subject:(Adiponectin)

University of Manitoba

1. Murali, Megha. Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin.

Degree: Biochemistry and Medical Genetics, 2016, University of Manitoba

URL: http://hdl.handle.net/1993/31788

► Adiponectin is an abundant hormone secreted by adipocytes that exhibits anti-diabetic, anti-inflammatory and anti-atherogenic properties. However, in obesity, as adipocytes enlarge, adiponectin secretion declines. A… (more)

Subjects/Keywords: Adiponectin

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APA (6^th Edition):

Murali, M. (2016). Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31788

Chicago Manual of Style (16^th Edition):

Murali, Megha. “Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin.” 2016. Masters Thesis, University of Manitoba. Accessed August 21, 2019. http://hdl.handle.net/1993/31788.

MLA Handbook (7^th Edition):

Murali, Megha. “Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin.” 2016. Web. 21 Aug 2019.

Vancouver:

Murali M. Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin. [Internet] [Masters thesis]. University of Manitoba; 2016. [cited 2019 Aug 21]. Available from: http://hdl.handle.net/1993/31788.

Council of Science Editors:

Murali M. Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin. [Masters Thesis]. University of Manitoba; 2016. Available from: http://hdl.handle.net/1993/31788

2. An, Si Sandy. GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY.

Degree: 2012, Wake Forest University

URL: http://hdl.handle.net/10339/37273

► Type 2 Diabetes is a complex disease characterized by a combination of environmental, lifestyle, and genetic factors. This study seeks to explore the genetic component… (more)

Subjects/Keywords: adiponectin

…IRASFS 40 2 Linkage analysis of plasma adiponectin on chromosome 3 in IRASFS Hispanic… …families 41 3 Adiponectin levels graphed as a function of the genotype for the common variant… …and 2010 26 2. Summary of family-specific LOD score for plasma adiponectin on chromosome… …DNAs from the IRASFS families 1008 and 2010 38 4. Adiponectin analysis of HMW proportions… …44 5. Contribution of the G45R mutation to variance in serum adiponectin levels 47 6…

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APA (6^th Edition):

An, S. S. (2012). GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/37273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

An, Si Sandy. “GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY.” 2012. Thesis, Wake Forest University. Accessed August 21, 2019. http://hdl.handle.net/10339/37273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

An, Si Sandy. “GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY.” 2012. Web. 21 Aug 2019.

Vancouver:

An SS. GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY. [Internet] [Thesis]. Wake Forest University; 2012. [cited 2019 Aug 21]. Available from: http://hdl.handle.net/10339/37273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

An SS. GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY. [Thesis]. Wake Forest University; 2012. Available from: http://hdl.handle.net/10339/37273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

3. ANAHITA HAMIDI. Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore.

Degree: 2009, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/23109

Subjects/Keywords: Adiponectin; High Molecular Adiponectin; Adipsin

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APA (6^th Edition):

HAMIDI, A. (2009). Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/23109

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

HAMIDI, ANAHITA. “Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore.” 2009. Thesis, National University of Singapore. Accessed August 21, 2019. http://scholarbank.nus.edu.sg/handle/10635/23109.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

HAMIDI, ANAHITA. “Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore.” 2009. Web. 21 Aug 2019.

Vancouver:

HAMIDI A. Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore. [Internet] [Thesis]. National University of Singapore; 2009. [cited 2019 Aug 21]. Available from: http://scholarbank.nus.edu.sg/handle/10635/23109.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

HAMIDI A. Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore. [Thesis]. National University of Singapore; 2009. Available from: http://scholarbank.nus.edu.sg/handle/10635/23109

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cincinnati

4. Minter, Anne C. The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics.

Degree: MS, Allied Health Sciences: Nutrition, 2013, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012

► Adiponectin modulates a range of human physiological processes related to metabolism and inflammation. Human milk is known to contain adiponectin in a wide range of… (more)

▼ Adiponectin modulates a range of human physiological processes related to metabolism and inflammation. Human milk is known to contain adiponectin in a wide range of concentrations. Variation in adiponectin concentration remains poorly understood; thus we sought to determine its maternal anthropometric and metabolic correlates. The morning after an overnight fast, lactating mothers (N=20) provided an aliquot of milk from a complete breast expression, and underwent an oral glucose tolerance test (OGTT) and anthropometric measurement. Fasting serum (total and HMW) adiponectin and human milk adiponectin were determined by ELISA. Insulin and glucose concentrations were determined by standard clinical assays. Correlates of human milk adiponectin were evaluated using Spearman rank-order correlation coefficient (r). Adiponectin concentrations (mean [min-max] ng/mL) were: human milk, 30.7 (6.9-92.49) and serum total, 6489 (1356-20257). Human milk adiponectin and serum total adiponectin were positively correlated (r=0.45, p=0.048). Human milk adiponectin was not correlated with other full-body measures of maternal metabolic status (fasting glucose, fasting insulin, insulin sensitivity, or insulin secretion). Likewise, full-body anthropometrics (weight and BMI) were not correlated with milk adiponectin concentration. Reflective of more localized fat depots, body circumference measures became more strongly correlated with human milk adiponectin concentration with increasing proximity to the breast. Spearman correlations of circumferences with human milk adiponectin concentration were hip (r=-0.32, p=0.164); iliac crest (r=-0.46, p=0.039); waist (r=-0.50, p=0.025); under breast (r=-0.56, p=0.011). Our novel finding that under-breast circumference was the strongest correlate of human milk adiponectin suggests that the localized fat depots of the breast may be an important source of adiponectin in human milk. Further studies of how the specific fat depots of the breast and upper body independently influence the breast macro-environment and the bioactives in human milk are warranted. Advisors/Committee Members: Lee, Seung-Yeon (Committee Chair).

Subjects/Keywords: Nutrition; Hormones in human milk; Human milk adiponectin concentration; Milk adiponectin and maternal anthropometrics; Milk adiponectin and Metabolic measures; Lactation; Breastfeeding

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APA (6^th Edition):

Minter, A. C. (2013). The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012

Chicago Manual of Style (16^th Edition):

Minter, Anne C. “The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics.” 2013. Masters Thesis, University of Cincinnati. Accessed August 21, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012.

MLA Handbook (7^th Edition):

Minter, Anne C. “The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics.” 2013. Web. 21 Aug 2019.

Vancouver:

Minter AC. The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics. [Internet] [Masters thesis]. University of Cincinnati; 2013. [cited 2019 Aug 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012.

Council of Science Editors:

Minter AC. The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics. [Masters Thesis]. University of Cincinnati; 2013. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012

Linköping University

5. Simonsson, Christian. Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes.

Degree: Division of Biomedical Engineering, 2018, Linköping University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148552

► There is an ongoing worldwide obesity epidemic. As a consequence, prevalence of obesity- related diseases and conditions are rapidly increasing. One of these related… (more)

▼ There is an ongoing worldwide obesity epidemic. As a consequence, prevalence of obesity- related diseases and conditions are rapidly increasing. One of these related conditions is type 2 diabetes (T2D), which alone caused 1.5 million deaths in 2012. Thus, it is of upmost importance to develop a more complete understanding of these interrelated diseases. At the heart of all these diseases lies the adipose tissue. This tissue is a major endocrine organ, and one of the key secreted cytokines is adiponectin. Adiponectin interplays with the complex insulin signaling network, and adiponectin levels are inversely related with increased adiposity. The presence of these complex dependencies argues for the usage of mathematical modelling. In the work of Brännmark et al, a model of short-term adiponectin release has been validated. However, this model did not include adrenergic signaling, which is the canonical pathway for in situ regulation of adiponectin secretion. To fill this gap, herein, a mechanistic model describing adrenaline-induced short-term adiponectin exocytosis in white adipocytes has been constructed. The newly constructed model is capable of describing experimental data depicting adiponectin release due to adrenergic stimulation as well as data for different mediator combinations. By implementing adrenergic receptor components, the transition to a more physiological model has been initiated. By finding the smallest possible model capable of describing data, one can argue that the model depicts, to some degree, the fundamental mechanisms for short-term adiponectin secretion. Thus, this work has contributed to solidifying the framework of the mechanisms behind short-term adiponectin secretion from white adipocytes. The result of the model work upholds the role of adrenergic signaling as a central regulatory mechanism for adiponectin release. The constructed model could be used as a fundament for creating a model describing adiponectin release under diabetic conditions.

Subjects/Keywords: Systems Biology; Mathematical Modeling; Adiponectin; Adiponectin secretion; White Adipocytes; Adrenaline-induced adiponectin secretion; Medical Engineering; Medicinteknik; Medical Biotechnology; Medicinsk bioteknologi

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APA (6^th Edition):

Simonsson, C. (2018). Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes. (Thesis). Linköping University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148552

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Simonsson, Christian. “Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes.” 2018. Thesis, Linköping University. Accessed August 21, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148552.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Simonsson, Christian. “Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes.” 2018. Web. 21 Aug 2019.

Vancouver:

Simonsson C. Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes. [Internet] [Thesis]. Linköping University; 2018. [cited 2019 Aug 21]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148552.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Simonsson C. Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes. [Thesis]. Linköping University; 2018. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148552

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

6. Ritchie, Ian. Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training .

Degree: 2014, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8309

► This thesis examined whether rapid shifts in skeletal muscle redox balance that follow a high fat diet impair adiponectin (Ad) stimulated fatty acid (FA) oxidation… (more)

▼ This thesis examined whether rapid shifts in skeletal muscle redox balance that follow a high fat diet impair adiponectin (Ad) stimulated fatty acid (FA) oxidation in skeletal muscle from rats. This thesis also examined the importance of Ad as a regulator of mitochondrial content in skeletal muscle at rest and following exercise training. Lastly, this thesis examined whether Ad is required for the increased insulin response observed following exercise training A high fat diet rapidly impairs the ability of Ad to increase FA oxidation in skeletal muscle, but the underlying mechanisms are unknown. In the first study the capacity of Ad to increase palmitate oxidation in soleus and extensor digitorum longus (EDL) was attenuated with HF feeding. HF feeding decreased total GSH and GSH/2GSSG in soleus, but not EDL. N-acetylcysteine prevented the reductions in GSH and GSH/2GSSG in soleus, but did not preserve Ad response. Therefore our data indicates that Ad resistance is induced in both oxidative and glycolytic skeletal muscle, independently of altered cellular redox state. The second study examined the role of Ad as a regulator of mitochondrial content using Ad knockout (AdKO) mice. There were no differences in mitochondrial protein content in red and white gastrocnemius (RG, WG) between WT and AdKO animals. Acute exercise increased the phosphorylation of AMPK and the mRNA expression of mitochondrial proteins in RG and WG with no differences between genotypes. Finally, 8 weeks of exercise training increased the protein content of mitochondrial markers similarly in muscle from both WT and AdKO mice. We conclude that Ad is not required for the regulation of mitochondrial content at rest or during exercise training. In the third study, 8 weeks of exercise training significantly increased glucose and insulin tolerance in both WT and AdKO mice. There were no differences in glucose tolerance between genotypes but insulin tolerance was improved to a greater extent in AdKO mice. There were no genotype differences in the insulin-stimulated phosphorylation of AKT or AS160 in RG or WG. Our results indicate the presence of Ad is not required for exercise-induced increases in insulin response. Advisors/Committee Members: Dyck, David (advisor).

Subjects/Keywords: high fat diet; exercise muscle; skeletal muscle; cytokine; adipokine; adiponectin; adiponectin resistance; adiponectin deficiency; insulin sensitivity; mitochondria; fat oxidation

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APA (6^th Edition):

Ritchie, I. (2014). Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training . (Thesis). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8309

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ritchie, Ian. “Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training .” 2014. Thesis, University of Guelph. Accessed August 21, 2019. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8309.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ritchie, Ian. “Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training .” 2014. Web. 21 Aug 2019.

Vancouver:

Ritchie I. Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training . [Internet] [Thesis]. University of Guelph; 2014. [cited 2019 Aug 21]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8309.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ritchie I. Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training . [Thesis]. University of Guelph; 2014. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8309

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Utah

7. Urban, Brittney Marie. The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese.

Degree: MSin Nutrition, Nutrition, 2013, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3476/rec/2642

► Adipokines, including adiponectin and leptin, are secreted by adipose tissue. With an increase in fat mass, concentrations of adiponectin decrease and leptin increase, altering the… (more)

▼ Adipokines, including adiponectin and leptin, are secreted by adipose tissue. With an increase in fat mass, concentrations of adiponectin decrease and leptin increase, altering the adiponectin/leptin (A/L) ratio. A/L ratio is associated with metabolic dysfunction, as are multiple diet factors including breastfeeding in infancy and breakfast intake. However, it is not known whether these diet factors are related to A/L ratio, and if they will protect against metabolic dysfunction in a population at an increased risk. The purpose of this study was to investigate whether breastfeeding duration in infancy and current breakfast frequency are associated with A/L ratio and metabolic dysfunction in children and adolescents with obesity.The study cohort consisted of obese (body mass index ≥ 95th percentile) children and adolescents (n = 100, 46M). Fasting blood samples were taken to measure high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, insulin, glucose, adiponectin, and leptin levels. Weight, height, and blood pressure were also assessed. Breastfeeding history was obtained through the National Health and Nutrition Examination Survey of 2003-2004, and breakfast frequency was reported through the Gold Medal School Parent Questionnaire administered to parents.Of the 100 participants, 82% were breastfed as infants. Among the breastfed, 66% (n = 54) were breastfed for ≥ 6 months and 62% (n = 54) were breastfed exclusively for ≥ 6 months (4 parents could not recall duration of exclusive breastfeeding). Of thebreakfast responses collected (n = 46), most participants (59%, n = 27) reported consuming breakfast every day. There was no association between these diet factors and A/L ratio or the presence of metabolic dysfunction. Differences in A/L (p = 0.02) and leptin (p = 0.009) were noted between categorical breakfast frequencies when gender was controlled for, and there was a significant difference in BMI between categorical breakfast intakes (p = 0.02). There were no significant relationships in the linear model of breakfast. No association between A/L ratio and metabolic dysfunction was observed. In conclusion, breastfeeding duration and breakfast frequency do not appear to influence A/L ratio or metabolic dysfunction in this population of obese children and adolescents.

Subjects/Keywords: Adiponectin; Breakfast; Breastfeeding; Leptin; Nutrition; Obesity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Urban, B. M. (2013). The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3476/rec/2642

Chicago Manual of Style (16^th Edition):

Urban, Brittney Marie. “The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese.” 2013. Masters Thesis, University of Utah. Accessed August 21, 2019. http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3476/rec/2642.

MLA Handbook (7^th Edition):

Urban, Brittney Marie. “The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese.” 2013. Web. 21 Aug 2019.

Vancouver:

Urban BM. The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese. [Internet] [Masters thesis]. University of Utah; 2013. [cited 2019 Aug 21]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3476/rec/2642.

Council of Science Editors:

Urban BM. The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese. [Masters Thesis]. University of Utah; 2013. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3476/rec/2642

8. Brazaca, Laís Canniatti. Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2.

Degree: Mestrado, Física Aplicada, 2015, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22042015-152351/ ;

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A obesidade tem aumentado dramaticamente nos últimos anos, tornando-se o maior fator de risco para o desenvolvimento de doenças cardiovasculares, vários tipos de câncer, e… (more)

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A obesidade tem aumentado dramaticamente nos últimos anos, tornando-se o maior fator de risco para o desenvolvimento de doenças cardiovasculares, vários tipos de câncer, e também do Diabetes mellitus tipo 2 (DM 2). A associação da obesidade com o desenvolvimento do DM 2 pode ser explicada, em parte, pela secreção alterada pelo tecido adiposo de adipocinas, como a adiponectina, um hormônio com propriedades antiinflamatórias e de sensibilização à insulina. O excesso do tecido adiposo regula negativamente a secreção de adiponectina, o que ocorre de 10 a 20 anos antes da hiperglicemia crônica, fazendo com que este hormônio seja um bom indicador para o diagnóstico preditivo de DM 2. A concentração de adiponectina em plasma é usualmente aferida por ELISA, método não amplamente utilizado devido ao seu alto preço, necessidade de pessoal qualificado e material e, dessa maneira, ainda praticamente inacessível à grande parcela da população. Sendo assim, o desenvolvimento de novas metodologias e de ferramentas de diagnóstico confiáveis e de baixo custo (que possam ser implementados pelo Sistema Único de Saúde SUS) é imprescindível. Aqui, desenvolvemos um biossensor simples e de baixo custo para detecção de adiponectina baseado na espectroscopia de impedância eletroquímica (EIS) ou voltametría cíclica (CV) usando plataformas nanoestruturadas contendo receptores transmembrana de adiponectina (AdipoR1 e AdipoR2) ou anticorpos anti-AdipoQ imobilizados em eletrodos de ouro. Os melhores resultados foram obtidos através do uso dos receptores AdipoR1/R2 em conjunto com CV. Neste caso, os biossensores foram capazes de detectar concentrações de adiponectina tão baixas quanto 7 nmol L-1 com uma faixa linear entre 0,01 a 0,75 mol L-1 de adiponectina, R²=0,992. O dispositivo apresentou ótima seletividade, estabilidade e reprodutibilidade (ca. 1,7% para n=3). Além disso, em amostras de plasma humano, o biossensor obteve resultados muito próximos aos obtidos pelo método pardão ELISA, com desvio de 14%. Esperamos que este estudo propicie maior acessibilidade ao diagnóstico preditivo do DM 2 através de dispositivos mais baratos, rápidos e portáteis e que um maior número indivíduos possam ser alertados e orientados, evitando o desenvolvimento posterior da doença.

Obesity has increased dramatically in the last few years, becoming the biggest risk factor for development of cardiovascular diseases, several types of cancer and also the type 2 diabetes mellitus (DM 2). The association between obesity and DM 2 can be partially explained by the altered secretion of adiponectin hormone by the adipose tissue, which presents anti-inflammatory and insulin sensitizing properties. The excess of adipose tissue regulates negatively adiponectin secretion, which occurs 10 to 20 years before chronic hyperglycemia, making this hormone a great biomarker for predictive DM 2 diagnosis. Adiponectin plasma concentration is usually measured by ELISA, a method not widely used due to its high cost, personal and material demand, being, therefore, not accessible to part…

Advisors/Committee Members: Zucolotto, Valtencir.

Subjects/Keywords: Adiponectin; Adiponectina; Biosensor; Biossensor; Diabetes; Diabetes

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APA (6^th Edition):

Brazaca, L. C. (2015). Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22042015-152351/ ;

Chicago Manual of Style (16^th Edition):

Brazaca, Laís Canniatti. “Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2.” 2015. Masters Thesis, University of São Paulo. Accessed August 21, 2019. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22042015-152351/ ;.

MLA Handbook (7^th Edition):

Brazaca, Laís Canniatti. “Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2.” 2015. Web. 21 Aug 2019.

Vancouver:

Brazaca LC. Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2. [Internet] [Masters thesis]. University of São Paulo; 2015. [cited 2019 Aug 21]. Available from: http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22042015-152351/ ;.

Council of Science Editors:

Brazaca LC. Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2. [Masters Thesis]. University of São Paulo; 2015. Available from: http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22042015-152351/ ;

9. Ζαχαριουδάκη, Βασιλική. Επίδραση των νευροπεπτιδίων της οικογένειας του εκλυτικού παράγοντα της κορτικοτροπίνης (CRF) και της λιποκίνης αδιπονεκτίνη στην τοπική ρύθμιση της φλεγμονής.

Degree: 2009, University of Crete (UOC); Πανεπιστήμιο Κρήτης

URL: http://hdl.handle.net/10442/hedi/18296

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CRF and Urocortins are major regulators of the inflammatory process. When released at the site of inflammation from nerve terminals, epithelial and immune cells, they… (more)

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CRF and Urocortins are major regulators of the inflammatory process. When released at the site of inflammation from nerve terminals, epithelial and immune cells, they affect directly the immune system, at the level of macrophage activation, exerting either pro-inflammatory or anti-inflammatory effects, depended on several factors among which the presence of other immuno-modulatory molecules at the site of inflammation is included. Adiponectin serves as such a molecule and its principal effect on macrophages is accepted to be anti-inflammatory. In this study, we investigate the effect of CRF and Urocortins on the regulation of adiponectin receptors AdipoR1 and AdipoR2 and on the adiponectin- and LPS-induced production of pro-inflammatory cytokines in macrophages. We found that CRF and Urocortins did not affect the effect of adiponectin on macrophages. The anti-inflammatory effects of adiponectin are believed to be exerted via macrophages, through suppression of the production of pro-inflammatory cytokines in response to LPS, via yet unknown signaling pathways. In this study we investigate the molecular mechanisms of macrophage tolerance driven by adiponectin. We show that macrophage tolerance did not occur at the adiponectin receptor level. At the early phase of the inflammatory response adiponectin regulates its magnitude via the activation of PI3K/Akt pathway, which in turn suppresses the activation of LPS-induced signaling pathways, such as the MEK/ERK pathway. In the long term, adiponectin induces the expression of IRAK-M protein, which acts as a dominant negative molecule on the activation of TLR-induced pathways, thus providing a late-stage potential mechanism through which adiponectin promotes tolerance of macrophages to LPS. Homologous deletion of IRAK-M abolished the tolerogenic properties of gAd, in terms of LPS-induced pro-inflammatory cytokine production from macrophages. Analysis of IRAK-M expression in human peripheral blood cells confirmed that serum adiponectin was positively associated with IRAK-M levels and negatively associated with the responsiveness of the cells to LPS. Finally, we show that adiponectin-induced glucose uptake from macrophages is necessary for the induction of macrophage tolerance, thus implying that the “tolerogenic state” is an active, energy-consuming process.

Τα νευροπεπτίδια της οικογένειας CRF, που απελευθερώνονται σε περιοχές φλεγμονής περιφερικά, επηρεάζουν άμεσα το ανοσοποιητικό σύστημα δρώντας με αυτοκρινή ή/και με παρακρινή τρόπο ενισχύοντας, συνήθως, τη φλεγμονώδη αντίδραση. Ωστόσο, είναι πιθανό, να έχουν και αντι-φλεγμονώδη δράση βραχυπρόθεσμα και παροδικά, μέσω της επίδρασής τους στα μακροφάγα. Η έκβαση της επίδρασης των CRF νευροπεπτιδίων στα μακροφάγα εξαρτάται από ποικίλους παράγοντες, όπως η παρουσία ή όχι άλλων μορίων που, πιθανό να, επηρεάζουν τη δραστηριότητα των κυττάρων. Ένα τέτοιο μόριο είναι η αδιπονεκτίνη, η οποία εντοπίζεται περιφερικά σε περιοχές φλεγμονής και αναφέρεται ότι η δράση της επί των κυττάρων του ανοσοποιητικού συστήματος είναι…

Subjects/Keywords: Αδιπονεκτίνη; Μακροφάγα; Φλεγμονές; Adiponectin; Macrophages; Inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ζαχαριουδάκη, . �. (2009). Επίδραση των νευροπεπτιδίων της οικογένειας του εκλυτικού παράγοντα της κορτικοτροπίνης (CRF) και της λιποκίνης αδιπονεκτίνη στην τοπική ρύθμιση της φλεγμονής. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/18296

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ζαχαριουδάκη, Βασιλική. “Επίδραση των νευροπεπτιδίων της οικογένειας του εκλυτικού παράγοντα της κορτικοτροπίνης (CRF) και της λιποκίνης αδιπονεκτίνη στην τοπική ρύθμιση της φλεγμονής.” 2009. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed August 21, 2019. http://hdl.handle.net/10442/hedi/18296.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ζαχαριουδάκη, Βασιλική. “Επίδραση των νευροπεπτιδίων της οικογένειας του εκλυτικού παράγοντα της κορτικοτροπίνης (CRF) και της λιποκίνης αδιπονεκτίνη στην τοπική ρύθμιση της φλεγμονής.” 2009. Web. 21 Aug 2019.

Vancouver:

Ζαχαριουδάκη �. Επίδραση των νευροπεπτιδίων της οικογένειας του εκλυτικού παράγοντα της κορτικοτροπίνης (CRF) και της λιποκίνης αδιπονεκτίνη στην τοπική ρύθμιση της φλεγμονής. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2009. [cited 2019 Aug 21]. Available from: http://hdl.handle.net/10442/hedi/18296.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ζαχαριουδάκη �. Επίδραση των νευροπεπτιδίων της οικογένειας του εκλυτικού παράγοντα της κορτικοτροπίνης (CRF) και της λιποκίνης αδιπονεκτίνη στην τοπική ρύθμιση της φλεγμονής. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2009. Available from: http://hdl.handle.net/10442/hedi/18296

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

10. Michalakis, Konstantinos. Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους.

Degree: 2016, University of Crete (UOC); Πανεπιστήμιο Κρήτης

URL: http://hdl.handle.net/10442/hedi/37374

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AIM: Adiponectin, an adipose tissue derived hormone with insulin-sensitizing effects, has been inversely associated to several hormonally-dependent malignancies. Prostate cancer is associated with low levels… (more)

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AIM: Adiponectin, an adipose tissue derived hormone with insulin-sensitizing effects, has been inversely associated to several hormonally-dependent malignancies. Prostate cancer is associated with low levels of adiponectin which have been proposed as an independent risk factor for this malignancy. Aim of the current study was to examine whether hypoadiponectinemia in prostate is associated with to insulin resistance. Experimental design: Plasma samples and covariate data in the context of a case-control study of 300 Greek men were evaluated including 75 prostate cancer patients, 75 patients with benign prostatic hyperplasia (BPH), and 150 age-matched healthy controls. Results: Prostate cancer patients had significantly lower plasma adiponectin levels compared to the other two groups i.e. BPH patients and healthy controls (7.4±5ng/ml versus 11.5±6.4ng/ml and 12.8±8ng/ml, respectively). On the other hand, no statistically significant differences were found between prostate cancer patients and the other two groups for both HOMA-IR and QUICKI (p-value= 0.551). As expected, in all three groups, the levels of adiponectin correlated negatively with HOMA-IR (rho=-0.214, p-value=0.006), QUICKI (rho=0.214, p-value=0.006) and insulin levels (rho=0.942, p-value<0.001). Conclusion: In spite to what would have been expected from the relevant literature, our data suggest that the hypoadiponectinemia in prostatic cancer does not appear to be associated to insulin resistance.

Συμπέρασμα: Παρά τα όρια του σχεδιασμού της μελέτης μας, η πρώτη παγκοσμίως μελέτη στην οποία γίνεται σύγκριση των επιπέδων αδιπονεκτίνης και των παραμέτρων της ινσουλινοαντοχής σε ένα επαρκές δείγμα ασθενών με καρκίνο του προστάτη, σε μια προσπάθεια να γίνει διάκριση μεταξύ της απευθείας per se δράση της αδιπονεκτίνης στον καρκίνο του προστάτη, σε σύγκριση με την καλά μέχρι τώρα μελετηθείσα δράση μέσω οδών ευαισθησίας στην ινσουλίνη. Η επίπτωση της αδιπονεκτίνης σε καρκινικούς ασθενείς έχει ήδη τεκμηριωθεί από την ομάδα μας και άλλες ομάδες. Παρ 'όλα αυτά, αυτή είναι η πρώτη άμεση απόπειρα ποτέ να απομονώσει την αδιπονεκτίνη από την ευαισθησία στην ινσουλίνη και η πρώτη έμμεση απόδειξη ότι η αδιπονεκτίνη μπορεί να ενεργεί per se στην παθογένεση του καρκίνου μέσω μιας από τις ανωτέρω οδούς, αλλά όχι εκείνη της αντίστασης στην ινσουλίνη. Αν περαιτέρω μελέτες σε άλλες κακοήθειες δείχνουν τα ίδια αποτελέσματα, αυτό θα ενισχύσει μια τέτοια συσχέτιση. Εν ολίγοις, δείξαμε ότι υψηλότερες συγκεντρώσεις αντιπονεκτίνης στο πλάσμα που σχετίζονται με μειωμένο κίνδυνο καρκίνου του προστάτη σε αυτόν τον πληθυσμό των Ελλήνων ανδρών και ότι όλες οι συσχετίσεις υπάρχουν ανεξάρτητα από το μονοπάτι της ευαισθησίας στην ινσουλίνη, η οποία μέχρι στιγμής έχει προταθεί να είναι η κύρια συνέπεια της αντιπονεκτίνης στην καρκινογένεση. Αυτά τα αποτελέσματα υποδηλώνουν ότι η αδιπονεκτίνη μπορεί να εμπλέκεται στην ανάπτυξη του καρκίνου του προστάτη per se.

Subjects/Keywords: Αδιπονεκτίνη; Καρκίνος προστάτη; Adiponectin Receptors; Prostate cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Michalakis, K. (2016). Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/37374

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Michalakis, Konstantinos. “Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους.” 2016. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed August 21, 2019. http://hdl.handle.net/10442/hedi/37374.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Michalakis, Konstantinos. “Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους.” 2016. Web. 21 Aug 2019.

Vancouver:

Michalakis K. Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2016. [cited 2019 Aug 21]. Available from: http://hdl.handle.net/10442/hedi/37374.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Michalakis K. Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2016. Available from: http://hdl.handle.net/10442/hedi/37374

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

11. SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE, STRUCTURES. The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human .

Degree: 2012, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/2882

► Background: The association of obesity with development of type 2 diabetes may be partly mediated by altered secretion of adipokines by adipose tissue. Greater adiposity… (more)

Subjects/Keywords: adiponectin; adipose tissue; type 2 diabetes

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE, S. (2012). The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/2882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE, STRUCTURES. “The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human .” 2012. Thesis, Addis Ababa University. Accessed August 21, 2019. http://etd.aau.edu.et/dspace/handle/123456789/2882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE, STRUCTURES. “The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human .” 2012. Web. 21 Aug 2019.

Vancouver:

SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE S. The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human . [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2019 Aug 21]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE S. The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human . [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cincinnati

12. Ahire, Shwetal. Maternal adiposity and plasma concentrations of leptin and adiponectin.

Degree: MS, Allied Health Sciences : Nutrition, 2009, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1250701408

► <b>Objective:</b> The purpose of this project was to determine the relationship of maternal adiposity to the adipokines, adiponectin and leptin.Design: Prospective cohort study.<b>Subjects:</b> Healthy, non-smoking… (more)

Subjects/Keywords: Nutrition; pregnancy; skinfold; leptin; adiponectin; obesity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ahire, S. (2009). Maternal adiposity and plasma concentrations of leptin and adiponectin. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1250701408

Chicago Manual of Style (16^th Edition):

Ahire, Shwetal. “Maternal adiposity and plasma concentrations of leptin and adiponectin.” 2009. Masters Thesis, University of Cincinnati. Accessed August 21, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1250701408.

MLA Handbook (7^th Edition):

Ahire, Shwetal. “Maternal adiposity and plasma concentrations of leptin and adiponectin.” 2009. Web. 21 Aug 2019.

Vancouver:

Ahire S. Maternal adiposity and plasma concentrations of leptin and adiponectin. [Internet] [Masters thesis]. University of Cincinnati; 2009. [cited 2019 Aug 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1250701408.

Council of Science Editors:

Ahire S. Maternal adiposity and plasma concentrations of leptin and adiponectin. [Masters Thesis]. University of Cincinnati; 2009. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1250701408

Louisiana State University

13. Wang, Yanning. TNF-alpha inhibition of adiponectin expression by targeting PPAR-gamma and C/EBP in adipocytes.

Degree: MS, Human Ecology, 2009, Louisiana State University

URL: etd-07012009-181133 ; https://digitalcommons.lsu.edu/gradschool_theses/3684

► Chronic inflammation is involved in the adipose tissue dysfunction through regulation of endocrine and storage function of adipocytes. As a representative proinflammatory cytokine, TNF-α was… (more)

Subjects/Keywords: C/EBP; PPAR-gamma; TNF-alpha; Adiponectin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wang, Y. (2009). TNF-alpha inhibition of adiponectin expression by targeting PPAR-gamma and C/EBP in adipocytes. (Masters Thesis). Louisiana State University. Retrieved from etd-07012009-181133 ; https://digitalcommons.lsu.edu/gradschool_theses/3684

Chicago Manual of Style (16^th Edition):

Wang, Yanning. “TNF-alpha inhibition of adiponectin expression by targeting PPAR-gamma and C/EBP in adipocytes.” 2009. Masters Thesis, Louisiana State University. Accessed August 21, 2019. etd-07012009-181133 ; https://digitalcommons.lsu.edu/gradschool_theses/3684.

MLA Handbook (7^th Edition):

Wang, Yanning. “TNF-alpha inhibition of adiponectin expression by targeting PPAR-gamma and C/EBP in adipocytes.” 2009. Web. 21 Aug 2019.

Vancouver:

Wang Y. TNF-alpha inhibition of adiponectin expression by targeting PPAR-gamma and C/EBP in adipocytes. [Internet] [Masters thesis]. Louisiana State University; 2009. [cited 2019 Aug 21]. Available from: etd-07012009-181133 ; https://digitalcommons.lsu.edu/gradschool_theses/3684.

Council of Science Editors:

Wang Y. TNF-alpha inhibition of adiponectin expression by targeting PPAR-gamma and C/EBP in adipocytes. [Masters Thesis]. Louisiana State University; 2009. Available from: etd-07012009-181133 ; https://digitalcommons.lsu.edu/gradschool_theses/3684

University of Miami

14. Rossetti, Maria Agustina. The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition.

Degree: PhD, Psychology (Arts and Sciences), 2015, University of Miami

URL: https://scholarlyrepository.miami.edu/oa_dissertations/1491

► Objective: BMI in midlife has been shown to increase the risk of dementia later in life, independent of other cardiovascular comorbidities. However, this association reverses… (more)

▼ Objective: BMI in midlife has been shown to increase the risk of dementia later in life, independent of other cardiovascular comorbidities. However, this association reverses direction later in life (age 60-70 years) such that older individuals with dementia have lower BMIs than those without dementia. Adiponectin, an anti-inflammatory cytokine released by adipose tissue, is negatively correlated with body weight and BMI. Adiponectin exists in low molecular weight (LMW) and high molecular weight (HMW) isoforms. It has been proposed that LMW adiponectin may have central effects. This study examined the association of circulating adiponectin isoforms with BMI, memory performance, and brain morphology (hippocampus and white mater hypointensities), in older individuals with memory complaints. Participants and Methods: Ninety-two participants (Mage=75, SD=9) from the University of Miami Memory Disorders Clinic consented to donation of a blood sample and were included for analyses in the present study. Adiponectin immunoassays for adiponectin isoforms were developed with monoclonal antibodies. Memory was measured with the Logical Memory test from the Uniform Data Set (UDS) of the National Alzheimer’s Coordinating Center. Scores were adjusted for demographic factors. Results: Linear regression analyses revealed that BMI predicted total adiponectin (b=-.06, p<.05) and LMW adiponectin (b=-.03, p<.05). Elevated levels total and LMW adiponectin significantly predicted poor immediate memory performance, but only for women (p<.05). We found no significant association with delayed verbal memory. There were also no significant associations among adiponectin isoforms, hippocampal volume, and white matter hypodensities. Conclusions: This study provides preliminary evidence that LMW may exert central effects and serve as an important biomarker of the aging process and cognition. This investigation also highlights an important gender difference in biomarkers of neurodegenerative disease. Further research in larger samples is needed. Advisors/Committee Members: Phil McCabe, Bonnie Levin, Maria Llabre, Armando Mendez, Neil Schneiderman, Clinton Wright.

Subjects/Keywords: adipose tissue; adiponectin; HMW; LMW; cognition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rossetti, M. A. (2015). The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition. (Doctoral Dissertation). University of Miami. Retrieved from https://scholarlyrepository.miami.edu/oa_dissertations/1491

Chicago Manual of Style (16^th Edition):

Rossetti, Maria Agustina. “The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition.” 2015. Doctoral Dissertation, University of Miami. Accessed August 21, 2019. https://scholarlyrepository.miami.edu/oa_dissertations/1491.

MLA Handbook (7^th Edition):

Rossetti, Maria Agustina. “The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition.” 2015. Web. 21 Aug 2019.

Vancouver:

Rossetti MA. The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition. [Internet] [Doctoral dissertation]. University of Miami; 2015. [cited 2019 Aug 21]. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1491.

Council of Science Editors:

Rossetti MA. The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition. [Doctoral Dissertation]. University of Miami; 2015. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1491

15. Prioriello, Michelle. The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance.

Degree: MSc -MS, Biology, 2018, York University

URL: http://hdl.handle.net/10315/34349

► Recent research is aiming to elucidate the molecular mechanisms of metabolic syndrome-associated diseases. This study investigates iron overload-induced adiponectin resistance in cardiovascular disease and diabetes.… (more)

Subjects/Keywords: Physiology; Iron overload; Adiponectin; Adiponectin resistance; Iron; Heart; Muscle; Adiponectin signalling; Adiponectin regulation; Mechanism; FOXO1 transcription factor; FOXO1; Diabetes; Heart disease; Heart failure; Cardiac dysfunction; Glucose metabolism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Prioriello, M. (2018). The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance. (Masters Thesis). York University. Retrieved from http://hdl.handle.net/10315/34349

Chicago Manual of Style (16^th Edition):

Prioriello, Michelle. “The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance.” 2018. Masters Thesis, York University. Accessed August 21, 2019. http://hdl.handle.net/10315/34349.

MLA Handbook (7^th Edition):

Prioriello, Michelle. “The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance.” 2018. Web. 21 Aug 2019.

Vancouver:

Prioriello M. The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance. [Internet] [Masters thesis]. York University; 2018. [cited 2019 Aug 21]. Available from: http://hdl.handle.net/10315/34349.

Council of Science Editors:

Prioriello M. The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance. [Masters Thesis]. York University; 2018. Available from: http://hdl.handle.net/10315/34349

University of Toronto

16. Ehsan, Mehroz. Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/71230

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Monocyte-derived microparticles (MPs) have been suggested to link cardiovascular risk factors to vascular injury. We hypothesized that adiponectin, an anti-inflammatory and vasculoprotective adipokine, limits the… (more)

Subjects/Keywords: Adiponectin; AMPK; inflammation; Microparticles; microvesicles; 0564

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ehsan, M. (2015). Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/71230

Chicago Manual of Style (16^th Edition):

Ehsan, Mehroz. “Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction.” 2015. Masters Thesis, University of Toronto. Accessed August 21, 2019. http://hdl.handle.net/1807/71230.

MLA Handbook (7^th Edition):

Ehsan, Mehroz. “Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction.” 2015. Web. 21 Aug 2019.

Vancouver:

Ehsan M. Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2019 Aug 21]. Available from: http://hdl.handle.net/1807/71230.

Council of Science Editors:

Ehsan M. Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/71230

17. 田邊, 順一. Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用.

Degree: 博士（歯学）, 2016, Osaka Dental University / 大阪歯科大学

URL: http://id.nii.ac.jp/1392/00000063/

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Adiponectin, an adipocyte-derived biologically active molecule, is a ∼30-kDa polypeptide containing an N-terminal signal sequence, variable domain, collagen-like domain, and C-terminal globular domain. Previously we… (more)

Subjects/Keywords: adiponectin; collagen-like peptide; osteoblast; microarray; adiponectin; collagen-like peptide; osteoblast; microarray

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

田邊, �. (2016). Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用. (Thesis). Osaka Dental University / 大阪歯科大学. Retrieved from http://id.nii.ac.jp/1392/00000063/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

田邊, 順一. “Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用.” 2016. Thesis, Osaka Dental University / 大阪歯科大学. Accessed August 21, 2019. http://id.nii.ac.jp/1392/00000063/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

田邊, 順一. “Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用.” 2016. Web. 21 Aug 2019.

Vancouver:

田邊 �. Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用. [Internet] [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. [cited 2019 Aug 21]. Available from: http://id.nii.ac.jp/1392/00000063/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

田邊 �. Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用. [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. Available from: http://id.nii.ac.jp/1392/00000063/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Jawaharlal Nehru University

18. Sanal, M G. Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -.

Degree: Medicine, 2008, Jawaharlal Nehru University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/17526

None

References p.131-144 , Appendix iii-xxii

Advisors/Committee Members: Sarin, Shiv Kumar.

Subjects/Keywords: Medicine; Molecular; adiponectin; nonalcoholic; diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sanal, M. G. (2008). Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -. (Thesis). Jawaharlal Nehru University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/17526

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sanal, M G. “Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -.” 2008. Thesis, Jawaharlal Nehru University. Accessed August 21, 2019. http://shodhganga.inflibnet.ac.in/handle/10603/17526.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sanal, M G. “Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -.” 2008. Web. 21 Aug 2019.

Vancouver:

Sanal MG. Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -. [Internet] [Thesis]. Jawaharlal Nehru University; 2008. [cited 2019 Aug 21]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/17526.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sanal MG. Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -. [Thesis]. Jawaharlal Nehru University; 2008. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/17526

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

19. Ocon-Grove, Olga M. CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS.

Degree: PhD, Physiology, 2008, Penn State University

URL: https://etda.libraries.psu.edu/catalog/8936

► Adiponectin is an adipokine hormone which influences several aspects of metabolism, including glucose utilization, insulin sensitivity, lipid synthesis and energy homeostasis by signaling through two… (more)

▼ Adiponectin is an adipokine hormone which influences several aspects of metabolism, including glucose utilization, insulin sensitivity, lipid synthesis and energy homeostasis by signaling through two receptors, AdipoR1 and AdipoR2. A decrease in circulating adiponectin levels, as occurs in obesity in humans, has been associated with the development of insulin resistance, type 2 diabetes and tumor development. The main objectives of the current studies are: (1) To characterize the expression of adiponectin and its receptors in the chicken ovary and testis and (2) To explore their potential role in chicken ovarian tumorigenesis. RT-PCR analyses of RNA isolated from chicken follicular granulosa cells (GC) revealed the presence of AdipoR1 and AdipoR2 mRNA, while adiponectin mRNA was not detected; however, all three transcripts were found in homogenates of whole ovary. Using immunohistochemistry adiponectin-immunoreactive (ir) cells were localized to follicular theca cells (TC) but not the GC, while both AdipoR1-ir and AdipoR2-ir cells were present in TC and GC. Treatment of sexually immature chicken hens with progesterone (P4) decreased ovarian adiponectin mRNA concentration, while estradiol (E2) or P4/E2 treatment increased adiponectin mRNA expression. Estradiol treatment increased ovarian AdipoR1 mRNA quantity, while AdipoR2 mRNA quantity was not affected by any treatment. Quantitative real-time PCR (qPCR) analysis revealed T-cadherin, a putative receptor for high molecular weight adiponectin, and AdipoR1 mRNA were down-regulated in chicken ovarian tumors, while neither ovarian adiponectin nor T-cadherin protein quantities were altered by the presence of ovarian tumors, according to Western blot analysis. Using qPCR, testicular AdipoR1 and AdipoR2 mRNA abundance were 8.3- and 9-fold higher in adult chickens compared to prepubertal chickens, respectively. Adiponectin-ir and AdipoR1-ir cells were detected in testicular peritubular and Leydig cells, while AdipoR2-ir cells were localized in the seminiferous tubule adluminal and luminal compartments and interstitial cells. In particular, Sertoli cell syncytia, round and elongating spermatids, spermatozoa and Leydig cells exhibited strong AdipoR2-immunoreactivity. Collectively, these findings demonstrate that adiponectin and its receptors are present and regulated in cell-specific manner and maybe involved in chicken reproduction. Future studies should focus on altering adiponectin signaling for improving reproductive efficiency in chickens as well as gaining a better understanding of the role adiponectin and its receptors have in reproductive functions.

Subjects/Keywords: Ovary; Adiponectin; Testis

…viii MODEL DEPICTING THE ROLE OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN TESTIS… …47 Figure 2.9. Adiponectin structure and multimerization. 48 Figure 2.10. Adiponectin… …receptors. 49 Figure 2.11. Adiponectin signaling in the muscle and liver. 50 Figure 2.12… …Potential pathways for adiponectin signaling in ovarian follicles. 51 Figure 3.1. RT-PCR… …analysis of adiponectin, AdipoR1 and AdipoR2 gene expression in sexually mature chicken ovary…

10 more images…

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ocon-Grove, O. M. (2008). CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS. (Doctoral Dissertation). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/8936

Chicago Manual of Style (16^th Edition):

Ocon-Grove, Olga M. “CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS.” 2008. Doctoral Dissertation, Penn State University. Accessed August 21, 2019. https://etda.libraries.psu.edu/catalog/8936.

MLA Handbook (7^th Edition):

Ocon-Grove, Olga M. “CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS.” 2008. Web. 21 Aug 2019.

Vancouver:

Ocon-Grove OM. CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS. [Internet] [Doctoral dissertation]. Penn State University; 2008. [cited 2019 Aug 21]. Available from: https://etda.libraries.psu.edu/catalog/8936.

Council of Science Editors:

Ocon-Grove OM. CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS. [Doctoral Dissertation]. Penn State University; 2008. Available from: https://etda.libraries.psu.edu/catalog/8936

20. Σούρλας, Δημήτριος. Ghrelin και αναπαραγωγή.

Degree: 2011, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/25011

► Introduction: Conflicting data have been reported about the role of exogenous and endogenous ovarian steroids on the secretion of ghrelin, resistin, and adiponectin . The… (more)

▼ Introduction: Conflicting data have been reported about the role of exogenous and endogenous ovarian steroids on the secretion of ghrelin, resistin, and adiponectin . The objective of the present study was to investigate changes of ghrelin, resistin, and adiponectin levels in the circulation during a) the normal menstrual cycle and b) in ovarian stimulation with FSH for multiple follicular development. Material & methods: a) Eight healthy normally cycling women were observed during a whole menstrual cycle. Daily blood samples were taken every morning, after overnight fasting, from day 2 of the cycle until the next menstrual period. Plasma acylated and unacylated ghrelin, and serum resistin, adiponectin, FSH, LH, E2, and P levels were measured in all blood samples. b) Twenty healthy normally cycling women, aged 31.2±0.8 years with BMI 24.5±1.9 kg/m2, were stimulated in a single cycle with recombinant FSH in a GnRH agonist short protocol for IVF/ICSI due to male infertility. Luteal phase support with vaginal progesterone was given to all women. Blood samples were taken in the morning, after overnight fasting, on cycle day 2 before the commencement of FSH and GnRH agonist injections, on cycle days 5 and 7 and on the days of HCG injection, oocyte retrieval (OR), embryo transfer (ET, two days after the OR) as well as 7 and 12 days following ET. Plasma total ghrelin and serum adiponectin, resistin, FSH, LH, E2, and progesterone levels were measured in all blood samples. Results: a) In all women serum FSH, LH, E2, and P levels, normalized to the midcycle peak LH value, showed the typical changes of the normal menstrual cycle. Acylated and unacylated ghrelin, resistin, and adiponectin levels did not change significantly during the whole menstrual cycle. b) Plasma total ghrelin was 667.9±44 pg/ml before the stimulation with FSH and remained unchanged during the whole study period. Serum adiponectin levels were 10.3±1.0 μg/ml before the stimulation with FSH, remaining stable during the stimulation period until the day of ET and decreasing significantly on days 7 and 12 (8.6±0.8 μg/ml) post-ET (p<0.001). Serum resistin levels were 3.2±0.3 ng/ml before the FSH administration increasing gradually until the day of ET (4.2±0.2 ng/ml) (p<0.05), remaining unchanged on day 7 post-ET and decreasing significantly on day 12 post-ET (3.6±0.2 ng/ml, p<0.05). Conclusions: The present study shows for the first time that plasma ghrelin and serum resistin and adiponectin levels do not change significantly during the normal menstrual cycle. It is suggested that ovarian steroid dynamics during the cycle have no effect on the secretion of these substances. It is also shown for the first time that plasma ghrelin levels did not change significantly during ovarian stimulation for IVF/ICSI-ET. Serum resistin levels increased during the stimulation period while adiponectin levels remained stable decreasing during the luteal phase. It is suggested that ovarian steroid dynamics in superovulated cycles control differentially resistin and adiponectin…

Subjects/Keywords: Γκρελίνη; Αντιπονεκτίνη; Ρεζιστίνη; Αναπαραγωγή; Ghrelin; Adiponectin; Resistin; Reproduction

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APA (6^th Edition):

Σούρλας, . �. (2011). Ghrelin και αναπαραγωγή. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/25011

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Σούρλας, Δημήτριος. “Ghrelin και αναπαραγωγή.” 2011. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed August 21, 2019. http://hdl.handle.net/10442/hedi/25011.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Σούρλας, Δημήτριος. “Ghrelin και αναπαραγωγή.” 2011. Web. 21 Aug 2019.

Vancouver:

Σούρλας �. Ghrelin και αναπαραγωγή. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2011. [cited 2019 Aug 21]. Available from: http://hdl.handle.net/10442/hedi/25011.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Σούρλας �. Ghrelin και αναπαραγωγή. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2011. Available from: http://hdl.handle.net/10442/hedi/25011

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Τσιάκου, Αφροδίτη. Σημασία της αντιπονεκτίνης του ορού στην οξεία φάση του ισχαιμικού εγκεφαλικού επεισοδίου.

Degree: 2013, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/29698

► ObjectiveThe present study aimed to investigate the association between serum adiponectin levels atthe acute phase of ischemic stroke, and (i) cardiometabolic parameters, (ii) inflammationmarkers, (iii)… (more)

▼ ObjectiveThe present study aimed to investigate the association between serum adiponectin levels atthe acute phase of ischemic stroke, and (i) cardiometabolic parameters, (ii) inflammationmarkers, (iii) stroke severity and (iv) one-year outcome (survival).Patients and methodsAll subjects admitted with a diagnosis of first-ever ischemic stroke were prospectivelyevaluated for inclusion in the study. Patients with transient ischemic attack were excluded.Participants were followed until death or the completion of one year after index stroke.Diagnosis was documented by brain computed tomography performed within the first 72hours and infarct volume was calculated. Stroke severity was assessed by the NationalInstitutes of Health Stroke Scale (NIHSS). Serum adiponectin concentration was evaluated bysandwitch ELISA at baseline and one year after index stroke. C-reactive protein (CRP) was alsodetermined by ELISA in a subgroup of patients.Comparisons between groups were made by using i) χ2 test with Yates’ correction or Fischerexact test for categorical data, ii) unpaired Student t-test or one-way ANOVA for continuousnormally distributed variables, and ii) Mann-Whitney or Kruskal Wallis test for continuous nonnormallydistributed variables. The Kaplan-Meier technique was applied in survival analysis,and the Cox proportional hazards model was used to evaluate the relationship between riskfactors and prognosis.ResultsData from 160 subjects (55% males, mean age 70.1±13.8 years, body mass index [BMI]27.8±4.3 Kg/m2, 66.2% non smokers) were analysed. Hypertension was present at 73.1% of theparticipants, while dyslipidemia, type 2 diabetes mellitus and atrial fibrillation were lesscommon (43.1%, 35.6% and 33.8%, respectively). Coronary artery and peripheral artery diseaseaccounted for 38.1% and 10% of pre-existing cardiovascular disease respectively.Atherothrombotic stroke was the most common subtype (45%), followed closely bycardioembolic stroke (40%), whereas lacunar was infrequent (15%). The median adiponectinand CRP baseline values were 5.8 [range 0.3 to 19] μg/ml and 14 [range 2 to 41] mg/Lrespectively. The three groups that resulted from the stratification of patients according totertiles of adiponectin concentrations (<4 μg/ml, 4-7 μg/ml και >7 μg/ml, respectively) weresignificantly different in regard to clinical severity of ischemic stroke (median NIHSS score,P=0.003), infarct volume (P<0.001) and baseline CRP value (P<0.001). Adiponectin levels wereinversely related to age (Spearman’s [rho] r= - 0.24; P=0.003), BMI (r= - 0.26; P=0.001),baseline CRP value (r= - 0.67; P<0.001), infarct volume (r= - 0.43; P<0.001) and stroke severity (NIHSS score; r= - 0.36; P<0.001), whereas there was a significant positive association with oneyearsurvival (r= 0.31; P<0.001).Forty-seven patients (29.4%) died within the first year after index stroke, the majority (37/47,79%) due to cardiovascular (CV) events. About two thirds [29/47] of total deaths occurredwithin the first month after stroke. A greater probability of CV (45.2%) and all-cause…

Subjects/Keywords: Αντιπονεκτίνη; Ισχαιμικό εγκεφαλικό επεισόδιο; Πρόγνωση; Επιβίωση; Adiponectin; Ischemic stroke; Prognosis; Survival

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Τσιάκου, . �. (2013). Σημασία της αντιπονεκτίνης του ορού στην οξεία φάση του ισχαιμικού εγκεφαλικού επεισοδίου. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/29698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Τσιάκου, Αφροδίτη. “Σημασία της αντιπονεκτίνης του ορού στην οξεία φάση του ισχαιμικού εγκεφαλικού επεισοδίου.” 2013. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed August 21, 2019. http://hdl.handle.net/10442/hedi/29698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Τσιάκου, Αφροδίτη. “Σημασία της αντιπονεκτίνης του ορού στην οξεία φάση του ισχαιμικού εγκεφαλικού επεισοδίου.” 2013. Web. 21 Aug 2019.

Vancouver:

Τσιάκου �. Σημασία της αντιπονεκτίνης του ορού στην οξεία φάση του ισχαιμικού εγκεφαλικού επεισοδίου. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. [cited 2019 Aug 21]. Available from: http://hdl.handle.net/10442/hedi/29698.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Τσιάκου �. Σημασία της αντιπονεκτίνης του ορού στην οξεία φάση του ισχαιμικού εγκεφαλικού επεισοδίου. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2013. Available from: http://hdl.handle.net/10442/hedi/29698

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

22. Kryfti, Maria. Επίδραση της διακοπής καπνίσματος σε δείκτες φλεγμονής.

Degree: 2016, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/37689

►

Background: Evidence on the association of leptin and adiponectin and smoking is limited and discordant. Leptin and adiponectin represent the most abundant adipokines in human… (more)

▼

Background: Evidence on the association of leptin and adiponectin and smoking is limited and discordant. Leptin and adiponectin represent the most abundant adipokines in human plasma that play crucial roles in the pathophysiology of metabolic syndrome, atherosclerosis and insulin resistance. Leptin up-regulates the expression of several pro-inflammatory cytokines and is increased upon weight gain. Adiponectin has been shown to possess insulin sensitizing, anti -inflammatory and anti-atherogenic properties and is increased upon weight reduction. Our aim was to assess the effects of smoking cessation on serum leptin and adiponectin levels.Methods: We compared subjects who successfully quit smoking with 26 healthy non-smokers. Serum leptin and adiponectin levels, serum CRP and BMI were evaluated at the beginning of the study and at 3, 6 months after smoking cessation. Successful cessation was confirmed by an exhaled carbon monoxide measurement.Results: Among the sample group, 32 subjects had quitted smoking at 3 months and 29 subjects at 6 months. Samples’ leptin increased significantly from baseline to three months (mean change 3.76 ng/ml [95% CI 0.89, 6.64], p =0.012) and then decreased significantly from three to six months of smoking cessation (mean change -4,29ng/ml [95% CI -7.34, -6.64], p=0.078). Samples’ adiponectin increased significantly from baseline to three months of abstinence from smoking (mean change 2.34 [95% CI -0.05, 4.73], p=0.05).BMI was significantly increased (mean change 2.03kg/m² [95% CI 1.60, 2.46], p <0.05), while CRP decreased significantly from baseline to 6 months of smoking cessation (mean change -0.68 mg/dl [95% CI -1.06, - 0.30], p=0.001).Conclusions: Smoking quitters’ leptin levels appear to increase 3 months after smoking cessation and then decrease from 3 to 6 months of abstinence from smoking. Adiponectin levels increase during the first trimester of smoking cessation. The decrease in CRP levels indicates that the low grade inflammation observed in smokers is gradually restored. The alterations of serum leptin and adiponectin after 6 months of smoking cessation suggest the same but do not reach statistically significant levels. Weight gain and changes in fat distribution may attenuate the beneficial effects of smoking cessation.

Σκοπός: Τα δεδομένα που αφορούν την συσχέτιση της λεπτίνης και της αδιπονεκτίνης με το κάπνισμα είναι περιορισμένα και συγκρουόμενα. Η λεπτίνη και η αδιπονεκτίνη είναι οι αδιποκίνες που υπάρχουν σε μεγαλύτερη συγκέντρωση στο πλάσμα και κατέχουν σημαντικό ρόλο στην παθοφυσιολογία του μεταβολικού συνδρόμου, της αθηρωμάτωσης και της αντίστασης στην ινσουλίνη. Η λεπτίνη ενισχύει την έκφραση αρκετών κυτταροκινών φλεγμονής και αυξάνεται με την αύξηση του σωματικού βάρους. Η αδιπονεκτίνη έχει αντιφλεγμονώδη δράση και ενισχύει την ευαισθησία στην ινσουλίνη ενώ προστατεύει από την αθηρωματική νόσο. Η συγκέντρωση της αυξάνεται όταν παρατηρηθεί μείωση του σωματικού βάρους. Σκοπός της εργασίας ήταν η μελέτη της επίδρασης της διακοπής καπνίσματος στα επίπεδα λεπτίνης…

Subjects/Keywords: Λεπτίνη; Αδιπονεκτίνη; Διακοπή καπνίσματος; Κάπνισμα; Leptin; Adiponectin; Smoking cessation; Tobacco

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kryfti, M. (2016). Επίδραση της διακοπής καπνίσματος σε δείκτες φλεγμονής. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/37689

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kryfti, Maria. “Επίδραση της διακοπής καπνίσματος σε δείκτες φλεγμονής.” 2016. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed August 21, 2019. http://hdl.handle.net/10442/hedi/37689.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kryfti, Maria. “Επίδραση της διακοπής καπνίσματος σε δείκτες φλεγμονής.” 2016. Web. 21 Aug 2019.

Vancouver:

Kryfti M. Επίδραση της διακοπής καπνίσματος σε δείκτες φλεγμονής. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2016. [cited 2019 Aug 21]. Available from: http://hdl.handle.net/10442/hedi/37689.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kryfti M. Επίδραση της διακοπής καπνίσματος σε δείκτες φλεγμονής. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2016. Available from: http://hdl.handle.net/10442/hedi/37689

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

23. Χαλβατζάς, Νεκτάριος. Ο ρόλος των οιστρογόνων στην έκκριση της ghrelin, adiponecting και resistin σε γυναίκες.

Degree: 2009, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/18180

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Background: Data regarding the possible effects of estrogen on ghrelin, adiponectin and resistin secretion in humans are limited and contradictory. Aim: To investigate the effect… (more)

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Background: Data regarding the possible effects of estrogen on ghrelin, adiponectin and resistin secretion in humans are limited and contradictory. Aim: To investigate the effect of estradiol on ghrelin, adiponectin and resistin levels in normal pre- and post-menopausal women. Materials and Methods: A total of 21 women divided into three groups, i.e.13 normally cycling women (n=7, group 1 and n=6, group 2) and 8 postmenopausal women (group 3). Women of group 1 received increasing doses of estradiol (E2) through skin patches from cycle days 3 to 5. Women of group 2, underwent total abdominal hysterectomy plus bilateral salpingooophorectomy (TAH+BSO) on cycle day 3. Women of group 3 received per os increasing doses of E2 valerate for 15 days. Acylated ghrelin, adiponectin, resistin and E2 were measured in all blood samples. Results: In group 1, plasma ghrelin and serum adiponectin and resistin levels did not show any significant changes for the week following cycle day 3. In group 2, ghrelin, adiponectin and resistin levels were similar before and after TAH+BSO and remained stable during the first seven postoperative days. In group 3, no significant changes in plasma ghrelin and serum adiponectin and resistin levels were seen during the 15 days of E2 administration. Conclusions: The present study demonstrates for the first time that ghrelin, adiponectin and resistin values were not affected either by exogenous short-term estrogen administration to pre- and post-menopausal women or following ovariectomy in pre-menopausal women. It is suggested that ovarian hormones are not involved in the regulation of ghrelin, adiponectin and resistin secretion in women.

Εισαγωγή: Τα δεδομένα σχετικά με την επίδραση των οιστρογόνων στην έκκριση γκρελίνης, αντιπονεκτίνης και ρεσιστίνης στους ανθρώπους είναι περιορισμένα και αντικρουόμενα. Σκοπός της μελέτης: Η διερεύνηση των επιδράσεων της οιστραδιόλης στα επίπεδα της γκρελίνης, αντιπονεκτίνης και ρεσιστίνης σε φυσιολογικές προ- και μετεμμηνοπαυσιακές γυναίκες. Υλικά και μέθοδοι: Το υλικό μας αποτέλεσαν ένα σύνολο 21 γυναικών χωρισμένων σε 3 ομάδες. Οι 13 γυναίκες είχαν φυσιολογικό κύκλο (n=7, oμάδα 1, n=6 ομάδα 2) και οι 8 ήταν μετεμμηνοπαυσιακές γυναίκες (ομάδα 3). Οι γυναίκες της ομάδας 1 έλαβαν αυξημένες δόσεις οιστραδιόλης διαδερμικά από την 3η έως 5η ημέρα του κύκλου. Οι γυναίκες της ομάδας 2 υποβλήθηκαν σε ολική υστερεκτομία μετά των εξαρτημάτων την 3η ημέρα του κύκλου. Οι γυναίκες της ομάδας 3 έλαβαν από του στόματος αυξημένες δόσεις Ε2 για 15 ημέρες. Η ακυλιωμένη γκρελίνη, η αντιπονεκτίνη, η ρεσιστίνη και η Ε2 μετρήθηκαν σε όλα τα δείγματα αίματος. Αποτελέσματα: Στην ομάδα 1, τα επίπεδα της γκρελίνης του πλάσματος και της αντιπονεκτίνης και της ρεσιστίνης στον ορό δεν έδειξαν καμία αλλαγή καθ’όλη την εβδομάδα μετά την 3η ημέρα του κύκλου. Στην ομάδα 2, τα επίπεδα της γκρελίνης, της αντιπονεκτίνης και της ρεσιστίνης ήταν παρόμοια πριν και μετά την επέμβαση και παρέμειναν σταθερά κατά την πρώτη μετεγχειρητική εβδομάδα. Στην ομάδα 3, καμία σημαντική αλλαγή στα επίπεδα της…

Subjects/Keywords: Γκρελίνη; Ρεζιστίνη; Αδιπονεκτίνη; Οιστραδιόλη; Ghrelin; Adiponectin; Resistin; Estradiol

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Χαλβατζάς, . �. (2009). Ο ρόλος των οιστρογόνων στην έκκριση της ghrelin, adiponecting και resistin σε γυναίκες. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/18180

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Χαλβατζάς, Νεκτάριος. “Ο ρόλος των οιστρογόνων στην έκκριση της ghrelin, adiponecting και resistin σε γυναίκες.” 2009. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed August 21, 2019. http://hdl.handle.net/10442/hedi/18180.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Χαλβατζάς, Νεκτάριος. “Ο ρόλος των οιστρογόνων στην έκκριση της ghrelin, adiponecting και resistin σε γυναίκες.” 2009. Web. 21 Aug 2019.

Vancouver:

Χαλβατζάς �. Ο ρόλος των οιστρογόνων στην έκκριση της ghrelin, adiponecting και resistin σε γυναίκες. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2009. [cited 2019 Aug 21]. Available from: http://hdl.handle.net/10442/hedi/18180.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Χαλβατζάς �. Ο ρόλος των οιστρογόνων στην έκκριση της ghrelin, adiponecting και resistin σε γυναίκες. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2009. Available from: http://hdl.handle.net/10442/hedi/18180

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

24. Rajković, Nataša V., 1969-. Analiza povezanosti adipocitokina, gojaznosti i ranih markera ateroskleroze kod pacijenata sa tipom 2 dijabetesa.

Degree: Medicinski fakultet, 2015, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:9705/bdef:Content/get

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medicina - endokrinologija / medical science - endocrinology

Adipocitokini su osnovni molekuli preko kojih masno tkivo ostvaruje efekte na druga tkiva. Rezultati studija ukazuju da… (more)

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medicina - endokrinologija / medical science - endocrinology

Adipocitokini su osnovni molekuli preko kojih masno tkivo ostvaruje efekte na druga tkiva. Rezultati studija ukazuju da je nivo adiponektina snižen, a nivo leptina i rezistina povišen kod gojaznih osoba i kod pacijenata sa tipom 2 dijabetesa (T2D), mada postoje i suprotni nalazi. Takođe, adipocitokini imaju značajnu ulogu u razvoju oboljenja koja su povezana sa gojaznošću a pre svega u razvoju ateroskleroze. Adipocitokini svoje efekte na krvne sudove ostvaruju smanjujući aktivnost sintaze azot oksida (NOS) i snižavajući nivo azot oksida (NO). NO se u organizmu brzo menja u svoje stabilne oksidovane metabolite, merenjem nivoa ovih produkata u plazmi može se jasno odrediti stanje endotelne funkcije. Literaturni podaci ukazuju da su NO i NOS dobri markeri ateroskleroze. U brojnim studijama je pokazano da je nivo oksidovanog LDL-a (oxLDL) povišen kod pacijenata sa T2D a posebno kod onih sa makrovaskularnim komplikacijama, pa je i on dobar parametar smanjene endotelne funkcije. Povezanost izmenjenih adipocitokina sa ranim markerima ateroskleroze kod pacijenata sa T2D nije razjašnjena, kao ni uticaj gojaznosti na ovu povezanost. U tom smislu cilj ovog istraživanja je bio da se prouče efekti adipocitokina, a pre svega njihova povezanost sa ranim markerima ateroskleroze. U našem ispitivanju u cilju proučavanja povezanosti adipocitokina i markera ateroskleroze, analizirali smo najpre povezanost adipocitokina sa standardnim faktorima rizika za razvoj ateroskleroze. Proučavali smo značaj i ulogu insulinske rezistencije, hronične inflamacije, lipidnih parametara i izmenjene fibrinolize u razvoju ateroskleroze kao i povezanost ovih metaboličkih faktora rizika za aterosklerozu sa adipocitokinima kod pacijenata sa T2D. Posebno je proučen efekat gojaznosti na povezanost adipocitokina i markera ateroskleroze. U malom broju studija je analizirana povezanost postprandijalnih promena adipocitokina sa endotelnom disfunkcijom. Rezultati iz literature na ovu temu su vrlo oskudni i za opštu populaciju a posebno je retko ispitivana ova povezanosti kod pacijenata sa T2D. O efektima gojaznosti na ovu povezanost kod pacijenata sa T2D i nema rezultata. U tom smilsu cilj ovog istraživanja je bio i da se analizira povezanost postprandijalnih promena adiponektina sa ranim markerima ateroskleroze kod pacijenata sa T2D kao i uticaj gojaznosti na ovu povezanost...

Advisors/Committee Members: Zamaklar, Miroslava, 1946-.

Subjects/Keywords: adipocytokines; type 2 diabetes; obesity; atherosclerosis; markers of atherosclerosis; postprandial adiponectin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rajković, Nataša V., 1. (2015). Analiza povezanosti adipocitokina, gojaznosti i ranih markera ateroskleroze kod pacijenata sa tipom 2 dijabetesa. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:9705/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Rajković, Nataša V., 1969-. “Analiza povezanosti adipocitokina, gojaznosti i ranih markera ateroskleroze kod pacijenata sa tipom 2 dijabetesa.” 2015. Thesis, Univerzitet u Beogradu. Accessed August 21, 2019. https://fedorabg.bg.ac.rs/fedora/get/o:9705/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Rajković, Nataša V., 1969-. “Analiza povezanosti adipocitokina, gojaznosti i ranih markera ateroskleroze kod pacijenata sa tipom 2 dijabetesa.” 2015. Web. 21 Aug 2019.

Vancouver:

Rajković, Nataša V. 1. Analiza povezanosti adipocitokina, gojaznosti i ranih markera ateroskleroze kod pacijenata sa tipom 2 dijabetesa. [Internet] [Thesis]. Univerzitet u Beogradu; 2015. [cited 2019 Aug 21]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:9705/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Rajković, Nataša V. 1. Analiza povezanosti adipocitokina, gojaznosti i ranih markera ateroskleroze kod pacijenata sa tipom 2 dijabetesa. [Thesis]. Univerzitet u Beogradu; 2015. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:9705/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

25. Sopić, Miron D., 1982-. Određivanje genske ekspresije adiponektinskih receptora AdipoR1 i AdipoR2 i nivoa adiponektina u krvi kod pacijenata sa koronarnom bolešću i pacijenata sa hroničnom bubrežnom insuficijencijom.

Degree: Farmaceutski fakultet, 2016, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:11847/bdef:Content/get

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Medicinska biohemija / Medical biochemistry

Razvoj procedura za dijagnozu kardiovaskularnih bolesti (KVB) kao i uvođenje lekova iz grupe statina u terapiju pacijenata koji pate od… (more)

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Medicinska biohemija / Medical biochemistry

Razvoj procedura za dijagnozu kardiovaskularnih bolesti (KVB) kao i uvođenje lekova iz grupe statina u terapiju pacijenata koji pate od KVB, krajem dvadesetog veka u stručnoj javnosti doveo je do optimističkih procena da će se visoka učestalost mortaliteta uzrokovan komplikacijama KVB značajno umanjiti. Međutim, poslednji podaci Svetske Zdravstvene Organizacije (SZO) svedoče da su bolesti srca i krvnih sudova i dalje vodeći uzrok smrtnosti u srednje i visoko razvijenim zemljama. Navedeni poražavajući podaci ukazuju na potrebu u ispitivanja novih markera koji bi doprineli boljem razumevanju nastanka i razvoja KVB kao i ranom otkrivanju, efikasnijoj terapiji i pouzdanijoj prognozi ishoda bolesti. KVB se često javljaju kao posledica metaboličkih promena koje se dešavaju u sklopu neke druge bolesti. Jedno od takvih stanja je hronična bubrežna insuficijencija (HBI) koja je praćena kompleksnim metaboličkim promenama koji omogućavaju progresivan tok ateroskleroze, pa su pacijenti sa HBI svrstani u grupu sa najvećim rizikom za razvoj KVB. Gojaznost je jedan od tradicionalnih faktora rizika za razvoj KVB. Masno tkivo predstavlja vrlo moćan sekretorni organ koji oslobađa veliki broj molekula sa endokrinim potencijalom utičući tako na različite fiziološke procese. Prekomerna akumulacija masnog tkiva praćena je promenom u funkciji adipocita koji stvarajući proinflamatornu sredinu olakšavaju razvoj ateroskleroze koja leži u osnovi svih KVB. Adiponektin je jedan od najznačajnijih molekula koje oslobađaju adipociti i za razliku od većine drugih pokazuje antiinflamatorno, antiapoptotsko, antiaterosklerotsko i kardioproktektivno dejstvo. Navedeni efekti ostvaruju se aktivacijom adiponektinskih receptora, označenih kao AdipoR1 i AdipoR2. Uprkos njegovim zaštitnim efektima utvrđeno je da su povišene vrednosti adiponektina u koronarnoj srčanoj bolesti (KSB) i HBI povezane sa povećanim rizikom od smrtnosti. Smatra se da bi jedan od mogućih uzroka ovog paradoksa mogao biti poremećaj na nivou ose ligand/receptor koji dovodi do kompenzatornog porasta koncentracije adiponektina. Cilj našeg istraživanja je bio da se ispitaju koncentracije cirkulišućeg adiponektina i nivoi genske ekspresije adiponektinskih receptora AdipoR1 i AdipoR2 u mononuklearnim ćelijama periferne krvi u grupi zdravih ispitanika, pacijenata sa KSB i pacijenata sa HBI na hemodijalizi...

Advisors/Committee Members: Jelić-Ivanović, Zorana, 1951-.

Subjects/Keywords: adiponectin; AdipoR1; AdipoR2; gene expression; coronary artery disease; chronic kidney disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sopić, Miron D., 1. (2016). Određivanje genske ekspresije adiponektinskih receptora AdipoR1 i AdipoR2 i nivoa adiponektina u krvi kod pacijenata sa koronarnom bolešću i pacijenata sa hroničnom bubrežnom insuficijencijom. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:11847/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sopić, Miron D., 1982-. “Određivanje genske ekspresije adiponektinskih receptora AdipoR1 i AdipoR2 i nivoa adiponektina u krvi kod pacijenata sa koronarnom bolešću i pacijenata sa hroničnom bubrežnom insuficijencijom.” 2016. Thesis, Univerzitet u Beogradu. Accessed August 21, 2019. https://fedorabg.bg.ac.rs/fedora/get/o:11847/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sopić, Miron D., 1982-. “Određivanje genske ekspresije adiponektinskih receptora AdipoR1 i AdipoR2 i nivoa adiponektina u krvi kod pacijenata sa koronarnom bolešću i pacijenata sa hroničnom bubrežnom insuficijencijom.” 2016. Web. 21 Aug 2019.

Vancouver:

Sopić, Miron D. 1. Određivanje genske ekspresije adiponektinskih receptora AdipoR1 i AdipoR2 i nivoa adiponektina u krvi kod pacijenata sa koronarnom bolešću i pacijenata sa hroničnom bubrežnom insuficijencijom. [Internet] [Thesis]. Univerzitet u Beogradu; 2016. [cited 2019 Aug 21]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:11847/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sopić, Miron D. 1. Određivanje genske ekspresije adiponektinskih receptora AdipoR1 i AdipoR2 i nivoa adiponektina u krvi kod pacijenata sa koronarnom bolešću i pacijenata sa hroničnom bubrežnom insuficijencijom. [Thesis]. Univerzitet u Beogradu; 2016. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:11847/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Univerzitet u Beogradu

26. Milenković, Svetlana J., 1960-. Povezanost nivoa leptina i adiponektina sa somatskim i metaboličkim parametrima diskordantnih blizanaca.

Degree: Medicinski fakultet, 2017, Univerzitet u Beogradu

URL: https://fedorabg.bg.ac.rs/fedora/get/o:15739/bdef:Content/get

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Medicina - Neonatologija, Intrauterusni zastoj rasta / Medicine - Neonatology, Intrauterine growth restriction

Intrauterusni zastoj rasta (IUZR) je jedan od vodećih uzroka perinatalnog morbiditeta i… (more)

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Medicina - Neonatologija, Intrauterusni zastoj rasta / Medicine - Neonatology, Intrauterine growth restriction

Intrauterusni zastoj rasta (IUZR) je jedan od vodećih uzroka perinatalnog morbiditeta i mortaliteta. Hipertenzija, insulinska rezistencija (IR), dijabetes mellitus tip 2 (T2DM), metabolički sindrom (MS), nizak rast i osteoporoza se dovode u vezu sa IUZR. Skorašnje kliničke i eksperimentalne studije su rasvetlile ulogu koju masno tkivo igra u razvoju insulinske rezistencije i MS kao posledica fetalnog programiranja in utero Cilj ove studije je bio da ispita da li je koncentracija adipokina u krvi pupčanika (P) i u trećem danu (d3) povezana sa usporenim fetalnim rastom i nivoom lipida kod blizanaca sa IUZR. Testirana je povezanost nivoa leptina i adiponektina sa somatskim parametrima i IR na roĎenju i u d3 kod diskordantnih i konkordantnih blizanaca. U studiju je uključeno 36 diskordantnuh (razlika u poroĎajnoj telesnoj masi-TM≥20% računato u odnosu na većeg blizanca) i 42 konkordantna para blizanaca (razlika u TM≤10%), roĎenih≥32 gestacionih nedelja (GN). TM manjeg blizanca je bila ispod 10. percentila (IUZR blizanac) udruženo sa abnormalnim protocima u umbilikalnoj arteriji. Iz venske krvi iz pupčanika kao i iz venske krvi uzete u trećem danu pre jela (d3) su odreĎivani nivoi hormona (leptin, adiponektin, insulin) i bihemijski parametri (glukoza, ukupni holesterol-TC, high density lipoprotein holesterol –HDL C, low density lipoprotein holesterol-LDL C i trigliceridi-TG). Indeksi body mass index-BMI, ponderalni indeks-PI, homeostasis model assesment insulin resistance index-HOMA IR, TG/HDL C i glukoza/insulin (G/I) su izračunati a poslednja tri predstavljaju markere insulinske rezistencije/senzitivnosti. Rezultati: U diskordantnoj grupi nivoi leptina i leptina/TM u krvi iz pupčanika i d3 bili su uporedivi izmeĎu IUZR i blizanaca sa odgovarajućim rastom (appropriate for gestational age-AGA). Kada smo poredili blizance roĎene posle 35 GN koncentracije leptina su bile značajno niže kod IUZR blizanaca u d3 (p=0,011). Nivoi leptina i L/TM u d3 su bili značajno viši kod diskordantnih u odnosu na konkordantne blizance (razlike izmeĎu grupa) (AGA vs. veći, p=0,001 i IUGR vs. manji p=0,004; p=0,001 i p=0,001 respektivno). Koncentracije adiponektina i insulina izmerene na roĎenju i u d3 kao i u podgrupi≥35 GN nisu se statistički značajno razlikovale izmeĎu IUZR i AGA blizanaca. MeĎutim adiponektin/TM je bio viši kod IUZR blizanaca kako u odnosu na AGA blizance tako i u odnosu na manje konkordantne blizance u oba merenja (p=0,002 i p=0,035 respektivno unutar parova i p=0.022 i p=0.002 izmeĎu parova)...

Advisors/Committee Members: Janković, Borisav, 1949-.

Subjects/Keywords: IUGR; leptin; adiponectin; lipids; insulin resistance; fetal programming

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Milenković, Svetlana J., 1. (2017). Povezanost nivoa leptina i adiponektina sa somatskim i metaboličkim parametrima diskordantnih blizanaca. (Thesis). Univerzitet u Beogradu. Retrieved from https://fedorabg.bg.ac.rs/fedora/get/o:15739/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Milenković, Svetlana J., 1960-. “Povezanost nivoa leptina i adiponektina sa somatskim i metaboličkim parametrima diskordantnih blizanaca.” 2017. Thesis, Univerzitet u Beogradu. Accessed August 21, 2019. https://fedorabg.bg.ac.rs/fedora/get/o:15739/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Milenković, Svetlana J., 1960-. “Povezanost nivoa leptina i adiponektina sa somatskim i metaboličkim parametrima diskordantnih blizanaca.” 2017. Web. 21 Aug 2019.

Vancouver:

Milenković, Svetlana J. 1. Povezanost nivoa leptina i adiponektina sa somatskim i metaboličkim parametrima diskordantnih blizanaca. [Internet] [Thesis]. Univerzitet u Beogradu; 2017. [cited 2019 Aug 21]. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:15739/bdef:Content/get.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Milenković, Svetlana J. 1. Povezanost nivoa leptina i adiponektina sa somatskim i metaboličkim parametrima diskordantnih blizanaca. [Thesis]. Univerzitet u Beogradu; 2017. Available from: https://fedorabg.bg.ac.rs/fedora/get/o:15739/bdef:Content/get

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cincinnati

27. Lo, Megan M. Increased Adiponectin is Associated with Left Ventricular Mass Index in Pediatric Chronic Kidney Disease.

Degree: MS, Medicine: Clinical and Translational Research, 2011, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307457705

► Introduction: Chronic kidney disease (CKD) is associated with significantly increased risk of cardiovascular morbidity and mortality. In the general population, adiponectin, a hormone produced… (more)

Subjects/Keywords: Surgery; adiponectin; left ventricular mass index; pediatric; chronic kidney disease

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lo, M. M. (2011). Increased Adiponectin is Associated with Left Ventricular Mass Index in Pediatric Chronic Kidney Disease. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307457705

Chicago Manual of Style (16^th Edition):

Lo, Megan M. “Increased Adiponectin is Associated with Left Ventricular Mass Index in Pediatric Chronic Kidney Disease.” 2011. Masters Thesis, University of Cincinnati. Accessed August 21, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307457705.

MLA Handbook (7^th Edition):

Lo, Megan M. “Increased Adiponectin is Associated with Left Ventricular Mass Index in Pediatric Chronic Kidney Disease.” 2011. Web. 21 Aug 2019.

Vancouver:

Lo MM. Increased Adiponectin is Associated with Left Ventricular Mass Index in Pediatric Chronic Kidney Disease. [Internet] [Masters thesis]. University of Cincinnati; 2011. [cited 2019 Aug 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307457705.

Council of Science Editors:

Lo MM. Increased Adiponectin is Associated with Left Ventricular Mass Index in Pediatric Chronic Kidney Disease. [Masters Thesis]. University of Cincinnati; 2011. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307457705

University of Cincinnati

28. Kaplan, Jennifer Melissa. Immunomodulation During Systemic Inflammation.

Degree: MS, Medicine : Epidemiology (Environmental Health), 2007, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186158205

► Peroxisome proliferator-activated receptor-¿ (PPAR¿) regulates the sepsis-induced inflammatory response. The objective is to determine if PPAR¿ is affected in sepsis. The hypothesis is that PPAR¿… (more)

Subjects/Keywords: inflammation; sepsis; peroxisome proliferator activated receptor gamma; adiponectin

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kaplan, J. M. (2007). Immunomodulation During Systemic Inflammation. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186158205

Chicago Manual of Style (16^th Edition):

Kaplan, Jennifer Melissa. “Immunomodulation During Systemic Inflammation.” 2007. Masters Thesis, University of Cincinnati. Accessed August 21, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186158205.

MLA Handbook (7^th Edition):

Kaplan, Jennifer Melissa. “Immunomodulation During Systemic Inflammation.” 2007. Web. 21 Aug 2019.

Vancouver:

Kaplan JM. Immunomodulation During Systemic Inflammation. [Internet] [Masters thesis]. University of Cincinnati; 2007. [cited 2019 Aug 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186158205.

Council of Science Editors:

Kaplan JM. Immunomodulation During Systemic Inflammation. [Masters Thesis]. University of Cincinnati; 2007. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186158205

University of Cincinnati

29. Summer, Suzanne Spang. The Effects of Diet Composition and Weight Loss on Serum Adiponectin.

Degree: MS, Medicine : Epidemiology (Environmental Health), 2007, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186760448

► Background: Adiponectin is a hormone whose functions contribute to a lowering of disease risk, but adiponectin is typically diminished in obesity. Weight loss can restore… (more)

Subjects/Keywords: Health Sciences, Nutrition; weight loss; diet; adiponectin; obesity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Summer, S. S. (2007). The Effects of Diet Composition and Weight Loss on Serum Adiponectin. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186760448

Chicago Manual of Style (16^th Edition):

Summer, Suzanne Spang. “The Effects of Diet Composition and Weight Loss on Serum Adiponectin.” 2007. Masters Thesis, University of Cincinnati. Accessed August 21, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186760448.

MLA Handbook (7^th Edition):

Summer, Suzanne Spang. “The Effects of Diet Composition and Weight Loss on Serum Adiponectin.” 2007. Web. 21 Aug 2019.

Vancouver:

Summer SS. The Effects of Diet Composition and Weight Loss on Serum Adiponectin. [Internet] [Masters thesis]. University of Cincinnati; 2007. [cited 2019 Aug 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186760448.

Council of Science Editors:

Summer SS. The Effects of Diet Composition and Weight Loss on Serum Adiponectin. [Masters Thesis]. University of Cincinnati; 2007. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1186760448

University of Cincinnati

30. WOO, JESSICA GRAUS. THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS.

Degree: PhD, Medicine : Epidemiology (Environmental Health), 2004, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100808827

► Obesity is increasingly prevalent among adolescents, and the health consequences of obesity are well-documented. Not all obese individuals experience metabolic dysfunction, possibly due to differences… (more)

▼ Obesity is increasingly prevalent among adolescents, and the health consequences of obesity are well-documented. Not all obese individuals experience metabolic dysfunction, possibly due to differences in adipocyte proteins, such as adiponectin. We know little about adiponectin in adolescence, when risks for metabolic disease are established. Therefore, we explored the relationships of demographic, developmental and metabolic traits with adiponectin levels, and associations between adiponectin gene variants, adiponectin levels and metabolic phenotypes in adolescents. We studied 1196 non-Hispanic white (NHW) and African-American (AA) adolescents in the Princeton City School District. In addition to existing data, including height, weight, waist circumference, puberty stage and blood lipids, insulin and glucose, we assayed plasma adiponectin and genotyped nine adiponectin gene variants. Insulin resistance was estimated using HOMA-IR. Adiponectin levels were higher in girls than boys, and higher in NHW than AA adolescents. Lean adolescents (BMI < 85%ile) had higher adiponectin levels than non-lean adolescents (BMI = 85%ile). No sex differences were seen in pre-puberty, but boys’ levels were lower than girls’ in puberty and post-puberty. Adiponectin correlated negatively with body mass index (BMI) z-score, waist circumference, insulin, HOMA-IR, and triglycerides (TG), and positively with high-density lipoprotein (HDL) cholesterol. Correlations were significantly stronger among non-lean vs. lean adolescents for HOMA-IR, TG and HDL cholesterol, and interactions between adiponectin and BMI z-score were significant in models explaining HOMA-IR, HDL and TG. A haplotype in the adiponectin gene promoter (-11391, -10068 and -4521) was significantly associated with higher plasma adiponectin levels in NHW, but only marginally in AA. Surprisingly, this haplotype in NHW was also associated with lower HDL cholesterol and higher TG levels. In AA, haplotypes including variants from -10068 to +712 were independently associated with higher BMI z-score and TG. Sex and race differences in plasma adiponectin are established during puberty. Although adiponectin levels are lower among non-lean adolescents, the association with metabolic phenotypes increases with adiposity. Variants in the adiponectin gene influence adiponectin levels, adiposity and plasma lipid levels in a race-specific manner. Thus, adiponectin has a significant and changing role in adolescents’ metabolic phenotypes, and variants in the adiponectin gene contribute to these phenotypes. Advisors/Committee Members: Daniels, Dr. Stephen (Advisor).

Subjects/Keywords: Adiponectin; Adolescent; Genetic; Obesity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

WOO, J. G. (2004). THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS. (Doctoral Dissertation). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100808827

Chicago Manual of Style (16^th Edition):

WOO, JESSICA GRAUS. “THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS.” 2004. Doctoral Dissertation, University of Cincinnati. Accessed August 21, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100808827.

MLA Handbook (7^th Edition):

WOO, JESSICA GRAUS. “THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS.” 2004. Web. 21 Aug 2019.

Vancouver:

WOO JG. THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS. [Internet] [Doctoral dissertation]. University of Cincinnati; 2004. [cited 2019 Aug 21]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100808827.

Council of Science Editors:

WOO JG. THE EPIDEMIOLOGY OF ADIPONECTIN DURING ADOLESCENCE: DEMOGRAPHIC, DEVELOPMENTAL, METABOLIC AND GENETIC ASSOCIATIONS. [Doctoral Dissertation]. University of Cincinnati; 2004. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100808827

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Open Access Theses and Dissertations