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You searched for subject:(Acute myocardium infarct). Showing records 1 – 2 of 2 total matches.

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1. Branco, Érika Renata. Uso da via transpericárdica para infusão de células mononucleares de medula óssea em suínos induzidos ao infarto agudo do miocárdio.

Degree: PhD, Anatomia dos Animais Domésticos e Silvestres, 2007, University of São Paulo

As doenças cardiovasculares continuam sendo a primeira causa de morte no Brasil (32%) representando a terceira maior causa de internação hospitalar. Apesar dos avanços terapêuticos das últimas décadas, estudos epidemiológicos consideram o infarto agudo do miocárdio (AMI) uma das maiores causas de morbidade e mortalidade, sendo a maioria, ligados a realização de terapias não adequadas, dos quais 50% das mortes ocorrem nas primeiras 2 horas do ocorrido e 14% morrem antes de receber atendimento médico. O objetivo deste estudo foi de avaliar a técnica de infusão transpericárdica de células mononucleares de medula óssea (CMMO) em suínos. Três suínos fêmeas, pesando 25Kg foram induzidas ao AMI, com auxilio de cateter balão colocado no 1° ramo diagonal da artéria coronária interventricular por 45 minutos, seguido por infusão de 1x108 CMMO marcadas com Hoechst® pela via transpericárdica. O grupo controle foi composto por 3 animais, os quais receberam infusão de 1x108 CMMO marcadas com Hoechst® através da mesma técnica. Os resultados revelaram distribuição homogênea das CMMO no miocárdio, concentrando-se especialmente na área infartada, enquanto que o grupo controle apresentou distribuição homogênea ao longo do miocárdio. Nós concluímos que a técnica transpericárdica é viável para infusão de CMMO em processos de isquemia cardíaca.

Cardiovascular illnesses continue to be the first cause of death in Brazil (32%), representing the third major reason of hospital internment. Although the therapeutics advances in the last decades, epidemiologic studies considered the acute myocardium infarct (AMI) to be one of the most causes of morbidity and mortality (30%), most of, related to the institution of non-adequate therapy, thereby 50% of deaths in the early two hours of the event and 14% dying before any medical assistance. Currently therapies include stent angioplasty, Thrombolytic medication and aortic-coronary venous grafting; while in experimental area the cellular therapy has been largely investigated being the cells infusion technique investigation the most enthusiastic issue. This study aimed to evaluate the transepicardic infusion technique of bone marrow mononuclear cells (BMMC) in swine. Three female swine, averaging 25 kg, were induced to AMI, with the aid of a balloon catheter displaced on the first interventricular diagonal branch of the coronary artery for 45 minutes, following to the infusion of 1x108 BMMC stained with Hoescht® by the transepicardic technique. Sham operation was carried out in three animals (Control group), which received infusion of 1x108 BMMC stained with Hoescht® by the same technique. The results revealed an inhomogeneous distribution of the BMMC in the myocardium, being more concentrated in the infarcted area, while the control group presented a homogeneous distribution along the myocardium. We concluded the transpericardic technique would be acceptable to the infusion of BMMC in cardiac ischemic processes.

Advisors/Committee Members: Miglino, Maria Angélica.

Subjects/Keywords: Acute myocardium infarct; Bone marrow mononuclear cells; Células Mononucleares de Medula Óssea; Infarto agudo do miocárdio; Transpericardic route; Via transpericárdica

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Branco, . R. (2007). Uso da via transpericárdica para infusão de células mononucleares de medula óssea em suínos induzidos ao infarto agudo do miocárdio. (Doctoral Dissertation). University of São Paulo. Retrieved from http://www.teses.usp.br/teses/disponiveis/10/10132/tde-26032008-143205/ ;

Chicago Manual of Style (16th Edition):

Branco, Érika Renata. “Uso da via transpericárdica para infusão de células mononucleares de medula óssea em suínos induzidos ao infarto agudo do miocárdio.” 2007. Doctoral Dissertation, University of São Paulo. Accessed August 23, 2019. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-26032008-143205/ ;.

MLA Handbook (7th Edition):

Branco, Érika Renata. “Uso da via transpericárdica para infusão de células mononucleares de medula óssea em suínos induzidos ao infarto agudo do miocárdio.” 2007. Web. 23 Aug 2019.

Vancouver:

Branco R. Uso da via transpericárdica para infusão de células mononucleares de medula óssea em suínos induzidos ao infarto agudo do miocárdio. [Internet] [Doctoral dissertation]. University of São Paulo; 2007. [cited 2019 Aug 23]. Available from: http://www.teses.usp.br/teses/disponiveis/10/10132/tde-26032008-143205/ ;.

Council of Science Editors:

Branco R. Uso da via transpericárdica para infusão de células mononucleares de medula óssea em suínos induzidos ao infarto agudo do miocárdio. [Doctoral Dissertation]. University of São Paulo; 2007. Available from: http://www.teses.usp.br/teses/disponiveis/10/10132/tde-26032008-143205/ ;


University of Lund

2. Ringborn, Michael. Ventricular Depolarization in Ischemic Heart Disease.Value of Electrocardiography in Assessment of Severity and Extent of Acute Myocardial Ischemia.

Degree: 2013, University of Lund

Background In patients with symptoms compatible with acute myocardial infarction (MI), early triage by ECG in the pre-hospital phase by ST-segment elevation myocardial infarction (STEMI) criteria is important for direct transport of these patients to a regional center for primary percutaneous coronary intervention (pPCI). The time from first medical contact to pPCI should, due to present guidelines, be no longer than two hours. One main determinant of final infarct size (IS), in addition to myocardium at risk (MaR) and time to treatment, is the severity of ischemia, which relates to the rate of progression of the infarction wavefront. Presently, no assessment of severity is made. Patients with severe ischemia may have changes within the QRS complex in addition to ST-T changes, making it possible to identify these high-risk patients. QRS changes are, however more difficult to determine and to quantify correctly as compared to the changes within the ST segment. Aims and methods The overall objective was to increase the understanding of depolarization changes during myocardial ischemia and to evaluate whether these changes have possible clinical implications in patients with acute MI. Different QRS methods are applied in patients during ischemia produced by elective, prolonged PCI as well as during STEMI, and comparisons are made with conventional ECG parameters as well as single-photon emission computed tomography (SPECT) images. Results and conclusions Study I compared the computer-derived high-frequency QRS components (HF-QRS) in patients with and without standard ECG changes indicative of old MI. In contrast to previous findings we found that HF-QRS cannot differentiate between patients with and without old MI. Study II tested the ability of HF-QRS versus conventional ST-segment measurements to detect and quantify myocardial ischemia, as determined by SPECT, in a group of patients undergoing elective balloon PCI. We showed that HF-QRS can provide valuable information both for detecting acute ischemia and for quantifying MaR and its severity. Study III evaluated a potentially more readily available (compared with HF-QRS) new marker of ventricular depolarization distortion, which is based on calculation of up- and downslope within the QRS complex, in patients undergoing coronary intervention that includes temporary occlusion of a coronary artery. We found that in particular the downward slope between R and S waves better correlates with ischemia than conventional QRS parameters, as quantified by SPECT, and thus can be of value in risk stratification of patients with ischemia in addition to conventional ST-segment analysis. Study IV, in a large cohort of STEMI patients, assessed the value of the conventional Sclarovsky-Birnbaum ischemia grading system that includes terminal QRS distortion in addition to ST elevation, on pre-hospital ECG and its dynamic behavior during transport time to the PCI center for prediction of final infarct size and salvage, as estimated by SPECT imaging. The study explored the temporal…

Subjects/Keywords: Kardiologi; Acute myocardial ischemia; Acute myocardial infarction; Severity of ischemia; QRS changes; HF-QRS; QRS slopes; Depolarization changes; Myocardium at risk; Final infarct size; SPECT.

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Ringborn, M. (2013). Ventricular Depolarization in Ischemic Heart Disease.Value of Electrocardiography in Assessment of Severity and Extent of Acute Myocardial Ischemia. (Doctoral Dissertation). University of Lund. Retrieved from http://lup.lub.lu.se/record/3563704 ; http://portal.research.lu.se/ws/files/4034954/3563706.pdf

Chicago Manual of Style (16th Edition):

Ringborn, Michael. “Ventricular Depolarization in Ischemic Heart Disease.Value of Electrocardiography in Assessment of Severity and Extent of Acute Myocardial Ischemia.” 2013. Doctoral Dissertation, University of Lund. Accessed August 23, 2019. http://lup.lub.lu.se/record/3563704 ; http://portal.research.lu.se/ws/files/4034954/3563706.pdf.

MLA Handbook (7th Edition):

Ringborn, Michael. “Ventricular Depolarization in Ischemic Heart Disease.Value of Electrocardiography in Assessment of Severity and Extent of Acute Myocardial Ischemia.” 2013. Web. 23 Aug 2019.

Vancouver:

Ringborn M. Ventricular Depolarization in Ischemic Heart Disease.Value of Electrocardiography in Assessment of Severity and Extent of Acute Myocardial Ischemia. [Internet] [Doctoral dissertation]. University of Lund; 2013. [cited 2019 Aug 23]. Available from: http://lup.lub.lu.se/record/3563704 ; http://portal.research.lu.se/ws/files/4034954/3563706.pdf.

Council of Science Editors:

Ringborn M. Ventricular Depolarization in Ischemic Heart Disease.Value of Electrocardiography in Assessment of Severity and Extent of Acute Myocardial Ischemia. [Doctoral Dissertation]. University of Lund; 2013. Available from: http://lup.lub.lu.se/record/3563704 ; http://portal.research.lu.se/ws/files/4034954/3563706.pdf

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