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You searched for subject:(Acetaminophen Bioavailability). Showing records 1 – 3 of 3 total matches.

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Oregon State University

1. Mansell, Libbie J. New acetaminophen products : formulation development and bioavailability.

Degree: PhD, Pharmacy, 1990, Oregon State University

Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In vitro dissolution results indicate amount/thickness of film layer and sequence in which polymeric materials were applied are important factors in formulating multiple layer drug beads. A unique sustained release suspension was formulated by incorporating multilaminar polymer-coated acetaminophen beads into a suspending vehicle. Choice of suspending media, length of aging, and application of heat alter acetaminophen release from these polymer-coated beads and are likely to influence in vivo performance. Relative bioavailability and pharmacokinetic parameters for two different three-layer polymer-coated bead types were evaluated in two suspending vehicles of differing viscosity containing an immediate release dose of acetaminophen powder. These four test products were administered to 26 human subjects in a modified 4-way cross-over study and compared to two commercially available control products (immediate release acetaminophen tablets and prolonged release multi-symptom cold tablets containing acetaminophen). Saliva acetaminophen concentration were determined for a 24 hour period following administration of each dosage form and correlated to plasma concentrations. Concentration-time profiles and model-independent pharmacokinetic parameters have been determined. Computer simulations were made to determine the effect of alternative dosing regimens using a unique sustained release suspension. Results indicate achievement of sustained therapeutic plasma concentrations is possible using multiple polymer film-coated drug products. Advisors/Committee Members: Ayres, James W. (advisor), Thomas, David (committee member).

Subjects/Keywords: Acetaminophen  – Bioavailability

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APA (6th Edition):

Mansell, L. J. (1990). New acetaminophen products : formulation development and bioavailability. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/38374

Chicago Manual of Style (16th Edition):

Mansell, Libbie J. “New acetaminophen products : formulation development and bioavailability.” 1990. Doctoral Dissertation, Oregon State University. Accessed June 20, 2019. http://hdl.handle.net/1957/38374.

MLA Handbook (7th Edition):

Mansell, Libbie J. “New acetaminophen products : formulation development and bioavailability.” 1990. Web. 20 Jun 2019.

Vancouver:

Mansell LJ. New acetaminophen products : formulation development and bioavailability. [Internet] [Doctoral dissertation]. Oregon State University; 1990. [cited 2019 Jun 20]. Available from: http://hdl.handle.net/1957/38374.

Council of Science Editors:

Mansell LJ. New acetaminophen products : formulation development and bioavailability. [Doctoral Dissertation]. Oregon State University; 1990. Available from: http://hdl.handle.net/1957/38374


Oregon State University

2. Hossain, Mohammad. Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation.

Degree: PhD, Pharmacy, 1991, Oregon State University

Gastrointestinal (GI) transit data were collected using pigs as animal models. Density and size effects of non-disintegrating dosage forms on GI transit were investigated. Total GI transit times range from 2 to 33 days for 22 administrations of these nondisintegrating dosage forms. Pigs are found to not be an appropriate animal model for studying bioavailability or GI transit of non-disintegrating, non-erodible oral release dosage forms. Development of controlled release dosage forms where the mechanism of drug release is diffusion through polymeric membrane formed via film coating utilizing fluid-bed technology requires optimization of several processing and formulation variables. The influence of a processing variable (nozzle orifice opening) and a few formulation variables (individual vs. combination plasticizer, or a water-insoluble additive) on dissolution of a model drug (acetaminophen) spray coated with Aquacoat® were studied. Pharmacodynamic and pharmacokinetic information for a model drug (acetaminophen) and computer simulation were used to develop a dosage form with a 12 hour sustained release for oral administration to children and adults for maximum analgesic and antipyretic effect. Simulated plasma acetaminophen concentration-time curves were similar to observed bioavailability study profiles. In vitro and preliminary in vivo results from an adult human volunteer indicate that sustained therapeutic saliva acetaminophen concentration is possible using the newly developed acetaminophen molded tablet dosage form. The bioavailability of the new, oral controlled release acetaminophen molded tablet relative to a commercially available product (Extra-Strength Tylenol® caplet) was evaluated in 8 healthy, adult volunteers. Multiple doses of these two products were administered in a two-way cross-over design. Bioavailability of the new sustained release molded tablet is comparable to that of the immediate release product. Polymer coated acetaminophen beads were effective in maintaining saliva acetaminophen concentrations of 5 μ/ml over a 12 hour dosing interval. Advisors/Committee Members: Ayres, James W. (advisor).

Subjects/Keywords: Acetaminophen  – Bioavailability

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Hossain, M. (1991). Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation. (Doctoral Dissertation). Oregon State University. Retrieved from http://hdl.handle.net/1957/37368

Chicago Manual of Style (16th Edition):

Hossain, Mohammad. “Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation.” 1991. Doctoral Dissertation, Oregon State University. Accessed June 20, 2019. http://hdl.handle.net/1957/37368.

MLA Handbook (7th Edition):

Hossain, Mohammad. “Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation.” 1991. Web. 20 Jun 2019.

Vancouver:

Hossain M. Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation. [Internet] [Doctoral dissertation]. Oregon State University; 1991. [cited 2019 Jun 20]. Available from: http://hdl.handle.net/1957/37368.

Council of Science Editors:

Hossain M. Evaluation of gastrointestinal transit time and novel oral acetaminophen product formulation. [Doctoral Dissertation]. Oregon State University; 1991. Available from: http://hdl.handle.net/1957/37368


Rhodes University

3. Braae, Karen. The comparative bioavailability and in vitro assessment of solid oral dosage forms of paracetamol.

Degree: Faculty of Pharmacy, Pharmacy, 1981, Rhodes University

The dissolution profiles of eight lots of paracetamol tablets representing seven different tablet brands are determined in a USP rotating basket assembly and a stationary basket-rotating paddle apparatus. The in vitro data are expressed in terms of dissolution parameters and inter-tablet differences are assessed statistically using analysis of variance (ANOVA) and the Scheffe test. Highly significant differences are observed between a number of the tablets at the 95% confidence level. Representative tablets from the dissolution rate study and a control dose of paracetamol dissolved in water are subsequently investigated in a 4 x 4 latin square design bioavailability trial. Serum and urine samples are collected and assayed for paracetamol alone (serum) and together with its metabolites (urine) by means of high pressure liquid chromatography. The in vivo data are expressed in terms of bioavailability parameters and differences between the test doses are assessed by means of ANOVA. No significant differences are observed between the dosage forms at the 95% confidence level.

Subjects/Keywords: Acetaminophen; Bioavailability; Drugs  – Bioavailability; Drugs  – Dosage forms; Analysis of variance

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Braae, K. (1981). The comparative bioavailability and in vitro assessment of solid oral dosage forms of paracetamol. (Thesis). Rhodes University. Retrieved from http://hdl.handle.net/10962/d1006288

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Braae, Karen. “The comparative bioavailability and in vitro assessment of solid oral dosage forms of paracetamol.” 1981. Thesis, Rhodes University. Accessed June 20, 2019. http://hdl.handle.net/10962/d1006288.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Braae, Karen. “The comparative bioavailability and in vitro assessment of solid oral dosage forms of paracetamol.” 1981. Web. 20 Jun 2019.

Vancouver:

Braae K. The comparative bioavailability and in vitro assessment of solid oral dosage forms of paracetamol. [Internet] [Thesis]. Rhodes University; 1981. [cited 2019 Jun 20]. Available from: http://hdl.handle.net/10962/d1006288.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Braae K. The comparative bioavailability and in vitro assessment of solid oral dosage forms of paracetamol. [Thesis]. Rhodes University; 1981. Available from: http://hdl.handle.net/10962/d1006288

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

.