subject:(Age Related Macular Degeneration)

University of Melbourne

1. WICKREMASINGHE, SANJEEWA. Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration.

Degree: 2015, University of Melbourne

URL: http://hdl.handle.net/11343/55206

► This thesis describes the candidate’s part time work on a project at the Royal Victorian Eye and Ear Hospital and Centre for Eye Research Australia,… (more)

Subjects/Keywords: neovascular age related macular degeneration

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APA (6^th Edition):

WICKREMASINGHE, S. (2015). Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/55206

Chicago Manual of Style (16^th Edition):

WICKREMASINGHE, SANJEEWA. “Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration.” 2015. Doctoral Dissertation, University of Melbourne. Accessed February 28, 2021. http://hdl.handle.net/11343/55206.

MLA Handbook (7^th Edition):

WICKREMASINGHE, SANJEEWA. “Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration.” 2015. Web. 28 Feb 2021.

Vancouver:

WICKREMASINGHE S. Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration. [Internet] [Doctoral dissertation]. University of Melbourne; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11343/55206.

Council of Science Editors:

WICKREMASINGHE S. Predictors of anti-vascular endothelial growth factor treatment response in neovascular age-related macular degeneration. [Doctoral Dissertation]. University of Melbourne; 2015. Available from: http://hdl.handle.net/11343/55206

University of Alberta

2. Dimopoulos, Ioannis. Electrophysiological and Genetic Aspects of Age-Related Macular Degeneration (AMD): Treatment Implications.

Degree: MS, Medical Sciences-Ophthalmology, 2014, University of Alberta

URL: https://era.library.ualberta.ca/files/r207tp55q

► Age-related macular degeneration (AMD) is considered a heterogeneous group of disorders. Although many genes influence susceptibility to disease, none has shown to be the primary… (more)

Subjects/Keywords: pharmacogenetics; genetics; age-related macular degeneration; electrophysiology

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APA (6^th Edition):

Dimopoulos, I. (2014). Electrophysiological and Genetic Aspects of Age-Related Macular Degeneration (AMD): Treatment Implications. (Masters Thesis). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/r207tp55q

Chicago Manual of Style (16^th Edition):

Dimopoulos, Ioannis. “Electrophysiological and Genetic Aspects of Age-Related Macular Degeneration (AMD): Treatment Implications.” 2014. Masters Thesis, University of Alberta. Accessed February 28, 2021. https://era.library.ualberta.ca/files/r207tp55q.

MLA Handbook (7^th Edition):

Dimopoulos, Ioannis. “Electrophysiological and Genetic Aspects of Age-Related Macular Degeneration (AMD): Treatment Implications.” 2014. Web. 28 Feb 2021.

Vancouver:

Dimopoulos I. Electrophysiological and Genetic Aspects of Age-Related Macular Degeneration (AMD): Treatment Implications. [Internet] [Masters thesis]. University of Alberta; 2014. [cited 2021 Feb 28]. Available from: https://era.library.ualberta.ca/files/r207tp55q.

Council of Science Editors:

Dimopoulos I. Electrophysiological and Genetic Aspects of Age-Related Macular Degeneration (AMD): Treatment Implications. [Masters Thesis]. University of Alberta; 2014. Available from: https://era.library.ualberta.ca/files/r207tp55q

Boston University

3. Akella, Sudheer. A novel association between serum bilirubin levels and age-related macular degeneration.

Degree: MS, Medical Sciences, 2014, Boston University

URL: http://hdl.handle.net/2144/14688

► The purpose of this study is to examine the association between serum bilirubin and the development of age-related macular degeneration (AMD). The study design includes… (more)

Subjects/Keywords: Ophthalmology; Age-related macular degeneration; AMD; Bilirubin

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APA (6^th Edition):

Akella, S. (2014). A novel association between serum bilirubin levels and age-related macular degeneration. (Masters Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/14688

Chicago Manual of Style (16^th Edition):

Akella, Sudheer. “A novel association between serum bilirubin levels and age-related macular degeneration.” 2014. Masters Thesis, Boston University. Accessed February 28, 2021. http://hdl.handle.net/2144/14688.

MLA Handbook (7^th Edition):

Akella, Sudheer. “A novel association between serum bilirubin levels and age-related macular degeneration.” 2014. Web. 28 Feb 2021.

Vancouver:

Akella S. A novel association between serum bilirubin levels and age-related macular degeneration. [Internet] [Masters thesis]. Boston University; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2144/14688.

Council of Science Editors:

Akella S. A novel association between serum bilirubin levels and age-related macular degeneration. [Masters Thesis]. Boston University; 2014. Available from: http://hdl.handle.net/2144/14688

University of Melbourne

4. Prea, Selwyn. Investing the laser-induced model of choroidal neovascularisation in Long Evans rats.

Degree: 2016, University of Melbourne

URL: http://hdl.handle.net/11343/91652

► Laser-induced choroidal neovascularisation (LI CNV) involves delivering laser energy to the retina to produce a breach in Bruch’s membrane (BM). Elevation of pro-angiogenic and inflammatory… (more)

Subjects/Keywords: choroidal neovascularisation; neovascular age-related macular degeneration

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APA (6^th Edition):

Prea, S. (2016). Investing the laser-induced model of choroidal neovascularisation in Long Evans rats. (Masters Thesis). University of Melbourne. Retrieved from http://hdl.handle.net/11343/91652

Chicago Manual of Style (16^th Edition):

Prea, Selwyn. “Investing the laser-induced model of choroidal neovascularisation in Long Evans rats.” 2016. Masters Thesis, University of Melbourne. Accessed February 28, 2021. http://hdl.handle.net/11343/91652.

MLA Handbook (7^th Edition):

Prea, Selwyn. “Investing the laser-induced model of choroidal neovascularisation in Long Evans rats.” 2016. Web. 28 Feb 2021.

Vancouver:

Prea S. Investing the laser-induced model of choroidal neovascularisation in Long Evans rats. [Internet] [Masters thesis]. University of Melbourne; 2016. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11343/91652.

Council of Science Editors:

Prea S. Investing the laser-induced model of choroidal neovascularisation in Long Evans rats. [Masters Thesis]. University of Melbourne; 2016. Available from: http://hdl.handle.net/11343/91652

University of Melbourne

5. Rose, Rose. Topographic rod function in intermediate age-related macular degeneration.

Degree: 2019, University of Melbourne

URL: http://hdl.handle.net/11343/225839

► Background Age-related macular degeneration (AMD) is a complex multifactorial disease that affects the elderly. In the early stages of disease, dark adaptation problems are more… (more)

▼ Background Age-related macular degeneration (AMD) is a complex multifactorial disease that affects the elderly. In the early stages of disease, dark adaptation problems are more significant for patients than visual acuity impairment. For decades, studies of rod function related to dark adaptation issues suggested that rod function could be useful as a functional marker for differentiating AMD severity and monitoring disease progression. However, there remains many unanswered questions about how best to investigate rod function in the early stages of AMD. Earlier studies were not able to phenotype AMD cases to the extent we can today as they relied only on colour fundus photographs to determine AMD subgroups. We now have the opportunity to look at different AMD phenotypes using multimodal imaging techniques. These advances have added clarity to the phenotyping of AMD, as high-risk features such as reticular pseudodrusen (RPD), hyperreflective foci (HRF), and nascent geographic atrophy (nGA) can now be identified. At the same time as the advances in detecting anatomical changes were made, instruments that could measure rod function in a more thorough way were improving. Previously, instruments measured rod function at only a single retinal location, or could only detect large losses in sensitivity due to a lack of dynamic range. Recent advances have seen perimeters that are able to measure rod function at multiple locations in the one setting and also have a larger dynamic range to detect subtle rod dysfunction. I have used one of these new tools in my studies. Aims Two-color dark-adapted chromatic perimeter (DACP) is a novel device, designed and manufactured in Melbourne, Australia. It was first used in 2015 when I commenced my PhD. This perimeter measures rod function at multiple locations with sufficiently large range of stimulus intensities to detect subtle changes seen in early AMD. My thesis aimed to investigate the ability of the DACP to reliably detect and record rod sensitivities. I then utilized this new perimeter to investigate the ability of rod function to act as a robust functional biomarker that could be used to determine AMD disease severity and to monitor disease progression, and to compare rod function in AMD cases to normal control participants. I was also able to separate my AMD cohort into those with or without RPD, a high-risk AMD phenotype, to investigate the impact of this phenotype on rod function. Both static and dynamic rod functional changes were recorded at baseline visits and then again at 6- and 12-months. The results of this study will contribute to our understanding of functional loss in AMD and help clinicians and researchers when designing research protocols aiming to evaluate rod functional impairment before vision loss. Methods This study was conducted between 2015 and 2018 at the Macular Research Unit, Centre for Eye Research Australia. During that time, three main studies were completed. An initial assessment of test-retest reliability of the DACP was followed…

Subjects/Keywords: rod function; age-related macular degeneration

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APA (6^th Edition):

Rose, R. (2019). Topographic rod function in intermediate age-related macular degeneration. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/225839

Chicago Manual of Style (16^th Edition):

Rose, Rose. “Topographic rod function in intermediate age-related macular degeneration.” 2019. Doctoral Dissertation, University of Melbourne. Accessed February 28, 2021. http://hdl.handle.net/11343/225839.

MLA Handbook (7^th Edition):

Rose, Rose. “Topographic rod function in intermediate age-related macular degeneration.” 2019. Web. 28 Feb 2021.

Vancouver:

Rose R. Topographic rod function in intermediate age-related macular degeneration. [Internet] [Doctoral dissertation]. University of Melbourne; 2019. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11343/225839.

Council of Science Editors:

Rose R. Topographic rod function in intermediate age-related macular degeneration. [Doctoral Dissertation]. University of Melbourne; 2019. Available from: http://hdl.handle.net/11343/225839

University of Edinburgh

6. Stanton, Chloe May. Investigating the genetic and molecular basis of age-related macular degeneration.

Degree: PhD, 2012, University of Edinburgh

URL: http://hdl.handle.net/1842/9608

► Age-related macular degeneration (AMD) is the leading cause of blindness worldwide, affecting an estimated 50 million individuals aged over 65 years. Environmental and genetic risk-factors… (more)

▼ Age-related macular degeneration (AMD) is the leading cause of blindness worldwide, affecting an estimated 50 million individuals aged over 65 years. Environmental and genetic risk-factors contribute to the development of AMD. An AMD-risk locus on chromosome 10q26 spans two genes, ARMS2 and HTRA1, and controversy exists as to which variants are responsible for increased risk of disease. Recent work suggests that HTRA1 expression levels are significantly increased in carriers of the risk haplotype associated with AMD. However, relatively little is known about the interactions, substrate specificity and roles in disease played by this secreted serine protease. This thesis aims to elucidate the potential role played by HTRA1 in AMD pathogenesis. A combination of tandem affinity purification (TAP) and yeast two-hybrid techniques was used to identify interacting partners of HTRA1. A number of proteins, with diverse roles in the alternative complement pathway, cell signaling, cell-matrix interactions, inflammation, angiogenesis and fibrosis, were identified. These are attractive candidates for further study as such processes are disturbed in AMD, implicating HTRA1 and its binding partners in disease development. One interacting partner, Complement Factor D (CFD), is a key activator in the alternative complement pathway. CFD, a 24 kDa serine protease, is expressed as an inactive zymogen, from which a signal peptide and activation peptide are cleaved before release of the mature, active protein into the circulation. In vitro studies show that CFD interacts with, and can be a substrate for, HTRA1. The interacting domain between the two proteins is localised to a region of 30 amino acids at the N-terminal end of proCFD. The 5 amino acid pro-peptide of CFD appears to be both necessary and sufficient for proteolysis of CFD by HTRA1. Investigation of the functional relevance of the interaction between HTRA1 and CFD shows that proCFD is cleaved by HTRA1, whilst mature CFD is not subjected to proteolysis. HTRA1-mediated cleavage of CFD forms an active protease, leading to activation of factor B in the alternative complement pathway in in vitro assays. Furthermore, a normal complement response is restored to CFD-depleted serum by addition of proCFD activated by HTRA1. Thus, an HTRA1- mediated increase in alternative complement pathway activity may explain a proportion of the AMD-risk attributed to the chr10q26 locus. Genetic and protein-based approaches were used to study the potential role of CFD in AMD pathogenesis, independent of an interaction with HTRA1. An intronic SNP, rs3826945, was significantly associated with increased risk of AMD in two British case-control cohorts, and in a combined meta-analysis with 4 additional cohorts from North America and Europe (p-value = 0.032, Odds Ratio = 1.112 in 4765 cases and 2693 controls). Assessment of copy number variation and sequencing of CFD did not identify any functional variants which may explain the association with disease. However, plasma levels of CFD were measured by ELISA in…

Subjects/Keywords: 617.7; Age-related macular degeneration; AMD; HTRA1

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APA (6^th Edition):

Stanton, C. M. (2012). Investigating the genetic and molecular basis of age-related macular degeneration. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/9608

Chicago Manual of Style (16^th Edition):

Stanton, Chloe May. “Investigating the genetic and molecular basis of age-related macular degeneration.” 2012. Doctoral Dissertation, University of Edinburgh. Accessed February 28, 2021. http://hdl.handle.net/1842/9608.

MLA Handbook (7^th Edition):

Stanton, Chloe May. “Investigating the genetic and molecular basis of age-related macular degeneration.” 2012. Web. 28 Feb 2021.

Vancouver:

Stanton CM. Investigating the genetic and molecular basis of age-related macular degeneration. [Internet] [Doctoral dissertation]. University of Edinburgh; 2012. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1842/9608.

Council of Science Editors:

Stanton CM. Investigating the genetic and molecular basis of age-related macular degeneration. [Doctoral Dissertation]. University of Edinburgh; 2012. Available from: http://hdl.handle.net/1842/9608

University of Sydney

7. Broadhead, Geoffrey Kenneth. Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration .

Degree: 2015, University of Sydney

URL: http://hdl.handle.net/2123/14720

► Purpose: To assess the efficacy of two therapies, intravitreal aflibercept and oral saffron supplementation, for the treatment of different aspects of age-related macular degeneration (AMD).… (more)

▼ Purpose: To assess the efficacy of two therapies, intravitreal aflibercept and oral saffron supplementation, for the treatment of different aspects of age-related macular degeneration (AMD). Methods: Two prospective clinical trials were conducted, i) one open label, single arm trial investigating intravitreal aflibercept for the management of treatment-resistant neovascular AMD, and ii) the other a randomised control trial investigating oral saffron supplementation for the treatment of intermediate AMD. Outcomes assessed included: mean change in mfERG response, mean change in individual mfERG ring response, mean change in BCVA and safety of saffron as compared to placebo. Results: i) The mean gain in BCVA was 6.7 and 4.7 letters at 6 and 12 months respectively (p<0.001), and the mean reduction in CMT was 100.0 µm at 6 and 12 months respectively. ii) Saffron supplementation was associated with a 2.1% increase in overall mfERG response (p=0.08) and a 0.69 letter increase in BCVA (p=0.001) compared to placebo. In those patients on AREDS supplements, saffron was associated with an increase of 2.8% in mfERG and an increase in BCVA of 0.73 letters (p<0.05 for both). There was no significant difference in adverse event frequency (overall or by subtype) whilst on saffron as compared to placebo. Conclusions: i) Intravitreal aflibercept was an effective therapy for the management of treatment-resistant neovascular AMD. The efficacy of aflibercept waned slightly over time, and further research is needed on the long-term effects of anti-VEGF agents. ii) Oral saffron was effective in improving visual outcomes in patients with intermediate AMD, including those on current standard of care therapy (AREDS supplement or equivalent), suggesting that oral saffron may offer additional benefit. Given the considerable burden that AMD imposes on sufferers and the health-care system in general, further consideration and research should be conducted into the role of saffron as therapy for AMD.

Subjects/Keywords: Age-related macular degeneration (AMD); Aflibercept; Saffron

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APA (6^th Edition):

Broadhead, G. K. (2015). Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/14720

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Broadhead, Geoffrey Kenneth. “Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration .” 2015. Thesis, University of Sydney. Accessed February 28, 2021. http://hdl.handle.net/2123/14720.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Broadhead, Geoffrey Kenneth. “Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration .” 2015. Web. 28 Feb 2021.

Vancouver:

Broadhead GK. Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration . [Internet] [Thesis]. University of Sydney; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2123/14720.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Broadhead GK. Emerging Therapeutic Options in the Management of Age-Related Macular Degeneration . [Thesis]. University of Sydney; 2015. Available from: http://hdl.handle.net/2123/14720

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of New South Wales

8. Ly, Angelica. Multimodal imaging in age-related macular degeneration.

Degree: Optometry & Vision Science, 2018, University of New South Wales

URL: http://handle.unsw.edu.au/1959.4/60154 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51223/SOURCE02?view=true

► Age-related macular degeneration (AMD) is a leading cause of blindness and affects approximately one in sevenAustralians aged 50 years and above. Currently, this complex condition… (more)

▼ Age-related macular degeneration (AMD) is a leading cause of blindness and affects approximately one in sevenAustralians aged 50 years and above. Currently, this complex condition is not easily and uniformly assessed. Thesigns of AMD differ between eyes and also occur in other macular disorders. This hinders accurate diagnosis andclassification, which is fundamental to optimal patient care. Ocular imaging and visual function assessment have thepotential to minimise the devastating consequences of disease through early detection. However, multiple devicesare now commercially available and the impact of these technologies in clinical practice may not be straightforward.For instance, their usefulness may depend on accessibility and the operator’s knowledge and clinical skills. Theimpact on patient management, as well as alternative models of eye-care delivery, requires clarification.This thesis aims to explore the current and potential utility of imaging technologies (optical coherence tomography,infrared imaging, monochromatic retinal photography and fundus autofluorescence) in the assessment andmanagement of AMD and other diseases of retinal pigment epithelium dysfunction.The findings show that optometrists self-describe high levels of practice competency and make ready use of imagingin everyday practice. However, they also unwittingly demonstrated low awareness of the evidence base in AMD.Furthermore, when their interpretation of images was tested using a series of case vignettes, their diagnosticaccuracy as a group improved by only five per cent (from 61 per cent to 66 per cent); their tendency to referincreased by four per cent. These factors might be improved through education.A series of open-access, chair-side reference charts were consequently devised to help optometrists use imagingtechnologies more effectively in clinical practice. The additive contribution of multimodal structural and functionaltesting was particularly emphasised. Finally, a novel model of intermediate-tier eye-care in Australia was shown tosubstantially reduce the number of false positive cases or cases without a specific diagnosis. Interestingly, this modelwas acclaimed by reviewers as “scoring highly for originality and of international relevance”. Most excitingly, thethesis concludes with future directions regarding collaborative care and multimodal imaging, where detection ofdisease might be facilitated via a computational approach. Advisors/Committee Members: Kalloniatis, Michael, Optometry & Vision Science, Faculty of Science, UNSW, Nivison-Smith, Lisa, Optometry & Vision Science, Faculty of Science, UNSW.

Subjects/Keywords: Multimodal imaging; Age-related macular degeneration (AMD)

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APA (6^th Edition):

Ly, A. (2018). Multimodal imaging in age-related macular degeneration. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/60154 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51223/SOURCE02?view=true

Chicago Manual of Style (16^th Edition):

Ly, Angelica. “Multimodal imaging in age-related macular degeneration.” 2018. Doctoral Dissertation, University of New South Wales. Accessed February 28, 2021. http://handle.unsw.edu.au/1959.4/60154 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51223/SOURCE02?view=true.

MLA Handbook (7^th Edition):

Ly, Angelica. “Multimodal imaging in age-related macular degeneration.” 2018. Web. 28 Feb 2021.

Vancouver:

Ly A. Multimodal imaging in age-related macular degeneration. [Internet] [Doctoral dissertation]. University of New South Wales; 2018. [cited 2021 Feb 28]. Available from: http://handle.unsw.edu.au/1959.4/60154 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51223/SOURCE02?view=true.

Council of Science Editors:

Ly A. Multimodal imaging in age-related macular degeneration. [Doctoral Dissertation]. University of New South Wales; 2018. Available from: http://handle.unsw.edu.au/1959.4/60154 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:51223/SOURCE02?view=true

University of Texas – Austin

9. Jiang, Shan, 1986-. Safety, effectiveness, and cost among Texas Medicaid patients with Diabetic Macular Edema (DME) or Age-Related Macular Degeneration (AMD).

Degree: PhD, Pharmaceutical Sciences, 2014, University of Texas – Austin

URL: http://hdl.handle.net/2152/28478

► Although bevacizumab is one of the most commonly used treatments for DME and AMD, there are concerns regarding safety and effectiveness due to its off-label… (more)

▼ Although bevacizumab is one of the most commonly used treatments for DME and AMD, there are concerns regarding safety and effectiveness due to its off-label use. The study objectives were to determine if: 1) the risk of cardiovascular/ hemorrhagic events (safety) and visual impairment (effectiveness) differed by bevacizumab use (i.e., use vs. non-use and number of treatments) among DME and AMD patients; and 2) direct medical costs differed between DME and DME control patients. A retrospective cohort analysis was conducted with Texas Medicaid medical and prescription data (9/1/07-12/31/12) for patients: 18- 63 years, continuously enrolled 1-year pre- and post-index, and diagnosed with DME or AMD. The index date was the first date of diagnosis. The dependent variables were: 1) cardiovascular/hemorrhagic risk; 2) visual impairment; 3) direct medical costs. The independent variables were bevacizumab use and number of bevacizumab treatments. Covariates were disease state, Charlson Comorbidity Index (CCI) score, total medication use, number of laser treatments, and demographics. Propensity scoring technique was used to match: 1) bevacizumab users and non-users; and 2) DME and DME control cohorts. Descriptive analyses, logistic regression, Cox-regression, and generalized linear models were employed. A final cohort of 3,647 DME, 297 AMD, and 57,897 DME control patients were included. The majority (DME and AMD) was between 45-63 years of age (86.6%), Hispanic (54.0%), and female (65.1%). The mean total number of unique medications and mean CCI were 2.7 ± 3.4 and 6.0 ± 3.3, respectively. Total direct medical costs/person (Mean (±SD)) incurred by DME, DME control, and AMD subjects in the post-index period were 6,704(±9,338), 5,495(±10,153), and 4,935(±12,702), respectively. No differences in cardiovascular/ hemorrhagic risk were found between bevacizumab users and non-users. The claims data lacks the detail to determine the effectiveness of bevacizumab. DME control patients had lower overall direct medical costs than DME patients (p<0.0001). In conclusion, although bevacizumab is a less expensive off-label alternative of ranibizumab, the choice between bevacizumab and ranibizumab should be made through careful consideration. However, as the use of anti-VEGF agent increases, further research should be conducted to determine if any changes in cardiovascular adverse events occur. Advisors/Committee Members: Barner, Jamie C. (advisor).

Subjects/Keywords: Diabetic macular edema; Age-related macular degeneration; Safety; Cost; Medicaid

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APA (6^th Edition):

Jiang, Shan, 1. (2014). Safety, effectiveness, and cost among Texas Medicaid patients with Diabetic Macular Edema (DME) or Age-Related Macular Degeneration (AMD). (Doctoral Dissertation). University of Texas – Austin. Retrieved from http://hdl.handle.net/2152/28478

Chicago Manual of Style (16^th Edition):

Jiang, Shan, 1986-. “Safety, effectiveness, and cost among Texas Medicaid patients with Diabetic Macular Edema (DME) or Age-Related Macular Degeneration (AMD).” 2014. Doctoral Dissertation, University of Texas – Austin. Accessed February 28, 2021. http://hdl.handle.net/2152/28478.

MLA Handbook (7^th Edition):

Jiang, Shan, 1986-. “Safety, effectiveness, and cost among Texas Medicaid patients with Diabetic Macular Edema (DME) or Age-Related Macular Degeneration (AMD).” 2014. Web. 28 Feb 2021.

Vancouver:

Jiang, Shan 1. Safety, effectiveness, and cost among Texas Medicaid patients with Diabetic Macular Edema (DME) or Age-Related Macular Degeneration (AMD). [Internet] [Doctoral dissertation]. University of Texas – Austin; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2152/28478.

Council of Science Editors:

Jiang, Shan 1. Safety, effectiveness, and cost among Texas Medicaid patients with Diabetic Macular Edema (DME) or Age-Related Macular Degeneration (AMD). [Doctoral Dissertation]. University of Texas – Austin; 2014. Available from: http://hdl.handle.net/2152/28478

10. Mulfaul, Kelly. Investigating a role for TLR signalling and complement deposition in retinal degeneration.

Degree: School of Medicine. Discipline of Clinical Medicine, 2018, Trinity College Dublin

URL: http://hdl.handle.net/2262/83837

► Age-related macular degeneration (AMD) and Retinitis Pigmentosa (RP) are the most common cause of progressive vision loss in the developed world. AMD is a multifactorial… (more)

▼ Age-related macular degeneration (AMD) and Retinitis Pigmentosa (RP) are the most common cause of progressive vision loss in the developed world. AMD is a multifactorial disease with both genetic and environmental risk factors and has a worldwide prevalence of 196 million. RP is a group of inherited retinal degenerations caused by up to 60 mutations which effect the function of photoreceptors. RP affects 1:4000 people worldwide. Aberrant immune activation, complement deposition and oxidative stress have all been linked to AMD pathogenesis, however, the mechanisms initiating AMD progression are still unknown. Pathological hallmarks of AMD include marked deposition of complement factor 3 (C3) sub-retinal pigment epithelium (RPE) and increased deposition of the oxidative protein modification 2-(-carboxyethyl) pyrrole (CEP). It is now widely accepted that inappropriate activation of the alternative complement cascade is involved in AMD progression, however, the cause of C3 deposition and the outcome remains elusive. Recently, CEP has been identified as an endogenous ligand for TLR2. TLR2 activation has been previously linked to complement deposition in a mouse model of ischemia/reperfusion injury, where blocking TLR2 significantly reduced C3 deposition. Given the evidence of crosstalk between TLRs and complement we hypothesised that TLR2 ligation is responsible for C3 deposition in AMD. We observed positive staining of TLR2 and its adaptors Mal and MyD88 in normal and AMD donor eyes and have demonstrated TLR2 ligation induces alternative complement factor expression in monocytes, macrophages and the RPE. Interestingly, C3d is released basolateraly from polarised RPE cells corresponding with C3d staining observed sub-RPE in AMD donor eyes. Stimulation with CEP-HSA induced robust secretion of C3 and CFB from the RPE. CFB is an initiating member of the alternative complement pathway and C3 is a central molecule which once activated can further amplify complement activation. In the presence of normal human serum CEP-HSA promoted the alternative complement pathway to completion resulting in terminal sub-lytic Membrane attack complex (MAC) formation and monocyte chemoattractant protein-1 (MCP-1) secretion. Furthermore, we demonstrated that the anaphylatoxins C3a and C5a produced during proteolytic activation of complement can synergize with TLR2 ligands to induce robust pro-inflammatory cytokine secretion from mononuclear cells. We found that TLR2 induced complement activation was dependent on the presence of its adaptor proteins Mal and MyD88. Furthermore, MAC formation was inhibited using anti-TLR2 blocking antibody and a Mal peptide inhibitor. Demonstrating for the first time that CEP can induce proteolytic complement activation and MAC formation via TLR2 activation. To assess whether blocking TLR2 would be effective in preventing RD we used two mouse models of oxidative retinal degeneration. Both models mimic some aspects of AMD including RPE atrophy, photoreceptor loss and C3 deposition. We have demonstrated that… Advisors/Committee Members: Doyle, Sarah.

Subjects/Keywords: Age Related Macular Degeneration; Retinal Degeneration; Toll like receptors; Complement; Immunology

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mulfaul, K. (2018). Investigating a role for TLR signalling and complement deposition in retinal degeneration. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/83837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mulfaul, Kelly. “Investigating a role for TLR signalling and complement deposition in retinal degeneration.” 2018. Thesis, Trinity College Dublin. Accessed February 28, 2021. http://hdl.handle.net/2262/83837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mulfaul, Kelly. “Investigating a role for TLR signalling and complement deposition in retinal degeneration.” 2018. Web. 28 Feb 2021.

Vancouver:

Mulfaul K. Investigating a role for TLR signalling and complement deposition in retinal degeneration. [Internet] [Thesis]. Trinity College Dublin; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2262/83837.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mulfaul K. Investigating a role for TLR signalling and complement deposition in retinal degeneration. [Thesis]. Trinity College Dublin; 2018. Available from: http://hdl.handle.net/2262/83837

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Boston University

11. Hoang, Hai. The role of retinoic acid related orphan receptor alpha in age-related macular degeneration.

Degree: 2015, Boston University

URL: http://hdl.handle.net/2144/16259

► Age-related macular degeneration (AMD) is a prevalent cause of vision loss and irreversible blindness that affects more than 11 million Americans. AMD is a multifactorial… (more)

Subjects/Keywords: Ophthalmology; RAR-related orphan receptor alpha; RORA; Age-related macular degeneration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hoang, H. (2015). The role of retinoic acid related orphan receptor alpha in age-related macular degeneration. (Thesis). Boston University. Retrieved from http://hdl.handle.net/2144/16259

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Hoang, Hai. “The role of retinoic acid related orphan receptor alpha in age-related macular degeneration.” 2015. Thesis, Boston University. Accessed February 28, 2021. http://hdl.handle.net/2144/16259.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Hoang, Hai. “The role of retinoic acid related orphan receptor alpha in age-related macular degeneration.” 2015. Web. 28 Feb 2021.

Vancouver:

Hoang H. The role of retinoic acid related orphan receptor alpha in age-related macular degeneration. [Internet] [Thesis]. Boston University; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/2144/16259.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Hoang H. The role of retinoic acid related orphan receptor alpha in age-related macular degeneration. [Thesis]. Boston University; 2015. Available from: http://hdl.handle.net/2144/16259

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

York University

12. Mohaghegh, Navid. Open Platform to Detect and Monitor Macular Disorders.

Degree: PhD, Computer Science, 2019, York University

URL: https://yorkspace.library.yorku.ca/xmlui/handle/10315/36718

► Macular disorders (MDs) such as Age-related Macular Degeneration (AMD) and Central Serous Retinopathy (CSR) cause Visual Distortions (VDs) while affecting human vision and the quality… (more)

▼ Macular disorders (MDs) such as Age-related Macular Degeneration (AMD) and Central Serous Retinopathy (CSR) cause Visual Distortions (VDs) while affecting human vision and the quality of life. Home-monitoring helps with disorder early detection and possibly slow down or even progress prevention while reducing the risk of vision loss and medical management costs. We addressed the challenge of developing accurate, rapid, and low-cost home monitoring technology for the detection and progress assessment of MDs. The proposed methods allow the detection of small VDs using a novel approach called NGRID. The proposed NGRID platform is a unified software and hardware system that assist eye-care professionals in running the visual tests from hospitals or remotely at patients' home. Advanced programming techniques such as Standard Vector Graphic (SVG) and voice recognition were used to develop the required software. The high security, capacity, and availability of the computer cluster running NGRID enable the access of millions of people to run the test and assess the progress of their MDs at home. NGRID sends the results to the medical practitioner to better manage the patients. We tested CSR patients using NGRID. The patients were asked to answer if they see the VD test frames wavy or with missing parts. Patient's voice is processed to extract the answers and detect metamorphopsia or scotoma, and results displayed in a graph called heatmap, which visually shows how the visual field is affected. Furthermore, we successfully verified the heatmaps with patients' Optical Coherence Tomography (OCT) images, which is the golden standard methodology for MD diagnostic. We confirmed the location of the detected VDs with the patients once they gain normal vision. The proposed NGRID research platform can offer significant advantages for home monitoring and subsequently, control of MDs. NGRID opened new avenues towards the generation of first MD big data suitable for medical industries. Finally, NGRID aims to offer medical practitioners better ways to monitor patients at home, where using OCT is not possible. Clinical trials for NGRID on other MDs such as AMD may allow medical practitioners for faster intervention when Anti-Vascular Endothelial Growth Factor (Anti-VEGF) is needed. Advisors/Committee Members: Ghafar-Zadeh, Ebrahim (advisor), Magierowski, Sebastian (advisor).

Subjects/Keywords: Computer science; Macular Disorders; Age-Related Macular Degeneration; AMD; Central Serous Chorioretinopathy; CSR

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mohaghegh, N. (2019). Open Platform to Detect and Monitor Macular Disorders. (Doctoral Dissertation). York University. Retrieved from https://yorkspace.library.yorku.ca/xmlui/handle/10315/36718

Chicago Manual of Style (16^th Edition):

Mohaghegh, Navid. “Open Platform to Detect and Monitor Macular Disorders.” 2019. Doctoral Dissertation, York University. Accessed February 28, 2021. https://yorkspace.library.yorku.ca/xmlui/handle/10315/36718.

MLA Handbook (7^th Edition):

Mohaghegh, Navid. “Open Platform to Detect and Monitor Macular Disorders.” 2019. Web. 28 Feb 2021.

Vancouver:

Mohaghegh N. Open Platform to Detect and Monitor Macular Disorders. [Internet] [Doctoral dissertation]. York University; 2019. [cited 2021 Feb 28]. Available from: https://yorkspace.library.yorku.ca/xmlui/handle/10315/36718.

Council of Science Editors:

Mohaghegh N. Open Platform to Detect and Monitor Macular Disorders. [Doctoral Dissertation]. York University; 2019. Available from: https://yorkspace.library.yorku.ca/xmlui/handle/10315/36718

Louisiana State University

13. Guerra Gaitan, Genesis Gisselle. Modifiable and Non-Modifiable Factors Related to the Macular Pigment Optical Density (MPOD) in a Population of College-Aged Adults.

Degree: MS, Eye Diseases, 2017, Louisiana State University

URL: https://digitalcommons.lsu.edu/gradschool_theses/4322

► Age-related macular degeneration (AMD) is one of the leading causes of blindness among the elderly worldwide. Retinal problems, specifically in the macula, hold potential… (more)

▼ Age-related macular degeneration (AMD) is one of the leading causes of blindness among the elderly worldwide. Retinal problems, specifically in the macula, hold potential for development of AMD. Macular pigment optical density (MPOD) gives a measure of the thickness of the macula and therefore health of the macula. Some of the populations at risk for development of AMD include being white, female, and having light eye color. Factors related to the development of the disease have been divided into modifiable and non-modifiable; non-modifiable include a genetic predisposition. Control of modifiable factors, including body mass index (BMI) and diet [dietary intake of lutein+ zeaxanthin (L+Z) and docosahexaenoic acid + eicosapentaenoic acid (DHA, 22:6n3 +EPA, 20:5n3)], have been associated with a reduction in prevalence of the disease. To date, few studies have evaluated MPOD in young adults, and to the best of our knowledge no studies have evaluated the relationship of MPOD to those factors in that population. We posed the question: What factors (diet, BMI, gender, ethnicity, eye color) affect macular health in a young adult population? MPOD was measured for 475 young adults (18-28 years old) using a macularmetrics densitometer. Dietary information was collected using a food frequency questionnaire and a 24-hour dietary recall. BMI for each subject was calculated. Young females had lower MPOD values than males (0.3295 vs 0.3659). There was no difference with BMI or eye color. There were no differences among normal, overweight and obese BMI groups (p > 0.05). However, combined normal+ overweight subjects vs obese had higher MPOD (p= 0.032). Employing sequential regression, the addition of DHA+EPA and L+Z improved the model beyond that provided by gender and BMI. Dietary intake of DHA+EPA and L+Z was higher in males than in females. However, in general, the consumption of those nutrients was low in both males and females. In conclusion, female gender and obese BMI seem to be related to MPOD in this young population. Dietary information points to a necessity for early education about eye health, nutrition and body weight for young adults.

Subjects/Keywords: Macular pigment optical density; nutrition; lutein; zeaxanthin; docosahexaenoic aci; age related macular degeneration; young adults

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Guerra Gaitan, G. G. (2017). Modifiable and Non-Modifiable Factors Related to the Macular Pigment Optical Density (MPOD) in a Population of College-Aged Adults. (Masters Thesis). Louisiana State University. Retrieved from https://digitalcommons.lsu.edu/gradschool_theses/4322

Chicago Manual of Style (16^th Edition):

Guerra Gaitan, Genesis Gisselle. “Modifiable and Non-Modifiable Factors Related to the Macular Pigment Optical Density (MPOD) in a Population of College-Aged Adults.” 2017. Masters Thesis, Louisiana State University. Accessed February 28, 2021. https://digitalcommons.lsu.edu/gradschool_theses/4322.

MLA Handbook (7^th Edition):

Guerra Gaitan, Genesis Gisselle. “Modifiable and Non-Modifiable Factors Related to the Macular Pigment Optical Density (MPOD) in a Population of College-Aged Adults.” 2017. Web. 28 Feb 2021.

Vancouver:

Guerra Gaitan GG. Modifiable and Non-Modifiable Factors Related to the Macular Pigment Optical Density (MPOD) in a Population of College-Aged Adults. [Internet] [Masters thesis]. Louisiana State University; 2017. [cited 2021 Feb 28]. Available from: https://digitalcommons.lsu.edu/gradschool_theses/4322.

Council of Science Editors:

Guerra Gaitan GG. Modifiable and Non-Modifiable Factors Related to the Macular Pigment Optical Density (MPOD) in a Population of College-Aged Adults. [Masters Thesis]. Louisiana State University; 2017. Available from: https://digitalcommons.lsu.edu/gradschool_theses/4322

York University

14. Mohaghegh, Navid. Open Platform to Detect and Monitor Macular Disorders.

Degree: PhD, Computer Science, 2019, York University

URL: http://hdl.handle.net/10315/36718

► Macular disorders (MDs) such as Age-related Macular Degeneration (AMD) and Central Serous Retinopathy (CSR) cause Visual Distortions (VDs) while affecting human vision and the quality… (more)

▼ Macular disorders (MDs) such as Age-related Macular Degeneration (AMD) and Central Serous Retinopathy (CSR) cause Visual Distortions (VDs) while affecting human vision and the quality of life. Home-monitoring helps with disorder early detection and possibly slow down or even progress prevention while reducing the risk of vision loss and medical management costs. We addressed the challenge of developing accurate, rapid, and low-cost home monitoring technology for the detection and progress assessment of MDs. The proposed methods allow the detection of small VDs using a novel approach called NGRID. The proposed NGRID platform is a unified software and hardware system that assist eye-care professionals in running the visual tests from hospitals or remotely at patients' home. Advanced programming techniques such as Standard Vector Graphic (SVG) and voice recognition were used to develop the required software. The high security, capacity, and availability of the computer cluster running NGRID enable the access of millions of people to run the test and assess the progress of their MDs at home. NGRID sends the results to the medical practitioner to better manage the patients. We tested CSR patients using NGRID. The patients were asked to answer if they see the VD test frames wavy or with missing parts. Patient's voice is processed to extract the answers and detect metamorphopsia or scotoma, and results displayed in a graph called heatmap, which visually shows how the visual field is affected. Furthermore, we successfully verified the heatmaps with patients' Optical Coherence Tomography (OCT) images, which is the golden standard methodology for MD diagnostic. We confirmed the location of the detected VDs with the patients once they gain normal vision. The proposed NGRID research platform can offer significant advantages for home monitoring and subsequently, control of MDs. NGRID opened new avenues towards the generation of first MD big data suitable for medical industries. Finally, NGRID aims to offer medical practitioners better ways to monitor patients at home, where using OCT is not possible. Clinical trials for NGRID on other MDs such as AMD may allow medical practitioners for faster intervention when Anti-Vascular Endothelial Growth Factor (Anti-VEGF) is needed. Advisors/Committee Members: Ghafar-Zadeh, Ebrahim (advisor), Magierowski, Sebastian (advisor).

Subjects/Keywords: Computer science; Macular Disorders; Age-Related Macular Degeneration; AMD; Central Serous Chorioretinopathy; CSR

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mohaghegh, N. (2019). Open Platform to Detect and Monitor Macular Disorders. (Doctoral Dissertation). York University. Retrieved from http://hdl.handle.net/10315/36718

Chicago Manual of Style (16^th Edition):

Mohaghegh, Navid. “Open Platform to Detect and Monitor Macular Disorders.” 2019. Doctoral Dissertation, York University. Accessed February 28, 2021. http://hdl.handle.net/10315/36718.

MLA Handbook (7^th Edition):

Mohaghegh, Navid. “Open Platform to Detect and Monitor Macular Disorders.” 2019. Web. 28 Feb 2021.

Vancouver:

Mohaghegh N. Open Platform to Detect and Monitor Macular Disorders. [Internet] [Doctoral dissertation]. York University; 2019. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10315/36718.

Council of Science Editors:

Mohaghegh N. Open Platform to Detect and Monitor Macular Disorders. [Doctoral Dissertation]. York University; 2019. Available from: http://hdl.handle.net/10315/36718

15. Supanji. HtrA1expression under oxidative stress : 酸化ストレス下におけるHtrA1の発現と加齢黄斑変性について; サンカストレスカニオケル HtrA1 ノハツゲントカレイオウハンヘンセイニツイテ.

Degree: 博士(バイオサイエンス), Nara Institute of Science and Technology / 奈良先端科学技術大学院大学

URL: http://hdl.handle.net/10061/8828

Subjects/Keywords: Age-related macular degeneration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Supanji. (n.d.). HtrA1expression under oxidative stress : 酸化ストレス下におけるHtrA1の発現と加齢黄斑変性について; サンカストレスカニオケル HtrA1 ノハツゲントカレイオウハンヘンセイニツイテ. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/8828

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Supanji. “HtrA1expression under oxidative stress : 酸化ストレス下におけるHtrA1の発現と加齢黄斑変性について; サンカストレスカニオケル HtrA1 ノハツゲントカレイオウハンヘンセイニツイテ.” Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed February 28, 2021. http://hdl.handle.net/10061/8828.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Supanji. “HtrA1expression under oxidative stress : 酸化ストレス下におけるHtrA1の発現と加齢黄斑変性について; サンカストレスカニオケル HtrA1 ノハツゲントカレイオウハンヘンセイニツイテ.” Web. 28 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
No year of publication.

Vancouver:

Supanji. HtrA1expression under oxidative stress : 酸化ストレス下におけるHtrA1の発現と加齢黄斑変性について; サンカストレスカニオケル HtrA1 ノハツゲントカレイオウハンヘンセイニツイテ. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10061/8828.

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Supanji. HtrA1expression under oxidative stress : 酸化ストレス下におけるHtrA1の発現と加齢黄斑変性について; サンカストレスカニオケル HtrA1 ノハツゲントカレイオウハンヘンセイニツイテ. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; Available from: http://hdl.handle.net/10061/8828

Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

16. Shibagaki, Keiichi. Investigation of Pramipexole as Potential Therapeutic Agent for Age-related Macular Degeneration : Pramipexoleの加齢黄斑変性治療薬としての応用可能性検討; Pramipexole ノカレイオウハンヘンセイチリョウヤクトシテノオウヨウカノウセイケントウ.

Degree: 博士(バイオサイエンス), Nara Institute of Science and Technology / 奈良先端科学技術大学院大学

URL: http://hdl.handle.net/10061/10434

Subjects/Keywords: Age-related macular degeneration

Record Details Similar Records Cite « Share

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Shibagaki, K. (n.d.). Investigation of Pramipexole as Potential Therapeutic Agent for Age-related Macular Degeneration : Pramipexoleの加齢黄斑変性治療薬としての応用可能性検討; Pramipexole ノカレイオウハンヘンセイチリョウヤクトシテノオウヨウカノウセイケントウ. (Thesis). Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Retrieved from http://hdl.handle.net/10061/10434

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Shibagaki, Keiichi. “Investigation of Pramipexole as Potential Therapeutic Agent for Age-related Macular Degeneration : Pramipexoleの加齢黄斑変性治療薬としての応用可能性検討; Pramipexole ノカレイオウハンヘンセイチリョウヤクトシテノオウヨウカノウセイケントウ.” Thesis, Nara Institute of Science and Technology / 奈良先端科学技術大学院大学. Accessed February 28, 2021. http://hdl.handle.net/10061/10434.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Shibagaki, Keiichi. “Investigation of Pramipexole as Potential Therapeutic Agent for Age-related Macular Degeneration : Pramipexoleの加齢黄斑変性治療薬としての応用可能性検討; Pramipexole ノカレイオウハンヘンセイチリョウヤクトシテノオウヨウカノウセイケントウ.” Web. 28 Feb 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Shibagaki K. Investigation of Pramipexole as Potential Therapeutic Agent for Age-related Macular Degeneration : Pramipexoleの加齢黄斑変性治療薬としての応用可能性検討; Pramipexole ノカレイオウハンヘンセイチリョウヤクトシテノオウヨウカノウセイケントウ. [Internet] [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10061/10434.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Shibagaki K. Investigation of Pramipexole as Potential Therapeutic Agent for Age-related Macular Degeneration : Pramipexoleの加齢黄斑変性治療薬としての応用可能性検討; Pramipexole ノカレイオウハンヘンセイチリョウヤクトシテノオウヨウカノウセイケントウ. [Thesis]. Nara Institute of Science and Technology / 奈良先端科学技術大学院大学; Available from: http://hdl.handle.net/10061/10434

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Vanderbilt University

17. Lapierre-Landry, Maryse. Development of Photothermal Optical Coherence Tomography for Retinal Imaging.

Degree: PhD, Biomedical Engineering, 2018, Vanderbilt University

URL: http://hdl.handle.net/1803/13871

► There is a need for molecular imaging techniques in the eye to better understand disease progression, identify early disease markers, and evaluate new treatment options.… (more)

Subjects/Keywords: indocyanine green; gold nanoparticles; melanin; molecular imaging; age-related macular degeneration

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lapierre-Landry, M. (2018). Development of Photothermal Optical Coherence Tomography for Retinal Imaging. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/13871

Chicago Manual of Style (16^th Edition):

Lapierre-Landry, Maryse. “Development of Photothermal Optical Coherence Tomography for Retinal Imaging.” 2018. Doctoral Dissertation, Vanderbilt University. Accessed February 28, 2021. http://hdl.handle.net/1803/13871.

MLA Handbook (7^th Edition):

Lapierre-Landry, Maryse. “Development of Photothermal Optical Coherence Tomography for Retinal Imaging.” 2018. Web. 28 Feb 2021.

Vancouver:

Lapierre-Landry M. Development of Photothermal Optical Coherence Tomography for Retinal Imaging. [Internet] [Doctoral dissertation]. Vanderbilt University; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1803/13871.

Council of Science Editors:

Lapierre-Landry M. Development of Photothermal Optical Coherence Tomography for Retinal Imaging. [Doctoral Dissertation]. Vanderbilt University; 2018. Available from: http://hdl.handle.net/1803/13871

Vanderbilt University

18. Hoffman, Joshua David. Modeling Macular Degeneration Using Quantitative Phenotypes.

Degree: PhD, Human Genetics, 2015, Vanderbilt University

URL: http://hdl.handle.net/1803/10680

► Age-related macular degeneration (AMD) is one of the most common causes of visual impairment in the United States (US). Although a multitude of studies have… (more)

Subjects/Keywords: AMD; genetics; Age-Related Macular Degeneration; genomics; assocation analysis; linkage analysis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hoffman, J. D. (2015). Modeling Macular Degeneration Using Quantitative Phenotypes. (Doctoral Dissertation). Vanderbilt University. Retrieved from http://hdl.handle.net/1803/10680

Chicago Manual of Style (16^th Edition):

Hoffman, Joshua David. “Modeling Macular Degeneration Using Quantitative Phenotypes.” 2015. Doctoral Dissertation, Vanderbilt University. Accessed February 28, 2021. http://hdl.handle.net/1803/10680.

MLA Handbook (7^th Edition):

Hoffman, Joshua David. “Modeling Macular Degeneration Using Quantitative Phenotypes.” 2015. Web. 28 Feb 2021.

Vancouver:

Hoffman JD. Modeling Macular Degeneration Using Quantitative Phenotypes. [Internet] [Doctoral dissertation]. Vanderbilt University; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/1803/10680.

Council of Science Editors:

Hoffman JD. Modeling Macular Degeneration Using Quantitative Phenotypes. [Doctoral Dissertation]. Vanderbilt University; 2015. Available from: http://hdl.handle.net/1803/10680

University of Illinois – Chicago

19. Parthasarathy, Rajni. Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues.

Degree: 2015, University of Illinois – Chicago

URL: http://hdl.handle.net/10027/19762

► Amyloid-beta (Aβ), a 38-43 amino acid peptide generated in the eye and other tissues, has been hypothesized to exert toxic effects that contribute to the… (more)

▼ Amyloid-beta (Aβ), a 38-43 amino acid peptide generated in the eye and other tissues, has been hypothesized to exert toxic effects that contribute to the progression and pathology of age-related macular degeneration and other retinal degenerative diseases. My thesis study addresses the engineering of a treatment approach that enables the control of Aβ levels in the living eye. Neprilysin (NEP), a native endopeptidase that cleaves Aβ into inactive products, is a membrane-anchored protein. However, the recombinant-catalytic domain of NEP (termed sNEP) is soluble and retains catalytic activity. We have investigated the ability of intravitreally injected sNEP to reduce, in vivo, ocular levels of Aβ40 and Aβ42, (40 and 42 amino acids respectively) two principal Aβ forms. Anesthetized 10-month wildtype (C57BL/6J) mice, and 2-3-month 5XFAD transgenic mice overexpressing human Aβ42, received intravitreal injections of phosphate-buffered saline (PBS) containing sNEP. Treated mice were maintained for varying periods. Harvested eye tissues (combined lens, vitreous, retina, retinal pigment epithelium and choroid) were homogenized, extracted with PBS and analyzed for Aβ (ELISA) and protein (Bradford assay) to enable determinations of Aβ concentrations (pmol per g protein). Analytical procedures developed in the study included those for terminating sNEP activity prior to animal euthanasia, using the sNEP inhibitor phosphoramidon. sNEP activity remaining at defined post-sNEP-treatment times was analyzed by fluorometric assay. Retinal function in sNEP-treated eyes was analyzed by electroretinography (ERG). Key results obtained in the study include the following. (1) Untreated C57BL/6J eyes and 5XFAD eyes exhibit substantial Aβ levels. (2) Intravitreally delivered sNEP exhibits a concentration-dependent and time-dependent activity in reducing ocular Aβ levels. (3) Although sNEP is cleared rapidly from the eye after delivery, Aβ levels remain low for up to several weeks. (4) As determined at a fixed time following sNEP treatment that substantially reduces Aβ, C57BL/6J and 5XFAD mouse eyes exhibit robust ERG responsiveness, indicating good tolerance of the eye tissues to the sNEP treatment. Overall, the results of this study establish that sNEP delivery to the mouse eye enables substantial in vivo reductions in Aβ levels. The data encourage further study of intravitreal sNEP treatment for investigational and, potentially, therapeutic applications. Advisors/Committee Members: Pepperberg, David R. (advisor), Kay, Brian K. (committee member), Hetling, John R. (committee member), Eddington, David T. (committee member), Shahidi, Mahnaz (committee member).

Subjects/Keywords: Amyloid-beta; Neprilysin; Eye tissues; Age-related macular degeneration; mouse

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APA (6^th Edition):

Parthasarathy, R. (2015). Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues. (Thesis). University of Illinois – Chicago. Retrieved from http://hdl.handle.net/10027/19762

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Parthasarathy, Rajni. “Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues.” 2015. Thesis, University of Illinois – Chicago. Accessed February 28, 2021. http://hdl.handle.net/10027/19762.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Parthasarathy, Rajni. “Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues.” 2015. Web. 28 Feb 2021.

Vancouver:

Parthasarathy R. Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues. [Internet] [Thesis]. University of Illinois – Chicago; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10027/19762.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Parthasarathy R. Neprilysin-dependent Reduction of Amyloid-beta in Eye Tissues. [Thesis]. University of Illinois – Chicago; 2015. Available from: http://hdl.handle.net/10027/19762

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

20. Dasari, Bhanu Chandar. Cholesterol Dyshomeostasis And Age Related Macular Degeneration.

Degree: PhD, Biomedical Sciences, 2012, University of North Dakota

URL: https://commons.und.edu/theses/1235

► This dissertation work focused on retinal modifications that are relevant to Age-related macular degeneration (AMD) in cholesterol-fed rabbit model of Alzheimer's disease (AD), as… (more)

▼ This dissertation work focused on retinal modifications that are relevant to Age-related macular degeneration (AMD) in cholesterol-fed rabbit model of Alzheimer's disease (AD), as AD and AMD share common features. It is unknown whether cholesterol-fed rabbit model of AD displays any AMD features in retina. Previous research showed 27-hydroxycholesterol (27-OHC) involvement in AD like pathology in organotypic hippocampal slices of rabbit brain and human SHSY-5Y neuroblastoma cells. The extent to which and the mechanisms by which 27-OHC may also cause pathological hallmarks related to AMD are not known. Various studies suggested estrogen's (E2) role in AMD development. 27-OHC is a ligand for estrogen receptor (ER) and liver X receptor (LXR). 25-hydroxycholesterol (25-OHC) and 7-ketocholesterol (7-KC) are also implicated in AMD development. 25-OHC and 7-KC were shown to be ligands of ER and LXR in various cell types. It is unknown whether 27-OHC, 25-OHC and 7-KC influence ER and LXR transcriptional activity in ARPE-19 cells, a spontaneously arising human RPE cell line with normal karyology. ARPE-19 cells and cholesterol-fed rabbit eyes were used for the study. Paraffin embedded eye cross sections were used for immunohistochemistry. Cholesterol was quantified by cholesterol/cholesteryl ester quantification kit. Oxysterols in the rabbit retinas were measured by mass spectrometry. Western blotting for detecting proteins, CytoTox-ONE homogenous membrane integrity assay for measuring lactate dehydrogenase from cells, ELISA (Enzyme-linked immunosorbent assay) for quantifying amyloid beta 1-42 and 1-40, tumor necrosis factor alpha, DCFH-DA (2',7'-dichlorfluorescein-diacetate) assay for measuring reactive oxygen species (ROS), amplex red hydrogen peroxide / peroxidase assay for quantifying hydrogen peroxide and peroxidase activity, JC-1 (5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide) assay for mitochondrial membrane potential detection, TUNEL (Terminal deoxynucleotidyl transferase dUTP nick end labeling) assay for apoptotic cell detection, GSH-Glo assay for glutathione (GSH) quantification, calcium imaging, immunocytochemistry, immunohistochemistry and H&E (hematoxylin and eosin) staining, transfection and dual-luciferase reporter assays were used for this work. This study showed retinal modifications that are relevant to AMD in cholesterol-fed rabbits. Increased abeta levels, decreased apoptosis regulator Bcl-2 levels, increased apoptosis regulator BAX and growth arrest and DNA damage-inducible protein GADD153 proteins, apoptotic cells, and increased generation of ROS were found in retinas from cholesterol-fed rabbit retinas. Furthermore, astrogliosis, drusen-like debris and cholesterol accumulations in retinas from cholesterol-fed rabbits were observed. Oxysterol levels in retinas from cholesterol-fed rabbits were increased. 27-OHC increased abeta peptide production, increased caspase 12 and GADD153, reduced mitochondrial membrane potential, triggered Ca2+ dyshomeostasis,… Advisors/Committee Members: Othman Ghribi.

Subjects/Keywords: Age related macular degeneration; Alzheimer's disease; Cholesterol; nuclear receptor; Oxysterols; Retina

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dasari, B. C. (2012). Cholesterol Dyshomeostasis And Age Related Macular Degeneration. (Doctoral Dissertation). University of North Dakota. Retrieved from https://commons.und.edu/theses/1235

Chicago Manual of Style (16^th Edition):

Dasari, Bhanu Chandar. “Cholesterol Dyshomeostasis And Age Related Macular Degeneration.” 2012. Doctoral Dissertation, University of North Dakota. Accessed February 28, 2021. https://commons.und.edu/theses/1235.

MLA Handbook (7^th Edition):

Dasari, Bhanu Chandar. “Cholesterol Dyshomeostasis And Age Related Macular Degeneration.” 2012. Web. 28 Feb 2021.

Vancouver:

Dasari BC. Cholesterol Dyshomeostasis And Age Related Macular Degeneration. [Internet] [Doctoral dissertation]. University of North Dakota; 2012. [cited 2021 Feb 28]. Available from: https://commons.und.edu/theses/1235.

Council of Science Editors:

Dasari BC. Cholesterol Dyshomeostasis And Age Related Macular Degeneration. [Doctoral Dissertation]. University of North Dakota; 2012. Available from: https://commons.und.edu/theses/1235

University of Melbourne

21. Finger, Robert Patrick. Modeling cost effectiveness of current routine treatments for neovascular age-related macular degeneration from a healthcare payer’s perspective.

Degree: 2013, University of Melbourne

URL: http://hdl.handle.net/11343/38495

► Neovascular age-related macular degeneration (nvAMD) is one of the leading causes of blindness in developed countries including Australia, and current gold-standard treatment is with anti-Vascular… (more)

▼ Neovascular age-related macular degeneration (nvAMD) is one of the leading causes of blindness in developed countries including Australia, and current gold-standard treatment is with anti-Vascular Endothelial Growth Factor (VEGF) drugs. However, cost-effectiveness (CE) of this treatment has to date only been investigated based on phase III clinical trial data, assessing treatment outcomes in only the study eye over only two years. As effectiveness as well as healthcare use are commonly overestimated in clinical trials, and patients require ongoing treatment beyond the first two years, this approach does not reflect day to day clinical reality. Thus, first the long term effectiveness and healthcare resource use in 200 patients treated with anti-VEGF drugs were assessed with up to 5 years follow-up. Mean treatment duration was 37 (±13) months and mean number of injections were 21(±11;7 in year 1-3, 6 in year 4, 5 in year 5). Visual acuity in the treated eye improved from baseline to last follow-up (49 to 56 letters read (ltrs), p<0.001). Fourty % of patients were treated in both eyes during year 1, and almost 50% by year 4. Treatment costs were highest in the first year (A18,296 ± 7,991), and lower for uniocular (A16,123±6,757) than for binocular treatment (21,487±8,610). Cost decreased to A11,420 (62%) in year five, with a much steeper decrease in uniocular treatment (to 7,698; 48%). Secondly the importance of using visual acuity (VA) in both eyes in outcomes and utility assessments in eye health were established in a large sample of over 1300 patients and controls. Using the Vision and Quality of Life (VisQOL) multi-attribute utility instrument (MAUI), utility scores decreased significantly with deteriorating vision in both the better and worse eyes when analysed separately. When stratified by 6 health states of vision impairment in both eyes, called vision states, VisQoL utilities decreased as VA declined in the worse eye despite stable VA in the better eye, demonstrating that calculating utilities based only on better eye VA is likely to underestimate the impact of vision impairment and thus treatment alleviating the impairment, particularly when the better eye has no or little VA loss and the worse eye is moderately to severely visually impaired. Thirdly, the CE of anti-VEGF treatment for nv AMD in standard medical practice in Victoria was assessed based on the collected data. In order to demonstrate the necessity of using vision states which capture VA of both eyes rather than modeling by treated or better eye only, several Markov models (MM) were built using TreeAge software, with health transition probabilities based on our real life treatment and utility inputs as described above. Costs and rewards were discounted at 3.5%/year and final results tested in probabilistic sensitivity analyses. Based on the clinical data MMs ran for 5 years, with all treatment assumed to be…

Subjects/Keywords: age-related macular degeneration; anti-VEGF; cost-effectiveness

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Finger, R. P. (2013). Modeling cost effectiveness of current routine treatments for neovascular age-related macular degeneration from a healthcare payer’s perspective. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/38495

Chicago Manual of Style (16^th Edition):

Finger, Robert Patrick. “Modeling cost effectiveness of current routine treatments for neovascular age-related macular degeneration from a healthcare payer’s perspective.” 2013. Doctoral Dissertation, University of Melbourne. Accessed February 28, 2021. http://hdl.handle.net/11343/38495.

MLA Handbook (7^th Edition):

Finger, Robert Patrick. “Modeling cost effectiveness of current routine treatments for neovascular age-related macular degeneration from a healthcare payer’s perspective.” 2013. Web. 28 Feb 2021.

Vancouver:

Finger RP. Modeling cost effectiveness of current routine treatments for neovascular age-related macular degeneration from a healthcare payer’s perspective. [Internet] [Doctoral dissertation]. University of Melbourne; 2013. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11343/38495.

Council of Science Editors:

Finger RP. Modeling cost effectiveness of current routine treatments for neovascular age-related macular degeneration from a healthcare payer’s perspective. [Doctoral Dissertation]. University of Melbourne; 2013. Available from: http://hdl.handle.net/11343/38495

University of Southern California

22. Choudhury, Farzana. Age related macular degeneration in Latinos: risk factors and impact on quality of life.

Degree: PhD, Epidemiology, 2012, University of Southern California

URL: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/105256/rec/580

► Age related macular degeneration (AMD) is a progressive, potentially irreversible disorder of the macular region of retina that can cause severe loss of central vision… (more)

▼ Age related macular degeneration (AMD) is a progressive, potentially irreversible disorder of the macular region of retina that can cause severe loss of central vision in the late stages. Despite the recent advances in the treatment of AMD, it remains the leading cause of blindness in people over the age of 60 in the Western world with significant impact on their health related quality of life (HRQoL). The global prevalence of AMD remains largely unknown and the full impact of this debilitating disease has not been fully characterized. ❧ The relationship between factors influencing incidence and progression of AMD in Latinos and the impact of AMD on HRQoL in Latinos remain largely unexplored. Therefore, to address these issues, I have used the baseline and 4 years cumulative incidence data from the Los Angeles Latino Eye Study (LALES), a population based cohort study of eye disease in Latinos to investigate predictors of AMD incidence and progression and the impact of AMD on HRQoL. In the first chapter I gave an overview of AMD and my primary aims. I discussed briefly about the retina, macula, the definition, brief pathogenesis, grading scheme and classification of AMD. Then, I discussed briefly about what is known about the risk factors of AMD and its impact on HRQoL. Finally I describe the study population and enumerate the primary aims. ❧ In my first paper (chapter 2) I evaluated the risk factors associated with 4 year incidence and progression of AMD. The risk factors were selected based on literature review and expert clinical opinion. Stepwise logistic regression was used to develop parsimonious multivariable predictive models for each AMD end- points. The results from these analyses revealed that older age and higher pulse pressure were independently associated with the incidence of any AMD and different early AMD lesions in this group of Latinos. Additionally, presence of diabetes mellitus was independently associated with increased retinal pigment and male gender was associated with retinal pigment epithelial depigmentation. Older age and current smoking were independently associated with progression of AMD. Some of the findings were similar to those reported by studies in non-Hispanic whites. The interesting and unique finding in this paper was the association of pulse pressure with incidence of some early maculopathies that were not previously reported in Caucasians. Given the equivocal results for risk factors of AMD in other population based studies and the paucity of data in Latinos, these finding will aide in our understanding of AMD in this unique ethnic group. ❧ The short term and long term impact of AMD on quality of life in Latinos has not been investigated to a great extent. Given the unique socio-demographic, ethnic and cultural characteristics of Latinos it is important to estimate the impact of the patient reported outcomes in this unique group of people. Therefore, for my second paper I investigated the association of prevalent AMD and HRQoL, described in the third chapter. Two validated… Advisors/Committee Members: Azen, Stanley P.McKean-Cowdin, Roberta (Committee Chair), Varma, Rohiti (Committee Member), Gauderman, William James (Committee Member), Nichol, Michael B. (Committee Member).

Subjects/Keywords: age related macular degeneration; Latinos; risk factors; quality of life

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Choudhury, F. (2012). Age related macular degeneration in Latinos: risk factors and impact on quality of life. (Doctoral Dissertation). University of Southern California. Retrieved from http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/105256/rec/580

Chicago Manual of Style (16^th Edition):

Choudhury, Farzana. “Age related macular degeneration in Latinos: risk factors and impact on quality of life.” 2012. Doctoral Dissertation, University of Southern California. Accessed February 28, 2021. http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/105256/rec/580.

MLA Handbook (7^th Edition):

Choudhury, Farzana. “Age related macular degeneration in Latinos: risk factors and impact on quality of life.” 2012. Web. 28 Feb 2021.

Vancouver:

Choudhury F. Age related macular degeneration in Latinos: risk factors and impact on quality of life. [Internet] [Doctoral dissertation]. University of Southern California; 2012. [cited 2021 Feb 28]. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/105256/rec/580.

Council of Science Editors:

Choudhury F. Age related macular degeneration in Latinos: risk factors and impact on quality of life. [Doctoral Dissertation]. University of Southern California; 2012. Available from: http://digitallibrary.usc.edu/cdm/compoundobject/collection/p15799coll3/id/105256/rec/580

University of Melbourne

23. McGuinness, Myra. Quantifying the risk factors for age-related macular degeneration in the presence of survival bias.

Degree: 2018, University of Melbourne

URL: http://hdl.handle.net/11343/218162

► Background:Age-related macular degeneration (AMD) is the most common cause of severe irreversible visual impairment among adults living in developed nations. The number of people living… (more)

▼ Background:Age-related macular degeneration (AMD) is the most common cause of severe irreversible visual impairment among adults living in developed nations. The number of people living with AMD is projected to increase considerably over the coming decades, thus there is a real need to identify modifiable risk factors to delay its onset and progression. Longitudinal studies have been conducted to track exposures and AMD status over many years. However, those at risk of AMD also face the competing risk of death and participant selection for analyses becomes conditional on survival. Under these conditions, traditional statistical methods may produce biased results. Aims: The principal aims of this thesis are: to investigate the plausibility of shared survival-AMD risk-factors by examining the association between AMD and mortality, to examine the performance of a marginal structural model (MSM) and a sensitivity analysis approach when estimating the causal effect of an exposure on an outcome in the presence of survival bias and loss to follow-up, and to extend the sensitivity approach for analysis of a time-varying exposure. In addition, this thesis aims to explore the effect of survival bias when investigating selected risk factors for AMD, namely dietary iron intake, smoking and Mediterranean diet. Methods: Illustrative examples have been drawn from the Melbourne Collaborative Cohort Study (MCCS), a large community-based study conducted between 1990 and 2007. During that time three study waves were completed with assessment of AMD status at the final wave. Analysis of the data from the MCCS and a meta-analysis are presented to assess the association between AMD and mortality. The performances of a MSM (with inverse probability weights for exposure, survival and having non-missing data) and a sensitivity analysis approach for survival bias were assessed via the generation and analysis of simulated data. The sensitivity analysis approach was then extended to allow for the analysis of a time-varying exposure. The performance of this extended approach was compared to that of a MSM in a second simulation study. These statistical methods were then applied to data from the MCCS to examine the association between the selected risk factors and late AMD. Results: Late AMD was found to be associated with increased all-cause and cardiovascular mortality after adjusting for known confounders. MSMs produced biased estimates in the presence of simulated unmeasured survival-outcome confounders. The sensitivity analyses captured the true magnitude of effect within their bounds; however, these bounds were wider than what would be considered clinically useful. The analysis of the effect of smoking on AMD was found to be highly susceptible to survival bias; unlike the exposures of dietary iron and Mediterranean diet, for which the association with mortality was not as strong. Conclusion: The evidence from this thesis supports the theory of shared survival-AMD risk factors which are likely to be unmeasured in large cohort…

Subjects/Keywords: age-related macular degeneration; biostatistics; epidemiology; causal inference; survival bias

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

McGuinness, M. (2018). Quantifying the risk factors for age-related macular degeneration in the presence of survival bias. (Doctoral Dissertation). University of Melbourne. Retrieved from http://hdl.handle.net/11343/218162

Chicago Manual of Style (16^th Edition):

McGuinness, Myra. “Quantifying the risk factors for age-related macular degeneration in the presence of survival bias.” 2018. Doctoral Dissertation, University of Melbourne. Accessed February 28, 2021. http://hdl.handle.net/11343/218162.

MLA Handbook (7^th Edition):

McGuinness, Myra. “Quantifying the risk factors for age-related macular degeneration in the presence of survival bias.” 2018. Web. 28 Feb 2021.

Vancouver:

McGuinness M. Quantifying the risk factors for age-related macular degeneration in the presence of survival bias. [Internet] [Doctoral dissertation]. University of Melbourne; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/11343/218162.

Council of Science Editors:

McGuinness M. Quantifying the risk factors for age-related macular degeneration in the presence of survival bias. [Doctoral Dissertation]. University of Melbourne; 2018. Available from: http://hdl.handle.net/11343/218162

24. Tran, Thi Hà Châu. La reconnaissance des objets et des scènes naturelles dans la dégénérescence maculaire liée à l’âge : Objects and scene recognition in Age-Related Macular Degenration.

Degree: Docteur es, Neurosciences, 2011, Université Lille II – Droit et Santé

URL: http://www.theses.fr/2011LIL2S010

►

La dégénérescence maculaire liée à l’âge (DMLA) est la première cause de cécité chez les sujets âgés dans les pays industrialisés. Les questionnaires sur la… (more)

▼

La dégénérescence maculaire liée à l’âge (DMLA) est la première cause de cécité chez les sujets âgés dans les pays industrialisés. Les questionnaires sur la qualité de vie suggèrent que les patients rencontrent des difficultés dans la recherche d’objets et dans leurs déplacements. En effet, les objets apparaissent rarement isolés dans leur environnement naturel. Ils apparaissent dans un contexte spatial qui peut les masquer en partie et le contraste d’une scène naturelle peut varier au cours de la journée. Nous étudions la capacité de reconnaissance des objets et des scènes naturelles chez les patients DMLA en utilisant des photographies de scènes naturelles. Nous nous sommes intéressés à la reconnaissance des scènes naturelles, puis à la capacité de discrimination figure/fond, à l’effet du contraste sur la reconnaissance des objets, et à la navigation spatiale dans un environnement virtuel. Nous avons comparé la performance de patients avec une DMLA à celle de sujets avec vision normale appariés en âge aux patients. Nos résultats montrent que les patients DMLA sont capables de catégoriser des scènes naturelle ou urbaine, et de discriminer une scène d’intérieur d’une scène extérieur avec un niveau de précision élevé, ce qui est en faveur des modèles centrés sur la scène. Ils détectent mieux un objet lorsque celui-ci était séparé du fond par un espace blanc et lorsque l’objet est présenté dans son contexte naturel que lorsqu’il est présenté sur un fond non structuré et non significatif ; ce qui indique que le fond est traité normalement en vision périphérique. Ils présentent plus de difficultés que les sujets avec vision normale pour détecter un objet dans une scène achromatique dont le contraste est réduit. Une étude sur la navigation spatiale met en évidence une compression de la représentation de l’espace: les sujets avec une DMLA sous-estiment plus la distance virtuelle que les sujets avec vision normale dans la tâche de navigation spatiale. Ces résultats peuvent avoir des applications pratiques dans la rééducation, dans la mise en page des textes et des magazines et dans l’agencement de l’environnement spatial des personnes âgés souffrant de DMLA afin d’améliorer la recherche d’objets, la mobilité et diminuer le risque de chute.

AMD (Age Related Macular Degeneration) is the leading cause of blindness in western countries. Quality of life Questionnaires indicate that people with AMD exhibit difficulties in finding objects and in mobility. In the natural environment, objects seldom appear in isolation. They appear in their natural setting in which they can be masked by other objects. The contrast of a scene may also change, as light varies as a function of the hour in the day and the light source. The objective of the study was to access objects and scene recognition impairments in people with AMD. We studied the perception of natural scenes, figure/ground discrimination, the effect of contrast on object recognition in achromatic scenes, and then navigation and spatial memory in a virtual environment.…

Advisors/Committee Members: Boucart, Muriel (thesis director).

Subjects/Keywords: Reconnaissance ultra rapide d'objets; Scènes naturelles; AMD; Age Related Macular Degeneration

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APA (6^th Edition):

Tran, T. H. C. (2011). La reconnaissance des objets et des scènes naturelles dans la dégénérescence maculaire liée à l’âge : Objects and scene recognition in Age-Related Macular Degenration. (Doctoral Dissertation). Université Lille II – Droit et Santé. Retrieved from http://www.theses.fr/2011LIL2S010

Chicago Manual of Style (16^th Edition):

Tran, Thi Hà Châu. “La reconnaissance des objets et des scènes naturelles dans la dégénérescence maculaire liée à l’âge : Objects and scene recognition in Age-Related Macular Degenration.” 2011. Doctoral Dissertation, Université Lille II – Droit et Santé. Accessed February 28, 2021. http://www.theses.fr/2011LIL2S010.

MLA Handbook (7^th Edition):

Tran, Thi Hà Châu. “La reconnaissance des objets et des scènes naturelles dans la dégénérescence maculaire liée à l’âge : Objects and scene recognition in Age-Related Macular Degenration.” 2011. Web. 28 Feb 2021.

Vancouver:

Tran THC. La reconnaissance des objets et des scènes naturelles dans la dégénérescence maculaire liée à l’âge : Objects and scene recognition in Age-Related Macular Degenration. [Internet] [Doctoral dissertation]. Université Lille II – Droit et Santé 2011. [cited 2021 Feb 28]. Available from: http://www.theses.fr/2011LIL2S010.

Council of Science Editors:

Tran THC. La reconnaissance des objets et des scènes naturelles dans la dégénérescence maculaire liée à l’âge : Objects and scene recognition in Age-Related Macular Degenration. [Doctoral Dissertation]. Université Lille II – Droit et Santé 2011. Available from: http://www.theses.fr/2011LIL2S010

Georgia State University

25. Cheng, Qi. Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008.

Degree: MPH, 2014, Georgia State University

URL: https://scholarworks.gsu.edu/iph_theses/344

► ABSTRACT IMPORTANCE: Age-related macular degeneration (AMD) is a leading cause of low vision in elderly population. The association of vascular and renal conditions has… (more)

▼ ABSTRACT IMPORTANCE: Age-related macular degeneration (AMD) is a leading cause of low vision in elderly population. The association of vascular and renal conditions has been reported inconsistently. Unfolding the association may provide the insight to eye care providers to take account general health management into eye care. OBJECTIVES: To investigate the prevalence of the vascular and renal comorbidities with AMD, examine the association of a single or combination of these comorbidities with AMD. DSIGN AND PARTICIPANTS: Population-base cross-sectional study involved the adults aged 40 years or older (N=4596) who participated in the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES), a national representative population-based survey of non-institutionalized US residents. MAIN OUTCOMES AND MEASURES: AMD was defined by the presence of drusen and presence of pigmental abnormality. Angina pectoris (AP), coronary heart disease (CHD), congestive heart failure (CHF) and myocardial infarction (MI), and stroke, assessed by self-report by the questionnaire of medical conditions, Chronic kidney disease (CKD), assessed by self-report and estimation of glomerular filtration rate (GFR) and the level of urine albumin. Heart disease (HD) was defined as having AP or CHF or CHD or MI. RESULTS: Among individuals with AMD, 6% had AP, 10% had CHD, 7% had CHF, 10% had MI, 13% had stroke, and 29% had CKD. The weighted prevalence of these conditions were significantly higher than those without AMD (All P-values CONCLUSION AND RELEVANCE: These findings from the nationally-representative sample of the US population highlight the prevalence of vascular and renal comorbidities associated with AMD, the modest evidence of relationship of each single comorbidity, and strong association of combination of stroke and CKD to AMD independent of age, gender, and other factors. Because of the cross-sectional design, the results of this study can not address a causal relationship between AMD and the examined comorbidities. It is unclear whether AMD and comorbidities arise from individual predisposition to vascular and renal diseases or whether complications from these morbidities increase the risk of AMD. However, the important caveat is that preventive and care management for the examined comorbidities may lessen the severity of symptoms or prevent AMD. Advisors/Committee Members: Richard Rothernberg MD, MPH, Jinan Saddine MD, MPH, Dora ll'yasova Ph.D.

Subjects/Keywords: Age-related macular degeneration; Comorbidities; Heart disease; Stroke; Chronic kidney disease

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APA (6^th Edition):

Cheng, Q. (2014). Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008. (Thesis). Georgia State University. Retrieved from https://scholarworks.gsu.edu/iph_theses/344

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cheng, Qi. “Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008.” 2014. Thesis, Georgia State University. Accessed February 28, 2021. https://scholarworks.gsu.edu/iph_theses/344.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cheng, Qi. “Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008.” 2014. Web. 28 Feb 2021.

Vancouver:

Cheng Q. Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008. [Internet] [Thesis]. Georgia State University; 2014. [cited 2021 Feb 28]. Available from: https://scholarworks.gsu.edu/iph_theses/344.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cheng Q. Age-related Macular Degeneration and Vascular and Renal Comorbidities in Adults Aged 40 Years or Older: NHANES 2005-2008. [Thesis]. Georgia State University; 2014. Available from: https://scholarworks.gsu.edu/iph_theses/344

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Virginia Tech

26. Hirani, Anjali A. Corticosteroid-Encapsulated Nanoparticles in Thermoreversible Gels for the Amelioration of Choroidal Neovascularization in Age-Related Macular Degeneration.

Degree: PhD, Biomedical Engineering, 2015, Virginia Tech

URL: http://hdl.handle.net/10919/73318

► Age-related macular degeneration (AMD) is one of the leading causes of blindness in adults over the age of 60. Currently, at least 11 million patients… (more)

▼ Age-related macular degeneration (AMD) is one of the leading causes of blindness in adults over the age of 60. Currently, at least 11 million patients in the United States have some form of macular degeneration and this number is projected to grow as the population ages. The more severe form of the disease – neovascular (wet) AMD, is characterized by intraocular neovascularization, inflammation, and retinal damage; however, the disease progression can be deterred through intraocular injections of anti-angiogenic agents. The complications and burden that arise from repetitive injections as well as the difficulty posed by targeting the posterior segment of the eye make this an interesting territory for the development of novel drug delivery systems. New methods for drug delivery are being investigated exploring the use of nanoparticles and other polymeric materials. The goal of this project is to study the potential use of poly(lactide-co-glycolic acid)-polyethylene glycol (PLGA-PEG) nanoparticles in thermoreversible gels as localized sustained intraocular drug delivery. We prepared stable and reproducible corticosteroid-encapsulated nanoparticles in thermoreversible gels to inhibit vascular endothelial growth factor (VEGF) overexpression characteristic of neovascular AMD. We characterized the drug delivery system by obtaining size, shape, and drug encapsulation data. We also demonstrated that the polymer could be injected into the vitreous as a solution and transition to a gel phase based on the temperature difference between regular indoor environment and the vitreous body. The drug delivery system was tested on human retinal pigment epithelial cells (ARPE-19), for cytotoxicity, uptake and VEGF expression. We also examined the drug delivery system's ability to mitigate the disease progression in a mouse model of choroidal neovascularization (CNV). The effect on blood vessel area was shown and the changes in the mRNA expression of angiogenesis mediators were analyzed by real-time reverse transcription polymerase chain reaction (RT-PCR). These results indicate that the proposed drug delivery systems has the promise to be developed for retinal diseases, involving CNV, including neovascular AMD. Further studies are warranted in developing this promising intraocular drug delivery system for wet AMD and similar ophthalmic diseases. Advisors/Committee Members: Lee, Yong Woo (committeechair), Achenie, Luke E. K. (committeechair), Li, Liwu (committee member), Goldstein, Aaron S. (committee member), Pathak, Yashwant (committee member), Sutariya, Vijaykumar B. (committee member).

Subjects/Keywords: Choroidal Neovascularization; Age-Related Macular Degeneration; Sustained Drug Delivery

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hirani, A. A. (2015). Corticosteroid-Encapsulated Nanoparticles in Thermoreversible Gels for the Amelioration of Choroidal Neovascularization in Age-Related Macular Degeneration. (Doctoral Dissertation). Virginia Tech. Retrieved from http://hdl.handle.net/10919/73318

Chicago Manual of Style (16^th Edition):

Hirani, Anjali A. “Corticosteroid-Encapsulated Nanoparticles in Thermoreversible Gels for the Amelioration of Choroidal Neovascularization in Age-Related Macular Degeneration.” 2015. Doctoral Dissertation, Virginia Tech. Accessed February 28, 2021. http://hdl.handle.net/10919/73318.

MLA Handbook (7^th Edition):

Hirani, Anjali A. “Corticosteroid-Encapsulated Nanoparticles in Thermoreversible Gels for the Amelioration of Choroidal Neovascularization in Age-Related Macular Degeneration.” 2015. Web. 28 Feb 2021.

Vancouver:

Hirani AA. Corticosteroid-Encapsulated Nanoparticles in Thermoreversible Gels for the Amelioration of Choroidal Neovascularization in Age-Related Macular Degeneration. [Internet] [Doctoral dissertation]. Virginia Tech; 2015. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10919/73318.

Council of Science Editors:

Hirani AA. Corticosteroid-Encapsulated Nanoparticles in Thermoreversible Gels for the Amelioration of Choroidal Neovascularization in Age-Related Macular Degeneration. [Doctoral Dissertation]. Virginia Tech; 2015. Available from: http://hdl.handle.net/10919/73318

Duke University

27. Landowski, Michael. Unraveling the in vivo Effect of the AMD-risk Associated CFH H402 Variant .

Degree: 2018, Duke University

URL: http://hdl.handle.net/10161/17509

► Age-related macular degeneration (AMD) is a complex retinal degeneration present in elderly populations of first world countries with limited available therapeutic interventions. Risk for… (more)

▼ Age-related macular degeneration (AMD) is a complex retinal degeneration present in elderly populations of first world countries with limited available therapeutic interventions. Risk for AMD is strongly conferred by advanced aging but is also modulated by genetic variants and environmental stresses. One of the most replicated genetic variants associated with AMD is the Complement Factor H (CFH) Y402H polymorphism. CFH is a critical regulator of the complement cascade but how the H402 variant impairs its function and contributes to AMD development is unclear. Herein, the role of the H402 variant in the development of AMD-like pathologies was interrogated using two different mouse models based on advanced aging, CFH perturbation and environmental stress. First, aged CFH hemizygous knockout (Cfh+/-) mice were fed a high fat, cholesterol-enriched (HFC) diet for eight weeks to induce AMD-like pathologies such as vision loss, increased retinal pigmented epithelium (RPE) damage, increased sub-RPE deposit formation and immune cell recruitment to the RPE/choroid interface. To determine if the recruitment of immune cells drives the formation of the AMD-like pathologies in aged Cfh+/-~HFC mice, aged Cfh+/- mice were concurrently treated with a systemic anti-C5a therapy during the eight week HFC diet treatment to block the complement-mediated recruitment of immune cells to the eye. However, the ocular phenotype was unchanged in aged Cfh+/-~HFC mice treated with the anti-C5a therapy despite the decrease of recruited immune cells to the posterior eye. This data suggests the risk associated with the H402 CFH variant is not solely attributable to complement-mediated immune cell recruitment to the posterior eye. Second, aged transgenic mice expressing equal concentrations of the normal human CFH Y402 (CFH-Y:Cfh-/-) or risk-associated CFH H402 (CFH-HH:Cfh-/-) protein were fed an eight week HFC diet. Remarkably, vision loss, increased RPE damage and increased sub-RPE deposit formation was only observed in aged CFH-HH:Cfh-/- mice following diet treatment. Biochemical analysis of aged CFH:Cfh-/- mice revealed differences in plasma and ocular lipoproteins, but not complement, between aged CFH-Y:Cfh-/-~HFC and CFH-HH:Cfh-/-~HFC mice. Thus, we targeted plasma lipoprotein levels through dietary intervention in aged CFH-HH:Cfh-/- mice and observed visual loss in these mice that coincided with dietary cholesterol-induced increases of plasma LDL. Based on our findings we hypothesize that the risk-associated with the H402 CFH variant and AMD is due to the interaction of CFH with lipoproteins and not its complement regulatory roles. These new insights may help explain why current therapies targeting complement inhibition for AMD have failed and, importantly, support targeting lipoprotein metabolism, as a treatment for AMD. Advisors/Committee Members: Bowes Rickman, Catherine (advisor).

Subjects/Keywords: Ophthalmology; Aging; Genetics; age-related macular degeneration; complement; lipoprotein; mice

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Landowski, M. (2018). Unraveling the in vivo Effect of the AMD-risk Associated CFH H402 Variant . (Thesis). Duke University. Retrieved from http://hdl.handle.net/10161/17509

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Landowski, Michael. “Unraveling the in vivo Effect of the AMD-risk Associated CFH H402 Variant .” 2018. Thesis, Duke University. Accessed February 28, 2021. http://hdl.handle.net/10161/17509.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Landowski, Michael. “Unraveling the in vivo Effect of the AMD-risk Associated CFH H402 Variant .” 2018. Web. 28 Feb 2021.

Vancouver:

Landowski M. Unraveling the in vivo Effect of the AMD-risk Associated CFH H402 Variant . [Internet] [Thesis]. Duke University; 2018. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10161/17509.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Landowski M. Unraveling the in vivo Effect of the AMD-risk Associated CFH H402 Variant . [Thesis]. Duke University; 2018. Available from: http://hdl.handle.net/10161/17509

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

28. Pead, Emma Jean Roberta. Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging.

Degree: PhD, 2020, University of Edinburgh

URL: https://doi.org/10.7488/era/516 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.814890

► The eye is embryologically, physiologically and anatomically linked to the brain. Emerging evidence suggests that neurodegenerative diseases, such as Alzheimer’s disease (AD), manifest in the… (more)

▼ The eye is embryologically, physiologically and anatomically linked to the brain. Emerging evidence suggests that neurodegenerative diseases, such as Alzheimer’s disease (AD), manifest in the retina. Retinal imaging is a quick, non-invasive method to view the retina and its microvasculature. Features such as blood vessel calibre, tortuosity and complexity of the vascular structure (measured through fractal analysis) are thought to reflect microvascular health and have been found to associate with clinical signs of hypertension, diabetes, cardiovascular disease and cognitive decline. Small deposits of acellular debris called drusen in the peripheral retina have also been linked with AD where histological studies show they can contain amyloid beta, a hallmark of AD. Age-related macular degeneration (AMD) is a neurodegenerative disorder of the retina and a leading cause of irreversible vision loss in the ageing population. Increasing number and size of drusen is a characteristic of AMD disease progression. Ultra-widefield (UWF) retinal imaging with a scanning laser ophthalmoscope captures up to 80% of the retina in a single acquisition allowing a larger area of the retina to be assessed for signs of neurodegeneration than is possible with a conventional fundus camera, particularly the periphery. Quantification of changes to the microvasculature and drusen load could be used to derive early biomarkers of diseases that have vascular and neurodegenerative components such as AD and other forms of dementia. Manually grading drusen in UWF images is a difficult, subjective and a time-consuming process because the area imaged is large (around 700mm2) and drusen appear as small spots (< 125μm). An automatic approach to detecting drusen would overcome these challenges and facilitate investigations into drusen as a biomarker of neurodegeneration. In this thesis, an automatic system inspired by the recent successes of deep learning in medical image analysis was developed. As drusen are abundant in the retinas of people with AMD, a neural network was trained to classify patches in such a dataset of UWF images. This was compared to the manual gradings of two human observers. There was only a moderate agreement between observers (Kappa = 0.53, Average Dice Similarity Coefficient (DSC) = 0.38), reflecting the challenging and difficult nature of manually grading drusen in UWF images. Performances achieved for the automatic system (assessed using the area under curve (AUC) performance statistic) were 0.55-0.59, 0.62- 0.65 and 0.65-0.66 in the central, perimacular and peripheral regions of the retina, respectively. Highest performance was observed in a subset 8 images where observer agreement was at its highest (DSC > 0.8 and < 0.9), achieving AUC 0.55-0.59, 0.78-0.82 and 0.82-0.85 in the central, perimacular and peripheral zones, respectively. Measurements of the retinal vasculature appearing in UWF images of cognitively healthy (CH) individuals and patients diagnosed with mild cognitive impairment (MCI) and AD were obtained using a…

Subjects/Keywords: age-related macular degeneration; neurodegeneration; retinal imaging; Alzheimer's disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pead, E. J. R. (2020). Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging. (Doctoral Dissertation). University of Edinburgh. Retrieved from https://doi.org/10.7488/era/516 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.814890

Chicago Manual of Style (16^th Edition):

Pead, Emma Jean Roberta. “Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging.” 2020. Doctoral Dissertation, University of Edinburgh. Accessed February 28, 2021. https://doi.org/10.7488/era/516 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.814890.

MLA Handbook (7^th Edition):

Pead, Emma Jean Roberta. “Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging.” 2020. Web. 28 Feb 2021.

Vancouver:

Pead EJR. Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging. [Internet] [Doctoral dissertation]. University of Edinburgh; 2020. [cited 2021 Feb 28]. Available from: https://doi.org/10.7488/era/516 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.814890.

Council of Science Editors:

Pead EJR. Assessing neurodegeneration of the retina and brain with ultra-widefield retinal imaging. [Doctoral Dissertation]. University of Edinburgh; 2020. Available from: https://doi.org/10.7488/era/516 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.814890

Miami University

29. Zeng, Ziqian. Fabrication and Development of a PCL Electrospun Fiber - Keratin Aerogel Scaffold to Mimic Bruch’s Membrane for the Study of Age-related Macular Degeneration.

Degree: MS, Chemical, Paper & Biomedical Engineering, 2017, Miami University

URL: http://rave.ohiolink.edu/etdc/view?acc_num=miami1502103996594191

► Age-related Macular Degeneration (AMD) is a retinal disease responsible for 8.7% of blindness globally, and it is predicted that 196 million people will be affected… (more)

Subjects/Keywords: Biomedical Engineering; Electrospinning; Keratin aerogel; Age-related macular Degeneration

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APA (6^th Edition):

Zeng, Z. (2017). Fabrication and Development of a PCL Electrospun Fiber - Keratin Aerogel Scaffold to Mimic Bruch’s Membrane for the Study of Age-related Macular Degeneration. (Masters Thesis). Miami University. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=miami1502103996594191

Chicago Manual of Style (16^th Edition):

Zeng, Ziqian. “Fabrication and Development of a PCL Electrospun Fiber - Keratin Aerogel Scaffold to Mimic Bruch’s Membrane for the Study of Age-related Macular Degeneration.” 2017. Masters Thesis, Miami University. Accessed February 28, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1502103996594191.

MLA Handbook (7^th Edition):

Zeng, Ziqian. “Fabrication and Development of a PCL Electrospun Fiber - Keratin Aerogel Scaffold to Mimic Bruch’s Membrane for the Study of Age-related Macular Degeneration.” 2017. Web. 28 Feb 2021.

Vancouver:

Zeng Z. Fabrication and Development of a PCL Electrospun Fiber - Keratin Aerogel Scaffold to Mimic Bruch’s Membrane for the Study of Age-related Macular Degeneration. [Internet] [Masters thesis]. Miami University; 2017. [cited 2021 Feb 28]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1502103996594191.

Council of Science Editors:

Zeng Z. Fabrication and Development of a PCL Electrospun Fiber - Keratin Aerogel Scaffold to Mimic Bruch’s Membrane for the Study of Age-related Macular Degeneration. [Masters Thesis]. Miami University; 2017. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=miami1502103996594191

University of Georgia

30. Renzi, Lisa Marie. Non-invasive assessment of retinal carotenoids as a biomarker of overall health status.

Degree: 2014, University of Georgia

URL: http://hdl.handle.net/10724/22768

► The purpose of this investigation was to examine the utility of measures of macular pigment optical density (MPOD) as a biomarker of systemic wellness. Forty-nine… (more)

Subjects/Keywords: macular pigment; age-related macular degeneration; age-related cataract; heart disease; serum lipids; blood pressure; triglycerides; lipoproteins; ageing; macular pigment optical density; biomarker; wellness

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APA (6^th Edition):

Renzi, L. M. (2014). Non-invasive assessment of retinal carotenoids as a biomarker of overall health status. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/22768

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Renzi, Lisa Marie. “Non-invasive assessment of retinal carotenoids as a biomarker of overall health status.” 2014. Thesis, University of Georgia. Accessed February 28, 2021. http://hdl.handle.net/10724/22768.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Renzi, Lisa Marie. “Non-invasive assessment of retinal carotenoids as a biomarker of overall health status.” 2014. Web. 28 Feb 2021.

Vancouver:

Renzi LM. Non-invasive assessment of retinal carotenoids as a biomarker of overall health status. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Feb 28]. Available from: http://hdl.handle.net/10724/22768.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Renzi LM. Non-invasive assessment of retinal carotenoids as a biomarker of overall health status. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/22768

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Open Access Theses and Dissertations