subject:(Adiponectin)

University of Manitoba

1. Murali, Megha. Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin.

Degree: Biochemistry and Medical Genetics, 2016, University of Manitoba

URL: http://hdl.handle.net/1993/31788

► Adiponectin is an abundant hormone secreted by adipocytes that exhibits anti-diabetic, anti-inflammatory and anti-atherogenic properties. However, in obesity, as adipocytes enlarge, adiponectin secretion declines. A… (more)

Subjects/Keywords: Adiponectin

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APA (6^th Edition):

Murali, M. (2016). Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin. (Masters Thesis). University of Manitoba. Retrieved from http://hdl.handle.net/1993/31788

Chicago Manual of Style (16^th Edition):

Murali, Megha. “Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin.” 2016. Masters Thesis, University of Manitoba. Accessed March 01, 2021. http://hdl.handle.net/1993/31788.

MLA Handbook (7^th Edition):

Murali, Megha. “Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin.” 2016. Web. 01 Mar 2021.

Vancouver:

Murali M. Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin. [Internet] [Masters thesis]. University of Manitoba; 2016. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1993/31788.

Council of Science Editors:

Murali M. Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin. [Masters Thesis]. University of Manitoba; 2016. Available from: http://hdl.handle.net/1993/31788

2. An, Si Sandy. GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY.

Degree: 2012, Wake Forest University

URL: http://hdl.handle.net/10339/37273

► Type 2 Diabetes is a complex disease characterized by a combination of environmental, lifestyle, and genetic factors. This study seeks to explore the genetic component… (more)

Subjects/Keywords: adiponectin

…IRASFS 40 2 Linkage analysis of plasma adiponectin on chromosome 3 in IRASFS Hispanic… …families 41 3 Adiponectin levels graphed as a function of the genotype for the common variant… …and 2010 26 2. Summary of family-specific LOD score for plasma adiponectin on chromosome… …DNAs from the IRASFS families 1008 and 2010 38 4. Adiponectin analysis of HMW proportions… …44 5. Contribution of the G45R mutation to variance in serum adiponectin levels 47 6…

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APA (6^th Edition):

An, S. S. (2012). GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY. (Thesis). Wake Forest University. Retrieved from http://hdl.handle.net/10339/37273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

An, Si Sandy. “GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY.” 2012. Thesis, Wake Forest University. Accessed March 01, 2021. http://hdl.handle.net/10339/37273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

An, Si Sandy. “GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY.” 2012. Web. 01 Mar 2021.

Vancouver:

An SS. GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY. [Internet] [Thesis]. Wake Forest University; 2012. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10339/37273.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

An SS. GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY. [Thesis]. Wake Forest University; 2012. Available from: http://hdl.handle.net/10339/37273

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Florida

3. Crosson, Sean M. Investigating the Role of Adiponectin in Taste Perception.

Degree: PhD, Medical Sciences - Genetics (IDP), 2018, University of Florida

URL: https://ufdc.ufl.edu/UFE0052049

► Adiponectin is a hormone secreted into the circulation by adipocytes that mediates key biological functions including insulin sensitivity, adipocyte development, and fatty acid oxidation. In… (more)

Subjects/Keywords: adiponectin – obesity – taste

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APA (6^th Edition):

Crosson, S. M. (2018). Investigating the Role of Adiponectin in Taste Perception. (Doctoral Dissertation). University of Florida. Retrieved from https://ufdc.ufl.edu/UFE0052049

Chicago Manual of Style (16^th Edition):

Crosson, Sean M. “Investigating the Role of Adiponectin in Taste Perception.” 2018. Doctoral Dissertation, University of Florida. Accessed March 01, 2021. https://ufdc.ufl.edu/UFE0052049.

MLA Handbook (7^th Edition):

Crosson, Sean M. “Investigating the Role of Adiponectin in Taste Perception.” 2018. Web. 01 Mar 2021.

Vancouver:

Crosson SM. Investigating the Role of Adiponectin in Taste Perception. [Internet] [Doctoral dissertation]. University of Florida; 2018. [cited 2021 Mar 01]. Available from: https://ufdc.ufl.edu/UFE0052049.

Council of Science Editors:

Crosson SM. Investigating the Role of Adiponectin in Taste Perception. [Doctoral Dissertation]. University of Florida; 2018. Available from: https://ufdc.ufl.edu/UFE0052049

4. ANAHITA HAMIDI. Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore.

Degree: 2009, National University of Singapore

URL: http://scholarbank.nus.edu.sg/handle/10635/23109

Subjects/Keywords: Adiponectin; High Molecular Adiponectin; Adipsin

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APA (6^th Edition):

HAMIDI, A. (2009). Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore. (Thesis). National University of Singapore. Retrieved from http://scholarbank.nus.edu.sg/handle/10635/23109

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

HAMIDI, ANAHITA. “Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore.” 2009. Thesis, National University of Singapore. Accessed March 01, 2021. http://scholarbank.nus.edu.sg/handle/10635/23109.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

HAMIDI, ANAHITA. “Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore.” 2009. Web. 01 Mar 2021.

Vancouver:

HAMIDI A. Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore. [Internet] [Thesis]. National University of Singapore; 2009. [cited 2021 Mar 01]. Available from: http://scholarbank.nus.edu.sg/handle/10635/23109.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

HAMIDI A. Ethnic differences in adipocytokines in severly obese children and adolescents in Singapore. [Thesis]. National University of Singapore; 2009. Available from: http://scholarbank.nus.edu.sg/handle/10635/23109

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

5. Ritchie, Ian. Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training.

Degree: PhD, Department of Human Health and Nutritional Sciences, 2014, University of Guelph

URL: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8309

► This thesis examined whether rapid shifts in skeletal muscle redox balance that follow a high fat diet impair adiponectin (Ad) stimulated fatty acid (FA) oxidation… (more)

▼ This thesis examined whether rapid shifts in skeletal muscle redox balance that follow a high fat diet impair adiponectin (Ad) stimulated fatty acid (FA) oxidation in skeletal muscle from rats. This thesis also examined the importance of Ad as a regulator of mitochondrial content in skeletal muscle at rest and following exercise training. Lastly, this thesis examined whether Ad is required for the increased insulin response observed following exercise training A high fat diet rapidly impairs the ability of Ad to increase FA oxidation in skeletal muscle, but the underlying mechanisms are unknown. In the first study the capacity of Ad to increase palmitate oxidation in soleus and extensor digitorum longus (EDL) was attenuated with HF feeding. HF feeding decreased total GSH and GSH/2GSSG in soleus, but not EDL. N-acetylcysteine prevented the reductions in GSH and GSH/2GSSG in soleus, but did not preserve Ad response. Therefore our data indicates that Ad resistance is induced in both oxidative and glycolytic skeletal muscle, independently of altered cellular redox state. The second study examined the role of Ad as a regulator of mitochondrial content using Ad knockout (AdKO) mice. There were no differences in mitochondrial protein content in red and white gastrocnemius (RG, WG) between WT and AdKO animals. Acute exercise increased the phosphorylation of AMPK and the mRNA expression of mitochondrial proteins in RG and WG with no differences between genotypes. Finally, 8 weeks of exercise training increased the protein content of mitochondrial markers similarly in muscle from both WT and AdKO mice. We conclude that Ad is not required for the regulation of mitochondrial content at rest or during exercise training. In the third study, 8 weeks of exercise training significantly increased glucose and insulin tolerance in both WT and AdKO mice. There were no differences in glucose tolerance between genotypes but insulin tolerance was improved to a greater extent in AdKO mice. There were no genotype differences in the insulin-stimulated phosphorylation of AKT or AS160 in RG or WG. Our results indicate the presence of Ad is not required for exercise-induced increases in insulin response. Advisors/Committee Members: Dyck, David (advisor).

Subjects/Keywords: high fat diet; exercise muscle; skeletal muscle; cytokine; adipokine; adiponectin; adiponectin resistance; adiponectin deficiency; insulin sensitivity; mitochondria; fat oxidation

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APA (6^th Edition):

Ritchie, I. (2014). Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training. (Doctoral Dissertation). University of Guelph. Retrieved from https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8309

Chicago Manual of Style (16^th Edition):

Ritchie, Ian. “Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training.” 2014. Doctoral Dissertation, University of Guelph. Accessed March 01, 2021. https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8309.

MLA Handbook (7^th Edition):

Ritchie, Ian. “Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training.” 2014. Web. 01 Mar 2021.

Vancouver:

Ritchie I. Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training. [Internet] [Doctoral dissertation]. University of Guelph; 2014. [cited 2021 Mar 01]. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8309.

Council of Science Editors:

Ritchie I. Mechanisms of Adiponectin Resistance and the Consequences of Adiponectin Deficiency in Exercise Training. [Doctoral Dissertation]. University of Guelph; 2014. Available from: https://atrium.lib.uoguelph.ca/xmlui/handle/10214/8309

Linköping University

6. Simonsson, Christian. Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes.

Degree: Division of Biomedical Engineering, 2018, Linköping University

URL: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148552

► There is an ongoing worldwide obesity epidemic. As a consequence, prevalence of obesity- related diseases and conditions are rapidly increasing. One of these related… (more)

▼ There is an ongoing worldwide obesity epidemic. As a consequence, prevalence of obesity- related diseases and conditions are rapidly increasing. One of these related conditions is type 2 diabetes (T2D), which alone caused 1.5 million deaths in 2012. Thus, it is of upmost importance to develop a more complete understanding of these interrelated diseases. At the heart of all these diseases lies the adipose tissue. This tissue is a major endocrine organ, and one of the key secreted cytokines is adiponectin. Adiponectin interplays with the complex insulin signaling network, and adiponectin levels are inversely related with increased adiposity. The presence of these complex dependencies argues for the usage of mathematical modelling. In the work of Brännmark et al, a model of short-term adiponectin release has been validated. However, this model did not include adrenergic signaling, which is the canonical pathway for in situ regulation of adiponectin secretion. To fill this gap, herein, a mechanistic model describing adrenaline-induced short-term adiponectin exocytosis in white adipocytes has been constructed. The newly constructed model is capable of describing experimental data depicting adiponectin release due to adrenergic stimulation as well as data for different mediator combinations. By implementing adrenergic receptor components, the transition to a more physiological model has been initiated. By finding the smallest possible model capable of describing data, one can argue that the model depicts, to some degree, the fundamental mechanisms for short-term adiponectin secretion. Thus, this work has contributed to solidifying the framework of the mechanisms behind short-term adiponectin secretion from white adipocytes. The result of the model work upholds the role of adrenergic signaling as a central regulatory mechanism for adiponectin release. The constructed model could be used as a fundament for creating a model describing adiponectin release under diabetic conditions.

Subjects/Keywords: Systems Biology; Mathematical Modeling; Adiponectin; Adiponectin secretion; White Adipocytes; Adrenaline-induced adiponectin secretion; Medical Engineering; Medicinteknik; Medical Biotechnology; Medicinsk bioteknologi

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APA (6^th Edition):

Simonsson, C. (2018). Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes. (Thesis). Linköping University. Retrieved from http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148552

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Simonsson, Christian. “Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes.” 2018. Thesis, Linköping University. Accessed March 01, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148552.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Simonsson, Christian. “Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes.” 2018. Web. 01 Mar 2021.

Vancouver:

Simonsson C. Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes. [Internet] [Thesis]. Linköping University; 2018. [cited 2021 Mar 01]. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148552.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Simonsson C. Mathematical modeling of adrenaline-induced adiponectin secretion in white adipocytes. [Thesis]. Linköping University; 2018. Available from: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148552

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Cincinnati

7. Minter, Anne C. The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics.

Degree: MS, Allied Health Sciences: Nutrition, 2013, University of Cincinnati

URL: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012

► Adiponectin modulates a range of human physiological processes related to metabolism and inflammation. Human milk is known to contain adiponectin in a wide range of… (more)

▼ Adiponectin modulates a range of human physiological processes related to metabolism and inflammation. Human milk is known to contain adiponectin in a wide range of concentrations. Variation in adiponectin concentration remains poorly understood; thus we sought to determine its maternal anthropometric and metabolic correlates. The morning after an overnight fast, lactating mothers (N=20) provided an aliquot of milk from a complete breast expression, and underwent an oral glucose tolerance test (OGTT) and anthropometric measurement. Fasting serum (total and HMW) adiponectin and human milk adiponectin were determined by ELISA. Insulin and glucose concentrations were determined by standard clinical assays. Correlates of human milk adiponectin were evaluated using Spearman rank-order correlation coefficient (r). Adiponectin concentrations (mean [min-max] ng/mL) were: human milk, 30.7 (6.9-92.49) and serum total, 6489 (1356-20257). Human milk adiponectin and serum total adiponectin were positively correlated (r=0.45, p=0.048). Human milk adiponectin was not correlated with other full-body measures of maternal metabolic status (fasting glucose, fasting insulin, insulin sensitivity, or insulin secretion). Likewise, full-body anthropometrics (weight and BMI) were not correlated with milk adiponectin concentration. Reflective of more localized fat depots, body circumference measures became more strongly correlated with human milk adiponectin concentration with increasing proximity to the breast. Spearman correlations of circumferences with human milk adiponectin concentration were hip (r=-0.32, p=0.164); iliac crest (r=-0.46, p=0.039); waist (r=-0.50, p=0.025); under breast (r=-0.56, p=0.011). Our novel finding that under-breast circumference was the strongest correlate of human milk adiponectin suggests that the localized fat depots of the breast may be an important source of adiponectin in human milk. Further studies of how the specific fat depots of the breast and upper body independently influence the breast macro-environment and the bioactives in human milk are warranted. Advisors/Committee Members: Lee, Seung-Yeon (Committee Chair).

Subjects/Keywords: Nutrition; Hormones in human milk; Human milk adiponectin concentration; Milk adiponectin and maternal anthropometrics; Milk adiponectin and Metabolic measures; Lactation; Breastfeeding

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APA (6^th Edition):

Minter, A. C. (2013). The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics. (Masters Thesis). University of Cincinnati. Retrieved from http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012

Chicago Manual of Style (16^th Edition):

Minter, Anne C. “The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics.” 2013. Masters Thesis, University of Cincinnati. Accessed March 01, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012.

MLA Handbook (7^th Edition):

Minter, Anne C. “The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics.” 2013. Web. 01 Mar 2021.

Vancouver:

Minter AC. The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics. [Internet] [Masters thesis]. University of Cincinnati; 2013. [cited 2021 Mar 01]. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012.

Council of Science Editors:

Minter AC. The relationship between human milk adiponectin, maternal measures of metabolic health and anthropometrics. [Masters Thesis]. University of Cincinnati; 2013. Available from: http://rave.ohiolink.edu/etdc/view?acc_num=ucin1384850012

University of Utah

8. Urban, Brittney Marie. The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese.

Degree: MSin Nutrition, Nutrition, 2013, University of Utah

URL: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3476/rec/2642

► Adipokines, including adiponectin and leptin, are secreted by adipose tissue. With an increase in fat mass, concentrations of adiponectin decrease and leptin increase, altering the… (more)

▼ Adipokines, including adiponectin and leptin, are secreted by adipose tissue. With an increase in fat mass, concentrations of adiponectin decrease and leptin increase, altering the adiponectin/leptin (A/L) ratio. A/L ratio is associated with metabolic dysfunction, as are multiple diet factors including breastfeeding in infancy and breakfast intake. However, it is not known whether these diet factors are related to A/L ratio, and if they will protect against metabolic dysfunction in a population at an increased risk. The purpose of this study was to investigate whether breastfeeding duration in infancy and current breakfast frequency are associated with A/L ratio and metabolic dysfunction in children and adolescents with obesity.The study cohort consisted of obese (body mass index ≥ 95th percentile) children and adolescents (n = 100, 46M). Fasting blood samples were taken to measure high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides, insulin, glucose, adiponectin, and leptin levels. Weight, height, and blood pressure were also assessed. Breastfeeding history was obtained through the National Health and Nutrition Examination Survey of 2003-2004, and breakfast frequency was reported through the Gold Medal School Parent Questionnaire administered to parents.Of the 100 participants, 82% were breastfed as infants. Among the breastfed, 66% (n = 54) were breastfed for ≥ 6 months and 62% (n = 54) were breastfed exclusively for ≥ 6 months (4 parents could not recall duration of exclusive breastfeeding). Of thebreakfast responses collected (n = 46), most participants (59%, n = 27) reported consuming breakfast every day. There was no association between these diet factors and A/L ratio or the presence of metabolic dysfunction. Differences in A/L (p = 0.02) and leptin (p = 0.009) were noted between categorical breakfast frequencies when gender was controlled for, and there was a significant difference in BMI between categorical breakfast intakes (p = 0.02). There were no significant relationships in the linear model of breakfast. No association between A/L ratio and metabolic dysfunction was observed. In conclusion, breastfeeding duration and breakfast frequency do not appear to influence A/L ratio or metabolic dysfunction in this population of obese children and adolescents.

Subjects/Keywords: Adiponectin; Breakfast; Breastfeeding; Leptin; Nutrition; Obesity

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APA (6^th Edition):

Urban, B. M. (2013). The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese. (Masters Thesis). University of Utah. Retrieved from http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3476/rec/2642

Chicago Manual of Style (16^th Edition):

Urban, Brittney Marie. “The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese.” 2013. Masters Thesis, University of Utah. Accessed March 01, 2021. http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3476/rec/2642.

MLA Handbook (7^th Edition):

Urban, Brittney Marie. “The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese.” 2013. Web. 01 Mar 2021.

Vancouver:

Urban BM. The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese. [Internet] [Masters thesis]. University of Utah; 2013. [cited 2021 Mar 01]. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3476/rec/2642.

Council of Science Editors:

Urban BM. The relationship between adiponectin to leptin ratio, metabolic dysfunction, and diet in the pediatric obese. [Masters Thesis]. University of Utah; 2013. Available from: http://content.lib.utah.edu/cdm/singleitem/collection/etd3/id/3476/rec/2642

9. Brazaca, Laís Canniatti. Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2.

Degree: Mestrado, Física Aplicada, 2015, University of São Paulo

URL: http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22042015-152351/ ;

►

A obesidade tem aumentado dramaticamente nos últimos anos, tornando-se o maior fator de risco para o desenvolvimento de doenças cardiovasculares, vários tipos de câncer, e… (more)

▼

A obesidade tem aumentado dramaticamente nos últimos anos, tornando-se o maior fator de risco para o desenvolvimento de doenças cardiovasculares, vários tipos de câncer, e também do Diabetes mellitus tipo 2 (DM 2). A associação da obesidade com o desenvolvimento do DM 2 pode ser explicada, em parte, pela secreção alterada pelo tecido adiposo de adipocinas, como a adiponectina, um hormônio com propriedades antiinflamatórias e de sensibilização à insulina. O excesso do tecido adiposo regula negativamente a secreção de adiponectina, o que ocorre de 10 a 20 anos antes da hiperglicemia crônica, fazendo com que este hormônio seja um bom indicador para o diagnóstico preditivo de DM 2. A concentração de adiponectina em plasma é usualmente aferida por ELISA, método não amplamente utilizado devido ao seu alto preço, necessidade de pessoal qualificado e material e, dessa maneira, ainda praticamente inacessível à grande parcela da população. Sendo assim, o desenvolvimento de novas metodologias e de ferramentas de diagnóstico confiáveis e de baixo custo (que possam ser implementados pelo Sistema Único de Saúde SUS) é imprescindível. Aqui, desenvolvemos um biossensor simples e de baixo custo para detecção de adiponectina baseado na espectroscopia de impedância eletroquímica (EIS) ou voltametría cíclica (CV) usando plataformas nanoestruturadas contendo receptores transmembrana de adiponectina (AdipoR1 e AdipoR2) ou anticorpos anti-AdipoQ imobilizados em eletrodos de ouro. Os melhores resultados foram obtidos através do uso dos receptores AdipoR1/R2 em conjunto com CV. Neste caso, os biossensores foram capazes de detectar concentrações de adiponectina tão baixas quanto 7 nmol L-1 com uma faixa linear entre 0,01 a 0,75 mol L-1 de adiponectina, R²=0,992. O dispositivo apresentou ótima seletividade, estabilidade e reprodutibilidade (ca. 1,7% para n=3). Além disso, em amostras de plasma humano, o biossensor obteve resultados muito próximos aos obtidos pelo método pardão ELISA, com desvio de 14%. Esperamos que este estudo propicie maior acessibilidade ao diagnóstico preditivo do DM 2 através de dispositivos mais baratos, rápidos e portáteis e que um maior número indivíduos possam ser alertados e orientados, evitando o desenvolvimento posterior da doença.

Obesity has increased dramatically in the last few years, becoming the biggest risk factor for development of cardiovascular diseases, several types of cancer and also the type 2 diabetes mellitus (DM 2). The association between obesity and DM 2 can be partially explained by the altered secretion of adiponectin hormone by the adipose tissue, which presents anti-inflammatory and insulin sensitizing properties. The excess of adipose tissue regulates negatively adiponectin secretion, which occurs 10 to 20 years before chronic hyperglycemia, making this hormone a great biomarker for predictive DM 2 diagnosis. Adiponectin plasma concentration is usually measured by ELISA, a method not widely used due to its high cost, personal and material demand, being, therefore, not accessible to part…

Advisors/Committee Members: Zucolotto, Valtencir.

Subjects/Keywords: Adiponectin; Adiponectina; Biosensor; Biossensor; Diabetes; Diabetes

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APA (6^th Edition):

Brazaca, L. C. (2015). Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2. (Masters Thesis). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22042015-152351/ ;

Chicago Manual of Style (16^th Edition):

Brazaca, Laís Canniatti. “Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2.” 2015. Masters Thesis, University of São Paulo. Accessed March 01, 2021. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22042015-152351/ ;.

MLA Handbook (7^th Edition):

Brazaca, Laís Canniatti. “Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2.” 2015. Web. 01 Mar 2021.

Vancouver:

Brazaca LC. Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2. [Internet] [Masters thesis]. University of São Paulo; 2015. [cited 2021 Mar 01]. Available from: http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22042015-152351/ ;.

Council of Science Editors:

Brazaca LC. Desenvolvimento de um sistema para o diagnóstico precoce do diabetes mellitus tipo 2. [Masters Thesis]. University of São Paulo; 2015. Available from: http://www.teses.usp.br/teses/disponiveis/76/76132/tde-22042015-152351/ ;

Penn State University

10. Ocon-Grove, Olga M. CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS .

Degree: 2008, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/8936

► Adiponectin is an adipokine hormone which influences several aspects of metabolism, including glucose utilization, insulin sensitivity, lipid synthesis and energy homeostasis by signaling through two… (more)

▼ Adiponectin is an adipokine hormone which influences several aspects of metabolism, including glucose utilization, insulin sensitivity, lipid synthesis and energy homeostasis by signaling through two receptors, AdipoR1 and AdipoR2. A decrease in circulating adiponectin levels, as occurs in obesity in humans, has been associated with the development of insulin resistance, type 2 diabetes and tumor development. The main objectives of the current studies are: (1) To characterize the expression of adiponectin and its receptors in the chicken ovary and testis and (2) To explore their potential role in chicken ovarian tumorigenesis. RT-PCR analyses of RNA isolated from chicken follicular granulosa cells (GC) revealed the presence of AdipoR1 and AdipoR2 mRNA, while adiponectin mRNA was not detected; however, all three transcripts were found in homogenates of whole ovary. Using immunohistochemistry adiponectin-immunoreactive (ir) cells were localized to follicular theca cells (TC) but not the GC, while both AdipoR1-ir and AdipoR2-ir cells were present in TC and GC. Treatment of sexually immature chicken hens with progesterone (P4) decreased ovarian adiponectin mRNA concentration, while estradiol (E2) or P4/E2 treatment increased adiponectin mRNA expression. Estradiol treatment increased ovarian AdipoR1 mRNA quantity, while AdipoR2 mRNA quantity was not affected by any treatment. Quantitative real-time PCR (qPCR) analysis revealed T-cadherin, a putative receptor for high molecular weight adiponectin, and AdipoR1 mRNA were down-regulated in chicken ovarian tumors, while neither ovarian adiponectin nor T-cadherin protein quantities were altered by the presence of ovarian tumors, according to Western blot analysis. Using qPCR, testicular AdipoR1 and AdipoR2 mRNA abundance were 8.3- and 9-fold higher in adult chickens compared to prepubertal chickens, respectively. Adiponectin-ir and AdipoR1-ir cells were detected in testicular peritubular and Leydig cells, while AdipoR2-ir cells were localized in the seminiferous tubule adluminal and luminal compartments and interstitial cells. In particular, Sertoli cell syncytia, round and elongating spermatids, spermatozoa and Leydig cells exhibited strong AdipoR2-immunoreactivity. Collectively, these findings demonstrate that adiponectin and its receptors are present and regulated in cell-specific manner and maybe involved in chicken reproduction. Future studies should focus on altering adiponectin signaling for improving reproductive efficiency in chickens as well as gaining a better understanding of the role adiponectin and its receptors have in reproductive functions. Advisors/Committee Members: Ramesh Ramachandran, Dissertation Advisor/Co-Advisor, Ramesh Ramachandran, Committee Chair/Co-Chair, Daniel R Hagen, Committee Member, Gary Joseph Killian, Committee Member, Troy Ott, Committee Member, Robert Glenn Elkin, Committee Member.

Subjects/Keywords: Ovary; Adiponectin; Testis

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ocon-Grove, O. M. (2008). CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS . (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/8936

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ocon-Grove, Olga M. “CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS .” 2008. Thesis, Penn State University. Accessed March 01, 2021. https://submit-etda.libraries.psu.edu/catalog/8936.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ocon-Grove, Olga M. “CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS .” 2008. Web. 01 Mar 2021.

Vancouver:

Ocon-Grove OM. CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS . [Internet] [Thesis]. Penn State University; 2008. [cited 2021 Mar 01]. Available from: https://submit-etda.libraries.psu.edu/catalog/8936.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ocon-Grove OM. CHARACTERIZATION OF ADIPONECTIN AND ITS RECEPTORS IN THE CHICKEN OVARY AND TESTIS AND THEIR POTENTIAL ROLE IN CHICKEN OVARIAN TUMORIGENESIS . [Thesis]. Penn State University; 2008. Available from: https://submit-etda.libraries.psu.edu/catalog/8936

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Penn State University

11. Giossi, Joseph Thomas. Regulation of Seasonal Changes in Gene Expression via Adiponectin Signaling in a Migratory Bird Species.

Degree: 2017, Penn State University

URL: https://submit-etda.libraries.psu.edu/catalog/13768jtg203

► Prior to migration, birds undergo a period hyperphagia, which serves to increase fat stores for energy-intensive flights. During migration, birds switch from a diurnal to… (more)

Subjects/Keywords: clock; adiponectin; biological clock; sparrow; migration

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APA (6^th Edition):

Giossi, J. T. (2017). Regulation of Seasonal Changes in Gene Expression via Adiponectin Signaling in a Migratory Bird Species. (Thesis). Penn State University. Retrieved from https://submit-etda.libraries.psu.edu/catalog/13768jtg203

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Giossi, Joseph Thomas. “Regulation of Seasonal Changes in Gene Expression via Adiponectin Signaling in a Migratory Bird Species.” 2017. Thesis, Penn State University. Accessed March 01, 2021. https://submit-etda.libraries.psu.edu/catalog/13768jtg203.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Giossi, Joseph Thomas. “Regulation of Seasonal Changes in Gene Expression via Adiponectin Signaling in a Migratory Bird Species.” 2017. Web. 01 Mar 2021.

Vancouver:

Giossi JT. Regulation of Seasonal Changes in Gene Expression via Adiponectin Signaling in a Migratory Bird Species. [Internet] [Thesis]. Penn State University; 2017. [cited 2021 Mar 01]. Available from: https://submit-etda.libraries.psu.edu/catalog/13768jtg203.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Giossi JT. Regulation of Seasonal Changes in Gene Expression via Adiponectin Signaling in a Migratory Bird Species. [Thesis]. Penn State University; 2017. Available from: https://submit-etda.libraries.psu.edu/catalog/13768jtg203

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Addis Ababa University

12. SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE, STRUCTURES. The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human .

Degree: 2012, Addis Ababa University

URL: http://etd.aau.edu.et/dspace/handle/123456789/2882

► Background: The association of obesity with development of type 2 diabetes may be partly mediated by altered secretion of adipokines by adipose tissue. Greater adiposity… (more)

Subjects/Keywords: adiponectin; adipose tissue; type 2 diabetes

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APA (6^th Edition):

SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE, S. (2012). The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human . (Thesis). Addis Ababa University. Retrieved from http://etd.aau.edu.et/dspace/handle/123456789/2882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE, STRUCTURES. “The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human .” 2012. Thesis, Addis Ababa University. Accessed March 01, 2021. http://etd.aau.edu.et/dspace/handle/123456789/2882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE, STRUCTURES. “The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human .” 2012. Web. 01 Mar 2021.

Vancouver:

SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE S. The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human . [Internet] [Thesis]. Addis Ababa University; 2012. [cited 2021 Mar 01]. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2882.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

SOFTWARE DEVELOPMENT FOR HYDROLOGIC ANALYSIS AND HYDRAULIC DESIGN OF MINOR HIGHWAY DRAINAGE S. The involvement of Adiponectin Type 2 Diabetessystematic review of findings on human . [Thesis]. Addis Ababa University; 2012. Available from: http://etd.aau.edu.et/dspace/handle/123456789/2882

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Toronto

13. Ehsan, Mehroz. Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction.

Degree: 2015, University of Toronto

URL: http://hdl.handle.net/1807/71230

►

Monocyte-derived microparticles (MPs) have been suggested to link cardiovascular risk factors to vascular injury. We hypothesized that adiponectin, an anti-inflammatory and vasculoprotective adipokine, limits the… (more)

Subjects/Keywords: Adiponectin; AMPK; inflammation; Microparticles; microvesicles; 0564

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ehsan, M. (2015). Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction. (Masters Thesis). University of Toronto. Retrieved from http://hdl.handle.net/1807/71230

Chicago Manual of Style (16^th Edition):

Ehsan, Mehroz. “Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction.” 2015. Masters Thesis, University of Toronto. Accessed March 01, 2021. http://hdl.handle.net/1807/71230.

MLA Handbook (7^th Edition):

Ehsan, Mehroz. “Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction.” 2015. Web. 01 Mar 2021.

Vancouver:

Ehsan M. Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction. [Internet] [Masters thesis]. University of Toronto; 2015. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/1807/71230.

Council of Science Editors:

Ehsan M. Role of Adiponectin in Monocytic Microparticle-Induced Endothelial Dysfunction. [Masters Thesis]. University of Toronto; 2015. Available from: http://hdl.handle.net/1807/71230

University of Miami

14. Rossetti, Maria Agustina. The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition.

Degree: PhD, Psychology (Arts and Sciences), 2015, University of Miami

URL: https://scholarlyrepository.miami.edu/oa_dissertations/1491

► Objective: BMI in midlife has been shown to increase the risk of dementia later in life, independent of other cardiovascular comorbidities. However, this association reverses… (more)

▼ Objective: BMI in midlife has been shown to increase the risk of dementia later in life, independent of other cardiovascular comorbidities. However, this association reverses direction later in life (age 60-70 years) such that older individuals with dementia have lower BMIs than those without dementia. Adiponectin, an anti-inflammatory cytokine released by adipose tissue, is negatively correlated with body weight and BMI. Adiponectin exists in low molecular weight (LMW) and high molecular weight (HMW) isoforms. It has been proposed that LMW adiponectin may have central effects. This study examined the association of circulating adiponectin isoforms with BMI, memory performance, and brain morphology (hippocampus and white mater hypointensities), in older individuals with memory complaints. Participants and Methods: Ninety-two participants (Mage=75, SD=9) from the University of Miami Memory Disorders Clinic consented to donation of a blood sample and were included for analyses in the present study. Adiponectin immunoassays for adiponectin isoforms were developed with monoclonal antibodies. Memory was measured with the Logical Memory test from the Uniform Data Set (UDS) of the National Alzheimer’s Coordinating Center. Scores were adjusted for demographic factors. Results: Linear regression analyses revealed that BMI predicted total adiponectin (b=-.06, p<.05) and LMW adiponectin (b=-.03, p<.05). Elevated levels total and LMW adiponectin significantly predicted poor immediate memory performance, but only for women (p<.05). We found no significant association with delayed verbal memory. There were also no significant associations among adiponectin isoforms, hippocampal volume, and white matter hypodensities. Conclusions: This study provides preliminary evidence that LMW may exert central effects and serve as an important biomarker of the aging process and cognition. This investigation also highlights an important gender difference in biomarkers of neurodegenerative disease. Further research in larger samples is needed. Advisors/Committee Members: Phil McCabe, Bonnie Levin, Maria Llabre, Armando Mendez, Neil Schneiderman, Clinton Wright.

Subjects/Keywords: adipose tissue; adiponectin; HMW; LMW; cognition

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Rossetti, M. A. (2015). The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition. (Doctoral Dissertation). University of Miami. Retrieved from https://scholarlyrepository.miami.edu/oa_dissertations/1491

Chicago Manual of Style (16^th Edition):

Rossetti, Maria Agustina. “The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition.” 2015. Doctoral Dissertation, University of Miami. Accessed March 01, 2021. https://scholarlyrepository.miami.edu/oa_dissertations/1491.

MLA Handbook (7^th Edition):

Rossetti, Maria Agustina. “The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition.” 2015. Web. 01 Mar 2021.

Vancouver:

Rossetti MA. The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition. [Internet] [Doctoral dissertation]. University of Miami; 2015. [cited 2021 Mar 01]. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1491.

Council of Science Editors:

Rossetti MA. The Relationship among Adiponectin Isoforms, Brain Morphology, and Cognition. [Doctoral Dissertation]. University of Miami; 2015. Available from: https://scholarlyrepository.miami.edu/oa_dissertations/1491

15. Michalakis, Konstantinos. Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους.

Degree: 2016, University of Crete (UOC); Πανεπιστήμιο Κρήτης

URL: http://hdl.handle.net/10442/hedi/37374

►

AIM: Adiponectin, an adipose tissue derived hormone with insulin-sensitizing effects, has been inversely associated to several hormonally-dependent malignancies. Prostate cancer is associated with low levels… (more)

▼

AIM: Adiponectin, an adipose tissue derived hormone with insulin-sensitizing effects, has been inversely associated to several hormonally-dependent malignancies. Prostate cancer is associated with low levels of adiponectin which have been proposed as an independent risk factor for this malignancy. Aim of the current study was to examine whether hypoadiponectinemia in prostate is associated with to insulin resistance. Experimental design: Plasma samples and covariate data in the context of a case-control study of 300 Greek men were evaluated including 75 prostate cancer patients, 75 patients with benign prostatic hyperplasia (BPH), and 150 age-matched healthy controls. Results: Prostate cancer patients had significantly lower plasma adiponectin levels compared to the other two groups i.e. BPH patients and healthy controls (7.4±5ng/ml versus 11.5±6.4ng/ml and 12.8±8ng/ml, respectively). On the other hand, no statistically significant differences were found between prostate cancer patients and the other two groups for both HOMA-IR and QUICKI (p-value= 0.551). As expected, in all three groups, the levels of adiponectin correlated negatively with HOMA-IR (rho=-0.214, p-value=0.006), QUICKI (rho=0.214, p-value=0.006) and insulin levels (rho=0.942, p-value<0.001). Conclusion: In spite to what would have been expected from the relevant literature, our data suggest that the hypoadiponectinemia in prostatic cancer does not appear to be associated to insulin resistance.

Συμπέρασμα: Παρά τα όρια του σχεδιασμού της μελέτης μας, η πρώτη παγκοσμίως μελέτη στην οποία γίνεται σύγκριση των επιπέδων αδιπονεκτίνης και των παραμέτρων της ινσουλινοαντοχής σε ένα επαρκές δείγμα ασθενών με καρκίνο του προστάτη, σε μια προσπάθεια να γίνει διάκριση μεταξύ της απευθείας per se δράση της αδιπονεκτίνης στον καρκίνο του προστάτη, σε σύγκριση με την καλά μέχρι τώρα μελετηθείσα δράση μέσω οδών ευαισθησίας στην ινσουλίνη. Η επίπτωση της αδιπονεκτίνης σε καρκινικούς ασθενείς έχει ήδη τεκμηριωθεί από την ομάδα μας και άλλες ομάδες. Παρ 'όλα αυτά, αυτή είναι η πρώτη άμεση απόπειρα ποτέ να απομονώσει την αδιπονεκτίνη από την ευαισθησία στην ινσουλίνη και η πρώτη έμμεση απόδειξη ότι η αδιπονεκτίνη μπορεί να ενεργεί per se στην παθογένεση του καρκίνου μέσω μιας από τις ανωτέρω οδούς, αλλά όχι εκείνη της αντίστασης στην ινσουλίνη. Αν περαιτέρω μελέτες σε άλλες κακοήθειες δείχνουν τα ίδια αποτελέσματα, αυτό θα ενισχύσει μια τέτοια συσχέτιση. Εν ολίγοις, δείξαμε ότι υψηλότερες συγκεντρώσεις αντιπονεκτίνης στο πλάσμα που σχετίζονται με μειωμένο κίνδυνο καρκίνου του προστάτη σε αυτόν τον πληθυσμό των Ελλήνων ανδρών και ότι όλες οι συσχετίσεις υπάρχουν ανεξάρτητα από το μονοπάτι της ευαισθησίας στην ινσουλίνη, η οποία μέχρι στιγμής έχει προταθεί να είναι η κύρια συνέπεια της αντιπονεκτίνης στην καρκινογένεση. Αυτά τα αποτελέσματα υποδηλώνουν ότι η αδιπονεκτίνη μπορεί να εμπλέκεται στην ανάπτυξη του καρκίνου του προστάτη per se.

Subjects/Keywords: Αδιπονεκτίνη; Καρκίνος προστάτη; Adiponectin Receptors; Prostate cancer

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Michalakis, K. (2016). Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους. (Thesis). University of Crete (UOC); Πανεπιστήμιο Κρήτης. Retrieved from http://hdl.handle.net/10442/hedi/37374

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Michalakis, Konstantinos. “Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους.” 2016. Thesis, University of Crete (UOC); Πανεπιστήμιο Κρήτης. Accessed March 01, 2021. http://hdl.handle.net/10442/hedi/37374.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Michalakis, Konstantinos. “Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους.” 2016. Web. 01 Mar 2021.

Vancouver:

Michalakis K. Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους. [Internet] [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2016. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10442/hedi/37374.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Michalakis K. Τα επίπεδα της αδιπονεκτίνης ως βιολογικός δείκτης ανοσιακών και μεταβολικών διαταραχών σε όγκους. [Thesis]. University of Crete (UOC); Πανεπιστήμιο Κρήτης; 2016. Available from: http://hdl.handle.net/10442/hedi/37374

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

16. Chronis, Aristeidis. Ο ρόλος του λιπώδους ιστού στην ανάπτυξη νεοπλασματικής νόσου του πεπτικού σωλήνα.

Degree: 2016, University of Patras; Πανεπιστήμιο Πατρών

URL: http://hdl.handle.net/10442/hedi/37891

►

PURPOSE: Adiposity has been thought to be related to colorectal carcinogenesis. The aim of this study was to explore any association between obesity factors and… (more)

▼

PURPOSE: Adiposity has been thought to be related to colorectal carcinogenesis. The aim of this study was to explore any association between obesity factors and the presence of colorectal adenoma, a potential precancerous lesion. PATIENTS AND METHODS: Two hundred and six consecutive patients undergoing colonoscopy without colorectal cancer were enrolled in the study. Anthropometric measures and other adiposity-related laboratory variables including insulin resistance and serum adiponectin levels were recorded and correlated with the presence of adenoma. RESULTS: Colorectal adenoma was detected in 68/206 patients (33%), tubular adenoma(s) in 38 patients, and tubulovillous or villous in 30 patients. Twenty-one patients (10.2%) had at least one proximal polyp. The size of the largest adenoma was ≤10 mm in 40 patients and >10 mm in 28 patients. No statistically significant difference was observed in body mass index, waist circumference, fasting plasma glucose concentration, insulin, homeostatic metabolic assessment, cholesterol, low-density lipoproteins, high-density lipoprotein, or triglycerides between patients with and without adenoma. In addition, there was no difference in plasma adiponectin between patients with adenoma (11.1 ± 6 μg/mL) and controls (10.2 ± 7.8 μg/mL). Furthermore, no significant difference in any parameter was found between patients with advanced adenoma and no advanced adenoma, nor between patients with proximal or distal tumors. CONCLUSION: This study found that the presence of colorectal adenoma is not correlated with any adiposity factor. Moreover, obesity does not appear to be associated with the site or the presence of more advanced lesions.

ΣΚΟΠΟΣ: Η αυξημένη παρουσία λιπώδους ιστού έχει θεωρηθεί ότι σχετίζεται με την ορθοκολική καρκινογένεση. Σκοπός αυτής της μελέτης ήταν να διερευνηθεί οποιαδήποτε σχέση μεταξύ των παραγόντων της παχυσαρκίας και της παρουσίας αδενομάτων του παχέος εντέρου, μιας πιθανής προκαρκινικής αλλοίωσης. ΑΣΘΕΝΕΙΣ ΚΑΙ ΜΕΘΟΔΟΙ: Σε μελέτη συμμετείχαν διακόσιοι έξι ασθενείς που υποβλήθηκαν σε κολονοσκόπηση και που δεν παρουσίαζαν ορθοκολικό καρκίνο. Οι ανθρωπομετρικοί παράγοντες και άλλες εργαστηριακές μεταβλητές που σχετίζονται με τη λιπώδη ισορροπία, συμπεριλαμβανομένης της ανθεκτικότητας στην ινσουλίνη και των επιπέδων αδιπονεκτίνης στον ορό, καταγράφηκαν και συσχετίστηκαν με την παρουσία αδενώματος. ΑΠΟΤΕΛΕΣΜΑΤΑ: Αδενώματα του παχέος εντέρου ανιχνεύθηκαν σε 68/206 ασθενείς (33%), σωληνώδη αδένωμα σε 38 ασθενείς και σε σωληνοθηλώδη σε 30 ασθενείς. Είκοσι ένα ασθενείς (10,2%) είχαν τουλάχιστον ένα εγγύς πολύποδα. Το μέγεθος του μεγαλύτερου αδενώματος ήταν <10 mm σε 40 ασθενείς και> 10 mm σε 28 ασθενείς. Δεν παρατηρήθηκε στατιστικά σημαντική διαφορά στο δείκτη μάζας σώματος, περιφέρεια μέσης, συγκέντρωση γλυκόζης πλάσματος νηστείας, ινσουλίνη, ομοιοστατική μεταβολική αξιολόγηση, χοληστερόλη, λιποπρωτεΐνες χαμηλής πυκνότητας, λιποπρωτεΐνη υψηλής πυκνότητας ή τριγλυκερίδια μεταξύ ασθενών με και χωρίς αδένωμα. Επιπλέον, δεν παρατηρήθηκε διαφορά στην αδιπονεκτίνη…

Subjects/Keywords: Αδιπονεκτίνη; Ορθοκολικά αδενώματα; Adiponectin; Colorectal adenomas

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APA (6^th Edition):

Chronis, A. (2016). Ο ρόλος του λιπώδους ιστού στην ανάπτυξη νεοπλασματικής νόσου του πεπτικού σωλήνα. (Thesis). University of Patras; Πανεπιστήμιο Πατρών. Retrieved from http://hdl.handle.net/10442/hedi/37891

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Chronis, Aristeidis. “Ο ρόλος του λιπώδους ιστού στην ανάπτυξη νεοπλασματικής νόσου του πεπτικού σωλήνα.” 2016. Thesis, University of Patras; Πανεπιστήμιο Πατρών. Accessed March 01, 2021. http://hdl.handle.net/10442/hedi/37891.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Chronis, Aristeidis. “Ο ρόλος του λιπώδους ιστού στην ανάπτυξη νεοπλασματικής νόσου του πεπτικού σωλήνα.” 2016. Web. 01 Mar 2021.

Vancouver:

Chronis A. Ο ρόλος του λιπώδους ιστού στην ανάπτυξη νεοπλασματικής νόσου του πεπτικού σωλήνα. [Internet] [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2016. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10442/hedi/37891.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Chronis A. Ο ρόλος του λιπώδους ιστού στην ανάπτυξη νεοπλασματικής νόσου του πεπτικού σωλήνα. [Thesis]. University of Patras; Πανεπιστήμιο Πατρών; 2016. Available from: http://hdl.handle.net/10442/hedi/37891

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Manchester

17. Pelekanou, Charlotte Elizabeth. The role of Rev-erbalpha in adipose tissue physiology.

Degree: 2019, University of Manchester

URL: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322844

► In mammals, the circadian clock is critical to adapting behaviour and physiology to the recurrent fluctuations which dominate our external environment. In line with this,… (more)

▼ In mammals, the circadian clock is critical to adapting behaviour and physiology to the recurrent fluctuations which dominate our external environment. In line with this, the clock is an important regulator of energy metabolism, and disruption of circadian timing in animals and humans is associated with an increased incidence of metabolic dysfunction, obesity and type 2 diabetes. The nuclear hormone receptor Rev-erb-alpha has been identified as an influential link which couples the molecular clockwork to energy state and orchestrates rhythms in lipid metabolism. Our lab and others have shown that mice lacking Rev-erb-alpha (Rev-erb-alpha-/-) exhibit a pronounced obese phenotype, yet retain insulin sensitivity, and reduced obesity-related inflammation in white adipose tissue (WAT). Here, we use novel global and tissue specific transgenic models and combine in vivo phenotyping with proteomic and transcriptional profiling under normal and obese conditions to define the role of Rev-erb-alpha in adipose tissue function. Our findings demonstrate that contrary to recent reports, the metabolic actions of Rev-erb-alpha cannot be segregated based on its ability to directly bind DNA. Specifically, mice lacking either the DNA binding domain of Rev-erb-alpha (Rev-erb-alphaDBD) or the complete protein are phenotypically similar and exhibit pronounced adiposity under normal chow feeding conditions which is exacerbated in response to high fat diet. Increased adiposity is associated with clear up-regulation of glycolytic and lipogenic processes in the WAT of Rev-erb-alpha-/- and Rev-erb-alphaDBD mice. However, in contrast to expectation, adipose selective deletion of Rev-erb-alpha did not lead to increased adiposity or deregulation of WAT metabolism on normal chow, suggesting that the phenotype of the global targeted mice may be driven by sites outside of WAT. Nevertheless, adipose-targeted mice did show exacerbated response to high fat diet. In addition to the circadian clock, we identify collagen dynamics as a direct target of REV-ERB-alpha in WAT, and suggest that altered extracellular matrix remodelling contributes to the enhanced lipid storage seen. In addition to metabolic consequences of Rev-erb-alpha disruption, we investigate the mechanism behind increased high molecular weight (HMW) adiponectin production in these mice. We identify a number of genes involved in lysyl and prolyl hydroxylation that are differentially regulated under diet-induced obesity (in which HMW adiponectin levels decrease) and in Rev-erb-alpha-/- mice. Specifically, our results implicate the lysyl hydroxylase, Plod2, as being a negative regulator of HMW adiponectin production, which is differentially regulated during obesity and in response to Rev-erb-alpha targeting. Overall, this work delineates the direct and indirect impacts of Rev-erb-alpha in governing WAT metabolism, adiponectin production, and obesity development. Rev-erb-alpha remains an important potential therapeutic target in obesity and metabolic dysfunction, although further research is… Advisors/Committee Members: RAY, DAVID DW, LOUDON, ANDREW ASI, Bechtold, David, Ray, David, Loudon, Andrew.

Subjects/Keywords: Rev-erb; obesity; metabolism; adiponectin; inflammation

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Pelekanou, C. E. (2019). The role of Rev-erbalpha in adipose tissue physiology. (Doctoral Dissertation). University of Manchester. Retrieved from http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322844

Chicago Manual of Style (16^th Edition):

Pelekanou, Charlotte Elizabeth. “The role of Rev-erbalpha in adipose tissue physiology.” 2019. Doctoral Dissertation, University of Manchester. Accessed March 01, 2021. http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322844.

MLA Handbook (7^th Edition):

Pelekanou, Charlotte Elizabeth. “The role of Rev-erbalpha in adipose tissue physiology.” 2019. Web. 01 Mar 2021.

Vancouver:

Pelekanou CE. The role of Rev-erbalpha in adipose tissue physiology. [Internet] [Doctoral dissertation]. University of Manchester; 2019. [cited 2021 Mar 01]. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322844.

Council of Science Editors:

Pelekanou CE. The role of Rev-erbalpha in adipose tissue physiology. [Doctoral Dissertation]. University of Manchester; 2019. Available from: http://www.manchester.ac.uk/escholar/uk-ac-man-scw:322844

York University

18. Prioriello, Michelle. The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance.

Degree: MSc -MS, Biology, 2018, York University

URL: http://hdl.handle.net/10315/34349

► Recent research is aiming to elucidate the molecular mechanisms of metabolic syndrome-associated diseases. This study investigates iron overload-induced adiponectin resistance in cardiovascular disease and diabetes.… (more)

Subjects/Keywords: Physiology; Iron overload; Adiponectin; Adiponectin resistance; Iron; Heart; Muscle; Adiponectin signalling; Adiponectin regulation; Mechanism; FOXO1 transcription factor; FOXO1; Diabetes; Heart disease; Heart failure; Cardiac dysfunction; Glucose metabolism

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Prioriello, M. (2018). The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance. (Masters Thesis). York University. Retrieved from http://hdl.handle.net/10315/34349

Chicago Manual of Style (16^th Edition):

Prioriello, Michelle. “The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance.” 2018. Masters Thesis, York University. Accessed March 01, 2021. http://hdl.handle.net/10315/34349.

MLA Handbook (7^th Edition):

Prioriello, Michelle. “The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance.” 2018. Web. 01 Mar 2021.

Vancouver:

Prioriello M. The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance. [Internet] [Masters thesis]. York University; 2018. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10315/34349.

Council of Science Editors:

Prioriello M. The Investigation of Mechanisms Underlying Iron Overload Induced Adiponectin Resistance. [Masters Thesis]. York University; 2018. Available from: http://hdl.handle.net/10315/34349

19. 田邊, 順一. Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用.

Degree: 博士（歯学）, 2016, Osaka Dental University / 大阪歯科大学

URL: http://id.nii.ac.jp/1392/00000063/

►

Adiponectin, an adipocyte-derived biologically active molecule, is a ∼30-kDa polypeptide containing an N-terminal signal sequence, variable domain, collagen-like domain, and C-terminal globular domain. Previously we… (more)

Subjects/Keywords: adiponectin; collagen-like peptide; osteoblast; microarray; adiponectin; collagen-like peptide; osteoblast; microarray

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

田邊, �. (2016). Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用. (Thesis). Osaka Dental University / 大阪歯科大学. Retrieved from http://id.nii.ac.jp/1392/00000063/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

田邊, 順一. “Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用.” 2016. Thesis, Osaka Dental University / 大阪歯科大学. Accessed March 01, 2021. http://id.nii.ac.jp/1392/00000063/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

田邊, 順一. “Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用.” 2016. Web. 01 Mar 2021.

Vancouver:

田邊 �. Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用. [Internet] [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. [cited 2021 Mar 01]. Available from: http://id.nii.ac.jp/1392/00000063/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

田邊 �. Acceleratory Effect of Novel Synthesized Collagen-like Peptide from Adiponectin on Osteoblastic Differentiation : アディポネクチンコラーゲン様ペプチドの骨芽細胞分化促進作用. [Thesis]. Osaka Dental University / 大阪歯科大学; 2016. Available from: http://id.nii.ac.jp/1392/00000063/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

20. Gimenez, Rodrigo Pinto, 1966. Expressão proteica da adiponectina, receptores de adiponectina tipos 1 e 2 e da adipocyte fatty acid binding protein no carcinoma invasor, nas suas lesões precursoras e nas lesões benignas da mama = Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions: Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions.

Degree: 2013, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/311116

► Abstract: Introduction: Obesity has been shown to be responsible for a 30 to 50% increase in new breast cancer cases, in particular in the postmenopausal… (more)

▼ Abstract: Introduction: Obesity has been shown to be responsible for a 30 to 50% increase in new breast cancer cases, in particular in the postmenopausal period. The most recent hypothesis that explains this fact places adipocytes and its autocrine, paracrine and endocrine functions at center stage, linking adipokines secreted by adipocytes to obesity and breast cancer. Objective: Article 1- to compare immunohistochemistry expression pattern of adiponectin (APN) and its receptors types 1 and 2 (adipoR1/R2) in invasive carcinoma (IDC), ductal carcinoma in situ (CDIS) and benign breast lesions (BE), correlated with clinical and histological parameters. Article 2- To assess FABP4 protein expression in epithelial and adipose breast tissue in women diagnosed with IDC, DCIS and benign breast lesions. Material and Methods: Paraffin-embedded blocks from 223 women were included. Of the total number of women, 69 had IDC CDI, 73 had CDIS and 81 had biopsies negative for breast cancer. The patients have been treated at CAISM/Unicamp from January 2008 to December 2011 and Tissue Microarray (TMA) slides were constructed. Expression of APN and Adipo R1/R2 was assessed in tumor tissue in cases of IDC and DCIS and in epithelial tissue in benign cases. FABP4 expression was evaluated in tumor tissue, peritumoral fat tissue (PF) and distant fat breast tissue (DF) in cases of IDC and DCIS and in the epithelial tissue and breast fat tissue in benign cases. To assess a possible relationship between marker expression and anthropometric, clinical and histopathological parameters, the chi-square test or Fisher's exact test, Mann-Whitney test, Kruskal-Wallis test and Spearman's correlation were used. Determinations were calculated, considering a value ?=0.05 (p<0.05) as significant. Results: Article 1 - APN was shown to be expressed in 65% of IDC, 48% of DCIS and 12% of BE and AdipoR1 in 98%, 94% and 71%, respectively. All IDC and DCIS cases expressed AdipoR2 versus 81% of BE. In IDC and DCIS, an association between a higher level of APN expression and ER-negative tumors was observed. In DCIS, this association was also observed with PR-negative tumors. Article 2 - FABP4 protein expression was observed in epithelial tissue in 90% of CDI, 40% of DCIS and 28% of BE. Considering PF and DF, FABP4 expression had a higher level in BE than in IDC, a difference that was considered significant. In patients with IDC, FABP4 expression was higher when diagnosis was made in patients aged up to 50 years. In all cases, this marker was moderately to intensely expressed in the peri-epithelial and distant fat tissue. Conclusions: Discrepancies in protein expression of adiponectin and its receptors AdipoR1/R2 observed in different breast diagnoses suggest its participation in the complex etiologic mechanism of these different conditions. Our results indicate that there is a direct correlation between FABP4 protein expression, breast cancer and obesity Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Costa-Gurgel, Maria Salete, 1956- (advisor), Gurgel, Maria Salete Costa, 1956- (advisor), Barros-Mazon, Silvia de, 1956- (coadvisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Tocoginecologia (nameofprogram), Paiva, Lucia Helena Simões da Costa (committee member), Sarian, Luiz Otavio Zanatta (committee member), Uemura, Gilberto (committee member), Cunha, Isabela Werneck da (committee member).

Subjects/Keywords: Neoplasias da mama; Obesidade; Adiponectina; Receptores de adiponectina; FABP; Breast neoplasms; Obesity; Adiponectin; Receptors, adiponectin; Fatty-acid-binding protein

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gimenez, Rodrigo Pinto, 1. (2013). Expressão proteica da adiponectina, receptores de adiponectina tipos 1 e 2 e da adipocyte fatty acid binding protein no carcinoma invasor, nas suas lesões precursoras e nas lesões benignas da mama = Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions: Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/311116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gimenez, Rodrigo Pinto, 1966. “Expressão proteica da adiponectina, receptores de adiponectina tipos 1 e 2 e da adipocyte fatty acid binding protein no carcinoma invasor, nas suas lesões precursoras e nas lesões benignas da mama = Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions: Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions.” 2013. Thesis, Universidade Estadual de Campinas. Accessed March 01, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gimenez, Rodrigo Pinto, 1966. “Expressão proteica da adiponectina, receptores de adiponectina tipos 1 e 2 e da adipocyte fatty acid binding protein no carcinoma invasor, nas suas lesões precursoras e nas lesões benignas da mama = Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions: Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions.” 2013. Web. 01 Mar 2021.

Vancouver:

Gimenez, Rodrigo Pinto 1. Expressão proteica da adiponectina, receptores de adiponectina tipos 1 e 2 e da adipocyte fatty acid binding protein no carcinoma invasor, nas suas lesões precursoras e nas lesões benignas da mama = Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions: Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions. [Internet] [Thesis]. Universidade Estadual de Campinas; 2013. [cited 2021 Mar 01]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/311116.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gimenez, Rodrigo Pinto 1. Expressão proteica da adiponectina, receptores de adiponectina tipos 1 e 2 e da adipocyte fatty acid binding protein no carcinoma invasor, nas suas lesões precursoras e nas lesões benignas da mama = Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions: Protein expression of adiponectin, adiponectin receptors types 1 and 2 and adipocyte fatty acid binding protein in breast cancer, its precursor lesions and benign breast lesions. [Thesis]. Universidade Estadual de Campinas; 2013. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/311116

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Freie Universität Berlin

21. Wilk, Sabrina. Immunmodulatorische Effekte von Adiponektin.

Degree: 2013, Freie Universität Berlin

URL: http://dx.doi.org/10.17169/refubium-9510

► Adiponektin (APN), ein vom Fettgewebe kontinuierlich sekretiertes Adipozytokin zirkuliert in hohen Konzentrationen im Plasma. Neben seinen vielseitigen metabolischen Funktionen, wird APN als ein anti-inflammatorischer Modulator… (more)

▼ Adiponektin (APN), ein vom Fettgewebe kontinuierlich sekretiertes Adipozytokin zirkuliert in hohen Konzentrationen im Plasma. Neben seinen vielseitigen metabolischen Funktionen, wird APN als ein anti-inflammatorischer Modulator beschrieben. Während der Einfluss von APN auf Monozyten, Makrophagen und epitheliale Zellen mehrfach untersucht wurde, existieren nur wenige Daten, die die Wirkung von APN auf Lymphozyten beschreiben. In dieser Arbeit werden die Adiponektin Rezeptor 1 und 2 (AdipoR1 und 2) Expression auf humanen und murinen T Zellen, ihre Regulation während der Antigenaktivierung, sowie die Effekte des APNs auf T Zellen beschrieben. Des Weiteren wird die AdipoRs Expression auf humanen und murinen NK Zellen und deren Subpopulationen gezeigt und die Wirkung von APNs auf die Funktion humaner NK Zellen charakterisiert. Zusätzlich wird in dieser Arbeit der Effekt von APN auf murine NK Zellen in einem in vitro Model dargestellt. Ich zeige, dass lediglich ein geringer Prozentsatz an humanen und murinen T Zellen AdipoRs auf der Oberfläche exponiert, während beide Rezeptoren von der Mehrheit der T Zellen intrazellulär exprimiert wird. Humane AdipoRs ko-lokalisieren in T Zellen gemeinsam mit den Immunmodulatoren CTLA-4 und TIRC7 in Clathrin umhüllten Vesikeln. Die Stimulation von T Zellen mit Antigenen resultiert in einer Oberflächenexpression beider Rezeptoren auf humanen und murinen T Zellen. Die AdipoRs Oberlächenexposition beschränkt sich hauptsächlich auf antigenaktivierte T Zellen, welche durch die Expression von CD137 und durch Tetramerfärbungen charakterisiert wurden, und mit CTLA-4 koexprimiert werden. APN verringert die antigeninduzierte T Zell Expansion indem die Apoptose von CD137+ T Zellen verstärkt und deren Proliferation inhibiert. Damit einhergehend weisen APN defiziente [(knockout)-KO] Mäuse nach Coxsakie Virus B3 (CVB3) Infektion erhöhte Frequenzen von CD137+ T Zellen auf. Zusätzlich verringert APN die antigenstimulierte Zytokinsekretion von humanen T Zellen. Im Gegensatz, exprimieren nahezu alle humanen CD56dim NK Zellen beide APN Rezeptoren auf ihrer Oberfläche, während den meisten CD56bright NK Zellen die Oberflächenrezeptoren fehlen. Demgegenüber exprimiert nur eine kleine Subpopulation muriner, reifer NK Zellen beide Rezeptoren auf ihrer Oberfläche. Die meisten murinen NK Zellen speichern die AdipoRs intrazellulär und exponieren diese nach CVB3 Infektion an der Oberfläche. APN beeinflusst nicht die Zytotoxizität, inhibiert jedoch die Toll-like Rezeptor (TLR) Ligand (TLR-L) stimulierte IFNγ Sekretion humaner NK Zellen. APN-KO Mäuse weisen erhöhte NK Zell Frequenzen auf, wobei ihre zytotoxische Degranulation erniedrigt ist. Übereinstimmend mit verringerten CD11bhigh CD27high und CD94high Effektor NK Zellen, ist die NKG2D Expression in APN-KO Mäusen vermindert. Die CVB3 Infektion führt zur Wiederherstellung der NK Zell Funktionen, einschließlich der Zytotoxizität und IFNγ Produktion. Insgesamt beschreiben diese Daten APN als einen anti-inflammatorischen, negativen T und NK Zell Regulator. Die Analyse… Advisors/Committee Members: w (gender), Prof. Dr. Rupert Mutzel (firstReferee), Prof. Dr. Carmen Scheibenbogen (furtherReferee).

Subjects/Keywords: adiponectin; Adiponectin receptors (AdipoRs); Immunomodulation; T cells; NK cells; 500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wilk, S. (2013). Immunmodulatorische Effekte von Adiponektin. (Thesis). Freie Universität Berlin. Retrieved from http://dx.doi.org/10.17169/refubium-9510

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wilk, Sabrina. “Immunmodulatorische Effekte von Adiponektin.” 2013. Thesis, Freie Universität Berlin. Accessed March 01, 2021. http://dx.doi.org/10.17169/refubium-9510.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wilk, Sabrina. “Immunmodulatorische Effekte von Adiponektin.” 2013. Web. 01 Mar 2021.

Vancouver:

Wilk S. Immunmodulatorische Effekte von Adiponektin. [Internet] [Thesis]. Freie Universität Berlin; 2013. [cited 2021 Mar 01]. Available from: http://dx.doi.org/10.17169/refubium-9510.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wilk S. Immunmodulatorische Effekte von Adiponektin. [Thesis]. Freie Universität Berlin; 2013. Available from: http://dx.doi.org/10.17169/refubium-9510

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Kyoto University

22. Choi, Jungmi. β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice .

Degree: 2020, Kyoto University

URL: http://hdl.handle.net/2433/253222

Subjects/Keywords: Adiponectin; Adiponectin receptor 1; Diabetes; Akita mice

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Choi, J. (2020). β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice . (Thesis). Kyoto University. Retrieved from http://hdl.handle.net/2433/253222

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Choi, Jungmi. “β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice .” 2020. Thesis, Kyoto University. Accessed March 01, 2021. http://hdl.handle.net/2433/253222.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Choi, Jungmi. “β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice .” 2020. Web. 01 Mar 2021.

Vancouver:

Choi J. β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice . [Internet] [Thesis]. Kyoto University; 2020. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/2433/253222.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Choi J. β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice . [Thesis]. Kyoto University; 2020. Available from: http://hdl.handle.net/2433/253222

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Tampere University

23. Koskinen-Kolasa, Anna. Adipocytokines in Osteoarthritis .

Degree: 2018, Tampere University

URL: https://trepo.tuni.fi/handle/10024/102695

► Nivelrikko on maailman yleisin nivelsairaus. Toistaiseksi siihen ei ole onnistuttu kehittämään parantavaa tai taudin etenemistä hidastavaa hoitoa. Nivelrikon riskitekijät tunnetaan hyvin, mutta niiden yhteys tautiprosessiin… (more)

▼ Nivelrikko on maailman yleisin nivelsairaus. Toistaiseksi siihen ei ole onnistuttu kehittämään parantavaa tai taudin etenemistä hidastavaa hoitoa. Nivelrikon riskitekijät tunnetaan hyvin, mutta niiden yhteys tautiprosessiin on monelta osin tuntematon. Nivelrikkoa hidastavien lääkeaineiden kehityksen kannalta on tärkeää saada uutta tietoa nivelrikkoon johtavista molekyylitason mekanismeista. Lihavuus on merkittävä nivelrikon riskitekijä. Lihavuuden yhteyttä nivelrikkoon selittää osin kantaville nivelille kohdistuva ylimääräinen kuorma. Lihavuus on kuitenkin myös sorminivelrikon riskitekijä. Tämä viittaa siihen, että on olemassa jokin lihavuuteen liittyvä metabolinen tekijä (tai tekijöitä), joka välittää lihavuuden vaikutuksen niveliin systeemisesti, ts. verenkierron, ja edelleen nivelnesteen kautta. Adiposytokiinit, eli adipokiinit, ovat rasvakudoksen erittämiä hormoneja. Alun perin adipokiinien havaittiin säätelevän ruokahalua ja toimivan kehon energiatasapainoa säätelevinä molekyyleinä. Sittemmin adipokiinien on huomattu säätelevän myös muita kehon toimintoja, kuten tulehdusreaktiota. Adipokiineja on löydetty myös nivelrikkonivelistä, ja niiden on hypotisoitu osallistuvan nivelsairauksien patogeneesiin. Tämän tutkimuksen tarkoituksena oli tutkia kolmen adipokiinin, adiponektiinin, leptiinin ja resistiinin merkitystä nivelrikon patogeneesissa, ja niiden roolia lihavuutta ja nivelrikkoa yhdistävinä tekijöinä. Tavoitteena oli näin tuottaa uutta tietoa mahdollisista uusista nivelrikon lääkehoidon kohteista. Tutkimusta varten kerättiin poikkileikkausaineisto sadalta polven tekonivelleikkauspotilaalta, sisältäen kliiniset tiedot, veri- ja nivelnestenäytteet, sekä rustonäytteet rustoviljelmää varten. Näytteistä analysoitiin adiponektiinin, leptiinin ja resistiinin pitoisuudet, ja verrattiin niitä nivelrikon patogeneesin kannalta tärkeiden tulehduksellisten välittäjäaineiden, mukaan lukien typpioksidin (engl. nitric oxide, NO), interleukiini-6:n (IL-6), ja katabolisten rustoa hajottavien entsyymien, matriksimetalloproteinaasien (MMP), pitoisuuksiin. Aineiston perusteella tutkittiin myös adipokiinien yhteyttä nivelrikon radiologiseen vakavuusasteeseen, nivelrikon biomarkkereihin sekä nivelrikon kliiniseen vaikeusastemittariin (Knee Society Score, KSS). Lisäksi adiponektiinin ja leptiinin vaikutuksia, sekä niitä välittäviä solunsisäisiä signalointireittejä ja säätelymekanismeja tutkittiin nivelrikkorusto- ja rustosoluviljelmissä. Adiponektiini- ja leptiinipitoisuudet verenkierrossa ja nivelnesteessä, ja kaikkien kolmen adipokiinin pitoisuudet rustoviljelmässä olivat suurempia naisilla kuin miehillä. Leptiini korreloi vahvasti painoindeksin (BMI, body mass index) kanssa niin verenkierrosta, kuin myös nivelnesteestä ja rustoviljelmästä mitattuna. Adiponektiinipitoisuus korreloi NO:n, IL-6:n, MMP-1:n, MMP-3:n ja MMP-13:n kanssa nivelnesteessä ja/tai rustoviljelmän elatusnesteessä. Adiponektiini lisäsi näiden tekijöiden tuottoa viljellyssä nivelrikkorustossa ja rustosoluissa. Vaikutusta välitti solunsisäinen…

Subjects/Keywords: adiponektiini ; leptiini ; resistiini ; nivelrikko ; lihavuus ; adiponectin ; leptin ; resistin ; osteoarthritis ; obesity

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Koskinen-Kolasa, A. (2018). Adipocytokines in Osteoarthritis . (Doctoral Dissertation). Tampere University. Retrieved from https://trepo.tuni.fi/handle/10024/102695

Chicago Manual of Style (16^th Edition):

Koskinen-Kolasa, Anna. “Adipocytokines in Osteoarthritis .” 2018. Doctoral Dissertation, Tampere University. Accessed March 01, 2021. https://trepo.tuni.fi/handle/10024/102695.

MLA Handbook (7^th Edition):

Koskinen-Kolasa, Anna. “Adipocytokines in Osteoarthritis .” 2018. Web. 01 Mar 2021.

Vancouver:

Koskinen-Kolasa A. Adipocytokines in Osteoarthritis . [Internet] [Doctoral dissertation]. Tampere University; 2018. [cited 2021 Mar 01]. Available from: https://trepo.tuni.fi/handle/10024/102695.

Council of Science Editors:

Koskinen-Kolasa A. Adipocytokines in Osteoarthritis . [Doctoral Dissertation]. Tampere University; 2018. Available from: https://trepo.tuni.fi/handle/10024/102695

Universidade do Rio Grande do Sul

24. Menna Barreto, Ana Lúcia V. Sintomas vasomotores e associação entre adipocinas séricas (adiponectina e PAI-1), moléculas de adesão (ICAM-1 E VCAM-1) e estado nutricional de mulheres peri e pós-menopáusicas.

Degree: 2013, Universidade do Rio Grande do Sul

URL: http://hdl.handle.net/10183/88430

► Introdução: O climatério é definido como a fase que compreende a transição entre o período reprodutivo e o não reprodutivo da vida da mulher. Durante… (more)

▼ Introdução: O climatério é definido como a fase que compreende a transição entre o período reprodutivo e o não reprodutivo da vida da mulher. Durante esse período e, principalmente, no período pós-menopáusico as mulheres tendem a ganhar mais peso e modificar o padrão de distribuição de gordura corporal. Sabe-se que adipocinas liberadas pelo tecido adiposo, que têm ações diversas como função imunológica, cardiovascular, metabólica e endócrina, podem contribuir para o desenvolvimento de comorbidades, como aterosclerose e diabetes melitus tipo 2. Outras moléculas estão envolvidas nos processos metabólicos, como as moléculas de adesão celular (CAM), que já foram estudadas como preditoras de eventos cardiovasculares. Sabe-se ainda que na mulher pós-menopausa há uma relação inversa entre o exercício praticado regularmente e as principais causas de comorbidades. Objetivos: Analisar os sintomas vasomotores e sua associação com os níveis séricos de adipocinas( ADIPONECTINA E PAI- 1), moléculas de adesão (ICAM-1 e VCAM-1) e a relação com o estado nutricional em um grupo de mulheres peri e pós-menopáusicas atendidas no ambulatório de Climatério do Serviço de Ginecologia do HCPA. Métodos: Estudo transversal com 102 mulheres pré e pósmenopáusicas, com idade entre 40 e 65 anos, atendidas no Ambulatório de Climatério do Serviço de Ginecologia do HCPA. Todas participantes foram avaliadas quanto a massa corporal massa, estatura, circunferência da cintura IMC, circunferência da cintura, determinação de percentual de gordura através da mensuração das dobras cutâneas: triciptal, supra-ilíaca e coxa. Níveis séricos de colesterol total, HDL colesterol, LDL colesterol e triglicerídeos, glicose, adipocinas (ADIPONECTINA E PAI-1), moléculas de adesão (ICAM-1 e VCAM-1) foram investigados. Resultados: A média de idade foi 53,8 ± 5,4 anos, mediana de tempo de menopausa 48 (10-96) meses, e 68 (66,7 %) das mulheres estava na pósmenopausa. A avaliação antropométrica mostrou que 42 (41,2 %) delas tinham sobrepeso segundo Índice de masa corporal (IMC), e 51 (50,0 %) apresentaram risco cardiovascular muito elevado para circunferência de cintura, a média de % de massa gorda era de 33,3 ± 5,3 e 38 (37,25%) delas eram hipertensas. Os valores médios (± DP) dos exames laboratoriais foram: colesterol total de 214,4 (±42,3), glicose 91,9 (± 37,8), adiponectina 22,5 (± 11,8), PAI-1 284,9 (± 134,1), ICAM 1 457,0 (± 210,6) e VCAM 1 202,0 (± 61,3). Em relação aos sintomas, 76 (74,5%) delas tinham fogachos, 45 (44,1 %) depressão leve a moderada segundo escore de Beck, e 79 (77,5 %) tinham insônia conforme escore de Pisttburg (PSQI). Setenta e três das pacientes (71,6 %) foram classificadas como ativas segundo escore de atividade física IPAQ. Não foi observada relação estatisticamente significativa entre os níveis de adipocinas ou moléculas de adesão e fogachos. A adiponectina foi negativamente e inversamente associada com o IMC. Houve uma correlação inversa estatisticamente significativa entre idade e intensidade dos fogachos. Conclusão: As alterações em vários… Advisors/Committee Members: Wender, Maria Celeste Osório.

Subjects/Keywords: Menopause; Menopausa; Fogachos; Hot flashes; Adiponectina; Adiponectin; Antropometria; Anthropometry

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Menna Barreto, A. L. V. (2013). Sintomas vasomotores e associação entre adipocinas séricas (adiponectina e PAI-1), moléculas de adesão (ICAM-1 E VCAM-1) e estado nutricional de mulheres peri e pós-menopáusicas. (Thesis). Universidade do Rio Grande do Sul. Retrieved from http://hdl.handle.net/10183/88430

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Menna Barreto, Ana Lúcia V. “Sintomas vasomotores e associação entre adipocinas séricas (adiponectina e PAI-1), moléculas de adesão (ICAM-1 E VCAM-1) e estado nutricional de mulheres peri e pós-menopáusicas.” 2013. Thesis, Universidade do Rio Grande do Sul. Accessed March 01, 2021. http://hdl.handle.net/10183/88430.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Menna Barreto, Ana Lúcia V. “Sintomas vasomotores e associação entre adipocinas séricas (adiponectina e PAI-1), moléculas de adesão (ICAM-1 E VCAM-1) e estado nutricional de mulheres peri e pós-menopáusicas.” 2013. Web. 01 Mar 2021.

Vancouver:

Menna Barreto ALV. Sintomas vasomotores e associação entre adipocinas séricas (adiponectina e PAI-1), moléculas de adesão (ICAM-1 E VCAM-1) e estado nutricional de mulheres peri e pós-menopáusicas. [Internet] [Thesis]. Universidade do Rio Grande do Sul; 2013. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10183/88430.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Menna Barreto ALV. Sintomas vasomotores e associação entre adipocinas séricas (adiponectina e PAI-1), moléculas de adesão (ICAM-1 E VCAM-1) e estado nutricional de mulheres peri e pós-menopáusicas. [Thesis]. Universidade do Rio Grande do Sul; 2013. Available from: http://hdl.handle.net/10183/88430

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

25. Σούρλας, Δημήτριος. Ghrelin και αναπαραγωγή.

Degree: 2011, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας

URL: http://hdl.handle.net/10442/hedi/25011

► Introduction: Conflicting data have been reported about the role of exogenous and endogenous ovarian steroids on the secretion of ghrelin, resistin, and adiponectin . The… (more)

▼ Introduction: Conflicting data have been reported about the role of exogenous and endogenous ovarian steroids on the secretion of ghrelin, resistin, and adiponectin . The objective of the present study was to investigate changes of ghrelin, resistin, and adiponectin levels in the circulation during a) the normal menstrual cycle and b) in ovarian stimulation with FSH for multiple follicular development. Material & methods: a) Eight healthy normally cycling women were observed during a whole menstrual cycle. Daily blood samples were taken every morning, after overnight fasting, from day 2 of the cycle until the next menstrual period. Plasma acylated and unacylated ghrelin, and serum resistin, adiponectin, FSH, LH, E2, and P levels were measured in all blood samples. b) Twenty healthy normally cycling women, aged 31.2±0.8 years with BMI 24.5±1.9 kg/m2, were stimulated in a single cycle with recombinant FSH in a GnRH agonist short protocol for IVF/ICSI due to male infertility. Luteal phase support with vaginal progesterone was given to all women. Blood samples were taken in the morning, after overnight fasting, on cycle day 2 before the commencement of FSH and GnRH agonist injections, on cycle days 5 and 7 and on the days of HCG injection, oocyte retrieval (OR), embryo transfer (ET, two days after the OR) as well as 7 and 12 days following ET. Plasma total ghrelin and serum adiponectin, resistin, FSH, LH, E2, and progesterone levels were measured in all blood samples. Results: a) In all women serum FSH, LH, E2, and P levels, normalized to the midcycle peak LH value, showed the typical changes of the normal menstrual cycle. Acylated and unacylated ghrelin, resistin, and adiponectin levels did not change significantly during the whole menstrual cycle. b) Plasma total ghrelin was 667.9±44 pg/ml before the stimulation with FSH and remained unchanged during the whole study period. Serum adiponectin levels were 10.3±1.0 μg/ml before the stimulation with FSH, remaining stable during the stimulation period until the day of ET and decreasing significantly on days 7 and 12 (8.6±0.8 μg/ml) post-ET (p<0.001). Serum resistin levels were 3.2±0.3 ng/ml before the FSH administration increasing gradually until the day of ET (4.2±0.2 ng/ml) (p<0.05), remaining unchanged on day 7 post-ET and decreasing significantly on day 12 post-ET (3.6±0.2 ng/ml, p<0.05). Conclusions: The present study shows for the first time that plasma ghrelin and serum resistin and adiponectin levels do not change significantly during the normal menstrual cycle. It is suggested that ovarian steroid dynamics during the cycle have no effect on the secretion of these substances. It is also shown for the first time that plasma ghrelin levels did not change significantly during ovarian stimulation for IVF/ICSI-ET. Serum resistin levels increased during the stimulation period while adiponectin levels remained stable decreasing during the luteal phase. It is suggested that ovarian steroid dynamics in superovulated cycles control differentially resistin and adiponectin…

Subjects/Keywords: Γκρελίνη; Αντιπονεκτίνη; Ρεζιστίνη; Αναπαραγωγή; Ghrelin; Adiponectin; Resistin; Reproduction

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Σούρλας, . �. (2011). Ghrelin και αναπαραγωγή. (Thesis). University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Retrieved from http://hdl.handle.net/10442/hedi/25011

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Σούρλας, Δημήτριος. “Ghrelin και αναπαραγωγή.” 2011. Thesis, University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας. Accessed March 01, 2021. http://hdl.handle.net/10442/hedi/25011.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Σούρλας, Δημήτριος. “Ghrelin και αναπαραγωγή.” 2011. Web. 01 Mar 2021.

Vancouver:

Σούρλας �. Ghrelin και αναπαραγωγή. [Internet] [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2011. [cited 2021 Mar 01]. Available from: http://hdl.handle.net/10442/hedi/25011.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Σούρλας �. Ghrelin και αναπαραγωγή. [Thesis]. University of Thessaly (UTH); Πανεπιστήμιο Θεσσαλίας; 2011. Available from: http://hdl.handle.net/10442/hedi/25011

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universidade Estadual de Campinas

26. Faria, Ana Paula Cabral de, 1986-. Os polimorfismos -11377C/G e +276G/T no gene ADIPOQ estão associados aos níveis de adiponectina na hipertensão arterial resistente = Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension: Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension.

Degree: 2014, Universidade Estadual de Campinas

URL: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312686

► Abstract: Background: Resistant hypertension (RHTN) is a multifactorial and polygenic disease, frequently associated with obesity, and defined as high blood pressure (BP) maintained in spite… (more)

▼ Abstract: Background: Resistant hypertension (RHTN) is a multifactorial and polygenic disease, frequently associated with obesity, and defined as high blood pressure (BP) maintained in spite of concurrent use of three or more antihypertensive drugs of different classes, combined at optimal doses and including a diuretic. Previous studies demonstrated that low plasma adiponectin levels, a hormone produced by the adipose tissue, were associated with RHTN. Indeed, single-nucleotide polymorphisms (SNPs) rs266729 and rs1501299 in adiponectin coding gene ADIPOQ were associated with hypertension and risk of cardiovascular disease. This study evaluated the association between two of the most widely studied SNPs (-11377C/G and +276G/T) and adiponectin plasma levels in RHTN subjects. Design and Methods: This study comprised 109 RH patients genotyped for both polymorphisms by Real-time Polymerase Chain Reaction (PCR) method using fluorescent probes. We conducted a cross-sectional design comparing clinical and laboratorial characteristics of CC homozygous (n=56) vs. G allele carriers (n=53) for -11377C/G and GG homozygous (n=49) vs. T allele carriers (n=60) for +276G/T. Adiponectin levels were measured by enzyme-linked immunoassay. Results: Office and ambulatory BP measurements were similar among genotypes subgroups in both SNPs as well as the markers of target organ damage. Adiponectin levels were significantly higher in CC compared to G-carrier for -11377C/G (CC = 7.0 (4.0-10.2) vs. G allele = 5.5 (2.5-7.9), p=0.04) and lower in GG compared to T-carrier for +276G/T (GG = 5.3 (2.3-7.7) vs. T allele = 7.1 (3.6-10.5), p=0.04). Adjusting for systolic ambulatory BP, body mass index, age, gender, race and presence of type 2 diabetes, multiple linear regression revealed that the minor alleles G (beta coefficient = -0.16, SE = 0.07, p = 0.02) and T (beta coefficient = 0.12, SE = 0.06, p = 0.04) were independent predictors of adiponectin levels. Conclusion: The -1377C/G and +276G/T polymorphisms in ADIPOQ were associated with adiponectin levels in RH subjects Advisors/Committee Members: UNIVERSIDADE ESTADUAL DE CAMPINAS (CRUESP), Moreno Junior, Heitor, 1958- (advisor), Universidade Estadual de Campinas. Faculdade de Ciências Médicas (institution), Programa de Pós-Graduação em Farmacologia (nameofprogram), Gontijo, Jose Antonio Rocha (committee member), Anhê, Gabriel Forato (committee member), Luizon, Marcelo Rizzatti (committee member), Lopes, Heno Ferreira (committee member).

Subjects/Keywords: Hipertensão; Obesidade; Adiponectina; Genética molecular; Hypertension; Obesity; Adiponectin; Molecular genetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Faria, Ana Paula Cabral de, 1. (2014). Os polimorfismos -11377C/G e +276G/T no gene ADIPOQ estão associados aos níveis de adiponectina na hipertensão arterial resistente = Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension: Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension. (Thesis). Universidade Estadual de Campinas. Retrieved from http://repositorio.unicamp.br/jspui/handle/REPOSIP/312686

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Faria, Ana Paula Cabral de, 1986-. “Os polimorfismos -11377C/G e +276G/T no gene ADIPOQ estão associados aos níveis de adiponectina na hipertensão arterial resistente = Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension: Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension.” 2014. Thesis, Universidade Estadual de Campinas. Accessed March 01, 2021. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312686.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Faria, Ana Paula Cabral de, 1986-. “Os polimorfismos -11377C/G e +276G/T no gene ADIPOQ estão associados aos níveis de adiponectina na hipertensão arterial resistente = Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension: Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension.” 2014. Web. 01 Mar 2021.

Vancouver:

Faria, Ana Paula Cabral de 1. Os polimorfismos -11377C/G e +276G/T no gene ADIPOQ estão associados aos níveis de adiponectina na hipertensão arterial resistente = Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension: Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension. [Internet] [Thesis]. Universidade Estadual de Campinas; 2014. [cited 2021 Mar 01]. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312686.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Faria, Ana Paula Cabral de 1. Os polimorfismos -11377C/G e +276G/T no gene ADIPOQ estão associados aos níveis de adiponectina na hipertensão arterial resistente = Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension: Adiponectin polymorphisms -11377G/T and +276G/T are associated with adiponectin levels in resistant hypertension. [Thesis]. Universidade Estadual de Campinas; 2014. Available from: http://repositorio.unicamp.br/jspui/handle/REPOSIP/312686

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Jawaharlal Nehru University

27. Sanal, M G. Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -.

Degree: Medicine, 2008, Jawaharlal Nehru University

URL: http://shodhganga.inflibnet.ac.in/handle/10603/17526

None

References p.131-144 , Appendix iii-xxii

Advisors/Committee Members: Sarin, Shiv Kumar.

Subjects/Keywords: Medicine; Molecular; adiponectin; nonalcoholic; diseases

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Sanal, M. G. (2008). Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -. (Thesis). Jawaharlal Nehru University. Retrieved from http://shodhganga.inflibnet.ac.in/handle/10603/17526

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Sanal, M G. “Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -.” 2008. Thesis, Jawaharlal Nehru University. Accessed March 01, 2021. http://shodhganga.inflibnet.ac.in/handle/10603/17526.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Sanal, M G. “Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -.” 2008. Web. 01 Mar 2021.

Vancouver:

Sanal MG. Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -. [Internet] [Thesis]. Jawaharlal Nehru University; 2008. [cited 2021 Mar 01]. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/17526.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Sanal MG. Molecular biology of adiponectin in nonalcoholic fatty liver diseases; -. [Thesis]. Jawaharlal Nehru University; 2008. Available from: http://shodhganga.inflibnet.ac.in/handle/10603/17526

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Wollongong

28. Neale, Elizabeth Phillipa. Food or nutrients? A comparison of the effectiveness and efficacy of increased fish and long chain omega-3 polyunsaturated fatty acid supplement consumption in the context of metabolic health.

Degree: Doctor of Philosophy, 2012, University of Wollongong

URL: 1111 NUTRITION AND DIETETICS ; https://ro.uow.edu.au/theses/3585

► One of the big challenges facing evidence-based nutrition is the apparent discord between the study of whole foods and of their constituent nutrients. Fish… (more)

▼ One of the big challenges facing evidence-based nutrition is the apparent discord between the study of whole foods and of their constituent nutrients. Fish and long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFA) are a case in point where questions lie as to the relative value of the food versus a key nutrient. Likewise, little research considers the effectiveness of dietary advice, in addition to the efficacy on health outcomes, of consuming whole foods versus nutrients, and numerous methodological challenges exist for exposing both factors. Finally, there is a paucity of biomarkers that reflect health rather than disease. An emerging biomarker of health is adiponectin, which has been associated with both fish and LC n-3 PUFA consumption; however there is little research comparing their effects on adiponectin levels. The central hypothesis of this thesis is that consuming fish may be more beneficial to health than supplements of LC n-3 PUFA, however, behavioural issues may impede the effectiveness of advice targeting habitual fish consumption. In this thesis, methodological issues relating to fish consumption were addressed and adiponectin was considered as a biomarker of health. Data from a 12 month clinical trial involving consumption of fish and LC n-3 PUFA supplements was analysed, and a separate study comparing fish with LC n-3 PUFA supplements was conducted. It was first necessary to ensure methods were available to accurately measure fish and LC n-3 PUFA consumption. Because of the popularity of canned fish products in Australia, a database of the percentage fish in canned products was developed and validated. Dietary data collected over the duration of a 12 month clinical trial was converted to an updated Australian food composition database via a defined strategy to allow for measurement of LC n-3 PUFA intake. Dietary methodology was applied to investigate changes in fish and LC n-3 PUFA consumption over the duration of the 12 month clinical trial and to assess compliance to intake recommendations (effectiveness of dietary advice). Fish consumption was highest at the three month time point of the trial and compliance to intake recommendations was higher for supplements than for fish. To further investigate why these patterns of consumption were seen, a study in the social research domain was conducted. Six semi-structured focus group interviews were then held to compare perceptions of fish and LC n-3 PUFA consumption in participants of the trial and control individuals from the host institution. A number of…

Subjects/Keywords: fish; fish oil; omega-3; dietary advice; metabolic health; adiponectin

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APA (6^th Edition):

Neale, E. P. (2012). Food or nutrients? A comparison of the effectiveness and efficacy of increased fish and long chain omega-3 polyunsaturated fatty acid supplement consumption in the context of metabolic health. (Doctoral Dissertation). University of Wollongong. Retrieved from 1111 NUTRITION AND DIETETICS ; https://ro.uow.edu.au/theses/3585

Chicago Manual of Style (16^th Edition):

Neale, Elizabeth Phillipa. “Food or nutrients? A comparison of the effectiveness and efficacy of increased fish and long chain omega-3 polyunsaturated fatty acid supplement consumption in the context of metabolic health.” 2012. Doctoral Dissertation, University of Wollongong. Accessed March 01, 2021. 1111 NUTRITION AND DIETETICS ; https://ro.uow.edu.au/theses/3585.

MLA Handbook (7^th Edition):

Neale, Elizabeth Phillipa. “Food or nutrients? A comparison of the effectiveness and efficacy of increased fish and long chain omega-3 polyunsaturated fatty acid supplement consumption in the context of metabolic health.” 2012. Web. 01 Mar 2021.

Vancouver:

Neale EP. Food or nutrients? A comparison of the effectiveness and efficacy of increased fish and long chain omega-3 polyunsaturated fatty acid supplement consumption in the context of metabolic health. [Internet] [Doctoral dissertation]. University of Wollongong; 2012. [cited 2021 Mar 01]. Available from: 1111 NUTRITION AND DIETETICS ; https://ro.uow.edu.au/theses/3585.

Council of Science Editors:

Neale EP. Food or nutrients? A comparison of the effectiveness and efficacy of increased fish and long chain omega-3 polyunsaturated fatty acid supplement consumption in the context of metabolic health. [Doctoral Dissertation]. University of Wollongong; 2012. Available from: 1111 NUTRITION AND DIETETICS ; https://ro.uow.edu.au/theses/3585

29. Nogues, Perrine. Impact de l’obésité maternelle sur les fonctions placentaires : rôles de la leptine et de l'adiponectine : Impact of maternal obesity on placental functions : roles of leptin and adiponectin.

Degree: Docteur es, Sciences de la vie et de la santé, 2019, Université Paris-Saclay (ComUE)

URL: http://www.theses.fr/2019SACLV101

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L’obésité se définit par une accumulation excessive de masse grasse et une inflammation systémique chronique. Elle se mesure par un indice de masse corporelle supérieur… (more)

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L’obésité se définit par une accumulation excessive de masse grasse et une inflammation systémique chronique. Elle se mesure par un indice de masse corporelle supérieur à 30 kg/m². L’obésité maternelle est associée à de nombreux troubles de la santé et en particulier à un risque accru de développer des pathologies de la grossesse (pré éclampsie, diabète gestationnel). D’autre part, l’obésité maternelle impacte la descendance avec une augmentation des risques d’apparition de maladies métaboliques à l’âge adulte.Le placenta est un organe présent à l’interface entre la mère et le fœtus. Il assure des fonctions endocrines, d’échanges et de protection immunitaire.La leptine et l’adiponectine sont des adipokines majoritairement produites par le tissu adipeux. La leptine joue un rôle satiétogène et l’adiponectine exerce des effets insulino-sensibilisateurs. Elles sont donc impliquées dans l’homéostasie énergétique.Le placenta exprime la leptine et les récepteurs spécifiques de ces deux hormones. Il est bien établi que la leptine et l’adiponectine participent au contrôle des fonctions placentaires.Au cours de ce travail, nous nous sommes intéressés à l’impact de l’obésité maternelle (sans diabète gestationnel) sur les principales fonctions du placenta humain.Dans une première partie, nous avons montré que l’obésité maternelle entraîne i) une diminution de l’expression des transporteurs de nutriments, ii) une diminution du nombre de cellules immunitaires, iii) une altération des capillaires fœtaux et iv) une diminution de la production de cytokines pro-inflammatoires et de l’hormone chorionique gonadotrope (hCG) dans le placenta à terme.Dans une deuxième partie, nous avons montré que l’obésité maternelle altère l’expression des systèmes leptine et adiponectine (ligand et récepteurs) dans le placenta humain. En effet, l’obésité maternelle conduit à une diminution de l’expression des récepteurs des deux hormones et à une modification de la méthylation des régions promotrices des gènes codant pour les deux adipokines et leurs récepteurs.L’ensemble de ces résultats montre que l’obésité maternelle altère les fonctions endocrines, d’échanges et immunitaires du placenta. Cet organe transitoire semble s’adapter à un environnement maternel délétère.

This research investigates the impact of maternal obesity without gestational diabetes on the major functions of the human placenta. Obesity is defined as an excessive accumulation of fat mass and chronic low grade inflammation. Obesity is indicated by a body mass index (BMI) higher than 30 m2/kg. Maternal obesity is associated with health disorders and creates a higher risk for the development of pregnancy complications (pre-eclampsia and gestational diabetes). In addition to obesity having an impact on a pregnant woman, the fetus is also at risk of developing metabolic disorders in adulthood.The placenta is the organ present at the interface between the mother and the fetus. The placenta’s role is to ensure endocrine functions, exchange functions, and immune protection.Leptin and…

Advisors/Committee Members: Dieudonné, Marie-Noëlle (thesis director).

Subjects/Keywords: Leptine; Programmation foetale; Adiponectine; Fetal programming; Adiponectin; Leptin; 616.398; 618.3

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Nogues, P. (2019). Impact de l’obésité maternelle sur les fonctions placentaires : rôles de la leptine et de l'adiponectine : Impact of maternal obesity on placental functions : roles of leptin and adiponectin. (Doctoral Dissertation). Université Paris-Saclay (ComUE). Retrieved from http://www.theses.fr/2019SACLV101

Chicago Manual of Style (16^th Edition):

Nogues, Perrine. “Impact de l’obésité maternelle sur les fonctions placentaires : rôles de la leptine et de l'adiponectine : Impact of maternal obesity on placental functions : roles of leptin and adiponectin.” 2019. Doctoral Dissertation, Université Paris-Saclay (ComUE). Accessed March 01, 2021. http://www.theses.fr/2019SACLV101.

MLA Handbook (7^th Edition):

Nogues, Perrine. “Impact de l’obésité maternelle sur les fonctions placentaires : rôles de la leptine et de l'adiponectine : Impact of maternal obesity on placental functions : roles of leptin and adiponectin.” 2019. Web. 01 Mar 2021.

Vancouver:

Nogues P. Impact de l’obésité maternelle sur les fonctions placentaires : rôles de la leptine et de l'adiponectine : Impact of maternal obesity on placental functions : roles of leptin and adiponectin. [Internet] [Doctoral dissertation]. Université Paris-Saclay (ComUE); 2019. [cited 2021 Mar 01]. Available from: http://www.theses.fr/2019SACLV101.

Council of Science Editors:

Nogues P. Impact de l’obésité maternelle sur les fonctions placentaires : rôles de la leptine et de l'adiponectine : Impact of maternal obesity on placental functions : roles of leptin and adiponectin. [Doctoral Dissertation]. Université Paris-Saclay (ComUE); 2019. Available from: http://www.theses.fr/2019SACLV101

30. Lateva, Mina / Латева, Мина. Adiponectin and Some Other Metabolic Risk Markers and Their Relation to Abdominal Obesity in Preschool Children // Адипонектин и някои други маркери на метаболитен риск и тяхната връзка с абдоминалното затлъстяване при деца в предучилищна възраст.

Degree: 2015, Medical University of Varna

URL: http://repository.mu-varna.bg/handle/nls/201

► [EN] All data indicate that obesity among children in Bulgaria is not only present but also a progressive phenomenon requiring serious scientific analysis and public… (more)

▼ [EN] All data indicate that obesity among children in Bulgaria is not only present but also a progressive phenomenon requiring serious scientific analysis and public measures for its future limitation. There is already evidence of increased risk of hypertension in relation to the degree of obesity according to our data concerning Bulgarian preschoolers. Measurement of fat mass by DXA is completely feasible in this age, safely and with very good scientific results. Previous studies concerning older age and adults, as well as our results provide strong evidence for the use of SHBG as metabolic risk marker associated with obesity. CRP ranks with similar importance.. The established adipokines as markers for metabolic risk in adults and adolescents, according to the data from our study are also applicable in this age group. With particularly good value turns to be HMW adiponectin and irisin showing interesting correlations which are subject to future adjustments. We used reference data from IDEFICS study which proved applicable to Bulgarian preschoolers. Although the physical activity at this age is physiologically higher, Bulgarian results are frightening regarding the currently considered as healthy levels. Not only do these young children do not move enough, but there is a significant deterioration from our previous research data 3 years ago! In conclusion, this work adds valuable scientific and practical data on total and abdominal obesity and associated metabolic risk in the preschool age. Adoption of appropriate preventive public, educational and family measures is necessary and without any delay. ///////// ///////// [BG] Всички данни показват, че затлъстяването сред децата у нас е не само налично, но и прогресиращо явление, изискващо сериозен научен анализ и обществени мерки за бъдещото му ограничаване. Според нашите данни сред българските деца в предучилищна възраст вече има данни за повишен риск от хипертония, във връзка със степента на затлъстяване. Изследването на количеството мастна маса чрез DXA е напълно осъществимо в тази възраст, безопасно и с много добри научни резултати. Предходните проучвания в по-голяма възраст и при възрастни, както и нашите резултати, дават стабилни данни за използването на SHBG като метаболитен рисков маркер, свързан със затлъстяването. С подобно значение е и CRP. Утвърдените при възрастни и юноши адипокини като маркери за метаболитен риск, според данните от настоящото изследване са приложими и в тази възрастова група. С особено добра стойност се оказва HMW адипонектин, а иризин показва интересни корелации, които подлежат на бъдещо доуточняване. Използваните от нас референтни стойности от европейското проучване IDEFICS се оказаха приложими за българските деца в предучилищна възраст. Макар ФА на тази възраст да е физиологично по-висока, при българските деца резултатите са плашещи що се отнася до покриване на нормите, смятани за здравословни понастоящем. Не само че тези малки деца не се движат достатъчно, но и отбелязваме значимо влошаване спрямо предходни наши изследвания от преди 3…

Subjects/Keywords: obesity; DXA mass; children; metabolic markers; adiponectin; irisin; Педиатрия / Paediatrics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Lateva, Mina / Латева, �. (2015). Adiponectin and Some Other Metabolic Risk Markers and Their Relation to Abdominal Obesity in Preschool Children // Адипонектин и някои други маркери на метаболитен риск и тяхната връзка с абдоминалното затлъстяване при деца в предучилищна възраст. (Thesis). Medical University of Varna. Retrieved from http://repository.mu-varna.bg/handle/nls/201

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Lateva, Mina / Латева, Мина. “Adiponectin and Some Other Metabolic Risk Markers and Their Relation to Abdominal Obesity in Preschool Children // Адипонектин и някои други маркери на метаболитен риск и тяхната връзка с абдоминалното затлъстяване при деца в предучилищна възраст.” 2015. Thesis, Medical University of Varna. Accessed March 01, 2021. http://repository.mu-varna.bg/handle/nls/201.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Lateva, Mina / Латева, Мина. “Adiponectin and Some Other Metabolic Risk Markers and Their Relation to Abdominal Obesity in Preschool Children // Адипонектин и някои други маркери на метаболитен риск и тяхната връзка с абдоминалното затлъстяване при деца в предучилищна възраст.” 2015. Web. 01 Mar 2021.

Vancouver:

Lateva, Mina / Латева �. Adiponectin and Some Other Metabolic Risk Markers and Their Relation to Abdominal Obesity in Preschool Children // Адипонектин и някои други маркери на метаболитен риск и тяхната връзка с абдоминалното затлъстяване при деца в предучилищна възраст. [Internet] [Thesis]. Medical University of Varna; 2015. [cited 2021 Mar 01]. Available from: http://repository.mu-varna.bg/handle/nls/201.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Lateva, Mina / Латева �. Adiponectin and Some Other Metabolic Risk Markers and Their Relation to Abdominal Obesity in Preschool Children // Адипонектин и някои други маркери на метаболитен риск и тяхната връзка с абдоминалното затлъстяване при деца в предучилищна възраст. [Thesis]. Medical University of Varna; 2015. Available from: http://repository.mu-varna.bg/handle/nls/201

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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