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You searched for subject:(Acute coroary syndrome). One record found.

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University of Gothenburg / Göteborgs Universitet

1. Barywani, Salim Bary. Prognostic prediction and treatment of cardiac diseases in elderly.

Degree: 2015, University of Gothenburg / Göteborgs Universitet

Aim: The overall aim of this thesis was to study the prognostic prediction and its association with treatment strategies in the elderly patients presenting with acute coronary syndrome (ACS) and left ventricular systolic heart failure (HF). Methods: A total 353 octogenarians with ACS, 182 patients treated with percutaneous coronary intervention (PCI) and 171 treated without PCI, were consecutively included and retrospectively studied for prognostic predictors of long-term all-cause mortality. Moreover, 140 patients >70 years were prospectively studied for prognostic predictors for major adverse cardiovascular events (MACE) in patients with ACS referred for coronary angiography. In case of heart failure, 182 octogenarians with left ventricular systolic HF were consecutively included and retrospectively studied for impact of different dose levels of guideline recommended neurohormonal blockades, beta-blockers (BBs) and angiotensin converting enzyme inhibitors (ACEIs)/ angiotensin receptor blockers (ARBs), on long-term mortality. Results: In ACS-cohorts: Cox-regression analysis of octogenarian patients with ACS treated with PCI showed following factors as independent predictors of 5-year all-cause mortality: atrial fi brillation, mitral regurgitation (MR), tricuspid regurgitation (TR), estimated glomerular fi ltration rate (eGFR) <30 ml/min and dependency in activities of daily living. Furthermore, in the overall cohort of octogenarians with ACS, both PCI-treated and non-PCI-treated, PCI was associated with lower 5-year all-cause mortality. At least mild grade MR was associated with higher 5-year all-cause mortality and PCI was associated with improved prognosis even in patients with MR compared with patients with MR treated without PCI. Finally, in a prospective cohort of ACS patients >70 years referred for coronary angiography, during an average follow-up of 39+11 months, 41% of the patients had one or more MACE and 24% developed post-ACS heart failure. The study cohort had as good quality of life as an age-matched reference population from Swedish normative SF-36 database in both physical health subscales (physical functioning, role physical, bodily pain and general health) and mental health subscales (Vitality, social functioning, role emotional and mental health). The all-cause mortality rate was 10%. In heart failure cohort: In octogenarians with left ventricular systolic HF treated with highest tolerable doses of neurohormonal blockades, target dose of ACEIs/ARBs were associated with improved 5-year survival rate, despite that this was achievable in only about half of the patients. No signifi cant differences in survival were found between the different doses of BBs; however the heart rate was comparable between the different dose groups. Conclusion: In elderly patients with ACS, PCI was associated with improved long-term survival despite high age. Several prognostic predictors including MR were identifi ed. Moreover, in the modern era of reperfusion therapy, despite improved quality of life and low mortality…

Subjects/Keywords: Elderly; Octogenarians; Systolich heart failure; Acute coroary syndrome; ACEI/ARB; Beta-blockers; Majour cardiovascular adverse events; Quality of life

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Barywani, S. B. (2015). Prognostic prediction and treatment of cardiac diseases in elderly. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/39561

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Barywani, Salim Bary. “Prognostic prediction and treatment of cardiac diseases in elderly.” 2015. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed November 19, 2019. http://hdl.handle.net/2077/39561.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Barywani, Salim Bary. “Prognostic prediction and treatment of cardiac diseases in elderly.” 2015. Web. 19 Nov 2019.

Vancouver:

Barywani SB. Prognostic prediction and treatment of cardiac diseases in elderly. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. [cited 2019 Nov 19]. Available from: http://hdl.handle.net/2077/39561.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Barywani SB. Prognostic prediction and treatment of cardiac diseases in elderly. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2015. Available from: http://hdl.handle.net/2077/39561

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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