You searched for subject:(Adhesion).
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University of Hong Kong
1.
Hu, Menglong.
Structural studies on human PECAM-1 trans-homophilic
dimerization revealing cell adhesion mechanism.
Degree: PhD, 2017, University of Hong Kong
URL: http://hdl.handle.net/10722/241302 
► Platelet/Endothelial Cell Adhesion Molecule-1, abbreviated to PECAM-1 and also known as CD31, is a member of cell adhesion molecules. It participates in cell adhesion by…
(more)
▼ Platelet/Endothelial Cell Adhesion Molecule-1,
abbreviated to PECAM-1 and also known as CD31, is a member of cell
adhesion molecules. It participates in cell adhesion by affecting
endothelium integrity and leukocyte transmigration, immunological
reaction by regulating tolerance of immune cells and pathogenesis
of vascular diseases. The signaling transduction through PECAM-1
from outside to inside of cell is associated with either homophilic
or heterophilic binding patterns of PECAM-1. Both of the
interactions result from the extracellular region containing six
immunoglobulin-like (IgL) domains for signal induction and
cytoplasmic tail with immune-receptor tyrosine-based inhibitory
motifs for initiating downstream signal pathway in cell. However,
the detailed mechanism of trans-homophilic binding pattern of human
PECAM-1 is still unknown. Here, in this project, I resolved the
crystal structure of non-glycosylated IgL1-2 by using X-ray
crystallography. Either IgL1 or IgL2 possesses classical
immunoglobulin architecture with two beta-sheet layers anchored by
one disulfide bond. Each layer is composed of 3-6 parallel
beta-strands. The dimerization of IgL1-2 due to both hydrophilic
and hydrophobic interactions is verified by small angle X-ray
scattering method in solution. Cell adhesion assay based on
mutagenesis further proves the trans-homophilic dimerization of
human PECAM-1. Our structure provides insights into understanding
the multiple functions of PECAM-1 in endothelium integrity, immune
response, and diapedesis.
published_or_final_version
Biomedical Sciences
Doctoral
Doctor of Philosophy
Subjects/Keywords: Cell adhesion molecules; Cell adhesion
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APA (6th Edition):
Hu, M. (2017). Structural studies on human PECAM-1 trans-homophilic
dimerization revealing cell adhesion mechanism. (Doctoral Dissertation). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/241302
Chicago Manual of Style (16th Edition):
Hu, Menglong. “Structural studies on human PECAM-1 trans-homophilic
dimerization revealing cell adhesion mechanism.” 2017. Doctoral Dissertation, University of Hong Kong. Accessed February 21, 2020.
http://hdl.handle.net/10722/241302.
MLA Handbook (7th Edition):
Hu, Menglong. “Structural studies on human PECAM-1 trans-homophilic
dimerization revealing cell adhesion mechanism.” 2017. Web. 21 Feb 2020.
Vancouver:
Hu M. Structural studies on human PECAM-1 trans-homophilic
dimerization revealing cell adhesion mechanism. [Internet] [Doctoral dissertation]. University of Hong Kong; 2017. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/10722/241302.
Council of Science Editors:
Hu M. Structural studies on human PECAM-1 trans-homophilic
dimerization revealing cell adhesion mechanism. [Doctoral Dissertation]. University of Hong Kong; 2017. Available from: http://hdl.handle.net/10722/241302
Oregon State University
2.
Saini, Gaurav.
Bacterial hydrophobicity : assessment techniques, applications and extension to colloids.
Degree: PhD, Chemical Engineering, 2010, Oregon State University
URL: http://hdl.handle.net/1957/16170
► This research details laboratory assessment of bacterial hydrophobicity, variations in bacterial adhesion properties with growth and extended starvation as well as extension of this assay…
(more)
▼ This research details laboratory assessment of bacterial hydrophobicity, variations in bacterial
adhesion properties with growth and extended starvation as well as extension of this assay to colloidal hydrophobicity measurement. Hydrophobicity is an integral component of surface interactions and has been studied extensively for its role in a number of engineering and applied fields. A simple-to-do and quick experimental technique known as the Microbial
Adhesion to Hydrocarbons (MATH) test is the focus of this work. This method is based on determination of microbial hydrophobicity by differential partitioning at an aqueous-hydrocarbon interface and the results yield the hydrocarbon interaction affinity of the microbes. Though very popular, this assay still suffers from the lack of a standard protocol. As a first step in that direction, the effects of various operational parameters on MATH hydrophobicity measurements were studied. Some of the previously unexplored parameters like, absorbance wavelength, hydrocarbon saturation of aqueous media and suspension medium were found to affect the results. Application of a high concentration of a lyotrope, ammonium sulfate, was shown to enhance the MATH hydrophobicity of bacteria. Additionally, cell size measurements revealed that the affinity of sulfate ions for water molecules is the primary cause of this increase rather than cell agglomeration. Increased hydrophobicity can be beneficially employed for oral care, prevention of urinary tract infection and mixed microbial community analysis.
Bacteria are often subjected to nutrient variations in different environments which significantly alter their
adhesion to surfaces thereby affecting biofilm development and have an important bearing on biofouling. An in-depth study of variations in some of the more common
adhesion determinants (biomass, cell size and hydrophobicity) demonstrated a decrease in hydrophobicity from log-growth to stationary growth phases. Short term starvation (up to 7 days) led to significant variations in measured parameters. Starved cells were also more susceptible to hydrocarbon exposure and exhibited smaller cell sizes than growth cultures.
Colloids, the larger particle family of which bacteria are a sub-class, lack a simple assay for hydrophobicity measurement. The MATH test was successfully extended to colloidal domain (non-biological particles) and the hydrophobicity results were verified against the more traditional method- water contact angle measurement. We observed similar hydrophobicity trends, as measured by the MATH test and contact angle measurements, for most of the colloids tested in this work. This dissertation research is expected to enhance our understanding of hydrophobicity in the context of bacteria and colloids, through simple experiments, and reinforce our knowledge of the dynamic nature of bacteria.
Advisors/Committee Members: Wood, Brian D. (advisor), Dolan, Mark E. (committee member).
Subjects/Keywords: Bacterial Adhesion; Bacteria – Adhesion
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APA (6th Edition):
Saini, G. (2010). Bacterial hydrophobicity : assessment techniques, applications and extension to colloids. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/16170
Chicago Manual of Style (16th Edition):
Saini, Gaurav. “Bacterial hydrophobicity : assessment techniques, applications and extension to colloids.” 2010. Doctoral Dissertation, Oregon State University. Accessed February 21, 2020.
http://hdl.handle.net/1957/16170.
MLA Handbook (7th Edition):
Saini, Gaurav. “Bacterial hydrophobicity : assessment techniques, applications and extension to colloids.” 2010. Web. 21 Feb 2020.
Vancouver:
Saini G. Bacterial hydrophobicity : assessment techniques, applications and extension to colloids. [Internet] [Doctoral dissertation]. Oregon State University; 2010. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/1957/16170.
Council of Science Editors:
Saini G. Bacterial hydrophobicity : assessment techniques, applications and extension to colloids. [Doctoral Dissertation]. Oregon State University; 2010. Available from: http://hdl.handle.net/1957/16170
University of Hong Kong
3.
刘海培; Liu, Haipei.
AFM-based experimental investigation, numerical
simulation and theoretical modeling of mechanics of cell
adhesion.
Degree: PhD, 2014, University of Hong Kong
URL: Liu,
H.
[刘海培].
(2014).
AFM-based
experimental
investigation,
numerical
simulation
and
theoretical
modeling
of
mechanics
of
cell
adhesion.
(Thesis).
University
of
Hong
Kong,
Pokfulam,
Hong
Kong
SAR.
Retrieved
from
http://dx.doi.org/10.5353/th_b5387984
;
http://dx.doi.org/10.5353/th_b5387984
;
http://hdl.handle.net/10722/208565
► Cell-extracellular matrix and cell-cell adhesion are essential for biological processes such as cell motility, signaling, proliferation, cytoskeletal organization and gene expression. For this reason, extensive…
(more)
▼ Cell-extracellular matrix and cell-cell adhesion
are essential for biological processes such as cell motility,
signaling, proliferation, cytoskeletal organization and gene
expression. For this reason, extensive effort has been devoted in
the past few decades to measure cell adhesion as well as identify
key molecules involved. This thesis focuses on two outstanding
problems in this area, namely, how to quantitatively characterize
the adhesion between neural cells and the substrate and how to
model the turnover of adhesions in the intriguing phenomenon of
stretch-induced cell realignment.
First of all, using a combined
atomic force (AFM) and total internal reflection fluorescence
microscope (TIRFM) system a novel method was developed to
systematically and quantitatively examine the adhesion between
neurite branches and the extracellular matrix. Specifically, a
tipless AFM cantilever was used to penetrate between a
well-developed neurite and the functionalized substrate and then
gradually peel the neurite from the surface. At the same time, a
laser TIRFM was utilized to monitor the activities of different
adhesion molecules during the detaching process. This approach
provides a solution to the long-standing problem of how to
quantitatively measure neuron-extracellular matrix interactions
while, simultaneously, identify the roles of various adhesion
proteins in the process. Besides heathy neurons, testes have also
been conducted on cells affected by the Alzheimer's disease (AD)
where the influence of such disease on the mechanical response of
neural cells was demonstrated.
Secondly, to better understand the
observed peeling response of the neurite, as well as extract key
information from it, finite element (FEM) simulation was carried
out using ABAQUS. It was shown that a good fit between the
simulation results and experimental data can be achieved by
representing the adhesion between two surfaces with simple cohesive
interactions. In particular, it was found that the apparent
adhesion energy density, a quantity of central interest in cell
adhesion studies, is in the range of 0.2-0.8 mj/m2.
Last but not
the least, a mechanochemical modeling framework was developed to
investigate the mechanism of cell reorientation induced by cyclic
stretching on the substrate. It was shown that the final alignment
of cells reflects the competition between stress fiber assembly or
disassembly, focal adhesion growth or disruption, substrate
stiffening and whole-cell rotation. Predictions from the model are
consistent with a variety of experimental observations, suggesting
that the main physics of this intriguing phenomenon may have been
well captured.
publishedorfinalversion
Mechanical Engineering
Doctoral
Doctor of Philosophy
Subjects/Keywords: Cell adhesion
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APA ·
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APA (6th Edition):
刘海培; Liu, H. (2014). AFM-based experimental investigation, numerical
simulation and theoretical modeling of mechanics of cell
adhesion. (Doctoral Dissertation). University of Hong Kong. Retrieved from Liu, H. [刘海培]. (2014). AFM-based experimental investigation, numerical simulation and theoretical modeling of mechanics of cell adhesion. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5387984 ; http://dx.doi.org/10.5353/th_b5387984 ; http://hdl.handle.net/10722/208565
Chicago Manual of Style (16th Edition):
刘海培; Liu, Haipei. “AFM-based experimental investigation, numerical
simulation and theoretical modeling of mechanics of cell
adhesion.” 2014. Doctoral Dissertation, University of Hong Kong. Accessed February 21, 2020.
Liu, H. [刘海培]. (2014). AFM-based experimental investigation, numerical simulation and theoretical modeling of mechanics of cell adhesion. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5387984 ; http://dx.doi.org/10.5353/th_b5387984 ; http://hdl.handle.net/10722/208565.
MLA Handbook (7th Edition):
刘海培; Liu, Haipei. “AFM-based experimental investigation, numerical
simulation and theoretical modeling of mechanics of cell
adhesion.” 2014. Web. 21 Feb 2020.
Vancouver:
刘海培; Liu H. AFM-based experimental investigation, numerical
simulation and theoretical modeling of mechanics of cell
adhesion. [Internet] [Doctoral dissertation]. University of Hong Kong; 2014. [cited 2020 Feb 21].
Available from: Liu, H. [刘海培]. (2014). AFM-based experimental investigation, numerical simulation and theoretical modeling of mechanics of cell adhesion. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5387984 ; http://dx.doi.org/10.5353/th_b5387984 ; http://hdl.handle.net/10722/208565.
Council of Science Editors:
刘海培; Liu H. AFM-based experimental investigation, numerical
simulation and theoretical modeling of mechanics of cell
adhesion. [Doctoral Dissertation]. University of Hong Kong; 2014. Available from: Liu, H. [刘海培]. (2014). AFM-based experimental investigation, numerical simulation and theoretical modeling of mechanics of cell adhesion. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. Retrieved from http://dx.doi.org/10.5353/th_b5387984 ; http://dx.doi.org/10.5353/th_b5387984 ; http://hdl.handle.net/10722/208565
4.
Webler, Forrest.
Quantifying the Adhesion Surface Preference of the
Caulobacter crescentus Holdfast.
Degree: Biomedical Engineering, 2017, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:733559/
► Caulobacter crescentus is a gram-negative, non-pathogenic, freshwater bacterium which has recently captured the attention of researches in the multidisciplinary study of bioadhesives. C. crescentus is…
(more)
▼ Caulobacter crescentus is a gram-negative,
non-pathogenic, freshwater bacterium which has recently captured
the attention of researches in the multidisciplinary study of
bioadhesives. C. crescentus is unique in that it has evolved the
ability to adhere to surfaces with the unparalleled strength,
equivalent to a force per area of 68N/mm2, via a gel-like epoxy
secretion known as holdfast. Although the holdfast of C. crescentus
rivals all currently available adhesives, it is not yet possible to
produce a biologically-derived glue from the holdfast. Molecular
biologists have yet to uncover the complex protein structure of the
holdfast. To better understand and elucidate properties of the
Caulobacter crescentus holdfast we quantify cell density as a
function of time to determine if differences in material properties
effect the binding affinity of C. crescentus. This thesis also
presents multiple methodologies for quantifying
adhesion rates on
different substrates. Multiple assays with wild-type C. crescentus
cells indicate an average of 16.11% more surface coverage on
borosilicate glass surfaces than untreated polystyrene if cells are
incubated on the two materials for a given time ∆t. We believe that
these results are due to the surface charge profile of the
material. Slightly charged amines in the holdfast are attracted to
the more negatively charged glass leading to increased
adhesion
events whereas polystyrene is a nonpolar substrate providing less
of an electrostatic, attraction.
Advisors/Committee Members: Shukla, Anita (Reader), Pelcovits, Robert (Reader), Tang, Jay (Advisor).
Subjects/Keywords: Cell adhesion
Record Details
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APA ·
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Manager
APA (6th Edition):
Webler, F. (2017). Quantifying the Adhesion Surface Preference of the
Caulobacter crescentus Holdfast. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733559/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Webler, Forrest. “Quantifying the Adhesion Surface Preference of the
Caulobacter crescentus Holdfast.” 2017. Thesis, Brown University. Accessed February 21, 2020.
https://repository.library.brown.edu/studio/item/bdr:733559/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Webler, Forrest. “Quantifying the Adhesion Surface Preference of the
Caulobacter crescentus Holdfast.” 2017. Web. 21 Feb 2020.
Vancouver:
Webler F. Quantifying the Adhesion Surface Preference of the
Caulobacter crescentus Holdfast. [Internet] [Thesis]. Brown University; 2017. [cited 2020 Feb 21].
Available from: https://repository.library.brown.edu/studio/item/bdr:733559/.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Webler F. Quantifying the Adhesion Surface Preference of the
Caulobacter crescentus Holdfast. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733559/
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
5.
Qian, Jin.
Mechanics of Molecular Bond Clusters between Elastic Media:
Stochastic-elastic Coupling in Cell-matrix Adhesion.
Degree: PhD, Division of Engineering. Mechanics of
Solids, 2009, Brown University
URL: https://repository.library.brown.edu/studio/item/bdr:211/
► Cell-matrix adhesion depends on the collective behavior of a large number of molecular bonds. While the behavior of a single molecular bond is governed by…
(more)
▼ Cell-matrix
adhesion depends on the collective
behavior of a large number of molecular bonds. While the behavior
of a single molecular bond is governed by statistical mechanics,
continuum mechanics should be valid at a large scale. How can this
transition be modeled and can this tell us something about the
mechanics of cell
adhesion? We consider in this thesis an idealized
theoretical model of molecular bond clusters between two dissimilar
elastic media subjected to various forms of mechanical load. The
distribution of interfacial traction is assumed to obey classical
elasticity equations while the rupture and rebinding of individual
molecular bonds are governed by stochastic equations. We show that
the interfacial traction is generally shared among the molecular
bonds in a non-uniform manner governed by the elasticity of the
system. Monte Carlo simulations that combine the elastic and
stochastic descriptions are conducted to investigate the lifetime
of molecular bond clusters as a function of the loading magnitude
for given
adhesion sizes. Generally, the average cluster lifetime
asymptotically approaches infinity as the applied load is reduced
to below a critical value, defined as the
adhesion strength. The
effects of cluster size, cell/matrix modulus, rebinding rate and
loading direction on the cluster lifetime and strength are
systematically investigated. While overly simplified in a number of
aspects, the model discussed in this thesis seems to give
predictions that are broadly consistent with relevant experimental
observations on cell-matrix
adhesion. The second topic of this
thesis deals with the capillary
adhesion in insects like beetles
and blowflies. We investigate the scaling effects of wet
adhesion
mediated by a liquid bridge between a fiber and a solid surface.
The influences of liquid volume and contact angles are discussed
via a scaling law indicating that the
adhesion strength can be
enhanced by contact size reduction. Due to the negative pressure in
the liquid bridge, there exists a critical length scale at which
the system achieves the theoretical tensile strength of the liquid.
We conclude that size reduction down to a critical scale results in
optimization of the
adhesion strength.
Advisors/Committee Members: Gao, Huajian (director), Freund, Lambert (reader), Franck, Christian (reader).
Subjects/Keywords: Focal Adhesion
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APA (6th Edition):
Qian, J. (2009). Mechanics of Molecular Bond Clusters between Elastic Media:
Stochastic-elastic Coupling in Cell-matrix Adhesion. (Doctoral Dissertation). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:211/
Chicago Manual of Style (16th Edition):
Qian, Jin. “Mechanics of Molecular Bond Clusters between Elastic Media:
Stochastic-elastic Coupling in Cell-matrix Adhesion.” 2009. Doctoral Dissertation, Brown University. Accessed February 21, 2020.
https://repository.library.brown.edu/studio/item/bdr:211/.
MLA Handbook (7th Edition):
Qian, Jin. “Mechanics of Molecular Bond Clusters between Elastic Media:
Stochastic-elastic Coupling in Cell-matrix Adhesion.” 2009. Web. 21 Feb 2020.
Vancouver:
Qian J. Mechanics of Molecular Bond Clusters between Elastic Media:
Stochastic-elastic Coupling in Cell-matrix Adhesion. [Internet] [Doctoral dissertation]. Brown University; 2009. [cited 2020 Feb 21].
Available from: https://repository.library.brown.edu/studio/item/bdr:211/.
Council of Science Editors:
Qian J. Mechanics of Molecular Bond Clusters between Elastic Media:
Stochastic-elastic Coupling in Cell-matrix Adhesion. [Doctoral Dissertation]. Brown University; 2009. Available from: https://repository.library.brown.edu/studio/item/bdr:211/
Penn State University
6.
Chorpenning, Katherine Ann.
Platelet Adhesion to Polyurethane Urea Under Cardiac
Pulse.
Degree: M. Eng., Bioengineering, 2010, Penn State University
URL: https://etda.libraries.psu.edu/catalog/10765
► Platelet adhesion to an artificial surface is a key event in thrombus development for cardiovascular devices. Polyurethane urea (PUU) is one widely used biomaterial in…
(more)
▼ Platelet adhesion to an artificial surface is a key
event in thrombus development for cardiovascular devices.
Polyurethane urea (PUU) is one widely used biomaterial in the
medical device industry today due to its desirable mechanical and
blood compatibility properties. The goal of the present work is to
test the platelet adhesion properties of PUU under simulated
physiologic conditions. A rotating disk system (RDS) is used to
deliver a “cardiac pulse” to a stainless steel disk with PUU
attached to the bottom surface. This pulse simulates the mean
velocities typically seen at the inlet of a left ventricular assist
device during the cardiac cycle. Using a rotating disk provides a
well-defined flow that spans a large shear rate range. The metal
disk and material rotate in platelet rich plasma (PRP) obtained
from bovine blood. Platelet adherence is quantified by
immunofluorescent labeling using CAPP2A mouse anti-bovine
αIIbβ3 antibody and Alexa-Fluor 488 donkey
anti-mouse IgG. Two approaches were used to identify shear rates
with high levels of platelet adhesion. The first method applied a
cardiac pulse continuously to a 15 mm disk for 2 hr. The average
adhesion coefficient (AC%) was 0.60% at the center, which is
comparable to the values seen for a steady 2 hr rotation at 283 rpm
(AC% = 0.36%). In the second study, platelets were pre-adhered to
the material surface and a cardiac pulse was applied continuously
for 30 min. At the disk center, 33% of the original platelet number
remained following the 30 min pulse. This value decreased to 10% at
300 s-1 (3 mm radius) and 5% at 840 s-1 (8 mm radius). Steady
rotation and cardiac pulse experiments all showed low platelet
adhesion for shear rates higher than 500 s-1. This is the highest
shear rate at which a platelet can adhere to a polyurethane surface
and is a current standard for many cardiovascular
applications.
Subjects/Keywords: platelet; adhesion
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APA (6th Edition):
Chorpenning, K. A. (2010). Platelet Adhesion to Polyurethane Urea Under Cardiac
Pulse. (Masters Thesis). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/10765
Chicago Manual of Style (16th Edition):
Chorpenning, Katherine Ann. “Platelet Adhesion to Polyurethane Urea Under Cardiac
Pulse.” 2010. Masters Thesis, Penn State University. Accessed February 21, 2020.
https://etda.libraries.psu.edu/catalog/10765.
MLA Handbook (7th Edition):
Chorpenning, Katherine Ann. “Platelet Adhesion to Polyurethane Urea Under Cardiac
Pulse.” 2010. Web. 21 Feb 2020.
Vancouver:
Chorpenning KA. Platelet Adhesion to Polyurethane Urea Under Cardiac
Pulse. [Internet] [Masters thesis]. Penn State University; 2010. [cited 2020 Feb 21].
Available from: https://etda.libraries.psu.edu/catalog/10765.
Council of Science Editors:
Chorpenning KA. Platelet Adhesion to Polyurethane Urea Under Cardiac
Pulse. [Masters Thesis]. Penn State University; 2010. Available from: https://etda.libraries.psu.edu/catalog/10765
University of Houston
7.
Sharma, Sumedha.
Bacterial Adhesion and Motility on Silanized Glass Surfaces.
Degree: Chemical and Biomolecular Engineering, Department of, 2016, University of Houston
URL: http://hdl.handle.net/10657/3532
► Attachment of bacteria to surfaces is the first step in the formation of biofilms. Medical, industrial, and technological applications require effective control over biofilm formation,…
(more)
▼ Attachment of bacteria to surfaces is the first step in the formation of biofilms. Medical, industrial, and technological applications require effective control over biofilm formation, and control of initial bacterial attachment is a potential alternate approach to conventional techniques to promote or suppress biofilm formation. Conventional use of antibiotics and bactericidal agents as antifouling techniques has adverse environmental implications1 and potentially lead to evolution of antibiotic resistant strains of bacteria.2 Controlling the initial attachment step in biofilm formation circumvents these disadvantages associated with conventional approaches. Rational design of surfaces to control bacterial attachment, however, requires fundamental understanding of bacteria-surface interactions and
adhesion mechanisms. In this work, we investigate the
adhesion of bacteria on surfaces of controlled physical properties to obtain a mechanistic understanding of
adhesion and near surface mobility of bacteria.
First, we study the deposition behavior of Escherichia coli from flow on surfaces of controlled charge, wettability, and energy created by self-assembly of organosilanes on glass. We use high throughput bacteria tracking algorithms to analyze the trajectories for hundreds of bacteria. We characterize surface-associated motion of attached cells and find that a motility metric based on extent of motion mediated by flagella is inversely correlated with rate of bacterial deposition, whereas conventional surface characterization metrics are not well correlated. The transition from transient initial attachment to irreversible attachment is also correlated to deposition rate. Our results suggest that the techniques and methods presented here to characterize transient surface motility can potentially serve as a metric to rapidly determine the efficacy of surfaces to reduce fouling by bacteria.
Next, we characterize the near-surface mobility associated with
adhesion in E. coli bacteria deposited from flow at varying shear stresses on glass substrates bearing self-assembled alkylsilane and fluoroalkylsilane layers. We find that deposition of bacteria decreases with shear stress and increases with surface roughness. Bacteria also exhibit mobile
adhesion on very smooth surfaces resulting in large linear displacements in the direction of flow which is independent of flagellar expression but requires absence of fimbriae on the cell surface. Speed of mobile
adhesion decreases and residence time of cells increases as a function of increasing shear stress. Since surface roughness determines the transition from immobile to mobile
adhesion, we suggest that strategies to reduce frictional interactions between cells and surfaces, either by engineering nanoscale-smooth surfaces or by suppressing expression of cell surface adhesins such as fimbriae, may help to reduce fouling during initial deposition.
Finally, we investigate the competing effects of surface chemistry, solution ionic strength, and medium viscoelasticity on…
Advisors/Committee Members: Conrad, Jacinta C (advisor), Willson, Richard C (committee member), Robertson, Megan L (committee member), Agrawal, Ashutosh (committee member), Hu, Yandi (committee member), Arora, Dinesh K (committee member).
Subjects/Keywords: bacteria; adhesion
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APA ·
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APA (6th Edition):
Sharma, S. (2016). Bacterial Adhesion and Motility on Silanized Glass Surfaces. (Thesis). University of Houston. Retrieved from http://hdl.handle.net/10657/3532
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Sharma, Sumedha. “Bacterial Adhesion and Motility on Silanized Glass Surfaces.” 2016. Thesis, University of Houston. Accessed February 21, 2020.
http://hdl.handle.net/10657/3532.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Sharma, Sumedha. “Bacterial Adhesion and Motility on Silanized Glass Surfaces.” 2016. Web. 21 Feb 2020.
Vancouver:
Sharma S. Bacterial Adhesion and Motility on Silanized Glass Surfaces. [Internet] [Thesis]. University of Houston; 2016. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/10657/3532.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Sharma S. Bacterial Adhesion and Motility on Silanized Glass Surfaces. [Thesis]. University of Houston; 2016. Available from: http://hdl.handle.net/10657/3532
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
McGill University
8.
Couture, Clement.
The gp23/45/90 thymic adhesion complex.
Degree: PhD, Department of Experimental Medicine, 1992, McGill University
URL: http://digitool.library.mcgill.ca/thesisfile156216.pdf
► Note:
Lympho-stromal interactions have been shown to play a vital role in the control of all aspects of intrathymic T cell development. As a consequence,…
(more)
▼ Note:
Lympho-stromal interactions have been shown to play a vital role in the control of all aspects of intrathymic T cell development. As a consequence, the molecules involved in these interactions and the intracellular signals triggered in developing T cells during their interactions with the stromal elements of the thymus have become the subject of intense investigation. One model of such lympho-stromal interaction is the adhesion of CD4+cos+ thymocytes to the E-5 thymic medullary epithelial cell line. In this work, we developed a solid-phase adhesion assay to demonstrate that the interactionof C04+cos+ thymocytes with E-5 cells is mediated by a novel adhesion molecule, the gp23/45 complex, expressed by the epithelial cells. […]
Il est présentement reconnu que les interactions lympho-stromales jouent un rôle vital dans la régulation de tous les évènements associes au développement des lymphocytes T dans le thymus. En conséquence, les molécules impliqués dans ces interactions, de même que les signaux intracellulaires induits chez les thymocytes lors de ces interactions avec les éléments stromaux du thymus, font l'objet d'une intense investigation. Un modèle d'interaction lympho-stromale est l'adhérence des thymocytes CD4+CD8+ aux cellules épithéliale médullaire thymiques de la lignée E-5. Dans ce travail, nous avons développé un test d'adhérence en phase solide pour démontrer que l'adhérence des thymocytes CD4+CD8+ aux cellules E-5 est médiée par une nouvelle molécule d'adhérence, le dimère gp23/45, qui est exprimé par les cellules épithéliales. […]
Advisors/Committee Members: Potworowski, Edouard F. (Supervisor).
Subjects/Keywords: Adhesion
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Rutgers University
9.
Anand, Prachi S.
Surface modification of biodegradable and biocompatible polymer scaffolds with multifunctional self-assembled monolayers for the controlled and specific adhesion of the biomolecules.
Degree: MS, Chemistry, 2015, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/48768/
► Dynamic surfaces can be customized to form a multifunctional assembly that favors the adsorption of the proteins and the sugar molecules in a one pot…
(more)
▼ Dynamic surfaces can be customized to form a multifunctional assembly that favors the adsorption of the proteins and the sugar molecules in a one pot reaction and provides a control over the orientation and conformation of the bioactive ligands on the synthetic surface. Self-assembled monolayers SAMs), bearing bifunctional groups grant a straightforward, flexible and simplistic method to overcome the limitations posed by a biopolymer-peptide system. These bifunctional moieties on one terminus can be adhered to the synthetic biopolymer that acts as a scaffold for the assembly and on the other terminus can be tailored to attach to highly specific biomolecules such as peptides and carbohydrates . In a novel synthesis, the SAMs can be attached to the different biomolecules by multicomponent reactions (MCR). MCRs are the chemical reactions in which three or more reactants form a product. Although, these reactions have been known for a long time, but have yet to be used in the synthesis of the biological components that mimic the extracellular matrix (ECM).
Advisors/Committee Members: Sheridan, John (chair), Jordan, Frank (internal member), Huskey, Phil (internal member).
Subjects/Keywords: Biomolecules; Adhesion
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APA (6th Edition):
Anand, P. S. (2015). Surface modification of biodegradable and biocompatible polymer scaffolds with multifunctional self-assembled monolayers for the controlled and specific adhesion of the biomolecules. (Masters Thesis). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/48768/
Chicago Manual of Style (16th Edition):
Anand, Prachi S. “Surface modification of biodegradable and biocompatible polymer scaffolds with multifunctional self-assembled monolayers for the controlled and specific adhesion of the biomolecules.” 2015. Masters Thesis, Rutgers University. Accessed February 21, 2020.
https://rucore.libraries.rutgers.edu/rutgers-lib/48768/.
MLA Handbook (7th Edition):
Anand, Prachi S. “Surface modification of biodegradable and biocompatible polymer scaffolds with multifunctional self-assembled monolayers for the controlled and specific adhesion of the biomolecules.” 2015. Web. 21 Feb 2020.
Vancouver:
Anand PS. Surface modification of biodegradable and biocompatible polymer scaffolds with multifunctional self-assembled monolayers for the controlled and specific adhesion of the biomolecules. [Internet] [Masters thesis]. Rutgers University; 2015. [cited 2020 Feb 21].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48768/.
Council of Science Editors:
Anand PS. Surface modification of biodegradable and biocompatible polymer scaffolds with multifunctional self-assembled monolayers for the controlled and specific adhesion of the biomolecules. [Masters Thesis]. Rutgers University; 2015. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/48768/
University of Illinois – Urbana-Champaign
10.
Rahil, Zainab.
Cellular decision making at the nanoscale.
Degree: MS, Bioengineering, 2016, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/98323
► The well-established dependence of cell traction forces on the compliance of supporting matrices has been attributed to levels of force exerted on components in focal…
(more)
▼ The well-established dependence of cell traction forces on the compliance of supporting matrices has been attributed to levels of force exerted on components in focal contacts. Here, use of novel, force-limited nanoscale tension gauges revealed that both force and substrate deformations govern cell decision-making during initial attachment to compliant substrates. We propose a mechanical model consistent with observed behavior. Upon formation of stable cell contacts, bond tension and tether rupture govern cell attachment, spreading, and focal
adhesion maturation at force levels on individual receptors predicted by prior studies.
Advisors/Committee Members: Leckband, Deborah (advisor), Ha, Taekjip (committee member).
Subjects/Keywords: Cell adhesion
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APA (6th Edition):
Rahil, Z. (2016). Cellular decision making at the nanoscale. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/98323
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Rahil, Zainab. “Cellular decision making at the nanoscale.” 2016. Thesis, University of Illinois – Urbana-Champaign. Accessed February 21, 2020.
http://hdl.handle.net/2142/98323.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Rahil, Zainab. “Cellular decision making at the nanoscale.” 2016. Web. 21 Feb 2020.
Vancouver:
Rahil Z. Cellular decision making at the nanoscale. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2016. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/2142/98323.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Rahil Z. Cellular decision making at the nanoscale. [Thesis]. University of Illinois – Urbana-Champaign; 2016. Available from: http://hdl.handle.net/2142/98323
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Georgia Tech
11.
Gomez, Ismael J.
Utilizing pollen as a bio-organic template for tailorable multimodal adhesion.
Degree: PhD, Chemical and Biomolecular Engineering, 2013, Georgia Tech
URL: http://hdl.handle.net/1853/52963
► The interactions of microparticles, particularly those possessing nano- and microstructured asperities, play a critical role in many industrial applications. As a result, control over particle-particle…
(more)
▼ The interactions of microparticles, particularly those possessing nano- and microstructured asperities, play a critical role in many industrial applications. As a result, control over particle-particle and particle-surface interactions can be accomplished by designing microparticles with well-defined surface morphologies. Nature provides remarkable examples of evolutionary-optimized microscale biological particles with structures and/or chemistries tailored for effective
adhesion to a variety of surfaces under different dynamic and environmental conditions. Prominent among these are pollen, which possess a range of ornamentations consisting of combinations of various morphologies and feature sizes. These surface structures, provided by a highly chemically and mechanically stable outer shell, make pollen a model bioparticle for evaluating geometric effects on
adhesion.
This research aims to take advantage of pollen's unique architecture by utilizing it as a biotemplate for designing pollen-derived particles with tailorable microparticle
adhesion. In this work, the
adhesion behavior of pollen and pollen-derived particles is characterized using atomic force microscopy (AFM). Cleaned natural pollen particles were found to exhibit short-range van der Waals (VDW)
adhesion strengths that were independent of surface chemistry and scaled with the tip radius of pollen's ornamentations. Employing pollen as a core material, electrostatic interactions were utilized to controllably coat metal nanoparticles onto pollen's surface. Metal nanoparticle-coated pollen particles displayed enhanced
adhesion facilitated by multiple nanoparticle contacts with probe surfaces, while also showing potential for use as surface enhanced Raman scattering (SERS) substrates. Using pollen as a template, a layer-by-layer (LbL) surface sol-gel (SSG) technique allowed for the preparation of high-fidelity ferro- and ferrimagnetic replicas exhibiting short-range VDW-based
adhesion governed by the contact of nanocrystals present, and long-range magnetic attraction governed by the magnetic properties of ferrimagnetic pollen replicas. The results of this work highlight the feasibility of utilizing pollen as a bio-organic template and the potential for designing pollen-derived particles with tailorable
adhesion.
Advisors/Committee Members: Meredith, Carson (advisor), Beckham, Haskell W. (committee member), Behrens, Sven (committee member), Deng, Yulin (committee member), Thio, Yonathan (committee member).
Subjects/Keywords: Pollen; Adhesion
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APA ·
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APA (6th Edition):
Gomez, I. J. (2013). Utilizing pollen as a bio-organic template for tailorable multimodal adhesion. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/52963
Chicago Manual of Style (16th Edition):
Gomez, Ismael J. “Utilizing pollen as a bio-organic template for tailorable multimodal adhesion.” 2013. Doctoral Dissertation, Georgia Tech. Accessed February 21, 2020.
http://hdl.handle.net/1853/52963.
MLA Handbook (7th Edition):
Gomez, Ismael J. “Utilizing pollen as a bio-organic template for tailorable multimodal adhesion.” 2013. Web. 21 Feb 2020.
Vancouver:
Gomez IJ. Utilizing pollen as a bio-organic template for tailorable multimodal adhesion. [Internet] [Doctoral dissertation]. Georgia Tech; 2013. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/1853/52963.
Council of Science Editors:
Gomez IJ. Utilizing pollen as a bio-organic template for tailorable multimodal adhesion. [Doctoral Dissertation]. Georgia Tech; 2013. Available from: http://hdl.handle.net/1853/52963
University of Adelaide
12.
Lauder, Christopher Ian William.
Peritoneal adhesion formation and modulation.
Degree: 2011, University of Adelaide
URL: http://hdl.handle.net/2440/69662
► This thesis examines the subject of peritoneal adhesion formation following surgery in the format of a Master of Surgery by publication. A comprehensive literature review…
(more)
▼ This thesis examines the
subject of peritoneal
adhesion formation following surgery in the format of a Master of Surgery by publication. A comprehensive literature review examines all aspects of peritoneal adhesions from the basic science to the evidence supporting products aimed at
adhesion reduction. Subsequent experimental work utilises two animal models to form adhesions and test the ability of a novel gel product to reduce
adhesion formation. The gel is a hybrid hydrogel consisting of modified chitosan and dextran. These two components are combined by a chemical cross linking reaction to form an inert gel that can be applied to the site of surgery. The gel confers several beneficial properties when used to prevent adhesions. Firstly it provides a physical separation of the injured peritoneal surfaces whilst also inhibiting the ingress of fibroblasts to the area. Secondary characteristics which promote haemostasis and inhibit bacterial growth enhance the gels
adhesion reducing potential. Initially the gel was trialled in a small animal model to test varying compositions and volumes of the gel. Two different surgical models of
adhesion formation were utilised to provide a range of stimuli in the post operative period. Results from these experiments were encouraging, showing a statistically significant reduction in
adhesion formation. Following on from this initial study a large animal study was conceived to further evaluate the effectiveness of the gel in differing environments. The porcine model also allowed for a true bowel resection with anastomosis to test the safety of the gel when used in this scenario. Allied to this the gel was also trialled following adhesiolysis at the mid point of the study, while monitoring for sensitisation or toxicity to the gel. Infective complications and abscess formation proved to be a difficult hurdle to overcome in this model. As such, no significant reduction in
adhesion reformation following adhesiolysis was observed. There were however some promising results with a reduction in adhesions to the wound noted with treatment at the time of laparoscopy, as well as a reduction in adhesions involving the bowel at the study end point. The experimental work highlights the difficulties associated with peritoneal
adhesion reduction. Overcoming the numerous stimuli to
adhesion formation is not an easy task, and there remains no currently available treatment for the prevention of adhesions without certain caveats to its use. An effective product that could be used safely in practically all environments would certainly be a step forward in this branch of surgical research. It is plausible that a product such as the gel may be improved upon to show further benefit. However, long term studies will still be required to show a beneficial effect in long term outcome measures such as the incidence of small bowel obstruction.
Advisors/Committee Members: Maddern, Guy John (advisor), School of Medicine (school).
Subjects/Keywords: peritoneal adhesions; adhesion prevention; adhesion treatment
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APA (6th Edition):
Lauder, C. I. W. (2011). Peritoneal adhesion formation and modulation. (Thesis). University of Adelaide. Retrieved from http://hdl.handle.net/2440/69662
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Lauder, Christopher Ian William. “Peritoneal adhesion formation and modulation.” 2011. Thesis, University of Adelaide. Accessed February 21, 2020.
http://hdl.handle.net/2440/69662.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Lauder, Christopher Ian William. “Peritoneal adhesion formation and modulation.” 2011. Web. 21 Feb 2020.
Vancouver:
Lauder CIW. Peritoneal adhesion formation and modulation. [Internet] [Thesis]. University of Adelaide; 2011. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/2440/69662.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Lauder CIW. Peritoneal adhesion formation and modulation. [Thesis]. University of Adelaide; 2011. Available from: http://hdl.handle.net/2440/69662
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Cambridge
13.
Redmann, Anna-Lena.
Kinetics of cell attachment and spreading on hard and soft substrates.
Degree: PhD, 2019, University of Cambridge
URL: https://www.repository.cam.ac.uk/handle/1810/290385
► A very important aspect for the functioning of an organism is that cells adapt their behaviour to external stimuli. They continuously interact with their environment,…
(more)
▼ A very important aspect for the functioning of an organism is that cells adapt their behaviour to external stimuli. They continuously interact with their environment, and biochemical and physical cues can activate cellular signalling, which leads to changes in cell behaviour such as proliferation and shape. Understanding cells' interactions with their environment is also important for understanding diseases. For example mechanosensing, which is the sensing of the cell's mechanical environment, has been associated with cancer development. In order for a cell to be able to sense its mechanical environment, it needs to form attachments to the environment.
In my thesis, I have worked on three different tasks: the development of a new measurement technique and the study of initial cell adhesion and of cell spreading. When a cell from suspension first comes into contact with a substrate, it forms initial attachment bonds with proteins on the substrate surface. These bonds are mediated through integrins, which are transmembrane heterodimers, binding to the cell's environment on one side and to the cell's cytoskeleton on the other side.
I study this initial cell attachment by measuring the force needed to detach cells, called cell adhesion strength. For these experiments I built a detachment device, which allows the detachment of cells from a substrate by vibrating the substrate in liquid. The device combines cell incubation, detachment and imaging. I measured the dependence of initial integrin bond formation on external factors such as incubation temperature and substrate stiffness.
Once initial integrin bonds are formed, many different proteins are recruited to the adhesion site in order to form stronger adhesions. Amongst these proteins are signalling proteins, which direct the behaviour of the cell as a whole. One of the first cellular reactions to a substrate after initial integrin binding is cell spreading. This can be seen by the cell changing its shape from spherical to dome-like on the substrate. Because cell spreading is a very early response of a cell to a substrate, the onset time of spreading can be used as a quantitative measure for the time it takes the cell to sense a substrate and signal shape change.
In my work, I look at the distribution of the time of initial cell spreading in a population of cells. I measure this distribution under different growth conditions such as pH, change of incubation medium from DMEM to PBS, substrate stiffness and incubation temperature.
In my detachment experiments, I observe that vibration accelerates cell spreading in those cells which remain on the substrate. This is a connection between the detachment experiments and the cell spreading experiments and it shows how cells react to external forces. By changing the medium temperature in the cell detachment and cell spreading experiments, I am able to analyse the kinetics of these two processes. I use a signalling network model to analyse the internal cellular signalling path that leads from a spherical to a spread cell.
Subjects/Keywords: Cell adhesion; Cell spreading; Adhesion strength assay
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APA ·
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APA (6th Edition):
Redmann, A. (2019). Kinetics of cell attachment and spreading on hard and soft substrates. (Doctoral Dissertation). University of Cambridge. Retrieved from https://www.repository.cam.ac.uk/handle/1810/290385
Chicago Manual of Style (16th Edition):
Redmann, Anna-Lena. “Kinetics of cell attachment and spreading on hard and soft substrates.” 2019. Doctoral Dissertation, University of Cambridge. Accessed February 21, 2020.
https://www.repository.cam.ac.uk/handle/1810/290385.
MLA Handbook (7th Edition):
Redmann, Anna-Lena. “Kinetics of cell attachment and spreading on hard and soft substrates.” 2019. Web. 21 Feb 2020.
Vancouver:
Redmann A. Kinetics of cell attachment and spreading on hard and soft substrates. [Internet] [Doctoral dissertation]. University of Cambridge; 2019. [cited 2020 Feb 21].
Available from: https://www.repository.cam.ac.uk/handle/1810/290385.
Council of Science Editors:
Redmann A. Kinetics of cell attachment and spreading on hard and soft substrates. [Doctoral Dissertation]. University of Cambridge; 2019. Available from: https://www.repository.cam.ac.uk/handle/1810/290385
Delft University of Technology
14.
Cheyyar Nageswaran, P.D.
Adhesion of aggregate-binder systems:.
Degree: 2016, Delft University of Technology
URL: http://resolver.tudelft.nl/uuid:7e5631b8-4468-4f11-a9e6-f585209d94ad
► Adhesion is a difficult, but important phenomenon which needs to be addressed in the field of pavement engineering. A strong adhesion between the constituents of…
(more)
▼ Adhesion is a difficult, but important phenomenon which needs to be addressed in the field of pavement engineering. A strong
adhesion between the constituents of pavement and between the layers of the pavement is an indication of its durability. Many modern materials like rubber, fibre, epoxy binder,
adhesion promoter etc., are used as a replacement or addition to the conventional bitumen and aggregate materials in pavement construction. The introduction of these materials thus require a better understanding of their adhesive properties, which influences to a great extent, the pavement performance. Since there are no standard tests available to quantify
adhesion in pavement engineering, the study aims at developing a framework of easily implementable test procedure that can be used for the assessment of the adhesive bond between the different materials used in pavement construction. This was achieved by performing direct tension test on different types of aggregate-binder systems. As the presence of moisture is a known factor that affects
adhesion, in turn affecting performance of the pavement, the study also concentrated towards this aspect. Three types of aggregates (porphyry, diorite and sandstone), in combination with four different binders (bitumen pen70/100, SBS polymer modified bitumen, polyurethane based binder and epoxy based binder) and two
adhesion promoters (Type a and b, with variation in curing time) were tested in this study. They were subjected to low and high temperature and strain rates and the effect of moisture on these materials were also investigated. It was found from this study that the direct tension test was easily implementable, which could help the contractors and researchers in quantifying the
adhesion between the various aggregate-binder systems.
Advisors/Committee Members: Scarpas, A..
Subjects/Keywords: adhesion; adhesion promoter; binder-aggregate interaction
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APA (6th Edition):
Cheyyar Nageswaran, P. D. (2016). Adhesion of aggregate-binder systems:. (Masters Thesis). Delft University of Technology. Retrieved from http://resolver.tudelft.nl/uuid:7e5631b8-4468-4f11-a9e6-f585209d94ad
Chicago Manual of Style (16th Edition):
Cheyyar Nageswaran, P D. “Adhesion of aggregate-binder systems:.” 2016. Masters Thesis, Delft University of Technology. Accessed February 21, 2020.
http://resolver.tudelft.nl/uuid:7e5631b8-4468-4f11-a9e6-f585209d94ad.
MLA Handbook (7th Edition):
Cheyyar Nageswaran, P D. “Adhesion of aggregate-binder systems:.” 2016. Web. 21 Feb 2020.
Vancouver:
Cheyyar Nageswaran PD. Adhesion of aggregate-binder systems:. [Internet] [Masters thesis]. Delft University of Technology; 2016. [cited 2020 Feb 21].
Available from: http://resolver.tudelft.nl/uuid:7e5631b8-4468-4f11-a9e6-f585209d94ad.
Council of Science Editors:
Cheyyar Nageswaran PD. Adhesion of aggregate-binder systems:. [Masters Thesis]. Delft University of Technology; 2016. Available from: http://resolver.tudelft.nl/uuid:7e5631b8-4468-4f11-a9e6-f585209d94ad
Harvard University
15.
Yang, Jiawei.
Hydrogel Adhesion.
Degree: PhD, 2019, Harvard University
URL: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42106933
► Hydrogel adhesion, integrating hydrogels with a variety of materials, has advanced emerging technologies in the fields of functional materials, soft ionotronics and electronics, and biomedical…
(more)
▼ Hydrogel
adhesion, integrating hydrogels with a variety of materials, has advanced emerging technologies in the fields of functional materials, soft ionotronics and electronics, and biomedical applications. However, achieving strong
adhesion between hydrogels and other materials is fundamentally challenging. This thesis explores various ways to develop chemistry of bonds, mechanics of dissipation, and topology of connecting materials to create strong hydrogel
adhesion with diverse materials, and demonstrates potential applications in medicine and engineering.
In medical practices, strong
adhesion between hydrogel and biological tissues is important. Existing adhesives are either cytotoxic, adhere weakly to tissues, or cannot be used in wet environments. We design a bio-inspired adhesives consisting of two layers: an adhesive layer made of polymer chains and a dissipative layer made of a hydrogel capable of dissipation. The polymer chains can interpenetrate into both hydrogel and tissue, and form electrostatic interactions, covalent bonds, and physical interpenetration with the polymer networks of the hydrogel and the tissue. The two layers synergistically lead to higher
adhesion energy on various tissues than existing tissue adhesives.
Adhesion occurs within minutes, independent of blood exposure, and compatible with in vivo dynamic movements.
This class of tough adhesive is promising in tissue
adhesion, but the
adhesion restricts to specific functional groups from both materials. To address this issue, we develop a topological
adhesion that uses bio-compatible polymer chains to form a network, in topological entanglement with the two polymer networks of the hydrogel and the tissue, stitching them together like a suture at the molecular scale. This approach does not require functional groups from both materials, and the interface is mechanically compatible with soft hydrogels and tissues. To illustrate the principle, pH is used to trigger several polymers to form networks, and strong
adhesion can be created between hydrogels in full range of pH, and between hydrogels and tissues. The molecular suture can be further designed to be permanent, transient, or removable on-demand.
In developing the bonding methods so far, we realize the ways to achieve hydrogel
adhesion multiply considerably by examining another aspect of
adhesion: the topology of connecting materials. Topologies in existing methods are limited. Topologies of numerous varieties are possible, but have not been explored. To illustrate the potential, we delve into a specific bond-stitch topology, study its chemistry and physics, and highlight the synergy of chemistry, mechanics, and topology can enable strong
adhesion between any hydrogels and any materials. The diversity of topologies benefits the
adhesion to accommodate different materials and manufacturing processes, and also facilitates functional
adhesion for various purposes.
We study the mechanics of
adhesion. We conduct slow crack tests to identify the failure mechanism in the debonding of…
Advisors/Committee Members: Suo, Zhigang (advisor), Mooney, David J. (committee member), Vlassak, Joost J. (committee member), Hutchinsion, John W. (committee member), Rice, James R. (committee member).
Subjects/Keywords: Hydrogel; adhesion; chemistry; mechanics; topology; adhesion operations
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APA (6th Edition):
Yang, J. (2019). Hydrogel Adhesion. (Doctoral Dissertation). Harvard University. Retrieved from http://nrs.harvard.edu/urn-3:HUL.InstRepos:42106933
Chicago Manual of Style (16th Edition):
Yang, Jiawei. “Hydrogel Adhesion.” 2019. Doctoral Dissertation, Harvard University. Accessed February 21, 2020.
http://nrs.harvard.edu/urn-3:HUL.InstRepos:42106933.
MLA Handbook (7th Edition):
Yang, Jiawei. “Hydrogel Adhesion.” 2019. Web. 21 Feb 2020.
Vancouver:
Yang J. Hydrogel Adhesion. [Internet] [Doctoral dissertation]. Harvard University; 2019. [cited 2020 Feb 21].
Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42106933.
Council of Science Editors:
Yang J. Hydrogel Adhesion. [Doctoral Dissertation]. Harvard University; 2019. Available from: http://nrs.harvard.edu/urn-3:HUL.InstRepos:42106933
Nanyang Technological University
16.
Cai, Ning.
Cell adhesion behavior on molecularly engineered surfaces
.
Degree: 2010, Nanyang Technological University
URL: http://hdl.handle.net/10356/47458
► Effective attachment of cells on biomaterials is one important requirement in designing engineered tissue substitute in application of tissue engineering. Engineering biomaterials surface with biomolecules…
(more)
▼ Effective attachment of cells on biomaterials is one important requirement in designing engineered tissue substitute in application of tissue engineering. Engineering biomaterials surface with biomolecules including ECM proteins is a widely-used method to enhance cell adhesion. The advancement in tissue engineering requires the design of optimized biomaterial surface to facilitate tissue regeneration, which relies on a better understanding of cell adhesion behavior on engineered biomaterial surfaces. In this work, poly(lactic acid) (PLA) and carbon nanotubes (CNT), chosen as the representative of conventional biomaterials and novel nano-biomaterials, respectively, were surface-modified with ECM proteins, collagen type I (COL) and fibronectin (FN), to improve their compatibility.
Subjects/Keywords: Cell adhesion behavior
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APA (6th Edition):
Cai, N. (2010). Cell adhesion behavior on molecularly engineered surfaces
. (Thesis). Nanyang Technological University. Retrieved from http://hdl.handle.net/10356/47458
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Cai, Ning. “Cell adhesion behavior on molecularly engineered surfaces
.” 2010. Thesis, Nanyang Technological University. Accessed February 21, 2020.
http://hdl.handle.net/10356/47458.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Cai, Ning. “Cell adhesion behavior on molecularly engineered surfaces
.” 2010. Web. 21 Feb 2020.
Vancouver:
Cai N. Cell adhesion behavior on molecularly engineered surfaces
. [Internet] [Thesis]. Nanyang Technological University; 2010. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/10356/47458.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Cai N. Cell adhesion behavior on molecularly engineered surfaces
. [Thesis]. Nanyang Technological University; 2010. Available from: http://hdl.handle.net/10356/47458
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Penn State University
17.
Chittiprolu, Srilatha.
Effect of starch spherulites on survival of bifidobacteria
in the presence of acid or bile.
Degree: MS, Food Science, 2008, Penn State University
URL: https://etda.libraries.psu.edu/catalog/9298
► Probiotics are live microorganisms which have been shown to confer a health benefit on the host, when administered in sufficient amounts. Many of the probiotic…
(more)
▼ Probiotics are live microorganisms which have been
shown to confer a health benefit on the host, when administered in
sufficient amounts. Many of the probiotic bacteria currently used
in foods and dietary supplements are members of Lactic Acid
Bacteria. Strains of the genus Bifidobacterium are widely used as
probiotics for human consumption. Bifidobacteria are often
sensitive to stresses encountered during production and storage of
food and during passage through the gastrointestinal tract. Thus,
the overall purpose of this research was to determine if adhesion
of bifidobacteria to starch-based spherulites can improve their
survival when exposed to acid or bile. The first objective of this
work was to develop a procedure to prepare spherulites in adequate
quantities for use in adhesion and survival studies. Spherulites
were prepared successfully in a Parr reactor (pressure vessel)
using potato starch, high amylose maize starch (Hylon VII) and
purified potato amylose. Conditions were developed to dry
spherulites using vacuum filtration and solvent dehydration.
Spherulites were characterized with respect to size (particle size
analysis) and shape (optical microscopy). Similar morphology and
size were observed for both washed and dried spherulites. The
second objective was to determine if a variety of bifidobacterial
strains could adhere to potato amylose spherulites and high amylose
maize starch granules. The strains differed in their ability to
adhere to spherulites and Hylon VII with adhesion to spherulites
significantly higher (p = 0.001) than Hylon VII for the majority of
the strains. The final objective was to investigate the protective
effect of adherence of bifidobacteria to spherulites or Hylon VII
on their survival when exposed to acid or bile. Adhesion to
spherulites or Hylon VII did not improve the survival of
bifidobacteria. The number of bifidobacteria surviving after 3 h
exposure to acid (pH 1.8, 2.9 and 7.2) or bile (0, 0.5 and 1%
oxgall) was significantly affected by type of strain used, pH and
bile concentration. The strains analyzed were not tolerant to pH
1.8 whereas survived well at pH 2.9 and 7.2 and in bile solutions
containing 0, 0.5 and 1% oxgall.
Subjects/Keywords: Adhesion; Bifidobacteria; Spherulites
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APA (6th Edition):
Chittiprolu, S. (2008). Effect of starch spherulites on survival of bifidobacteria
in the presence of acid or bile. (Masters Thesis). Penn State University. Retrieved from https://etda.libraries.psu.edu/catalog/9298
Chicago Manual of Style (16th Edition):
Chittiprolu, Srilatha. “Effect of starch spherulites on survival of bifidobacteria
in the presence of acid or bile.” 2008. Masters Thesis, Penn State University. Accessed February 21, 2020.
https://etda.libraries.psu.edu/catalog/9298.
MLA Handbook (7th Edition):
Chittiprolu, Srilatha. “Effect of starch spherulites on survival of bifidobacteria
in the presence of acid or bile.” 2008. Web. 21 Feb 2020.
Vancouver:
Chittiprolu S. Effect of starch spherulites on survival of bifidobacteria
in the presence of acid or bile. [Internet] [Masters thesis]. Penn State University; 2008. [cited 2020 Feb 21].
Available from: https://etda.libraries.psu.edu/catalog/9298.
Council of Science Editors:
Chittiprolu S. Effect of starch spherulites on survival of bifidobacteria
in the presence of acid or bile. [Masters Thesis]. Penn State University; 2008. Available from: https://etda.libraries.psu.edu/catalog/9298
University of Cambridge
18.
Bullock, James Michael Rex.
Biomechanics of the fibrillar adhesive system in insects.
Degree: PhD, 2010, University of Cambridge
URL: http://www.dspace.cam.ac.uk/handle/1810/226862https://www.repository.cam.ac.uk/bitstream/1810/226862/2/license.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/226862/5/Bullock%202010%20PhD%20Thesis.pdf.txt
;
https://www.repository.cam.ac.uk/bitstream/1810/226862/6/Bullock%202010%20PhD%20Thesis.pdf.jpg
► Many animals are able to scale smooth surfaces using adhesive structures on their feet. These organs are either soft pads with a relatively smooth surface…
(more)
▼ Many animals are able to scale smooth surfaces using adhesive structures on their feet. These organs are either soft pads with a relatively smooth surface or dense arrays of microscopic adhesive hairs with both designs having independently evolved in diverse taxa of arthropods and vertebrates. Biological adhesive pads out-perform conventional adhesives in many respects, making them important models for biomimetics. Hairy pads have attracted particular attention, because it has become feasible to fabricate similar synthetic microstructures. Nevertheless, the detailed performance and functional properties have not been characterised for any natural fibrillar adhesive system, and many fundamental aspects are still not understood. The aim of this thesis was therefore to investigate the fibrillar adhesive system of leaf beetles as a model.
To investigate the functional implications of hairy pad design, the attachment performance between hairy pads of the leaf beetle Gastrophysa viridula and smooth pads of stick insects (Carausius morosus) was compared. Adhesive and frictional stresses were found to be similar in smooth and hairy pads, inconsistent with contact splitting theory, which predicts higher adhesive stresses for fibrillar adhesives. Hairy pads showed a greater direction-dependence of friction forces than smooth pads, confirming the importance of the asymmetric design of individual setae for effortless detachment. Experiments with contaminating particles also showed that hairy pads removed contamination more rapidly and efficiently than smooth pads. Self-cleaning ability had not been previously documented for adhesive organs of insects. To investigate to what extent the hairy system is able to compensate for surface roughness, whole-body attachment forces were measured for varying roughness levels. Attachment was reduced for all length scales of surface roughness, but in particular for asperity sizes smaller than the diameter of individual seta tips.
Leaf beetles possess adhesive pads on three tarsal segments, which vary in setal morphology. However, the functional implications of this variation are unknown. The mechanical and adhesive properties of individual pads were therefore tested and their use during climbing observed. Proximal pads were shown to be stiffer than distal pads, conferring stability during pushing. In contrast, the softer distal pads allowed better attachment to rough surfaces. Hence the morphological variation is explained by an effective division of labour between the pads. To investigate an extreme example of pushing in a hairy system, pad use was studied during jumping in flea beetles. The pushing forces needed during take-off were exclusively produced by the proximal pads, again confirming the division of labour. To characterise the effects of different hair morphologies and to understand how individual setae contribute to array and whole-animal performance, single hair forces were measured using a glass capillary cantilever. Male-specific discoidal hairs were shown to be both stiffer…
Subjects/Keywords: Insect; Adhesion; Biomechanics
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APA ·
Chicago ·
MLA ·
Vancouver ·
CSE |
Export
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APA (6th Edition):
Bullock, J. M. R. (2010). Biomechanics of the fibrillar adhesive system in insects. (Doctoral Dissertation). University of Cambridge. Retrieved from http://www.dspace.cam.ac.uk/handle/1810/226862https://www.repository.cam.ac.uk/bitstream/1810/226862/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/226862/5/Bullock%202010%20PhD%20Thesis.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/226862/6/Bullock%202010%20PhD%20Thesis.pdf.jpg
Chicago Manual of Style (16th Edition):
Bullock, James Michael Rex. “Biomechanics of the fibrillar adhesive system in insects.” 2010. Doctoral Dissertation, University of Cambridge. Accessed February 21, 2020.
http://www.dspace.cam.ac.uk/handle/1810/226862https://www.repository.cam.ac.uk/bitstream/1810/226862/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/226862/5/Bullock%202010%20PhD%20Thesis.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/226862/6/Bullock%202010%20PhD%20Thesis.pdf.jpg.
MLA Handbook (7th Edition):
Bullock, James Michael Rex. “Biomechanics of the fibrillar adhesive system in insects.” 2010. Web. 21 Feb 2020.
Vancouver:
Bullock JMR. Biomechanics of the fibrillar adhesive system in insects. [Internet] [Doctoral dissertation]. University of Cambridge; 2010. [cited 2020 Feb 21].
Available from: http://www.dspace.cam.ac.uk/handle/1810/226862https://www.repository.cam.ac.uk/bitstream/1810/226862/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/226862/5/Bullock%202010%20PhD%20Thesis.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/226862/6/Bullock%202010%20PhD%20Thesis.pdf.jpg.
Council of Science Editors:
Bullock JMR. Biomechanics of the fibrillar adhesive system in insects. [Doctoral Dissertation]. University of Cambridge; 2010. Available from: http://www.dspace.cam.ac.uk/handle/1810/226862https://www.repository.cam.ac.uk/bitstream/1810/226862/2/license.txt ; https://www.repository.cam.ac.uk/bitstream/1810/226862/5/Bullock%202010%20PhD%20Thesis.pdf.txt ; https://www.repository.cam.ac.uk/bitstream/1810/226862/6/Bullock%202010%20PhD%20Thesis.pdf.jpg
Cornell University
19.
Nadermann, Nichole.
Controllable Adhesion In A Bio-Inspired Film-Terminated Fibrillar Surface
.
Degree: 2012, Cornell University
URL: http://hdl.handle.net/1813/31117
► In this dissertation we present work on the development, characterization, and analysis of an easy-to-fabricate, reusable bioinspired switchable adhesive that consists of a film-terminated fibrillar…
(more)
▼ In this dissertation we present work on the development, characterization, and analysis of an easy-to-fabricate, reusable bioinspired switchable adhesive that consists of a film-terminated fibrillar layer atop a substrate. We use a dynamic rod model and stability analysis to define and analyze the buckling of a fibril subjected to a prescribed shear displacement and a constant normal compressive force. Following this analysis, we present work on the switchable adhesive: a film-terminated fibrillar interface with two metastable states. In the first state, a thin film spanning the fibrillar surface results in strongly enhanced
adhesion due to crack-trapping. In the second state, the thin film collapses onto the substrate between fibrils and resembles a rough surface. We perform indentation experiments (pull-off and
adhesion hysteresis), which demonstrate differences in the adhesive response of the two states. We show that the adhesive state has a pull-off load up to 70 times higher than the non-adhesive state and has up to 20 times larger
adhesion hysteresis. Friction experiments show that in the collapsed state there is no static friction peak and that even in sliding friction, which is not enhanced for the adhesive state over the control samples (flat, unstructured PDMS), the collapsed state exhibits much lower sliding friction forces. We determine the pressure-to-collapse the thin film to switch from the adhesive to the non-adhesive state using hydrostatic pressure experiments. Finally, we perform both linear plate and von Kärman plate analyses on the thin film as it deforms under an applied pressure to gain insight into both bistability and the pressure required to collapse the thin film and in doing so, turn off the
adhesion. We find that the von Kärman plate theory more accurately captures the pressure required to initiate collapse of the thin film onto the substrate, most likely because of the large deflections taking place during collapse. To account for pressurization that occurs in our sealed samples during hydrostatic pressure experiments, we model the rate dependence in the hydrostatic pressure experiments. Pressurization and diffusion of gas through the thin film reduces the dependence on interfibrillar spacing.
Advisors/Committee Members: Mukherjee, Subrata (committeeMember), Gourdon, Delphine (committeeMember).
Subjects/Keywords: Bioinspired;
Adhesion;
Controllable
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MLA ·
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APA (6th Edition):
Nadermann, N. (2012). Controllable Adhesion In A Bio-Inspired Film-Terminated Fibrillar Surface
. (Thesis). Cornell University. Retrieved from http://hdl.handle.net/1813/31117
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Nadermann, Nichole. “Controllable Adhesion In A Bio-Inspired Film-Terminated Fibrillar Surface
.” 2012. Thesis, Cornell University. Accessed February 21, 2020.
http://hdl.handle.net/1813/31117.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Nadermann, Nichole. “Controllable Adhesion In A Bio-Inspired Film-Terminated Fibrillar Surface
.” 2012. Web. 21 Feb 2020.
Vancouver:
Nadermann N. Controllable Adhesion In A Bio-Inspired Film-Terminated Fibrillar Surface
. [Internet] [Thesis]. Cornell University; 2012. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/1813/31117.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Nadermann N. Controllable Adhesion In A Bio-Inspired Film-Terminated Fibrillar Surface
. [Thesis]. Cornell University; 2012. Available from: http://hdl.handle.net/1813/31117
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of New South Wales
20.
Deans, Rebecca.
Cause and effect of Asherman syndrome.
Degree: Women's & Children's Health, 2017, University of New South Wales
URL: http://handle.unsw.edu.au/1959.4/58839
;
https://unsworks.unsw.edu.au/fapi/datastream/unsworks:47714/SOURCE02?view=true
► Aim: To investigate the cause and effect of intrauterine adhesions (IUA) on reproductive function in women with Asherman syndrome (AS). Methods: Three studies have been…
(more)
▼ Aim: To investigate the cause and effect of intrauterine adhesions (IUA) on reproductive function in women with Asherman syndrome (AS). Methods: Three studies have been performed in women who have had fluoroscopically guided hysteroscopic synaechiolysis for AS in a tertiary referral unit: i) a retrospective cohort study investigating menstrual, fertility, obstetric and neonatal outcomes following surgery; ii) a retrospective cohort study investigating the efficacy of SeprafilmTM (Genzyme Corporation, Cambridge, MA) in improving menstrual fertility and obstetric outcomes;iii) an analysis of perfusion magnetic resonance imaging (MRI) investigating the total perfusion, ratio of perfusion, time to peak perfusion and gradient of perfusion to assess vascular markers of disease.Patients: 177 women diagnosed with AS, of whom 146 were trying to conceive. Results: The combined pregnancy rate was 106/146 (72.6%) women, and per unique woman, the live birth rate was 83/146 (56.8%), the miscarriage rate was 30/146 (20.5%) and the perinatal mortality rate was 4/146 (2.7%). there were 166 pregnancies in total resulting in; 97 live births, 48 miscarriages, 3 perinatal mortalities, 3 terminations of pregnancy for congenital anomalies, 4 ectopic pregnancies, and 10 ongoing pregnancies. In total, there were 98 babies born from 97 pregnancies in 83 women (1 set of twins). Maternal and perinatal morbidity included adherent placentation in 21/146 (14%), postpartum haemorrhage in 7/146 (9%), and hysterectomy in 4/146 (3%). Neonatal morbidity and mortality included prematurity in 25/98 (26%), and perinatal mortality in 4/98 (4%) of babies.
Adhesion barriers did not improve reproductive or obstetric outcomes. The uterine perfusion rates in women with grade 4 and above AS and inoperable IUA was significantly lower than those that had grade 1-3 AS and operable disease.Conclusion: Women with AS have improvement of their symptoms following surgery, including high rates of pregnancy. However, these pregnancies are complicated by maternal and fetal morbidity and mortality. Vascularity of the uterus may hold the key to understanding the pathological process behind this disorder. Perfusion MRI may also provide a prognostic tool in management of women with AS.
Advisors/Committee Members: Abbott, Jason, Women's & Children's Health, Faculty of Medicine, UNSW, Ledger, William, Women's & Children's Health, Faculty of Medicine, UNSW, Vancaillie, Thierry, Women's & Children's Health, Faculty of Medicine, UNSW.
Subjects/Keywords: Intrauterine; Asherman; Adhesion
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APA (6th Edition):
Deans, R. (2017). Cause and effect of Asherman syndrome. (Doctoral Dissertation). University of New South Wales. Retrieved from http://handle.unsw.edu.au/1959.4/58839 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:47714/SOURCE02?view=true
Chicago Manual of Style (16th Edition):
Deans, Rebecca. “Cause and effect of Asherman syndrome.” 2017. Doctoral Dissertation, University of New South Wales. Accessed February 21, 2020.
http://handle.unsw.edu.au/1959.4/58839 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:47714/SOURCE02?view=true.
MLA Handbook (7th Edition):
Deans, Rebecca. “Cause and effect of Asherman syndrome.” 2017. Web. 21 Feb 2020.
Vancouver:
Deans R. Cause and effect of Asherman syndrome. [Internet] [Doctoral dissertation]. University of New South Wales; 2017. [cited 2020 Feb 21].
Available from: http://handle.unsw.edu.au/1959.4/58839 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:47714/SOURCE02?view=true.
Council of Science Editors:
Deans R. Cause and effect of Asherman syndrome. [Doctoral Dissertation]. University of New South Wales; 2017. Available from: http://handle.unsw.edu.au/1959.4/58839 ; https://unsworks.unsw.edu.au/fapi/datastream/unsworks:47714/SOURCE02?view=true
Rutgers University
21.
Vedula, Pavan, 1988-.
Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function.
Degree: PhD, Biology, 2016, Rutgers University
URL: https://rucore.libraries.rutgers.edu/rutgers-lib/50570/
► The β-actin mRNA contains a 28 nucleotide sequence in the 3′UTR termed the zipcode which, along with a trans acting factor called the Zipcode Binding…
(more)
▼ The β-actin mRNA contains a 28 nucleotide sequence in the 3′UTR termed the zipcode which, along with a trans acting factor called the Zipcode Binding Protein-1 (ZBP-1/IMP-1), regulates the spatio-temporal expression pattern of the β-actin. This mode of post-transcriptional gene regulation is required for several cellular processes including cell migration, cell-cell
adhesion, and cell-matrix
adhesion. Adding to the list of signaling cascades such as RhoA and Src, work in this thesis demonstrates E-cadherin endocytosis, and plausibly gene expression pathways regulating cell proliferation, converge on spatially regulated β-actin translation. E-cadherin endocytosis and recycling has been shown to be important during the maintenance of epithelial adherens junctions. However in this thesis, endocytosis of E-cadherin is shown to negatively regulate adherens junction assembly, while spatially regulated β-actin translation balances this by promoting actin filament anchoring of cadherin complexes. Mislocalization of β-actin translation impairs adherens junction maturation in epithelial cells following de novo cell-cell contact. These results have implications in development and disease where the assembly and maintenance of epithelial adherens junctions is essential. In order to quantify the extent of adherens junction assembly defects in epithelial cells following de novo contact, a Fluorescence Covariance Index based on calculating Pearson’s Correlation Coefficients was developed and validated using several components of the adherens junction complex. In addition to quantitating the morphological effects of mislocalizing β-actin translation on adherens junctions, the FCI analysis showed correlation of these morphological defects with loss of epithelial barrier function. Lastly, inhibiting dynamin mediated endocytosis rescued adherens junction structure and epithelial barrier function in cells with partially mislocalized β-actin. Using Matrigel embedded 3D cyst cultures of MDCK cells, spatially regulated β-actin translation was shown to have an effect on cell shape, size and proliferation during epithelial morphogenesis. These defects in assembling a normal 3D epithelium along with disorganized acto-myosin and tight junctions, point to a role for compartmentalized β-actin translation in regulating a mechanosensitive module – plausibly Hippo and/or YAP/TAZ pathways. Finally, collective cell migration, an important paradigm in several biological processes such as wound repair and development, was used to determine the role of spatially regulated β-actin translation in epithelial wound repair. Spatially regulated β-actin translation is shown to regulate actin flux at cell-cell adhesions in leader-follower cell pairs to control tissue migration rates. Although cells with partially mislocalized β-actin translation have a more active leading edge, this increased protrusive activity fails to translate into increased migratory rate. These data taken together suggest that collective cell migration in epithelial sheets is an emergent…
Advisors/Committee Members: Weber, Gregory F (chair), Rodriguez, Alexis J (internal member), Gao, Nan (internal member), Bonder, Edward M (internal member), Hinchcliffe, Edward (outside member), Hinchcliffe, Edward H (outside member).
Subjects/Keywords: Cell adhesion molecules
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APA ·
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MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Vedula, Pavan, 1. (2016). Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function. (Doctoral Dissertation). Rutgers University. Retrieved from https://rucore.libraries.rutgers.edu/rutgers-lib/50570/
Chicago Manual of Style (16th Edition):
Vedula, Pavan, 1988-. “Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function.” 2016. Doctoral Dissertation, Rutgers University. Accessed February 21, 2020.
https://rucore.libraries.rutgers.edu/rutgers-lib/50570/.
MLA Handbook (7th Edition):
Vedula, Pavan, 1988-. “Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function.” 2016. Web. 21 Feb 2020.
Vancouver:
Vedula, Pavan 1. Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function. [Internet] [Doctoral dissertation]. Rutgers University; 2016. [cited 2020 Feb 21].
Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/50570/.
Council of Science Editors:
Vedula, Pavan 1. Spatially regulated β-actin translation in epithelia: analysis of adherens junction assembly, membrane cytoskeletal dynamics and tissue function. [Doctoral Dissertation]. Rutgers University; 2016. Available from: https://rucore.libraries.rutgers.edu/rutgers-lib/50570/
Georgia Tech
22.
Lee, Ted.
Triggerable ligand presentation using caged-RGD.
Degree: PhD, Mechanical Engineering, 2013, Georgia Tech
URL: http://hdl.handle.net/1853/52943
► Cells rely on time-dependent binding and activation by the ECM to initiate downstream signal transduction. It is unknown whether adhesion to a ligand is required…
(more)
▼ Cells rely on time-dependent binding and activation by the ECM to initiate downstream signal transduction. It is unknown whether
adhesion to a ligand is required throughout various cell processes, or only during a specified time period ("temporal threshold”). Current approaches to ligand presentation often comprise of static, constant densities of ligands. In contrast, natural cell adhesive interactions with ECMs exhibit spatiotemporal patterns of binding and activation. Therefore, a key to future research in controlling cell-material interactions will be the development of materials that can respond to external stimuli.
The objective of this project is to engineer biomaterials that present a UV-labile caged-Arginine-Glycine-Aspartic Acid (RGD) ligand and evaluate the effects on cell activities. RGD is the minimal adhesive sequence of fibronectin. By dynamically modulating adhesive ligand presentation, the effects of temporal control on cell processes can be elucidated. In this caged-peptide, a photo-labile group adjacent to the aspartic acid residue of RGD effectively “masks” a cyclo(RGDfk) peptide. Upon UV irradiation (360 nm), the caging group is released thereby restoring the adhesive activity of the peptide.
By having unparalleled spatiotemporal control of RGD ligand presentation, we demonstrated two novel tools for discovery: 1) in vivo ligand presentation to probe downstream tissue behavior and cell infiltration to biomaterial implants, and 2) in vitro ligand presentation in situ using confocal-based live cell microscopy to investigate real-time vinculin recruitment and cell traction force generation. These studies represented the first demonstration of triggerable adhesive ligand presentation in vivo and demonstrated the utility of caged-compounds for probing specific receptor-ligand responses on highly defined PEG-based hydrogels. Triggerable in vitro ligand presentation, combined with traction force microscopy, demonstrated a new research tool for investigating focal
adhesion formation and downstream force generation. Taken in whole, these results provide previously unknown insights into the importance of spatiotemporal control of adhesive ligands and created novel new research platforms for future discovery.
Advisors/Committee Members: García, Andrés (advisor), Barker, Thomas (committee member), Zhu, Cheng (committee member), Curtis, Jennifer (committee member).
Subjects/Keywords: Biomaterials; Cell adhesion
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APA ·
Chicago ·
MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
Lee, T. (2013). Triggerable ligand presentation using caged-RGD. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/52943
Chicago Manual of Style (16th Edition):
Lee, Ted. “Triggerable ligand presentation using caged-RGD.” 2013. Doctoral Dissertation, Georgia Tech. Accessed February 21, 2020.
http://hdl.handle.net/1853/52943.
MLA Handbook (7th Edition):
Lee, Ted. “Triggerable ligand presentation using caged-RGD.” 2013. Web. 21 Feb 2020.
Vancouver:
Lee T. Triggerable ligand presentation using caged-RGD. [Internet] [Doctoral dissertation]. Georgia Tech; 2013. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/1853/52943.
Council of Science Editors:
Lee T. Triggerable ligand presentation using caged-RGD. [Doctoral Dissertation]. Georgia Tech; 2013. Available from: http://hdl.handle.net/1853/52943
Georgia Tech
23.
Shin, Donglee.
Effects of pollen and metal oxide pollen replica morphology on tailorable dry and wet adhesion.
Degree: PhD, Chemical and Biomolecular Engineering, 2017, Georgia Tech
URL: http://hdl.handle.net/1853/59776
► The surface adhesion of micro-particles has been investigated with respect to many natural and environmental phenomena as well as engineering applications including drug delivery, coating,…
(more)
▼ The surface
adhesion of micro-particles has been investigated with respect to many natural and environmental phenomena as well as engineering applications including drug delivery, coating, paints, separations, and sensors. Especially, the surface
adhesion of smooth micro-particles with simple shapes (spheres, cylinders, hexahedrons) has been well-studied for the last four or five decades. However, there are far fewer studies of the
adhesion of micro-particles with complex surface morphology. In this study, pollen grains are used as experimental samples and bio-templates since the pollen grains have chemically and physically stable surface with wide shape diversity. The purpose of this study is to understand the dry and wet adhesive mechanisms of pollen and pollen replica
adhesion to tailor the magnitude and rate-dependence of the
adhesion. During the investigation of the mechanisms, we have learned: i) how to analyze quantitatively and model the attraction force of micro-particles with complex surface micro- and nano-scale morphology ii) the effects of both particle morphology and liquid physical properties on wet
adhesion of micro-particles on surfaces iii) how to tune the rate-dependence of the wet
adhesion via control of surface morphology and the structure of liquid phases. Not only do these discoveries offer insight into the mechanisms operative in Nature, but they also offer inspiration for new
adhesion mechanisms for micro-particles, particularly those that are responsive to the dynamics of particle detachment speed.
Advisors/Committee Members: Meredith, J. Carson (advisor), Reichmanis, Elsa (committee member), Shofner, Meisha (committee member), Behrens, Sven (committee member), Deng, Yulin (committee member).
Subjects/Keywords: Particle; Bio-adhesion
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APA (6th Edition):
Shin, D. (2017). Effects of pollen and metal oxide pollen replica morphology on tailorable dry and wet adhesion. (Doctoral Dissertation). Georgia Tech. Retrieved from http://hdl.handle.net/1853/59776
Chicago Manual of Style (16th Edition):
Shin, Donglee. “Effects of pollen and metal oxide pollen replica morphology on tailorable dry and wet adhesion.” 2017. Doctoral Dissertation, Georgia Tech. Accessed February 21, 2020.
http://hdl.handle.net/1853/59776.
MLA Handbook (7th Edition):
Shin, Donglee. “Effects of pollen and metal oxide pollen replica morphology on tailorable dry and wet adhesion.” 2017. Web. 21 Feb 2020.
Vancouver:
Shin D. Effects of pollen and metal oxide pollen replica morphology on tailorable dry and wet adhesion. [Internet] [Doctoral dissertation]. Georgia Tech; 2017. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/1853/59776.
Council of Science Editors:
Shin D. Effects of pollen and metal oxide pollen replica morphology on tailorable dry and wet adhesion. [Doctoral Dissertation]. Georgia Tech; 2017. Available from: http://hdl.handle.net/1853/59776
Michigan Technological University
24.
Narkar, Ameya R.
REVERSIBLY SWITCHING ADHESION OF SMART ADHESIVES INSPIRED BY MUSSEL ADHESIVE CHEMISTRY.
Degree: PhD, Department of Biomedical Engineering, 2018, Michigan Technological University
URL: https://digitalcommons.mtu.edu/etdr/741
► Catecholic groups in mussel adhesive proteins transition from being strongly adhesive in a reduced state under acidic conditions to being weakly adhesive in an…
(more)
▼ Catecholic groups in mussel adhesive proteins transition from being strongly adhesive in a reduced state under acidic conditions to being weakly adhesive in an oxidized state under basic conditions. Here, we exploit this pH responsive behavior of catechol and demonstrate that its oxidation state can be manipulated by incorporation of boronic acid to facilitate reversible transitions between strong and weak
adhesion. Our first approach involved the addition of 3- acrylamido phenylboronic acid (APBA) to dopamine methacrylamide (DMA) containing adhesives. The synthesized adhesives showed strong
adhesion to quartz surface in an acidic medium (pH 3), while weak
adhesion was observed on raising the pH to a basic value (pH 9), due to unavailability of catechol and boronic acid because of the formation of a reversible catechol-boronate complex. Boronic acid not only contributed to
adhesion at an acidic pH, but also allowed the catechol to reversibly interact with the surface in response to changing pH. In our second study, we demonstrated that addition of an anionic monomer, acrylic acid (AAc), preserved the reduced and adhesive state of catechol even at a neutral to mildly basic pH, while the addition of a cationic monomer, N-(aminopropyl) methacrylamide hydrochloride, led to the oxidized and weak adhesive state at higher basic pH values. This was due to the buffering of local pH offered by the incorporation of the ionic species, which affected the oxidation state of catechol. Although the ideal pH for formation of the complex is 9, it readily forms at neutral to mildly basic pH, leading to decreased
adhesion and limiting the adhesive’s application in physiological and marine pH environments. In our third 2 approach, adding elevated amounts of AAc to smart adhesives consisting of DMA and APBA led to strong
adhesion to quartz substrate at neutral to mildly basic pH. Moreover, the complex formed at pH 9 remained reversible and the interfacial binding could be tuned by changing the pH during successive contact cycles. pH 3 was required to break the complex and recover the strong adhesive property. Bulk adhesives analyzed in our first three approaches needed extended periods of incubation (up to 30 min) to switch between their adhesive and non-adhesive states. This is because infiltration of the pH media into the bulk polymer is limited by the slow process of diffusion. Finally, we fabricated a hybrid adhesive which was composed of gecko-inspired microstructured PDMS pillars (aspect ratios of 0.4-2) coated with the smart adhesive that we developed in our first approach. By tuning the aspect ratio of the bare templates, hybrid structures that showed strong, elevated
adhesion at pH 3, were obtained. The increased
adhesion was attributed to contact-splitting effects due to the micropatterning combined with the interfacial binding of the smart adhesive. On the other hand, formation of the complex, and the associated swelling of the adhesive together contributed to a significant decrease in
adhesion at pH 9. Additionally, the…
Advisors/Committee Members: Bruce P. Lee.
Subjects/Keywords: Mussel Adhesion; Catechol; Reversible adhesion; Smart Adhesive; Rapid adhesion; Biomaterials
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APA (6th Edition):
Narkar, A. R. (2018). REVERSIBLY SWITCHING ADHESION OF SMART ADHESIVES INSPIRED BY MUSSEL ADHESIVE CHEMISTRY. (Doctoral Dissertation). Michigan Technological University. Retrieved from https://digitalcommons.mtu.edu/etdr/741
Chicago Manual of Style (16th Edition):
Narkar, Ameya R. “REVERSIBLY SWITCHING ADHESION OF SMART ADHESIVES INSPIRED BY MUSSEL ADHESIVE CHEMISTRY.” 2018. Doctoral Dissertation, Michigan Technological University. Accessed February 21, 2020.
https://digitalcommons.mtu.edu/etdr/741.
MLA Handbook (7th Edition):
Narkar, Ameya R. “REVERSIBLY SWITCHING ADHESION OF SMART ADHESIVES INSPIRED BY MUSSEL ADHESIVE CHEMISTRY.” 2018. Web. 21 Feb 2020.
Vancouver:
Narkar AR. REVERSIBLY SWITCHING ADHESION OF SMART ADHESIVES INSPIRED BY MUSSEL ADHESIVE CHEMISTRY. [Internet] [Doctoral dissertation]. Michigan Technological University; 2018. [cited 2020 Feb 21].
Available from: https://digitalcommons.mtu.edu/etdr/741.
Council of Science Editors:
Narkar AR. REVERSIBLY SWITCHING ADHESION OF SMART ADHESIVES INSPIRED BY MUSSEL ADHESIVE CHEMISTRY. [Doctoral Dissertation]. Michigan Technological University; 2018. Available from: https://digitalcommons.mtu.edu/etdr/741
25.
Kyumurkov, Alexander.
Role of ICAP-1 in integrins' dynamic regulation, mechanosensing and contractility of osteoblast cells : Rôle d'ICAP-1 dans la régulation de la mécanosensibilité et de la contractilité des cellules ostéoblastiques via la dynamique des intégrins.
Degree: Docteur es, Biologie cellulaire, 2017, Grenoble Alpes
URL: http://www.theses.fr/2017GREAV057
► L'ICAP-1 est impliqué dans la dynamique de l'intégrine et la génération de force en contrôlant l'endocytose de l'intégrine grâce à la scission dépendant de nm23…
(more)
▼ L'ICAP-1 est impliqué dans la dynamique de l'intégrine et la génération de force en contrôlant l'endocytose de l'intégrine grâce à la scission dépendant de nm23 des puits endocycliques recouverts de chlatrine.L'ICAP-1 a été identifié comme un partenaire spécifique de l'intégrine b1 (Degani et al., 2002, Zhang et Hemler, 1999). Nous avons déjà montré que l'ICAP-1 est impliqué dans la réponse mécanisée aux cellules et la différenciation cellulaire d'une manière dépendante de l'intégrine b1 (Bouvard et al., 2007; Brunner et al., 2011; Faurobert et al., 2013; Millon-Frémillon et al. , 2008; Renz et al., 2015). Cependant, comme ICAP-1 est également capable d'adapter la migration cellulaire en réponse à la rigidité du substrat d'une manière indépendante de la β1-intégrine (Bouin et al., 2017), nous avons spéculé sur un rôle plus général de l'ICAP-1 dans l'adhésion cellulaire et dynamique d'adhérence focale. Pour cela, nous avons créé un environnement cellulaire où l'intégrine b1 et / ou l'ICAP-1 étaient absentes en utilisant quatre lignées cellulaires: les ostéoblastes WT, les cellules ostéoblastes KO de l'intégrine b1, les cellules ostéoblastes KAP ICAP-1 et les cellules ostéoblastes double KO b1 / ICAP-1 afin de surveiller le comportement de l'intégrine b3. Comme prévu, l'épuisement de l'intégrine b1 est associé à la perte d'étalement cellulaire et à la génération de force selon la mesure de la microscopie par force de traction. De manière surprenante, la suppression supplémentaire de ICAP-1 (b1 intégrine et ICAP-1 KO) conduit à la restauration de l'étalement cellulaire et de la génération de force qui dépend de l'intégrine b3. Ces forces médiées par l'intégrine b3 sont corrélées avec la diffusion lente de l'intégrine b3 dans les sites d'adhésion et le renouvellement lent de l'adhésion focale contenant l'intégrine b3 (FRAP / TIRF / vidéomicroscopie). Nous avons abordé la question de savoir si ICAP-1 pourrait réguler l'endocytose de l'intégrine b3 puisque ICAP-1 interagit avec nm23-H2 (Fournier et al., 2002), un nucléoside diphosphate kinases (NDPK) impliqué dans l'endocytose à médiation par dynamine en produisant du GTP à travers l'adénosine triphosphate (ATP) de conversion du diphosphate de guanosine (PIB) (Boissan et al., 2014). Nous montrons que la suppression de nm23 ou de dynamine ou de chlatrine dans les cellules épuisées dans l'intégrine b1 est capable d'imiter la perte combinée de l'intégrine b1 et de l'ICAP-1 en rétablissant l'étalement cellulaire, la génération de force et la dynamique de l'intégrine b3. Pour confirmer l'implication de l'ICAP-1 dans l'endocytose de l'intégrine b3, nous montrons que l'absorption de l'anticorps de l'intégrine b3 est efficacement bloquée dans les cellules épuisées dans ICAP-1. Nos résultats suggèrent que ICAP-1 pourrait être impliqué dans la dynamique de l'intégrine et la génération de force en contrôlant l'endocytose de l'intégrine grâce à la scission dépendant de nm23 des puits endocytaires de la couche de chlatrine.
ICAP-1 is involved in integrin dynamics and force…
Advisors/Committee Members: Albiges-Rizo, Corinne (thesis director).
Subjects/Keywords: Adhesion; Contractilité; Integrines; Endocytose; Dynamique d'adhesion; Adhesion; Contractility; Integrins; Endocytosis; Adhesion dynamics; 570
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APA ·
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APA (6th Edition):
Kyumurkov, A. (2017). Role of ICAP-1 in integrins' dynamic regulation, mechanosensing and contractility of osteoblast cells : Rôle d'ICAP-1 dans la régulation de la mécanosensibilité et de la contractilité des cellules ostéoblastiques via la dynamique des intégrins. (Doctoral Dissertation). Grenoble Alpes. Retrieved from http://www.theses.fr/2017GREAV057
Chicago Manual of Style (16th Edition):
Kyumurkov, Alexander. “Role of ICAP-1 in integrins' dynamic regulation, mechanosensing and contractility of osteoblast cells : Rôle d'ICAP-1 dans la régulation de la mécanosensibilité et de la contractilité des cellules ostéoblastiques via la dynamique des intégrins.” 2017. Doctoral Dissertation, Grenoble Alpes. Accessed February 21, 2020.
http://www.theses.fr/2017GREAV057.
MLA Handbook (7th Edition):
Kyumurkov, Alexander. “Role of ICAP-1 in integrins' dynamic regulation, mechanosensing and contractility of osteoblast cells : Rôle d'ICAP-1 dans la régulation de la mécanosensibilité et de la contractilité des cellules ostéoblastiques via la dynamique des intégrins.” 2017. Web. 21 Feb 2020.
Vancouver:
Kyumurkov A. Role of ICAP-1 in integrins' dynamic regulation, mechanosensing and contractility of osteoblast cells : Rôle d'ICAP-1 dans la régulation de la mécanosensibilité et de la contractilité des cellules ostéoblastiques via la dynamique des intégrins. [Internet] [Doctoral dissertation]. Grenoble Alpes; 2017. [cited 2020 Feb 21].
Available from: http://www.theses.fr/2017GREAV057.
Council of Science Editors:
Kyumurkov A. Role of ICAP-1 in integrins' dynamic regulation, mechanosensing and contractility of osteoblast cells : Rôle d'ICAP-1 dans la régulation de la mécanosensibilité et de la contractilité des cellules ostéoblastiques via la dynamique des intégrins. [Doctoral Dissertation]. Grenoble Alpes; 2017. Available from: http://www.theses.fr/2017GREAV057
26.
Kawamoto, Eiji.
LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.
Degree: 博士(医学), 2017, Mie University / 三重大学
URL: http://hdl.handle.net/10076/00017114
► LFA-1 (aLb2) and Mac-1 (aMb2) integrins regulate leukocyte trafficking in health and disease by binding primarily to IgSF ligand ICAM-1 and ICAM-2 on endothelial cells.…
(more)
▼ LFA-1 (aLb2) and Mac-1 (aMb2) integrins regulate leukocyte trafficking in health and disease by binding primarily to IgSF ligand ICAM-1 and ICAM-2 on endothelial cells. Here we have shown that the anticoagulant molecule thrombomodulin (TM), found on the surface of endothelial cells, functions as a potentially new ligand for leukocyte integrins. We generated a recombinant extracellular domain of human TM and Fc fusion protein (TM-domains 123-Fc), and showed that pheripheral blood mononuclear cells (PBMCs) bind to TM-domains 123-Fc dependent upon integrin activation. We then demonstrated that aL integrin-blocking mAb, aM integrin-blocking mAb, and b2 integrin-blocking mAb inhibited the binding of PBMCs to TM-domains 123-Fc. Furthermore, we show that the serine/threonine-rich domain (domain 3) of TM is required for the interaction with the LFA-1 (aLb2) and Mac-1 (aMb2) integrins to occur on PBMCs. These results demonstrate that the LFA-1 and Mac-1 integrins on leukocytes bind to TM, thereby establishing the molecular and structural basis underlying LFA-1 and Mac-1 integrin interaction with TM on endothelial cells. In fact, integrin-TM interactions might be involved in the dynamic regulation of leukocyte adhesion with endothelial cells.
本文 / Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine; Emergency and Critical Care Center, Mie University Hospital
8p
Subjects/Keywords: Integrin; Thrombomodulin; Inflammation; Adhesion molecules
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APA (6th Edition):
Kawamoto, E. (2017). LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin. (Thesis). Mie University / 三重大学. Retrieved from http://hdl.handle.net/10076/00017114
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Kawamoto, Eiji. “LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.” 2017. Thesis, Mie University / 三重大学. Accessed February 21, 2020.
http://hdl.handle.net/10076/00017114.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Kawamoto, Eiji. “LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin.” 2017. Web. 21 Feb 2020.
Vancouver:
Kawamoto E. LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin. [Internet] [Thesis]. Mie University / 三重大学; 2017. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/10076/00017114.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Kawamoto E. LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin. [Thesis]. Mie University / 三重大学; 2017. Available from: http://hdl.handle.net/10076/00017114
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Alberta
27.
EL Gowini, Mohamed MT.
Theoretical and Experimental Investigation on the Use of
Surface Acoustic Wave Sensors for Evaluating the Adhesion of SU-8
Thin Films.
Degree: PhD, Department of Mechanical Engineering, 2015, University of Alberta
URL: https://era.library.ualberta.ca/files/c7s75dc526
► This research investigates the use of a SU-8/AlN/Si SAW sensor for evaluating the adhesion of SU-8 thin films. A theoretical model is developed to plot…
(more)
▼ This research investigates the use of a SU-8/AlN/Si
SAW sensor for evaluating the adhesion of SU-8 thin films. A
theoretical model is developed to plot the wave dispersion profile
for the SU-8/AlN/Si configuration. A spring interface model is
utilized to represent the SU-8/AlN interface using a series of
massless springs with stiffness K (N/m3). The value of the
interface spring stiffness K is changed to represent different
levels of SU-8 adhesion. The wave dispersion profiles for the
intermediate adhesion levels are plotted using the theoretical
model. The change in wave velocity due to the change in adhesion of
the SU-8 thin film is evaluated. The sensitivities of different
configurations of the SU-8/AlN/Si SAW sensors are investigated.
Four SAW sensor designs are selected to evaluate the adhesion of
the SU-8 thin film. The four SAW sensors operate in the frequency
range of 84-208MHz. A process flow for fabricating the SAW sensors
at the University of Alberta micro-and nanofabrication facility
“nanofab” is developed. The fabricated sensors are packaged using
wire bonding to allow measurement of their frequency responses
using a Vector Network Analyzer. For each of the four SAW sensor
designs two sensor configurations will be developed. In one
configuration the SU-8 film will be patterned on top of a thin gold
film on the surface of the AlN/Si layers and in the second
configuration the gold film will be coated with an Omnicoat layer
prior to patterning the SU-8 film. Omnicoat is an adhesion promoter
that is widely used to improve the adhesion of SU-8 to gold. The
frequency responses from both sensor configurations are measured
for each of the four SAW sensor designs and the frequency shift is
evaluated. The frequency shift illustrates the change in adhesion
of the SU-8 film with and without omnicoat. The phase velocity
values also shift to a higher value for the sensor configurations
without omnicoat. As the adhesion of the SU-8 film drops in the
absence of omnicoat the stresses transferred to the SU-8 layer drop
and accordingly the wave propagation is concentrated in the AlN/Si
layers, which have a higher wave velocity than SU-8. However, in
the presence of omnicoat the adhesion of the SU-8 layer improves
and the surface acoustic wave propagates in the SU-8 layer, which
leads to a drop in the phase velocity. The theoretical model is
used to find the equivalent interface spring stiffness values for
the two cases of SU-8 adhesion i.e. with and without omnicoat. This
is accomplished by curve fitting the dispersion curves to the phase
velocity values for from both sensor configurations. The equivalent
interface spring stiffness values are found to be 8.0992 x109
N/m3 and 7.9492x109 N/m3 for the SAW sensors with omnicoat and
without omnicoat, respectively. These values indicate that when
omnicoat is used as an adhesion promoter for SU-8 the interface
spring stiffness increases due to the improved adhesion. However,
without omnicoat the adhesion of the SU-8 layer drops, which
corresponds to the lower interface spring…
Subjects/Keywords: Adhesion; Surface Acoustic Waves; MEMS
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MLA ·
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Export
to Zotero / EndNote / Reference
Manager
APA (6th Edition):
EL Gowini, M. M. (2015). Theoretical and Experimental Investigation on the Use of
Surface Acoustic Wave Sensors for Evaluating the Adhesion of SU-8
Thin Films. (Doctoral Dissertation). University of Alberta. Retrieved from https://era.library.ualberta.ca/files/c7s75dc526
Chicago Manual of Style (16th Edition):
EL Gowini, Mohamed MT. “Theoretical and Experimental Investigation on the Use of
Surface Acoustic Wave Sensors for Evaluating the Adhesion of SU-8
Thin Films.” 2015. Doctoral Dissertation, University of Alberta. Accessed February 21, 2020.
https://era.library.ualberta.ca/files/c7s75dc526.
MLA Handbook (7th Edition):
EL Gowini, Mohamed MT. “Theoretical and Experimental Investigation on the Use of
Surface Acoustic Wave Sensors for Evaluating the Adhesion of SU-8
Thin Films.” 2015. Web. 21 Feb 2020.
Vancouver:
EL Gowini MM. Theoretical and Experimental Investigation on the Use of
Surface Acoustic Wave Sensors for Evaluating the Adhesion of SU-8
Thin Films. [Internet] [Doctoral dissertation]. University of Alberta; 2015. [cited 2020 Feb 21].
Available from: https://era.library.ualberta.ca/files/c7s75dc526.
Council of Science Editors:
EL Gowini MM. Theoretical and Experimental Investigation on the Use of
Surface Acoustic Wave Sensors for Evaluating the Adhesion of SU-8
Thin Films. [Doctoral Dissertation]. University of Alberta; 2015. Available from: https://era.library.ualberta.ca/files/c7s75dc526
Texas A&M University
28.
Ibrahim, Isra.
Decorin and Biglycan Expression and Distribution during Palatal Shelf Adhesion.
Degree: 2015, Texas A&M University
URL: http://hdl.handle.net/1969.1/155168
► Understanding the molecular events in palate development is a prerequisite to more effective treatments of cleft palate. The secondary palate in humans and mice forms…
(more)
▼ Understanding the molecular events in palate development is a prerequisite to more effective treatments of cleft palate. The secondary palate in humans and mice forms from shelves of mesenchyme covered with medial edge epithelium (MEE). These shelves adhere to form the midline epithelial seam (MES). MES cells then proceed through epithelial to mesenchymal transition (EMT) and/or apoptosis to yield a fused palate.
Adhesion of opposing MEE is a crucial event whose alteration causes cleft palate. Previous studies showed that chondroitin sulphate proteoglycans (CSPG) on the apical surfaces of MEE was an important factor in palatal shelf
adhesion. In this study we investigated decorin and biglycan, being expressed in numerous craniofacial tissues, as potential proteoglycans involved in palatal shelf
adhesion.
We used a laser capture microdissection (LCM) technique to collect MEE cells and real-time polymerase chain reaction, to determine mRNA levels of decorin and biglycan that correctly reflect changes in gene expression during various stages of palatal shelf fusion (Embryonic days 13.5, 14.0 and 14.5). Both decorin and biglycan were expressed on the apical surface as well as between the MEE cells. We found that biglycan protein and mRNA levels peaked as the palatal shelves adhered. Decorin on the other hand was less abundant on the surface and had reduced mRNA levels that might be due to the regulatory effects of TGF?. Nevertheless, the temporal expression of both decorin and biglycan on the apical surface of MEE was suggestive of an important role in palatal
adhesion.
Advisors/Committee Members: Svoboda, Kathy (advisor), Ruest, Louis-Bruno (committee member), Wang, Xiaofang (committee member).
Subjects/Keywords: Decorin; Biglycan; palate adhesion
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Manager
APA (6th Edition):
Ibrahim, I. (2015). Decorin and Biglycan Expression and Distribution during Palatal Shelf Adhesion. (Thesis). Texas A&M University. Retrieved from http://hdl.handle.net/1969.1/155168
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Ibrahim, Isra. “Decorin and Biglycan Expression and Distribution during Palatal Shelf Adhesion.” 2015. Thesis, Texas A&M University. Accessed February 21, 2020.
http://hdl.handle.net/1969.1/155168.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Ibrahim, Isra. “Decorin and Biglycan Expression and Distribution during Palatal Shelf Adhesion.” 2015. Web. 21 Feb 2020.
Vancouver:
Ibrahim I. Decorin and Biglycan Expression and Distribution during Palatal Shelf Adhesion. [Internet] [Thesis]. Texas A&M University; 2015. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/1969.1/155168.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Ibrahim I. Decorin and Biglycan Expression and Distribution during Palatal Shelf Adhesion. [Thesis]. Texas A&M University; 2015. Available from: http://hdl.handle.net/1969.1/155168
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
University of Illinois – Urbana-Champaign
29.
Reale, Erik Richard.
Polyacrylamide hydrogel friction controlled by time-dependent surface energy due to poroelastic relaxation.
Degree: MS, Mechanical Engineering, 2016, University of Illinois – Urbana-Champaign
URL: http://hdl.handle.net/2142/90972
► This thesis explores the control of friction by varying contact area, contact time, and sliding speed of polyacrylamide hydrogel. With a comprehensive understanding of the…
(more)
▼ This thesis explores the control of friction by varying contact area, contact time, and sliding speed of polyacrylamide hydrogel. With a comprehensive understanding of the phenomenon, hydrogels could be designed with targeted friction behavior, and be used to design surfaces for tissue engineering and drug delivery. Polyacrylamide gels were tested to quantify how the coefficient of friction changes under different conditions. Unlike common single-phase materials, hydrogels store water within a hydrophilic polymer matrix, in which the fluid can flow under applied pressure. It is known that this mass transfer contributes to lubrication, though there is not yet a direct connection. We find that mass transfer results in a local concentration of polymer, adhering and increasing the energy needed to move contacting surfaces. The final result is a coefficient of friction which depends on sliding speed, diffusivity, elastic modulus, applied load, and surface energy.
Advisors/Committee Members: Dunn, Alison C (advisor).
Subjects/Keywords: hydrogel; tribology; poroelasticity; adhesion
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APA ·
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Export
to Zotero / EndNote / Reference
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APA (6th Edition):
Reale, E. R. (2016). Polyacrylamide hydrogel friction controlled by time-dependent surface energy due to poroelastic relaxation. (Thesis). University of Illinois – Urbana-Champaign. Retrieved from http://hdl.handle.net/2142/90972
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Reale, Erik Richard. “Polyacrylamide hydrogel friction controlled by time-dependent surface energy due to poroelastic relaxation.” 2016. Thesis, University of Illinois – Urbana-Champaign. Accessed February 21, 2020.
http://hdl.handle.net/2142/90972.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Reale, Erik Richard. “Polyacrylamide hydrogel friction controlled by time-dependent surface energy due to poroelastic relaxation.” 2016. Web. 21 Feb 2020.
Vancouver:
Reale ER. Polyacrylamide hydrogel friction controlled by time-dependent surface energy due to poroelastic relaxation. [Internet] [Thesis]. University of Illinois – Urbana-Champaign; 2016. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/2142/90972.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Reale ER. Polyacrylamide hydrogel friction controlled by time-dependent surface energy due to poroelastic relaxation. [Thesis]. University of Illinois – Urbana-Champaign; 2016. Available from: http://hdl.handle.net/2142/90972
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
30.
Moliotis, Leonidas.
Κλινικοπαθολογοανατομική μελέτη της αγγειογένεσης και μορίων κυτταρικής συνοχής σε όγκους μαλακών μορίων.
Degree: 2015, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)
URL: http://hdl.handle.net/10442/hedi/36712
► The soft tissue tumors constitute an heterogeneous group of malignant tumors which take origin from various mesenchimal cellular elements of parenchimal structures at any part…
(more)
▼ The soft tissue tumors constitute an heterogeneous group of malignant tumors which take origin from various mesenchimal cellular elements of parenchimal structures at any part of the human body and expressly in scheleta muscles, in adipose and fibrous tissue along their vessels. Diagnosis of soft tissue sarcomas is extremely difficult and the fact that these sarcomas many times are not accompanied by symptoms rends it much more difficult.After diagnosis and staging of soft tissue sarcomas,surgical excision.radiotherapy and chemotherapy are the means to treat them but surgical excision remains the most common and effective mean of treatment. Although sarcomas are relatively rare tumors, which represent less than 1% of the total number of the tumors, are characterized of an extreme agressivness and a low percentage of survival independently of the treatment’s approach. Approximately 70% of the patients develop recidivations in the first two years from the treatment. Because of the recent progress of the molecular biology, tries for the understanding of the pathogenetic meccanism of the desease which will lead us to take the right therapeutic decision usually are focused in the study of genes and proteins expression without regarding the heterogeneity of the tumor cells which compose the sarcomas.It has been demonstrated that the malignant tumors of the musculoskeletal system include a small percentage of particular cells, which are recognized only on the base of specialized superficial antigens, and which cells are called tumorigenic stem cells with the potentiality of autoconservative growth and differentiation. More and more studies designate that the tumoricenic stem cells are the progenitor cells of which the tumor is composed and that it’s biologic behavior, that is to say the capability of recidivation and metastasis as the sensitivity to chemotherapy and radiotherapy is regularized from these tumorigenic stem cells. The present study contribute to the understanding of the molecular meccanisms which determinate the function of the tumorigenic stem cells in these tumors contributing to the outer and final purpose which is the development of a new and more efficient therapy. …
Subjects/Keywords: Συνεκτικά μόρια; Adhesion molecules
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APA (6th Edition):
Moliotis, L. (2015). Κλινικοπαθολογοανατομική μελέτη της αγγειογένεσης και μορίων κυτταρικής συνοχής σε όγκους μαλακών μορίων. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/36712
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Chicago Manual of Style (16th Edition):
Moliotis, Leonidas. “Κλινικοπαθολογοανατομική μελέτη της αγγειογένεσης και μορίων κυτταρικής συνοχής σε όγκους μαλακών μορίων.” 2015. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed February 21, 2020.
http://hdl.handle.net/10442/hedi/36712.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
MLA Handbook (7th Edition):
Moliotis, Leonidas. “Κλινικοπαθολογοανατομική μελέτη της αγγειογένεσης και μορίων κυτταρικής συνοχής σε όγκους μαλακών μορίων.” 2015. Web. 21 Feb 2020.
Vancouver:
Moliotis L. Κλινικοπαθολογοανατομική μελέτη της αγγειογένεσης και μορίων κυτταρικής συνοχής σε όγκους μαλακών μορίων. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. [cited 2020 Feb 21].
Available from: http://hdl.handle.net/10442/hedi/36712.
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
Council of Science Editors:
Moliotis L. Κλινικοπαθολογοανατομική μελέτη της αγγειογένεσης και μορίων κυτταρικής συνοχής σε όγκους μαλακών μορίων. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2015. Available from: http://hdl.handle.net/10442/hedi/36712
Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
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