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You searched for subject:(Abdominoperineal excision). Showing records 1 – 2 of 2 total matches.

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University of Gothenburg / Göteborgs Universitet

1. Prytz, Mattias. Abdominoperineal excision for distal rectal carcinoma. Oncological outcome and aspects of self-assessed quality of life.

Degree: 2016, University of Gothenburg / Göteborgs Universitet

In recent years an adjusted method of performing an abdominoperineal excision (APE) - so called extralevator APE - has been developed and internationally spread. It has been proposed to decrease intraoperative perforations and non-radical surgery and therefor improve local cancer control and decrease rates of local recurrences as compared to standard APE. This thesis aims to investigate if the oncological outcome of ELAPE is superior to standard APE and to explore the association between patient reported intrusive thoughts and QoL as well as to type of surgery performed three years after surgery and to compare outcome to that found in a normative Swedish cohort. Data on all Swedish patients operated with any kind of APE in the years 2007-2009 were collected from the Swedish ColoRectal Cancer Registry and short-term oncological outcome was measured (i.e. perforations and non-radical surgery) as well as short-term complications and mortality. In order to be able to differ between APE and ELAPE, all patients’ operation notes were collected from the hospital charts where they had been operated, and analysed with regard to which operating technique had been used. When 3-years local recurrence data were available in the registry these data were also collected from the registry and analysed with regard to what operation had been performed. Furthermore, a special questionnaire was developed in order to be able to measure a number of health-related QoL parameters specific for this group of patients. The questionnaire was sent to all patients alive 3 years following surgery and data on QoL was compared to data from a Swedish normative population. Short-term oncological results were the same for both groups with regard to perforation and non-radical surgery. There were fewer intraoperative perforations for a subgroup of the most distal tumours in the ELAPE group but not for the entire group. There were more wound infections for the ELAPE-group. Local recurrences after 3 years were significantly more common in the ELAPE group as compared to standard APE but there was no difference between groups in overall survival. Intraoperative perforation was significantly associated with higher risk of local recurrence. A large proportion of survivors after abdominoperineal excision for rectal cancer have a quality of life comparable to a normative population, however many suffer from a symptom of stress, negative intrusive thoughts, which significantly decrease overall quality of life. Oncological outcome following ELAPE is not superior to standard APE. ELAPE is associated with more perineal wound complications. This method should be used in selected patients with high risk of intraoperative perforation.

Subjects/Keywords: Rectal cancer; Abdominoperineal excision; Extralevator Abdominoperineal excision

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Prytz, M. (2016). Abdominoperineal excision for distal rectal carcinoma. Oncological outcome and aspects of self-assessed quality of life. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/41842

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Prytz, Mattias. “Abdominoperineal excision for distal rectal carcinoma. Oncological outcome and aspects of self-assessed quality of life.” 2016. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed November 12, 2019. http://hdl.handle.net/2077/41842.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Prytz, Mattias. “Abdominoperineal excision for distal rectal carcinoma. Oncological outcome and aspects of self-assessed quality of life.” 2016. Web. 12 Nov 2019.

Vancouver:

Prytz M. Abdominoperineal excision for distal rectal carcinoma. Oncological outcome and aspects of self-assessed quality of life. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2016. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/2077/41842.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Prytz M. Abdominoperineal excision for distal rectal carcinoma. Oncological outcome and aspects of self-assessed quality of life. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2016. Available from: http://hdl.handle.net/2077/41842

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Gothenburg / Göteborgs Universitet

2. Asplund, Dan. Quality of life and morbidity in patients with rectal cancer.

Degree: 2016, University of Gothenburg / Göteborgs Universitet

Aim: The aim of this thesis was to investigate patient-reported and clinical outcome in patients with rectal cancer with specific focus on treatment-associated morbidity and quality of life. Method: Three clinical studies were conducted: a prospective multicentre cohort study, a retrospective case series and a nationwide cross-sectional questionnaire survey. In addition, population normative data on quality of life were obtained. Two study-specific questionnaires were developed and validated. Clinical data were collected from medical records and national quality registries. Results: Cancer-related intrusive thoughts, a possibly treatable stress-related symptom, independently predicted pretreatment quality of life in patients with a newly diagnosed rectal cancer (paper I-II). Extralevator abdominoperineal excision was associated with an increased rate of perineal wound complications compared with the conventional technique but oncological outcome was no better (paper III). Three years after surgery 50 % of responding patients experienced perineal symptoms and impaired postoperative wound healing emerged as a risk factor (paper IV). Conclusion: Psychological factors should be considered as relevant confounders in relation to quality of life in clinical studies. Efforts to decrease perineal wound complications following abdominoperineal excision are important, as complications may increase the risk for chronic perineal symptoms. Such symptoms are common three years after abdominoperineal excision.

Subjects/Keywords: Rectal cancer; Quality of life; Morbidity; Abdominoperineal excision; Intrusive thoughts; Sense of coherence; Chronic perineal symptoms

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Asplund, D. (2016). Quality of life and morbidity in patients with rectal cancer. (Thesis). University of Gothenburg / Göteborgs Universitet. Retrieved from http://hdl.handle.net/2077/44857

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Asplund, Dan. “Quality of life and morbidity in patients with rectal cancer.” 2016. Thesis, University of Gothenburg / Göteborgs Universitet. Accessed November 12, 2019. http://hdl.handle.net/2077/44857.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Asplund, Dan. “Quality of life and morbidity in patients with rectal cancer.” 2016. Web. 12 Nov 2019.

Vancouver:

Asplund D. Quality of life and morbidity in patients with rectal cancer. [Internet] [Thesis]. University of Gothenburg / Göteborgs Universitet; 2016. [cited 2019 Nov 12]. Available from: http://hdl.handle.net/2077/44857.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Asplund D. Quality of life and morbidity in patients with rectal cancer. [Thesis]. University of Gothenburg / Göteborgs Universitet; 2016. Available from: http://hdl.handle.net/2077/44857

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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