subject:(Algorithme g n tique)

1. Bedrat, Amina. G4-Hunter : un nouvel algorithme pour la prédiction des G-quadruplexes : G4-Hunter : a new algorithm for G-quadruplexes prediction’s.

Degree: Docteur es, Bioinformatique, 2015, Bordeaux

URL: http://www.theses.fr/2015BORD0197

►

Des séquences compatibles avec la formation de G4 sont présentes au niveau de certaines régions clés du génome telles que les extrémités des chromosomes, mais… (more)

▼

Des séquences compatibles avec la formation de G4 sont présentes au niveau de certaines régions clés du génome telles que les extrémités des chromosomes, mais également les régions de commutation de classe des immunoglobulines, les promoteurs de certains gènes dont des oncogènes et des séquences transcrites. Plus de 370 000 cibles potentielles ont été prédites lors des analyses bioinformatiques du génome humain. Cependant, ces prédictions ne sont pas exhaustives étant limitées par la formulation des algorithmes de prédiction utilisés. En effet, les séquences recherchées suivent la formule consensus suivante G3+N(1−7)G3+N(1−7)G3+N(1−7)G3+. Ainsi, en apportant plus de souplesse dans la description du quadruplex nous pourrons identifier et localiser plus de cibles potentielles. C’est pourquoi, nous proposons un nouvel algorithme G4-Hunter qui permettra l’identification la plus exhaustive possible de séquences cibles en prenant en compte la totalité de la région et non plus uniquement la cible potentielle. Par ailleurs, une étude expérimentale à grande échelle (sur une centaine de séquences cibles) a été menée afin de valider et tester la robustesse de G4-Hunter. A l’aide de ce nouvel outil, nous avons pu identifier de nouvelles séquences cibles non identifiées par les approches déjà existantes au sein des génomes humain, HIV et Dictyostelium discoideum.

Biologically relevant G4 DNA structures are formed throughout the genome including immunoglobulin switch regions, promoter sequences and telomeric repeats. They can arise when single-stranded G-rich DNA or RNA sequences are exposed during replication, transcription or recombination. Computational analysis using predictive algorithms suggests that the human genome contains approximately 370 000 potential G4-forming sequences. These predictions are generally limited to the standard G3+N(1−7)G3+N(1−7)G3+N(1−7)G3+ description. However, many stable G4s defy this description and escape this consensus; this is the reason why broadening this description should allow the prediction of more G4 loci. We propose an objective score function, G4- hunter, which predicts G4 folding propensity from a linear nucleic acid sequence. The new method focus on guanines clusters and GC asymmetry, taking into account the whole genomic region rather than individual quadruplexes sequences. In parallel with this computational technique, a large scale in vitro experimental work has also been developed to validate the performance of our algorithm in silico on one hundred of different sequences. G4- hunter exhibits unprecedented accuracy and sensitivity and leads us to reevaluate significantly the number of G4-prone sequences in the human genome. G4-hunter also allowed us to predict potential G4 sequences in HIV and Dictyostelium discoideum, which could not be identified by previous computational methods.

Advisors/Committee Members: Mergny, Jean-Louis (thesis director).

Subjects/Keywords: Bioinformatique; G-quadruplex; ADN; Mitochondrie; Algorithme; Bioinformatic; G-quadruplex; DNA; Mitochondria; Algorithm

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Bedrat, A. (2015). G4-Hunter : un nouvel algorithme pour la prédiction des G-quadruplexes : G4-Hunter : a new algorithm for G-quadruplexes prediction’s. (Doctoral Dissertation). Bordeaux. Retrieved from http://www.theses.fr/2015BORD0197

Chicago Manual of Style (16^th Edition):

Bedrat, Amina. “G4-Hunter : un nouvel algorithme pour la prédiction des G-quadruplexes : G4-Hunter : a new algorithm for G-quadruplexes prediction’s.” 2015. Doctoral Dissertation, Bordeaux. Accessed January 22, 2020. http://www.theses.fr/2015BORD0197.

MLA Handbook (7^th Edition):

Bedrat, Amina. “G4-Hunter : un nouvel algorithme pour la prédiction des G-quadruplexes : G4-Hunter : a new algorithm for G-quadruplexes prediction’s.” 2015. Web. 22 Jan 2020.

Vancouver:

Bedrat A. G4-Hunter : un nouvel algorithme pour la prédiction des G-quadruplexes : G4-Hunter : a new algorithm for G-quadruplexes prediction’s. [Internet] [Doctoral dissertation]. Bordeaux; 2015. [cited 2020 Jan 22]. Available from: http://www.theses.fr/2015BORD0197.

Council of Science Editors:

Bedrat A. G4-Hunter : un nouvel algorithme pour la prédiction des G-quadruplexes : G4-Hunter : a new algorithm for G-quadruplexes prediction’s. [Doctoral Dissertation]. Bordeaux; 2015. Available from: http://www.theses.fr/2015BORD0197

2. Boulakirba, Sonia. Étude des mécanismes moléculaires qui contrôlent l’interaction entre EFA6 et ses partenaires : Molecular mechanisms that control the interaction between EFA6 and its partners.

Degree: Docteur es, Interactions moléculaires et cellulaires, 2015, Nice

URL: http://www.theses.fr/2015NICE4081

►

La petite protéine G Arf6 et son facteur d'échange EFA6 sont impliquées dans de nombreux processus cellulaires tels que le remodelage du cytosquelette d’actine, le… (more)

▼

La petite protéine G Arf6 et son facteur d'échange EFA6 sont impliquées dans de nombreux processus cellulaires tels que le remodelage du cytosquelette d’actine, le transport vésiculaire et mise en place de la polarité épithéliale. Elles jouent également un rôle dans la voie d'endocytose dépendante de la clathrine. Ce travail de thèse nous a permis d’identifier différents mécanismes régulant l’interaction d’EFA6 avec ses différents partenaires. Nous avons pu mettre en évidence une interaction directe entre le domaine N-BAR de l’endophiline et le domaine Sec7 d’EFA6. Nous avons démontré que la courbure membranaire était un facteur régulant cette interaction. EFA6 est capable d’interagir et de recruter l’endophiline sur une membrane lipidique plane alors qu’en présence de vésicules courbées le complexe protéique ne se forme pas. Nous observons également que l’endophiline stimule l’activité d’échange nucléotidique d’EFA6 sur Arf6. Dans un second temps nous avons démontré, dans une étude menée par le Dr Cherfils, que l’activité catalytique d’EFA6 était régulée par une boucle de rétrocontrôle négatif exercée spécifiquement par la protéine Arf6-GTP. Celle-ci induit une diminution de l’activité d’échange d’EFA6 probablement grâce à sa capacité à interagir avec le domaine PH-C-terminal d’EFA6. Enfin, nous avons mis en évidence un repli intramoléculaire entre le domaine C-terminal et le domaine PH d’EFA6 qui semble contrôler l’interaction de cette extrémité C-terminale avec différents partenaires dont la β-arrestine et de façon surprenante la protéine Arf6 dans sa forme inactive.

The small G protein Arf6 and its exchange factor EFA6 control numerous cellular processes such as actin cytoskeleton remodeling, vesicular transport and apico-basal cell polarity. They are also involved in clathrin-dependent endocytosis. In this work we identify different mechanisms by which EFA6 interaction with its various partners is regulated. We have highlighted a direct interaction between the N-BAR domain of endophilin and the Sec7 domain of EFA6. We demonstrated that this interaction is regulated by the membrane curvature. EFA6 interacts and recruits endophilin on a flat lipid membrane whereas the protein complex does not occur in the presence of curved vesicules. We showed that endophilin stimulates the nucleotidic exchange activity of EFA6 on Arf6. Next we demonstrated that the catalytic activity of EFA6 is regulated by a negative feedback loop specifically mediated by the Arf6-GTP. We observed in the presence of Arf6-GTP a decrease of EFA6 catalytic activity and we showed that this effect was due to an interaction between Arf6-GTP and PH-C-terminal domain of EFA6. Finally we demonstrated an intramolecular folding between the C-terminal domain and the PH domain of EFA6 that controls the interaction of the C-terminus domain with various partners including β-arrestin and surprisingly the inactive GDP form of Arf6.

Advisors/Committee Members: Franco, Michel (thesis director).

Subjects/Keywords: Petite protéine G; Facteur d'échange; EFA6; Endocytose; Domaine N-BAR; Small G protein; Exchange factor; EFA6; Endocytosis; N-BAR domain

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Boulakirba, S. (2015). Étude des mécanismes moléculaires qui contrôlent l’interaction entre EFA6 et ses partenaires : Molecular mechanisms that control the interaction between EFA6 and its partners. (Doctoral Dissertation). Nice. Retrieved from http://www.theses.fr/2015NICE4081

Chicago Manual of Style (16^th Edition):

Boulakirba, Sonia. “Étude des mécanismes moléculaires qui contrôlent l’interaction entre EFA6 et ses partenaires : Molecular mechanisms that control the interaction between EFA6 and its partners.” 2015. Doctoral Dissertation, Nice. Accessed January 22, 2020. http://www.theses.fr/2015NICE4081.

MLA Handbook (7^th Edition):

Boulakirba, Sonia. “Étude des mécanismes moléculaires qui contrôlent l’interaction entre EFA6 et ses partenaires : Molecular mechanisms that control the interaction between EFA6 and its partners.” 2015. Web. 22 Jan 2020.

Vancouver:

Boulakirba S. Étude des mécanismes moléculaires qui contrôlent l’interaction entre EFA6 et ses partenaires : Molecular mechanisms that control the interaction between EFA6 and its partners. [Internet] [Doctoral dissertation]. Nice; 2015. [cited 2020 Jan 22]. Available from: http://www.theses.fr/2015NICE4081.

Council of Science Editors:

Boulakirba S. Étude des mécanismes moléculaires qui contrôlent l’interaction entre EFA6 et ses partenaires : Molecular mechanisms that control the interaction between EFA6 and its partners. [Doctoral Dissertation]. Nice; 2015. Available from: http://www.theses.fr/2015NICE4081

Université de Grenoble

3. Rivierre, Yvan. Algorithmes auto-stabilisants pour la construction de structures couvrantes réparties : Self-Stabilizing Algorithms for Constructing Distributed Spanning Structures.

Degree: Docteur es, Informatique, 2013, Université de Grenoble

URL: http://www.theses.fr/2013GRENM089

►

Cette thèse s'intéresse à la construction auto-stabilisante de structures couvrantes dans un système réparti. L'auto-stabilisation est un paradigme pour la tolérance aux fautes dans les… (more)

▼

Cette thèse s'intéresse à la construction auto-stabilisante de structures couvrantes dans un système réparti. L'auto-stabilisation est un paradigme pour la tolérance aux fautes dans les algorithmes répartis. Plus précisément, elle garantit que le système retrouve un comportement correct en temps fini après avoir été perturbé par des fautes transitoires. Notre modèle de système réparti se base sur des mémoires localement partagées pour la communication, des identifiants uniques pour briser les symétries et un ordonnanceur inéquitable, c'est-à-dire le plus faible des ordonnanceurs. Dans la mesure du possible, nous nous imposons d'utiliser les plus faibles hypothèses, afin d'obtenir les constructions les plus générales de structures couvrantes réparties. Nous présentons quatre algorithmes auto-stabilisants originaux pour le k-partitionnement, la construction d'une (f,g)-alliance et l'indexation. Pour chacun de ces problèmes, nous prouvons la correction de nos solutions. De plus, nous analysons leur complexité en temps et en espace à l'aide de preuves formelles et de simulations. Enfin, pour le problème de (f,g)-alliance, nous prenons en compte la notion de convergence sûre qui vient s'ajouter à celle d'auto-stabilisation. Elle garantit d'abord que le comportement du système assure rapidement un minimum de conditions, puis qu'il continue de converger jusqu'à se conformer à une spécification plus exigeante.

This thesis deals with the self-stabilizing construction of spanning structures over a distributed system. Self-stabilization is a paradigm for fault-tolerance in distributed algorithms. It guarantees that the system eventually satisfies its specification after transient faults hit the system. Our model of distributed system assumes locally shared memories for communicating, unique identifiers for symmetry-breaking, and distributed daemon for execution scheduling, that is, the weakest proper daemon. More generally, we aim for the weakest possible assumptions, such as arbitrary topologies, in order to propose the most versatile constructions of distributed spanning structures. We present four original self-stabilizing algorithms achieving k-clustering, (f,g)-alliance construction, and ranking. For every of these problems, we prove the correctness of our solutions. Moreover, we analyze their time and space complexity using formal proofs and simulations. Finally, for the (f,g)-alliance problem, we consider the notion of safe convergence in addition to self-stabilization. It enforces the system to first quickly satisfy a specification that guarantees a minimum of conditions, and then to converge to a more stringent specification.

Advisors/Committee Members: Maraninchi, Florence (thesis director), Carrier, Fabienne (thesis director), Devismes, Stéphane (thesis director).

Subjects/Keywords: Auto-stabilisation; Convergence sûre; Algorithme réparti; K-partitionnement; Ensemble k-dominant; (f; g)-alliance; Self-stabilization; Safe convergence; Distributed algorithm; K-clustering; K-dominating set; (f; g)-alliance; 621

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rivierre, Y. (2013). Algorithmes auto-stabilisants pour la construction de structures couvrantes réparties : Self-Stabilizing Algorithms for Constructing Distributed Spanning Structures. (Doctoral Dissertation). Université de Grenoble. Retrieved from http://www.theses.fr/2013GRENM089

Chicago Manual of Style (16^th Edition):

Rivierre, Yvan. “Algorithmes auto-stabilisants pour la construction de structures couvrantes réparties : Self-Stabilizing Algorithms for Constructing Distributed Spanning Structures.” 2013. Doctoral Dissertation, Université de Grenoble. Accessed January 22, 2020. http://www.theses.fr/2013GRENM089.

MLA Handbook (7^th Edition):

Rivierre, Yvan. “Algorithmes auto-stabilisants pour la construction de structures couvrantes réparties : Self-Stabilizing Algorithms for Constructing Distributed Spanning Structures.” 2013. Web. 22 Jan 2020.

Vancouver:

Rivierre Y. Algorithmes auto-stabilisants pour la construction de structures couvrantes réparties : Self-Stabilizing Algorithms for Constructing Distributed Spanning Structures. [Internet] [Doctoral dissertation]. Université de Grenoble; 2013. [cited 2020 Jan 22]. Available from: http://www.theses.fr/2013GRENM089.

Council of Science Editors:

Rivierre Y. Algorithmes auto-stabilisants pour la construction de structures couvrantes réparties : Self-Stabilizing Algorithms for Constructing Distributed Spanning Structures. [Doctoral Dissertation]. Université de Grenoble; 2013. Available from: http://www.theses.fr/2013GRENM089

4. Younis, Vincent. Att vara välkomen men ändå inte : “Povertyisthemotherofcrime”/MarcusAurelius.

Degree: Care and Social Welfare, 2017, Mälardalen University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-38412

► Studien undersöker invånare och verksammas upplevelser av ett, enligt en rapport frånunderrättelseenheten, utsatt bostadsområde i Västerås. För att besvara frågeställningen har vigenomfört 14 intervjuer… (more)

Subjects/Keywords: u n g d o m a r; b o s t a d s o m r å d e; s y s s e l s ä t t n i n g; s p r i d n i n g; b r o t t; t r y g g h e t; Social Sciences; Samhällsvetenskap

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Younis, V. (2017). Att vara välkomen men ändå inte : “Povertyisthemotherofcrime”/MarcusAurelius. (Thesis). Mälardalen University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-38412

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Younis, Vincent. “Att vara välkomen men ändå inte : “Povertyisthemotherofcrime”/MarcusAurelius.” 2017. Thesis, Mälardalen University. Accessed January 22, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-38412.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Younis, Vincent. “Att vara välkomen men ändå inte : “Povertyisthemotherofcrime”/MarcusAurelius.” 2017. Web. 22 Jan 2020.

Vancouver:

Younis V. Att vara välkomen men ändå inte : “Povertyisthemotherofcrime”/MarcusAurelius. [Internet] [Thesis]. Mälardalen University; 2017. [cited 2020 Jan 22]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-38412.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Younis V. Att vara välkomen men ändå inte : “Povertyisthemotherofcrime”/MarcusAurelius. [Thesis]. Mälardalen University; 2017. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-38412

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Zeitoun, Rina. Méthodes algébriques pour l'analyse de sécurité des implantations d'algorithmes cryptographiques : Algebraic methods for security analysis of cryptographic algorithms implementations.

Degree: Docteur es, Informatique, 2015, Université Pierre et Marie Curie – Paris VI

URL: http://www.theses.fr/2015PA066310

►

Le 10ème problème de Hilbert, consistant à trouver les solutions entières d'équations polynomiales est un problème crucial en cryptanalyse. Si ce dernier a été prouvé… (more)

▼

Le 10ème problème de Hilbert, consistant à trouver les solutions entières d'équations polynomiales est un problème crucial en cryptanalyse. Si ce dernier a été prouvé indécidable, Coppersmith publia en 1996 une méthode basée sur la réduction de réseaux permettant de trouver efficacement l'ensemble des petites solutions de certaines équations polynomiales. De nombreuses applications de cette méthode ont vu le jour dans le domaine de la cryptanalyse à clé publique, notamment lorsque le cryptosystème est exécuté sur un système embarqué et qu'une partie de la clé secrète est dévoilée par la réalisation d'attaques physiques sur le dispositif. Dans ce contexte, nous proposons une attaque physique sur le schéma de signature RSA en mode CRT où une application de la méthode de Coppersmith permet de compléter l'information obtenue par l'attaque physique. Nous proposons également un nouvel algorithme déterministe basé sur la méthode de Coppersmith pour factoriser les entiers de la forme N=p^rq^s en temps polynomial lorsque r ou s sont suffisamment grands. Enfin, si les applications de la méthode de Coppersmith sont nombreuses, en pratique, du fait que les réseaux à réduire soient gigantesques, les petites solutions ne peuvent être retrouvées que jusqu'à une borne qui est plus petite que la borne théorique annoncée. Aussi, une autre contribution de cette thèse consiste en la proposition de deux méthodes permettant une accélération du temps d'exécution de l'algorithme de Coppersmith. Lorsque les deux méthodes sont combinées, le nouvel algorithme s'effectue des centaines de fois plus rapidement pour des paramètres typiques, permettant ainsi dans de nombreux cas d'atteindre la borne théorique.

The 10th Hilbert problem, which consists in finding integer solutions to polynomial equations is a crucial problem in cryptanalysis, which has been proven to be undecidable. However, Coppersmith published in 1996 a method based on lattice reduction, which allows to efficiently find all small solutions to some polynomial equations. Many applications of this method have risen in public key cryptanalysis, especially when the cryptosystem is executed on embedded systems and part of the secret key is revealed through physical attacks performed on the device. In this context, we propose in this thesis a physical attack on the RSA signature scheme when the CRT mode is used, where an application of Coppersmith's method allows to complete the information previously obtained by the physical attack. We also propose a new deterministic algorithm based on Coppersmith's method for factoring integers of the form N=p^rq^s in polynomial time, under the condition that r and/or s are sufficiently large.Finally, if the applications of Coppersmith's method are numerous, in practice, since the lattices to be reduced are huge, the small solutions can only be recovered until a bound which is smaller than the enounced theoretical bound. Thus, another contribution of this thesis lies in the proposition of two methods which allow to speed up the…

Advisors/Committee Members: Faugère, Jean-Charles (thesis director), Renault, Guénaël (thesis director).

Subjects/Keywords: Algorithme de Coppersmith; Canaux cachés; RSA; LLL; Petites solutions d'équations polynomiales; Factoriser N=p^rq^s; Coppersmith's algorithm; Cryptanalysis; 005.8

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zeitoun, R. (2015). Méthodes algébriques pour l'analyse de sécurité des implantations d'algorithmes cryptographiques : Algebraic methods for security analysis of cryptographic algorithms implementations. (Doctoral Dissertation). Université Pierre et Marie Curie – Paris VI. Retrieved from http://www.theses.fr/2015PA066310

Chicago Manual of Style (16^th Edition):

Zeitoun, Rina. “Méthodes algébriques pour l'analyse de sécurité des implantations d'algorithmes cryptographiques : Algebraic methods for security analysis of cryptographic algorithms implementations.” 2015. Doctoral Dissertation, Université Pierre et Marie Curie – Paris VI. Accessed January 22, 2020. http://www.theses.fr/2015PA066310.

MLA Handbook (7^th Edition):

Zeitoun, Rina. “Méthodes algébriques pour l'analyse de sécurité des implantations d'algorithmes cryptographiques : Algebraic methods for security analysis of cryptographic algorithms implementations.” 2015. Web. 22 Jan 2020.

Vancouver:

Zeitoun R. Méthodes algébriques pour l'analyse de sécurité des implantations d'algorithmes cryptographiques : Algebraic methods for security analysis of cryptographic algorithms implementations. [Internet] [Doctoral dissertation]. Université Pierre et Marie Curie – Paris VI; 2015. [cited 2020 Jan 22]. Available from: http://www.theses.fr/2015PA066310.

Council of Science Editors:

Zeitoun R. Méthodes algébriques pour l'analyse de sécurité des implantations d'algorithmes cryptographiques : Algebraic methods for security analysis of cryptographic algorithms implementations. [Doctoral Dissertation]. Université Pierre et Marie Curie – Paris VI; 2015. Available from: http://www.theses.fr/2015PA066310

University of New South Wales

6. Mihova, Marina. The Dream of “La Faustienne” – Reading In-between Language, Image, and Things in the Writing of Lyn Hejinian.

Degree: Arts and Media, 2012, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/53089 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11775/SOURCE01?view=true

► This dissertation examines a terrain of liminality evident in the works of American poet, Lyn Hejinian, whose writing utilizes imagery (ranging from the verbally visual… (more)

▼ This dissertation examines a terrain of liminality evident in the works of American poet, Lyn Hejinian, whose writing utilizes imagery (ranging from the verbally visual to the explicitly graphic) and a form of Steinian materiality, in the development of a poetic which moves away from the domain of textual representation towards a new form of realism which challenges existing notions of ideology and perception.Drawing upon W.J.T. Mitchell’s theories of visuality and Gaston Bachelard’s theorization of the oneiric qualities of writing, as well as on Freudian dream theory, this thesis maps out how the cross disciplinary dimensions of Hejinian’s poetry, render into being a speaking female subject.Chapter one provides a contextual framework for Hejinian’s writing, articulating the integral role notions of community and collaboration play in the development of a form of writing situated within a space of in-between. It examines the significant influence of L=A=N=G=U=A=G=E poetics on Hejinian as a key participant of the Language poetry group, while moving at the same time away from a focus on the specifics of her relation to the group, towards an analysis of her broader writing oeuvre as conversant with a phenomenology of dreams and as a development of a multimodal textuality, distinct from the linguistically centered focus of Language poetry. Chapters two and three present a case for the significance of the visual and the material throughout Hejinian’s writing career, as key textual elements in the composition of a language of experience. This experience-focused language, through thematic concern and philosophical inquiry comprises an active representation of female knowledge and desire, which as Hejinian argues throughout her essay “La Faustienne”, has, not by inadvertence but by definition (Hejinian, The Language of Inquiry: 249), been excluded from the narratives of Western history.Chapters five and six illustrate the multimodal female rhetoric developed in preceding chapters as being a language modeled upon a phenomenology of dreaming. Having been the subject of limited critical attention, Hejinian’s published and unpublished literature on dreams, comprises the central focus of the final two chapters of this dissertation in the development of the chapters’ central claim that, through the composition of a multimodal language, framed and executed through the avenue of experience, Hejinian’s writing project seeks to locate the voice of La Faustienne. Advisors/Committee Members: Olubas, Brigitta, Arts and Media, Faculty of Arts & Social Sciences, UNSW, Brewster, Anne, Arts and Media, Faculty of Arts & Social Sciences, UNSW.

Subjects/Keywords: Lyn Hejinian; Women's writing; L=A=N=G=U=A=G=E writing; Poetry; Visuality; Materiality; Dreams

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mihova, M. (2012). The Dream of “La Faustienne” – Reading In-between Language, Image, and Things in the Writing of Lyn Hejinian. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/53089 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11775/SOURCE01?view=true

Chicago Manual of Style (16^th Edition):

Mihova, Marina. “The Dream of “La Faustienne” – Reading In-between Language, Image, and Things in the Writing of Lyn Hejinian.” 2012. Doctoral Dissertation, University of New South Wales. Accessed January 22, 2020. http://handle.unsw.edu.au/1959.4/53089 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11775/SOURCE01?view=true.

MLA Handbook (7^th Edition):

Mihova, Marina. “The Dream of “La Faustienne” – Reading In-between Language, Image, and Things in the Writing of Lyn Hejinian.” 2012. Web. 22 Jan 2020.

Vancouver:

Mihova M. The Dream of “La Faustienne” – Reading In-between Language, Image, and Things in the Writing of Lyn Hejinian. [Internet] [Doctoral dissertation]. University of New South Wales; 2012. [cited 2020 Jan 22]. Available from: http://handle.unsw.edu.au/1959.4/53089 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11775/SOURCE01?view=true.

Council of Science Editors:

Mihova M. The Dream of “La Faustienne” – Reading In-between Language, Image, and Things in the Writing of Lyn Hejinian. [Doctoral Dissertation]. University of New South Wales; 2012. Available from: http://handle.unsw.edu.au/1959.4/53089 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11775/SOURCE01?view=true

Universidade do Rio Grande do Norte

7. Moreira, Ricardo César de Oliveira. Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio .

Degree: 2012, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/15438

► This work presents a theoretical and experimental analysis about the properties of microstrip antennas with integrated frequency selective surfaces (Frequency Selective Surface - FSS). The… (more)

Subjects/Keywords: antenas patch de microfita; padrões IEEE 802.11 a/b/g/n; superfícies seletivas em frequência; integração; microstrip patch antennas; IEEE standards 802.11 a / b / g / n; frequency selective surfaces; integration

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moreira, R. C. d. O. (2012). Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio . (Masters Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/15438

Chicago Manual of Style (16^th Edition):

Moreira, Ricardo César de Oliveira. “Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio .” 2012. Masters Thesis, Universidade do Rio Grande do Norte. Accessed January 22, 2020. http://repositorio.ufrn.br/handle/123456789/15438.

MLA Handbook (7^th Edition):

Moreira, Ricardo César de Oliveira. “Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio .” 2012. Web. 22 Jan 2020.

Vancouver:

Moreira RCdO. Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio . [Internet] [Masters thesis]. Universidade do Rio Grande do Norte; 2012. [cited 2020 Jan 22]. Available from: http://repositorio.ufrn.br/handle/123456789/15438.

Council of Science Editors:

Moreira RCdO. Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio . [Masters Thesis]. Universidade do Rio Grande do Norte; 2012. Available from: http://repositorio.ufrn.br/handle/123456789/15438

8. Dalier, Fabrice. Stimuli-responsive polymer coatings based on (poly-L-Lysine)-g-poly(N-isopropylacrylamide) to control specific cell adhesion : Revêtements polymères stimulables à base de (poly-L-lysine)-g-poly(N-isopropylacrylamide) pour contrôler l’adhésion cellulaire spécifique.

Degree: Docteur es, Chimie, 2016, Paris Sciences et Lettres

URL: http://www.theses.fr/2016PSLEE019

►

Des revêtements polymères basés sur la physisorption de copolymères en peigne, dérivés du (Poly-L-Lysine)-g-poly(N Isopropylacrylamide) noté PLL-g-PNIPAM, ont été développés afin de contrôler réversiblement l'adhésion… (more)

▼

Des revêtements polymères basés sur la physisorption de copolymères en peigne, dérivés du (Poly-L-Lysine)-g-poly(N Isopropylacrylamide) noté PLL-g-PNIPAM, ont été développés afin de contrôler réversiblement l'adhésion cellulaire. La préparation de ces revêtements repose sur l'adsorption spontanée de la poly(lysine) sur la plupart des substrats anioniques usuels en biologie, aisément mis en oeuvre par le non-spécialiste : une simple immersion du substrat dans une solution de PLL-g-PNIPAM donne une monocouche résistante au rinçage et dense en chaines poly(N-Isopropylacrylamide) thermosensibles.L'adsorption de copolymères en peigne dérivés de la PLL et portant des chaînes latérales de natures variées permet d'ajuster à souhait les propriétés du revêtement. Notre attention s'est portée particulièrement sur l'étude de couchesthermosensibles poly(N-Isopropylacrylamide-coligand), où le ligand est soit un groupe biotine, soit un peptide d'adhésion.Une voie de synthèse générique de dérivés PLL-g- PNIPAM est décrite. Elle se fonde sur la polymérisation RAFT du N-acryloxysuccinimide et la post-modification des unités de répétition puis des extrémités de chaînes. Des mesures de la température de transition soluble/insoluble en solution et des caractérisations par AFM et QCM-d de l'extension des chaînes en surface ont permis de démontrer que la transition au sein des revêtements s'opère à une température proche de celle en solution. La stabilité en termes de composition et d'épaisseur des revêtements suite à des cycles de transitions thermiques a été vérifiée. Une étude de l'adsorption de particules décorées par des protéines comme l'avidine a permis de montrer la capacité des couches adsorbée à exposer/masquer la biotine, et à réguler la formation de liaisons spécifiques par simple changement de température. Pour s'assurer de la possibilité d'ajustement du contraste d'accessibilité de ligands, cette étude a été complétée par des mesures sur des couches mixtes contenant des mélanges de chaînes fonctionnelles ou non fonctionnalisées. Enfin, en utilisant un peptide d'adhésion (RGD) comme ligand, il a été montré que l'interaction avec la surface de cellules HeLA peut être réversiblement contrôlée via une variation de température de quelques degrés, moyennant d'optimiser la densité en peptides et la présence de chaînes répulsives en surface.Un control local par stimulation lumineuse a été envisagé. Des poly(N-Isopropylacrylamide) contenant des azobenzenes furent synthétisés mais ne montrent qu'une faible réponse lumineuse.

Polymer coatings based on the physorption of comb-like polymers, (Poly-L-Lysine)-g-poly(NIsopropylacrylamide)derivatives (PLL-g-PNIPAM), have been developed to reversibly modulate specific cell adhesion on demand.This technique of coating relies on the spontaneous adsorption of PLL on typical anionic substrates used in biology: a simple bath application of substrates in solution of PLLg-PNIPAM affords a stable polymer adlayer with dense and thermoresponsive poly(NIsopropylacrylamide) brushes. Adsorption of…

Advisors/Committee Members: Marie-Begue, Emmanuelle (thesis director).

Subjects/Keywords: Revêtement thermo-stimulable; (Poly-LLysine)- g-poly(N-Isopropylacrylamide); Adsorption; Culture cellulaire; Adhésion spécifique; Thermo-responsive coating; (Poly-L-Lysine)- g-poly(N-Isopropylacrylamide); Adsorption; Cell culture; Specific adhesion; 540

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dalier, F. (2016). Stimuli-responsive polymer coatings based on (poly-L-Lysine)-g-poly(N-isopropylacrylamide) to control specific cell adhesion : Revêtements polymères stimulables à base de (poly-L-lysine)-g-poly(N-isopropylacrylamide) pour contrôler l’adhésion cellulaire spécifique. (Doctoral Dissertation). Paris Sciences et Lettres. Retrieved from http://www.theses.fr/2016PSLEE019

Chicago Manual of Style (16^th Edition):

Dalier, Fabrice. “Stimuli-responsive polymer coatings based on (poly-L-Lysine)-g-poly(N-isopropylacrylamide) to control specific cell adhesion : Revêtements polymères stimulables à base de (poly-L-lysine)-g-poly(N-isopropylacrylamide) pour contrôler l’adhésion cellulaire spécifique.” 2016. Doctoral Dissertation, Paris Sciences et Lettres. Accessed January 22, 2020. http://www.theses.fr/2016PSLEE019.

MLA Handbook (7^th Edition):

Dalier, Fabrice. “Stimuli-responsive polymer coatings based on (poly-L-Lysine)-g-poly(N-isopropylacrylamide) to control specific cell adhesion : Revêtements polymères stimulables à base de (poly-L-lysine)-g-poly(N-isopropylacrylamide) pour contrôler l’adhésion cellulaire spécifique.” 2016. Web. 22 Jan 2020.

Vancouver:

Dalier F. Stimuli-responsive polymer coatings based on (poly-L-Lysine)-g-poly(N-isopropylacrylamide) to control specific cell adhesion : Revêtements polymères stimulables à base de (poly-L-lysine)-g-poly(N-isopropylacrylamide) pour contrôler l’adhésion cellulaire spécifique. [Internet] [Doctoral dissertation]. Paris Sciences et Lettres; 2016. [cited 2020 Jan 22]. Available from: http://www.theses.fr/2016PSLEE019.

Council of Science Editors:

Dalier F. Stimuli-responsive polymer coatings based on (poly-L-Lysine)-g-poly(N-isopropylacrylamide) to control specific cell adhesion : Revêtements polymères stimulables à base de (poly-L-lysine)-g-poly(N-isopropylacrylamide) pour contrôler l’adhésion cellulaire spécifique. [Doctoral Dissertation]. Paris Sciences et Lettres; 2016. Available from: http://www.theses.fr/2016PSLEE019

Universidade do Rio Grande do Norte

9. Moreira, Ricardo César de Oliveira. Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio .

Degree: 2012, Universidade do Rio Grande do Norte

URL: http://repositorio.ufrn.br/handle/123456789/15438

► This work presents a theoretical and experimental analysis about the properties of microstrip antennas with integrated frequency selective surfaces (Frequency Selective Surface - FSS). The… (more)

Subjects/Keywords: antenas patch de microfita; padrões IEEE 802.11 a/b/g/n; superfícies seletivas em frequência; integração; microstrip patch antennas; IEEE standards 802.11 a / b / g / n; frequency selective surfaces; integration

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moreira, R. C. d. O. (2012). Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio . (Thesis). Universidade do Rio Grande do Norte. Retrieved from http://repositorio.ufrn.br/handle/123456789/15438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moreira, Ricardo César de Oliveira. “Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio .” 2012. Thesis, Universidade do Rio Grande do Norte. Accessed January 22, 2020. http://repositorio.ufrn.br/handle/123456789/15438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moreira, Ricardo César de Oliveira. “Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio .” 2012. Web. 22 Jan 2020.

Vancouver:

Moreira RCdO. Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio . [Internet] [Thesis]. Universidade do Rio Grande do Norte; 2012. [cited 2020 Jan 22]. Available from: http://repositorio.ufrn.br/handle/123456789/15438.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moreira RCdO. Antenas planares integradas com FSSs para aplicações em sistemas de comunicações sem fio . [Thesis]. Universidade do Rio Grande do Norte; 2012. Available from: http://repositorio.ufrn.br/handle/123456789/15438

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

10. Surynek, Jiří. Problematika bezdrátových sítí .

Degree: 2010, Brno University of Technology

URL: http://hdl.handle.net/11012/351

► Tato práce se zabývá problematikou bezdrátových sítí. Shrnuje technologie použité pri bezdrátovém pripojení. Zabývá se historií bezdrátového pripojení, ale i nástinem budoucích trendu.; This work… (more)

Subjects/Keywords: Bezdrátové síte; bezdrátové pripojení; Wi-Fi; WiMAX; IEEE 802.11a/b/g/n; IEEE 802.16e.; Key words Wireless networks; wireless connection; Wi-Fi; WiMAX; IEEE 802.11a/b/g/n; IEEE 802.16e.

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Surynek, J. (2010). Problematika bezdrátových sítí . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Surynek, Jiří. “Problematika bezdrátových sítí .” 2010. Thesis, Brno University of Technology. Accessed January 22, 2020. http://hdl.handle.net/11012/351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Surynek, Jiří. “Problematika bezdrátových sítí .” 2010. Web. 22 Jan 2020.

Vancouver:

Surynek J. Problematika bezdrátových sítí . [Internet] [Thesis]. Brno University of Technology; 2010. [cited 2020 Jan 22]. Available from: http://hdl.handle.net/11012/351.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Surynek J. Problematika bezdrátových sítí . [Thesis]. Brno University of Technology; 2010. Available from: http://hdl.handle.net/11012/351

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Brno University of Technology

11. Zikmund, Lukáš. Optimalizace a analýza závislostí komunikačních služeb na zpoždění .

Degree: 2014, Brno University of Technology

URL: http://hdl.handle.net/11012/32919

► Tato diplomová práce je zaměřena na zajištění kvality služeb (QoS) v bezdrátových sítích pro standardy IEEE 802.11 a/b/g/n. První část práce je zaměřena na teoretické… (more)

Subjects/Keywords: Kvalita služeb; zpoždění; kolísání zpoždění; ztrátovost; IEEE 802.11 a/b/g/n; Quality of Service; latency; jitter; packet loss; IEEE 802.11 a/b/g/n

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Zikmund, L. (2014). Optimalizace a analýza závislostí komunikačních služeb na zpoždění . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/32919

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Zikmund, Lukáš. “Optimalizace a analýza závislostí komunikačních služeb na zpoždění .” 2014. Thesis, Brno University of Technology. Accessed January 22, 2020. http://hdl.handle.net/11012/32919.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Zikmund, Lukáš. “Optimalizace a analýza závislostí komunikačních služeb na zpoždění .” 2014. Web. 22 Jan 2020.

Vancouver:

Zikmund L. Optimalizace a analýza závislostí komunikačních služeb na zpoždění . [Internet] [Thesis]. Brno University of Technology; 2014. [cited 2020 Jan 22]. Available from: http://hdl.handle.net/11012/32919.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Zikmund L. Optimalizace a analýza závislostí komunikačních služeb na zpoždění . [Thesis]. Brno University of Technology; 2014. Available from: http://hdl.handle.net/11012/32919

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – Riverside

12. Schacht, Patrick Carl. Characterization of the Non-Receptor GEF, RIC8 with Genetic, Chemical, and Biochemical Analyses.

Degree: Genetics, Genomics and Bioinformatics, 2013, University of California – Riverside

URL: http://www.escholarship.org/uc/item/4f17s6gm

► RIC8 plays a critical role in the regulation of G protein signaling. In this study, a specific chemical inhibitor of the RIC8-GNA-1 interaction is identified.… (more)

Subjects/Keywords: Genetics; Bioinformatics; Biochemistry; Chemical Genomics; GEF; G protein; N. crassa; Neurospora; RIC8

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Schacht, P. C. (2013). Characterization of the Non-Receptor GEF, RIC8 with Genetic, Chemical, and Biochemical Analyses. (Thesis). University of California – Riverside. Retrieved from http://www.escholarship.org/uc/item/4f17s6gm

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Schacht, Patrick Carl. “Characterization of the Non-Receptor GEF, RIC8 with Genetic, Chemical, and Biochemical Analyses.” 2013. Thesis, University of California – Riverside. Accessed January 22, 2020. http://www.escholarship.org/uc/item/4f17s6gm.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Schacht, Patrick Carl. “Characterization of the Non-Receptor GEF, RIC8 with Genetic, Chemical, and Biochemical Analyses.” 2013. Web. 22 Jan 2020.

Vancouver:

Schacht PC. Characterization of the Non-Receptor GEF, RIC8 with Genetic, Chemical, and Biochemical Analyses. [Internet] [Thesis]. University of California – Riverside; 2013. [cited 2020 Jan 22]. Available from: http://www.escholarship.org/uc/item/4f17s6gm.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Schacht PC. Characterization of the Non-Receptor GEF, RIC8 with Genetic, Chemical, and Biochemical Analyses. [Thesis]. University of California – Riverside; 2013. Available from: http://www.escholarship.org/uc/item/4f17s6gm

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New Orleans

13. Komati, Rajesh. Cu (II) Catalyzed Gateways In The Synthesis of Acridine Derivatives and Their Biological Evaluation as Anti-Cancer Drugs.

Degree: PhD, Chemistry, 2014, University of New Orleans

URL: https://scholarworks.uno.edu/td/1818

► Telomeres are nucleoprotein complexes found at the ends of linear eukaryotic chromosomes. Telomeres consist of a short sequence of repetitive double stranded DNA, TTAGGG… (more)

▼ Telomeres are nucleoprotein complexes found at the ends of linear eukaryotic chromosomes. Telomeres consist of a short sequence of repetitive double stranded DNA, TTAGGG repeats in humans (and all mammals), and a complex of 6 proteins, termed the shelterin complex. The length of the telomeres varies greatly between species, from approximately 300 base pairs in yeast to many 10-15 kilo bases in humans, because of the end replication problem this length get shorten with each cell division and ultimately leads to cell death. However the immortal eukaryotic cells and some transformed human cells over come this incomplete end replication problem with the use of enzyme called Telomerase. Telomerase is a ribonucleoprotein enzyme that adds a specific DNA sequence repeats (TTAGGG) to the 3¢ end of DNA strands in the telomere regions. However from the telomerase activity studies, it was concluded that telomerase is active in almost 90% of human cancers but not in normal somatic tissues. Finally, the low or transient expression of telomerase in normal tissues, including normal stem cells, and the generally longer telomeres in normal cells versus tumor cells provide a degree of tumor specificity to telomerase-based drugs and reduce the probability of toxicity to normal tissue. All of these factors suggest that cancer drugs based on telomerase might have a broad therapeutic window. This dissertation focusing on the synthesis of acridine derivatives that have the capability to inhibit the enzyme telomerase. Several N-acridyl maleimide (NAM), N-acridyl succinimide (NAS) and N-acridyl phthalimide (NAP) derivatives have been synthesized and evaluated for their anti cancer activity against various cancer cell lines. While synthesizing acridine derivatives it was required to form the C-N bonds at various stages. Developed a copper-nicotinic acid complex, which catalyzes the coupling of aryl halides with N-formyl amines and cyclic imides to form C-N bond. Explored Cu (II) catalyzed formation of C-N bond by coupling aryl halides with various N-nucleophiles such as formamide, N,N-dimethyl formamide, N-formyl amines and various cyclic imides. Advisors/Committee Members: Prof. Branko S. Jursic.

Subjects/Keywords: Cancer, Acridine Derivatives, G-Quadruplex, Copper, C-N bond; Medicinal-Pharmaceutical Chemistry; Organic Chemistry

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Komati, R. (2014). Cu (II) Catalyzed Gateways In The Synthesis of Acridine Derivatives and Their Biological Evaluation as Anti-Cancer Drugs. (Doctoral Dissertation). University of New Orleans. Retrieved from https://scholarworks.uno.edu/td/1818

Chicago Manual of Style (16^th Edition):

Komati, Rajesh. “Cu (II) Catalyzed Gateways In The Synthesis of Acridine Derivatives and Their Biological Evaluation as Anti-Cancer Drugs.” 2014. Doctoral Dissertation, University of New Orleans. Accessed January 22, 2020. https://scholarworks.uno.edu/td/1818.

MLA Handbook (7^th Edition):

Komati, Rajesh. “Cu (II) Catalyzed Gateways In The Synthesis of Acridine Derivatives and Their Biological Evaluation as Anti-Cancer Drugs.” 2014. Web. 22 Jan 2020.

Vancouver:

Komati R. Cu (II) Catalyzed Gateways In The Synthesis of Acridine Derivatives and Their Biological Evaluation as Anti-Cancer Drugs. [Internet] [Doctoral dissertation]. University of New Orleans; 2014. [cited 2020 Jan 22]. Available from: https://scholarworks.uno.edu/td/1818.

Council of Science Editors:

Komati R. Cu (II) Catalyzed Gateways In The Synthesis of Acridine Derivatives and Their Biological Evaluation as Anti-Cancer Drugs. [Doctoral Dissertation]. University of New Orleans; 2014. Available from: https://scholarworks.uno.edu/td/1818

Université de Neuchâtel

14. Straubhaar, Régis. Numerical optimization of Dirichlet-Laplace eigenvalues on domains in surfaces.

Degree: 2013, Université de Neuchâtel

URL: http://doc.rero.ch/record/32642

► Le spectre de l'opérateur de Laplace-Dirichlet défini sur un domaine borné d'une surface lisse et complète est une suite strictement positive, croissante, tendant vers l'infini.… (more)

Subjects/Keywords: Algorithme d'Uzawa

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Straubhaar, R. (2013). Numerical optimization of Dirichlet-Laplace eigenvalues on domains in surfaces. (Thesis). Université de Neuchâtel. Retrieved from http://doc.rero.ch/record/32642

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Straubhaar, Régis. “Numerical optimization of Dirichlet-Laplace eigenvalues on domains in surfaces.” 2013. Thesis, Université de Neuchâtel. Accessed January 22, 2020. http://doc.rero.ch/record/32642.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Straubhaar, Régis. “Numerical optimization of Dirichlet-Laplace eigenvalues on domains in surfaces.” 2013. Web. 22 Jan 2020.

Vancouver:

Straubhaar R. Numerical optimization of Dirichlet-Laplace eigenvalues on domains in surfaces. [Internet] [Thesis]. Université de Neuchâtel; 2013. [cited 2020 Jan 22]. Available from: http://doc.rero.ch/record/32642.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Straubhaar R. Numerical optimization of Dirichlet-Laplace eigenvalues on domains in surfaces. [Thesis]. Université de Neuchâtel; 2013. Available from: http://doc.rero.ch/record/32642

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

15. Siblini, Wissam. Apprentissage multi label extrême : comparaisons d'approches et nouvelles propositions : Extreme multi-label learning : comparisons of approaches and new proposals.

Degree: Docteur es, Informatique, 2018, Nantes

URL: http://www.theses.fr/2018NANT4083

►

Stimulé par des applications comme l’annotation de documents ou d’images, l’apprentissage multi-label a connu un fort développement cette dernière décennie. Mais les algorithmes classiques se… (more)

▼

Stimulé par des applications comme l’annotation de documents ou d’images, l’apprentissage multi-label a connu un fort développement cette dernière décennie. Mais les algorithmes classiques se heurtent aux nouveaux volumes des données multi-label extrême (XML) où le nombre de labels peut atteindre le million. Cette thèse explore trois directions pour aborder la complexité en temps et en mémoire du problème : la réduction de dimension multi-label, les astuces d’optimisation et d’implémentation et le découpage arborescent. Elle propose d’unifier les approches de réduction à travers une typologie et deux formulations génériques et d’identifier des plus performantes avec une méta-analyse originale des résultats de la littérature. Une nouvelle approche est développée pour analyser l’apport du couplage entre le problème de réduction et celui de classification. Pour réduire la complexité mémoire en maintenant les capacités prédictives, nous proposons également un algorithme d’estimation des plus grands paramètres utiles d’un modèle classique de régression one-vs-rest qui suit une stratégie inspirée de l’analyse de données en flux. Enfin, nous présentons un nouvel algorithme CRAFTML qui apprend un ensemble d’arbres de décision diversifiés. Chaque arbre effectue une réduction aléatoire conjointe des espaces d’attributs et de labels et implémente un partitionnement récursif très rapide. CRAFTML est plus performant que les autres méthodes arborescentes XML et compétitif avec les meilleures méthodes qui nécessitent des supercalculateurs. Les apports de la thèse sont complétés par la présentation d’un outil logiciel VIPE développé avec Orange Labs pour l’analyse d’opinions multi-label.

Stimulated by many applications such as documents or images annotation, multilabel learning have gained a strong interest during the last decade. But, standard algorithms cannot cope with the volumes of the recent extreme multi-label data (XML) where the number of labels can reach millions. This thesis explores three directions to address the complexity in time and memory of the problem: multi-label dimension reduction, optimization and implementation tricks, and tree-based methods. It proposes to unify the reduction approaches through a typology and two generic formulations and to identify the most efficient ones with an original meta-analysis of the results of the literature. A new approach is developed to analyze the interest of coupling the reduction problem and the classification problem. To reduce the memory complexity of a classical one-vs-rest regression model while maintaining its predictive performances, we also propose an algorithm for estimating the largest useful parameters that follows a strategy inspired by data stream analysis. Finally, we present a new algorithm called CRAFTML that learns an ensemble of diversified decision trees. Each tree performs a joint random reduction of the feature and the label spaces and implements a very fast recursive partitioning strategy. CRAFTML performs better than other XML tree-based methods and…

Advisors/Committee Members: Kuntz-Cosperec, Pascale (thesis director), Meyer, Frank (thesis director).

Subjects/Keywords: Algorithme CraftML

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Siblini, W. (2018). Apprentissage multi label extrême : comparaisons d'approches et nouvelles propositions : Extreme multi-label learning : comparisons of approaches and new proposals. (Doctoral Dissertation). Nantes. Retrieved from http://www.theses.fr/2018NANT4083

Chicago Manual of Style (16^th Edition):

Siblini, Wissam. “Apprentissage multi label extrême : comparaisons d'approches et nouvelles propositions : Extreme multi-label learning : comparisons of approaches and new proposals.” 2018. Doctoral Dissertation, Nantes. Accessed January 22, 2020. http://www.theses.fr/2018NANT4083.

MLA Handbook (7^th Edition):

Siblini, Wissam. “Apprentissage multi label extrême : comparaisons d'approches et nouvelles propositions : Extreme multi-label learning : comparisons of approaches and new proposals.” 2018. Web. 22 Jan 2020.

Vancouver:

Siblini W. Apprentissage multi label extrême : comparaisons d'approches et nouvelles propositions : Extreme multi-label learning : comparisons of approaches and new proposals. [Internet] [Doctoral dissertation]. Nantes; 2018. [cited 2020 Jan 22]. Available from: http://www.theses.fr/2018NANT4083.

Council of Science Editors:

Siblini W. Apprentissage multi label extrême : comparaisons d'approches et nouvelles propositions : Extreme multi-label learning : comparisons of approaches and new proposals. [Doctoral Dissertation]. Nantes; 2018. Available from: http://www.theses.fr/2018NANT4083

16. Erbin, Harold. Trous noirs en supergravité N = 2 : Black holes in N = 2 supergravity.

Degree: Docteur es, Physique, 2015, Université Pierre et Marie Curie – Paris VI

URL: http://www.theses.fr/2015PA066367

►

La solution des équations d'Einstein–Maxwell décrivant le trou noir le plus général a été découverte par Plebański et Demiański en 1976. Cette thèse accomplit plusieurs… (more)

▼

La solution des équations d'Einstein–Maxwell décrivant le trou noir le plus général a été découverte par Plebański et Demiański en 1976. Cette thèse accomplit plusieurs étapes en vue d'intégrer une généralisation de cette solution en supergravité jaugée N = 2. Le contenu bosonique de cette dernière comprend la métrique assortie de champs de jauge et de deux types de champs scalaires (appelés scalaires-vecteurs et hyperscalaires); cela implique qu'il est beaucoup plus compliqué de trouver une solution générale et l'on doit se restreindre à des classes particulières de solutions ou bien utiliser des algorithmes pour générer des solutions.Dans la première partie de cette thèse nous approchons ce problème grâce à la première stratégie en nous restreignant aux solutions BPS.Dans un premier temps nous étudions les jaugeages abéliens qui impliquent les hyperscalaires afin de comprendre quelles sont les conditions nécessaires pour obtenir des vides N = 2 adS4 ainsi que des géométries de proche-horizon associées à des trous noirs statiques.Par la suite nous décrivons une solution générale et analytique pour des trous noirs (extrémaux) 1/4-BPS qui possèdent une masse, une charge de NUT, des charges dyoniques et des champs scalaires non-triviaux dans le contexte de la supergravité N = 2 jaugée à la Fayet–Iliopoulos.Dans la seconde partie nous obtenons une extension de l'algorithme de Janis-Newman afin de prendre en compte tous les champs bosoniques de spin inférieur à 2, les horizons topologiques et le cas des autres dimensions.Ainsi cela met à disposition tous les outils nécessaires pour appliquer cet algorithme à la supergravité (jaugée ou non).

The most general black hole solution of Einstein–Maxwell theory has been discovered by Plebański and Demiański in 1976.This thesis provides several steps towards generalizing this solution by embedding it into N = 2 gauged supergravity.The (bosonic fields of the) latter consists in the metric together with gauge fields and two kinds of scalar fields (vector scalars and hyperscalars); as a consequence finding a general solution is involved and one needs to focus on specific subclasses of solutions or to rely on solution generating algorithms. In the first part of the thesis we approach the problem using the first strategy: we restrict our attention to BPS solutions, relying on a symplectic covariant formalism. First we study the possible Abelian gaugings involving the hyperscalars in order to understand which are the necessary conditions for obtaining N = 2 adS4 vacua and near-horizon geometries associated to the asymptotics of static black holes.A preliminary step is to obtain covariant expressions for the Killing vectors of symmetric special quaternionic-Kähler manifolds. Then we describe a general analytic solutions for 1/4-BPS (extremal) black holes with mass, NUT, dyonic charges and running scalars in N = 2 Fayet–Iliopoulos gauged supergravity with a symmetric very special Kähler manifold. In the second part we provide an extension of the Janis–Newman algorithm to all bosonic…

Advisors/Committee Members: Halmagyi, Nick (thesis director).

Subjects/Keywords: Trou noir; Algorithme Janis-Newman; Supergravité n=2; Trou noir en rotation; Espace taub-Nut; Trou noir bps; Black hole; Janis-Newman algorithm; 530

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Erbin, H. (2015). Trous noirs en supergravité N = 2 : Black holes in N = 2 supergravity. (Doctoral Dissertation). Université Pierre et Marie Curie – Paris VI. Retrieved from http://www.theses.fr/2015PA066367

Chicago Manual of Style (16^th Edition):

Erbin, Harold. “Trous noirs en supergravité N = 2 : Black holes in N = 2 supergravity.” 2015. Doctoral Dissertation, Université Pierre et Marie Curie – Paris VI. Accessed January 22, 2020. http://www.theses.fr/2015PA066367.

MLA Handbook (7^th Edition):

Erbin, Harold. “Trous noirs en supergravité N = 2 : Black holes in N = 2 supergravity.” 2015. Web. 22 Jan 2020.

Vancouver:

Erbin H. Trous noirs en supergravité N = 2 : Black holes in N = 2 supergravity. [Internet] [Doctoral dissertation]. Université Pierre et Marie Curie – Paris VI; 2015. [cited 2020 Jan 22]. Available from: http://www.theses.fr/2015PA066367.

Council of Science Editors:

Erbin H. Trous noirs en supergravité N = 2 : Black holes in N = 2 supergravity. [Doctoral Dissertation]. Université Pierre et Marie Curie – Paris VI; 2015. Available from: http://www.theses.fr/2015PA066367

Texas A&M University

17. Them, Theodore. Tropical North Atlantic Hydrologic Cycle Variability in the Florida Straits During the Last Ice Age.

Degree: 2012, Texas A&M University

URL: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11593

► Abrupt, millennial-scale climate oscillations, known as Dansgaard-Oeschger (D-O) cycles, characterized the climate system during the last ice age. Proxy evidence suggests these climate oscillations resulted… (more)

▼ Abrupt, millennial-scale climate oscillations, known as Dansgaard-Oeschger (D-O) cycles, characterized the climate system during the last ice age. Proxy evidence suggests these climate oscillations resulted in global-scale reorganizations in the hydrological cycle. For this study, Mg/Ca-paleothermometry and stable isotope measurements were combined on the planktonic foraminifera Globigerinoides ruber (white variety) from Florida Straits sediment core KNR166-2 JPC26 (24*19.61'N, 83*15.14'W; 546 m depth) to reconstruct a high-resolution record of sea surface temperature and delta18OSW (a proxy for upper water column salinity) during Marine Isotope Stages 2 and 3 from 20-35.45 ka BP. As additional proxies for upper water column salinity change, Ba/Ca ratios in G. ruber were also measured to determine the relative contribution of local riverine input on the delta18OSW record and a faunal abundance count record of the planktonic foraminifera N. dutertrei abundance was developed. These results show that rapid upper water column salinity changes occurred across D-O events in the Florida Straits, coeval with climate change in the high-latitude North Atlantic. Furthermore, the G. ruber Ba/Ca record suggests that riverine-derived meltwater from the Gulf of Mexico did not significantly impact surface salinity in the Florida current, calling into question the role of Mississippi River discharge on Atlantic Meridional Overturning Circulation (AMOC) during MIS 2 and 3. Instead, the most likely cause of MIS 2 and 3 salinity changes in the Florida Straits were variations in the strength and position of the Intertropical Convergence Zone. Finally, the timing of surface salinity change was compared with the benthic delta18OC record from the same core. A recent study showed that benthic delta18OC changes on the Florida Margin can be combined with contemporaneous records from the Bahamas Margin to reconstruct Florida Current transport related to AMOC variability. These results show that atmospheric circulation changes lead AMOC changes on the transition out of cold stadial events, suggesting the trigger for these abrupt climate events may reside in the tropics rather than in the high-latitude North Atlantic as previously thought. Advisors/Committee Members: Schmidt, Matthew W. (advisor), Slowey, Niall C. (committee member), Marcantonio, Franco (committee member).

Subjects/Keywords: Mg/Ca thermometry; G. ruber; N. dutertrei; Paleoclimate; Dansgaard-Oeschger event; ITCZ; Tropical SSS; Tropical SST

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Them, T. (2012). Tropical North Atlantic Hydrologic Cycle Variability in the Florida Straits During the Last Ice Age. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11593

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Them, Theodore. “Tropical North Atlantic Hydrologic Cycle Variability in the Florida Straits During the Last Ice Age.” 2012. Thesis, Texas A&M University. Accessed January 22, 2020. http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11593.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Them, Theodore. “Tropical North Atlantic Hydrologic Cycle Variability in the Florida Straits During the Last Ice Age.” 2012. Web. 22 Jan 2020.

Vancouver:

Them T. Tropical North Atlantic Hydrologic Cycle Variability in the Florida Straits During the Last Ice Age. [Internet] [Thesis]. Texas A&M University; 2012. [cited 2020 Jan 22]. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11593.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Them T. Tropical North Atlantic Hydrologic Cycle Variability in the Florida Straits During the Last Ice Age. [Thesis]. Texas A&M University; 2012. Available from: http://hdl.handle.net/1969.1/ETD-TAMU-2012-08-11593

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

18. Kovács, József. Call Centerek Matematikai Modellezése .

Degree: DE – TEK – Informatikai Kar, 2009, University of Debrecen

URL: http://hdl.handle.net/2437/87268

► A dolgozatom során a bevezető részen túl, négy különböző, de egymással szoros kapcsolatban álló rendszert elemző forrásokat rendeztem egyfajta logikai sorrendbe. Először az Erlang C… (more)

▼ A dolgozatom során a bevezető részen túl, négy különböző, de egymással szoros kapcsolatban álló rendszert elemző forrásokat rendeztem egyfajta logikai sorrendbe. Először az Erlang C került vizsgálódásom középpontjába, amely egyszerűségével igen vonzó a Call Center menedzserek számára. Gyors és pontos algoritmus létezik a kiszámítására, ahogy azt a 6.5. fejezetben idézett forrás is részletesen leírja. Azonban ennek a rendszernek komoly hiányosságai is vannak. Az első abból adódik, hogy lényegében azonos híváskezelési időkkel számol, amely nem mindig tartható feltételezés. Ennek feloldását tárgyalja a 7. fejezet, amely aszimptotikus közelítést ad a késleltetési valószínűségekre, és ebből származtatja a TSF-et és az ASA-t. Ebben a fejezetben lesz említve először az iparágban létező három létszámfeltöltési rezsim, irányvonal, amelyeket egyenként Hatékonyság-, Minőségvezéreltnek és Racionalizáltnak nevezünk. Fontos megemlíteni a szolgáltatási gradienst, amelynek szinten tartása a Racionalizált rezsim feladata, a többletlétszám (Hatékonyságvezérelt) vagy a rendszerkihasználtság (Minőségvezérelt) szinten tartásával szemben. A Racionalizált rezsimnek ugyanez a célja az Erlang A rendszerben is. Az Erlang C végtelen türelmet feltételez a hívók részéről, ami torlódás esetén 0 TSF-hez vezet, amelynek elkerülése a Call Center menedzserek elsődleges célja. A trunk vonalak számának beállíthatósága olyan eszköz a kezükben, amellyel elkerülhetik az ilyen túlterhelési szituációkat, cserébe lesznek olyan ügyfelek, amelyek foglalt jelzést kapnak. Ezeknek az arányáról ad pontos képet a 8. fejezet, amely az Erlang B modellel kapcsolatos forrásokból építkezik. Szintén létezik pontos és valós időben számoló algoritmus, amelyet a 8.3. fejezet ismertet olyan rendszerekben, ahol a késleltetés valószínűsége nulla ( 0 sorhossz ). Végül az Erlang A modellel foglalkozó cikkekből merít a diplomamunkám. A 9.2 fejezetben látható egy olyan modell, amelyben a különböző, eddig tárgyalt rendszerek ismérvei vannak összegyúrva. Ebben a modellben, ha valaki szabad az N számú kiszolgáló közül, akkor a hívás azonnal oda lesz irányítva. Ha nem, de N < B ahol B a trunk vonalak száma, és van szabad hely a maximálisan B - N hosszúságú sorban, akkor ott kell várakoznia a hívásnak. A többi foglalt jelzést kap. Ebben a fejezetben a középponti kérdés a sorban várakozó ügyfelek sorsa, amelyek az Erlang C modellel ellentétben nem várnak örökké, hanem feladják a hívást. Ennek az aránynak a számítása fontos hatékonyságmutató ebben a modellben az ASA, TSF és a Blokkolási valószínűség mellett, amelyeket már az előző modellekben is említettünk. Létezik pontos számítás, amelyeket a források segítségével a 9.3. fejezetben említek. De ennél is fontosabbak a közelítések, amelyek kellően pontosak, és valós időben számolhatóak (9.5.3. fejezet ). A 9. fejezetet a többletlétszám kiszámítására adott gyakorlati szabályok ismertetésével fejezem be a 3 különböző rezsimben. Advisors/Committee Members: Sztrik, János (advisor).

Subjects/Keywords: Erlang A; Erlang B; Erlang C; M/G/N

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kovács, J. (2009). Call Centerek Matematikai Modellezése . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/87268

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kovács, József. “Call Centerek Matematikai Modellezése .” 2009. Thesis, University of Debrecen. Accessed January 22, 2020. http://hdl.handle.net/2437/87268.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kovács, József. “Call Centerek Matematikai Modellezése .” 2009. Web. 22 Jan 2020.

Vancouver:

Kovács J. Call Centerek Matematikai Modellezése . [Internet] [Thesis]. University of Debrecen; 2009. [cited 2020 Jan 22]. Available from: http://hdl.handle.net/2437/87268.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kovács J. Call Centerek Matematikai Modellezése . [Thesis]. University of Debrecen; 2009. Available from: http://hdl.handle.net/2437/87268

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Edith Cowan University

19. Yu, Xinwei. Immunoglobulin G N-glycan profiling as a risk stratification biomarker for type 2 diabetes.

Degree: 2019, Edith Cowan University

URL: https://ro.ecu.edu.au/theses/2199

► Objective Type 2 diabetes (T2DM) is a complicated and comprehensive disease that has many metabolic facets with its prevalence increasing with age. The inflammation hypothesis… (more)

▼ Objective Type 2 diabetes (T2DM) is a complicated and comprehensive disease that has many metabolic facets with its prevalence increasing with age. The inflammation hypothesis of T2DM was proposed at the American Diabetes Association’s 65th scientific session and subsequently validated in many studies. Immunoglobulin G (IgG) is the main component of antibody formation after a secondary immune response and therefore plays an important role in the inflammation cascade and in the occurrence and development of age-related diseases. N-glycosylation, an important post-translation modifying process, significantly affects the function of IgG molecules, including complement activation, receptor binding properties, molecular recognition and aggregation. As T2DM is a low-grade chronic inflammatory disease and IgG N-glycosylation involves in the inflammation cascade, we hypothesised that IgG N-glycans could be involved in pathophysiological process of T2DM. To provide clues to the molecular mechanisms, and screen intervention targets and search for early diagnosis marker of T2DM, we conducted an observational study analyzing the correlation between IgG N-glycans and aging, and age-related disease, T2DM. Methods This was an observational study with a longitudinal design. A community-based cohort in Beijing Xicheng district was established in 2012, and 701 participants aged from 23 to 68 (244 males and 457 females) were recruited. Demographic information and 39 clinical traits (7 anthropometric, 10 biochemical and 22 hematological) were collected and blood was sampled for plasma IgG N-glycans analysis using Ultra performance liquid chromatography (UPLC). From the glycan testing platform, 22 IgG N-glycan chromatographic peaks were detected and then 22 basic glycan traits (GP1-2, GP4-19, GP21-24) were calculated from the relative contributions of individual peaks to the total IgG N-glyans. Based on the 22 basic glycan traits, 54 derived glycan traits (17 derived basic glycan traits, 14 neutral glycan traits, 23 derived neutral glycan traits) were obtained for describing glycosylation character in details. In 2014, a sample of 516 participants (160 males and 356 females), aged from 26 to 66 were re-investigated in a follow-up survey and the same clinical traits were collected. All the statistical analyses were performed with SPSS 23.0 and R programming language software. All reported P values were 2-sided and PN-glycans and level of fasting plasma glucose (FPG). Canonical correlation analysis (CAA) was used to determine the integrate correlation between IgG N-glycans and clinical traits. The potential of IgG N-glycans to be a biomarker of T2DM was analysed by receiver-operating characteristic (ROC) curve and decision tree methods. The relationship between IgG N-glycan traits and age was assessed by all-subsets regression, binominal regression and permutation test. Results 1. Screening IgG N-Glycans for type 2 diabetes A sample of 701 participants from the baseline survey was categorised into three groups according to their FPG…

Subjects/Keywords: Immunoglobulin G N-glycans; type 2 diabetes; fasting plasma glucose; age; biomarker; Han Chinese population; Diagnosis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Yu, X. (2019). Immunoglobulin G N-glycan profiling as a risk stratification biomarker for type 2 diabetes. (Thesis). Edith Cowan University. Retrieved from https://ro.ecu.edu.au/theses/2199

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Yu, Xinwei. “Immunoglobulin G N-glycan profiling as a risk stratification biomarker for type 2 diabetes.” 2019. Thesis, Edith Cowan University. Accessed January 22, 2020. https://ro.ecu.edu.au/theses/2199.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Yu, Xinwei. “Immunoglobulin G N-glycan profiling as a risk stratification biomarker for type 2 diabetes.” 2019. Web. 22 Jan 2020.

Vancouver:

Yu X. Immunoglobulin G N-glycan profiling as a risk stratification biomarker for type 2 diabetes. [Internet] [Thesis]. Edith Cowan University; 2019. [cited 2020 Jan 22]. Available from: https://ro.ecu.edu.au/theses/2199.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Yu X. Immunoglobulin G N-glycan profiling as a risk stratification biomarker for type 2 diabetes. [Thesis]. Edith Cowan University; 2019. Available from: https://ro.ecu.edu.au/theses/2199

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cambridge

20. Watson, Joanna. Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP.

Degree: PhD, 2017, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/268520

► Cdc42 is a member of the Rho family of small GTPases, which, together with its homologues RhoA and Rac1, controls a multitude of cellular functions… (more)

▼ Cdc42 is a member of the Rho family of small GTPases, which, together with its homologues RhoA and Rac1, controls a multitude of cellular functions via the actin cytoskeleton. Cdc42 exerts its effects on the cytoskeleton via effector proteins of the Wiskott-Aldrich Syndrome (WASP) family and the Transducer of Cdc42-dependent Actin assembly (TOCA) family. The WASP family and their activation by Cdc42 have been thoroughly studied in vitro and are well understood. Conversely, understanding of the TOCA family remains limited by a lack of biochemical, biophysical and structural insight. An investigation of the TOCA1-Cdc42 interaction is described here, revealing a relatively low affinity interaction with a dissociation constant in the micromolar range. This is 10-100x weaker than other Rho-effector interactions and suggests that TOCA1 must first be co-localised with Cdc42 to achieve stable binding in vivo. The solution NMR structure of the Cdc42 binding HR1 domain of TOCA1 provides the first structural data on this protein and reveals some interesting structural features that may relate to binding affinity and specificity. A structural model of the Cdc42-HR1 complex provides further insight into differential specificities and affinities of GTPase-effector interactions. NMR and actin polymerisation assays provide insight into the pathway of Cdc42/TOCA1/WASP-dependent actin assembly, suggesting unidirectional displacement of TOCA1 by N-WASP. A comparison of the Cdc42- TOCA1 model with an NMR structure of Cdc42 in complex with the GTPase binding domain of WASP reveals a possible mechanism by which an ‘effector handover’ from TOCA1 to N-WASP could take place. Small GTPases such as Cdc42 are lipid modified and membrane anchored via their C- termini in vivo, so in vitro studies using truncated, unmodified GTPases are limited in their biological interpretation. This project also aimed to develop methods to study full length and membrane-anchored GTPases in vitro. Lipid modified protein was produced, which showed a weak affinity for liposomes, and so structural studies of membrane anchored protein are within reach. Further method development is now required to achieve stable membrane anchoring of lipid modified GTPases for detailed NMR studies.

Subjects/Keywords: Cdc42; NMR; TOCA1; NWASP; WASL; N-WASP; GTPase; G protein; HR1 domain; Filopodia; Endocytosis; Cell signalling; Protein protein interaction

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Watson, J. (2017). Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/268520

Chicago Manual of Style (16^th Edition):

Watson, Joanna. “Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP.” 2017. Doctoral Dissertation, University of Cambridge. Accessed January 22, 2020. https://www.repository.cam.ac.uk/handle/1810/268520.

MLA Handbook (7^th Edition):

Watson, Joanna. “Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP.” 2017. Web. 22 Jan 2020.

Vancouver:

Watson J. Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP. [Internet] [Doctoral dissertation]. University of Cambridge; 2017. [cited 2020 Jan 22]. Available from: https://www.repository.cam.ac.uk/handle/1810/268520.

Council of Science Editors:

Watson J. Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP. [Doctoral Dissertation]. University of Cambridge; 2017. Available from: https://www.repository.cam.ac.uk/handle/1810/268520

University of Cambridge

21. Watson, Joanna. Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP.

Degree: PhD, 2017, University of Cambridge

URL: https://www.repository.cam.ac.uk/handle/1810/268520 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744281

► Cdc42 is a member of the Rho family of small GTPases, which, together with its homologues RhoA and Rac1, controls a multitude of cellular functions… (more)

▼ Cdc42 is a member of the Rho family of small GTPases, which, together with its homologues RhoA and Rac1, controls a multitude of cellular functions via the actin cytoskeleton. Cdc42 exerts its effects on the cytoskeleton via effector proteins of the Wiskott-Aldrich Syndrome (WASP) family and the Transducer of Cdc42-dependent Actin assembly (TOCA) family. The WASP family and their activation by Cdc42 have been thoroughly studied in vitro and are well understood. Conversely, understanding of the TOCA family remains limited by a lack of biochemical, biophysical and structural insight. An investigation of the TOCA1-Cdc42 interaction is described here, revealing a relatively low affinity interaction with a dissociation constant in the micromolar range. This is 10-100x weaker than other Rho-effector interactions and suggests that TOCA1 must first be co-localised with Cdc42 to achieve stable binding in vivo. The solution NMR structure of the Cdc42 binding HR1 domain of TOCA1 provides the first structural data on this protein and reveals some interesting structural features that may relate to binding affinity and specificity. A structural model of the Cdc42-HR1 complex provides further insight into differential specificities and affinities of GTPase-effector interactions. NMR and actin polymerisation assays provide insight into the pathway of Cdc42/TOCA1/WASP-dependent actin assembly, suggesting unidirectional displacement of TOCA1 by N-WASP. A comparison of the Cdc42- TOCA1 model with an NMR structure of Cdc42 in complex with the GTPase binding domain of WASP reveals a possible mechanism by which an ‘effector handover’ from TOCA1 to N-WASP could take place. Small GTPases such as Cdc42 are lipid modified and membrane anchored via their C- termini in vivo, so in vitro studies using truncated, unmodified GTPases are limited in their biological interpretation. This project also aimed to develop methods to study full length and membrane-anchored GTPases in vitro. Lipid modified protein was produced, which showed a weak affinity for liposomes, and so structural studies of membrane anchored protein are within reach. Further method development is now required to achieve stable membrane anchoring of lipid modified GTPases for detailed NMR studies.

Subjects/Keywords: Cdc42; NMR; TOCA1; NWASP; WASL; N-WASP; GTPase; G protein; HR1 domain; Filopodia; Endocytosis; Cell signalling; Protein protein interaction

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Watson, J. (2017). Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/268520 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744281

Chicago Manual of Style (16^th Edition):

Watson, Joanna. “Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP.” 2017. Doctoral Dissertation, University of Cambridge. Accessed January 22, 2020. https://www.repository.cam.ac.uk/handle/1810/268520 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744281.

MLA Handbook (7^th Edition):

Watson, Joanna. “Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP.” 2017. Web. 22 Jan 2020.

Vancouver:

Watson J. Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP. [Internet] [Doctoral dissertation]. University of Cambridge; 2017. [cited 2020 Jan 22]. Available from: https://www.repository.cam.ac.uk/handle/1810/268520 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744281.

Council of Science Editors:

Watson J. Structural and biochemical insight into the interactions of Cdc42 with TOCA1 and N-WASP. [Doctoral Dissertation]. University of Cambridge; 2017. Available from: https://www.repository.cam.ac.uk/handle/1810/268520 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.744281

22. Laouar-Meftah, Siham. Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement.

Degree: 2010, Université M'Hamed Bougara Boumerdès

URL: http://dlibrary.univ-boumerdes.dz:8080123456789/1847

►

138 p. : ill. ; 30 cm

Le but de ce travail est d’étudier numériquement, en régime stationnaire, l’effet du rayonnement de gaz réels sur… (more)

Subjects/Keywords: Transfert radiatif; Algorithme

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Laouar-Meftah, S. (2010). Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement. (Thesis). Université M'Hamed Bougara Boumerdès. Retrieved from http://dlibrary.univ-boumerdes.dz:8080123456789/1847

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Laouar-Meftah, Siham. “Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement.” 2010. Thesis, Université M'Hamed Bougara Boumerdès. Accessed January 22, 2020. http://dlibrary.univ-boumerdes.dz:8080123456789/1847.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Laouar-Meftah, Siham. “Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement.” 2010. Web. 22 Jan 2020.

Vancouver:

Laouar-Meftah S. Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement. [Internet] [Thesis]. Université M'Hamed Bougara Boumerdès; 2010. [cited 2020 Jan 22]. Available from: http://dlibrary.univ-boumerdes.dz:8080123456789/1847.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Laouar-Meftah S. Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement. [Thesis]. Université M'Hamed Bougara Boumerdès; 2010. Available from: http://dlibrary.univ-boumerdes.dz:8080123456789/1847

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Laouar Meftah, Siham. Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement.

Degree: 2010, Université M'Hamed Bougara Boumerdès

URL: http://dlibrary.univ-boumerdes.dz:8080/jspui/handle/123456789/776

►

138 p. ; ill. ; 30 cm

Le but de ce travail est d’étudier numériquement, en régime stationnaire, l’effet du rayonnement de gaz réels sur… (more)

Subjects/Keywords: Transfert radiatif; Algorithme

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Laouar Meftah, S. (2010). Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement. (Thesis). Université M'Hamed Bougara Boumerdès. Retrieved from http://dlibrary.univ-boumerdes.dz:8080/jspui/handle/123456789/776

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Laouar Meftah, Siham. “Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement.” 2010. Thesis, Université M'Hamed Bougara Boumerdès. Accessed January 22, 2020. http://dlibrary.univ-boumerdes.dz:8080/jspui/handle/123456789/776.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Laouar Meftah, Siham. “Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement.” 2010. Web. 22 Jan 2020.

Vancouver:

Laouar Meftah S. Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement. [Internet] [Thesis]. Université M'Hamed Bougara Boumerdès; 2010. [cited 2020 Jan 22]. Available from: http://dlibrary.univ-boumerdes.dz:8080/jspui/handle/123456789/776.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Laouar Meftah S. Modélisation de la convection naturelle de double diffusion dans un mélange de gaz absorbant et émettant le rayonnement. [Thesis]. Université M'Hamed Bougara Boumerdès; 2010. Available from: http://dlibrary.univ-boumerdes.dz:8080/jspui/handle/123456789/776

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

24. Langueh, Amavi Mawulé Guissou. Contribution au dimensionnement des roues ferroviaires en fatigue de contact de roulement : Contribution to the design of railway wheels in rolling contact fatigue.

Degree: Docteur es, Mécanique, 2013, Université Lille I – Sciences et Technologies

URL: http://www.theses.fr/2013LIL10035

►

L'augmentation des charges transportées par essieu, des vitesses de circulation et l’état des voies peuvent conduire à des endommagements des roues en surface ou sous-surface,… (more)

▼

L'augmentation des charges transportées par essieu, des vitesses de circulation et l’état des voies peuvent conduire à des endommagements des roues en surface ou sous-surface, généralement appelés écaillage. L’objectif de cette thèse est de développer une approche complète de dimensionnement des roues ferroviaires en fatigue de roulement permettant de prendre en compte les sollicitations locales via la géométrie réelle du contact roue/rail, le comportement inélastique du matériau de la roue (acier) et les conditions d'exploitation. A l’heure actuelle, les méthodes de dimensionnement des roues ne permettent pas de prendre en tous ces éléments au travers d’une même simulation. L’algorithme stationnaire fondé sur la formulation eulérienne est utilisé pour déterminer l’état stabilisé de la structure. L’influence du glissement, du mésalignement, de la position du chargement, et de la nuance d’aciers sur la réponse mécanique, les trajets de chargement en fatigue et la limite d’adaptation a été étudiée. Les critères de fatigue de Dang Van et de Manson-Coffin sont principalement utilisés pour l’analyse en fatigue. Les résultats obtenus permettent la construction de cartes d’adaptation numérique et celles-ci sont alors discutées. D'autre part, l’influence des contraintes résiduelles introduites par le traitement thermique de la bande de roulement est analysée. Il est montré qu’elles modifient les contraintes hydrostatiques comme c'est généralement le cas en fatigue, mais aussi le cisaillement mésoscopique, qui constitue un résultat nouveau.

The increasing of the railways axles loads; the traffic speeds and track conditions can lead to surface and sub-surface damage of wheel, usually called scaling. The aim of this thesis is to develop a numerical approach of railways wheel design in rolling contact fatigue which takes into account the local solicitations via the real geometric of rail/wheel contact, the inelastic behavior of the wheel material (steel) and the operating conditions. At present, the simplified methods for the wheel design are not possible to take all these elements through a single simulation. The stationary algorithm based on the Eulerian formulation is used to determine the steady state of the structure. The influence of the slip, the slip angle, the position of the load and the steel grades on the mechanical response, the fatigue loading paths and the shakedown are investigated. For the fatigue analysis, the criteria of Dang Van and Manson-Coffin are used. The results allow the establishment of the numerical shakedown maps and these are then discussed. Furthermore, the influence of residual stresses introduced by the heat treatment of the tread is analysed. It is shown that they modify the hydrostatic pressure as it is usually the case in fatigue, but also the mesoscopic shear stress, which is a new result.

Advisors/Committee Members: Dufrénoy, Philippe (thesis director), Charkaluk, Éric (thesis director), Brunel, Jean-François (thesis director).

Subjects/Keywords: Algorithme stationnaire; 625.21

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Langueh, A. M. G. (2013). Contribution au dimensionnement des roues ferroviaires en fatigue de contact de roulement : Contribution to the design of railway wheels in rolling contact fatigue. (Doctoral Dissertation). Université Lille I – Sciences et Technologies. Retrieved from http://www.theses.fr/2013LIL10035

Chicago Manual of Style (16^th Edition):

Langueh, Amavi Mawulé Guissou. “Contribution au dimensionnement des roues ferroviaires en fatigue de contact de roulement : Contribution to the design of railway wheels in rolling contact fatigue.” 2013. Doctoral Dissertation, Université Lille I – Sciences et Technologies. Accessed January 22, 2020. http://www.theses.fr/2013LIL10035.

MLA Handbook (7^th Edition):

Langueh, Amavi Mawulé Guissou. “Contribution au dimensionnement des roues ferroviaires en fatigue de contact de roulement : Contribution to the design of railway wheels in rolling contact fatigue.” 2013. Web. 22 Jan 2020.

Vancouver:

Langueh AMG. Contribution au dimensionnement des roues ferroviaires en fatigue de contact de roulement : Contribution to the design of railway wheels in rolling contact fatigue. [Internet] [Doctoral dissertation]. Université Lille I – Sciences et Technologies; 2013. [cited 2020 Jan 22]. Available from: http://www.theses.fr/2013LIL10035.

Council of Science Editors:

Langueh AMG. Contribution au dimensionnement des roues ferroviaires en fatigue de contact de roulement : Contribution to the design of railway wheels in rolling contact fatigue. [Doctoral Dissertation]. Université Lille I – Sciences et Technologies; 2013. Available from: http://www.theses.fr/2013LIL10035

25. Momège, Benjamin. Autour de la connexité dans les graphes avec conflits : On the Connectivity of Graphs with Conflicts.

Degree: Docteur es, Informatique, 2015, Université Blaise-Pascale, Clermont-Ferrand II

URL: http://www.theses.fr/2015CLF22588

►

Nous nous intéresserons aux graphes avec conflits (un conflit est une paire d’arêtes ne pouvant pas simultanément faire partie d’un même sous-graphe), dans lesquels nous… (more)

Subjects/Keywords: Graphe; Conflit; Transition Interdite; Connexité; Chemin; Parcours; Arbre; Condition Hamiltonienne; Algorithme Exact; \mathcal{N P}-Complétude; Graph; Conflict; Forbidden Transition; Connectivity; Path; Walk; Tree; Hamiltonian Condition; Exact Algorithm; \mathcal{N P}-Completeness

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Momège, B. (2015). Autour de la connexité dans les graphes avec conflits : On the Connectivity of Graphs with Conflicts. (Doctoral Dissertation). Université Blaise-Pascale, Clermont-Ferrand II. Retrieved from http://www.theses.fr/2015CLF22588

Chicago Manual of Style (16^th Edition):

Momège, Benjamin. “Autour de la connexité dans les graphes avec conflits : On the Connectivity of Graphs with Conflicts.” 2015. Doctoral Dissertation, Université Blaise-Pascale, Clermont-Ferrand II. Accessed January 22, 2020. http://www.theses.fr/2015CLF22588.

MLA Handbook (7^th Edition):

Momège, Benjamin. “Autour de la connexité dans les graphes avec conflits : On the Connectivity of Graphs with Conflicts.” 2015. Web. 22 Jan 2020.

Vancouver:

Momège B. Autour de la connexité dans les graphes avec conflits : On the Connectivity of Graphs with Conflicts. [Internet] [Doctoral dissertation]. Université Blaise-Pascale, Clermont-Ferrand II; 2015. [cited 2020 Jan 22]. Available from: http://www.theses.fr/2015CLF22588.

Council of Science Editors:

Momège B. Autour de la connexité dans les graphes avec conflits : On the Connectivity of Graphs with Conflicts. [Doctoral Dissertation]. Université Blaise-Pascale, Clermont-Ferrand II; 2015. Available from: http://www.theses.fr/2015CLF22588

University of Oulu

26. Markkanen, P. (Piia). Human δ opioid receptor:the effect of Phe27Cys polymorphism, N-linked glycosylation and SERCA2b interaction on receptor processing and trafficking.

Degree: 2012, University of Oulu

URL: http://urn.fi/urn:isbn:9789514298219

►

Abstract The delta opioid receptor (δOR) is a member of the G protein-coupled receptor family. This transmembrane receptor has an important role in the regulation… (more)

▼

Abstract The delta opioid receptor (δOR) is a member of the G protein-coupled receptor family. This transmembrane receptor has an important role in the regulation of pain. The OPRD1 gene that encodes the human δOR (hδOR) contains at least 11 single-nucleotide polymorphisms (SNPs). The only nonsynonymous SNP resides in the amino-terminal (N-terminal) domain of the receptor and it replaces Phe at position 27 with Cys, thus introducing an unpaired Cys residue on the extracellular surface of the receptor. The Cys27 variant has been shown to have an allelic frequency of about 10% in Caucasian populations. The polymorphic site is flanked by two putative N-glycosylation sites at Asn18 and Asn33. In this study, the folding, maturation and trafficking of hδOR was assessed using the hδORPhe27 and hδORCys27 variants and the N-glycosylation deficient forms of the latter as models in a heterologous expression system. The effects of N-glycosylation and the unpaired Cys-residue were studied with various biochemical, pharmacological and cell biological methods. In addition, protein-protein interactions of the intracellular hδOR precursors were assessed. The hδORCys27 and hδORPhe27 variants differed significantly in their subcellular localization and maturation efficiency. The newly synthesized hδORCys27 was found to accumulate in the endoplasmic reticulum (ER) prior to its ER-associated degradation in proteasomes. Although a slow maturation rate was characteristic for both variants, only the hδORCys27 had poor maturation efficiency. The cell surface expression of hδORCys27 was further decreased because the constitutive internalization of this receptor was enhanced compared to hδORPhe27. N-linked glycosylation was not required for hδOR function or ligand binding, but was important for the expression of the correctly folded receptor species at the cell surface. The mutant non-N-glycosylated receptor was shown to traffic to the cell surface with enhanced kinetics, but some of the plasma membrane receptors were in a nonnative conformation. Also, the overall levels of the non-N-glycosylated hδORCys27 were decreased as the receptor was efficiently internalized for lysosomal degradation in a constitutive fashion. The hδORCys27 and hδORPhe27 precursors were found to interact with several ER localized proteins, such as calnexin (CNX), protein disulfide isomerase (PDI) and ERp72. The receptors also associated with the sarco(endo)plasmic reticulum calcium ATPase 2b (SERCA2b), which was shown to occur during translocation of the receptor to the ER membrane or immediately thereafter. The interaction was not receptor N-glycan dependent and the normal functional activity of SERCA2b was shown to be required for proper cell surface expression of hδOR.

Tiivistelmä δ-opioidireseptori kuuluu G-proteiinikytkentäisiin reseptoreihin, ja sillä on tärkeä rooli kivun säätelyssä. Ihmisen δ-opioidireseptoria koodaavassa OPRD1 geenissä on havaittu ainakin…

Advisors/Committee Members: Petäjä-Repo, U. (Ulla).

Subjects/Keywords: ER quality control; ER-associated degradation; G protein-coupled receptor; N-linked glycosylation; SERCA; biosynthesis; endoplasmic reticulum; internalization; molecular chaperone; opioid receptor; polymorphism; G-proteiinikytkentäinen reseptori; N-glykosylaatio; SERCA; endoplasmakalvosto; endoplasmakalvoston laadunvalvonta; endoplasmakalvostoon kytkeytynyt proteiinihajotus; internalisaatio; molekulaarinen kaperoni; opioidireseptori; polymorfia

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Markkanen, P. (. (2012). Human δ opioid receptor:the effect of Phe27Cys polymorphism, N-linked glycosylation and SERCA2b interaction on receptor processing and trafficking. (Doctoral Dissertation). University of Oulu. Retrieved from http://urn.fi/urn:isbn:9789514298219

Chicago Manual of Style (16^th Edition):

Markkanen, P (Piia). “Human δ opioid receptor:the effect of Phe27Cys polymorphism, N-linked glycosylation and SERCA2b interaction on receptor processing and trafficking.” 2012. Doctoral Dissertation, University of Oulu. Accessed January 22, 2020. http://urn.fi/urn:isbn:9789514298219.

MLA Handbook (7^th Edition):

Markkanen, P (Piia). “Human δ opioid receptor:the effect of Phe27Cys polymorphism, N-linked glycosylation and SERCA2b interaction on receptor processing and trafficking.” 2012. Web. 22 Jan 2020.

Vancouver:

Markkanen P(. Human δ opioid receptor:the effect of Phe27Cys polymorphism, N-linked glycosylation and SERCA2b interaction on receptor processing and trafficking. [Internet] [Doctoral dissertation]. University of Oulu; 2012. [cited 2020 Jan 22]. Available from: http://urn.fi/urn:isbn:9789514298219.

Council of Science Editors:

Markkanen P(. Human δ opioid receptor:the effect of Phe27Cys polymorphism, N-linked glycosylation and SERCA2b interaction on receptor processing and trafficking. [Doctoral Dissertation]. University of Oulu; 2012. Available from: http://urn.fi/urn:isbn:9789514298219

Brno University of Technology

27. Götthans, Jakub. Problematika bezdrátových sítí .

Degree: 2012, Brno University of Technology

URL: http://hdl.handle.net/11012/9578

► Obsahem této práce je návrh a realizace bezdrátové sítě WLAN ve společnosti GK SERVIS, spol. s r.o. Navržená koncepce byla ověřena měřením funkčnosti, zabezpečení a… (more)

Subjects/Keywords: Bezdrátové sítě; bezdrátové připojení; Alohanet; CSMA; TDMA; FDMA; CDMA; GSM; Wi-Fi; WiMAX; IEEE 802.11a/b/g/n/ad; Mikrotik; Wireless networks; wireless connection; Alohanet; CSMA; TDMA; FDMA; CDMA; GSM; Wi-Fi; WiMAX; IEEE 802.11a/b/g/n/ad; Mikrotik

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Götthans, J. (2012). Problematika bezdrátových sítí . (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/9578

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Götthans, Jakub. “Problematika bezdrátových sítí .” 2012. Thesis, Brno University of Technology. Accessed January 22, 2020. http://hdl.handle.net/11012/9578.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Götthans, Jakub. “Problematika bezdrátových sítí .” 2012. Web. 22 Jan 2020.

Vancouver:

Götthans J. Problematika bezdrátových sítí . [Internet] [Thesis]. Brno University of Technology; 2012. [cited 2020 Jan 22]. Available from: http://hdl.handle.net/11012/9578.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Götthans J. Problematika bezdrátových sítí . [Thesis]. Brno University of Technology; 2012. Available from: http://hdl.handle.net/11012/9578

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Gouffé, Valérie. L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach.

Degree: Docteur es, Sciences de gestion, 2013, Pau

URL: http://www.theses.fr/2013PAUU2013

►

Avec les récentes réformes, dont la loi Hôpital, Patient, Santé et Territoires (HPST) de Juin 2009, l’hôpital s’est transformé non seulement dans sa forme organisationnelle… (more)

▼

Avec les récentes réformes, dont la loi Hôpital, Patient, Santé et Territoires (HPST) de Juin 2009, l’hôpital s’est transformé non seulement dans sa forme organisationnelle par la mise en oeuvre des pôles mais aussi dans son rapport à son environnement. Cette organisation polaire vise à rechercher une performance par une approche médico-économique. Ainsi les dispositifs de gestion ont été mis en place et cherchent à rendre compte de cette performance. Dans ce contexte, comment peuvent travailler des professionnels de champs aussi différents que celui de la gestion et celui du soin ? La gestion sous-entend une optimisation des moyens, alors que le service public défend en priorité des valeurs d’utilité sociale et d’attention aux usagers. Les acteurs du soin ont une forte identification professionnelle à cette mission d’utilité sociale. Dans ce travail, nous proposons d’identifier en quoi les décalages culturels au sein des pôles hospitaliers, participent à une perte de sens et de reconnaissance des agents à leur travail. Ces écarts culturels seront appréciés plus précisément au travers de l’appropriation des outils de gestion. Cette étude se base sur des entretiens réalisés au sein de différents hôpitaux (CHU et CH) et de secteur Médecine, Chirurgie, Obstétrique (MCO) et psychiatrie. Elle révèle lanécessité de pratiques managériales innovantes tournées notamment vers la gestion interculturelle afin que chaque acteur de ces nouvelles structures hospitalières se sente compris et intégré dans cette dynamique. L’étude proposée peut constituer un retour d’expérience intéressant pour mieux comprendre et améliorer l’utilisation des nouveaux outils de gestion. Des préconisations sont proposées et peuvent constituer des pistes de réflexion afin de répondre aux défis actuels de l’hôpital public.

With the latest reforms, among which the Hospital, Patient, Healthcare and Territory (HPST) Law, the French Hospital has changed not only the form of its organisation through the implementation of a polar organisation, but also its environmental concern. This polar organisation aims to strive for performance and efficiency via an managerial and medical approach. Thus, some management tools have been set up aimed in particular at giving feedback on such performance. In this context, how can professionals from such distinct fields as management and healthcare work? Management implies the optimization of resources when the public sector above all upholds values of social usefulness and patient care. Healthcare actors feel very much involved in this mission of social usefulness. In this work we propose to identify how cultural gaps within hospital poles contribute to a loss of meaning and acknowledgment among healthcare agents. Those cultural gaps will be examined more particularly through management tool appropriation. This study relies on interviews conducted in various healthcare facilities (PCO and psychiatric hospitals of various capacities such as CHU and CH). It reveals the need for innovative managerial practices, especially…

Advisors/Committee Members: Cargnello-Charles, Emmanuelle (thesis director).

Subjects/Keywords: Performance; Appropriation; Gestion; Interculturalité; P e r f o rma n c e; A p p r o p r i a t i o n ,; Ma n a g e me n t; I n t e r c u l t u r a l i sm

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gouffé, V. (2013). L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach. (Doctoral Dissertation). Pau. Retrieved from http://www.theses.fr/2013PAUU2013

Chicago Manual of Style (16^th Edition):

Gouffé, Valérie. “L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach.” 2013. Doctoral Dissertation, Pau. Accessed January 22, 2020. http://www.theses.fr/2013PAUU2013.

MLA Handbook (7^th Edition):

Gouffé, Valérie. “L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach.” 2013. Web. 22 Jan 2020.

Vancouver:

Gouffé V. L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach. [Internet] [Doctoral dissertation]. Pau; 2013. [cited 2020 Jan 22]. Available from: http://www.theses.fr/2013PAUU2013.

Council of Science Editors:

Gouffé V. L'appropriation des outils de gestion et performance hospitalière : pour une approche interculturelle : Management tool appropriation and hospital performance : towards an intercultural approach. [Doctoral Dissertation]. Pau; 2013. Available from: http://www.theses.fr/2013PAUU2013

Université du Québec à Montréal

29. Motoc, Claudiu Mircea. Algorithmes de recherche pour sélection de modèles.

Degree: 2011, Université du Québec à Montréal

URL: http://archipel.uqam.ca/4667/1/M12397.pdf

► Dans ce mémoire, nous nous intéressons à des algorithmes de sélection de modèles dans un contexte de régression linéaire et logistique. Nous expliquons premièrement les… (more)

Subjects/Keywords: Algorithme; Modèle statistique; Modélisation; Sélection; Leaps and Bounds (Algorithme); Occam's Window (Algorithme)

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Motoc, C. M. (2011). Algorithmes de recherche pour sélection de modèles. (Thesis). Université du Québec à Montréal. Retrieved from http://archipel.uqam.ca/4667/1/M12397.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Motoc, Claudiu Mircea. “Algorithmes de recherche pour sélection de modèles.” 2011. Thesis, Université du Québec à Montréal. Accessed January 22, 2020. http://archipel.uqam.ca/4667/1/M12397.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Motoc, Claudiu Mircea. “Algorithmes de recherche pour sélection de modèles.” 2011. Web. 22 Jan 2020.

Vancouver:

Motoc CM. Algorithmes de recherche pour sélection de modèles. [Internet] [Thesis]. Université du Québec à Montréal; 2011. [cited 2020 Jan 22]. Available from: http://archipel.uqam.ca/4667/1/M12397.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Motoc CM. Algorithmes de recherche pour sélection de modèles. [Thesis]. Université du Québec à Montréal; 2011. Available from: http://archipel.uqam.ca/4667/1/M12397.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Université du Québec à Montréal

30. Vouma Lekoundji, Jean-Baptiste. Modèles de Markov cachés.

Degree: 2014, Université du Québec à Montréal

URL: http://archipel.uqam.ca/7009/1/M13570.pdf

► Les modèles de Markov cachés (MMC) connaissent aujourd'hui un grand succès dans divers domaines d'application. Ils ont été initialement introduits dans la reconnaissance vocale par… (more)

▼ Les modèles de Markov cachés (MMC) connaissent aujourd'hui un grand succès dans divers domaines d'application. Ils ont été initialement introduits dans la reconnaissance vocale par Baker (1975) et Rabiner (1989), et plus tard dans des domaines tels que l'analyse de séquences biologiques par R. Durbin et Mitchison (1998), l'ingénierie financière par Weigend et Shi (1997) et bien d'autres. Ils sont utilisés pour modéliser des séquences d'observations qualitatives ou quantitatives. La plupart des méthodes d'utilisation et de développement des MMC ont été développées dans le cadre de la reconnaissance vocale. Par la suite ces mêmes techniques ont été appliquées et adaptées à d'autres domaines. Notre objectif dans ce mémoire est de présenter une vue d'ensemble de la théorie des MMC à temps discret. Nous exposons les trois problèmes classiques et développons différents algorithmes susceptibles de les résoudre en effectuant de l'inférence sur les états du processus. Les différents algorithmes dont nous traitons sont : l'algorithme Forward-Backward développé par Rabiner et Juang (1986) pour le problème d'évaluation de l'état le plus probable de générer une observation particulière, ou "symbole", à un certain instant défini (évaluation), l'algorithme de Viterbi (1967) pour le problème de calcul de la trajectoire d'états la plus probable de générer une séquence d'observations (décodage) et finalement l'algorithme de Baum-Welch traité par Baum et Eagon (1967) pour la construction d'un modèle adapté aux séquences d'états ou d'observations à modéliser (apprentissage). Nous illustrons ensuite ces algorithmes en les appliquants à des exemples plus démonstratifs. ______________________________________________________________________________ MOTS-CLÉS DE L’AUTEUR : États, séquences, symboles observables, processus de Markov à temps discret, MMC, algorithme Forward-Backward, algorithme de Viterbi, algorithme de Baulm-Welch, inférence.

Subjects/Keywords: Modèles de Markov cachés; Algorithme Forward-Backward; Algorithme de Viterbi; Algorithme de Baulm-Welch

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Vouma Lekoundji, J. (2014). Modèles de Markov cachés. (Thesis). Université du Québec à Montréal. Retrieved from http://archipel.uqam.ca/7009/1/M13570.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Vouma Lekoundji, Jean-Baptiste. “Modèles de Markov cachés.” 2014. Thesis, Université du Québec à Montréal. Accessed January 22, 2020. http://archipel.uqam.ca/7009/1/M13570.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Vouma Lekoundji, Jean-Baptiste. “Modèles de Markov cachés.” 2014. Web. 22 Jan 2020.

Vancouver:

Vouma Lekoundji J. Modèles de Markov cachés. [Internet] [Thesis]. Université du Québec à Montréal; 2014. [cited 2020 Jan 22]. Available from: http://archipel.uqam.ca/7009/1/M13570.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Vouma Lekoundji J. Modèles de Markov cachés. [Thesis]. Université du Québec à Montréal; 2014. Available from: http://archipel.uqam.ca/7009/1/M13570.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations