You searched for subject:(Adjuvants).
Showing records 1 – 30 of
201 total matches.
◁ [1] [2] [3] [4] [5] [6] [7] ▶
1.
Mairaj Ahmed Ansari.
Characterization of some immunogenic proteins and their
potential as vaccine candidates; -.
Degree: Biotechnology, 2011, Aligarh Muslim University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/11412 
► Treating regimen against intracellular pathogens has been a challenge to scientific community because of their inhabitant priorities. Those infections not only infect range of host…
(more)
▼ Treating regimen against intracellular pathogens
has been a challenge to scientific community because of their
inhabitant priorities. Those infections not only infect range of
host cells but also escape from circulating antibodies. Being
intracellular, it is very difficult to completely remove them from
the host system and require specific dosage regimen for their
treatment. Beside, most antibiotics are also marred with hurdles
like side effects, cost, availability in the market, schedule of
administration. Moreover emergence of multidrug resistance strains
due to overuse of antibiotics especially in case of tuberculosis
and other intracellular pathogens has restricted their use.
Extensive drug resistance is a menace to be handled by available
antibiotics which thus makes the treatment more complex and
complicated, keeping into consideration the fact that prevention is
a preferred option over treatment, it is an urgent requirement to
develop vaccine against intracellular pathogens. Generation of
protective immunity against many pathogens requires fine adjustment
between humoral and cell mediated immunity. Circulating antibodies
play crucial role in the elimination of extracellular infections,
however majority of intracellular infections (e.g. L.
newlinemonocytogenes, M. tuberculosis, malaria, leishmaniasis,
candidiasis etc.) require generation of CD8+ cytotoxic T-cells
(CTL) in conjunction to strong CD4+ T-helper cells (Th) because
such pathogens adapt intracellular parasitism as a strategy to
avoid recognition by antibodies. Vaccine development against
intracellular pathogens is very complicated as intracellular
pathogens adapt different mechanisms to protect themselves from
host immune system, some of them being capable to modulate the
immune system e.g. inhibition of antibody production
(L.monocytogenes, S. typhimurium, N. meningitis), interfere with
antigen processing by antigen presenting cells (APCs) (L.
monocytogenes, S. typhimurium), inhibition of lymphocyte
proliferation (H. pylori, M. leprae, L.
monocytogenes
References p. 117-144
Advisors/Committee Members: Owais, M.
Subjects/Keywords: Biotechnology; immunogenic proteins; infections; adjuvants
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ansari, M. A. (2011). Characterization of some immunogenic proteins and their
potential as vaccine candidates; -. (Thesis). Aligarh Muslim University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/11412
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ansari, Mairaj Ahmed. “Characterization of some immunogenic proteins and their
potential as vaccine candidates; -.” 2011. Thesis, Aligarh Muslim University. Accessed January 16, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/11412.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ansari, Mairaj Ahmed. “Characterization of some immunogenic proteins and their
potential as vaccine candidates; -.” 2011. Web. 16 Jan 2021.
Vancouver:
Ansari MA. Characterization of some immunogenic proteins and their
potential as vaccine candidates; -. [Internet] [Thesis]. Aligarh Muslim University; 2011. [cited 2021 Jan 16].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11412.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ansari MA. Characterization of some immunogenic proteins and their
potential as vaccine candidates; -. [Thesis]. Aligarh Muslim University; 2011. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/11412
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Saskatchewan
2.
Magiri, Royford Bundi 1983-.
INNATE IMMUNE RESPONSES ACTIVATED BY THE ADJUVANT POLY [DI (SODIUM CARBOXYLATOETHYLPHENOXY)PHOSPHAZENE](PCEP) IN PIGS.
Degree: 2019, University of Saskatchewan
URL: http://hdl.handle.net/10388/12208
► ABSTRACT Adjuvants are critical components of vaccines because they enhance antigen-specific immune responses to protect against disease. However, the mechanisms of action (MOA) of most…
(more)
▼ ABSTRACT
Adjuvants are critical components of vaccines because they enhance antigen-specific immune responses to protect against disease. However, the mechanisms of action (MOA) of most
adjuvants are not well understood and they particularly are under-investigated in large animal species including pigs and cattle. This knowledge gap may limit our ability to design effective vaccines for livestock. Understanding the mechanisms by which
adjuvants mediate their effects could provide critical information on how innate immunity influences the development of adaptive immunity. Furthermore, knowledge on the MOA of
adjuvants may inform vaccine the safety. In the present investigations, we studied the MOA of the experimental adjuvant polydi(sodium carboxylatoethylphenoxy)phosphazene (PCEP) in pigs. First, we administered PCEP by intradermal (i.d.) injection into pigs and assessed its impact on the expression of select immune response genes known as ‘adjuvant response genes’ over time. We observed that PCEP induced the expression of chemokine (C-C motif) ligand 2 (CCL-2), proinflammatory cytokine interleukin (IL)-6, IL-13 and macrophage scavenger receptor 1 (MSR1) genes at the site of injection. Next, we evaluated whether these gene expressions translate to protein transcription by accessing local and systemic production of cytokines after intradermal injection of PCEP into piglets and whether the cytokines produced induces recruitment of immune cells at the site of injection and in the draining lymph nodes. We observed that, at the site of injection, PCEP induced increased production of IL-1β and IL-13 cytokines, increased cellular infiltration of macrophages, T and B cells, and other leucocytes especially neutrophils as well as showing necrotic debris which might cause release of damage associated molecular patterns (DAMPs) and activate the inflammasome. In the draining lymph nodes, the cytokines IL-1β and IL-6 were elevated and there was increased leucocyte infiltration. No changes in cytokine levels were detected in the blood after PCEP injection indicating that the immunostimulatory effect of PCEP is local but not systemic.
Because i.d. injection of PCEP induced signs of necrosis (cell death), we investigated whether reduction of the adjuvant dose reduced tissue damage without negatively impacting antigen-specific immune responses. We conducted two studies to address this issue. In the first study, we injected piglets i.d with varying doses of PCEP alone as follows: 500 μg, 100 μg, or 20 μg PCEP into piglets and evaluated the inflammatory responses. The four parameters evaluated were granuloma formation, lymphocytic infiltration, necrosis, and suppurative inflammation at the injection site and the draining lymph nodes over 14 days. When PCEP was injected alone, we observed that only 500 μg consistently induced significant necrosis and suppurative inflammation. However, the medium dose (100 μg) PCEP did induce significant skin granulomas and lymphocyte infiltration, where as the only significant response induced in…
Advisors/Committee Members: Mutwiri, George, Wilson, Heather, Tikoo, Suresh, Huang, Yanyun, Singh, Baljit, Gomis, Susantha.
Subjects/Keywords: Innate immunity and adjuvants
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Magiri, R. B. 1. (2019). INNATE IMMUNE RESPONSES ACTIVATED BY THE ADJUVANT POLY [DI (SODIUM CARBOXYLATOETHYLPHENOXY)PHOSPHAZENE](PCEP) IN PIGS. (Thesis). University of Saskatchewan. Retrieved from http://hdl.handle.net/10388/12208
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Magiri, Royford Bundi 1983-. “INNATE IMMUNE RESPONSES ACTIVATED BY THE ADJUVANT POLY [DI (SODIUM CARBOXYLATOETHYLPHENOXY)PHOSPHAZENE](PCEP) IN PIGS.” 2019. Thesis, University of Saskatchewan. Accessed January 16, 2021.
http://hdl.handle.net/10388/12208.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Magiri, Royford Bundi 1983-. “INNATE IMMUNE RESPONSES ACTIVATED BY THE ADJUVANT POLY [DI (SODIUM CARBOXYLATOETHYLPHENOXY)PHOSPHAZENE](PCEP) IN PIGS.” 2019. Web. 16 Jan 2021.
Vancouver:
Magiri RB1. INNATE IMMUNE RESPONSES ACTIVATED BY THE ADJUVANT POLY [DI (SODIUM CARBOXYLATOETHYLPHENOXY)PHOSPHAZENE](PCEP) IN PIGS. [Internet] [Thesis]. University of Saskatchewan; 2019. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10388/12208.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Magiri RB1. INNATE IMMUNE RESPONSES ACTIVATED BY THE ADJUVANT POLY [DI (SODIUM CARBOXYLATOETHYLPHENOXY)PHOSPHAZENE](PCEP) IN PIGS. [Thesis]. University of Saskatchewan; 2019. Available from: http://hdl.handle.net/10388/12208
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
3.
Decout, Alexiane.
Bases moléculaires et conséquences fonctionnelles de l'interaction entre les mycobactéries et les lectines de type C Mincle, Dectine-1 et Dectine-2 : Molecular bases and functional consequences of the interaction between mycobacteria and the C-type lectins Mincle, Dectin-1 and Dectin-2.
Degree: Docteur es, Biologie structurale et fonctionnelle, 2015, Université Toulouse III – Paul Sabatier
URL: http://www.theses.fr/2015TOU30224
► La tuberculose humaine, causée par Mycobacterium tuberculosis, est responsable de plus d'un million de décès par an et on estime qu'un tiers de la population…
(more)
▼ La tuberculose humaine, causée par Mycobacterium tuberculosis, est responsable de plus d'un million de décès par an et on estime qu'un tiers de la population mondiale est infecté de façon latente. Lors de leur arrivée dans les poumons, les mycobactéries sont détectées par les cellules du système immunitaire inné grâce à de nombreux récepteurs, tels que les lectines de type C. Le but de mes travaux était de caractériser les bases moléculaires et les conséquences fonctionnelles des interactions entre les mycobactéries et trois lectines de type C : Mincle, Dectine-1 et Dectine-2. Nous avons ainsi défini les relations structure/fonction de la reconnaissance des ligands de nature glycolipidique par Mincle et Dectine-2 et synthétisé des ligands de structure minimale de Mincle qui pourraient avoir de potentielles applications comme adjuvants de vaccination. Enfin, nous avons identifié Dectine-1 comme une possible voie d'entrée silencieuse des mycobactéries dans les cellules phagocytaires.
Mycobacterium tuberculosis is the causative agent of human tuberculosis leading to more than 1 million deaths every year and infecting latently one third of the population worldwide. Once in the lungs, mycobacteria are detected by innate immune cells through several pattern recognition receptors such as C-type lectins. The aim of my thesis was to characterize the molecular bases and the functional consequences mycobacteria recognition by three C-type lectins: Mincle, Dectin-1 and Dectin-2. We have characterized the structure/function relationships of the glycolipid ligands recognition by Mincle and Dectin-2 and synthesized ligands of Mincle with a minimal structure that could be used as vaccine adjuvants inducing Th1 and Th17 responses. We also identified Dectin-1 as a possible silent entry gate for mycobacteria into phagocytic cells allowing binding to immune cells without triggering intracellular signaling.
Advisors/Committee Members: Nigou, Jérôme (thesis director), Tiraby, Gérard (thesis director).
Subjects/Keywords: Mycobactéries; Immunitée innée; Lectines; Adjuvants
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Decout, A. (2015). Bases moléculaires et conséquences fonctionnelles de l'interaction entre les mycobactéries et les lectines de type C Mincle, Dectine-1 et Dectine-2 : Molecular bases and functional consequences of the interaction between mycobacteria and the C-type lectins Mincle, Dectin-1 and Dectin-2. (Doctoral Dissertation). Université Toulouse III – Paul Sabatier. Retrieved from http://www.theses.fr/2015TOU30224
Chicago Manual of Style (16th Edition):
Decout, Alexiane. “Bases moléculaires et conséquences fonctionnelles de l'interaction entre les mycobactéries et les lectines de type C Mincle, Dectine-1 et Dectine-2 : Molecular bases and functional consequences of the interaction between mycobacteria and the C-type lectins Mincle, Dectin-1 and Dectin-2.” 2015. Doctoral Dissertation, Université Toulouse III – Paul Sabatier. Accessed January 16, 2021.
http://www.theses.fr/2015TOU30224.
MLA Handbook (7th Edition):
Decout, Alexiane. “Bases moléculaires et conséquences fonctionnelles de l'interaction entre les mycobactéries et les lectines de type C Mincle, Dectine-1 et Dectine-2 : Molecular bases and functional consequences of the interaction between mycobacteria and the C-type lectins Mincle, Dectin-1 and Dectin-2.” 2015. Web. 16 Jan 2021.
Vancouver:
Decout A. Bases moléculaires et conséquences fonctionnelles de l'interaction entre les mycobactéries et les lectines de type C Mincle, Dectine-1 et Dectine-2 : Molecular bases and functional consequences of the interaction between mycobacteria and the C-type lectins Mincle, Dectin-1 and Dectin-2. [Internet] [Doctoral dissertation]. Université Toulouse III – Paul Sabatier; 2015. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2015TOU30224.
Council of Science Editors:
Decout A. Bases moléculaires et conséquences fonctionnelles de l'interaction entre les mycobactéries et les lectines de type C Mincle, Dectine-1 et Dectine-2 : Molecular bases and functional consequences of the interaction between mycobacteria and the C-type lectins Mincle, Dectin-1 and Dectin-2. [Doctoral Dissertation]. Université Toulouse III – Paul Sabatier; 2015. Available from: http://www.theses.fr/2015TOU30224
4.
GORMAN, AOIFE LOUISE LOUISE.
Modulation of macrophage responses by the vaccine adjuvant alum.
Degree: School of Biochemistry & Immunology. Discipline of Biochemistry, 2020, Trinity College Dublin
URL: http://hdl.handle.net/2262/92267
► Recent findings have challenged the classical view of innate versus adaptive immunity, suggesting that innate cells can retain some memory of past immunological insults. This…
(more)
▼ Recent findings have challenged the classical view of innate versus adaptive immunity, suggesting that innate cells can retain some memory of past immunological insults. This trained immunity which allows for primed cellular responses to secondary infections is independent of T and B cells and is mediated by innate cells such as monocytes and macrophages. While it has been shown that certain live vaccines such as BCG can induce trained immunity, the training effects of non-living vaccines incorporating the widely used vaccine adjuvant alum have not been addressed. Alum has been predominantly used in several childhood vaccines due to effectiveness in promoting antibody responses and robust safety profile. However, the immunomodulatory effects of alum have not been fully elucidated. Using the in vitro model of training, alum was found to train innate cells to adopt a distinct morphology in addition to an increased capacity to proliferate through enhanced metabolic activity. The transcriptional profile of alum-trained macrophages was explored using the NanoString Inflammation panel one week after training in vitro. Alum globally downregulated pro-inflammatory gene expression while a small group of upregulated genes was identified which may shed light on the mechanisms underlying the establishment of these unconventional anti-inflammatory macrophages. One such gene, Il1rn, that encodes IL-1Ra, the natural inhibitor of the pro-inflammatory cytokine IL1-?, was significantly increased in response to alum alone. Interestingly, secretion of this anti- inflammatory cytokine was hindered by pre-treatment with rapamycin. Furthermore, the metabolic profile of macrophages stimulated with alum was reversed by rapamycin. These data suggest that stimulating macrophages with alum may favour a pro-resolution phenotype via activation of mammalian target of rapamycin (mTOR), altering cellular metabolism and proliferative capacity.
Advisors/Committee Members: Lavelle, Edward.
Subjects/Keywords: Innate Training; Adjuvants; Macrophages; Immunology
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
GORMAN, A. L. L. (2020). Modulation of macrophage responses by the vaccine adjuvant alum. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/92267
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
GORMAN, AOIFE LOUISE LOUISE. “Modulation of macrophage responses by the vaccine adjuvant alum.” 2020. Thesis, Trinity College Dublin. Accessed January 16, 2021.
http://hdl.handle.net/2262/92267.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
GORMAN, AOIFE LOUISE LOUISE. “Modulation of macrophage responses by the vaccine adjuvant alum.” 2020. Web. 16 Jan 2021.
Vancouver:
GORMAN ALL. Modulation of macrophage responses by the vaccine adjuvant alum. [Internet] [Thesis]. Trinity College Dublin; 2020. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2262/92267.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
GORMAN ALL. Modulation of macrophage responses by the vaccine adjuvant alum. [Thesis]. Trinity College Dublin; 2020. Available from: http://hdl.handle.net/2262/92267
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Université de Sherbrooke
5.
Piotte, Martin.
Caractérisation du poly(naphtalènesulfonate) : influence de son contre-ion et de sa masse molaire sur son interaction avec le ciment.
Degree: 1993, Université de Sherbrooke
URL: http://savoirs.usherbrooke.ca/handle/11143/4944
► Nous avons cherché à mieux comprendre les mécanismes d'interaction entre un superplastifiant : le poly(naphtalenesulfonate) (PNS) et le ciment. La première étape de notre étude…
(more)
▼ Nous avons cherché à mieux comprendre les mécanismes d'interaction entre un superplastifiant : le poly(naphtalenesulfonate) (PNS) et le ciment. La première étape de notre étude a été d'explorer et développer des méthodes de caractérisation du mélange polymérique. La chromatographie liquide à haute performance (CLHP) par formation de paires d'ions a donné une bonne séparation ; plus de vingt pics ont été détectés. Les techniques de résonance magnétique nucléaire, de spectrophotométrie UV, de diffusion de la lumière, d'osmométrie et de viscosité ont été utilisés en vue d'obtenir davantage de renseignements sur la composition du mélange. Le fractionnement par ultrafiltration et par précipitation sélective a permis l'étude de différentes portions du PNS. Afin d'en préciser l'interprétation, les données de caractérisation ont été couplées aux informations disponibles sur les mécanismes des réactions de polycondensation. Cet exercice a permis notamment de mettre en relief la relation entre certaines procédures de synthèse et la composition du mélange produit. Nos données indiquent que la majorité des mélanges étudiés contient des oligomères, des PNS linéaires de taille moyenne (degré de polymérisation compris entre 5 et 20) et des PNS ramifiés. Ces fortes présomptions n'ont cependant pas été confirmées par des mesures structurales directes.
Advisors/Committee Members: [non identifié] (advisor).
Subjects/Keywords: Ciment; Adjuvants
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Piotte, M. (1993). Caractérisation du poly(naphtalènesulfonate) : influence de son contre-ion et de sa masse molaire sur son interaction avec le ciment. (Doctoral Dissertation). Université de Sherbrooke. Retrieved from http://savoirs.usherbrooke.ca/handle/11143/4944
Chicago Manual of Style (16th Edition):
Piotte, Martin. “Caractérisation du poly(naphtalènesulfonate) : influence de son contre-ion et de sa masse molaire sur son interaction avec le ciment.” 1993. Doctoral Dissertation, Université de Sherbrooke. Accessed January 16, 2021.
http://savoirs.usherbrooke.ca/handle/11143/4944.
MLA Handbook (7th Edition):
Piotte, Martin. “Caractérisation du poly(naphtalènesulfonate) : influence de son contre-ion et de sa masse molaire sur son interaction avec le ciment.” 1993. Web. 16 Jan 2021.
Vancouver:
Piotte M. Caractérisation du poly(naphtalènesulfonate) : influence de son contre-ion et de sa masse molaire sur son interaction avec le ciment. [Internet] [Doctoral dissertation]. Université de Sherbrooke; 1993. [cited 2021 Jan 16].
Available from: http://savoirs.usherbrooke.ca/handle/11143/4944.
Council of Science Editors:
Piotte M. Caractérisation du poly(naphtalènesulfonate) : influence de son contre-ion et de sa masse molaire sur son interaction avec le ciment. [Doctoral Dissertation]. Université de Sherbrooke; 1993. Available from: http://savoirs.usherbrooke.ca/handle/11143/4944
6.
Burakova, Yulia.
Design of
emulsion-based adjuvants for animal vaccines.
Degree: PhD, Department of Chemical
Engineering, 2018, Kansas State University
URL: http://hdl.handle.net/2097/39340
► Vaccination is one of the most essential steps in controlling and preventing economically important infectious diseases in livestock. Vaccines need to be effective at producing…
(more)
▼ Vaccination is one of the most essential steps in
controlling and preventing economically important infectious
diseases in livestock. Vaccines need to be effective at producing a
high level of immune responses that protect the animal from future
encounters with infectious agents. Additional requirements for
veterinary vaccines include safety, inexpensive components, and
feasibility for large-scale production. These factors make
emulsions attractive vaccine
adjuvants. The use of emulsions as
adjuvants (substances that help to amplify the immune responses to
the antigen) has been explored for decades. However, emulsions are
commonly produced with expensive and energy-demanding devices which
impact the price of the adjuvant, therefore, affecting the price of
the vaccines.
This study examined low-energy emulsification
methods to meet the requirements for a simple and low-cost vaccine
manufacture that avoided utilizing complicated equipment.
Spontaneous emulsification (SE) and phase inversion composition
(PIC) was explored to formulate stable emulsions with nanometer
droplet sizes. The study on the impact of oil composition on the
formation of emulsions produced by SE revealed that addition of
medium-chain triglycerides into the oil phase is beneficial for
droplet size reduction and stability of emulsions. Box-Behnken
design (BBD) was used to develop mathematical relationships between
formulation variables and droplet size, polydispersity, zeta
potential, and stability of emulsions formulated via SE. The BBD
allowed the study of a simultaneous effect of multiple variables
and formulate emulsions with certain physical characteristics, an
effect that suggested that there was a more effective approach in
designing complex systems like emulsions.
New
adjuvants containing
mixtures of oils and surfactants were developed to produce
emulsions with nanoscale droplet diameters and multiple
water-in-oil-in-water structures via the
PIC approach. The strong
antibody responses and the absence of injection site side effects
were observed in animals that received emulsion vaccines with
experimental
adjuvants.
Additionally, inexpensive food-grade
saponin extract was examined for stabilizing and increasing
immunostimulatory activity of oil-in-water emulsion-based
adjuvants. The
adjuvants demonstrated high immune responses in pigs
after co-administration with a subunit protein antigen.
Advisors/Committee Members: John R. SchlupJishu N. Shi.
Subjects/Keywords: Emulsions; Vaccine
adjuvants; Veterinary
vaccines
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Burakova, Y. (2018). Design of
emulsion-based adjuvants for animal vaccines. (Doctoral Dissertation). Kansas State University. Retrieved from http://hdl.handle.net/2097/39340
Chicago Manual of Style (16th Edition):
Burakova, Yulia. “Design of
emulsion-based adjuvants for animal vaccines.” 2018. Doctoral Dissertation, Kansas State University. Accessed January 16, 2021.
http://hdl.handle.net/2097/39340.
MLA Handbook (7th Edition):
Burakova, Yulia. “Design of
emulsion-based adjuvants for animal vaccines.” 2018. Web. 16 Jan 2021.
Vancouver:
Burakova Y. Design of
emulsion-based adjuvants for animal vaccines. [Internet] [Doctoral dissertation]. Kansas State University; 2018. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2097/39340.
Council of Science Editors:
Burakova Y. Design of
emulsion-based adjuvants for animal vaccines. [Doctoral Dissertation]. Kansas State University; 2018. Available from: http://hdl.handle.net/2097/39340
Université de Sherbrooke
7.
Gagné, Pierre.
Chaleur d'hydratation initiale de ciments en présence de divers adjuvants.
Degree: 1993, Université de Sherbrooke
URL: http://hdl.handle.net/11143/16995
► L'objectif de ce travail est de mieux comprendre l'effet des superplastifiants et de divers autres additifs sur les réactions initiales d'hydratation du ciment et de…
(more)
▼ L'objectif de ce travail est de mieux comprendre l'effet des superplastifiants et de divers autres additifs sur les réactions initiales d'hydratation du ciment et de matériaux apparentés. Cette étude a été faite par calorimétrie d'immersion, à des rapports eau/ciment (E/C) élevés. Nous avons développé un calorimètre permettant au ciment et l'eau d'avoir la même température, puis d'enregistrer en continu les variations de température dès l'introduction du ciment dans l'eau. L'acquisition et le traitement des données sont fait au moyen d'un ordinateur. Plusieurs matériaux hydrauliques ont été étudiés: divers ciments, un clinker et les principales phases pures du ciment ( C₃S, C₂S, C₃A, C₄AF). Les ciments ont été choisis de façon à pouvoir varier certains paramètres, dont la surface spécifique et la composition, particulièrement la teneur en C₃A. L'effet de la température sur la chaleur initiale d'hydratation dans l'eau pure a été mesuré pour deux ciments. Les superplastifiants utilisés ont été les polynaphtalènesulfonates de sodium (PNS-Na) et de Calcium (PNS-Ca) et e polymélamine sulfonate de sodium (PMS-Na). Ces produits étaient d'origine commerciale. Dans le cas du PNS-Na, nous avons également utilisé des fractions de différente masse molaire; ces fractions ont été obtenues par précipitation sélective dans divers mélanges de solvants. Les autres produits étudiés ont été un réducteur d'eau (plastifiant): le lignosulfonate, et des additifs inorganiques: CaSO₄•2H₂O, CaSO₄ • ½H₂O, Na₂SO₄ , Ca(OH)₂ et NaOH. Des mesures de chaleur l'hydratation initiale ont également été faites sur les mélanges de ces additifs inorganiques avec le PNS-Na. Les résultats montrent qu'en général, la présence de superplastifiants dans l'eau diminue la chaleur d'hydratation initiale des ciments, et ralentit de façon significative la vitesse d'hydratation initiale. Les mélanges commerciaux de PNS-Na et PNS-Ca ainsi que les fractions de PNS-Na de masse molaire élevée diminuent légèrement la chaleur initiale d'hydratation (20%); par contre, le PNS-Na de masse molaire faible, le PMS-Na et les lignosulfonates font chuter cette chaleur d'environ 45%. Les études sur le clinker et sur les phases pures montrent que le superplastifiant agit principalement sur la phase C₃A . Il diminue la chaleur d'hydratation initiale du C₃A et du clinker de la même façon que le qypse.
Advisors/Committee Members: Jolicoeur, Carmel (advisor).
Subjects/Keywords: Ciment; Adjuvants
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Gagné, P. (1993). Chaleur d'hydratation initiale de ciments en présence de divers adjuvants. (Masters Thesis). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/16995
Chicago Manual of Style (16th Edition):
Gagné, Pierre. “Chaleur d'hydratation initiale de ciments en présence de divers adjuvants.” 1993. Masters Thesis, Université de Sherbrooke. Accessed January 16, 2021.
http://hdl.handle.net/11143/16995.
MLA Handbook (7th Edition):
Gagné, Pierre. “Chaleur d'hydratation initiale de ciments en présence de divers adjuvants.” 1993. Web. 16 Jan 2021.
Vancouver:
Gagné P. Chaleur d'hydratation initiale de ciments en présence de divers adjuvants. [Internet] [Masters thesis]. Université de Sherbrooke; 1993. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11143/16995.
Council of Science Editors:
Gagné P. Chaleur d'hydratation initiale de ciments en présence de divers adjuvants. [Masters Thesis]. Université de Sherbrooke; 1993. Available from: http://hdl.handle.net/11143/16995
Université de Sherbrooke
8.
Nkinamubanzi, Pierre-Claver.
Influence des dispersants polymériques (superplastifiants) sur les suspensions concentrées et les pâtes de ciment.
Degree: 1993, Université de Sherbrooke
URL: http://hdl.handle.net/11143/17001
► Les dispersants polymériques des bétons, dits superplastifiants, augmentent de façon spectaculaire la fluidité de ces matériaux et en améliorent diverses propriétés. Cependant les mécanismes d'action…
(more)
▼ Les dispersants polymériques des bétons, dits superplastifiants, augmentent de façon spectaculaire la fluidité de ces matériaux et en améliorent diverses propriétés. Cependant les mécanismes d'action impliqués dans la fluidification demeurent nébuleux. L'objectif de ce projet est de contribuer à l'élucidation des mécanismes de fluidification de ces dispersants. Comme l'élément de loin le plus actif des bétons est le ciment, nous avons étudié l'influence de quelques superplastifiants sur l'hydratation et le comportement rhéologique de divers ciments portland. Le ciment étant un matériau fort complexe, nous avons choisi des matériaux de référence, inertes chimiquement, que nous avons utilisés pour réaliser les mesures d'isothermes d'adsorption, de potentiel zêta et de rhéologie. Ceci nous permettait de nous affranchir de la complexité chimique des ciments et des réactions d'hydratation. Toutes les suspensions étudiées sont fluidifiées par le superplastifiant choisi, à savoir le polynaphtalène sulfonate de sodium, (PNS-Na). La présence de sels alcalins ou alcalino-terreux augmente énormément la viscosité des suspensions, ce qui entraîne une demande plus importante en superplastifiant. Nos résultats montrent qu'une bonne corrélation existe entre la valeur du potentiel zêta des particules en suspension, la quantité de polymère adsorbée et le comportement rhéologique observé. Les mesures d'isothermes d'adsorption du PNS-Na et de trois de ses fractions de différentes masses molaires, séparées par ultrafiltration, sur ces matériaux indiquent clairement que les fractions de plus hautes masses molaires sont plus adsorbées que les oligomères. Aussi, les fractions de plus hautes masses molaires sont plus efficaces quand il s'agit de fluidifier les suspensions concentrées et les coulis de ciment. Cependant il existe une limite de masse molaire au dessus de laquelle la taille du polymère n'a plus d'effet. Pour évaluer l'influence des superplastifiants sur les ciments, nous avons mis au point un calorimètre permettant de mesurer la chaleur dégagée par un coulis de ciment pendant les premières 24 heures d'hydratation. Des paramètres reliés à la durée de la période dormante, aux flux de chaleur maximaux et à la chaleur totale dégagée indiquent des comportements cinétiques différents quand on change de ciment (la composition chimique) et quand on change le contre-ion du superplastifiant. Cette étude indique cependant qu'une fois la période dormante terminée, les réactions d'hydratation se déroulent normalement. Les tests de fluidité effectués sur ces coulis indiquent des divergences de comportement quand on change de ciment ou de superplastifiant. A la lumière de nos résultats, les mécanismes de fluidification des suspensions concentrées et des bétons frais peuvent être envisagés: en s'adsorbant sur les particules en suspension, les superplastifiants en modifient les propriétés interfaciales en induisant une charge fortement négative sur leur surface. Les particules portant ainsi une charge identique se repoussent. Aussi la présence…
Advisors/Committee Members: Jolicoeur, Carmel (advisor).
Subjects/Keywords: Ciment; Adjuvants
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nkinamubanzi, P. (1993). Influence des dispersants polymériques (superplastifiants) sur les suspensions concentrées et les pâtes de ciment. (Doctoral Dissertation). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/17001
Chicago Manual of Style (16th Edition):
Nkinamubanzi, Pierre-Claver. “Influence des dispersants polymériques (superplastifiants) sur les suspensions concentrées et les pâtes de ciment.” 1993. Doctoral Dissertation, Université de Sherbrooke. Accessed January 16, 2021.
http://hdl.handle.net/11143/17001.
MLA Handbook (7th Edition):
Nkinamubanzi, Pierre-Claver. “Influence des dispersants polymériques (superplastifiants) sur les suspensions concentrées et les pâtes de ciment.” 1993. Web. 16 Jan 2021.
Vancouver:
Nkinamubanzi P. Influence des dispersants polymériques (superplastifiants) sur les suspensions concentrées et les pâtes de ciment. [Internet] [Doctoral dissertation]. Université de Sherbrooke; 1993. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11143/17001.
Council of Science Editors:
Nkinamubanzi P. Influence des dispersants polymériques (superplastifiants) sur les suspensions concentrées et les pâtes de ciment. [Doctoral Dissertation]. Université de Sherbrooke; 1993. Available from: http://hdl.handle.net/11143/17001
Northeastern University
9.
Shah, Ruchi Rudraprasad.
Development of a self-emulsification process for emulsion adjuvants and the effect of droplet size on vaccine response.
Degree: PhD, School of Pharmacy, 2016, Northeastern University
URL: http://hdl.handle.net/2047/D20213419
► Vaccines have evolved from using attenuated viruses beginning in 1935, to using inactivated viruses, toxoids and now to using subunit and recombinant proteins. Subunit proteins…
(more)
▼ Vaccines have evolved from using attenuated viruses beginning in 1935, to using inactivated viruses, toxoids and now to using subunit and recombinant proteins. Subunit proteins use viral antigens (fragments) to generate protective immunity, and as such are less immunogenic compared to attenuated or inactivated (whole) viral vaccines. As a result, adjuvants are added to subunit vaccines, to improve their effectiveness by enhancing and sustaining immune responses, reducing the dose of antigen needed, enhancing the breadth of the immune response, increasing the immunological memory associated with the adaptive immune system, and decreasing the frequency of vaccination. Adjuvants developed to enhance immune responses include aluminum hydroxide compounds (alum), emulsions, virosomes, liposomes, and ISCOMs. In the last few decades considerable attention has been focused on lipid-based adjuvants for use in vaccines - for example, squalene oil-in-water emulsions as adjuvants have been extensively studied. Currently two emulsion adjuvants are added to commercially marketed influenza vaccines: MF59 and AS03 with many more in pre-clinical and clinical studies - GLA-SE, WEC50, AF03, AF04, etc. Emulsion adjuvants promote or enhance T-cell responses, which are typically absent after recombinant protein immunization, and have been used successfully for flu prevention in a diverse group of patients for flu, from pediatric to geriatric and from healthy individuals to immune-compromised individuals. Even though adjuvanted flu vaccines are commercially successful, the mechanism of action of these added agents is not clearly understood. This lack of understanding is a key hindrance in adjuvant development, which in turn holds back vaccine development in general.
Subjects/Keywords: adjuvants; vaccine; Immunological adjuvants; Drug delivery systems; Emulsions; Vaccines; Drops; Nanoparticles
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Shah, R. R. (2016). Development of a self-emulsification process for emulsion adjuvants and the effect of droplet size on vaccine response. (Doctoral Dissertation). Northeastern University. Retrieved from http://hdl.handle.net/2047/D20213419
Chicago Manual of Style (16th Edition):
Shah, Ruchi Rudraprasad. “Development of a self-emulsification process for emulsion adjuvants and the effect of droplet size on vaccine response.” 2016. Doctoral Dissertation, Northeastern University. Accessed January 16, 2021.
http://hdl.handle.net/2047/D20213419.
MLA Handbook (7th Edition):
Shah, Ruchi Rudraprasad. “Development of a self-emulsification process for emulsion adjuvants and the effect of droplet size on vaccine response.” 2016. Web. 16 Jan 2021.
Vancouver:
Shah RR. Development of a self-emulsification process for emulsion adjuvants and the effect of droplet size on vaccine response. [Internet] [Doctoral dissertation]. Northeastern University; 2016. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2047/D20213419.
Council of Science Editors:
Shah RR. Development of a self-emulsification process for emulsion adjuvants and the effect of droplet size on vaccine response. [Doctoral Dissertation]. Northeastern University; 2016. Available from: http://hdl.handle.net/2047/D20213419
10.
Genard, Romain.
Rôle du facteur de transcription Nrf2 dans l'immunomodulation induit par les adjuvants vaccinaux : Role of the transcription factor Nrf2 in immunomodulation induce by vaccine adjuvants.
Degree: Docteur es, Toxicologie, 2015, Université Paris-Saclay (ComUE)
URL: http://www.theses.fr/2015SACLS230
► Les adjuvants vaccinaux permettent d’augmenter la réponse immunitaire dirigée contre un antigène donné. Certains de ces adjuvants miment des signaux de danger, tels que des…
(more)
▼ Les adjuvants vaccinaux permettent d’augmenter la réponse immunitaire dirigée contre un antigène donné. Certains de ces adjuvants miment des signaux de danger, tels que des agonistes des récepteurs de l’immunité, les récepteurs Toll-like (TLR) ou les récepteurs NOD-like (NLR), et permettent une activation des cellules dendritiques (DC). Les DC sont essentielles dans la mise en place d’une réponse adaptative contre un antigène : elles acquièrent un phénotype mature, contrôlé par les voies des MAPK et NF-κB, permettant la présentation de l’antigène aux lymphocyte T et l’initiation d’une réponse spécifique. La voie Nrf2/Keap1, impliquée principalement dans la détoxication des xénobiotiques et le contrôle du stress oxydant, peut être activée en réponse à des agonistes des TLR tels que le LPS (agoniste TLR 4). Nous avons mis en évidence qu’un traitement par le R848 (agoniste TLR7/8) ou le MDP (agoniste NOD2) induit la transcription des gènes cibles de Nrf2 dans les DC murines. Nrf2 participe également à la production de cytokines inflammatoires en réponse au LPS et au R848 et jouet un rôle dans la prolifération lymphocytaire induite par les DC pré-traitées avec le MDP. Par ailleurs, Nrf2 contrôle la réponse anticorps spécifiques de l’antigène chez la souris. L’injection d’anatoxine tétanique induit une production d’anticorps plus élevé chez la souris déficiente nrf2 par rapport aux souris sauvages. Cette augmentation de la production d’anticorps est corrélée avec une augmentation du nombre de lymphocyte B dans la moelle osseuse et la rate.
Vaccine adjuvants are able to boost immune response toward antigens when there are simultaneously injected. Some of these adjuvant mimic danger signals, such as Toll like receptors (TLR) agonists or NOD-like receptors agonists, required for dendritic cell (DC) activation. DC are essentiales for adaptative immune response against antigens : they acquire mature phenotype, controlled by MAPK and NF-kB signaling pathway, leading to antigen presentation and specific immune response. The Nrf2/keap1 signaling pathway, mainly involves in xenobiotics detoxication and oxidative stress control, can be activate by TLR agonists, such as LPS (TLR 4 agonist).We showed that R848 (TLR 7/8 agonist) and MDP (NOD2 agonist) could induce Nrf2’s target genes transcription in murines dendritic cells (BMDC). Nrf2 seems also to be part of inflammatory cytokines production in response to LPS or R848 and modulated T lymphocyte proliferation induced by MDP pre-treated BMDC. Moreover, Nrf2 appears to play a role in specific antibodies response against an antigen in mice. . In fact, Tetanus toxoid (TT) injection induces higher titer of antibodies anti-TT in nrf2-/- mice compared to nrf2+/+ mice. This increase is also correlated with more specific B lymphocytes in bone marrow and spleen after TT immunisation.
Advisors/Committee Members: Pallardy, Marc (thesis director), Kerdine-Rômer, Saadia (thesis director).
Subjects/Keywords: Nrf2; Adjuvants; Vaccin; Cellule Dendritique; Nrf2; Adjuvants; Vaccine; Dendritic cell
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Genard, R. (2015). Rôle du facteur de transcription Nrf2 dans l'immunomodulation induit par les adjuvants vaccinaux : Role of the transcription factor Nrf2 in immunomodulation induce by vaccine adjuvants. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2015SACLS230
Chicago Manual of Style (16th Edition):
Genard, Romain. “Rôle du facteur de transcription Nrf2 dans l'immunomodulation induit par les adjuvants vaccinaux : Role of the transcription factor Nrf2 in immunomodulation induce by vaccine adjuvants.” 2015. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed January 16, 2021.
http://www.theses.fr/2015SACLS230.
MLA Handbook (7th Edition):
Genard, Romain. “Rôle du facteur de transcription Nrf2 dans l'immunomodulation induit par les adjuvants vaccinaux : Role of the transcription factor Nrf2 in immunomodulation induce by vaccine adjuvants.” 2015. Web. 16 Jan 2021.
Vancouver:
Genard R. Rôle du facteur de transcription Nrf2 dans l'immunomodulation induit par les adjuvants vaccinaux : Role of the transcription factor Nrf2 in immunomodulation induce by vaccine adjuvants. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2015. [cited 2021 Jan 16].
Available from: http://www.theses.fr/2015SACLS230.
Council of Science Editors:
Genard R. Rôle du facteur de transcription Nrf2 dans l'immunomodulation induit par les adjuvants vaccinaux : Role of the transcription factor Nrf2 in immunomodulation induce by vaccine adjuvants. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2015. Available from: http://www.theses.fr/2015SACLS230
Université Catholique de Louvain
11.
Art, Jean-François.
Quartz crystal microbalance sensors to elucidate interaction mechanisms between antigens and aluminum-based vaccine adjuvants.
Degree: 2018, Université Catholique de Louvain
URL: http://hdl.handle.net/2078.1/207780
► Vaccines are produced from antigenic subunits, such as proteins, which are poorly immunogenic, i.e. they fail to trigger a sufficient immune response and a memory…
(more)
▼ Vaccines are produced from antigenic subunits, such as proteins, which are poorly immunogenic, i.e. they fail to trigger a sufficient immune response and a memory effect, especially in children. The immunostimulation capacity of most vaccines is enhanced thanks to vaccine adjuvants, among which aluminum hydroxide (AH) is the most widely used. Antigen adsorption on AH adjuvant particles has been identified as an important step to produce effective vaccines. Controlling antigen-AH interactions is thus a key challenge in vaccine formulation. The aim of this work was to develop a new platform, based on quartz crystal microbalance (QCM), to monitor directly and in real time the adsorption of proteins, taken as model antigens, on adjuvant particles. The addressed challenges were (i) to assemble AH particles at the surface of QCM sensors into thin, continuous and stable layers, and (ii) to use these AH-modified sensors for the measurement of protein adsorption in different pH and ionic strength conditions, with a view to unravel adsorption mechanisms. The modified sensors were successfully elaborated with two different commercial AH adjuvants. The immobilized AH particle layers were thin (20-80 nm thick), stable under different pH and saline conditions, and reached a high surface coverage on the QCM sensors. The adsorption results revealed that bovine serum albumin (BSA) adsorption was not exclusively driven by electrostatic interactions at physiological pH. Moreover, the role of PO4-OH ligand exchanges was highlighted in the adsorption of ovalbumin, as well as in BSA adsorption, despite the fact that the latter has a low phosphate content. The two different AH adjuvants behaved differently towards protein adsorption, even though their physicochemical properties were similar. The immobilization of adjuvant particles on QCM sensors offers a new platform for the study of antigen adsorption, to the benefit of vaccine formulation, and also enriches the range of applications for which QCM can be exploited, especially in colloid science.
(AGRO - Sciences agronomiques et ingénierie biologique) – UCL, 2018
Advisors/Committee Members: UCL - SST/IMCN/BSMA - Bio and soft matter, UCL - Ingénierie biologique, agronomique et environnementale, Devaux, Jacques, Dekeyser, Caroline, Francius, Grégory, Gaigneaux, Eric, Préat, Véronique, Dupont-Gillain, Christine.
Subjects/Keywords: Quartz crystal microbalance; Aluminum-based adjuvants; Vaccines
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Art, J. (2018). Quartz crystal microbalance sensors to elucidate interaction mechanisms between antigens and aluminum-based vaccine adjuvants. (Thesis). Université Catholique de Louvain. Retrieved from http://hdl.handle.net/2078.1/207780
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Art, Jean-François. “Quartz crystal microbalance sensors to elucidate interaction mechanisms between antigens and aluminum-based vaccine adjuvants.” 2018. Thesis, Université Catholique de Louvain. Accessed January 16, 2021.
http://hdl.handle.net/2078.1/207780.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Art, Jean-François. “Quartz crystal microbalance sensors to elucidate interaction mechanisms between antigens and aluminum-based vaccine adjuvants.” 2018. Web. 16 Jan 2021.
Vancouver:
Art J. Quartz crystal microbalance sensors to elucidate interaction mechanisms between antigens and aluminum-based vaccine adjuvants. [Internet] [Thesis]. Université Catholique de Louvain; 2018. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2078.1/207780.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Art J. Quartz crystal microbalance sensors to elucidate interaction mechanisms between antigens and aluminum-based vaccine adjuvants. [Thesis]. Université Catholique de Louvain; 2018. Available from: http://hdl.handle.net/2078.1/207780
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Hong Kong
12.
方朗茵.
Immunomodulatory
properties of probiotic bacteria.
Degree: 2013, University of Hong Kong
URL: http://hdl.handle.net/10722/208173
► Probiotics are living microorganisms, which when administered in adequate amounts confer a health benefit on the host. They have been reported to relieve acute diarrhoea,…
(more)
▼ Probiotics are living microorganisms, which
when administered in adequate amounts confer a health benefit on
the host. They have been reported to relieve acute diarrhoea,
atopic dermatitis and irritable bowel syndrome in disease-specific
animal studies and in human intervention trials. However,
probiotics are regularly consumed by general healthy population
with limited knowledge in the immunomodulation of probiotics of
local and systemic immune responses in healthy experimental models.
Serving as the first line of defense against microbial infections
and the largest immunological organ in animal host, the epithelium
lining the small and large intestine is supposed to be the first
organ to encounter probiotics as probiotics are always orally
taken. It is believed that probiotics regulate the local immunities
in the gut, which acts as the pivot in modulating the systemic
immune responses. Accordingly, it was hypothesized that probiotic
bacteria can modulate both local and systemic immune responses in
healthy population; and the immunomodulation of combination of
probiotics is different from that of individual strains. Wildtype
healthy C57BL/6 mice were fed with different probiotic strains −
Lactobacillus rhamnosus GG (LGG), Lactobacillus rhamnosus LC705
(LC705), Bifidobacterium breve Bb99 (Bb99), Propionibacterium
freudenreichii ssp. shermanii JS (PJS) or Escherichia coli Nissle
1917 (EcN), or mixture of probiotics − GGmix (LGG, LC705, Bb99 and
PJS) and ECPJSmix (PJS and EcN), for three weeks. After that,
intestine, liver, spleen and blood were investigated. Probiotics
suppressed intestinal T helper (Th)17 immune response but enhanced
systemic (hepatic and splenic) Th17 immune response, suggesting
that immune homeostasis was maintained in healthy individuals.
Mechanism of action of LGG was further studied in this project as
LGG is the widely studied probiotics. It was hypothesized that LGG
exerts immunomodulatory effects by bacteria cells and/or its
derived soluble factors such as lactic acid. Immunomodulatory
effects of LGG cells and their soluble factors on dendritic cells
(DCs), macrophages and monocytes from healthy blood donors were
investigated as antigen-presenting cells (APCs) are pivots of
bridging innate and adaptive immunities. Cytokine secretion
profile, expressions of toll-like receptors (TLRs) and
activation-related receptors of the APCs were examined. Both LGG
cells and their soluble factors promoted type 1-responsiveness
while soluble factors promoted type 17-responsiveness as well. Yet,
lactic acid seemed not to be the one which enhanced type 1 and type
17 immune responses in soluble factors. With better understanding
on the immunomodulation of probiotics in healthy models,
prophylactic efficacy of probiotics in preventing infections and
diseases can be availed.
Subjects/Keywords: Immunological adjuvants;
Probiotics
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
方朗茵. (2013). Immunomodulatory
properties of probiotic bacteria. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/208173
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
方朗茵. “Immunomodulatory
properties of probiotic bacteria.” 2013. Thesis, University of Hong Kong. Accessed January 16, 2021.
http://hdl.handle.net/10722/208173.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
方朗茵. “Immunomodulatory
properties of probiotic bacteria.” 2013. Web. 16 Jan 2021.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
方朗茵. Immunomodulatory
properties of probiotic bacteria. [Internet] [Thesis]. University of Hong Kong; 2013. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10722/208173.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
方朗茵. Immunomodulatory
properties of probiotic bacteria. [Thesis]. University of Hong Kong; 2013. Available from: http://hdl.handle.net/10722/208173
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
University of Guelph
13.
Langdon, Nicole M.
Evaluation of the fit of Tolpyralate for Weed Management in Field Corn (Zea mays L.) in Ontario.
Degree: MS, 2020, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17882
► Thirty-six experiments were conducted over two years (2018, 2019) to evaluate tolpyralate, a benzoylpyrazole 4-hydroxyphenyl-pyruvate dioxygenase inhibitor, for weed management in corn in Ontario. The…
(more)
▼ Thirty-six experiments were conducted over two years (2018, 2019) to evaluate tolpyralate, a benzoylpyrazole 4-hydroxyphenyl-pyruvate dioxygenase inhibitor, for weed management in corn in Ontario. The importance of
adjuvants (MSO and UAN) with tolpyralate + atrazine and the influence of Roundup Weathermax® was determined for control of nine annual weed species, glyphosate-resistant (GR) Canada fleabane and GR waterhemp. Optimal control was achieved with tolpyralate + atrazine + MSO and when tolpyralate + atrazine was co-applied with Roundup Weathermax®. Tolpyralate and tolpyralate + atrazine has residual activity on GR Canada fleabane, comparable to current industry standards. Three weed species exhibited a time-of-day effect to tolpyralate + atrazine, although, consistent control was achieved regardless of application time. Corn injury was greatest from tolpyralate + atrazine when applied at the 2X rate alone and/or co-applied with glyphosate at 1 WAA; there was no further increase in corn injury when co-applied with glyphosate.
Advisors/Committee Members: Sikkema, Peter H. (advisor).
Subjects/Keywords: tolpyralate; Canada Fleabane; waterhemp; adjuvants; weed control
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Langdon, N. M. (2020). Evaluation of the fit of Tolpyralate for Weed Management in Field Corn (Zea mays L.) in Ontario. (Masters Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17882
Chicago Manual of Style (16th Edition):
Langdon, Nicole M. “Evaluation of the fit of Tolpyralate for Weed Management in Field Corn (Zea mays L.) in Ontario.” 2020. Masters Thesis, University of Guelph. Accessed January 16, 2021.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17882.
MLA Handbook (7th Edition):
Langdon, Nicole M. “Evaluation of the fit of Tolpyralate for Weed Management in Field Corn (Zea mays L.) in Ontario.” 2020. Web. 16 Jan 2021.
Vancouver:
Langdon NM. Evaluation of the fit of Tolpyralate for Weed Management in Field Corn (Zea mays L.) in Ontario. [Internet] [Masters thesis]. University of Guelph; 2020. [cited 2021 Jan 16].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17882.
Council of Science Editors:
Langdon NM. Evaluation of the fit of Tolpyralate for Weed Management in Field Corn (Zea mays L.) in Ontario. [Masters Thesis]. University of Guelph; 2020. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/17882
Université de Sherbrooke
14.
Manai, Khaled.
Étude de l'effet d'ajouts chimiques et minéraux sur la maniabilité, la stabilité et les performances des bétons autonivelants.
Degree: 1995, Université de Sherbrooke
URL: http://hdl.handle.net/11143/17415
► De plus en plus, les structures en béton armé deviennent complexes et très ferraillées. Afin que ces structures puissent accomplir le rôle pour lequel elles…
(more)
▼ De plus en plus, les structures en béton armé deviennent complexes et très ferraillées. Afin que ces structures puissent accomplir le rôle pour lequel elles ont été conçues, il est essentiel d'assurer une mise en place parfaite du béton dans les coffrages. Ceci est assuré par l'utilisation de moyens de vibrations adéquats ou par un béton à matrice très déformable mais stable (pas de risque de ségrégation ou de ressuage excessifs). Cette étude a pour objectif le développement d'une série de bétons fluides autonivelants (E/C = 0,41) présentant une fluidité élevée (étalement= 650 ± 20 mm) mais aussi de bonne résistances au lessivage, à la sédimentation et au ressuage. Ces bétons comportent divers ajouts minéraux et
adjuvants chimiques comme de la fumée silice, une cendre volante, un laitier, un agent colloïdal et un superplastifiant. Ils ont été soumis des essais de compression, de mesure de module élastique, du retrait, du fluage, de gel-dégel, de la perméabilité aux ions chlore et à l'adhérence béton-armatures. Les résultats obtenus montrent que l'on peut fabriquer des bétons fluides ayant une bonne maniabilité mais aussi une bonne cohésion. Ces bétons donnent de bonnes résistances mécaniques et peuvent développer, dans le cas des bétons à air entraîné avec un réseau de bulles d'air adéquat, de meilleures résistances à l'action des cycles de gel-dégel et à l'écaillage des surfaces (facteur de durabilité supérieur à 80). La présente étude a permis aussi de mettre en évidence l'effet fluidifiant des particules de laitier mais aussi leur action néfaste sur la résistance au lessivage des bétons. Certains dosages en ajouts minéraux (3% fumée de silice, 20% cendre volante) ont permis aussi d'améliorer l'ouvrabilité des bétons pour des teneurs en granulats et en ajouts chimiques et minéraux fixes. On a pu déduire également, l'apport bénéfique de l'agent colloïdal sur le contrôle de la stabilité volumétrique des bétons frais, c'est à dire, la réduction de la sédimentation et du ressuage dans le béton. L'analyse des performances mécaniques in-situ a montré que les bétons optimisés testés à l'adhérence avec les barres d'armatures ont présenté des variations de la contrainte d'adhérence (top-bar effect), selon la hauteur, plus faibles que les limites supérieures recommandées par certains codes et spécifications. Les variations de la résistance à la compression et du module élastique selon la hauteur des structures étaient aussi minimes.
Advisors/Committee Members: Khayat, Kamal H. (advisor).
Subjects/Keywords: Béton Adjuvants; Béton
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Manai, K. (1995). Étude de l'effet d'ajouts chimiques et minéraux sur la maniabilité, la stabilité et les performances des bétons autonivelants. (Masters Thesis). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/17415
Chicago Manual of Style (16th Edition):
Manai, Khaled. “Étude de l'effet d'ajouts chimiques et minéraux sur la maniabilité, la stabilité et les performances des bétons autonivelants.” 1995. Masters Thesis, Université de Sherbrooke. Accessed January 16, 2021.
http://hdl.handle.net/11143/17415.
MLA Handbook (7th Edition):
Manai, Khaled. “Étude de l'effet d'ajouts chimiques et minéraux sur la maniabilité, la stabilité et les performances des bétons autonivelants.” 1995. Web. 16 Jan 2021.
Vancouver:
Manai K. Étude de l'effet d'ajouts chimiques et minéraux sur la maniabilité, la stabilité et les performances des bétons autonivelants. [Internet] [Masters thesis]. Université de Sherbrooke; 1995. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11143/17415.
Council of Science Editors:
Manai K. Étude de l'effet d'ajouts chimiques et minéraux sur la maniabilité, la stabilité et les performances des bétons autonivelants. [Masters Thesis]. Université de Sherbrooke; 1995. Available from: http://hdl.handle.net/11143/17415
Université de Sherbrooke
15.
Beaulieu, Jacques.
Étude de caractérisation de bétons contenant du ciment type 20 M avec et sans fumée de silice.
Degree: 1995, Université de Sherbrooke
URL: http://hdl.handle.net/11143/17571
► Plusieurs recherches ont été effectuées sur l'effet de la fumée de silice avec différents types de ciment dont les types 10 et 30, mais pas…
(more)
▼ Plusieurs recherches ont été effectuées sur l'effet de la fumée de silice avec différents types de ciment dont les types 10 et 30, mais pas à date avec le ciment type 20M. Le ciment type 20M est un ciment spécial à basse chaleur d'hydratation utilisé au Québec depuis les années 1960 par Hydro-Québec et depuis les années 1970 par la Société d'Énergie de la Baie James pour la construction des aménagements hydro électriques. Ce mémoire de maîtrise a pour but de comparer les caractéristiques de bétons fabriqués avec le ciment type 20M seulement à celles d'autres bétons fabriqués en remplaçant 8,5 % de ce ciment par de la fumée de silice. La fumée de silice améliore certaines caractéristiques du béton dont la maniabilité au rapport E/L de 0,25, la résistance à la compression pour les bétons avec des rapports E/L de 0,5 5 et 0,65, la perméabilité à l'eau et la perméabilité aux ions chlore. Pour d'autres caractéristiques, la fumée de silice peut être considérée comme un désavantage, tels que la demande en eau qui est légèrement augmentée pour les bétons sans superplastifiant, le ressuage qui est fortement réduit, la température d'hydratation qui est augmentée légèrement et la résistance à. l'écaillage qui est diminuée fortement pour les rapports E/L de 0,45 à 0,65. Pour les autres caractéristiques, les effets de la fumée de silice sont faibles ou non significatifs.
Advisors/Committee Members: Aïtcin, Pierre-Claude (advisor), Tagnit-Hamou, Arezki (advisor).
Subjects/Keywords: Béton; Adjuvants; Ciment
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Beaulieu, J. (1995). Étude de caractérisation de bétons contenant du ciment type 20 M avec et sans fumée de silice. (Masters Thesis). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/17571
Chicago Manual of Style (16th Edition):
Beaulieu, Jacques. “Étude de caractérisation de bétons contenant du ciment type 20 M avec et sans fumée de silice.” 1995. Masters Thesis, Université de Sherbrooke. Accessed January 16, 2021.
http://hdl.handle.net/11143/17571.
MLA Handbook (7th Edition):
Beaulieu, Jacques. “Étude de caractérisation de bétons contenant du ciment type 20 M avec et sans fumée de silice.” 1995. Web. 16 Jan 2021.
Vancouver:
Beaulieu J. Étude de caractérisation de bétons contenant du ciment type 20 M avec et sans fumée de silice. [Internet] [Masters thesis]. Université de Sherbrooke; 1995. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11143/17571.
Council of Science Editors:
Beaulieu J. Étude de caractérisation de bétons contenant du ciment type 20 M avec et sans fumée de silice. [Masters Thesis]. Université de Sherbrooke; 1995. Available from: http://hdl.handle.net/11143/17571
University of British Columbia
16.
de Jong, Susan Rachel Dean.
Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides.
Degree: PhD, Biochemistry and Molecular Biology, 2007, University of British Columbia
URL: http://hdl.handle.net/2429/353
► Immunostimulatory oligodeoxynucleotides (ODN) containing unmethylated CpG motifs are powerful stimulators of innate as well as adaptive immune responses, exerting their activity through the triggering of…
(more)
▼ Immunostimulatory oligodeoxynucleotides (ODN) containing unmethylated CpG motifs are powerful stimulators of innate as well as adaptive immune responses, exerting their activity through the triggering of the endosomally localized TLR9 by a poorly understood mechanism. The immunopotency and broad range of activity of CpG ODN makes it a promising immunotherapeutic for the treatment and prevention of cancer and other diseases. However, rapid degradation of ODN by serum nucleases, low levels of accumulation in target tissue and lack of specificity for and poor uptake into target cells following systemic administration pose significant hurdles for the clinical application of CpG ODN. This thesis describes the immunostimulatory properties of CpG ODN encapsulated in liposomal nanoparticles (LN), a delivery system that overcomes many of the problems impeding the clinical development of "free" ODN. In particular, it is shown that LN delivery of CpG ODN specifically targets the ODN for uptake by immune cells in vivo, providing a basis for significantly enhanced immunostimulatory activity, including more potent innate and adaptive immune responses, that ultimately improve anti-tumour efficacy.
A particular focus of this thesis concerns previous observations that methylated sequences in ODN (mCpG ODN) are immunologically inert. It is shown that encapsulation of mCpG ODN in LN results in immunostimulatory activity that is equal to or greater than that observed for LN formulations of the equivalent unmethylated form as judged by various immune parameters and anti-tumour efficacy. Further, it is shown that both LN-mCpG ODN and LN-CpG ODN exert their immunostimulatory effects via TLR9 based on preliminary in vitro results and confirmed by studies performed in TLR9 knockout animals.
The mechanisms responsible for the differentiation between both CpG ODN and mCpGODN and how encapsulation endows immunostimulatory potential are explored. It is shown that discrimination occurs upstream of TLR9 and that the lack of immunological activity of free mCpG ODN is not due to differences in uptake, trafficking to endosomal compartments or ability to bind to TLR9, when compared with CpG ODN, but rather due to its ability to colocalize with TLR9 in the endosomal compartment. It is proposed that whereas the uptake of free CpG ODN results in the induction of the Src Family Kinase signalling cascade which mediates the migration of TLR9 from the ER to the late endosome, the uptake of free mCpGODN does not. However, it is suggested that encapsulation bypasses the methylation specific recognition of CpG ODN, allowing for the activation of SFK signalling resulting in subsequent co-localization of TLR9 and mCpG ODN in the endosome thus initiating immunostimulatory activity.
Subjects/Keywords: liposomes; adjuvants; cancer
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
de Jong, S. R. D. (2007). Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides. (Doctoral Dissertation). University of British Columbia. Retrieved from http://hdl.handle.net/2429/353
Chicago Manual of Style (16th Edition):
de Jong, Susan Rachel Dean. “Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides.” 2007. Doctoral Dissertation, University of British Columbia. Accessed January 16, 2021.
http://hdl.handle.net/2429/353.
MLA Handbook (7th Edition):
de Jong, Susan Rachel Dean. “Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides.” 2007. Web. 16 Jan 2021.
Vancouver:
de Jong SRD. Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides. [Internet] [Doctoral dissertation]. University of British Columbia; 2007. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/2429/353.
Council of Science Editors:
de Jong SRD. Immunostimulatory properties and mechanisms of action of encapsulated methylated cpg oligodeoxynucleotides. [Doctoral Dissertation]. University of British Columbia; 2007. Available from: http://hdl.handle.net/2429/353
University of Kansas
17.
Brachtenbach, Allison Jo.
Characterization of MSY Nanodiamonds as a Nanoparticulate Adjuvant for RiVax Vaccine.
Degree: MS, Bioengineering, 2019, University of Kansas
URL: http://hdl.handle.net/1808/30490
► Vaccines are weakened or mutated versions of the pathogens that invoke an immune response through controlled and targeted delivery. Live-attenuated and inactivated vaccines invoke an…
(more)
▼ Vaccines are weakened or mutated versions of the pathogens that invoke an immune response through controlled and targeted delivery. Live-attenuated and inactivated vaccines invoke an immediate and protective immune response but have higher risks in a subset of patients. Subunit vaccines are an antigenic part of the pathogen that can be paired with an adjuvant to invoke an effective immune response and cause less adverse reactions.
Adjuvants are made of a wide variety of materials that aid in antigenic expression in the body, in hopes of providing protection. Nanodiamonds have a 3D carbon structure that has highly tailorable surface chemistry to provide customization for interaction of antigens that would mimic an effect similar to a virus-like particle. Here, the synthesis of modified nanodiamonds is further developed by chemical modifications into three derivatives: oxidized, acidified, and amine modified nanodiamonds. Each derivative was compositionally and morphologically characterized to understand their stability and binding capacity. The unmodified nanodiamonds were selected to be further characterized but with a vaccine called RiVax. RiVax is a mutated ricin protein that prevents ricin toxicity for up to four months, but greater longevity and immunity is desired. In in vivo release studies, RiVax adsorbed to the unmodified nanodiamonds had recognition of adsorbed ricin and significantly low recognition of soluble ricin, leading to a survival rate of 50% in mice. Overall, nanodiamonds did not improve the RiVax vaccine but has shown respectable alterability, which could be beneficial to other subunit vaccines.
Advisors/Committee Members: Forrest, Laird (advisor), Middaugh, Russ (cmtemember), Dekosky, Brandon (cmtemember).
Subjects/Keywords: Bioengineering; Pharmaceutical sciences; adjuvants; carbon; Nanodiamonds; RiVax
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Brachtenbach, A. J. (2019). Characterization of MSY Nanodiamonds as a Nanoparticulate Adjuvant for RiVax Vaccine. (Masters Thesis). University of Kansas. Retrieved from http://hdl.handle.net/1808/30490
Chicago Manual of Style (16th Edition):
Brachtenbach, Allison Jo. “Characterization of MSY Nanodiamonds as a Nanoparticulate Adjuvant for RiVax Vaccine.” 2019. Masters Thesis, University of Kansas. Accessed January 16, 2021.
http://hdl.handle.net/1808/30490.
MLA Handbook (7th Edition):
Brachtenbach, Allison Jo. “Characterization of MSY Nanodiamonds as a Nanoparticulate Adjuvant for RiVax Vaccine.” 2019. Web. 16 Jan 2021.
Vancouver:
Brachtenbach AJ. Characterization of MSY Nanodiamonds as a Nanoparticulate Adjuvant for RiVax Vaccine. [Internet] [Masters thesis]. University of Kansas; 2019. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/1808/30490.
Council of Science Editors:
Brachtenbach AJ. Characterization of MSY Nanodiamonds as a Nanoparticulate Adjuvant for RiVax Vaccine. [Masters Thesis]. University of Kansas; 2019. Available from: http://hdl.handle.net/1808/30490
18.
Ji, Jie.
Targeting the innate immune system to develop novel prophylactic strategies: lessons from amphioxus (B. lanceolatum) and zebrafish (D. rerio).
Degree: Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia, 2017, Universitat Autònoma de Barcelona
URL: http://hdl.handle.net/10803/525852
► Immunization through vaccination is one of the most effective strategies to control infectious diseases. However, effective vaccines and alternative prophylactic tools for many fish diseases…
(more)
▼ Immunization through vaccination is one of the most effective strategies to control infectious diseases. However, effective vaccines and alternative prophylactic tools for many fish diseases are still lacking. More studies on basic and applied immunology are required to improve the prevention and control of diseases in aquaculture. In this context, the thesis presents both basic and applied research. The Toll-like receptors (TLRs) are important for raising innate immune defense and their ligands are used as vaccine
adjuvants to improve the immune responses. We studied the TLR system in the amphioxus B. lanceolatum. We identified 28 new putative TLR genes which consist in both non-vertebrate- and vertebrate-like TLRs. We cloned one of these genes, Bl_TLRj. The phylogenetic analysis together with functional analysis showed that it clusters with TLR11 family and particularly with subfamily 13. Moreover, Bl_TLRj responded against viral stimuli and showed high sequence identity with fish TLR13 and TLR22. Second, we developed two different infection models in zebrafish and we tested two potential nanoparticle
adjuvants, IBsTNFα and NLc. The IBsTNFα are a highly stable, non-toxic, and low-cost protein-based biomaterial formed with nano-structured trout tumor necrosis factor alpha cytokine. Via oral intubation of adult zebrafish, combining flow cytometry, histology, and confocal microscopy, we show that IBsTNFα are able to cross the intestinal mucosal epithelial barriers, pass through the lamina propria, and reach the muscle layer. The expression of innate immune-related genes was significantly up-regulated in zebrafish intestine. Finally, IBsTNFα could protect zebrafish against a Mycobacterium marinum lethal infection when i.p. injected. The second particle tested, NLc, was previously developed in our lab and is composed by nanoliposomes encapsulating LPS and Poly I:C. The NLc was tested in our M. marinum bacterial infection model and it could protect zebrafish against a lethal infection when i.p. injected. Next, we explored the infective possibilities of two fish pathogens, M. marinum and Aeromonas hydrophila, in zebrafish larvae by immersion. The mortality of zebrafish larvae immersed with M. marinum showed no significant differences but zebrafish larvae infected with A. hydrophila by immersion showed significant differences compared to controls in a dose-dependent manner. NLc and IBsTNFα localized in the pharynx and intestine of zebrafish larvae at 3 and 5 dpf, respectively. The expression of immune-related genes such as IL-1β and IRF1α was significantly up-regulated after 48 h treatment with NLc in 2 dpf larvae. The 5 dpf larvae immersion in IBsTNFα could not significantly alter immune-related gene expression and IBsTNFα could not protect zebrafish larvae against A. hydrophila lethal infection.
Advisors/Committee Members: [email protected] (authoremail), true (authoremailshow), Roher Armentia, Nerea (director), true (authorsendemail).
Subjects/Keywords: Inmunologia; Immunología; Immunology; Toll-like receptor; Adjuvants; Adyuvantes; Adjuvants; Ciències Experimentals; 57
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Ji, J. (2017). Targeting the innate immune system to develop novel prophylactic strategies: lessons from amphioxus (B. lanceolatum) and zebrafish (D. rerio). (Thesis). Universitat Autònoma de Barcelona. Retrieved from http://hdl.handle.net/10803/525852
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ji, Jie. “Targeting the innate immune system to develop novel prophylactic strategies: lessons from amphioxus (B. lanceolatum) and zebrafish (D. rerio).” 2017. Thesis, Universitat Autònoma de Barcelona. Accessed January 16, 2021.
http://hdl.handle.net/10803/525852.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ji, Jie. “Targeting the innate immune system to develop novel prophylactic strategies: lessons from amphioxus (B. lanceolatum) and zebrafish (D. rerio).” 2017. Web. 16 Jan 2021.
Vancouver:
Ji J. Targeting the innate immune system to develop novel prophylactic strategies: lessons from amphioxus (B. lanceolatum) and zebrafish (D. rerio). [Internet] [Thesis]. Universitat Autònoma de Barcelona; 2017. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/10803/525852.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ji J. Targeting the innate immune system to develop novel prophylactic strategies: lessons from amphioxus (B. lanceolatum) and zebrafish (D. rerio). [Thesis]. Universitat Autònoma de Barcelona; 2017. Available from: http://hdl.handle.net/10803/525852
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Université de Sherbrooke
19.
Lemoyne, Luc.
Étude du comportement de bétons à base de ciment mélangé aux fumées de silice.
Degree: 1988, Université de Sherbrooke
URL: http://hdl.handle.net/11143/15897
► Les fumées de silice sont un sous-produit industriel utilisées dans le béton comme ajout cimentaire. Habituellement, au Québec, on incorpore les fumées de silice avec…
(more)
▼ Les fumées de silice sont un sous-produit industriel utilisées dans le béton comme ajout cimentaire. Habituellement, au Québec, on incorpore les fumées de silice avec les autres constituants dans les usines de béton, et l'homogénéité du liant n'est pas toujours parfaite. Nous avons effectué un projet de recherche pour comparer le comportement des bétons fabriqués avec un ciment mélangé aux fumées de silice à celui d'autres bétons contenant du ciment de Type 10 ou de Type 20, jusqu'après 1 an de mûrissement. Nous avons étudié les propriétés physiques et mécaniques, la fissuration et la microstructure. Les résultats obtenus nous montrent qu'à l'état frais, les bétons contenant ce ciment mélangé se comportent très bien dans le temps. Ces derniers ont des temps de prise et une augmentation de la température d'hydratation plus précoces que les bétons de référence. Leur résistance en compression est plus élevée à court terme mais ils sont plus sensibles au phénomène de fissuration plastique. Enfin, à long terme, ils ont une résistance en compression plus élevée, une porosité plus fine, un retrait plus faible, une moins grande perméabilité, moins de fissures superficielles et une matrice plus dense contenant moins de chaux libre.
Advisors/Committee Members: Aïtcin, Pierre-Claude (advisor).
Subjects/Keywords: Béton – Adjuvants; Ciment – Adjuvants; Silice – Technique minière; Béton – Vibration
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lemoyne, L. (1988). Étude du comportement de bétons à base de ciment mélangé aux fumées de silice. (Masters Thesis). Université de Sherbrooke. Retrieved from http://hdl.handle.net/11143/15897
Chicago Manual of Style (16th Edition):
Lemoyne, Luc. “Étude du comportement de bétons à base de ciment mélangé aux fumées de silice.” 1988. Masters Thesis, Université de Sherbrooke. Accessed January 16, 2021.
http://hdl.handle.net/11143/15897.
MLA Handbook (7th Edition):
Lemoyne, Luc. “Étude du comportement de bétons à base de ciment mélangé aux fumées de silice.” 1988. Web. 16 Jan 2021.
Vancouver:
Lemoyne L. Étude du comportement de bétons à base de ciment mélangé aux fumées de silice. [Internet] [Masters thesis]. Université de Sherbrooke; 1988. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/11143/15897.
Council of Science Editors:
Lemoyne L. Étude du comportement de bétons à base de ciment mélangé aux fumées de silice. [Masters Thesis]. Université de Sherbrooke; 1988. Available from: http://hdl.handle.net/11143/15897
Technical University of Lisbon
20.
Peres, Maria de Fátima Pratas.
Influence of enzymes and technology on the composition of Cobrançosa and Galega vulgar virgin olive oils.
Degree: 2015, Technical University of Lisbon
URL: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/12050
Subjects/Keywords: adjuvants; phenols; odourants; oxidoreductases; ripening
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Peres, M. d. F. P. (2015). Influence of enzymes and technology on the composition of Cobrançosa and Galega vulgar virgin olive oils. (Thesis). Technical University of Lisbon. Retrieved from http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/12050
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Peres, Maria de Fátima Pratas. “Influence of enzymes and technology on the composition of Cobrançosa and Galega vulgar virgin olive oils.” 2015. Thesis, Technical University of Lisbon. Accessed January 16, 2021.
http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/12050.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Peres, Maria de Fátima Pratas. “Influence of enzymes and technology on the composition of Cobrançosa and Galega vulgar virgin olive oils.” 2015. Web. 16 Jan 2021.
Vancouver:
Peres MdFP. Influence of enzymes and technology on the composition of Cobrançosa and Galega vulgar virgin olive oils. [Internet] [Thesis]. Technical University of Lisbon; 2015. [cited 2021 Jan 16].
Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/12050.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Peres MdFP. Influence of enzymes and technology on the composition of Cobrançosa and Galega vulgar virgin olive oils. [Thesis]. Technical University of Lisbon; 2015. Available from: http://www.rcaap.pt/detail.jsp?id=oai:www.repository.utl.pt:10400.5/12050
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Mississippi State University
21.
Sperry, Benjamin P.
Optimizing residual herbicides in mid-south cropping systems.
Degree: PhD, Mississippi State University, 2019, Mississippi State University
URL: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03182019-180352/
;
► Adoption of conservation tillage and the use of cover crops for benefits associated with soil health and weed control has increased in recent years. In…
(more)
▼ Adoption of conservation tillage and the use of cover crops for benefits associated with soil health and weed control has increased in recent years. In these systems, the reliance on postemergent (POST) herbicides such as glyphosate has resulted in widespread resistance in weeds. Consequently, residual herbicides must also be used in conjunction with conservation tillage practices and POST herbicides to reduce risk of further resistance evolution. However, residual herbicide applications to crop residue covered soil commonly results in herbicide losses of up to 50% due to interception and adsorption to organic matter (OM). Therefore, greenhouse and field experiments were conducted in 2017 and 2018 in effort to identify application methods and other practices that result in greater efficacy when residual herbicides are applied to crop residue. In the field, efficacy of residual herbicides after application to crop residue-covered soils was enhanced with increasing carrier volumes and most herbicides performed better with XR nozzles compared to TTI nozzles. However, minimum carrier volumes and nozzles required for successful weed control were largely product-specific. In a greenhouse experiment, the addition of a silicone-based adjuvant at an optimal concentration improved acetochlor efficacy after application to wheat straw. Likewise, acetochlor efficacy from application to wheat straw was increased with greater volumes of simulated rainfall. In addition to conservation tillage related experiments, field experiments were conducted in 2017 and 2018 in Mississippi and Nebraska to quantify the relative duration of weed control provided by many commonly used residual herbicides in effort to identify when weed control starts to decline relative to initial application. Lastly, a field experiment was conducted investigating the effects of carrier volume and spray quality in simulated dicamba drift on susceptible soybean experiments. Carrier volume was found to profoundly affect soybean response to dicamba and should be considered in future simulated drift studies.
Advisors/Committee Members: Dr. Ashli B. Johnson (committee member), Dr. Greg R. Kruger (committee member), Dr. Daniel B. Reynolds (chair), Dr. J. Connor Ferguson (committee member), Dr. Jason A. Bond (committee member).
Subjects/Keywords: cover crop; adsorption; residual weed control; adjuvants; off-target movement
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sperry, B. P. (2019). Optimizing residual herbicides in mid-south cropping systems. (Doctoral Dissertation). Mississippi State University. Retrieved from http://sun.library.msstate.edu/ETD-db/theses/available/etd-03182019-180352/ ;
Chicago Manual of Style (16th Edition):
Sperry, Benjamin P. “Optimizing residual herbicides in mid-south cropping systems.” 2019. Doctoral Dissertation, Mississippi State University. Accessed January 16, 2021.
http://sun.library.msstate.edu/ETD-db/theses/available/etd-03182019-180352/ ;.
MLA Handbook (7th Edition):
Sperry, Benjamin P. “Optimizing residual herbicides in mid-south cropping systems.” 2019. Web. 16 Jan 2021.
Vancouver:
Sperry BP. Optimizing residual herbicides in mid-south cropping systems. [Internet] [Doctoral dissertation]. Mississippi State University; 2019. [cited 2021 Jan 16].
Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03182019-180352/ ;.
Council of Science Editors:
Sperry BP. Optimizing residual herbicides in mid-south cropping systems. [Doctoral Dissertation]. Mississippi State University; 2019. Available from: http://sun.library.msstate.edu/ETD-db/theses/available/etd-03182019-180352/ ;
22.
Nassar, Rafael Salim.
Potencial da migalina (Acilpoliamina) como agente imunomodulador das funções de macrófagos murinos.
Degree: Mestrado, Biotecnologia, 2013, University of São Paulo
URL: http://www.teses.usp.br/teses/disponiveis/87/87131/tde-06112013-100747/
;
► As poliaminas são essenciais para o controle dos mecanismos celulares nos seres vivos. A Migalina é uma acilpoliamina isolada de A. gomesiana com atividade microbicida…
(more)
▼ As poliaminas são essenciais para o controle dos mecanismos celulares nos seres vivos. A Migalina é uma acilpoliamina isolada de A. gomesiana com atividade microbicida contra E. coli, contudo, seu efeito imunomodulador é desconhecido. Sabendo que os mediadores imunes produzidos por macrófagos são críticos para a regulação da resposta imune, investigamos o efeito in vitro da Migalina sobre estas células. Demonstramos que a Migalina não induziu citotoxicidade, mas ativou iNOS, potencializando a síntese de nitrito. Aumentou a produção de TNF-a, mas não de IL-12p40. IL-1b não foi detectada. Além disto, Inibiu a produção de TNF-a e IL-12p40 induzida por LPS e quando associada à Polimixina B não alterou a síntese de TNF-a. Macrófagos deficientes de MyD88 não produziram TNF-a em resposta a Migalina, sugerindo que a sinalização mediada por TLR via MyD88 é requerida para a produção desta citocina. Comprovamos que a Migalina modula a atividade de macrófagos através de mediadores da resposta imune inata e pode ser explorada como estratégia no controle de infecções.
Polyamines are present in most living organisms. Mygalin is an acylpolyamine isolated from A. gomesiana that showed microbicide activity against E. coli, however, its immunomodulator effect has not been explored. Immune mediators produced by macrophages are essential for the regulation of immune responses. Our results showed that murine macrophages stimulated in vitro with Mygalin didnt induce cytotoxicity, but activated iNOS, inducing nitrite synthesis. The production of TNF-a was enhanced, but IL-12p40 was not. The presence of IL-1b was not detected. In higher concentrations, Mygalin inhibited significantly the production of IL-12p40 and TNF-a induced by LPS, and its association with Polymixine B did not altered the production profile of TNF-a. Macrophages deficient in MyD88 molecule activated with Mygalin did not induce the synthesis of TNF-a. Our results showed that Mygalin is capable of modulating the macrophage activity by inducing mediators of innate immune response and can be explored as a strategy in the studies to control pathogen infections.
Advisors/Committee Members: Borges, Monamaris Marques.
Subjects/Keywords: Adjuvantes imunológicos; Camundongos; Citocinas; Cytokines; Fagocitose; Immune adjuvants; Mice; Phagocytosis
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nassar, R. S. (2013). Potencial da migalina (Acilpoliamina) como agente imunomodulador das funções de macrófagos murinos. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/87/87131/tde-06112013-100747/ ;
Chicago Manual of Style (16th Edition):
Nassar, Rafael Salim. “Potencial da migalina (Acilpoliamina) como agente imunomodulador das funções de macrófagos murinos.” 2013. Masters Thesis, University of São Paulo. Accessed January 16, 2021.
http://www.teses.usp.br/teses/disponiveis/87/87131/tde-06112013-100747/ ;.
MLA Handbook (7th Edition):
Nassar, Rafael Salim. “Potencial da migalina (Acilpoliamina) como agente imunomodulador das funções de macrófagos murinos.” 2013. Web. 16 Jan 2021.
Vancouver:
Nassar RS. Potencial da migalina (Acilpoliamina) como agente imunomodulador das funções de macrófagos murinos. [Internet] [Masters thesis]. University of São Paulo; 2013. [cited 2021 Jan 16].
Available from: http://www.teses.usp.br/teses/disponiveis/87/87131/tde-06112013-100747/ ;.
Council of Science Editors:
Nassar RS. Potencial da migalina (Acilpoliamina) como agente imunomodulador das funções de macrófagos murinos. [Masters Thesis]. University of São Paulo; 2013. Available from: http://www.teses.usp.br/teses/disponiveis/87/87131/tde-06112013-100747/ ;
23.
Singh, Parvinder Pal.
Design and synthesis of novel immune adjuvants for
vaccines and development of small molecule
immunomodulators.
Degree: Chemistry, 2013, Guru Nanak Dev University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/10332
None
Summary p.223-233, References included in chapters,
Others p. 224
Advisors/Committee Members: Sampath Kumar H M.Subjects/Keywords: Vaccines; Adjuvants; Molecule immunomodulators
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Singh, P. P. (2013). Design and synthesis of novel immune adjuvants for
vaccines and development of small molecule
immunomodulators. (Thesis). Guru Nanak Dev University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/10332
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Singh, Parvinder Pal. “Design and synthesis of novel immune adjuvants for
vaccines and development of small molecule
immunomodulators.” 2013. Thesis, Guru Nanak Dev University. Accessed January 16, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/10332.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Singh, Parvinder Pal. “Design and synthesis of novel immune adjuvants for
vaccines and development of small molecule
immunomodulators.” 2013. Web. 16 Jan 2021.
Vancouver:
Singh PP. Design and synthesis of novel immune adjuvants for
vaccines and development of small molecule
immunomodulators. [Internet] [Thesis]. Guru Nanak Dev University; 2013. [cited 2021 Jan 16].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10332.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Singh PP. Design and synthesis of novel immune adjuvants for
vaccines and development of small molecule
immunomodulators. [Thesis]. Guru Nanak Dev University; 2013. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/10332
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
24.
Sidiq,Tabasum.
Development of Vaccine Adjuvants from Asparagus racemosus
and Lipidated Tripeptides in response to HBsAg; No.
Degree: Science, 2014, Guru Nanak Dev University
URL: http://shodhganga.inflibnet.ac.in/handle/10603/29736
Available newline
Summary: 153-157, Reference:158-199, Annexure and
Publication on the last pages
Advisors/Committee Members: Johri,R. K..Subjects/Keywords: Vaccine Adjuvants; Lipidated Tripeptides
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Sidiq,Tabasum. (2014). Development of Vaccine Adjuvants from Asparagus racemosus
and Lipidated Tripeptides in response to HBsAg; No. (Thesis). Guru Nanak Dev University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/29736
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sidiq,Tabasum. “Development of Vaccine Adjuvants from Asparagus racemosus
and Lipidated Tripeptides in response to HBsAg; No.” 2014. Thesis, Guru Nanak Dev University. Accessed January 16, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/29736.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sidiq,Tabasum. “Development of Vaccine Adjuvants from Asparagus racemosus
and Lipidated Tripeptides in response to HBsAg; No.” 2014. Web. 16 Jan 2021.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Vancouver:
Sidiq,Tabasum. Development of Vaccine Adjuvants from Asparagus racemosus
and Lipidated Tripeptides in response to HBsAg; No. [Internet] [Thesis]. Guru Nanak Dev University; 2014. [cited 2021 Jan 16].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/29736.
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sidiq,Tabasum. Development of Vaccine Adjuvants from Asparagus racemosus
and Lipidated Tripeptides in response to HBsAg; No. [Thesis]. Guru Nanak Dev University; 2014. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/29736
Note: this citation may be lacking information needed for this citation format:
Author name may be incomplete
Not specified: Masters Thesis or Doctoral Dissertation
25.
Choubey, Meenakshi.
Novel adjuvants based hepatitis b vaccine development and
characterization; -.
Degree: Microbiology, 2002, INFLIBNET
URL: http://shodhganga.inflibnet.ac.in/handle/10603/34075
Subjects/Keywords: characterization; development; hepatitis; Novel adjuvants
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Choubey, M. (2002). Novel adjuvants based hepatitis b vaccine development and
characterization; -. (Thesis). INFLIBNET. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/34075
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Choubey, Meenakshi. “Novel adjuvants based hepatitis b vaccine development and
characterization; -.” 2002. Thesis, INFLIBNET. Accessed January 16, 2021.
http://shodhganga.inflibnet.ac.in/handle/10603/34075.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Choubey, Meenakshi. “Novel adjuvants based hepatitis b vaccine development and
characterization; -.” 2002. Web. 16 Jan 2021.
Vancouver:
Choubey M. Novel adjuvants based hepatitis b vaccine development and
characterization; -. [Internet] [Thesis]. INFLIBNET; 2002. [cited 2021 Jan 16].
Available from: http://shodhganga.inflibnet.ac.in/handle/10603/34075.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Choubey M. Novel adjuvants based hepatitis b vaccine development and
characterization; -. [Thesis]. INFLIBNET; 2002. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/34075
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Universidade Federal de Santa Maria
26.
Gislene de Andrade Nicolodi.
CONTROLE DE IPOMOEA TRILOBA COM GLIFOSATO ASSOCIADO A ADITIVOS E ADJUVANTES DE CALDA.
Degree: 2009, Universidade Federal de Santa Maria
URL: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2837
► O herbicida glifosato é usualmente utilizado no controle de plantas daninhas na cultura da soja, existindo algumas espécies tolerantes a ele. A espécie daninha Ipomoea…
(more)
▼ O herbicida glifosato é usualmente utilizado no controle de plantas daninhas na cultura da soja, existindo algumas espécies tolerantes a ele. A espécie daninha Ipomoea triloba (corriola) é tolerante às doses usuais do herbicida glifosato, portanto há a necessidade de aumentar a sua dose para o controle eficaz. Tem-se também, utilizado adjuvantes e aditivos de calda para melhorar o desempenho de controle com este herbicida. Em vista disto, foram então realizados quatro experimentos, três em campo, e um em casa de vegetação. Os três primeiros tinham como objetivo avaliar o controle de I. triloba com formulações de glifosato associado a aditivos e adjuvantes de calda, onde o Experimento I foi programado para a aplicação em condições de baixa umidade relativa do ar (UR) (abaixo de 40%) e os Experimentos II e III para UR ideal (acima de 60%). O quarto experimento visava avaliar o controle de I. triloba com diferentes doses de glifosato Trop associada a diferentes adjuvantes e aditivos de calda. Os resultados mostraram que a adição do herbicida glifosato e de adjuvantes reduz o pH da calda. O herbicida utilizado nos tratamentos I e II deve ser aplicado em doses maiores para que ocorra controle eficiente da espécie. Não ocorreu melhora na eficiência de controle com a adição de adjuvantes ao herbicida, na dose recomendada do produto. A aplicação de adjuvantes associado ao glifosato utilizado não melhorou a eficiência de controle no experimento III, na menor dose usada. E para o experimento de curva de dose-resposta concluiu-se que somente a adição dos aditivos uréia e A-20 ao glifosato demonstraram resultados no controle. Quanto à massa de matéria seca, a adição dos adjuvantes e aditivos, com exceção do Impact Plus, proporcionou uma melhora no desempenho de controle do glifosato sobre I. triloba.
The herbicide glyphosate is commonly used to control weeds in the soybean crop, with some species tolerant to it. The weed species Ipomoea triloba (bindweed) is tolerant to the usual doses of the herbicide glyphosate, so there is a need to increase your dose to control effectively. It is also used to spray adjuvants and additives to improve the performance of control with this herbicide. In view of this, four experiments were conducted, three in the field, and one in the greenhouse. The first three were to evaluate the control of I. triloba with formulations of glyphosate associated with the additives and processing of water, where the Experiment I was set to low relative humidity (RH) (below 40%) and Experiments II and III to RH ideal (above 60%). The fourth experiment aimed to evaluate the control of I. triloba with different doses of glyphosate Trop associated with different adjuvants and additives for water. The results showed that the addition of the herbicide glyphosate and adjuvants reduces the pH of the solution. The herbicide used in treatments I and II should be applied in higher doses to have efficient control of the species. There was improvement in the efficiency of control with the addition of adjuvants to the…
Advisors/Committee Members: Luis Antonio de Avila, Nelson Diehl Kruse, Cláudia das Neves Costa.
Subjects/Keywords: glifosato; Ipomoea triloba; adjuvantes; AGRONOMIA; adjuvants; Ipomoea triloba; glyphosate
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Nicolodi, G. d. A. (2009). CONTROLE DE IPOMOEA TRILOBA COM GLIFOSATO ASSOCIADO A ADITIVOS E ADJUVANTES DE CALDA. (Thesis). Universidade Federal de Santa Maria. Retrieved from http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2837
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nicolodi, Gislene de Andrade. “CONTROLE DE IPOMOEA TRILOBA COM GLIFOSATO ASSOCIADO A ADITIVOS E ADJUVANTES DE CALDA.” 2009. Thesis, Universidade Federal de Santa Maria. Accessed January 16, 2021.
http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2837.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nicolodi, Gislene de Andrade. “CONTROLE DE IPOMOEA TRILOBA COM GLIFOSATO ASSOCIADO A ADITIVOS E ADJUVANTES DE CALDA.” 2009. Web. 16 Jan 2021.
Vancouver:
Nicolodi GdA. CONTROLE DE IPOMOEA TRILOBA COM GLIFOSATO ASSOCIADO A ADITIVOS E ADJUVANTES DE CALDA. [Internet] [Thesis]. Universidade Federal de Santa Maria; 2009. [cited 2021 Jan 16].
Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2837.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nicolodi GdA. CONTROLE DE IPOMOEA TRILOBA COM GLIFOSATO ASSOCIADO A ADITIVOS E ADJUVANTES DE CALDA. [Thesis]. Universidade Federal de Santa Maria; 2009. Available from: http://coralx.ufsm.br/tede/tde_busca/arquivo.php?codArquivo=2837
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Université du Québec à Montréal
27.
Mireault, Caroline.
Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?.
Degree: 2018, Université du Québec à Montréal
URL: http://archipel.uqam.ca/11223/1/M15557.pdf
► Les faux documents d'identité représentent un problème important de sécurité. Ces pièces sont couramment utilisées pour faciliter la commission de nombreux crimes, allant du trafic…
(more)
▼ Les faux documents d'identité représentent un problème important de sécurité. Ces pièces sont couramment utilisées pour faciliter la commission de nombreux crimes, allant du trafic de stupéfiants au terrorisme. En ce sens, le développement de méthodes (comme le profilage visuel des faux documents) pour mieux comprendre la criminalité derrière ce phénomène peut permettre de générer des informations utiles aux enquêtes. Ce projet de recherche vise à développer une méthode de profilage chimique de faux documents d'identité, complémentaire au profilage optique, et d'évaluer son potentiel en renseignement criminalistique. La stratégie envisagée est d'analyser les additifs contenus dans les supports polymériques des documents d'identité étudiés afin d'obtenir un profil chimique propre à chacun. Dans cette optique, un protocole exploratoire complet d'analyse chimique en quatre étapes a été développé : identification des classes de polymères constituant le document par spectroscopie infrarouge; extraction des additifs du substrat polymérique; analyse des extraits par chromatographie en phase liquide et spectrométrie de masse et, finalement, sélection des composés cibles pour générer les profils. La méthodologie a été appliquée à des permis de conduire québécois authentiques et des permis nigérians et bangladais, contrefaits et authentiques. Les résultats ont démontré une bonne reproductibilité dans la nature des composés extraits. Cependant, une plus grande variation a été observée pour la stabilité du système analytique quant aux aires des pics des composés détectés, invitant ainsi à des analyses semi-quantitatives ou qualitatives. Certaines incertitudes et limitations ont été soulevées quant à la méthodologie employée permettant ainsi de suggérer de nouvelles pistes de recherche intéressantes. L'utilisation d'outils chimiométriques a permis de comparer les profils chimiques obtenus pour chaque document. Des liens entre les spécimens de chaque jeu de données ont pu être détectés. Malgré le manque de données circonstancielles concernant les saisies des spécimens étudiés, plusieurs hypothèses ont pu être émises quant à l'utilisation du matériel propre à la production des fausses cartes d'identité. Déjà, ce travail exploratoire permet de discuter du potentiel du profilage chimique à fournir du renseignement forensique complémentaire au profilage visuel déjà existant, notamment par la possibilité de détecter des liens entre faux documents de différentes natures.
____________________________________________________________________________
MOTS-CLÉS DE L’AUTEUR : Science forensique, criminalistique, fausses pièces d'identité, faux documents d'identité, renseignement forensique, polymères, additifs, profilage, chimie analytique.
Subjects/Keywords: Cartes d'identité – Faux – Identification; Polymères – Adjuvants – Analyse; Chimie analytique; Criminalistique
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mireault, C. (2018). Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?. (Thesis). Université du Québec à Montréal. Retrieved from http://archipel.uqam.ca/11223/1/M15557.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mireault, Caroline. “Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?.” 2018. Thesis, Université du Québec à Montréal. Accessed January 16, 2021.
http://archipel.uqam.ca/11223/1/M15557.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mireault, Caroline. “Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?.” 2018. Web. 16 Jan 2021.
Vancouver:
Mireault C. Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?. [Internet] [Thesis]. Université du Québec à Montréal; 2018. [cited 2021 Jan 16].
Available from: http://archipel.uqam.ca/11223/1/M15557.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mireault C. Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?. [Thesis]. Université du Québec à Montréal; 2018. Available from: http://archipel.uqam.ca/11223/1/M15557.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Université Laval
28.
Tremblay, Sofie.
Étude de l'efficacité d'adjuvants à base de lithium afin
de contrôler la réaction alcalis-silice dans le béton frais et dans
les structures existantes incorporant cet adjuvant.
Degree: 2011, Université Laval
URL: http://hdl.handle.net/20.500.11794/22919
► La réaction alcalis-silice (RAS) est une des causes principales de détérioration précoce des bétons utilisés dans la fabrication des infrastructures. La RAS, qualifiée de cancer…
(more)
▼ La réaction alcalis-silice (RAS) est une des causes
principales de détérioration précoce des bétons utilisés dans la
fabrication des infrastructures. La RAS, qualifiée de cancer du
béton, est une réaction se produisant entre les hydroxydes alcalins
de la solution présente dans les pores de la pâte de ciment
hydratée et certaines phases minérales siliceuses des granulats.
Cette réaction engendre la formation d'un gel expansif qui absorbe
des molécules d'eau et diverses espèces ioniques de la solution
interstitielle, créant ainsi une pression entraînant la
microfissuration interne du béton, la macrofissuration de surface
et ultimement, dans certains cas, une réduction significative de la
durée de vie utile de l’élément atteint. Ce type de réaction touche
un grand nombre de structures au Québec, au Canada et à travers le
monde; un des principaux problèmes lié à ce phénomène est qu’il est
très difficile de réparer de façon efficace les structures
affectées par ce " cancer ". Les essais normalisés A23.2-27A et 28A
de l'Association Canadienne de Normalisation (CSA) (2009); (CSA)
(2009) proposent diverses mesures préventives afin d'éviter que ne
se développe la RAS dans les nouvelles structures de béton. Ces
mesures incluent l'utilisation d'ajouts cimentaires ou
l’utilisation d’adjuvant chimique à base de lithium. C’est en fait
dès le début des années 50 que deux chercheurs ont démontrés que
l'utilisation d’
adjuvants chimiques à base de nitrate de lithium
(LiNO3) tendait à diminuer efficacement l’expansion associée à
cette réaction chimique nuisible (McCoy et Caldwell (1951)). Les
mécanismes proposés permettant d’expliquer l’efficacité du lithium
afin de contrer la RAS sont multiples. Selon Tremblay et al.
(2010), certains ont été investigués davantage et certains sont
plus probables que d’autres. Ce mémoire portera sur la présentation
des différents indices pétrographiques de détérioration permettant
d’expliquer l’efficacité du LiNO3 afin de contrer la RAS. Pour ce
faire, des essais de laboratoire effectués sur des éprouvettes de
béton ainsi que des barres de mortier contenant diverses
concentrations en LiNO3 seront présentés. Les indices de
détérioration obtenus, un mécanisme pourra être
élaboré.
Advisors/Committee Members: Duchesne, Josée, Fournier, Benoît.
Subjects/Keywords: QE 3.5 UL 2011; Réactions alcalis-granulats; Béton – Adjuvants; Béton – Détérioration
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Tremblay, S. (2011). Étude de l'efficacité d'adjuvants à base de lithium afin
de contrôler la réaction alcalis-silice dans le béton frais et dans
les structures existantes incorporant cet adjuvant. (Thesis). Université Laval. Retrieved from http://hdl.handle.net/20.500.11794/22919
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Tremblay, Sofie. “Étude de l'efficacité d'adjuvants à base de lithium afin
de contrôler la réaction alcalis-silice dans le béton frais et dans
les structures existantes incorporant cet adjuvant.” 2011. Thesis, Université Laval. Accessed January 16, 2021.
http://hdl.handle.net/20.500.11794/22919.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Tremblay, Sofie. “Étude de l'efficacité d'adjuvants à base de lithium afin
de contrôler la réaction alcalis-silice dans le béton frais et dans
les structures existantes incorporant cet adjuvant.” 2011. Web. 16 Jan 2021.
Vancouver:
Tremblay S. Étude de l'efficacité d'adjuvants à base de lithium afin
de contrôler la réaction alcalis-silice dans le béton frais et dans
les structures existantes incorporant cet adjuvant. [Internet] [Thesis]. Université Laval; 2011. [cited 2021 Jan 16].
Available from: http://hdl.handle.net/20.500.11794/22919.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Tremblay S. Étude de l'efficacité d'adjuvants à base de lithium afin
de contrôler la réaction alcalis-silice dans le béton frais et dans
les structures existantes incorporant cet adjuvant. [Thesis]. Université Laval; 2011. Available from: http://hdl.handle.net/20.500.11794/22919
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Université du Québec à Montréal
29.
Mireault, Caroline.
Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?.
Degree: 2018, Université du Québec à Montréal
URL: http://archipel.uqam.ca/11223/1/M15557.pdf
► Les faux documents d'identité représentent un problème important de sécurité. Ces pièces sont couramment utilisées pour faciliter la commission de nombreux crimes, allant du trafic…
(more)
▼ Les faux documents d'identité représentent un problème important de sécurité. Ces pièces sont couramment utilisées pour faciliter la commission de nombreux crimes, allant du trafic de stupéfiants au terrorisme. En ce sens, le développement de méthodes (comme le profilage visuel des faux documents) pour mieux comprendre la criminalité derrière ce phénomène peut permettre de générer des informations utiles aux enquêtes. Ce projet de recherche vise à développer une méthode de profilage chimique de faux documents d'identité, complémentaire au profilage optique, et d'évaluer son potentiel en renseignement criminalistique. La stratégie envisagée est d'analyser les additifs contenus dans les supports polymériques des documents d'identité étudiés afin d'obtenir un profil chimique propre à chacun. Dans cette optique, un protocole exploratoire complet d'analyse chimique en quatre étapes a été développé : identification des classes de polymères constituant le document par spectroscopie infrarouge; extraction des additifs du substrat polymérique; analyse des extraits par chromatographie en phase liquide et spectrométrie de masse et, finalement, sélection des composés cibles pour générer les profils. La méthodologie a été appliquée à des permis de conduire québécois authentiques et des permis nigérians et bangladais, contrefaits et authentiques. Les résultats ont démontré une bonne reproductibilité dans la nature des composés extraits. Cependant, une plus grande variation a été observée pour la stabilité du système analytique quant aux aires des pics des composés détectés, invitant ainsi à des analyses semi-quantitatives ou qualitatives. Certaines incertitudes et limitations ont été soulevées quant à la méthodologie employée permettant ainsi de suggérer de nouvelles pistes de recherche intéressantes. L'utilisation d'outils chimiométriques a permis de comparer les profils chimiques obtenus pour chaque document. Des liens entre les spécimens de chaque jeu de données ont pu être détectés. Malgré le manque de données circonstancielles concernant les saisies des spécimens étudiés, plusieurs hypothèses ont pu être émises quant à l'utilisation du matériel propre à la production des fausses cartes d'identité. Déjà, ce travail exploratoire permet de discuter du potentiel du profilage chimique à fournir du renseignement forensique complémentaire au profilage visuel déjà existant, notamment par la possibilité de détecter des liens entre faux documents de différentes natures.
____________________________________________________________________________
MOTS-CLÉS DE L’AUTEUR : Science forensique, criminalistique, fausses pièces d'identité, faux documents d'identité, renseignement forensique, polymères, additifs, profilage, chimie analytique.
Subjects/Keywords: Cartes d'identité – Faux – Identification; Polymères – Adjuvants – Analyse; Chimie analytique; Criminalistique
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Mireault, C. (2018). Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?. (Thesis). Université du Québec à Montréal. Retrieved from http://archipel.uqam.ca/11223/1/M15557.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Mireault, Caroline. “Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?.” 2018. Thesis, Université du Québec à Montréal. Accessed January 16, 2021.
http://archipel.uqam.ca/11223/1/M15557.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Mireault, Caroline. “Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?.” 2018. Web. 16 Jan 2021.
Vancouver:
Mireault C. Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?. [Internet] [Thesis]. Université du Québec à Montréal; 2018. [cited 2021 Jan 16].
Available from: http://archipel.uqam.ca/11223/1/M15557.pdf.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Mireault C. Le profilage chimique des faux documents d'identité : pertinence d'une intégration au profilage criminalistique?. [Thesis]. Université du Québec à Montréal; 2018. Available from: http://archipel.uqam.ca/11223/1/M15557.pdf
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Guelph
30.
Singh, Shirene Melissa.
Enhancement of Avian Influenza Virus vaccines in chickens through identification and application of novel mucosal adjuvants.
Degree: PhD, Department of Pathobiology, 2016, University of Guelph
URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9698
► The avian influenza virus (AIV) is a mucosal pathogen that is of relevance to the poultry industry and humans from economic and public health perspectives.…
(more)
▼ The avian influenza virus (AIV) is a mucosal pathogen that is of relevance to the poultry industry and humans from economic and public health perspectives. Most commercially available AIV vaccines are of the inactivated type requiring parenteral co-administration with a water-in-oil adjuvant to generate an antigen-specific immune response. Limitations exist in the quantity and quality of antibody-mediated immune responses generated with this approach. This research was aimed at identifying novel, more efficacious
adjuvants with the potential to be administered by the intramuscular and aerosol routes. To evaluate the adjuvant potential of class B oligodeoxynucleotides (ODNs) in chickens, 2 doses of CpG ODN (oligodeoxynucleotides containing unmethylated CpG motifs) 2007 (CpG 2007) and 1826 were administered intramuscularly (IM) with a formalin-inactivated, whole, H9N2 avian influenza virus. We concluded that different members of class B ODNs displayed various levels of adjuvancy when combined with inactivated AIV in chickens based on neutralizing and virus-specific antibody responses generated by the 2 doses. Therefore, CpG 2007 was selected at a specific dose for poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticle encapsulation which was administered with inactivated AIV through the IM and aerosol routes; systemic and local mucosal antibody-mediated responses were assessed. Significantly higher systemic and local mucosal antibody responses were observed after the administration of 3 doses of the nanoparticle-encapsulated CpG 2007 vaccine by the aerosol route compared to the formulation containing nonencapsulated CpG 2007. In contrast, significantly higher systemic and local mucosal antibody responses were induced with the nonencapsulated CpG 2007 formulation by IM administration. To gain a better understanding of the antibody-mediated immune responses, the inactivated AIV vaccine component was encapsulated for IM administration. The protective efficacy of the vaccine and the ability to generate IgY antibodies of high avidity were assessed. Nonencapsulated AIV with encapsulated CpG 2007 elicited significantly higher magnitude antibody mediated responses and a reduction in shedding of cloacal virus compared to the encapsulated AIV and encapsulated CpG formulation. High avidity IgY antibodies were induced by both formulations. In conclusion, the adjuvant potential of CpG 2007 and PLGA nanoparticles was demonstrated in the context of inactivated AIV using IM and aerosol routes of administration.
Advisors/Committee Members: Sharif, Shayan (advisor).
Subjects/Keywords: Mucosal adjuvants; Vaccines; Avian influenza virus; Chickens; CpG ODNs
Record Details
Similar Records
Cite
Share »
Record Details
Similar Records
Cite
« Share
❌
APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Singh, S. M. (2016). Enhancement of Avian Influenza Virus vaccines in chickens through identification and application of novel mucosal adjuvants. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9698
Chicago Manual of Style (16th Edition):
Singh, Shirene Melissa. “Enhancement of Avian Influenza Virus vaccines in chickens through identification and application of novel mucosal adjuvants.” 2016. Doctoral Dissertation, University of Guelph. Accessed January 16, 2021.
https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9698.
MLA Handbook (7th Edition):
Singh, Shirene Melissa. “Enhancement of Avian Influenza Virus vaccines in chickens through identification and application of novel mucosal adjuvants.” 2016. Web. 16 Jan 2021.
Vancouver:
Singh SM. Enhancement of Avian Influenza Virus vaccines in chickens through identification and application of novel mucosal adjuvants. [Internet] [Doctoral dissertation]. University of Guelph; 2016. [cited 2021 Jan 16].
Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9698.
Council of Science Editors:
Singh SM. Enhancement of Avian Influenza Virus vaccines in chickens through identification and application of novel mucosal adjuvants. [Doctoral Dissertation]. University of Guelph; 2016. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/9698
◁ [1] [2] [3] [4] [5] [6] [7] ▶
. 
Open Access Theses and Dissertations
