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Brno University of Technology
1.
Koštialik, Daniel.
Detekce chorob v snímku sítnice oka: Disease Detection in Eye Retina Image.
Degree: 2019, Brno University of Technology
URL: http://hdl.handle.net/11012/69662 
► Diabetic retinopathy and age related macular degeneration are among the most common eye retina diseases, which cause partial or complete blindness. The main goal of…
(more)
▼ Diabetic retinopathy and
age related macular degeneration are among the most common
eye retina diseases, which cause partial or complete blindness. The main goal of this thesis is to design and implement software for automatic detection of symptoms from
eye fundus images. The detection algorithm is based on the image segmentation by region growing method and afterwards analysis. Determination of retina objects such as optic disc, macula and blood vessels is important prior symptoms detection as they can adversely affect the results of the analysis. Total 259 images were analysed and algorithm reaches more than 90 % average success rate. The algorithm, in combination with appropriate hardware and optic mechanism, forms one of practical application in global population screening. Thanks the automatic detection it is possible to determine the presence of symptoms and start an early treatment.
Advisors/Committee Members: Maruniak, Lukáš (advisor), Semerád, Lukáš (referee).
Subjects/Keywords: sietnica oka; choroby oka; diabetická retinopatia; vekom podmienená makulárna degenerácia; spracovanie obrazu; OpenCV; C++; eye retina; eye disease; diabetic retinopathy; age related macular degeneration; image processing; OpenCV; C++
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APA (6th Edition):
Koštialik, D. (2019). Detekce chorob v snímku sítnice oka: Disease Detection in Eye Retina Image. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/69662
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Koštialik, Daniel. “Detekce chorob v snímku sítnice oka: Disease Detection in Eye Retina Image.” 2019. Thesis, Brno University of Technology. Accessed March 01, 2021.
http://hdl.handle.net/11012/69662.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Koštialik, Daniel. “Detekce chorob v snímku sítnice oka: Disease Detection in Eye Retina Image.” 2019. Web. 01 Mar 2021.
Vancouver:
Koštialik D. Detekce chorob v snímku sítnice oka: Disease Detection in Eye Retina Image. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11012/69662.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Koštialik D. Detekce chorob v snímku sítnice oka: Disease Detection in Eye Retina Image. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/69662
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
2.
Schweitzer, Cédric.
Analyse épidémiologique du glaucome dans une population âgée : l'étude ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et maladies Occulaires) : Epidemiology ou glaucoma in an elderly population : the Alienor Study.
Degree: Docteur es, Santé publique. Option : Epidémiologie, 2016, Bordeaux
URL: http://www.theses.fr/2016BORD0186
► Le glaucome est une maladie neurodégénérative qui se définit par une perte progressive en fibres nerveuses rétiniennes et un rétrécissement du champ visuel. Il s’agit…
(more)
▼ Le glaucome est une maladie neurodégénérative qui se définit par une perte progressive en fibres nerveuses rétiniennes et un rétrécissement du champ visuel. Il s’agit de la première cause de cécité irréversible dans le monde et le principal facteur de risque est la pression intraoculaire (PIO). L’étude ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et maladies OculaiRes) est une étude épidémiologique qui a pour but de déterminer l’incidence des différentes pathologies oculaires liées à l’âge avec les facteurs nutritionnels, démographiques ou environnementaux dans une population représentative de la région de Bordeaux. En 2009-2010, 624 sujets âgés de plus de 74 ans ont bénéficié d’un examen ophtalmologique complet incluant un examen du nerf optique en rétinophotographie et en tomographie à cohérence optique spectral-domain (SD-OCT), d’une mesure la PIO au tonomètre à air et d’une évaluation des propriétés biomécaniques de la cornée. Une mesure de l’accumulation cutanée de produits de glycation avancée a été réalisée par autofluorescence. Le diagnostic de glaucome a été réalisé en utilisant les critères de la classification ISGEO (International Society for Epidemiologic and Geographical Ophthalmology). Les paramètres biomécaniques de la cornée étaient modifiés avec l’âge et chez les sujets ayant une histoire résidentielle à des latitudes plus exposées aux ultraviolets ambiants. L’épaisseur de cornée était plus élevée chez les sujets anciennement fumeurs. L’autofluorescence cutanée ≥ 2.7 UA (Unité Arbitraire) était indépendamment associée au glaucome. Les paramètres d’épaisseur en fibres nerveuses rétiniennes du SD-OCT présentaient de bonnes performances diagnostiques pour discriminer les sujets glaucomateux des témoins et la base normative présentait de bonnes performances discriminatives lorsqu’au moins un des paramètres était considéré comme anormal. Notre étude apporte des résultats originaux en termes de facteurs de risque de glaucome ou de déterminants des facteurs de risque de glaucome. De plus les performances diagnostiques du SD-OCT pourraient fournir des informations utiles pour optimiser les stratégies de dépistage du glaucome dans une population générale âgée.
Glaucoma is a neurodegenerative disease defined by a progressive loss of optic nerve axons and retinal ganglion cells resulting in a characteristic enlargement of the optic nerve head cup and associated visual field defects. It remains the first cause of irreversible blindness worldwide and intraocular pressure (IOP) is the main risk factor. The ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et maladies OculaiRes) study is a population-based study. It aims to assess the associations of age-related eye diseases with nutritional, demographic and environmental factors in a representative population of the Bordeaux area. In 2009-2010, 624 subjects, aged 74 years or more, underwent a complete eye examination, including an optic nerve head evaluation using retinophotography and a spectral-domain optical coherence tomography (SD-OCT), an IOP…
Advisors/Committee Members: Delcourt, Cécile (thesis director).
Subjects/Keywords: Epidémiologie; Glaucome; Vieillissement oculaire; Dépistage glaucome; Biomécanique cornéenne; Produits de glycation avancée; Epidemiology; Glaucoma; Age-related eye disease; Glaucoma screening; Corneal biomechanics; Advanced glycation end-products
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APA (6th Edition):
Schweitzer, C. (2016). Analyse épidémiologique du glaucome dans une population âgée : l'étude ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et maladies Occulaires) : Epidemiology ou glaucoma in an elderly population : the Alienor Study. (Doctoral Dissertation). Bordeaux. Retrieved from http://www.theses.fr/2016BORD0186
Chicago Manual of Style (16th Edition):
Schweitzer, Cédric. “Analyse épidémiologique du glaucome dans une population âgée : l'étude ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et maladies Occulaires) : Epidemiology ou glaucoma in an elderly population : the Alienor Study.” 2016. Doctoral Dissertation, Bordeaux. Accessed March 01, 2021.
http://www.theses.fr/2016BORD0186.
MLA Handbook (7th Edition):
Schweitzer, Cédric. “Analyse épidémiologique du glaucome dans une population âgée : l'étude ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et maladies Occulaires) : Epidemiology ou glaucoma in an elderly population : the Alienor Study.” 2016. Web. 01 Mar 2021.
Vancouver:
Schweitzer C. Analyse épidémiologique du glaucome dans une population âgée : l'étude ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et maladies Occulaires) : Epidemiology ou glaucoma in an elderly population : the Alienor Study. [Internet] [Doctoral dissertation]. Bordeaux; 2016. [cited 2021 Mar 01].
Available from: http://www.theses.fr/2016BORD0186.
Council of Science Editors:
Schweitzer C. Analyse épidémiologique du glaucome dans une population âgée : l'étude ALIENOR (Antioxydants, Lipides Essentiels, Nutrition et maladies Occulaires) : Epidemiology ou glaucoma in an elderly population : the Alienor Study. [Doctoral Dissertation]. Bordeaux; 2016. Available from: http://www.theses.fr/2016BORD0186
University of Illinois – Chicago
3.
Parthasarathy, Rajni.
Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues.
Degree: 2015, University of Illinois – Chicago
URL: http://hdl.handle.net/10027/19762
► Amyloid-beta (Aβ), a 38-43 amino acid peptide generated in the eye and other tissues, has been hypothesized to exert toxic effects that contribute to the…
(more)
▼ Amyloid-beta (Aβ), a 38-43 amino acid peptide generated in the
eye and other tissues, has been hypothesized to exert toxic effects that contribute to the progression and pathology of
age-
related macular degeneration and other retinal degenerative diseases. My thesis study addresses the engineering of a treatment approach that enables the control of Aβ levels in the living
eye. Neprilysin (NEP), a native endopeptidase that cleaves Aβ into inactive products, is a membrane-anchored protein. However, the recombinant-catalytic domain of NEP (termed sNEP) is soluble and retains catalytic activity. We have investigated the ability of intravitreally injected sNEP to reduce, in vivo, ocular levels of Aβ40 and Aβ42, (40 and 42 amino acids respectively) two principal Aβ forms. Anesthetized 10-month wildtype (C57BL/6J) mice, and 2-3-month 5XFAD transgenic mice overexpressing human Aβ42, received intravitreal injections of phosphate-buffered saline (PBS) containing sNEP. Treated mice were maintained for varying periods. Harvested
eye tissues (combined lens, vitreous, retina, retinal pigment epithelium and choroid) were homogenized, extracted with PBS and analyzed for Aβ (ELISA) and protein (Bradford assay) to enable determinations of Aβ concentrations (pmol per g protein). Analytical procedures developed in the study included those for terminating sNEP activity prior to animal euthanasia, using the sNEP inhibitor phosphoramidon. sNEP activity remaining at defined post-sNEP-treatment times was analyzed by fluorometric assay. Retinal function in sNEP-treated eyes was analyzed by electroretinography (ERG). Key results obtained in the study include the following. (1) Untreated C57BL/6J eyes and 5XFAD eyes exhibit substantial Aβ levels. (2) Intravitreally delivered sNEP exhibits a concentration-dependent and time-dependent activity in reducing ocular Aβ levels. (3) Although sNEP is cleared rapidly from the
eye after delivery, Aβ levels remain low for up to several weeks. (4) As determined at a fixed time following sNEP treatment that substantially reduces Aβ, C57BL/6J and 5XFAD mouse eyes exhibit robust ERG responsiveness, indicating good tolerance of the
eye tissues to the sNEP treatment. Overall, the results of this study establish that sNEP delivery to the mouse
eye enables substantial in vivo reductions in Aβ levels. The data encourage further study of intravitreal sNEP treatment for investigational and, potentially, therapeutic applications.
Advisors/Committee Members: Pepperberg, David R. (advisor), Kay, Brian K. (committee member), Hetling, John R. (committee member), Eddington, David T. (committee member), Shahidi, Mahnaz (committee member).
Subjects/Keywords: Amyloid-beta; Neprilysin; Eye tissues; Age-related macular degeneration; mouse
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APA (6th Edition):
Parthasarathy, R. (2015). Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/19762
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Parthasarathy, Rajni. “Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues.” 2015. Thesis, University of Illinois – Chicago. Accessed March 01, 2021.
http://hdl.handle.net/10027/19762.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Parthasarathy, Rajni. “Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues.” 2015. Web. 01 Mar 2021.
Vancouver:
Parthasarathy R. Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues. [Internet] [Thesis]. University of Illinois – Chicago; 2015. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10027/19762.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Parthasarathy R. Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues. [Thesis]. University of Illinois – Chicago; 2015. Available from: http://hdl.handle.net/10027/19762
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Georgia State University
4.
Cheng, Qi.
Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008.
Degree: MPH, 2014, Georgia State University
URL: https://scholarworks.gsu.edu/iph_theses/344
► ABSTRACT IMPORTANCE: Age-related macular degeneration (AMD) is a leading cause of low vision in elderly population. The association of vascular and renal conditions has…
(more)
▼ ABSTRACT
IMPORTANCE:
Age-
related macular degeneration (AMD) is a leading cause of low vision in elderly population. The association of vascular and renal conditions has been reported inconsistently. Unfolding the association may provide the insight to
eye care providers to take account general health management into
eye care.
OBJECTIVES: To investigate the prevalence of the vascular and renal comorbidities with AMD, examine the association of a single or combination of these comorbidities with AMD.
DSIGN AND PARTICIPANTS: Population-base cross-sectional study involved the adults aged 40 years or older (N=4596) who participated in the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES), a national representative population-based survey of non-institutionalized US residents.
MAIN OUTCOMES AND MEASURES: AMD was defined by the presence of drusen and presence of pigmental abnormality. Angina pectoris (AP), coronary heart
disease (CHD), congestive heart failure (CHF) and myocardial infarction (MI), and stroke, assessed by self-report by the questionnaire of medical conditions, Chronic kidney
disease (CKD), assessed by self-report and estimation of glomerular filtration rate (GFR) and the level of urine albumin. Heart
disease (HD) was defined as having AP or CHF or CHD or MI.
RESULTS: Among individuals with AMD, 6% had AP, 10% had CHD, 7% had CHF, 10% had MI, 13% had stroke, and 29% had CKD. The weighted prevalence of these conditions were significantly higher than those without AMD (All P-values
CONCLUSION AND RELEVANCE: These findings from the nationally-representative sample of the US population highlight the prevalence of vascular and renal comorbidities associated with AMD, the modest evidence of relationship of each single comorbidity, and strong association of combination of stroke and CKD to AMD independent of
age, gender, and other factors. Because of the cross-sectional design, the results of this study can not address a causal relationship between AMD and the examined comorbidities. It is unclear whether AMD and comorbidities arise from individual predisposition to vascular and renal diseases or whether complications from these morbidities increase the risk of AMD. However, the important caveat is that preventive and care management for the examined comorbidities may lessen the severity of symptoms or prevent AMD.
Advisors/Committee Members: Richard Rothernberg MD, MPH, Jinan Saddine MD, MPH, Dora ll'yasova Ph.D.
Subjects/Keywords: Age-related macular degeneration; Comorbidities; Heart disease; Stroke; Chronic kidney disease
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APA ·
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APA (6th Edition):
Cheng, Q. (2014). Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/iph_theses/344
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cheng, Qi. “Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008.” 2014. Thesis, Georgia State University. Accessed March 01, 2021.
https://scholarworks.gsu.edu/iph_theses/344.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cheng, Qi. “Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008.” 2014. Web. 01 Mar 2021.
Vancouver:
Cheng Q. Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008. [Internet] [Thesis]. Georgia State University; 2014. [cited 2021 Mar 01].
Available from: https://scholarworks.gsu.edu/iph_theses/344.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cheng Q. Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008. [Thesis]. Georgia State University; 2014. Available from: https://scholarworks.gsu.edu/iph_theses/344
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Ottawa
5.
Abdualiyeva, Gulnara.
Employing mHealth Applications for the Self-Assessment of Selected Eye Functions and Prediction of Chronic Major Eye Diseases among the Aging Population
.
Degree: 2019, University of Ottawa
URL: http://hdl.handle.net/10393/39235
► In the epoch of advanced mHealth (mobile health) use in ophthalmology, there is a scientific call for regulating the validity and reliability of eye-related apps.…
(more)
▼ In the epoch of advanced mHealth (mobile health) use in ophthalmology, there is a scientific call for regulating the validity and reliability of eye-related apps. For a positive health outcome that works towards enhancing mobile-application guided diagnosis in joint decision-making between eye specialists and individuals, the aging population should be provided with a reliable and valid tool for assessment of their eye status outside the physician office. This interdisciplinary study aims to determine through hypothesis testing validity and reliability of a limited set of five mHealth apps (mHAs ) and through binary logistic regression the prediction possibilities of investigated apps to exclude the four major eye diseases in the particular demographic population.
The study showed that 189 aging adults (45- 86 years old) who did complete the mHAs’ tests were able to produce reliable results of selected eye function tests through four out of five mHAs measuring visual acuity, contrast sensitivity, red desaturation, visual field and Amsler grid in comparison with a “gold standard” - comprehensive eye examination. Also, part of the participants was surveyed for assessing the Quality of Experience on mobile apps.
Understanding of current reliability of existing eye-related mHAs will lead to the creation of ideal mobile application’ self-assessment protocol predicting the timely need for clinical assessment and treatment of age-related macular degeneration, diabetic retinopathy, glaucoma and cataract. Detecting the level of eye function impairments by mHAs is cost-effective and can contribute to research methodology in eye diseases’ prediction by expanding the system of clear criteria specially created for mobile applications and provide returning significant value in preventive ophthalmology.
Subjects/Keywords: mHealth applications;
Reliability;
Validity;
Age-related eye diseases;
Hypothesis testing;
Binary logistic regression
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APA ·
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APA (6th Edition):
Abdualiyeva, G. (2019). Employing mHealth Applications for the Self-Assessment of Selected Eye Functions and Prediction of Chronic Major Eye Diseases among the Aging Population
. (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/39235
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Abdualiyeva, Gulnara. “Employing mHealth Applications for the Self-Assessment of Selected Eye Functions and Prediction of Chronic Major Eye Diseases among the Aging Population
.” 2019. Thesis, University of Ottawa. Accessed March 01, 2021.
http://hdl.handle.net/10393/39235.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Abdualiyeva, Gulnara. “Employing mHealth Applications for the Self-Assessment of Selected Eye Functions and Prediction of Chronic Major Eye Diseases among the Aging Population
.” 2019. Web. 01 Mar 2021.
Vancouver:
Abdualiyeva G. Employing mHealth Applications for the Self-Assessment of Selected Eye Functions and Prediction of Chronic Major Eye Diseases among the Aging Population
. [Internet] [Thesis]. University of Ottawa; 2019. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10393/39235.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Abdualiyeva G. Employing mHealth Applications for the Self-Assessment of Selected Eye Functions and Prediction of Chronic Major Eye Diseases among the Aging Population
. [Thesis]. University of Ottawa; 2019. Available from: http://hdl.handle.net/10393/39235
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
6.
Dasari, Bhanu Chandar.
Cholesterol Dyshomeostasis And Age Related Macular Degeneration.
Degree: PhD, Biomedical Sciences, 2012, University of North Dakota
URL: https://commons.und.edu/theses/1235
► This dissertation work focused on retinal modifications that are relevant to Age-related macular degeneration (AMD) in cholesterol-fed rabbit model of Alzheimer's disease (AD), as…
(more)
▼ This dissertation work focused on retinal modifications that are relevant to
Age-
related macular degeneration (AMD) in cholesterol-fed rabbit model of Alzheimer's
disease (AD), as AD and AMD share common features. It is unknown whether cholesterol-fed rabbit model of AD displays any AMD features in retina. Previous research showed 27-hydroxycholesterol (27-OHC) involvement in AD like pathology in organotypic hippocampal slices of rabbit brain and human SHSY-5Y neuroblastoma cells. The extent to which and the mechanisms by which 27-OHC may also cause pathological hallmarks
related to AMD are not known. Various studies suggested estrogen's (E2) role in AMD development. 27-OHC is a ligand for estrogen receptor (ER) and liver X receptor (LXR). 25-hydroxycholesterol (25-OHC) and 7-ketocholesterol (7-KC) are also implicated in AMD development. 25-OHC and 7-KC were shown to be ligands of ER and LXR in various cell types. It is unknown whether 27-OHC, 25-OHC and 7-KC influence ER and LXR transcriptional activity in ARPE-19 cells, a spontaneously arising human RPE cell line with normal karyology.
ARPE-19 cells and cholesterol-fed rabbit eyes were used for the study. Paraffin embedded
eye cross sections were used for immunohistochemistry. Cholesterol was quantified by cholesterol/cholesteryl ester quantification kit. Oxysterols in the rabbit retinas were measured by mass spectrometry. Western blotting for detecting proteins, CytoTox-ONE homogenous membrane integrity
assay for measuring lactate dehydrogenase from cells, ELISA (Enzyme-linked immunosorbent assay) for quantifying amyloid beta 1-42 and 1-40, tumor necrosis factor alpha, DCFH-DA (2',7'-dichlorfluorescein-diacetate) assay for measuring reactive oxygen species (ROS), amplex red hydrogen peroxide / peroxidase assay for quantifying hydrogen peroxide and peroxidase activity, JC-1 (5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide) assay for mitochondrial membrane potential detection, TUNEL (Terminal deoxynucleotidyl transferase dUTP nick end labeling) assay for apoptotic cell detection, GSH-Glo assay for glutathione (GSH) quantification, calcium imaging, immunocytochemistry, immunohistochemistry and H&E (hematoxylin and eosin) staining, transfection and dual-luciferase reporter assays were used for this work.
This study showed retinal modifications that are relevant to AMD in cholesterol-fed rabbits. Increased abeta levels, decreased apoptosis regulator Bcl-2 levels, increased apoptosis regulator BAX and growth arrest and DNA damage-inducible protein GADD153 proteins, apoptotic cells, and increased generation of ROS were found in retinas from cholesterol-fed rabbit retinas. Furthermore, astrogliosis, drusen-like debris and cholesterol accumulations in retinas from cholesterol-fed rabbits were observed. Oxysterol levels in retinas from cholesterol-fed rabbits were increased. 27-OHC increased abeta peptide production, increased caspase 12 and GADD153, reduced mitochondrial membrane potential, triggered Ca2+ dyshomeostasis,…
Advisors/Committee Members: Othman Ghribi.
Subjects/Keywords: Age related macular degeneration; Alzheimer's disease; Cholesterol; nuclear receptor; Oxysterols; Retina
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APA ·
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Manager
APA (6th Edition):
Dasari, B. C. (2012). Cholesterol Dyshomeostasis And Age Related Macular Degeneration. (Doctoral Dissertation). University of North Dakota. Retrieved from https://commons.und.edu/theses/1235
Chicago Manual of Style (16th Edition):
Dasari, Bhanu Chandar. “Cholesterol Dyshomeostasis And Age Related Macular Degeneration.” 2012. Doctoral Dissertation, University of North Dakota. Accessed March 01, 2021.
https://commons.und.edu/theses/1235.
MLA Handbook (7th Edition):
Dasari, Bhanu Chandar. “Cholesterol Dyshomeostasis And Age Related Macular Degeneration.” 2012. Web. 01 Mar 2021.
Vancouver:
Dasari BC. Cholesterol Dyshomeostasis And Age Related Macular Degeneration. [Internet] [Doctoral dissertation]. University of North Dakota; 2012. [cited 2021 Mar 01].
Available from: https://commons.und.edu/theses/1235.
Council of Science Editors:
Dasari BC. Cholesterol Dyshomeostasis And Age Related Macular Degeneration. [Doctoral Dissertation]. University of North Dakota; 2012. Available from: https://commons.und.edu/theses/1235
University of Edinburgh
7.
Pead, Emma Jean Roberta.
Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging.
Degree: PhD, 2020, University of Edinburgh
URL: https://doi.org/10.7488/era/516
;
https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.814890
► The eye is embryologically, physiologically and anatomically linked to the brain. Emerging evidence suggests that neurodegenerative diseases, such as Alzheimer’s disease (AD), manifest in the…
(more)
▼ The eye is embryologically, physiologically and anatomically linked to the brain. Emerging evidence suggests that neurodegenerative diseases, such as Alzheimer’s disease (AD), manifest in the retina. Retinal imaging is a quick, non-invasive method to view the retina and its microvasculature. Features such as blood vessel calibre, tortuosity and complexity of the vascular structure (measured through fractal analysis) are thought to reflect microvascular health and have been found to associate with clinical signs of hypertension, diabetes, cardiovascular disease and cognitive decline. Small deposits of acellular debris called drusen in the peripheral retina have also been linked with AD where histological studies show they can contain amyloid beta, a hallmark of AD. Age-related macular degeneration (AMD) is a neurodegenerative disorder of the retina and a leading cause of irreversible vision loss in the ageing population. Increasing number and size of drusen is a characteristic of AMD disease progression. Ultra-widefield (UWF) retinal imaging with a scanning laser ophthalmoscope captures up to 80% of the retina in a single acquisition allowing a larger area of the retina to be assessed for signs of neurodegeneration than is possible with a conventional fundus camera, particularly the periphery. Quantification of changes to the microvasculature and drusen load could be used to derive early biomarkers of diseases that have vascular and neurodegenerative components such as AD and other forms of dementia. Manually grading drusen in UWF images is a difficult, subjective and a time-consuming process because the area imaged is large (around 700mm2) and drusen appear as small spots (< 125μm). An automatic approach to detecting drusen would overcome these challenges and facilitate investigations into drusen as a biomarker of neurodegeneration. In this thesis, an automatic system inspired by the recent successes of deep learning in medical image analysis was developed. As drusen are abundant in the retinas of people with AMD, a neural network was trained to classify patches in such a dataset of UWF images. This was compared to the manual gradings of two human observers. There was only a moderate agreement between observers (Kappa = 0.53, Average Dice Similarity Coefficient (DSC) = 0.38), reflecting the challenging and difficult nature of manually grading drusen in UWF images. Performances achieved for the automatic system (assessed using the area under curve (AUC) performance statistic) were 0.55-0.59, 0.62- 0.65 and 0.65-0.66 in the central, perimacular and peripheral regions of the retina, respectively. Highest performance was observed in a subset 8 images where observer agreement was at its highest (DSC > 0.8 and < 0.9), achieving AUC 0.55-0.59, 0.78-0.82 and 0.82-0.85 in the central, perimacular and peripheral zones, respectively. Measurements of the retinal vasculature appearing in UWF images of cognitively healthy (CH) individuals and patients diagnosed with mild cognitive impairment (MCI) and AD were obtained using a…
Subjects/Keywords: age-related macular degeneration; neurodegeneration; retinal imaging; Alzheimer's disease
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APA (6th Edition):
Pead, E. J. R. (2020). Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging. (Doctoral Dissertation). University of Edinburgh. Retrieved from https://doi.org/10.7488/era/516 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.814890
Chicago Manual of Style (16th Edition):
Pead, Emma Jean Roberta. “Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging.” 2020. Doctoral Dissertation, University of Edinburgh. Accessed March 01, 2021.
https://doi.org/10.7488/era/516 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.814890.
MLA Handbook (7th Edition):
Pead, Emma Jean Roberta. “Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging.” 2020. Web. 01 Mar 2021.
Vancouver:
Pead EJR. Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging. [Internet] [Doctoral dissertation]. University of Edinburgh; 2020. [cited 2021 Mar 01].
Available from: https://doi.org/10.7488/era/516 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.814890.
Council of Science Editors:
Pead EJR. Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging. [Doctoral Dissertation]. University of Edinburgh; 2020. Available from: https://doi.org/10.7488/era/516 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.814890
Macquarie University
8.
Gad, Nicholas Adam.
Human UV filters, UV light and oxidative damage in age related nuclear cataract: a thesis submitted in fulfilment of the requirements for the award of the degree of Doctor of Philosophy from Macquarie University.
Degree: 2016, Macquarie University
URL: http://hdl.handle.net/1959.14/1150567
► Empirical thesis.
Bibliography: pages 141-170.
Chapter 1. Introduction to human lens UV filters – Chapter 2. Identification of 3-hydroxykynurenine O-β-D glucoside derived novel UV filters…
(more)
▼ Empirical thesis.
Bibliography: pages 141-170.
Chapter 1. Introduction to human lens UV filters – Chapter 2. Identification of 3-hydroxykynurenine O-β-D glucoside derived novel UV filters – Chapter 3. UV irradiation of modified bovine lens proteins – Chapter 4. Analysis of lens proteins modified with kynurenine based human lens UV filters and metabolites – Chapter 5. Final conclusion and future directions.
Purpose: The lenses of humans contain a group of small protective molecules that are known as UV filters. The main UV filters present in human lenses are3-hydroxykynurenine O-β-D-glucoside (3OHKG), kynurenine (Kyn),3-hydroxykynurenine (3OHK) and 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid-O-β-D-glucoside (AHBG). These UV filters protect the lens from UV damage and it is believed that there may be other novel related species present in the lens that act analogously. The UV filters are also implicated in the progressive modification of lens proteins that occur with aging, and the development of age related nuclear cataract in older humans.
The first aim of this thesis was to detect, quantify and elucidate the structures of novel 3-hydroxykynurenine glucoside-derived UV filter metabolites present in the human lens. The second aim of this thesis was to investigate bovine lens proteins modified through covalent binding with UV filters and determine if these modified UV filter metabolites could be photosensitisers of oxidative damage. The final aim was to describe the detection and identification of amino acid residues involved in the covalent binding of human lens UV filters and metabolites to bovine lens proteins.
Methods: Three novel UV filter compounds 4-(2-amino-3-hydroxyphenyl)-2-hydroxy-4-oxobutanoic acid O-β-D-glucoside (3OHKG-W), 3-hydroxykynurenine O-β-Dglucosideyellow (3OHKG-Y) and 2-amino-3-hydroxyacetophenone O-β-D-glucoside (AHAG), along with Kyn, 3OHK, AHBG and 3OHKG, were detected and quantified by LC-MS/MS in 24 human lenses of different ages, of which 22 were normal and two had age related nuclear cataract. The structures of these compounds were confirmed through total synthesis and spectral analysis.
The synthesised analogues (3OHKG-Y, 3OHKG-W, AHAG), together with a previously identified analogue (3OHKG-D) and the major UV filters (3OHKG, Kyn,3OHK), were incubated with bovine lens proteins (BLP) at pH 7.4, to mimic physiological conditions, and at pH 9.5 (which accelerates deamination and encourages binding to protein residues). The modified lens proteins were exposed to UV light under aerobic and anaerobic conditions and in the presence and absence of free UV filters for varying periods of time. The UV light irradiated BLP were then separated through SDS-PAGE to observe protein binding, aggregation and any other observable changes.
Finally, the amino acid adducts produced from this incubation were identified by spectral analysis and identities confirmed by total synthesis. Their concentrations in the modified proteins were then quantified following enzymatic hydrolysis…
Advisors/Committee Members: Macquarie University. Department of Chemistry and Biomolecular Sciences.
Subjects/Keywords: Crystalline lens – Diseases; Cataract |x Age factors; Eye – Aging; UV filters; tryptophan; photoxidation; age related nuclear cataract
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APA (6th Edition):
Gad, N. A. (2016). Human UV filters, UV light and oxidative damage in age related nuclear cataract: a thesis submitted in fulfilment of the requirements for the award of the degree of Doctor of Philosophy from Macquarie University. (Doctoral Dissertation). Macquarie University. Retrieved from http://hdl.handle.net/1959.14/1150567
Chicago Manual of Style (16th Edition):
Gad, Nicholas Adam. “Human UV filters, UV light and oxidative damage in age related nuclear cataract: a thesis submitted in fulfilment of the requirements for the award of the degree of Doctor of Philosophy from Macquarie University.” 2016. Doctoral Dissertation, Macquarie University. Accessed March 01, 2021.
http://hdl.handle.net/1959.14/1150567.
MLA Handbook (7th Edition):
Gad, Nicholas Adam. “Human UV filters, UV light and oxidative damage in age related nuclear cataract: a thesis submitted in fulfilment of the requirements for the award of the degree of Doctor of Philosophy from Macquarie University.” 2016. Web. 01 Mar 2021.
Vancouver:
Gad NA. Human UV filters, UV light and oxidative damage in age related nuclear cataract: a thesis submitted in fulfilment of the requirements for the award of the degree of Doctor of Philosophy from Macquarie University. [Internet] [Doctoral dissertation]. Macquarie University; 2016. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1959.14/1150567.
Council of Science Editors:
Gad NA. Human UV filters, UV light and oxidative damage in age related nuclear cataract: a thesis submitted in fulfilment of the requirements for the award of the degree of Doctor of Philosophy from Macquarie University. [Doctoral Dissertation]. Macquarie University; 2016. Available from: http://hdl.handle.net/1959.14/1150567
Brno University of Technology
9.
Aubrecht, Tomáš.
Detekce onemocnění ve snímku sítnice oka: Illness Detection in Eye Retina Image.
Degree: 2019, Brno University of Technology
URL: http://hdl.handle.net/11012/85018
► Age-related macular degeneration is one of the most common retinal diseases of the human eye that leads at different rates to blindness. This disease occurs…
(more)
▼ Age-
related macular degeneration is one of the most common retinal diseases of the human
eye that leads at different rates to blindness. This
disease occurs in two forms. While the wet can slow down its progression, for dry form there is no available treatment method so far, so prevention is the most important. For this reason, the aim of this work is to design and implement software that allows automatic detection of the symptoms of this
disease from retinal images. The symptom detection algorithm is based on adaptive thresholding which obtains suspicious areas that are subsequently categorized. 407 retinal images were used for the evaluation and the software was highly successful. When used in conjunction with an optical retinal scanner, it helps ophthalmologists, for example, to diagnose more quickly.
Advisors/Committee Members: Semerád, Lukáš (advisor), Drahanský, Martin (referee).
Subjects/Keywords: lidské oko; sítnice oka; onemocnění oka; věkem podmíněná makulární degenerace; VPMD; C++; zpracování obrazu; OpenCV; human eye; eye retina; eye diseases; age-related macular degeneration; ARMD; C++; image processing; OpenCV
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APA (6th Edition):
Aubrecht, T. (2019). Detekce onemocnění ve snímku sítnice oka: Illness Detection in Eye Retina Image. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/85018
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Aubrecht, Tomáš. “Detekce onemocnění ve snímku sítnice oka: Illness Detection in Eye Retina Image.” 2019. Thesis, Brno University of Technology. Accessed March 01, 2021.
http://hdl.handle.net/11012/85018.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Aubrecht, Tomáš. “Detekce onemocnění ve snímku sítnice oka: Illness Detection in Eye Retina Image.” 2019. Web. 01 Mar 2021.
Vancouver:
Aubrecht T. Detekce onemocnění ve snímku sítnice oka: Illness Detection in Eye Retina Image. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11012/85018.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Aubrecht T. Detekce onemocnění ve snímku sítnice oka: Illness Detection in Eye Retina Image. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/85018
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
IUPUI
10.
Abootorabi, Seyedalireza.
Computational Fluid Dynamics for Modeling and Simulation of Intraocular Drug Delivery and Wall Shear Stress in Pulsatile Flow.
Degree: 2020, IUPUI
URL: http://hdl.handle.net/1805/23571
► Indiana University-Purdue University Indianapolis (IUPUI)
The thesis includes two application studies of computational fluid dynamics. The first is new and efficient drug delivery to the…
(more)
▼ Indiana University-Purdue University Indianapolis (IUPUI)
The thesis includes two application studies of computational
fluid dynamics. The first is new and efficient drug delivery to the posterior part of the eye, a growing health necessity worldwide. Current treatment of eye diseases, such as age-related macular degeneration (AMD), relies on repeated intravitreal injections of drug-containing solutions. Such a drug delivery has significant cant drawbacks, including short drug life, vital medical service, and high medical costs. In this study, we explore a new approach of controlled drug delivery by introducing unique porous implants. Computational modeling contains physiological and anatomical traits. We simulate the IgG1 Fab drug delivery to the posterior eye to evaluate the effectiveness of the porous implants to control the drug delivery. The computational model was validated by established computation results from independent studies and experimental data. Overall, the results indicate that therapeutic drug levels in the posterior eye are sustained for
eight weeks, similar to those performed with intravitreal injection of the same drug.
We evaluate the effects of the porous implant on the time evaluation of the drug
concentrations in the sclera, choroid, and retina layers of the eye. Subsequent simulations were carried out with varying porosity values of a porous episcleral implant.
Our computational results reveal that the time evolution of drug concentration is
distinctively correlated to drug source location and pore size. The response of this
porous implant for controlled drug delivery applications was examined. A correlation
between porosity and fluid properties for the porous implants was revealed in this
study. The second application lays in the computational modeling of the oscillating
Advisors/Committee Members: Yu, Huidan, Nematollahi, Khosrow, Yokota, Hiroki.
Subjects/Keywords: CFD; eye drug delivery; age-related macular degeneration; pulsatile flow; lattice Boltzmann method; wall shear stress
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APA ·
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APA (6th Edition):
Abootorabi, S. (2020). Computational Fluid Dynamics for Modeling and Simulation of Intraocular Drug Delivery and Wall Shear Stress in Pulsatile Flow. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/23571
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Abootorabi, Seyedalireza. “Computational Fluid Dynamics for Modeling and Simulation of Intraocular Drug Delivery and Wall Shear Stress in Pulsatile Flow.” 2020. Thesis, IUPUI. Accessed March 01, 2021.
http://hdl.handle.net/1805/23571.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Abootorabi, Seyedalireza. “Computational Fluid Dynamics for Modeling and Simulation of Intraocular Drug Delivery and Wall Shear Stress in Pulsatile Flow.” 2020. Web. 01 Mar 2021.
Vancouver:
Abootorabi S. Computational Fluid Dynamics for Modeling and Simulation of Intraocular Drug Delivery and Wall Shear Stress in Pulsatile Flow. [Internet] [Thesis]. IUPUI; 2020. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1805/23571.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Abootorabi S. Computational Fluid Dynamics for Modeling and Simulation of Intraocular Drug Delivery and Wall Shear Stress in Pulsatile Flow. [Thesis]. IUPUI; 2020. Available from: http://hdl.handle.net/1805/23571
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
11.
Merle, Benedicte.
Nutrition et dégénérescence maculaire liée a l’âge : approche épidémiologique du rôle des lipides : Nutrition and age macular degeneration : role of lipids with an epidemiological approach.
Degree: Docteur es, Sociétés, Politique, Santé publique. Santé Publique. Epidémiologie, 2012, Université de Bordeaux Segalen
URL: http://www.theses.fr/2012BOR21988
► La dégénérescence maculaire liée à l’âge (DMLA) représente actuellement la principale cause de cécité dans les pays industrialisés. Les traitements disponibles ne concernent qu’une partie…
(more)
▼ La dégénérescence maculaire liée à l’âge (DMLA) représente actuellement la principale cause de cécité dans les pays industrialisés. Les traitements disponibles ne concernent qu’une partie des cas (DMLA néovasculaire) et n’évitent pas toujours le développement de déficiences visuelles sévères. L’identification de facteurs modifiables, tels que la nutrition, pourrait représenter des moyens de prévention permettant de diminuer la fréquence de cette maladie handicapante dans nos populations. L’objectif de la thèse était d’étudier d’un point de vue épidémiologique, la relation entre nutrition et DMLA chez les 963 sujets de l’étude Aliénor (Antioxydants Lipides Essentiels Nutrition et maladies OculaiRes), âgés de 73 ans et plus, avec un intérêt particulier pour les lipides. La relation entre les lipides et la DMLA repose principalement sur la potentielle implication du métabolisme lipidique dans la physiopathologie de la DMLA, ainsi que sur le triple rôle structurel, fonctionnel et protecteur des acides gras polyinsaturés (AGPI) n-3 au sein de la rétine. Dans un premier temps, nous avons mis en évidence une diminution du risque de DMLA chez les sujets ayant des apports alimentaires élevés en AGPI n-3. L’estimation des apports alimentaires étant sujette à de nombreuses imperfections (déclaration des sujets, biais de mémorisation, imprécisions des tables de composition alimentaire…), nous avons ensuite utilisé un biomarqueur du statut en AGPI n-3 afin de s’affranchir de ces limites. Ce travail nous a permis de mettre en évidence une diminution du risque de DMLA prévalente et incidente chez les sujets ayant des niveaux plasmatiques élevés d’AGPI n-3. Enfin, nous avons étudié les relations de certains gènes impliqués dans le métabolisme lipidique avec DMLA, les niveaux de lipides sanguins et de xanthophylles. Il ressort que les sujets TT pour le polymorphisme du gène LIPC (rs493258) présentaient un risque diminué de DMLA ainsi que des niveaux plasmatiques de zéaxanthine plus élevés. Ces travaux viennent compléter et enrichir la littérature à ce sujet et apportent des arguments nouveaux quant au rôle des AGPI n-3 dans la rétine ; ils pourront également servir de support en matière de recommandations nutritionnelles et de prévention de la DMLA. Nos travaux sur l’implication des gènes du métabolisme des lipides soulèvent de nouvelles questions quant aux mécanismes impliqués dans cette pathologie et pourraient suggérer de nouvelles pistes de recherche thérapeutiques et préventives.
Age-related macular degeneration (AMD) is the leading cause of blindness in industrialized countries. Current treatments are limited to the neovascular form of the disease only and do not always prevent the development of severe visual impairment. The identification of modifiable risk factors, such as nutrition, may lead to preventive strategies, which may have the potential to reduce the impact and burden of AMD on the global aging population. The objective of the thesis was to study the association between nutrition and AMD in the 963 subjects,…
Advisors/Committee Members: Delcourt, Cécile (thesis director).
Subjects/Keywords: Epidémiologie; Vieillissement oculaire; Nutrition; Acides gras; Métabolisme lipidique; Epidemiology; Age-related eye diseases; Nutrition; Fatty acids; Lipid metabolism
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APA ·
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MLA ·
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Export
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APA (6th Edition):
Merle, B. (2012). Nutrition et dégénérescence maculaire liée a l’âge : approche épidémiologique du rôle des lipides : Nutrition and age macular degeneration : role of lipids with an epidemiological approach. (Doctoral Dissertation). Université de Bordeaux Segalen. Retrieved from http://www.theses.fr/2012BOR21988
Chicago Manual of Style (16th Edition):
Merle, Benedicte. “Nutrition et dégénérescence maculaire liée a l’âge : approche épidémiologique du rôle des lipides : Nutrition and age macular degeneration : role of lipids with an epidemiological approach.” 2012. Doctoral Dissertation, Université de Bordeaux Segalen. Accessed March 01, 2021.
http://www.theses.fr/2012BOR21988.
MLA Handbook (7th Edition):
Merle, Benedicte. “Nutrition et dégénérescence maculaire liée a l’âge : approche épidémiologique du rôle des lipides : Nutrition and age macular degeneration : role of lipids with an epidemiological approach.” 2012. Web. 01 Mar 2021.
Vancouver:
Merle B. Nutrition et dégénérescence maculaire liée a l’âge : approche épidémiologique du rôle des lipides : Nutrition and age macular degeneration : role of lipids with an epidemiological approach. [Internet] [Doctoral dissertation]. Université de Bordeaux Segalen; 2012. [cited 2021 Mar 01].
Available from: http://www.theses.fr/2012BOR21988.
Council of Science Editors:
Merle B. Nutrition et dégénérescence maculaire liée a l’âge : approche épidémiologique du rôle des lipides : Nutrition and age macular degeneration : role of lipids with an epidemiological approach. [Doctoral Dissertation]. Université de Bordeaux Segalen; 2012. Available from: http://www.theses.fr/2012BOR21988
Australian National University
12.
Fernando, Nilisha.
Macrophages, cytokines and complement as therapeutic targets in retinal degeneration
.
Degree: 2017, Australian National University
URL: http://hdl.handle.net/1885/132618
► Age-related macular degeneration (AMD) is the leading cause of blindness amongst the Western population, with an annual cost of 350 billion dollars worldwide. This disease…
(more)
▼ Age-related macular degeneration (AMD) is the leading cause of
blindness amongst the Western population, with an annual cost of
350 billion dollars worldwide. This disease affects a specialised
region in the central retina, the macula, where photoreceptors
and the retinal pigment epithelium (RPE) cells begin to
degenerate upon the onset of AMD. In the more prevalent atrophic
or ‘dry’ form of AMD, gradual photoreceptor and RPE cell
death leads to the formation of an expanding retinal lesion,
which causes irreversible blindness over time. Although AMD
pathogenesis involves multiple genetic and environmental factors,
it is well understood that inflammation is highly implicated in
disease progression. The recruitment of retinal microglia and
macrophages, the production of cytokines and chemokines, and the
deposition of complement system components are key features of
atrophic AMD.
This thesis identifies retinal microglia and macrophages as
therapeutic targets for slowing the progression of retinal
degenerations such as AMD. In these studies, a rodent model of
photo-oxidative damage is used, which recapitulates features of
atrophic AMD including oxidative stress, inflammation and
photoreceptor cell loss. This thesis first provides a further
understanding of the role of microglia and macrophages in
contributing to chronic complement activation and photoreceptor
death in the degenerating retina. It is shown that
locally-derived complement component 3 (C3) is a major
contributor to the progression of retinal degeneration, and that
microglia and macrophages are the primary source of retinal C3,
in both rodent retinal degeneration and human AMD.
The recruitment of microglia and macrophages in retinal diseases
is caused by increased chemokine signalling. It is demonstrated
in this thesis that the use of a broad spectrum chemokine
inhibitor (NR58-3.14.3) is able to ameliorate the accumulation of
microglia and macrophages in the outer retina, protecting the
photoreceptors from further damage. Finally, it is shown that
interleukin-1β (IL-1β), a strong pro-inflammatory cytokine, is
primarily produced by microglia and macrophages in retinal
degeneration. Using therapeutic strategies to neutralise or
inhibit IL-1β signalling, it is found that there is a decrease
in both macrophage recruitment and photoreceptor loss.
Collectively, these three studies implicate a major role for
retinal microglia and macrophages in contributing to
pro-inflammatory cytokine production and complement synthesis.
This thesis demonstrates the therapeutic value of targeting
microglia and macrophages as a strategy for reducing inflammation
and photoreceptor loss in retinal degenerations including AMD.
Subjects/Keywords: Retinal degeneration;
inflammation;
macrophage;
cytokine;
complement;
chemokine;
retina;
age-related macular degeneration;
innate immune system;
eye
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APA ·
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Manager
APA (6th Edition):
Fernando, N. (2017). Macrophages, cytokines and complement as therapeutic targets in retinal degeneration
. (Thesis). Australian National University. Retrieved from http://hdl.handle.net/1885/132618
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Fernando, Nilisha. “Macrophages, cytokines and complement as therapeutic targets in retinal degeneration
.” 2017. Thesis, Australian National University. Accessed March 01, 2021.
http://hdl.handle.net/1885/132618.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Fernando, Nilisha. “Macrophages, cytokines and complement as therapeutic targets in retinal degeneration
.” 2017. Web. 01 Mar 2021.
Vancouver:
Fernando N. Macrophages, cytokines and complement as therapeutic targets in retinal degeneration
. [Internet] [Thesis]. Australian National University; 2017. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1885/132618.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Fernando N. Macrophages, cytokines and complement as therapeutic targets in retinal degeneration
. [Thesis]. Australian National University; 2017. Available from: http://hdl.handle.net/1885/132618
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of New South Wales
13.
Sannapaneni, Krishnaiah.
Modeling the risks of age-related eye diseases in a population in South India.
Degree: Optometry & Vision Science, 2013, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/52892
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11570/SOURCE01?view=true
► The objective of this research was to determine whether an artificial intelligence methodology such as artificial neural network (ANN), a new type of predictive model…
(more)
▼ The objective of this research was to determine whether an artificial intelligence methodology such as artificial neural network (ANN), a new type of predictive model offers an increased performance over a conventional logistic regression model (LR) in predicting the ranking of risk factors for irreversible
age-
related chronic
eye diseases
age-
related macular degeneration (AMD), diabetic retinopathy (DR), primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) in a South Indian population. The LR and ANN models were derived and validated for their respective models predictive accuracy based on a sample (n=3,723) aged >=40 years old by using a large scale population-based epidemiologic study. Sub-population data were drawn from this sample by appropriate standard techniques that used for modeling. The LR based risk score models (RS) were derived and the model fit was assessed in a standard manner including the bootstrap method for internal validity. The ANN model was built by using the multi-layer feed-forward back propagation network. The ANN models predictive ability was compared with that of traditional model with respect to the Area under the Receiver Operating Characteristic Curve (AUROC). The sensitivity and specificity of the fitted models with a threshold criterion ranged from 70% to nearly 99% overall for all models. The ANN model outperformed the traditional LR model in a sub-population analysis in predicting AMD and DR. The predictive accuracy of ANN and LR model in predicting AMD was statistically significant (AUROC=89% vs 79%; p<0.0001). Both the models revealed that the modifiable risk factors such as heavy smoking (RS ranged from 10 to 18), lower intake of antioxidants (RS ranged from 5 to 10), hypertension (RS ranged from 2 to 10) were in order of priority predictors for AMD and longer duration of diabetes >=10 year (RS ranged from 29 to 42) was a highest priority predictor for DR. The modifiable risk factor intraocular pressure was in order of highest priority predictor for POAG and PACG. Population attributable risk percentage and population attributable fractions revealed that there is an urgent need of prioritizing modifying the modifiable factors as a public health approach. This was supported by a sensitivity analysis of the ANN model which indicated the relative importance of prioritizing modifiable risk factors on which to base preventive interventions to reduce the impact of onset or progression of these diseases.
Advisors/Committee Members: Keeffe, Jill, Honorary Professor, Department of Ophthalmology, University of Melbourne, VIC 8002, Australia, Gullapalli N, Rao, Chairman, L V Prasad Eye Institute, Banjara Hills, Hyderabad - 500034, India.
Subjects/Keywords: Statistical Model Validations; Neural Network Modeling; Ophthalmology; Epidemiologic Research; Population Attributable Risk; Irreversable Age-related Eye Diseases; South India
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APA (6th Edition):
Sannapaneni, K. (2013). Modeling the risks of age-related eye diseases in a population in South India. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/52892 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11570/SOURCE01?view=true
Chicago Manual of Style (16th Edition):
Sannapaneni, Krishnaiah. “Modeling the risks of age-related eye diseases in a population in South India.” 2013. Doctoral Dissertation, University of New South Wales. Accessed March 01, 2021.
http://handle.unsw.edu.au/1959.4/52892 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11570/SOURCE01?view=true.
MLA Handbook (7th Edition):
Sannapaneni, Krishnaiah. “Modeling the risks of age-related eye diseases in a population in South India.” 2013. Web. 01 Mar 2021.
Vancouver:
Sannapaneni K. Modeling the risks of age-related eye diseases in a population in South India. [Internet] [Doctoral dissertation]. University of New South Wales; 2013. [cited 2021 Mar 01].
Available from: http://handle.unsw.edu.au/1959.4/52892 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11570/SOURCE01?view=true.
Council of Science Editors:
Sannapaneni K. Modeling the risks of age-related eye diseases in a population in South India. [Doctoral Dissertation]. University of New South Wales; 2013. Available from: http://handle.unsw.edu.au/1959.4/52892 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:11570/SOURCE01?view=true
University of Exeter
14.
Hames, Thomas.
Investigating the role of epithelial-mesenchymal crosstalk in the pathology of idiopathic pulmonary fibrosis.
Degree: PhD, 2017, University of Exeter
URL: http://hdl.handle.net/10871/33142
► Idiopathic pulmonary fibrosis (IPF) is a disease of unknown aetiology, characterised by the progressive and irreversible scarring of parenchymal lung tissue that leads to respiratory…
(more)
▼ Idiopathic pulmonary fibrosis (IPF) is a disease of unknown aetiology, characterised by the progressive and irreversible scarring of parenchymal lung tissue that leads to respiratory failure and death. The disease is understood to be driven by an impaired and aberrant wound healing response, with an inappropriate reactivation of developmental signalling. The greatest risk factor for the disease is age, which is a process intimately associated with an increase in the burden of senescent cells. Such cells acquire a unique secretory phenotype and are known to have a significant impact on their local micro-environment. It was hypothesised that an alteration in epithelial-mesenchymal secretory communication, due to senescent-like changes in the fibroblast phenotype, may detrimentally contribute to lung homeostasis. An in vitro model of the lung airway was established in which primary human lung fibroblasts (HLFs) were co-cultured with human bronchial epithelial cells (HBECs). HBECs were cultured on a semi-permeable, transwell insert and co-cultured with either normal (NHLF), fibrotic (FHLF) or senescent fibroblasts. Over 72 hrs of co-culture, wound healing was assessed, via an epithelial scratch assay, and epithelial regeneration was measured, via trans-epithelial electrical resistance. Co-culture with NHLFs improves epithelial regeneration, however, FHLFs and senescent cells in co-culture show a diminished ability to promote epithelial regeneration and wound repair. The secretory repertoire of these cells contains elevated levels of IL-6, CXCL8, CXCL1 and GCSF (when assessed at both an RNA and protein level), factors strongly associated with the senescent phenotype. Targeting this secretome via treatment with the JAK 1/2 inhibitor Ruxolitinib attenuates these impairments and may point towards a new therapeutic strategy for the treatment of IPF.
Subjects/Keywords: 616.2; Idiopathic pulmonary fibrosis; senescence; epithelial-mesenchymal crosstalk; age-related disease; cell biology
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APA (6th Edition):
Hames, T. (2017). Investigating the role of epithelial-mesenchymal crosstalk in the pathology of idiopathic pulmonary fibrosis. (Doctoral Dissertation). University of Exeter. Retrieved from http://hdl.handle.net/10871/33142
Chicago Manual of Style (16th Edition):
Hames, Thomas. “Investigating the role of epithelial-mesenchymal crosstalk in the pathology of idiopathic pulmonary fibrosis.” 2017. Doctoral Dissertation, University of Exeter. Accessed March 01, 2021.
http://hdl.handle.net/10871/33142.
MLA Handbook (7th Edition):
Hames, Thomas. “Investigating the role of epithelial-mesenchymal crosstalk in the pathology of idiopathic pulmonary fibrosis.” 2017. Web. 01 Mar 2021.
Vancouver:
Hames T. Investigating the role of epithelial-mesenchymal crosstalk in the pathology of idiopathic pulmonary fibrosis. [Internet] [Doctoral dissertation]. University of Exeter; 2017. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10871/33142.
Council of Science Editors:
Hames T. Investigating the role of epithelial-mesenchymal crosstalk in the pathology of idiopathic pulmonary fibrosis. [Doctoral Dissertation]. University of Exeter; 2017. Available from: http://hdl.handle.net/10871/33142
Boston University
15.
Schu, Matthew Charles.
New methods for studying complex diseases via genetic association studies.
Degree: PhD, Bioinformatics, 2014, Boston University
URL: http://hdl.handle.net/2144/15117
► Genome-wide association studies (GWAS) have delivered many novel insights about the etiology of many common heritable diseases. However, in most disorders studied by GWAS, the…
(more)
▼ Genome-wide association studies (GWAS) have delivered many novel insights about the etiology of many common heritable diseases. However, in most disorders studied by GWAS, the known single nucleotide polymorphisms (SNPs) associated with the disease do not account for a large portion of the genetic factors underlying the condition. This suggests that many of the undiscovered variants contributing to the risk of common diseases have weak effects or are relatively rare. This thesis introduces novel adaptations of techniques for improving detection power for both of these types of risk variants, and reports the results of analyses applying these methods to real datasets for common diseases.
Chapter 2 describes a novel approach to improve the detection of weak-effect risk variants that is based on an adaptive sampling technique known as Distilled Sensing (DS). This procedure entails utilization of a portion of the total sample to exclude from consideration regions of the genome where there is no evidence of genetic association, and then testing for association with a greatly reduced number of variants in the remaining sample. Application of the method to simulated data sets and GWAS data from studies of age-related macular degeneration (AMD) demonstrated that, in many situations, DS can have superior power over traditional meta-analysis techniques to detect weak-effect loci.
Chapter 3 describes an innovative pipeline to screen for rare variants in next generation sequencing (NGS) data. Since rare variants, by definition, are likely to be present in only a few individuals even in large samples, efficient methods to screen for rare causal variants are critical for advancing the utility of NGS technology. Application of our approach, which uses family-based data to identify candidate rare variants that could explain aggregation of disease in some pedigrees, resulted in the discovery of novel protein-coding variants linked to increased risk for Alzheimer's disease (AD) in African Americans.
The techniques presented in this thesis address different aspects of the "missing heritability" problem and offer efficient approaches to discover novel risk variants, and thereby facilitate development of a more complete picture of genetic risk for common diseases.
Subjects/Keywords: Bioinformatics; Genetics; GWAS; Adaptive sampling; Age-related macular degeneration; Alzheimer's disease; Distilled sensing
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APA (6th Edition):
Schu, M. C. (2014). New methods for studying complex diseases via genetic association studies. (Doctoral Dissertation). Boston University. Retrieved from http://hdl.handle.net/2144/15117
Chicago Manual of Style (16th Edition):
Schu, Matthew Charles. “New methods for studying complex diseases via genetic association studies.” 2014. Doctoral Dissertation, Boston University. Accessed March 01, 2021.
http://hdl.handle.net/2144/15117.
MLA Handbook (7th Edition):
Schu, Matthew Charles. “New methods for studying complex diseases via genetic association studies.” 2014. Web. 01 Mar 2021.
Vancouver:
Schu MC. New methods for studying complex diseases via genetic association studies. [Internet] [Doctoral dissertation]. Boston University; 2014. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/2144/15117.
Council of Science Editors:
Schu MC. New methods for studying complex diseases via genetic association studies. [Doctoral Dissertation]. Boston University; 2014. Available from: http://hdl.handle.net/2144/15117
University of Melbourne
16.
CANTSILIERIS, STUART.
Investigation and assessment of copy number variation in Age-related Macular Degeneration.
Degree: 2013, University of Melbourne
URL: http://hdl.handle.net/11343/38343
► Age-related Macular Degeneration (AMD) is a common form of irreversible vision loss in Western populations. AMD is classified as a complex multi-factorial disease and is…
(more)
▼ Age-related Macular Degeneration (AMD) is a common form of irreversible vision loss in Western populations. AMD is classified as a complex multi-factorial disease and is associated with both genetic and environmental exposures. Despite intensive research efforts, the etiology of AMD remains incompletely understood. At the time of writing this thesis, AMD has been reported to be associated with 19 genetic loci, however, this has been reported to explain between 15-65% of the total genetic contribution to disease. Therefore a considerable amount of the “missing heritability” of AMD remains undiscovered.
Now that we have reached the post-GWAS era of AMD studies, there is a need to examine genetic variants that to date have been technically challenging to analyse. This includes the study of rare/private variants, and copy number variation. This thesis will focus on the analysis of copy number variation (CNV) and the contribution of CNVs to AMD susceptibility.
This doctoral work addresses some of the challenges involved for genotyping CNVs in association studies and applies several strategies to ensure reliable copy number typing. Using methods based on the Multiplex Ligation-dependent Amplification (MLPA) technique, the importance of ensuring reliable copy number measurement data is demonstrated. Additionally, I address potential outside influences such as differential bias, and implement statistical models that specifically take into account measurement error when performing tests for association.
This thesis provides further evidence for the contribution of CNVs to the “missing heritability” of AMD. These studies represent a candidate gene approach, predominantly focusing on the genes associated with complement regulation and activation. However, as demonstrated recently, several other biological pathways have been implicated in the etiology of AMD including lipid metabolism, angiogenesis and extracellular matrix degradation. Future studies of CNVs in AMD cohorts will likely benefit from a genome-wide analysis, potentially implementing next generation sequencing approaches to facilitate a better understanding of the overall contribution of CNVs to AMD susceptibility.
Subjects/Keywords: Age-related Macular Degeneration; copy number variation; complex disease; multiplex ligation-dependent probe amplification
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APA (6th Edition):
CANTSILIERIS, S. (2013). Investigation and assessment of copy number variation in Age-related Macular Degeneration. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38343
Chicago Manual of Style (16th Edition):
CANTSILIERIS, STUART. “Investigation and assessment of copy number variation in Age-related Macular Degeneration.” 2013. Doctoral Dissertation, University of Melbourne. Accessed March 01, 2021.
http://hdl.handle.net/11343/38343.
MLA Handbook (7th Edition):
CANTSILIERIS, STUART. “Investigation and assessment of copy number variation in Age-related Macular Degeneration.” 2013. Web. 01 Mar 2021.
Vancouver:
CANTSILIERIS S. Investigation and assessment of copy number variation in Age-related Macular Degeneration. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11343/38343.
Council of Science Editors:
CANTSILIERIS S. Investigation and assessment of copy number variation in Age-related Macular Degeneration. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/38343
University of Georgia
17.
Renzi, Lisa Marie.
Non-invasive assessment of retinal carotenoids as a biomarker of overall health status.
Degree: 2014, University of Georgia
URL: http://hdl.handle.net/10724/22768
► The purpose of this investigation was to examine the utility of measures of macular pigment optical density (MPOD) as a biomarker of systemic wellness. Forty-nine…
(more)
▼ The purpose of this investigation was to examine the utility of measures of macular pigment optical density (MPOD) as a biomarker of systemic wellness. Forty-nine individuals aged 24-76 from the Athens-Clarke County Community were selected
for participation. Serum lipid profiles, fasting glucose, anthropometric measures, and MPOD were measured, and information regarding smoking status and dietary intake of fruits and vegetables was collected. A positive association was detected between
MPOD measured at the one-degree and two-degree sites and balance time (r = 0.37, r = 0.41, respectively; p ” 0.05). In addition, a marginally significant inverse relation was detected between MPOD and serum triglycerides (r = -0.24, p ” 0.095). MPOD was
also significantly lower in smokers (t = -2.93, p ” 0.05). Significant relations were not detected between MPOD and any of the other wellness indices tested. Consequently, the utility of MPOD as a biomarker of overall wellness is questionable, although
MP may represent an independent proportion of variance for vision system health.
Subjects/Keywords: macular pigment; age-related macular degeneration; age-related cataract; heart disease; serum lipids; blood pressure; triglycerides; lipoproteins; ageing; macular pigment optical density; biomarker; wellness
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APA (6th Edition):
Renzi, L. M. (2014). Non-invasive assessment of retinal carotenoids as a biomarker of overall health status. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/22768
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Renzi, Lisa Marie. “Non-invasive assessment of retinal carotenoids as a biomarker of overall health status.” 2014. Thesis, University of Georgia. Accessed March 01, 2021.
http://hdl.handle.net/10724/22768.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Renzi, Lisa Marie. “Non-invasive assessment of retinal carotenoids as a biomarker of overall health status.” 2014. Web. 01 Mar 2021.
Vancouver:
Renzi LM. Non-invasive assessment of retinal carotenoids as a biomarker of overall health status. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10724/22768.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Renzi LM. Non-invasive assessment of retinal carotenoids as a biomarker of overall health status. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/22768
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
18.
Stanislovaitienė, Daiva.
Klinikinių veiksnių, oksidacinio streso žymens
N-karboksi(metil)lizino ir SCARB1 geno polimorfizmo sąsajos su
amžine geltonosios dėmės degeneracija ir išemine širdies
liga.
Degree: PhD, Medicine, 2014, Lithuanian Academic Libraries Network (LABT)
URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20140106_083847-47174
;
► Didėjant vyresnių žmonių populiacijai amžinė geltonosios dėmės degeneracija (AGDD) yra vis dažnesnė vyresnio nei 50 metų amžiaus žmonių negrįžtamo regos netekimo priežastis. AGDD prevencinės priemonės…
(more)
▼ Didėjant vyresnių žmonių populiacijai amžinė
geltonosios dėmės degeneracija (AGDD) yra vis dažnesnė vyresnio nei
50 metų amžiaus žmonių negrįžtamo regos netekimo priežastis. AGDD
prevencinės priemonės bei gydymo galimybės ribotos, nes ligos
etiopatogenezė iki šiol nėra visiškai aiški. Disertacinio darbo
metu įvertintos AGDD ir išeminės širdies ligos (IŠL) sąsajos,
atsižvelgiant į vainikinių arterijų aterosklerozinius pažeidimus.
Pirmą kartą analizuota SCARB1 rs5888 C/T genotipų įtaka AGDD ir IŠL
pasireiškimui. Tyrimo rezultatai parodė, kad AGDD ir IŠL, kai
vainikinėse arterijose yra aterosklerozinių pažeidimų (IŠLath+),
sieja bendri, šių ligų pasireiškimo galimybę didinantys,
klinikiniai veiksniai ir oksidacinis stresas. Nustatytas
„apsauginis“ SCARB1 rs5888 T/T genotipas, mažinantis AGDD ir
IŠLath+, bei „rizikingas“ SCARB1 rs5888 C/T genotipas, didinantis
AGDD+IŠLath+ galimybę. Pritaikius matematinės morfologijos metodus,
nustatyta, jog sergantiems vėlyvąja AGDD SCARB1 rs5888 „rizikingas“
genetinis variantas susijęs su didesniu centrinės tinklainės dalies
pažeidimo plotu. Bendrų AGDD ir IŠL patogenezinių grandžių tyrimas
suteikia naujos informacijos apie AGDD etiologiją, patogenezę ir
galbūt pasitarnaus efektyvaus gydymo bei prevencijos krypčių
kūrimui. Tyrimo metu taikyti morfometriniai geltonosios dėmės
pažaidos ploto matavimai gali būti naudojami gydytojų-oftalmologų
klinikinėje praktikoje, siekiant tiksliau įvertinti centrinės
tinklainės dalies pokyčius dinamikoje.
Age-related macular degeneration (ARMD) is
the commonest cause of blindness among persons over the age of 50
and its prevalence is likely to increase as a consequence of
population ageing. ARMD is a disorder of unknown cause and
pathogenesis, therefore current options for ARMD prevention and
treatment are limited. In the recent study the associations between
ARMD and CAD, according the angiographic findings of
atherosclerosis in the coronary arteries, were analyzed. The
oxidative stress impact and clinical factors determining
susceptibility to ARMD and CADath+, separately and common
susceptibility factors for both diseases prediction were
ascertained. Analysis of novel genetic biomarker, the rs5888
variant of SCARB1 gene, identified the „protective“ SCARB1 rs5888
TT genotype, associated with the lower risk of ARMD and CADath+,
and a „risk-determining“ CT genotype, determining higher
ARMD+CADath+ risk. The evaluation of macular lesion area by using
the methods of mathematical morphology revealed that in late stage
ARMD subjects carriers of SCARB1 rs5888 CT genotype the area of
macular lesion was larger than in TT genotype carriers. New
information about ARMD and CAD discovered additional knowledge
about ARMD etiopathogenesis and might be helpfull in search of new
treatments or strategies for ARMD prevention. Evaluation of macular
lesion area by mathematical morphology methods used in this study
may be useful in ophthalmological practice to monitor the dynamics
of ARMD.
Advisors/Committee Members: Žaliūnienė, Dalia (Doctoral dissertation supervisor), Lesauskaitė, Vaiva (Doctoral dissertation advisor), Ulozas, Virgilijus (Doctoral dissertation committee chair), Paunksnis, Alvydas (Doctoral dissertation committee member), Janulevičienė, Ingrida (Doctoral dissertation committee member), Kučinskienė, Zita Aušrelė (Doctoral dissertation committee member), Šerpytis, Pranas (Doctoral dissertation committee member), Ivanovienė, Laima (Doctoral dissertation opponent), Marinskis, Germanas (Doctoral dissertation opponent).
Subjects/Keywords: Amžinė geltonosios dėmės
degeneracija; Išeminė širdies
liga; SCARB1 genas; Age-related macular
degeneration; Coronary artery
disease; SCARB1 gene
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Stanislovaitienė, D. (2014). Klinikinių veiksnių, oksidacinio streso žymens
N-karboksi(metil)lizino ir SCARB1 geno polimorfizmo sąsajos su
amžine geltonosios dėmės degeneracija ir išemine širdies
liga. (Doctoral Dissertation). Lithuanian Academic Libraries Network (LABT). Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20140106_083847-47174 ;
Chicago Manual of Style (16th Edition):
Stanislovaitienė, Daiva. “Klinikinių veiksnių, oksidacinio streso žymens
N-karboksi(metil)lizino ir SCARB1 geno polimorfizmo sąsajos su
amžine geltonosios dėmės degeneracija ir išemine širdies
liga.” 2014. Doctoral Dissertation, Lithuanian Academic Libraries Network (LABT). Accessed March 01, 2021.
http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20140106_083847-47174 ;.
MLA Handbook (7th Edition):
Stanislovaitienė, Daiva. “Klinikinių veiksnių, oksidacinio streso žymens
N-karboksi(metil)lizino ir SCARB1 geno polimorfizmo sąsajos su
amžine geltonosios dėmės degeneracija ir išemine širdies
liga.” 2014. Web. 01 Mar 2021.
Vancouver:
Stanislovaitienė D. Klinikinių veiksnių, oksidacinio streso žymens
N-karboksi(metil)lizino ir SCARB1 geno polimorfizmo sąsajos su
amžine geltonosios dėmės degeneracija ir išemine širdies
liga. [Internet] [Doctoral dissertation]. Lithuanian Academic Libraries Network (LABT); 2014. [cited 2021 Mar 01].
Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20140106_083847-47174 ;.
Council of Science Editors:
Stanislovaitienė D. Klinikinių veiksnių, oksidacinio streso žymens
N-karboksi(metil)lizino ir SCARB1 geno polimorfizmo sąsajos su
amžine geltonosios dėmės degeneracija ir išemine širdies
liga. [Doctoral Dissertation]. Lithuanian Academic Libraries Network (LABT); 2014. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20140106_083847-47174 ;
19.
Liutkevičienė, Rasa.
Amžinės geltonosios dėmės degeneracijos ir
išeminės širdies ligos sąsajos su matrikso metaloproteinazių genų
polimorfizmu.
Degree: Dissertation, Medicine, 2011, Lithuanian Academic Libraries Network (LABT)
URL: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111220_141337-60930
;
► Darbo uždaviniai: 1. Nustatyti pradinės AGDD paplitimą vidutinio amžiaus (40 – 64 metų) pacientų, sergančių IŠL grupėje bei atsitiktinėje to paties amžiaus Kauno miesto gyventojų…
(more)
▼ Darbo uždaviniai: 1. Nustatyti pradinės AGDD
paplitimą vidutinio amžiaus (40 – 64 metų) pacientų, sergančių IŠL
grupėje bei atsitiktinėje to paties amžiaus Kauno miesto gyventojų
imtyje. 2. Palyginti pacientų, sergančių tik IŠL ir IŠL bei
pradinės AGDD klinikinius duomenis. 3. Nustatyti MMP-2 (-735 C/T),
MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) genotipų
dažnį bei genotipų derinių įtaką AGDD susiformavimui. 4. Nustatyti
MMP-2 (-735 C/T), MMP-2 (-1306 C/T), MMP-3 (-1171 5A/6A), MMP-9
(-1562 C/T) genotipų dažnį esant minkštoms ir kietoms drūzoms,
sergant AGDD. 5. Nustatyti MMP-2 (-735 C/T), MMP-2 (-1306 C/T),
MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T) genotipų dažnį bei genotipų
derinių įtaką AGDD ir IŠL drauge bei tik IŠL pasireiškimui. 6.
Nustatyti funkcinio kontrastinio jautrumo tyrimo rodmenis
pacientams, sergantiems pradine lengva ir pradine vidutine AGDD bei
spalvų juslės pokyčius sergantiems pradine AGDD, ir oftalmologiškai
sveikiems pacientams.
The goals were as follows: 1. To determine
the prevalence of AMD in patients with IHD and compare with the
prevalence in a random sample of Kaunas population (at 40-64 yrs
old). 2. To compare the main clinical characteristics of the
patients exhibiting early AMD and IHD together with the patients
with IHD alone. 3. To determine the frequency of the genotypes of
the matrix metalloproteinases (MMP-2 (-735 C/T), MMP-2 (-1306 C/T),
MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T)), and genotype combinations
that have an influence on the development of early AMD. 4. To
determine the frequency of the genotypes of the matrix
metallo¬proteinases (MMP-2 (-735 C/T), MMP-2 (-1306 C/T), MMP-3
(-1171 5A/6A), MMP-9 (-1562 C/T)), in early AMD patients with soft
or hard drusen. 5. To determine the frequency of the genotypes of
the matrix metallo¬proteinases (MMP-2 (-735 C/T), MMP-2 (-1306
C/T), MMP-3 (-1171 5A/6A), MMP-9 (-1562 C/T)), and the influence of
genotype combi¬na¬tions on the development of AMD and IHD together,
and only on IHD development. 6. To determine the results of
functional acuity contrast sensitivity test in patients with early
mild and early intermediate AMD, and color contrast sensitivity in
patients with AMD, and in ophthalmologically healthy
patients.
Advisors/Committee Members: Jašinskas, Vytautas (Doctoral dissertation supervisor), Lesauskaitė, Vaiva (Doctoral dissertation advisor), Ulozas, Virgilijus (Doctoral dissertation committee chair), Babarskienė, Marija Rūta (Doctoral dissertation committee member), Jankauskienė, Jūratė (Doctoral dissertation committee member), Tutkuvienė, Janina (Doctoral dissertation committee member), Paulauskas, Algimantas (Doctoral dissertation committee member), Paunksnis, Alvydas (Doctoral dissertation opponent), Marinskis, Germanas (Doctoral dissertation opponent).
Subjects/Keywords: Amžinė geltonosios dėmės
degeneracija; Išeminė širdies
liga; Matrikso
metaloproteinazė; Age-related macular
degeneration; Ischemic heart
disease; Matrix
metalloproteinases
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APA (6th Edition):
Liutkevičienė, R. (2011). Amžinės geltonosios dėmės degeneracijos ir
išeminės širdies ligos sąsajos su matrikso metaloproteinazių genų
polimorfizmu. (Doctoral Dissertation). Lithuanian Academic Libraries Network (LABT). Retrieved from http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111220_141337-60930 ;
Chicago Manual of Style (16th Edition):
Liutkevičienė, Rasa. “Amžinės geltonosios dėmės degeneracijos ir
išeminės širdies ligos sąsajos su matrikso metaloproteinazių genų
polimorfizmu.” 2011. Doctoral Dissertation, Lithuanian Academic Libraries Network (LABT). Accessed March 01, 2021.
http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111220_141337-60930 ;.
MLA Handbook (7th Edition):
Liutkevičienė, Rasa. “Amžinės geltonosios dėmės degeneracijos ir
išeminės širdies ligos sąsajos su matrikso metaloproteinazių genų
polimorfizmu.” 2011. Web. 01 Mar 2021.
Vancouver:
Liutkevičienė R. Amžinės geltonosios dėmės degeneracijos ir
išeminės širdies ligos sąsajos su matrikso metaloproteinazių genų
polimorfizmu. [Internet] [Doctoral dissertation]. Lithuanian Academic Libraries Network (LABT); 2011. [cited 2021 Mar 01].
Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111220_141337-60930 ;.
Council of Science Editors:
Liutkevičienė R. Amžinės geltonosios dėmės degeneracijos ir
išeminės širdies ligos sąsajos su matrikso metaloproteinazių genų
polimorfizmu. [Doctoral Dissertation]. Lithuanian Academic Libraries Network (LABT); 2011. Available from: http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20111220_141337-60930 ;
20.
Leeuwen, Redmer.
Age-related macular disease : studies on incidence, risk factors, and prognosis.
Degree: 2003, Erasmus University Medical Center
URL: http://hdl.handle.net/1765/31419
► textabstractAge-related macular disease (AMD) is a new name, recently coined by Bird,25 for a progressive and degenerative disease in elderly persons affecting the macula lutea.…
(more)
▼ textabstractAge-related macular disease (AMD) is a new name, recently coined by
Bird,25 for a progressive and degenerative disease in elderly persons
affecting the macula lutea. Dysfunction of this part of the retina, and
especially its centre, the fovea, results in the inability to read, recognize faces,
drive, and move freely.
Bird proposed to substitute the word disease for degeneration, probably
due to the pejorative ring of the latter and because the word degeneration does
not cover all pathological processes thought to play a role in AMD. According
to the current nomenclature of the International AMD Epidemiological Study
Group, all early and late signs of AMD are called age-related maculopathy
(ARM), while age-related macular degeneration indicates the two late stages of
ARM.24 These are the dry type, also called geographic atrophy, and the wet
type, also called neovascular or disciform AMD. The wet type often leads to
rapid loss of central vision while this may take years for the dry type.
The oldest image of disciform AMD, as far as we know, is from 1875
by Pagenstecher and Genth, while Haab was in 1885 the first to describe the
dry type of AMD that he called senile macular degeneration. I decided to
follow Bird’s example in the title of this thesis and used the word disease
instead of degeneration. However, the reader will find in the remainder of this
book the term ARM and AMD in the conventional sense, because most articles
included in the thesis were written at a time that we still used ARM as the
common denominator for this disease.
Subjects/Keywords: ARM; Age-related maculopathy; blindness; epidemiology; macular disease
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APA (6th Edition):
Leeuwen, R. (2003). Age-related macular disease : studies on incidence, risk factors, and prognosis. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/31419
Chicago Manual of Style (16th Edition):
Leeuwen, Redmer. “Age-related macular disease : studies on incidence, risk factors, and prognosis.” 2003. Doctoral Dissertation, Erasmus University Medical Center. Accessed March 01, 2021.
http://hdl.handle.net/1765/31419.
MLA Handbook (7th Edition):
Leeuwen, Redmer. “Age-related macular disease : studies on incidence, risk factors, and prognosis.” 2003. Web. 01 Mar 2021.
Vancouver:
Leeuwen R. Age-related macular disease : studies on incidence, risk factors, and prognosis. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2003. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/1765/31419.
Council of Science Editors:
Leeuwen R. Age-related macular disease : studies on incidence, risk factors, and prognosis. [Doctoral Dissertation]. Erasmus University Medical Center; 2003. Available from: http://hdl.handle.net/1765/31419
University of Melbourne
21.
WICKREMASINGHE, SANJEEWA.
Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration.
Degree: 2015, University of Melbourne
URL: http://hdl.handle.net/11343/55206
► This thesis describes the candidate’s part time work on a project at the Royal Victorian Eye and Ear Hospital and Centre for Eye Research Australia,…
(more)
▼ This thesis describes the candidate’s part time work on a project at the Royal Victorian Eye and Ear Hospital and Centre for Eye Research Australia, looking at the predictors of outcome following the use anti vascular endothelial growth factor agents in the treatment of neovascular age related macular degeneration.
The work from this thesis is part of the Predictors of outcome in age related macular degeneration study, which is an on-going project that is led by Professor Robyn Guymer (Candidate’s supervisor) looking at various factors that lead to suboptimal outcome in the treatment of neovascular age related macular degeneration, such as individual genetic make up and baseline clinical features.
Subjects/Keywords: neovascular age related macular degeneration
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APA (6th Edition):
WICKREMASINGHE, S. (2015). Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/55206
Chicago Manual of Style (16th Edition):
WICKREMASINGHE, SANJEEWA. “Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration.” 2015. Doctoral Dissertation, University of Melbourne. Accessed March 01, 2021.
http://hdl.handle.net/11343/55206.
MLA Handbook (7th Edition):
WICKREMASINGHE, SANJEEWA. “Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration.” 2015. Web. 01 Mar 2021.
Vancouver:
WICKREMASINGHE S. Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration. [Internet] [Doctoral dissertation]. University of Melbourne; 2015. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11343/55206.
Council of Science Editors:
WICKREMASINGHE S. Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration. [Doctoral Dissertation]. University of Melbourne; 2015. Available from: http://hdl.handle.net/11343/55206
22.
Gibert, Jorge C.
Distribution of Light in the Human Retina under Natural Viewing Conditions.
Degree: PhD, Physics, 2013, Florida International University
URL: https://digitalcommons.fiu.edu/etd/958
;
10.25148/etd.FI13112204
;
FI13112204
► Age-related macular degeneration (AMD) is the leading cause of blindness inAmerica. The fact that AMD wreaks most of the damage in the center of…
(more)
▼ Age-
related macular degeneration (AMD) is the leading cause of blindness inAmerica. The fact that AMD wreaks most of the damage in the center of the retina raises the question of whether light, integrated over long periods, is more concentrated in the macula.
A method, based on
eye-tracking, was developed to measure the distribution of light in the retina under natural viewing conditions. The hypothesis was that integrated over time, retinal illumination peaked in the macula. Additionally a possible relationship between
age and retinal illumination was investigated.
The
eye tracker superimposed the subject’s gaze position on a video recorded by a scene camera. Five informed subjects were employed in feasibility tests, and 58 naïve subjects participated in 5 phases. In phase 1 the subjects viewed a gray-scale image. In phase 2, they observed a sequence of photographic images. In phase 3 they viewed a video. In phase 4, they worked on a computer; in phase 5, the subjects walked around freely. The informed subjects were instructed to gaze at bright objects in the field of view and then at dark objects. Naïve subjects were allowed to gaze freely for all phases. Using the subject’s gaze coordinates, and the video provided by the scene camera, the cumulative light distribution on the retina was calculated for ~15° around the fovea.
As expected for control subjects, cumulative retinal light distributions peaked and dipped in the fovea when they gazed at bright or dark objects respectively. The light distribution maps obtained from the naïve subjects presented a tendency to peak in the macula for phases 1, 2, and 3, a consistent tendency in phase 4 and a variable tendency in phase 5.
The feasibility of using an
eye-tracker system to measure the distribution of light in the retina was demonstrated, thus helping to understand the role played by light exposure in the etiology of AMD. Results showed that a tendency for light to peak in the macula is a characteristic of some individuals and of certain tasks. In these situations, risk of AMD could be increased. No significant difference was observed based on
age.
Advisors/Committee Members: Richard A. Bone, Bernard S. Gerstman, John T. Landrum, Rajamani Narayanan.
Subjects/Keywords: retina; radiation damage; age-related macular degeneration; eye-tracker; Physics
…x29;.
1.4.1. Classification
The Age-Related Eye Disease Study (AREDS) (Age… …Related Eye Disease Research Study
Group 2000) classified AMD by the size and extent of… …9
1.4. Age-Related Macular Degeneration… …47
xii
1. INTRODUCTION
1.1. Motivation and Purpose
Age-related macular… …the
retina, which is the focus of this study.
1.4. Age-Related Macular Degeneration
Age…
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APA (6th Edition):
Gibert, J. C. (2013). Distribution of Light in the Human Retina under Natural Viewing Conditions. (Doctoral Dissertation). Florida International University. Retrieved from https://digitalcommons.fiu.edu/etd/958 ; 10.25148/etd.FI13112204 ; FI13112204
Chicago Manual of Style (16th Edition):
Gibert, Jorge C. “Distribution of Light in the Human Retina under Natural Viewing Conditions.” 2013. Doctoral Dissertation, Florida International University. Accessed March 01, 2021.
https://digitalcommons.fiu.edu/etd/958 ; 10.25148/etd.FI13112204 ; FI13112204.
MLA Handbook (7th Edition):
Gibert, Jorge C. “Distribution of Light in the Human Retina under Natural Viewing Conditions.” 2013. Web. 01 Mar 2021.
Vancouver:
Gibert JC. Distribution of Light in the Human Retina under Natural Viewing Conditions. [Internet] [Doctoral dissertation]. Florida International University; 2013. [cited 2021 Mar 01].
Available from: https://digitalcommons.fiu.edu/etd/958 ; 10.25148/etd.FI13112204 ; FI13112204.
Council of Science Editors:
Gibert JC. Distribution of Light in the Human Retina under Natural Viewing Conditions. [Doctoral Dissertation]. Florida International University; 2013. Available from: https://digitalcommons.fiu.edu/etd/958 ; 10.25148/etd.FI13112204 ; FI13112204
University of Melbourne
23.
Jeganathan, V. Swetha.
Retinal associations of diabetes and vascular disease.
Degree: 2009, University of Melbourne
URL: http://hdl.handle.net/11343/35293
► Background: Diabetes mellitus and vascular diseases have a significant impact on the eye. Aim: To determine the prevalence, risk factors, and racial/ethnic differences of major…
(more)
▼ Background: Diabetes mellitus and vascular diseases have a significant impact on the eye.
Aim: To determine the prevalence, risk factors, and racial/ethnic differences of major eye conditions, particularly retinal conditions, associated with diabetes and vascular diseases.
Scope: To date, the majority of studies have examined the association of retinal vascular calibre and diabetes in predominantly white Caucasian populations. Further elucidation of ethnic differences in effects of hyperglycaemia on early microvascular disease is relevant, particularly amongst Asians where diabetes is likely to see the largest increase in prevalence over the next decade. We therefore examined these findings from three Asian population-based studies, the Singapore Malay Eye Study (n=3280), Singapore Prospective Cohort Study and Singapore Cardiovascular Cohort Study 2 (n=3748).
Results: The prevalence of diabetic retinopathy in the Singapore Malay Eye Study was 35%, and associated with longer duration of diabetes, poorer glycemic and blood pressure control. More importantly, 9.0% had vision-threatening retinopathy, and retinopathy was found in 6.0% of people without diabetes. Retinal vascular calibre changes were incriminated in diseases such as diabetes and hypertension, independent of traditional cardiovascular risk factors. Wider venular calibre was independently associated with early age-related macular degeneration. We also found a novel association between peripheral artery disease and glaucoma, stronger in persons with diabetes, independent of vascular risk factors, supporting the vascular theory of glaucoma.
Implications: Subtle changes in retina, including retinal vascular calibre may be early markers of widespread microvascular changes in diabetes, resulting from chronic hyperglycaemia and other pathogenic processes. These results will have broad implications for understanding the impact of both microvascular and macrovascular complications of diabetes in the Asia Pacific region and targeting relevant therapeutic interventions.
Subjects/Keywords: diabetes; vascular disease; retinal changes; retinopathy; hyperglycaemia; retinal vascular calibre; glaucoma; age-related macular degeneration; Singapore Malay Eye Study; Singapore Prospective Cohort Study and Singapore Cardiovascular Cohort Study 2
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APA (6th Edition):
Jeganathan, V. S. (2009). Retinal associations of diabetes and vascular disease. (Masters Thesis). University of Melbourne. Retrieved from http://hdl.handle.net/11343/35293
Chicago Manual of Style (16th Edition):
Jeganathan, V Swetha. “Retinal associations of diabetes and vascular disease.” 2009. Masters Thesis, University of Melbourne. Accessed March 01, 2021.
http://hdl.handle.net/11343/35293.
MLA Handbook (7th Edition):
Jeganathan, V Swetha. “Retinal associations of diabetes and vascular disease.” 2009. Web. 01 Mar 2021.
Vancouver:
Jeganathan VS. Retinal associations of diabetes and vascular disease. [Internet] [Masters thesis]. University of Melbourne; 2009. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11343/35293.
Council of Science Editors:
Jeganathan VS. Retinal associations of diabetes and vascular disease. [Masters Thesis]. University of Melbourne; 2009. Available from: http://hdl.handle.net/11343/35293
University of Otago
24.
van Stockum, Eva Saskia.
Visual attention and eye movements in Parkinson's disease
.
Degree: 2012, University of Otago
URL: http://hdl.handle.net/10523/2137
► Saccades (fast eye movements) reveal the overt and covert deployment of visual attention, reflect more or less directly the influence of basal ganglia outputs, and…
(more)
▼ Saccades (fast
eye movements) reveal the overt and covert deployment of visual attention, reflect more or less directly the influence of basal ganglia outputs, and can be simply and accurately measured. Therefore, saccades are often used to study the effects of Parkinson’s
disease on the visual orienting system. This investigation attempts to resolve some apparent inconsistencies in the results of those studies.
Dopamine depletion in PD is thought to cause excessive inhibitory output from the basal ganglia to the visual orienting system and characteristic deficits in PD include prolonged saccade latencies and reduced saccade amplitude. In addition, there are reports of hyper-reflexivity and impaired suppression of unwanted
eye movements. Studies of visual attention in PD have reported evidence of overactive top-down response inhibition but also of abnormal facilitation of bottom-up attention. The generally accepted model assumes that abnormal bottom-up facilitation reflects a failure of top-down (cortical) control. This leaves the question: how or why does excessive inhibition co-occur with abnormal facilitation in the visual orienting system in PD?
The features of an existing experimental paradigm were exploited to measure top-down and bottom-up effects in the visual orienting system in a group of 20 subjects with Parkinson’s
disease and 20 control subjects. This specific paradigm (Deubel, 2008) combines saccades with a perceptual discrimination task. Our results suggest that Parkinson’s
disease may affect the visual orienting system globally, instead of affecting top-down response selection only. There were three ways in which the Parkinson’s
disease group differed from the control group. Firstly, the Parkinson’s
disease group made saccades that were abnormally hypometric. Secondly, saccade initiation in the Parkinson’s
disease group was hypersensitive to top-down facilitation in response to the demands of the discrimination task. Thirdly, saccade initiation in the Parkinson’s
disease group was hypersensitive to bottom-up facilitation by visual inputs.
These results were as expected, and confirmed previous findings. Interestingly, however, the observed effects did not necessarily co-occur in patients. In the Parkinson’s
disease group, patients with shorter mean saccade latencies had greater top-down facilitation and patients with longer mean saccade latencies had greater bottom-up facilitation. Abnormally reduced saccade gain was not associated with abnormal saccade latencies.
The Parkinson’s
disease group was also impaired in a set of neuropsychological tests compared to the control group. Cognitive problems were strongly associated with smaller mean saccade gain values, but also to some extent with longer mean saccade latencies and hyper-sensitivity to bottom-up visual inputs.
The discrimination task proved a valuable addition to standard saccade tasks. The finding that in the Parkinson’s
disease group, top-down and bottom-up effects were both exaggerated but not necessarily in the same subjects, may…
Advisors/Committee Members: Anderson, Timothy J (advisor).
Subjects/Keywords: Parkinson's disease;
eye movements
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APA (6th Edition):
van Stockum, E. S. (2012). Visual attention and eye movements in Parkinson's disease
. (Doctoral Dissertation). University of Otago. Retrieved from http://hdl.handle.net/10523/2137
Chicago Manual of Style (16th Edition):
van Stockum, Eva Saskia. “Visual attention and eye movements in Parkinson's disease
.” 2012. Doctoral Dissertation, University of Otago. Accessed March 01, 2021.
http://hdl.handle.net/10523/2137.
MLA Handbook (7th Edition):
van Stockum, Eva Saskia. “Visual attention and eye movements in Parkinson's disease
.” 2012. Web. 01 Mar 2021.
Vancouver:
van Stockum ES. Visual attention and eye movements in Parkinson's disease
. [Internet] [Doctoral dissertation]. University of Otago; 2012. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10523/2137.
Council of Science Editors:
van Stockum ES. Visual attention and eye movements in Parkinson's disease
. [Doctoral Dissertation]. University of Otago; 2012. Available from: http://hdl.handle.net/10523/2137
University of Ottawa
25.
Varin, Melanie.
Eye Disease and Cognition: A Canadian Hospital-Based Cross-Sectional Study
.
Degree: 2018, University of Ottawa
URL: http://hdl.handle.net/10393/37812
► Much attention is being expended to better understand the causes of cognitive impairment. The purpose of this thesis was to determine whether sensory deprivation, in…
(more)
▼ Much attention is being expended to better understand the causes of cognitive impairment. The purpose of this thesis was to determine whether sensory deprivation, in particular vision loss due to age-related eye disease, is related to cognitive function in older adults, and if so, why. The epidemiological evidence thus far is conflicting and has some limitations such as using cognitive tests that rely on vision or only using a single global cognitive test. This thesis examined the relationship between eye disease and cognition by using several cognitive tests that do not rely on vision and by studying vision loss due to two different eye diseases that are common in old age. Our hypothesis was that people with glaucoma or age-related macular degeneration (AMD) would have worse cognitive function on all six cognitive tests and that these relationships would be explained by their more limited involvement in cognitive activities. This work used baseline data from a 2-year prospective hospital-based cohort study of 235 older adults. We found that older adults with AMD and glaucoma participated in fewer activities at least once per month compared to older adults with normal vision after adjustment for demographic and health variables (β=-4.8, 95% CI= -6.8, -2.8) and (β=-2.6, 95% CI= -4.3, -0.9), respectively. Furthermore, we found that AMD was associated with lower verbal fluency letter scores (β=-2.2, 95% CI= -4.1, -0.3) while glaucoma was related to worse immediate and delayed recall of items on the logical memory story (β=-1.7, 95% CI= -3.1, -0.4) and (β=-1.5, 95% CI= -2.9, -0.1). These associations were all attenuated by the addition of cognitive activities to the models, which may indicate its role as a mediator. Longitudinal studies are needed to provide more rigorous evidence. If confirmed in prospective studies, efforts to improve cognitive activities and cognitive function could be targeted specifically at older adults with vision loss.
Subjects/Keywords: Eye disease;
Cognition;
Epidemiology
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APA (6th Edition):
Varin, M. (2018). Eye Disease and Cognition: A Canadian Hospital-Based Cross-Sectional Study
. (Thesis). University of Ottawa. Retrieved from http://hdl.handle.net/10393/37812
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Varin, Melanie. “Eye Disease and Cognition: A Canadian Hospital-Based Cross-Sectional Study
.” 2018. Thesis, University of Ottawa. Accessed March 01, 2021.
http://hdl.handle.net/10393/37812.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Varin, Melanie. “Eye Disease and Cognition: A Canadian Hospital-Based Cross-Sectional Study
.” 2018. Web. 01 Mar 2021.
Vancouver:
Varin M. Eye Disease and Cognition: A Canadian Hospital-Based Cross-Sectional Study
. [Internet] [Thesis]. University of Ottawa; 2018. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10393/37812.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Varin M. Eye Disease and Cognition: A Canadian Hospital-Based Cross-Sectional Study
. [Thesis]. University of Ottawa; 2018. Available from: http://hdl.handle.net/10393/37812
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Alberta
26.
Holly, Vanessa L.
Novel roles for zebrafish Sfrp1a and Sfrp5 in neural retina
patterning.
Degree: MS, Department of Biological Sciences, 2012, University of Alberta
URL: https://era.library.ualberta.ca/files/j098zc39w
► Sensory systems are complex structures that receive stimuli from the surrounding environment and convert them into interpretable information. In the visual system, light hitting the…
(more)
▼ Sensory systems are complex structures that receive
stimuli from the surrounding environment and convert them into
interpretable information. In the visual system, light hitting the
eye is transmitted to the brain in a way that preserves the spatial
conformation of the pictures we see. Retinal ganglion cells are
given directional cues of where to innervate the brain, based on
the unique cohort of genes activated during retinal development. If
there are alterations in gene expression, it can result in aberrant
axon projection to the brain and improper choroid fissure closure
(ocular coloboma). Using zebrafish as a model system, I demonstrate
that Sfrp1a (Secreted frizzled-related protein) and Sfrp5 work
cooperatively to establish dorsal retinal identity by facilitating
signaling from two well known dorsal retina specification pathways,
bone morphogenic protein (BMP) and Wnt. Previous experiments
identify Sfrps as BMP inhibitors, revealing a novel, positive
interaction between Sfrps and BMPs.
Subjects/Keywords: secreted frizzled-related protein; eye; retina; zebrafish
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Manager
APA (6th Edition):
Holly, V. L. (2012). Novel roles for zebrafish Sfrp1a and Sfrp5 in neural retina
patterning. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/j098zc39w
Chicago Manual of Style (16th Edition):
Holly, Vanessa L. “Novel roles for zebrafish Sfrp1a and Sfrp5 in neural retina
patterning.” 2012. Masters Thesis, University of Alberta. Accessed March 01, 2021.
https://era.library.ualberta.ca/files/j098zc39w.
MLA Handbook (7th Edition):
Holly, Vanessa L. “Novel roles for zebrafish Sfrp1a and Sfrp5 in neural retina
patterning.” 2012. Web. 01 Mar 2021.
Vancouver:
Holly VL. Novel roles for zebrafish Sfrp1a and Sfrp5 in neural retina
patterning. [Internet] [Masters thesis]. University of Alberta; 2012. [cited 2021 Mar 01].
Available from: https://era.library.ualberta.ca/files/j098zc39w.
Council of Science Editors:
Holly VL. Novel roles for zebrafish Sfrp1a and Sfrp5 in neural retina
patterning. [Masters Thesis]. University of Alberta; 2012. Available from: https://era.library.ualberta.ca/files/j098zc39w
Brno University of Technology
27.
Stančíková, Ivana.
Detekce a rozpoznání projevů onemocnění VPMD na sítnici lidského oka: Detection and Recognition of ARMD Disease Impacts to the Human Eye Retina.
Degree: 2019, Brno University of Technology
URL: http://hdl.handle.net/11012/180117
► This thesis aims to create a software able to detect symptoms of age-related macular degeneration in images of human eye retina. This condition is considered…
(more)
▼ This thesis aims to create a software able to detect symptoms of
age-
related macular degeneration in images of human
eye retina. This condition is considered one of the leading causes of vision loss in older adults. Lesions of the macular area called drusen are the first and also the most distinctive sign of developing ARMD. The approach presented in this thesis utilizes methods of image processing and computer vision to recognize retinal structures, in particular the optical disk and blood vessels, and distinguish between these structures and actual symptoms of the
disease. The evaluation of the program's success rate was performed on 692 images originating from four databases. The resulting solution has the potential to assist medical professionals with earlier diagnosis of the
disease and thus contribute to prevention of severe vision loss.
Advisors/Committee Members: Drahanský, Martin (advisor), Semerád, Lukáš (referee).
Subjects/Keywords: věkem podmíněná makulární degenerace; VPMD; lidské oko; sítnice; onemocnění oka; drúzy; detekce; zpracování obrazu; C++; OpenCV; age-related macular degeneration; ARMD; human eye; retina; eye diseases; drusen; detection; image processing; C++; OpenCV
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APA (6th Edition):
Stančíková, I. (2019). Detekce a rozpoznání projevů onemocnění VPMD na sítnici lidského oka: Detection and Recognition of ARMD Disease Impacts to the Human Eye Retina. (Thesis). Brno University of Technology. Retrieved from http://hdl.handle.net/11012/180117
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Stančíková, Ivana. “Detekce a rozpoznání projevů onemocnění VPMD na sítnici lidského oka: Detection and Recognition of ARMD Disease Impacts to the Human Eye Retina.” 2019. Thesis, Brno University of Technology. Accessed March 01, 2021.
http://hdl.handle.net/11012/180117.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Stančíková, Ivana. “Detekce a rozpoznání projevů onemocnění VPMD na sítnici lidského oka: Detection and Recognition of ARMD Disease Impacts to the Human Eye Retina.” 2019. Web. 01 Mar 2021.
Vancouver:
Stančíková I. Detekce a rozpoznání projevů onemocnění VPMD na sítnici lidského oka: Detection and Recognition of ARMD Disease Impacts to the Human Eye Retina. [Internet] [Thesis]. Brno University of Technology; 2019. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/11012/180117.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Stančíková I. Detekce a rozpoznání projevů onemocnění VPMD na sítnici lidského oka: Detection and Recognition of ARMD Disease Impacts to the Human Eye Retina. [Thesis]. Brno University of Technology; 2019. Available from: http://hdl.handle.net/11012/180117
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Johannesburg
28.
Moalusi, Sylvia Setlogano.
The relationship between autorefraction, retinoscopy and subjective refraction by age.
Degree: 2012, University of Johannesburg
URL: http://hdl.handle.net/10210/6490
► M.Phil.
The primary purpose of this study was to investigate in different age groups the various relationships between autorefraction and subjective refraction, between autorefraction and…
(more)
▼ M.Phil.
The primary purpose of this study was to investigate in different age groups the various relationships between autorefraction and subjective refraction, between autorefraction and retinoscopy and between retinoscopy and subjective refraction. Multivariate statistical methods are used to explore the nature of the relationships between these three different methods of evaluating refractive state. This is the first occasion in which these statistical approaches have been used to address these relationships within a sample of black South Africans. The short-term variation of measurements of the autorefractor used in this study was evaluated by means of an artificial or model eye. Here samples of fifty measurements each were obtained every two hours over a period of one day. Scatter plots, meridional profiles and hypothesis tests of equality of variance-covariance and of equality of mean autorefraction are used for analysis of the measurements obtained. Such analysis suggests that the variability in autorefraction across the day was of small magnitude and less than that typically found with human eyes. The implication is that many other factors besides the instrument itself are responsible for the variation found when using an autorefractor on a human eye. These factors include changes in accommodation, ocular fixation, the blinking process and attention. The environment within which the autorefractor is placed is important and changes in, for example, temperatur may have subtle but significant influences. The major part of this dissertation describes a study performed over a period of about seven months during which a sample of 240 male and female subjects were chosen randomly from a larger group of about 2800 patients who came to have their eyes examined in a clinical practice. A questionnaire was completed by each subject and retinoscopy was performed followed by subjective refraction and then autorefraction. Ocular health was assessed and visual acuities were measured. The study subjects were further divided into six smaller subgroups according to their ages and the analysis of results obtained with retinoscopy, subjective refraction and autorefraction included both qualitative and quantitative multivariate methods such as stereo-pair scatter plots, trajectories of change of dioptric power, meridional profiles, confidence and distribution ellipsoids, and testing of hypotheses of equality of variance-covariance and of equality of means. All of these methods help in understanding the nature of the various relationships between the different refractive methods, and they also are important when considering concepts such as mean refractive state and variation of refraction in human eyes. They also are used to develop an understanding of the distribution or spread of the population of refractive states from which the 'sample was obtained. For the three refractive methods . (retinoscopy, subjective refraction and autorefraction) the spread or distribution of measurements in the six age groups suggests that…
Subjects/Keywords: Eye - Accommodation and refraction - Age factors; Retinoscopy
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Record Details
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Moalusi, S. S. (2012). The relationship between autorefraction, retinoscopy and subjective refraction by age. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/6490
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Moalusi, Sylvia Setlogano. “The relationship between autorefraction, retinoscopy and subjective refraction by age.” 2012. Thesis, University of Johannesburg. Accessed March 01, 2021.
http://hdl.handle.net/10210/6490.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Moalusi, Sylvia Setlogano. “The relationship between autorefraction, retinoscopy and subjective refraction by age.” 2012. Web. 01 Mar 2021.
Vancouver:
Moalusi SS. The relationship between autorefraction, retinoscopy and subjective refraction by age. [Internet] [Thesis]. University of Johannesburg; 2012. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10210/6490.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Moalusi SS. The relationship between autorefraction, retinoscopy and subjective refraction by age. [Thesis]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/6490
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Johannesburg
29.
Joubert, Leoni.
The excess of automatic refraction over subjective refraction: dependence on age.
Degree: 2012, University of Johannesburg
URL: http://hdl.handle.net/10210/7607
► M.Phil.
Using newly developed statistical analysis methods for refractive error this study examines the difference between autorefraction and subjective refraction and how it is related…
(more)
▼ M.Phil.
Using newly developed statistical analysis methods for refractive error this study examines the difference between autorefraction and subjective refraction and how it is related to age. The term autorefractive excess refers to the amount obtained by subtracting the subjective refraction from the autorefraction. The clinical sample consisted of five groups of fifty subjects each. The subjects in group 1 ranged in age from 1 to 10 years, group 2 from 11 to 20 years, group 3 from 21 to 30 years, group 4 from 31 to 40 years and group 5 from 41 years and older. Only one examiner (the author) and one autorefractor (Allergan-Humphrey 580) were used. The study found that there was a difference between the mean autorefractive excesses for the different age groups and that the difference between autorefraction and subjective refraction was statistically significant in both the left and the right eyes of all age groups. Left and right eyes exhibited similar behavior. The autorefractive excess for both the left and the right eyes together of group 1 was approximately -0.25/-0.18 x180 in conventional and (-0.25 0.00 -0.43)' in h-notation. The autorefractive excess increases by approximately (0.10 0.00 0.10)' per decade. There is an astigmatic component of approximately -0.18 x180 in both eyes of all age groups. Approximately 60% of the subjects had sphere-equivalent strengths of autorefractive excesses of under 0.50 D. Therefore 60% of subjects might be content with a prescription given from the autorefractor reading. Approximately 50% of subjects had cylinderequivalent strengths of autorefractive excesses of under 0.50 D.
Subjects/Keywords: Eye – Accommodation and refraction – Age factors
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❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Joubert, L. (2012). The excess of automatic refraction over subjective refraction: dependence on age. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/7607
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Joubert, Leoni. “The excess of automatic refraction over subjective refraction: dependence on age.” 2012. Thesis, University of Johannesburg. Accessed March 01, 2021.
http://hdl.handle.net/10210/7607.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Joubert, Leoni. “The excess of automatic refraction over subjective refraction: dependence on age.” 2012. Web. 01 Mar 2021.
Vancouver:
Joubert L. The excess of automatic refraction over subjective refraction: dependence on age. [Internet] [Thesis]. University of Johannesburg; 2012. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10210/7607.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Joubert L. The excess of automatic refraction over subjective refraction: dependence on age. [Thesis]. University of Johannesburg; 2012. Available from: http://hdl.handle.net/10210/7607
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Johannesburg
30.
Richter, Susarah Maria.
Refractive status of children : intra-ocular variation and inter-ocular spread.
Degree: 2015, University of Johannesburg
URL: http://hdl.handle.net/10210/14597
► M.Phil.
The aim of this study was to use auto refraction to investigate both the short-term intra-ocular variation of refractive status among primary school children…
(more)
▼ M.Phil.
The aim of this study was to use auto refraction to investigate both the short-term intra-ocular variation of refractive status among primary school children and the spread of refractive status across eyes. The sample consisted of 90 Caucasian school children from a primary school in a small town, Eloff, in the Mpumalanga province of South Africa ...
Subjects/Keywords: Eye - Accommodation and refraction - Age factors
Record Details
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Record Details
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Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Richter, S. M. (2015). Refractive status of children : intra-ocular variation and inter-ocular spread. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/14597
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Richter, Susarah Maria. “Refractive status of children : intra-ocular variation and inter-ocular spread.” 2015. Thesis, University of Johannesburg. Accessed March 01, 2021.
http://hdl.handle.net/10210/14597.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Richter, Susarah Maria. “Refractive status of children : intra-ocular variation and inter-ocular spread.” 2015. Web. 01 Mar 2021.
Vancouver:
Richter SM. Refractive status of children : intra-ocular variation and inter-ocular spread. [Internet] [Thesis]. University of Johannesburg; 2015. [cited 2021 Mar 01].
Available from: http://hdl.handle.net/10210/14597.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Richter SM. Refractive status of children : intra-ocular variation and inter-ocular spread. [Thesis]. University of Johannesburg; 2015. Available from: http://hdl.handle.net/10210/14597
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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Open Access Theses and Dissertations
