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You searched for subject:(AZDU). Showing records 1 – 2 of 2 total matches.

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University of Georgia

1. Kong, Linghui. Preclinical pharmacokinetic studies of 3'-azido-2',3'-dideoxyuridine and its novel prodrugs.

Degree: 2014, University of Georgia

3'-Azido-2',3'-dideoxyuridine (AZDU, AzddU, CS-87, Uravidine) is a nucleoside analog with a similar chemical structure to 3'-azido-3'-deoxythymidine (AZT, zidovudine), the most frequently used drug in the treatment of HIV-infected patients. AZDU has been found to have potent anti-HIV activity in human peripheral blood mononuclear cells with significantly reduced human bone marrow toxicity, 30-fold less than AZT. Nevertheless, the potential of AZDU as a promising anti-HIV agent has been limited by its relatively short half-life, relatively low bioavailabilities as illustrated in various animal models as well as its extensive glucuronidation in HIV-infected patients. | As means of improving its pharmacokinetic profile, several novel compounds were synthesized as prodrugs of AZDU in order to obtain prolonged half-lives and good bioavailabilities. | Oral bioavailabilities of AZDU were determined in rats. A rapid, sensitive, reproducible high performance liquid chromatography (HPLC) method using gradient elution was developed to simultaneously quantitate AZDU and its prodrugs in rat plasma. Preclinical pharmacokinetic studies on one of the prodrugs, 3'-azido-2',3'- dideoxyuridine-5'-O-valinate hydrochloride, showed improved bioavailability of AZDU compared with that obtained after oral administration of the parent drug. Therefore, AZDU-VAL is a promising prodrug of AZDU. | 2'-Amino-6-cyclopropylamino-9-(2',3'-dideoxy-?-D-glycero-pent-2- enofuranosyl) purine (DV) was recently synthesized as a prodrug of the anti-HIV nucleoside analog 2', 3'-dideoxydidehydroguanine (D4G). In the present dissertation, a reliable, sensitive isocratic HPLC analytical method was developed to determine ADV in rat plasma and rat liver homogenates. This analytical method was employed in the bioconversion studies of ADV in vitro.

Subjects/Keywords: 3\'-AZIDO-2\',3\'-DIDEOXYURIDINE; AZDU; BIOAVAILABILITY; HPLC; PRODRUG; PHARMACOKINETICS; CYCLOPROPYL; GUANINE; BIOCONVERSION

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Kong, L. (2014). Preclinical pharmacokinetic studies of 3'-azido-2',3'-dideoxyuridine and its novel prodrugs. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/20223

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Kong, Linghui. “Preclinical pharmacokinetic studies of 3'-azido-2',3'-dideoxyuridine and its novel prodrugs.” 2014. Thesis, University of Georgia. Accessed April 14, 2021. http://hdl.handle.net/10724/20223.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Kong, Linghui. “Preclinical pharmacokinetic studies of 3'-azido-2',3'-dideoxyuridine and its novel prodrugs.” 2014. Web. 14 Apr 2021.

Vancouver:

Kong L. Preclinical pharmacokinetic studies of 3'-azido-2',3'-dideoxyuridine and its novel prodrugs. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Apr 14]. Available from: http://hdl.handle.net/10724/20223.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Kong L. Preclinical pharmacokinetic studies of 3'-azido-2',3'-dideoxyuridine and its novel prodrugs. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/20223

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation


University of Georgia

2. Clark, Teresa Nicole. Quantitative analysis and pharmacokinetics of reverse transcriptase inhibitors in the pregnant rat.

Degree: 2014, University of Georgia

For over two decades there has been a ceaseless search for more effective treatments of HIV/AIDS. Today there are a number of different therapies that fall into one of three categories, based on their mechanism of action. All currently marketed anti-HIV drugs are classified as either 1) nucleoside reverse transcriptase inhibitors, 2) non-nucleoside reverse transcriptase inhibitors, or 3) protease inhibitors. Each of these compounds has gone through FDA-regulated clinical trials to prove safety and efficacy. Due to a number of reasons, pregnant women are generally not used during clinical trials, so very little is known about the behavior of drugs during pregnancy. A pregnant rat model has been developed to investigate the pharmacokinetics and placental transport of drugs during pregnancy. Presented here are validated analytical methods for the extraction and quantitation of the nucleoside reverse transcriptase inhibitors azidouridine, didanosine and abacavir in the various matrices needed for maternal-fetal pharmacokinetic studies. Also presented here are the pharmacokinetics of two of these compounds, azidouridine (as compared to zidovudine) and abacavir, using a pregnant rat model.

Subjects/Keywords: Azidouridine; AZDU; Zidovudine; AZT; Abacavir; ABC; Didanosine; DDI; High Performance Liquid Chromatography; HPLC-UV; LC/MS/MS; Pharmacokinetics

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APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6th Edition):

Clark, T. N. (2014). Quantitative analysis and pharmacokinetics of reverse transcriptase inhibitors in the pregnant rat. (Thesis). University of Georgia. Retrieved from http://hdl.handle.net/10724/21009

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16th Edition):

Clark, Teresa Nicole. “Quantitative analysis and pharmacokinetics of reverse transcriptase inhibitors in the pregnant rat.” 2014. Thesis, University of Georgia. Accessed April 14, 2021. http://hdl.handle.net/10724/21009.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7th Edition):

Clark, Teresa Nicole. “Quantitative analysis and pharmacokinetics of reverse transcriptase inhibitors in the pregnant rat.” 2014. Web. 14 Apr 2021.

Vancouver:

Clark TN. Quantitative analysis and pharmacokinetics of reverse transcriptase inhibitors in the pregnant rat. [Internet] [Thesis]. University of Georgia; 2014. [cited 2021 Apr 14]. Available from: http://hdl.handle.net/10724/21009.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Clark TN. Quantitative analysis and pharmacokinetics of reverse transcriptase inhibitors in the pregnant rat. [Thesis]. University of Georgia; 2014. Available from: http://hdl.handle.net/10724/21009

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

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