembrock, L. R. (2015). Study of plant domestication and evolution through the taxonomic revision of wild North American Humulus, a phytochemical assay for stimulant alkaloids in Celastraceae, and a phylogeographic analysis of Catha edulis in areas of historic cultivation, A. (Doctoral Dissertation). Colorado State University. Retrieved from http://hdl.handle.net/10217/170432

Chicago Manual of Style (16^th Edition):

Tembrock, Luke Raymond. “Study of plant domestication and evolution through the taxonomic revision of wild North American Humulus, a phytochemical assay for stimulant alkaloids in Celastraceae, and a phylogeographic analysis of Catha edulis in areas of historic cultivation, A.” 2015. Doctoral Dissertation, Colorado State University. Accessed March 02, 2021. http://hdl.handle.net/10217/170432.

MLA Handbook (7^th Edition):

Tembrock, Luke Raymond. “Study of plant domestication and evolution through the taxonomic revision of wild North American Humulus, a phytochemical assay for stimulant alkaloids in Celastraceae, and a phylogeographic analysis of Catha edulis in areas of historic cultivation, A.” 2015. Web. 02 Mar 2021.

Vancouver:

Tembrock LR. Study of plant domestication and evolution through the taxonomic revision of wild North American Humulus, a phytochemical assay for stimulant alkaloids in Celastraceae, and a phylogeographic analysis of Catha edulis in areas of historic cultivation, A. [Internet] [Doctoral dissertation]. Colorado State University; 2015. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/10217/170432.

Council of Science Editors:

Tembrock LR. Study of plant domestication and evolution through the taxonomic revision of wild North American Humulus, a phytochemical assay for stimulant alkaloids in Celastraceae, and a phylogeographic analysis of Catha edulis in areas of historic cultivation, A. [Doctoral Dissertation]. Colorado State University; 2015. Available from: http://hdl.handle.net/10217/170432

University of Adelaide

29. Tran Viet Hung. The synthesis of aromatic and aza analogues of phthalideisoquinoline / by Tran Viet Hung.

Degree: 1981, University of Adelaide

URL: http://hdl.handle.net/2440/21337

Subjects/Keywords: Isoquinoline.; Alkaloids.

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APA (6^th Edition):

Hung, T. V. (1981). The synthesis of aromatic and aza analogues of phthalideisoquinoline / by Tran Viet Hung. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/21337

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hung, Tran Viet. “The synthesis of aromatic and aza analogues of phthalideisoquinoline / by Tran Viet Hung.” 1981. Thesis, University of Adelaide. Accessed March 02, 2021. http://hdl.handle.net/2440/21337.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hung, Tran Viet. “The synthesis of aromatic and aza analogues of phthalideisoquinoline / by Tran Viet Hung.” 1981. Web. 02 Mar 2021.

Vancouver:

Hung TV. The synthesis of aromatic and aza analogues of phthalideisoquinoline / by Tran Viet Hung. [Internet] [Thesis]. University of Adelaide; 1981. [cited 2021 Mar 02]. Available from: http://hdl.handle.net/2440/21337.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hung TV. The synthesis of aromatic and aza analogues of phthalideisoquinoline / by Tran Viet Hung. [Thesis]. University of Adelaide; 1981. Available from: http://hdl.handle.net/2440/21337

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Hong Kong University of Science and Technology

30. Zhou, Shiqiang CHEM. Collective total syntheses of protoberberine-chilenamine alkaloids and eburnamine-vincamine-tacamine indole alkaloids.

Degree: 2017, Hong Kong University of Science and Technology

URL: http://repository.ust.hk/ir/Record/1783.1-100443 ; https://doi.org/10.14711/thesis-991012564469303412 ; http://repository.ust.hk/ir/bitstream/1783.1-100443/1/th_redirect.html

► This thesis consists of four chapters which describe the collective total syntheses of natural products and development of asymmetric synthetic strategy. Chapter one is focused… (more)

▼ This thesis consists of four chapters which describe the collective total syntheses of natural products and development of asymmetric synthetic strategy. Chapter one is focused on the collective total syntheses of Protoberberine alkaloids; Chapter two presents the first asymmetric total syntheses of 13-Methyltetrahydroprotoberbeines; Chapter three describes the total synthesis Eburnamine-Vincamine-Tacamine alkaloids and progress on the asymmetric alkynylation of carboline iminium ion; Chapter four is summary and the appendix containing NMR spectra and HPLC data. Chapter one described a general and concise strategy for the collective total syntheses of more than 50 protoberberine alkaloids and five aporhoeadane alkaloids with 4-8 steps. Protoberberine alkaloids are a pharmacologically important class of isoquinoline alkaloids for their broad and potent biological activities. However, all prior strategies have been tailored for a single class of protoberberine alkaloids with focus on semisynthesis and lack of generality and flexibility. Our strategy is hinged on a newly established CuI-catalyzed redox-A³ reaction (alkyne, aldehyde and amine) and the subsequent palladium-catalyzed reductive carbocyclization to prepare the key tetracyclic intermediate, which was elaborated within 5 steps to five types of protoberberine alkaloid natural products. (i) a subsequent PtO₂ or Pd/C hydrogenation of tetracyclic intermediate furnished twelve 13-methyltetrahydroprotoberberines in three steps with 44-65% overall yield; (ii) after a one-pot Rh-catalyzed olefin isomerization/aromatization process of the key tetracyclic intermediate, fourteen 13-methylprotoberberines and analogues were obtained with 25-48% overall yield; (iii) Ru-catalyzed oxidation of the tetracyclic intermediate followed by Rh-catalyzed reductive decarbonylation produced eight 8-oxyprotoberberines in four steps with overall 16-36% yield; (iv) reduction or oxidation of the eight 8-oxyprotoberberines enabled us to accomplish the collective synthesis of the corresponding tetrahydroprotoberberines and protoberberines. Finally, Shamma translactamization of the prechilenine intermediate generated by oxidation of the tetracyclic intermediate gave the alkaloid chilenine, which was elaborated using the reported methods to four aporhoeadane natural products within five steps. Notably, this strategy represents the most efficient and shortest synthetic route to the 13-methylprotoberberines, most of which were synthesized for the first time. Chapter two described the first asymmetric collective total syntheses of twelve 13-methyltetrahydroprotoberberines. The importance of C13 substitution to the biological activity of protoberberine alkaloids has been well recognized in the medicinal chemistry community; while their synthetic methods, in particular asymmetric synthesis, are rather underdeveloped. In continuation of our interest and previous work (Chapter one), we embarked on the development of asymmetric synthesis by exploiting the key redox-A³…

Subjects/Keywords: Alkaloids ; Synthesis ; Chemical reactions

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APA (6^th Edition):

Zhou, S. C. (2017). Collective total syntheses of protoberberine-chilenamine alkaloids and eburnamine-vincamine-tacamine indole alkaloids. (Thesis). Hong Kong University of Science and Technology. Retrieved from http://repository.ust.hk/ir/Record/1783.1-100443 ; https://doi.org/10.14711/thesis-991012564469303412 ; http://repository.ust.hk/ir/bitstream/1783.1-100443/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zhou, Shiqiang CHEM. “Collective total syntheses of protoberberine-chilenamine alkaloids and eburnamine-vincamine-tacamine indole alkaloids.” 2017. Thesis, Hong Kong University of Science and Technology. Accessed March 02, 2021. http://repository.ust.hk/ir/Record/1783.1-100443 ; https://doi.org/10.14711/thesis-991012564469303412 ; http://repository.ust.hk/ir/bitstream/1783.1-100443/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zhou, Shiqiang CHEM. “Collective total syntheses of protoberberine-chilenamine alkaloids and eburnamine-vincamine-tacamine indole alkaloids.” 2017. Web. 02 Mar 2021.

Vancouver:

Zhou SC. Collective total syntheses of protoberberine-chilenamine alkaloids and eburnamine-vincamine-tacamine indole alkaloids. [Internet] [Thesis]. Hong Kong University of Science and Technology; 2017. [cited 2021 Mar 02]. Available from: http://repository.ust.hk/ir/Record/1783.1-100443 ; https://doi.org/10.14711/thesis-991012564469303412 ; http://repository.ust.hk/ir/bitstream/1783.1-100443/1/th_redirect.html.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zhou SC. Collective total syntheses of protoberberine-chilenamine alkaloids and eburnamine-vincamine-tacamine indole alkaloids. [Thesis]. Hong Kong University of Science and Technology; 2017. Available from: http://repository.ust.hk/ir/Record/1783.1-100443 ; https://doi.org/10.14711/thesis-991012564469303412 ; http://repository.ust.hk/ir/bitstream/1783.1-100443/1/th_redirect.html

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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Open Access Theses and Dissertations