subject:(ATOPIC DERMATITIS)

1. Drucker, Aaron Mark. Comorbidities of adult women with atopic dermatitis.

Degree: School of Public Health, 2017, Brown University

URL: https://repository.library.brown.edu/studio/item/bdr:733315/

► Atopic dermatitis (AD) is a chronically relapsing inflammatory disease that affects approximately 11% of US children and 7% of US adults. Although AD was previously… (more)

Subjects/Keywords: Atopic dermatitis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Drucker, A. M. (2017). Comorbidities of adult women with atopic dermatitis. (Thesis). Brown University. Retrieved from https://repository.library.brown.edu/studio/item/bdr:733315/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Drucker, Aaron Mark. “Comorbidities of adult women with atopic dermatitis.” 2017. Thesis, Brown University. Accessed January 18, 2021. https://repository.library.brown.edu/studio/item/bdr:733315/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Drucker, Aaron Mark. “Comorbidities of adult women with atopic dermatitis.” 2017. Web. 18 Jan 2021.

Vancouver:

Drucker AM. Comorbidities of adult women with atopic dermatitis. [Internet] [Thesis]. Brown University; 2017. [cited 2021 Jan 18]. Available from: https://repository.library.brown.edu/studio/item/bdr:733315/.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Drucker AM. Comorbidities of adult women with atopic dermatitis. [Thesis]. Brown University; 2017. Available from: https://repository.library.brown.edu/studio/item/bdr:733315/

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Johannesburg

2. Solomon, Michael William. Behavioural intervention in atopic dermatitis.

Degree: 2014, University of Johannesburg

URL: http://hdl.handle.net/10210/9600

►

M.A. (Clinical Psychology)

The purpose of this study was to determine whether a behavioural intervention could reduce scratching behaviour in atopic dermatitis. The literature dealing… (more)

Subjects/Keywords: Behavior therapy; Atopic dermatitis - Psychological aspects; Atopic dermatitis -Treatment - Research; Atopic dermatitis -Treatment - Case Studies

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Solomon, M. W. (2014). Behavioural intervention in atopic dermatitis. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/9600

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Solomon, Michael William. “Behavioural intervention in atopic dermatitis.” 2014. Thesis, University of Johannesburg. Accessed January 18, 2021. http://hdl.handle.net/10210/9600.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Solomon, Michael William. “Behavioural intervention in atopic dermatitis.” 2014. Web. 18 Jan 2021.

Vancouver:

Solomon MW. Behavioural intervention in atopic dermatitis. [Internet] [Thesis]. University of Johannesburg; 2014. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10210/9600.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Solomon MW. Behavioural intervention in atopic dermatitis. [Thesis]. University of Johannesburg; 2014. Available from: http://hdl.handle.net/10210/9600

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Tasmania

3. King, RM. Psychological aspects of atopic dermatitis.

Degree: 1993, University of Tasmania

URL: https://eprints.utas.edu.au/20286/1/whole_KingRossMcIvor1993_thesis.pdf

► Atopic dermatitis is a chronic fluctuating skin disease which usually has an onset between two and six months after birth. During exacerbations, the lesions become… (more)

▼ Atopic dermatitis is a chronic fluctuating skin disease which usually has an onset between two and six months after birth. During exacerbations, the lesions become widely disseminated; redness, oedema, weeping, crusting, excoriations, and fissures are the distinctive features. The pathogenesis of atopic dermatitis is not clearly understood. Genetic, environmental, physiological, immunological, and psychological factors have all been implicated. Emotional stress, personality structure, psychophysiological abnormalities, and learned behaviour have been advanced as mechanisms by which psychological factors affect atopic dermatitis. This thesis examines the first three of these areas. Retrospective interview studies have found that emotional stress precipitates exacerbations of atopic dermatitis in approximately 70% of cases but studies utilising life events and daily hassles as measures of stress have not found evidence of an association. In the first study reported of this thesis, 50 atopic dermatitis sufferers completed a daily diary for a fortnight, recording their emotional state and skin condition. Both self-report of interpersonal stress and depression were significantly related to changes in the skin condition. Lag sequential analyses indicated that interpersonal stress on Day X predicted skin condition on Day X+1 and that this relationship was reciprocal. The second study examined the relationship between stress and skin symptoms in 13 atopic dermatitis suffferers sitting university examinations. Again, a significantly positive relationship was found. A preliminary study of appraisal and coping processes associated with examinations was conducted utilising multiple regression analysis in order to determine their relationship to skin symptoms. The literature on the relationship between personality features and atopic dermatitis was reviewed and a meta-analysis of suitable studies conducted. Based on the results of this review and meta-analysis, a study was performed in which 50 atopic dermatitis sufferers recruited from the general community were compared to 20 subjects with ichthyosis; also from the community; and 35 skin disorder-free controls on a range of personality and emotional state measures. The atopic dermatitis sufferers were divided on the basis of whether subjects believed that stress affected their symptoms. The "nonstress" atopic dermatitis sufferers were found to score lower on neuroticism than all other groups. They also reported less trait anxiety, lower emotional dependence on others, and a more internal locus of control with regard to control over social systems than the "stress" atopic dermatitis sufferers. No other differences existed between the groups, with the exception of the fact that the ichthyosis sufferers were significantly more able to assert their autonomy, and less conforming in their responses to frustrating circumstances. However, the skin disorder control group was noted to have a higher level of neuroticism than published norms. The use of subjects recruited from the…

Subjects/Keywords: Atopic dermatitis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

King, R. (1993). Psychological aspects of atopic dermatitis. (Thesis). University of Tasmania. Retrieved from https://eprints.utas.edu.au/20286/1/whole_KingRossMcIvor1993_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

King, RM. “Psychological aspects of atopic dermatitis.” 1993. Thesis, University of Tasmania. Accessed January 18, 2021. https://eprints.utas.edu.au/20286/1/whole_KingRossMcIvor1993_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

King, RM. “Psychological aspects of atopic dermatitis.” 1993. Web. 18 Jan 2021.

Vancouver:

King R. Psychological aspects of atopic dermatitis. [Internet] [Thesis]. University of Tasmania; 1993. [cited 2021 Jan 18]. Available from: https://eprints.utas.edu.au/20286/1/whole_KingRossMcIvor1993_thesis.pdf.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

King R. Psychological aspects of atopic dermatitis. [Thesis]. University of Tasmania; 1993. Available from: https://eprints.utas.edu.au/20286/1/whole_KingRossMcIvor1993_thesis.pdf

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Debrecen

4. Kashani, Shirin. Formulations and investigations of different topical preparations for the treatment of eczéma .

Degree: DE – Gyógyszerésztudományi Kar, University of Debrecen

URL: http://hdl.handle.net/2437/228239

► As Eczema Is the most common disorder nowadays,without actual treatment;Therefore I've decided to compare seven different creams based on: dosage of their active ingredients and… (more)

Subjects/Keywords: Atopic Dermatitis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kashani, S. (n.d.). Formulations and investigations of different topical preparations for the treatment of eczéma . (Thesis). University of Debrecen. Retrieved from http://hdl.handle.net/2437/228239

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Kashani, Shirin. “Formulations and investigations of different topical preparations for the treatment of eczéma .” Thesis, University of Debrecen. Accessed January 18, 2021. http://hdl.handle.net/2437/228239.

Note: this citation may be lacking information needed for this citation format:
No year of publication.
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Kashani, Shirin. “Formulations and investigations of different topical preparations for the treatment of eczéma .” Web. 18 Jan 2021.

Note: this citation may be lacking information needed for this citation format:
No year of publication.

Vancouver:

Kashani S. Formulations and investigations of different topical preparations for the treatment of eczéma . [Internet] [Thesis]. University of Debrecen; [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2437/228239.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

Council of Science Editors:

Kashani S. Formulations and investigations of different topical preparations for the treatment of eczéma . [Thesis]. University of Debrecen; Available from: http://hdl.handle.net/2437/228239

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation
No year of publication.

University of Dundee

5. Brown, Sara Judith. Molecular and genetic mechanisms in atopic eczema.

Degree: PhD, 2020, University of Dundee

URL: https://discovery.dundee.ac.uk/en/studentTheses/941cdc3b-24af-4b86-a772-d7ac4a6f2347 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.818452

► Atopic eczema is a common, complex trait that is highly heritable. This thesis describes a body of research over 5 years, from 2014 to 2019,… (more)

▼ Atopic eczema is a common, complex trait that is highly heritable. This thesis describes a body of research over 5 years, from 2014 to 2019, highlighting six key publications. These are described on a background of intense activity within the fieldof atopic eczema genetic research, stimulated by the discovery, in 2006, of loss-of-function mutations in the gene encoding filaggrin (FLG). FLG null mutations play a major role in eczema and other atopic diseases and my work has built on this seminal discovery. I described, for the first time, transcriptomic features of FLG haploinsufficiency (Cole et al. J Allergy Clin Immunol 2014). I tested the effect ofFLG null mutations on the skin’s response to ultraviolet-induced erythema in vivo(Forbes et al. J Allergy Clin Immunol 2016). I optimised a well-established organoid model, using primary human keratinocytes and fibroblasts to recapitulate aspects of human skin for functional testing of specific genetic effects. Quantitative global proteomic analysis of the organoid model with FLG knockdown has replicated findings from previous transcriptome analyses and showed evidence of keratinocyte-immune cell cross-talk and disordered axon guidance (Elias et al. Wellcome Open Research 2019). Detailed analysis of the organoid model with knockdown of thetranscriptional repressor EMSY has shown, for the first time, that this protein is a master-regulator of multiple aspects of skin barrier formation (Elias et al. J Allergy Clin Immunol 2019). Taking a statistical approach driven by a clinical question, longitudinal latent class analysis applied to two independent populations identified distinct subgroups of eczema (Paternoster et al. J Allergy Clin Immunol 2018) in which the most long-lasting phenotypes show the greatest genetic risk, including FLG null genotype. Finally, leveraging the similarities and differences between eczema and psoriasis, a genome-wide comparative analysis identified opposing genetic mechanisms in these common inflammatory skin diseases (Baurecht et al. Am J Hum Genet 2015) providing a theoretical rationale for therapies designed to rebalance the skin’s tendency to atopic versus psoriatic inflammation. Together this body of work has substantially increased understanding of genetic mechanisms in atopic skin, with important clinical applications and opportunities for much-needed therapeutic development.

Subjects/Keywords: Atopic; Eczema; Dermatitis; Genetics; Dermatology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Brown, S. J. (2020). Molecular and genetic mechanisms in atopic eczema. (Doctoral Dissertation). University of Dundee. Retrieved from https://discovery.dundee.ac.uk/en/studentTheses/941cdc3b-24af-4b86-a772-d7ac4a6f2347 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.818452

Chicago Manual of Style (16^th Edition):

Brown, Sara Judith. “Molecular and genetic mechanisms in atopic eczema.” 2020. Doctoral Dissertation, University of Dundee. Accessed January 18, 2021. https://discovery.dundee.ac.uk/en/studentTheses/941cdc3b-24af-4b86-a772-d7ac4a6f2347 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.818452.

MLA Handbook (7^th Edition):

Brown, Sara Judith. “Molecular and genetic mechanisms in atopic eczema.” 2020. Web. 18 Jan 2021.

Vancouver:

Brown SJ. Molecular and genetic mechanisms in atopic eczema. [Internet] [Doctoral dissertation]. University of Dundee; 2020. [cited 2021 Jan 18]. Available from: https://discovery.dundee.ac.uk/en/studentTheses/941cdc3b-24af-4b86-a772-d7ac4a6f2347 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.818452.

Council of Science Editors:

Brown SJ. Molecular and genetic mechanisms in atopic eczema. [Doctoral Dissertation]. University of Dundee; 2020. Available from: https://discovery.dundee.ac.uk/en/studentTheses/941cdc3b-24af-4b86-a772-d7ac4a6f2347 ; https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.818452

University of Hong Kong

6. Wong, Siu-leung. The evidence-based guideline of nursing consultation session for children with atopic dermatitis.

Degree: 2013, University of Hong Kong

URL: http://hdl.handle.net/10722/193085

► Atopic dermatitis (AD) is one of the most common chronic dermatological diseases. It has affected up to a fifth of schoolchildren and their caregivers. It… (more)

▼ Atopic dermatitis (AD) is one of the most common chronic dermatological diseases. It has affected up to a fifth of schoolchildren and their caregivers. It will alter not only children’s physical health, but also worsen the quality of life among children and their family. This global public health problem also increased the financial and social burden to healthcare system in the past decades. Educational intervention has been proved to be an adjunct to current treatment to restore the altered quality of life and skin condition effectively. It could be simply carried out by trained nurses in the routine practice to educate patients about proper AD management. However, such intervention is seldom mentioned in the local setting. Therefore, it is essential to establish an effective evidence-based guideline of nursing consultation in order to enhance patients’ clinical outcomes. The objectives of this study are to search and synthesize current literatures systematically in educational interventions for AD children for reducing disease severity and improving quality of life, to assess the implementation potential of identified educational interventions, to develop an evidence-based guideline of nursing consultation for providing better skin care to the AD children and to develop the implementation and evaluation plan the proposed intervention. Nursing consultation session for AD children is proposed in this study. The target population and setting are AD children aged from 4-16 years attending to one of the local public dermatological outpatient clinics. Evidence and relevant data are yielded from eight high-quality studies. The potential of implementing the proposed intervention is assessed based on the transferability of the findings, feasibility and the cost-benefit ratio. An evidence-based guideline is eventually developed with the best evidence-based findings. At last, an implementation plan and evaluation plan for the proposed guideline are well designed. This evidence-based guideline is designed to improve the quality of life and reduce the severity of skin condition of AD children. It is recommended to establish to all dermatological outpatient clinics locally.

Subjects/Keywords: Atopic dermatitis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wong, S. (2013). The evidence-based guideline of nursing consultation session for children with atopic dermatitis. (Thesis). University of Hong Kong. Retrieved from http://hdl.handle.net/10722/193085

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wong, Siu-leung. “The evidence-based guideline of nursing consultation session for children with atopic dermatitis.” 2013. Thesis, University of Hong Kong. Accessed January 18, 2021. http://hdl.handle.net/10722/193085.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wong, Siu-leung. “The evidence-based guideline of nursing consultation session for children with atopic dermatitis.” 2013. Web. 18 Jan 2021.

Vancouver:

Wong S. The evidence-based guideline of nursing consultation session for children with atopic dermatitis. [Internet] [Thesis]. University of Hong Kong; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10722/193085.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wong S. The evidence-based guideline of nursing consultation session for children with atopic dermatitis. [Thesis]. University of Hong Kong; 2013. Available from: http://hdl.handle.net/10722/193085

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

IUPUI

7. DaSilva, Sonia Cristina. Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation.

Degree: 2011, IUPUI

URL: http://hdl.handle.net/1805/2488

►

Indiana University-Purdue University Indianapolis (IUPUI)

Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease with a lifetime prevalence of 10-20% in children and 1-3%… (more)

Subjects/Keywords: STAT6VT transgenic mice Atopic Dermatitis; Atopic dermatitis – Research; T cells

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

DaSilva, S. C. (2011). Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation. (Thesis). IUPUI. Retrieved from http://hdl.handle.net/1805/2488

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

DaSilva, Sonia Cristina. “Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation.” 2011. Thesis, IUPUI. Accessed January 18, 2021. http://hdl.handle.net/1805/2488.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

DaSilva, Sonia Cristina. “Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation.” 2011. Web. 18 Jan 2021.

Vancouver:

DaSilva SC. Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation. [Internet] [Thesis]. IUPUI; 2011. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1805/2488.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

DaSilva SC. Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation. [Thesis]. IUPUI; 2011. Available from: http://hdl.handle.net/1805/2488

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

NSYSU

8. Wu, Meng-shan. The effects of anti-inflammatory marine compound on dermatology disorders.

Degree: Master, Marine Biotechnology and Resources, 2016, NSYSU

URL: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0223116-110613

► Skin is a mechanical and a chemical barrier against the invasion of pathogens. In addition, skin also plays an important role in the secretion, temperature… (more)

Subjects/Keywords: Burn; Anti-inflammatory; Angiogenesis; Atopic dermatitis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wu, M. (2016). The effects of anti-inflammatory marine compound on dermatology disorders. (Thesis). NSYSU. Retrieved from http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0223116-110613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Wu, Meng-shan. “The effects of anti-inflammatory marine compound on dermatology disorders.” 2016. Thesis, NSYSU. Accessed January 18, 2021. http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0223116-110613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Wu, Meng-shan. “The effects of anti-inflammatory marine compound on dermatology disorders.” 2016. Web. 18 Jan 2021.

Vancouver:

Wu M. The effects of anti-inflammatory marine compound on dermatology disorders. [Internet] [Thesis]. NSYSU; 2016. [cited 2021 Jan 18]. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0223116-110613.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Wu M. The effects of anti-inflammatory marine compound on dermatology disorders. [Thesis]. NSYSU; 2016. Available from: http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0223116-110613

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Universiteit Utrecht

9. Wijngaarden, J.H. Tissue factors are disease determinants in allergy.

Degree: 2013, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/282642

► Over 40% of the western population is atopic however, only a limited percentage develops allergic disease. Many chromosomal loci containing immune related genes have been… (more)

▼ Over 40% of the western population is atopic however, only a limited percentage develops allergic disease. Many chromosomal loci containing immune related genes have been associated with allergic disease, but immune dysregulation alone cannot explain disease development. In recent years the contribution of tissue restricted factors to development of allergic disease has become a research focus. The skin and the airway epithelium are highly structured barriers as the first line of defense against allergen entry and sensitization. Keratinocytes and epithelial cells are also now recognized to play a driving role in allergic inflammation. Epidermal barrier breakdown due to genetic polymorphisms and/or environmental factors can lead to the development of atopic dermatitis (AD). Genetic polymorphisms in filaggrin, a key component of the stratum corenum and lipid lamellae barriers of the skin, are associated with a higher risk of AD. Dysregulation of desquamation due to Kallikrein-related peptidase-7, Lymphoepithelial Kazal-type-related inhibitor and cystatin A polymorphisms and breakdown of the tight junction barrier due to claudin-1 polymorphisms are also associated with AD. Airway epithelial barrier integrity is essential in protection against asthma development. This barrier depends on cell-cell adhesion, primarily through tight and adherens junctions. Many adhesive proteins including claudin-1, occludin, zonula occludens-1, e-cadherin, α-catenin and protocadherin-1 have been associated with asthma development. Airway remodelling, a common feature of asthma, was believed to be caused by chronic airway inflammation in the asthmatic lung; however there are recent indications that it also has a genetic component. ADAM33 and claudin-1 have been associated with airway remodelling. With the evidence that tissue dysregulation is at the base of allergic disease, therapeutic approaches have shifted to address the underlying tissue irregularities rather than simply suppressing inflammation. This shift opens the door for development of preventative therapies. Advisors/Committee Members: Knol, E.

Subjects/Keywords: Asthma; Atopic dermatitis; Tissue factors; Filaggrin; ADAM33

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wijngaarden, J. H. (2013). Tissue factors are disease determinants in allergy. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/282642

Chicago Manual of Style (16^th Edition):

Wijngaarden, J H. “Tissue factors are disease determinants in allergy.” 2013. Masters Thesis, Universiteit Utrecht. Accessed January 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/282642.

MLA Handbook (7^th Edition):

Wijngaarden, J H. “Tissue factors are disease determinants in allergy.” 2013. Web. 18 Jan 2021.

Vancouver:

Wijngaarden JH. Tissue factors are disease determinants in allergy. [Internet] [Masters thesis]. Universiteit Utrecht; 2013. [cited 2021 Jan 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/282642.

Council of Science Editors:

Wijngaarden JH. Tissue factors are disease determinants in allergy. [Masters Thesis]. Universiteit Utrecht; 2013. Available from: http://dspace.library.uu.nl:8080/handle/1874/282642

University of Rochester

10. Kuo, I-Hsin. Activation of Epidermal Toll-like Receptor 2 Enhances Tight Junction Function:Implications for Atopic Dermatitis and Skin Barrier Repair.

Degree: PhD, 2013, University of Rochester

URL: http://hdl.handle.net/1802/27274

► Atopic dermatitis (AD) is a Th2-skewed, allergen-driven skin disease characterized by epidermal tight junction (TJ) defects and a propensity for Staphylococcus aureus (S. aureus) skin… (more)

▼ Atopic dermatitis (AD) is a Th2-skewed, allergen-driven skin disease characterized by epidermal tight junction (TJ) defects and a propensity for Staphylococcus aureus (S. aureus) skin infections. One widely held hypothesis is that the leaky epithelial barrier promotes immunologic responsiveness to allergens through the skin. Toll-like receptor (TLR) 2, a key innate receptor responsive to S. aureus, was originally recognized for its antimicrobial actions, but recently it has been shown to regulate intestinal epithelial barrier. We hypothesized that an effective cutaneous innate immune response might also include skin barrier repair. Furthermore, this barrier repair response may be impaired in AD patients. To determine the importance of TLR2 in epidermal barrier function, we used primary human keratinocytes (PHK), discarded human skins and Tlr2-/- mice. The TLR2 agonist increased TJ protein expression and function in PHK and enhanced TJ barrier repair in a murine wound model that mimics the itch-scratch cycle observed in AD patients. Since AD is a Th2-polarized inflammatory disorder, we hypothesized that Th2 cytokines might impair this TLR2-mediated barrier repair function. Th2 cytokines decreased TLR2 protein expression and attenuated TLR2’s barrier repair function in PHK and human epidermis. STAT6VT mice with a hyper-Th2 immune profile had reduced epidermal TLR2 protein expression and impaired TJ barrier recovery in response to TLR2 agonist. Bringing this observation back to human AD, we observed that epidermal TLR2 protein immunoreactivity was significantly reduced in nonlesional and lesional AD skin as compared to nonatopic controls (NA). The intensity of the TLR2 staining inversely correlated with skin barrier integrity and two Th2 biomarkers (serum total IgE levels and circulating eosinophil counts). In summary, TLR2 activation enhances TJ barrier in murine and human epidermis and is an important part of an epidermal wound repair response. Th2 cytokines commonly found in AD skin reduce epidermal TLR2 expression and barrier repair function. Our findings strongly suggest that antagonizing Th2 cytokines in AD patients may restore TLR2-mediated innate immune responses, which will help repair epidermal barrier defects and possibly also eliminate unwanted cutaneous pathogens.

Subjects/Keywords: TLR2; Tight Junction; Atopic Dermatitis; Keratinocyte

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Kuo, I. (2013). Activation of Epidermal Toll-like Receptor 2 Enhances Tight Junction Function:Implications for Atopic Dermatitis and Skin Barrier Repair. (Doctoral Dissertation). University of Rochester. Retrieved from http://hdl.handle.net/1802/27274

Chicago Manual of Style (16^th Edition):

Kuo, I-Hsin. “Activation of Epidermal Toll-like Receptor 2 Enhances Tight Junction Function:Implications for Atopic Dermatitis and Skin Barrier Repair.” 2013. Doctoral Dissertation, University of Rochester. Accessed January 18, 2021. http://hdl.handle.net/1802/27274.

MLA Handbook (7^th Edition):

Kuo, I-Hsin. “Activation of Epidermal Toll-like Receptor 2 Enhances Tight Junction Function:Implications for Atopic Dermatitis and Skin Barrier Repair.” 2013. Web. 18 Jan 2021.

Vancouver:

Kuo I. Activation of Epidermal Toll-like Receptor 2 Enhances Tight Junction Function:Implications for Atopic Dermatitis and Skin Barrier Repair. [Internet] [Doctoral dissertation]. University of Rochester; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1802/27274.

Council of Science Editors:

Kuo I. Activation of Epidermal Toll-like Receptor 2 Enhances Tight Junction Function:Implications for Atopic Dermatitis and Skin Barrier Repair. [Doctoral Dissertation]. University of Rochester; 2013. Available from: http://hdl.handle.net/1802/27274

University of Johannesburg

11. Olivier, Yolande. The effect of a homoeopathic complex on atopic dermatitis in children.

Degree: 2013, University of Johannesburg

URL: http://hdl.handle.net/10210/8324

►

M.Tech. (Homoeopathy)

Atopic dermatitis (atopic eczema) is a chronic, relapsing, allergic inflammatory skin disease (Hauk, 2008). The prevalence of atopic dermatitis has increased significantly over… (more)

▼

M.Tech. (Homoeopathy)

Atopic dermatitis (atopic eczema) is a chronic, relapsing, allergic inflammatory skin disease (Hauk, 2008). The prevalence of atopic dermatitis has increased significantly over the past few decades, with highest rates of 45 – 64% occurring amongst preschool children (Butler, 2009), and 40% amongst older children and adults (Manjra, 2005). This increase in prevalence is attributed to environmental factors such as microbial exposure and poor nutrition, which can all lead to atopic dermatitis (Schnopp, 2006). The quality of life of patients suffering from atopic dermatitis and their family members are significantly affected (Manjra, 2005). Atopic dermatitis is characterized by active skin lesions that are red, flaky, dry and itchy and in children commonly occurs in the flexural areas of the body (Fölster-Hols et al., 2007, Schnopp, 2006). Conventional treatment potions for atopic dermatitis are associated with adverse effects in children (Kalicharan et al., 2005). Homoeopathic remedies may offer an alternative option for this condition. This study aimed to assess the effect of a homoeopathic complex consisting of Graphites 6cH, Histaminum 9cH, Psorinum 6cH and Sulphur 6cH, on atopic dermatitis in children. All the participants of the study received the homoeopathic complex. The atopic dermatitis was evaluated using the SCORAD index (Scoring of Atopic Dermatitis) (Appendix F) and the Children’s Dermatology Life Quality Index (CDLQI) (Appendix E). Thirty four participants who met the inclusion and exclusion criteria were recruited to participate in this pre-test – post-test single group study by means of advertisements (Appendix A) placed in and around primary schools in the Gauteng area (with relevant permission given) and in the local newspaper. Participants were also recruited via word of mouth. Once participants were accepted into the study they were allocated into the treatment group which received the homoeopathic complex containing Graphites 6cH, Histaminum 9cH, Psorinum 6cH and Sulphur 6cH. The study was completed over a four week period. The percentage of the area affected, the intensity of the symptoms, the pruritus and the loss of sleep as well as the quality of life of the participants suffering from atopic dermatitis were aspects of the condition evaluated on a weekly basis. The results for the CDLQI showed improvements in the participant’s perception of itching/ pain of the affected area, as well as their quality of sleep. These improvements were shown to have occurred gradually over the study period. There were however no statistically significant changes noted in the mental and emotional quality of life of the participants.

Subjects/Keywords: Atopic dermatitis - Homeopathic treatment; Pediatric dermatology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Olivier, Y. (2013). The effect of a homoeopathic complex on atopic dermatitis in children. (Thesis). University of Johannesburg. Retrieved from http://hdl.handle.net/10210/8324

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Olivier, Yolande. “The effect of a homoeopathic complex on atopic dermatitis in children.” 2013. Thesis, University of Johannesburg. Accessed January 18, 2021. http://hdl.handle.net/10210/8324.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Olivier, Yolande. “The effect of a homoeopathic complex on atopic dermatitis in children.” 2013. Web. 18 Jan 2021.

Vancouver:

Olivier Y. The effect of a homoeopathic complex on atopic dermatitis in children. [Internet] [Thesis]. University of Johannesburg; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10210/8324.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Olivier Y. The effect of a homoeopathic complex on atopic dermatitis in children. [Thesis]. University of Johannesburg; 2013. Available from: http://hdl.handle.net/10210/8324

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of California – San Francisco

12. Dembo, Todd Michael. Molecular and genetic studies of pain and itch.

Degree: Neuroscience, 2017, University of California – San Francisco

URL: http://www.escholarship.org/uc/item/79g3p6wn

► Chronic pain and itch pose ever present, steadily growing burdens to human health. Still, we have limited understanding of the mechanisms that underlie their development… (more)

▼ Chronic pain and itch pose ever present, steadily growing burdens to human health. Still, we have limited understanding of the mechanisms that underlie their development and persistence. Furthermore, treatments for these conditions tend to be palliative, rather than curative, leading to mixed patient outcomes. With this in mind, we used next generation sequencing to assemble a transcriptional profile of the molecular changes in skin and sensory neurons that associate with a unique, stochastic mouse model of atopic dermatitis. This model combines the genetic sensitization of a PAR2 overexpression animal with environmental challenge by house dust mite allergens. To our knowledge, this is the first profiling effort that broadened its focus beyond the skin to look at the important, itch-facilitating contribution of sensory neurons. An interesting feature of this PAR2 model is that, by virtue of its stochasticity, it may allow for the independent identification of both protective and deleterious changes. These datasets will serve as useful resources for clinicians and researchers interested in the pathogenesis and prevention of atopic dermatitis. Among the many genetic changes detected in our analysis was brain-derived neurotrophic factor (BDNF), which is expressed by sensory neurons and has been repeatedly implicated in different pain and itch conditions. Thus, in a parallel series of studies, we investigated the neuronal expression pattern and behavioral contributions of primary afferent-derived BDNF. Contrary to previous reports, we found that BDNF expression within dorsal root ganglia predominates in large-diameter, myelinated neurons. Furthermore, we found little evidence that BDNF contributes significantly to acute or chronic pain, with one notable exception observed in the formalin test of inflammatory pain. The selective deletion of BDNF from primary sensory neurons markedly reduced nocifensive behaviors during the second phase of the formalin test, which is thought to model tissue injury-induced post-operative pain. Surprisingly, this difference was sexually dimorphic, and only occurred in male mice. However, based on its expression pattern within sensory ganglia and its minimal apparent contribution to pain or itch, we suggest that, in the future, primary afferent-derived BDNF should be studied in the context of low-threshold mechanotransduction.

Subjects/Keywords: Neurosciences; Atopic dermatitis; BDNF; Itch; Pain

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Dembo, T. M. (2017). Molecular and genetic studies of pain and itch. (Thesis). University of California – San Francisco. Retrieved from http://www.escholarship.org/uc/item/79g3p6wn

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Dembo, Todd Michael. “Molecular and genetic studies of pain and itch.” 2017. Thesis, University of California – San Francisco. Accessed January 18, 2021. http://www.escholarship.org/uc/item/79g3p6wn.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Dembo, Todd Michael. “Molecular and genetic studies of pain and itch.” 2017. Web. 18 Jan 2021.

Vancouver:

Dembo TM. Molecular and genetic studies of pain and itch. [Internet] [Thesis]. University of California – San Francisco; 2017. [cited 2021 Jan 18]. Available from: http://www.escholarship.org/uc/item/79g3p6wn.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Dembo TM. Molecular and genetic studies of pain and itch. [Thesis]. University of California – San Francisco; 2017. Available from: http://www.escholarship.org/uc/item/79g3p6wn

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Edinburgh

13. Tan, Siao Pei. Improving the skin barrier function in atopic dermatitis.

Degree: PhD, 2013, University of Edinburgh

URL: http://hdl.handle.net/1842/11735

► Atopic dermatitis, AD (synonym eczema) is a chronic inflammatory skin disease. It affects between 10 to 20% of children and 1 to 3% of adults… (more)

▼ Atopic dermatitis, AD (synonym eczema) is a chronic inflammatory skin disease. It affects between 10 to 20% of children and 1 to 3% of adults worldwide. It is an important cause of morbidity and is estimated to cost £465 million per annum to the UK. AD is part of a family of Th-2 driven diseases and is often the first of these atopic diseases to manifest. The development of AD is often followed by asthma and allergic rhinitis later in life (a phenomenon known as the ‘atopic march’). Up to 50% of moderate to severe AD cases have been associated with genetic mutations affecting the epidermal barrier protein filaggrin. Filaggrin aggregates keratin filaments during terminal keratinocyte differentiation, allowing normal epidermal stratification. The role of filaggrin in maintaining a functional skin barrier is further supported by a clinical study conducted by ourselves. This is the first clinical study on a European cohort (58 participants) which showed that FLG mutations were associated with experimentally demonstrable defects of skin barrier function (increased baseline transepidermal water loss), more so following exposure to a chemical irritant. However, the majority of patients with AD, especially the milder cases, do not have FLG mutations. Some of the wild-type patients in our study were noticed to have accumulation of the large filaggrin proprotein and a lack of filaggrin monomers, indicating defective proteolysis of profilaggrin into the functional monomers. Our study also found disproportionately raised protease inhibitory activities amongst the AD participants. This inappropriately raised protease inhibition may interfere with profilaggrin proteolysis, leading to the development of AD in some wild-type patients. Having demonstrated that deficiency of filaggrin monomers is associated with a defective skin barrier, we focused on the function of filaggrin in the skin and attempted to improve the skin barrier function. In addition to keratin aggregation, filaggrin constitutes the natural moisturizing factors in the epidermis following its natural breakdown into amino acids. We note that filaggrin is disproportionately rich in amino acid histidine, implying that this amino acid may have a particular significance in maintaining a functional epidermal barrier. Using an in-house skin-equivalent model, we have shown that by increasing the histidine content in the cell culture media, we could increase the expression of filaggrin monomers and reduce the penetration of a fluorescent dye into the skin-equivalents. The latter indicates improved barrier function. Finally, we conducted a pilot human study which showed that histidine, when applied to mechanically damaged skin in AD and healthy participants, was associated with a faster recovery of the skin barrier function. These studies suggest that histidine is of therapeutic benefits in AD. A histidine-based treatment may be developed as an alternative to current anti-inflammatory and immunosuppressive agents used to treat AD.

Subjects/Keywords: 616.5; skin barrier function; atopic dermatitis; eczema

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tan, S. P. (2013). Improving the skin barrier function in atopic dermatitis. (Doctoral Dissertation). University of Edinburgh. Retrieved from http://hdl.handle.net/1842/11735

Chicago Manual of Style (16^th Edition):

Tan, Siao Pei. “Improving the skin barrier function in atopic dermatitis.” 2013. Doctoral Dissertation, University of Edinburgh. Accessed January 18, 2021. http://hdl.handle.net/1842/11735.

MLA Handbook (7^th Edition):

Tan, Siao Pei. “Improving the skin barrier function in atopic dermatitis.” 2013. Web. 18 Jan 2021.

Vancouver:

Tan SP. Improving the skin barrier function in atopic dermatitis. [Internet] [Doctoral dissertation]. University of Edinburgh; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1842/11735.

Council of Science Editors:

Tan SP. Improving the skin barrier function in atopic dermatitis. [Doctoral Dissertation]. University of Edinburgh; 2013. Available from: http://hdl.handle.net/1842/11735

14. TOWELL, AISLING. Investigating factors that contribute to the ability of Staphylococcus aureus to colonise atopic dermatitis skin.

Degree: School of Genetics & Microbiology. Discipline of Microbiology, 2019, Trinity College Dublin

URL: http://hdl.handle.net/2262/89186

► The skin of atopic dermatitis (AD) patients is frequently colonised by Staphylococcus aureus. Colonisation by S. aureus correlates with disease severity and exacerbated disease symptoms.… (more)

▼ The skin of atopic dermatitis (AD) patients is frequently colonised by Staphylococcus aureus. Colonisation by S. aureus correlates with disease severity and exacerbated disease symptoms. The factors involved in S. aureus colonisation of AD skin have not been fully described. This thesis aimed to identify molecular determinants contributing to the colonisation of AD skin by S. aureus. A skin protein corneodesmosin (CDSN) is abnormally displaced in AD skin and is potentially more accessible to bacteria. Here, CDSN was identified as a novel ligand for S. aureus. A plasmid expressing GST-tagged recombinant CDSN (rCDSN) was constructed and rCDSN was purified from bacteria. Allelic exchange was used to construct mutants of a clinically relevant AD strain AD08, deficient in ClfB and/or FnBPA and/or FnBPB to examine the role of these proteins. AD08 did not adhere to CDSN in the absence of ClfB and FnBPB indicating that these two proteins promote adherence to CDSN. Measuring S. aureus adherence to corneocytes isolated from AD patients showed that ClfB, FnBPA and/or FnBPB facilitate attachment to AD corneocytes. The S. aureus binding site in CDSN was mapped to the N-terminal omega loop region and blocking this region with anti- CDSN antibody raised against the N-terminus of CDSN reduced S. aureus adherence to AD corneocytes implying that S. aureus targets CDSN to adhere to AD corneocytes. Having shown that FnBPA and FnBPB bind to CDSN in vitro, the ability of these proteins to support bacterial adhesion to loricrin and cytokeratin 10 (K10) was examined. Both proteins are established ligands for ClfB however this study showed that S. aureus mutants deficient in FnBPA and/or FnBPB had reduced adherence to both ligands. Furthermore, overexpressing either FnBPA or FnBPB from a plasmid promoted bacterial adherence, indicating that both proteins are capable of binding to loricrin and K10 independently. S. aureus strains of clonal complex (CC) 1 are frequently isolated from AD patients and the factors contributing to CC1 persistence in AD skin are unknown. Here, it was shown that a panel of CC1 strains from AD (ADCC1) adhered more strongly to CDSN than commensals isolated from the nasal cavity of healthy children. CC30 strains are prevalent commensals of the nose of the healthy population. Three S. aureus ADCC1 strains, and two CC30 commensal strains were labelled with antibiotic resistance genes and competitive growth assays were carried out to determine whether ADCC1 strains have a competitive advantage over CC30 strains. Two of the three ADCC1 strains outcompeted growth of both CC30 isolates. Likely, the ability of ADCC1 strains to adhere strongly to CDSN in AD skin gives them a competitive advantage where they can then proliferate and outcompete other S. aureus isolates, to dominate the AD skin environment. Advisors/Committee Members: Geoghegan, Joan.

Subjects/Keywords: Staphylococcus aureus; Atopic Dermatitis; Microbiology; Skin disease

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

TOWELL, A. (2019). Investigating factors that contribute to the ability of Staphylococcus aureus to colonise atopic dermatitis skin. (Thesis). Trinity College Dublin. Retrieved from http://hdl.handle.net/2262/89186

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

TOWELL, AISLING. “Investigating factors that contribute to the ability of Staphylococcus aureus to colonise atopic dermatitis skin.” 2019. Thesis, Trinity College Dublin. Accessed January 18, 2021. http://hdl.handle.net/2262/89186.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

TOWELL, AISLING. “Investigating factors that contribute to the ability of Staphylococcus aureus to colonise atopic dermatitis skin.” 2019. Web. 18 Jan 2021.

Vancouver:

TOWELL A. Investigating factors that contribute to the ability of Staphylococcus aureus to colonise atopic dermatitis skin. [Internet] [Thesis]. Trinity College Dublin; 2019. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2262/89186.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

TOWELL A. Investigating factors that contribute to the ability of Staphylococcus aureus to colonise atopic dermatitis skin. [Thesis]. Trinity College Dublin; 2019. Available from: http://hdl.handle.net/2262/89186

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Missouri – Columbia

15. Fowler, Brooke L. Evaluation of autoimmune disease as a risk factor for lymphoma.

Degree: 2013, University of Missouri – Columbia

URL: https://doi.org/10.32469/10355/40185

► The immune system has an intricate relationship with cancer. It is responsible for the prevention, management, and resolution of cancer. In people and dogs autoimmune… (more)

Subjects/Keywords: Dogs – Immunology; Lymphomas in animals; Atopic dermatitis

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Fowler, B. L. (2013). Evaluation of autoimmune disease as a risk factor for lymphoma. (Thesis). University of Missouri – Columbia. Retrieved from https://doi.org/10.32469/10355/40185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Fowler, Brooke L. “Evaluation of autoimmune disease as a risk factor for lymphoma.” 2013. Thesis, University of Missouri – Columbia. Accessed January 18, 2021. https://doi.org/10.32469/10355/40185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Fowler, Brooke L. “Evaluation of autoimmune disease as a risk factor for lymphoma.” 2013. Web. 18 Jan 2021.

Vancouver:

Fowler BL. Evaluation of autoimmune disease as a risk factor for lymphoma. [Internet] [Thesis]. University of Missouri – Columbia; 2013. [cited 2021 Jan 18]. Available from: https://doi.org/10.32469/10355/40185.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Fowler BL. Evaluation of autoimmune disease as a risk factor for lymphoma. [Thesis]. University of Missouri – Columbia; 2013. Available from: https://doi.org/10.32469/10355/40185

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

16. Mazrier, Hamutal. Breed risk, immunophenotypes and genomic studies of canine atopic dermatitis .

Degree: 2013, University of Sydney

URL: http://hdl.handle.net/2123/12441

► BREED RISK, IMMUNOPHENOTYPES AND GENOMIC STUDIES OF CANINE ATOPIC DERMATITIS Canine atopic dermatitis (AD) is a complex genetically-linked immunological hypersensitivity which has similar clinical signs… (more)

▼ BREED RISK, IMMUNOPHENOTYPES AND GENOMIC STUDIES OF CANINE ATOPIC DERMATITIS Canine atopic dermatitis (AD) is a complex genetically-linked immunological hypersensitivity which has similar clinical signs and pathological features to human AD, and involves immune dysregulation and skin barrier impairment. This thesis examines genetic factors underpinning canine AD and focuses on breed prevalence and evaluation of changes in the blood. Sixteen breeds with increased relative risk (≥1.5) were identified and gender predisposition in two dog breeds was revealed. One clade of dog breeds is highly represented amongst AD patients worldwide, and with increased RR in Australia. A 19 cytokine/chemokine multiplex bio-assay measured significantly elevated CXCL8, IL-7 and IL-15 concentrations, and reduced Stem-cell factor (SCF) in plasma of canine AD patients (n=27) compared to controls (n=11). Microarray gene expression data from leukocytes of atopic dogs (n=6) and controls (n=6) revealed 603 differentially expressed (DE) genes. Amongst these, candidate immune-related genes were highlighted, including the most under-represented gene, IL-7 receptor alpha subunit (IL7R). Quantitative real time PCR confirmed reduced gene expression for genes of the IL-7/IL7R pathway. A significant enrichment cluster consisting of immune-related pathways was identified, including T-cell receptor and B-cell receptor pathways. Expression analysis of miRNA from leukocytes of AD dogs identified15 with differential patterns of expression. The miRNA cfa-miR-31 had low levels in atopic dogs, suggesting a potential immune impairment dysregulation. Integrating the data gathered in the array studies reported in this thesis together with the genetic structure of dog breeds provides a powerful model to enable better characterisation of Australian dog breed susceptibility to canine AD and breed-related phenotypes. The IL-7/IL7R pathway may play a key role in the immune response in canine AD, may provide biomarkers to assist with diagnoses, and is a potential target for therapeutic agents.

Subjects/Keywords: Canine; Atopic dermatitis; Breed-related phenotypes; Dog

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Mazrier, H. (2013). Breed risk, immunophenotypes and genomic studies of canine atopic dermatitis . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/12441

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Mazrier, Hamutal. “Breed risk, immunophenotypes and genomic studies of canine atopic dermatitis .” 2013. Thesis, University of Sydney. Accessed January 18, 2021. http://hdl.handle.net/2123/12441.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Mazrier, Hamutal. “Breed risk, immunophenotypes and genomic studies of canine atopic dermatitis .” 2013. Web. 18 Jan 2021.

Vancouver:

Mazrier H. Breed risk, immunophenotypes and genomic studies of canine atopic dermatitis . [Internet] [Thesis]. University of Sydney; 2013. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2123/12441.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Mazrier H. Breed risk, immunophenotypes and genomic studies of canine atopic dermatitis . [Thesis]. University of Sydney; 2013. Available from: http://hdl.handle.net/2123/12441

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

University of Sydney

17. Smith, Saxon Donald. Paediatric atopic dermatitis and treatment adherence: Exploring factors contributing to topical corticosteroid phobia as a contributor to poor treatment adherence .

Degree: 2017, University of Sydney

URL: http://hdl.handle.net/2123/18056

► Atopic dermatitis (AD), also known as eczema or atopic eczema, is the most common chronic inflammatory dermatosis (skin condition) affecting paediatric patients in the western… (more)

▼ Atopic dermatitis (AD), also known as eczema or atopic eczema, is the most common chronic inflammatory dermatosis (skin condition) affecting paediatric patients in the western world. There continues to be a rapid rise in incidence of this condition worldwide with a doubling of prevalence in children under age five years in the past 30 years. It also remains one of the most treatable with correct management. Topical corticosteroids (TCS), which have a topical anti-inflammatory action, remain central to this management. However, parent and patient poor adherence to prescribed treatment plans often leads to less effective control of their AD. A review of the literature demonstrated that one of the commonly cited contributing factors to treatment non-adherence in paediatric AD is a fear or anxiety regarding the use of TCS, a condition termed ‘TCS phobia’ (Chapter 2). Although moderate to severe atopic dermatitis is disabling and highly disruptive for patients and their families, TCS phobia is a significant barrier to effective treatment. This thesis presents a body of work that aims to identify the sources of information or misinformation about the safety and efficacy of TCS, as well as assessing the impact of this information on parents’ and patients’ perception on the long term use of TCS to manage their AD. Previous research has identified that parents of children with AD highlight the role of family and friends, the Internet, pharmacists and general practitioners as key sources of information that contribute to fear and anxiety towards using TCS to manage AD. This can create conflicting information leading to confusion and ultimately poor or non-adherence to prescribed treatment plans. This is especially the case when the conflicting information comes from different members of the multidisciplinary treatment team. A multidisciplinary treatment team incorporates health care professionals from different disciplines who provide a specific service and associated health information to the patients, and in the setting of AD in Australia includes general practitioners, dermatologists, and pharmacists. Therefore, it is important to investigate the knowledge and attitudes of these health professionals about the safety and efficacy of TCS that forms the advice provided to parents and patients in paediatric AD. This is because treatment adherence is directly related to risk/benefit of treating a condition as well as the perception of disease severity. If the perceived risks associated with treatment, such as TCS in paediatric AD, out way the perceived benefits or perceived disease severity, then there is significant risk of treatment non-adherence. A consensus statement and systematic review of the adverse effects arising from the use of TCS in children with atopic dermatitis was performed (Chapter 3). The aim of the consensus meeting was to identify the potential and perceived adverse effects and systematically review the literature for each. Dermatologists play a key role as clinical educators around the use, safety and…

Subjects/Keywords: Paediatric; Atopic dermatitis; Eczema; Topical corticosteroid; Phobia

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Smith, S. D. (2017). Paediatric atopic dermatitis and treatment adherence: Exploring factors contributing to topical corticosteroid phobia as a contributor to poor treatment adherence . (Thesis). University of Sydney. Retrieved from http://hdl.handle.net/2123/18056

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Smith, Saxon Donald. “Paediatric atopic dermatitis and treatment adherence: Exploring factors contributing to topical corticosteroid phobia as a contributor to poor treatment adherence .” 2017. Thesis, University of Sydney. Accessed January 18, 2021. http://hdl.handle.net/2123/18056.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Smith, Saxon Donald. “Paediatric atopic dermatitis and treatment adherence: Exploring factors contributing to topical corticosteroid phobia as a contributor to poor treatment adherence .” 2017. Web. 18 Jan 2021.

Vancouver:

Smith SD. Paediatric atopic dermatitis and treatment adherence: Exploring factors contributing to topical corticosteroid phobia as a contributor to poor treatment adherence . [Internet] [Thesis]. University of Sydney; 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/2123/18056.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Smith SD. Paediatric atopic dermatitis and treatment adherence: Exploring factors contributing to topical corticosteroid phobia as a contributor to poor treatment adherence . [Thesis]. University of Sydney; 2017. Available from: http://hdl.handle.net/2123/18056

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

18. Wolkerstorfer, Albert. Evaluation of severity and therapy in children with atopic dermatitis.

Degree: 1999, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/20009

► textabstractAtopic dennatitis (AD) is a conUllon chronically relapsing skin disorder affecting 9-20% of those born after 1970 [Schultz Larsen 1993]. TI,e aetiology is still not… (more)

▼ textabstractAtopic dennatitis (AD) is a conUllon chronically relapsing skin disorder affecting 9-20% of those born after 1970 [Schultz Larsen 1993]. TI,e aetiology is still not entirely elucidated and research is complicated by the multifactorial nature of the disease. Both genetical and environmental factors are involved in the pathogenesis of AD. The prevalence of atopic dennatitis seems to have increased along with astluna and allergic rhinitis during the past three decades [Williams 1992, Schultz Larsen 1996]. Several studies from different countries reported a two- to three-fold increase of the prevalence of AD over the past three decades. However, the reasons for this evolution of atopic diseases still remain to be elucidated. Furthennore, large, unexplained variations in prevalence have been reported between countries and within countries [ISAAC 1998], suggesting a critical role for environmental thctors in disease expression. Although some risk factors such as gender, parental smoking, and early exposure to allergens Olouse dust mite, pets, cow's milk and solid food) have becn identified, the role of other risk factors like socio-economic status, outdoor and indoor pollution and infections in early life are still a matter of discussion. Studies on the genetical and immunological background have provided new insights into the mechanisms involved in atopic diseases. However, therapeutical practice has not yet changed. Recently guidelines based on consensus have been established for the management of AD [Me Henry 1995]. Emphasis is put on educating and infonning the patients. Although these and other guidelines provide a good franlework for managing AD, the unpredictable course of the disease with exacerbations and remissions may fiustrate both patients and physicians [przybilla 1994]. Patients with AD account for about 30% of demlatological consultations in general practice, and dennatological consultations account for about 20% of all consultations in general practice [Rook 1986]. However, little attention has been paid to AD in tenns of research. A Medline literature search (title, abstract, and subject heading) from 1996 to May 1999 showed 8,986 publications related to astlUlla, but only 942 related to AD. This is surprising when the impact of the two diseases is compared. In tenns of prevalence, AD is more conunon than asthma in Y01Ulg children [Peat 1994, Burr 1989]; in tenns of economic resources, the direct fimUlcial cost in the care of a child with moderate to severe AD is substantially higher than for the average child with asthma [Su 1997]; and in tenns of family impact - taking into account fmaneial burden, familial/social impact, personal strain and mastery - even in mild AD, the impact on fanlilies was found to be equivalent to that for children with insulin dependent diabetes mellitus [Su 1997]. Consequently AD should not be percei

Subjects/Keywords: atopic dermatitis; children; dermatitis; dermatology

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Wolkerstorfer, A. (1999). Evaluation of severity and therapy in children with atopic dermatitis. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/20009

Chicago Manual of Style (16^th Edition):

Wolkerstorfer, Albert. “Evaluation of severity and therapy in children with atopic dermatitis.” 1999. Doctoral Dissertation, Erasmus University Medical Center. Accessed January 18, 2021. http://hdl.handle.net/1765/20009.

MLA Handbook (7^th Edition):

Wolkerstorfer, Albert. “Evaluation of severity and therapy in children with atopic dermatitis.” 1999. Web. 18 Jan 2021.

Vancouver:

Wolkerstorfer A. Evaluation of severity and therapy in children with atopic dermatitis. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 1999. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1765/20009.

Council of Science Editors:

Wolkerstorfer A. Evaluation of severity and therapy in children with atopic dermatitis. [Doctoral Dissertation]. Erasmus University Medical Center; 1999. Available from: http://hdl.handle.net/1765/20009

Universitat de Barcelona

19. Moner del Moral, Verónica. Sistemas miméticos de los cuerpos laminares epidérmicos para el tratamiento de la piel.

Degree: 2018, Universitat de Barcelona

URL: http://hdl.handle.net/10803/664682

► The stratum corneum (SC) is the uppermost epidermal layer. It is composed of corneocytes embedded in a lipid intercellular matrix organized in a lamellar structure.… (more)

▼ The stratum corneum (SC) is the uppermost epidermal layer. It is composed of corneocytes embedded in a lipid intercellular matrix organized in a lamellar structure. This lipid matrix consists of ceramides, cholesterol and free fatty acids with a minor amount of cholesteryl sulfate. The specific structure of the SC acts as a barrier preventing water loss and bacterial infection. Epidermal lamellar bodies are secretory organelles responsible of the correct formation of the SC lipid structure. Many skin diseases like atopic dermatitis has dysfunctional lamellar bodies, producing alteration in SC lipid composition. Consequently, the skin displays impaired barrier function. The aim of this thesis was to design a lipid system that mimics the morphology, structure and composition of epidermal lamellar bodies with the purpose to mimic also their function. Different lipid systems (LBms) were prepared including SC lipids in addition to lipids with antimicrobial effect. The electron microscopy images show that these systems are formed by vesicles encapsulating discoidal structures like the endogenous organelles. In addition, we performed in vitro studies to evaluate the effect of the LBms on delipidated SC. We found that the lipid system penetrates through the spaces of the SC and re-establishes the lipid lamellar structure of the SC. Moreover, the LBms that approximates in major proportion the SC lipid composition was the most effective restoring the SC lipid structure. In other study, we evaluated in vivo the hydration-dehydration kinetics of human skin after treatment with the LBms. We found that the skin increases its ability to retain water. Thus, this lipid system seems to reinforce the skin barrier function. Furthermore, we evaluated the effect of the treatment with the LBms on oxazolone-induced atopic dermatitis mouse model. We found an improvement of the skin lesions after treatment by visual inspection. In addition, the treatment with the LBms reduced transepidermal water loss indicating a recovery of the barrier. It also reduced skin inflammation. These results point to a high potential of the LBms to improve skin conditions. Therefore, this lipid system could be of interest for the development of future treatment for atopic dermatitis. Advisors/Committee Members: Universitat de Barcelona. Facultat de Farmàcia i Ciències de l'Alimentació, [email protected] (authoremail), false (authoremailshow), López Serrano, Olga (director).

Subjects/Keywords: Epidermis; Dermatitis atòpica; Dermatitis atópica; Atopic dermatitis; Ciències de la Salut; 615

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Moner del Moral, V. (2018). Sistemas miméticos de los cuerpos laminares epidérmicos para el tratamiento de la piel. (Thesis). Universitat de Barcelona. Retrieved from http://hdl.handle.net/10803/664682

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Moner del Moral, Verónica. “Sistemas miméticos de los cuerpos laminares epidérmicos para el tratamiento de la piel.” 2018. Thesis, Universitat de Barcelona. Accessed January 18, 2021. http://hdl.handle.net/10803/664682.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Moner del Moral, Verónica. “Sistemas miméticos de los cuerpos laminares epidérmicos para el tratamiento de la piel.” 2018. Web. 18 Jan 2021.

Vancouver:

Moner del Moral V. Sistemas miméticos de los cuerpos laminares epidérmicos para el tratamiento de la piel. [Internet] [Thesis]. Universitat de Barcelona; 2018. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10803/664682.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Moner del Moral V. Sistemas miméticos de los cuerpos laminares epidérmicos para el tratamiento de la piel. [Thesis]. Universitat de Barcelona; 2018. Available from: http://hdl.handle.net/10803/664682

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

RMIT University

20. Gu, X. Evaluation of efficacy and safety of topical application of Chinese herbal medicine for atopic eczema: a systematic review and protocol for pilot randomised double-blind placebo-controlled trial.

Degree: 2011, RMIT University

URL: http://researchbank.rmit.edu.au/view/rmit:160115

► Background: Atopic eczema (AE) or infantile eczema is an inflammatory skin disease, which affects 10-20% of children in industrialised countries. Australia was the 12th highest… (more)

▼ Background: Atopic eczema (AE) or infantile eczema is an inflammatory skin disease, which affects 10-20% of children in industrialised countries. Australia was the 12th highest rank of AE incidence in 55 participating countries. AE is characterised by poorly demarcated redness of the skin and associated surface changes such as scaling, swelling, accentuation of the hair follicles and skin thickening as a result of chronic scratching. There are three common quoted diagnostic criteria for determination of AE for the purpose of research and clinical studies. In addition, reliable scoring instrument such as Scoring Atopic Dermatitis (SCORAD) is fundamental for clinicians to verify the severity, the course and outcomes of treatment for AE. Certain quality of life (QoL) questionnaires have also been developed and validated for assessment of the personal impact and outcomes of the treatment for AE. The conventional (Western) medicine treatment for AE is not satisfactory. Complementary and alternative medicine including Chinese herbal medicine (CHM) has been increasingly used for AE. There is some promising published evidence on oral administration of CHM for AE. However, the benefit of topical application of CHM for AE is not clear. Aims: a) To review fundamental knowledge of AE in perspectives of both conventional medicine and Chinese medicine (CM); b) To evaluate the effectiveness and safety of topical application of CHM for AE by systematically reviewing currently available randomised controlled trials (RCTs); and c) To develop a protocol for pilot randomised double-blind placebo-controlled clinical trial for evaluation of the efficacy and safety of topical application of CHM for AE. Methods: We searched any RCTs with topical application of CHM in electronic databases and journals. Trial-design quality was evaluated and intervention outcome data were extracted and analysed. Meta-analysis was conducted. Development of a protocol for pilot RCT of topical application of CHM for AE followed the Australian Governmentâ€™s guidelines in compliance with high ethical standard. Results: Three studies involving a total of 452 participants were selected for analysis after screening 164 potential studies. All three included studies reported significant differences between the treatment group and controlled group and claimed that effects of treatment interventions were superior to control. However, due to the low quality of study design which resulted in low level of evidence strength, these claims require more vigorous scientific proof employing well designed RCTs. As a result, a protocol for pilot randomised double-blind placebo-controlled clinical trial for evaluation of the efficacy and safety of topical application of CHM for AE was developed. Conclusion: The systematic review in this thesis is the first one conducted in topical application of CHM for AE. Detailed analysis of the three included studies led to the conclusion of low level of evidence strength. Thus, they did not provide convincing evidential support for…

Subjects/Keywords: Fields of Research; Chinese medicine; Chinese herbal medicine; atopic eczema; atopic dermatitis; systematic review

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Gu, X. (2011). Evaluation of efficacy and safety of topical application of Chinese herbal medicine for atopic eczema: a systematic review and protocol for pilot randomised double-blind placebo-controlled trial. (Thesis). RMIT University. Retrieved from http://researchbank.rmit.edu.au/view/rmit:160115

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Gu, X. “Evaluation of efficacy and safety of topical application of Chinese herbal medicine for atopic eczema: a systematic review and protocol for pilot randomised double-blind placebo-controlled trial.” 2011. Thesis, RMIT University. Accessed January 18, 2021. http://researchbank.rmit.edu.au/view/rmit:160115.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Gu, X. “Evaluation of efficacy and safety of topical application of Chinese herbal medicine for atopic eczema: a systematic review and protocol for pilot randomised double-blind placebo-controlled trial.” 2011. Web. 18 Jan 2021.

Vancouver:

Gu X. Evaluation of efficacy and safety of topical application of Chinese herbal medicine for atopic eczema: a systematic review and protocol for pilot randomised double-blind placebo-controlled trial. [Internet] [Thesis]. RMIT University; 2011. [cited 2021 Jan 18]. Available from: http://researchbank.rmit.edu.au/view/rmit:160115.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Gu X. Evaluation of efficacy and safety of topical application of Chinese herbal medicine for atopic eczema: a systematic review and protocol for pilot randomised double-blind placebo-controlled trial. [Thesis]. RMIT University; 2011. Available from: http://researchbank.rmit.edu.au/view/rmit:160115

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

21. Devillers, Arjan. Diagnostic Work-up and Treatment of Severe and/or Refractory Atopic Dermatitis.

Degree: Department of Dermatology, 2009, Erasmus University Medical Center

URL: http://hdl.handle.net/1765/14802

► textabstractAtopic dermatitis (AD) or atopic eczema , is a chronic inflammatory skin disease characterized by dry skin, itching and recurrent red and scaly skin lesions.… (more)

Subjects/Keywords: atopic dermatitis; atopic eczema; skin disease

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Devillers, A. (2009). Diagnostic Work-up and Treatment of Severe and/or Refractory Atopic Dermatitis. (Doctoral Dissertation). Erasmus University Medical Center. Retrieved from http://hdl.handle.net/1765/14802

Chicago Manual of Style (16^th Edition):

Devillers, Arjan. “Diagnostic Work-up and Treatment of Severe and/or Refractory Atopic Dermatitis.” 2009. Doctoral Dissertation, Erasmus University Medical Center. Accessed January 18, 2021. http://hdl.handle.net/1765/14802.

MLA Handbook (7^th Edition):

Devillers, Arjan. “Diagnostic Work-up and Treatment of Severe and/or Refractory Atopic Dermatitis.” 2009. Web. 18 Jan 2021.

Vancouver:

Devillers A. Diagnostic Work-up and Treatment of Severe and/or Refractory Atopic Dermatitis. [Internet] [Doctoral dissertation]. Erasmus University Medical Center; 2009. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/1765/14802.

Council of Science Editors:

Devillers A. Diagnostic Work-up and Treatment of Severe and/or Refractory Atopic Dermatitis. [Doctoral Dissertation]. Erasmus University Medical Center; 2009. Available from: http://hdl.handle.net/1765/14802

University of Oxford

22. Hlela, Carol. Human T-lymphotropic virus type 1(HTLV-1) associated infective dermatitis.

Degree: PhD, 2011, University of Oxford

URL: http://ora.ox.ac.uk/objects/uuid:48d8069a-9bd3-4cdc-9474-8246564c03e8 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543541

► Human T lymphotropic virus type -1 (HTLV-1) infections are important causes of mortality and morbidity in endemic areas worldwide. There is neither a vaccine specific… (more)

▼ Human T lymphotropic virus type -1 (HTLV-1) infections are important causes of mortality and morbidity in endemic areas worldwide. There is neither a vaccine specific for the virus nor satisfactory treatment for the associated malignancy or inflammatory syndromes. HTLV-1 associated infective dermatitis (IDH) is a chronic dermatitis that has been observed in a variable proportion of HTLV-1 infected children. IDH may serve as an early clinical marker for HTLV-1 and an indicator of increased risk for developing other HTLV-1 associated conditions such as adult T cell leukaemia/lymphoma (ATLL) and HTLV-1-associated myelopathy or transient spastic paraparesis (HAM/TSP). However the mechanisms underlying IDH and the relationships with HAM/TSP and ATLL are poorly understood. We undertook skin biopsies from 14 cases with IDH, and controls which included five asymptomatic carriers (ACs) and 18 healthy uninfected individuals from South Africa. We conducted clinical assessments, proviral load, allergen-specific IgE, peripheral blood and cutaneous T cell and virological analyses. We obtained relevant clinical history and examined all cases and controls based on a pre-formed questionnaire. Despite the partial clinical similarities with atopic dermatitis, the individuals with IDH did not have an increased incidence of atopic disease including asthma or rhinitis. Furthermore house dust mite-specific IgE levels were not elevated in the cases compared to the controls, suggesting that atopy is not a predisposing factor for the development of IDH in HTLV-1 infected individuals. Circulating proviral load was significantly higher in those with IDH compared to asymptomatic carriers and skin biopsy revealed acanthosis, and lymphocytic epidermotropism associated with a superficial perivascular and periadnexal lymphocytic infiltration of CD8+, and CD4+ T cells. Furthermore IDH associated with an infiltrate of epidermal and dermal FoxP3+ T cells and lesional down-regulation of filaggrin expression compared to non-lesional skin. We did not observe an elevation of pro-inflammatory cytokines in the sera of individuals with IDH compared to the controls. We investigated integration patterns in the skin and blood of 10 cases with IDH, and two asymptomatic carrier (AC) individuals from South Africa. We first showed that the virus is present in the skin at high levels (total mean levels of 47.09 proviral copies per 1000 cells) as comparable to that which has been observed in blood (total mean levels 137 proviral copies per 1000 cells). Using a high throughput Illumina sequencing system in collaboration with Professor Bangham, we mapped and quantified the relationship between oligoclonal proliferation of HTLV-1 infected T cells in the skin and blood of IDH patients. It was found that in IDH, a selective outgrowth of certain clones is favoured, supporting the possibility of skin-specific factors exerting positive selection on proliferation. In IDH, there was not a preferential integration of the provirus in transcriptionally active regions of the gene…

Subjects/Keywords: 616.5; Medical Sciences; Infectious diseases; Clinical laboratory sciences; infectious dermatitis; atopic dermatitis; FoxP3 T cells

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hlela, C. (2011). Human T-lymphotropic virus type 1(HTLV-1) associated infective dermatitis. (Doctoral Dissertation). University of Oxford. Retrieved from http://ora.ox.ac.uk/objects/uuid:48d8069a-9bd3-4cdc-9474-8246564c03e8 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543541

Chicago Manual of Style (16^th Edition):

Hlela, Carol. “Human T-lymphotropic virus type 1(HTLV-1) associated infective dermatitis.” 2011. Doctoral Dissertation, University of Oxford. Accessed January 18, 2021. http://ora.ox.ac.uk/objects/uuid:48d8069a-9bd3-4cdc-9474-8246564c03e8 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543541.

MLA Handbook (7^th Edition):

Hlela, Carol. “Human T-lymphotropic virus type 1(HTLV-1) associated infective dermatitis.” 2011. Web. 18 Jan 2021.

Vancouver:

Hlela C. Human T-lymphotropic virus type 1(HTLV-1) associated infective dermatitis. [Internet] [Doctoral dissertation]. University of Oxford; 2011. [cited 2021 Jan 18]. Available from: http://ora.ox.ac.uk/objects/uuid:48d8069a-9bd3-4cdc-9474-8246564c03e8 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543541.

Council of Science Editors:

Hlela C. Human T-lymphotropic virus type 1(HTLV-1) associated infective dermatitis. [Doctoral Dissertation]. University of Oxford; 2011. Available from: http://ora.ox.ac.uk/objects/uuid:48d8069a-9bd3-4cdc-9474-8246564c03e8 ; http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543541

23. Leyva Castillo, Juan Manuel. Etude du rôle de la cytokine thymic stromal lymphopoietin (TSLP) produite par les keratinocytes dans la marche atopique : Study of the role of the thymic stromal lymphopoietin (TSLP) in the atopic march.

Degree: Docteur es, Aspects moléculaires et cellulaires de la biologie, 2012, Université de Strasbourg

URL: http://www.theses.fr/2012STRAJ059

►

La marche atopique désigne la progression séquentielle des maladies atopiques, en particulier l’apparition d’asthme chez les enfants précédée par celle d’une dermatite atopique (DA) sévère… (more)

▼

La marche atopique désigne la progression séquentielle des maladies atopiques, en particulier l’apparition d’asthme chez les enfants précédée par celle d’une dermatite atopique (DA) sévère chez les nourrissons. De plus, l’asthme est influencé par le degré de sévérité de la DA, qui pourrait ainsi être considérée comme la porte d’entrée pour le développement ultérieur d’une inflammation allergique des voies aériennes.Mon travail de thèse a consisté à déterminer l’implication de la cytokine TSLP produite par les kératinocytes pendant la marche atopique et implication de la cytokine TSLP pendant le développement de la DA. Pour atteindre ces objectifs, j’ai utilisé des modèles murins de maladies atopiques, en combinaison avec plusieurs lignées de souris génétiquement modifiées.Dans la première partie de mon travail de thèse, nous avons montré que la production de la cytokine TSLP dans les kératinocytes est un facteur nécessaire, non seulement pour l’inflammation cutanée, mais aussi pour générer une réponse immunitaire systémique à l’allergène.Dans la deuxième partie de mon travail de thèse, nous avons montré que la cytokine TSLP induise un recrutement de basophiles d’une façon innée, suite d’une augmentation de ce recrutement induit par l'immunité adaptative. De plus, nous avons montré que la réponse de type “Th2” induit par la cytokine TSLP ce le résultat de une coopération coordonnée de cellules dendritiques, de cellules T CD4+ et de basophiles. Des études cliniques sont nécessaires pour déterminer si l’inhibition de l’expression de la cytokine TSLP et/ou son activité pendant une DA peut réduire l’inflammation cutanée et prévenir la sensibilisation aux allergènes.

Atopic march refers to the natural history of allergic diseases, which is characterized by a typical sequence of sensitization and manifestation of symptoms in different tissues. Commonly, the clinical manifestation of atopic dermatitis (AD) appears in the early life and precedes the development of airway allergic diseases. AD has been proposed as an entry point for subsequent atopic diseases.The objective of my thesis was to better understand the role of TSLP in the atopic march and the cascade events initiated by TSLP in vivo in the development of AD. To reach my thesis objectives we used mouse models of atopic diseases in combination with various deficient-mouse lines.In the first part of this work, using a atopic march mouse model developed during my PhD work, we demonstrated that keratinocytic TSLP is essentially required not only for the development of allergic skin inflammation, but also for the generation of the allergen-specific immune response. In the second part of this work, using a cytokine TSLP-induced AD mouse model (topical MC903 treatment), we demonstrated that skin TSLP induces an early innate recruitment of basophils in the skin, followed by a late recruitment involving adaptive immunity. In addition, we demonstrate that TSLP-induced Th2 response requires an orchestrated cooperation of dendritic cells, CD4+ T cells and basophils.This work…

Advisors/Committee Members: Metzger, Daniel (thesis director), Chambon, Pierre (thesis director).

Subjects/Keywords: Cytokine TSLP; Marche atopique; Dermatite atopique; Asthme; TSLP; Atopic march; Atopic dermatitis; Asthma; Atopic diseases; 571.96; 616.5

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Leyva Castillo, J. M. (2012). Etude du rôle de la cytokine thymic stromal lymphopoietin (TSLP) produite par les keratinocytes dans la marche atopique : Study of the role of the thymic stromal lymphopoietin (TSLP) in the atopic march. (Doctoral Dissertation). Université de Strasbourg. Retrieved from http://www.theses.fr/2012STRAJ059

Chicago Manual of Style (16^th Edition):

Leyva Castillo, Juan Manuel. “Etude du rôle de la cytokine thymic stromal lymphopoietin (TSLP) produite par les keratinocytes dans la marche atopique : Study of the role of the thymic stromal lymphopoietin (TSLP) in the atopic march.” 2012. Doctoral Dissertation, Université de Strasbourg. Accessed January 18, 2021. http://www.theses.fr/2012STRAJ059.

MLA Handbook (7^th Edition):

Leyva Castillo, Juan Manuel. “Etude du rôle de la cytokine thymic stromal lymphopoietin (TSLP) produite par les keratinocytes dans la marche atopique : Study of the role of the thymic stromal lymphopoietin (TSLP) in the atopic march.” 2012. Web. 18 Jan 2021.

Vancouver:

Leyva Castillo JM. Etude du rôle de la cytokine thymic stromal lymphopoietin (TSLP) produite par les keratinocytes dans la marche atopique : Study of the role of the thymic stromal lymphopoietin (TSLP) in the atopic march. [Internet] [Doctoral dissertation]. Université de Strasbourg; 2012. [cited 2021 Jan 18]. Available from: http://www.theses.fr/2012STRAJ059.

Council of Science Editors:

Leyva Castillo JM. Etude du rôle de la cytokine thymic stromal lymphopoietin (TSLP) produite par les keratinocytes dans la marche atopique : Study of the role of the thymic stromal lymphopoietin (TSLP) in the atopic march. [Doctoral Dissertation]. Université de Strasbourg; 2012. Available from: http://www.theses.fr/2012STRAJ059

Universiteit Utrecht

24. Hillen, M.R. The role of CD8+ T-cells in the pathogenesis of Atopic Dermatitis.

Degree: 2010, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/187130

► Atopic Dermatitis (AD) is a chronic T-cell mediated inflammatory disease. Unlike most allergic diseases, Th2 polarization is only associated to acute AD lesions, while a… (more)

Subjects/Keywords: Atopic Dermatitis; CD8+ T-cells; Pathogenesis; CD8+ Tregs

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Hillen, M. R. (2010). The role of CD8+ T-cells in the pathogenesis of Atopic Dermatitis. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/187130

Chicago Manual of Style (16^th Edition):

Hillen, M R. “The role of CD8+ T-cells in the pathogenesis of Atopic Dermatitis.” 2010. Masters Thesis, Universiteit Utrecht. Accessed January 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/187130.

MLA Handbook (7^th Edition):

Hillen, M R. “The role of CD8+ T-cells in the pathogenesis of Atopic Dermatitis.” 2010. Web. 18 Jan 2021.

Vancouver:

Hillen MR. The role of CD8+ T-cells in the pathogenesis of Atopic Dermatitis. [Internet] [Masters thesis]. Universiteit Utrecht; 2010. [cited 2021 Jan 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/187130.

Council of Science Editors:

Hillen MR. The role of CD8+ T-cells in the pathogenesis of Atopic Dermatitis. [Masters Thesis]. Universiteit Utrecht; 2010. Available from: http://dspace.library.uu.nl:8080/handle/1874/187130

Universiteit Utrecht

25. Tol, S.E. van. Innate lymphoid cells in atopic dermatitis.

Degree: 2014, Universiteit Utrecht

URL: http://dspace.library.uu.nl:8080/handle/1874/296416

► Th2 immunity was evolved for the immune response against parasites. Basophils, eosinophils, mast cells and Th2 cells are characteristic cell types in Th2 immunity. Furthermore… (more)

Subjects/Keywords: Atopic dermatitis; innate lymphoid cells; ILC2s; Th2 immune response

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tol, S. E. v. (2014). Innate lymphoid cells in atopic dermatitis. (Masters Thesis). Universiteit Utrecht. Retrieved from http://dspace.library.uu.nl:8080/handle/1874/296416

Chicago Manual of Style (16^th Edition):

Tol, S E van. “Innate lymphoid cells in atopic dermatitis.” 2014. Masters Thesis, Universiteit Utrecht. Accessed January 18, 2021. http://dspace.library.uu.nl:8080/handle/1874/296416.

MLA Handbook (7^th Edition):

Tol, S E van. “Innate lymphoid cells in atopic dermatitis.” 2014. Web. 18 Jan 2021.

Vancouver:

Tol SEv. Innate lymphoid cells in atopic dermatitis. [Internet] [Masters thesis]. Universiteit Utrecht; 2014. [cited 2021 Jan 18]. Available from: http://dspace.library.uu.nl:8080/handle/1874/296416.

Council of Science Editors:

Tol SEv. Innate lymphoid cells in atopic dermatitis. [Masters Thesis]. Universiteit Utrecht; 2014. Available from: http://dspace.library.uu.nl:8080/handle/1874/296416

26. 酒井, 貴史. Defective maintenance of pH of stratum corneum is correlated with preferential emergence and exacerbation of atopic-dermatitis-like dermatitis in flaky-tail mice.

Degree: 博士(医学), 2016, Oita University / 大分大学

URL: http://hdl.handle.net/10559/15616

►

Background: Neutralization of stratum corneum (SC) pH, which is induced by a variety of stimuli, such as scratching, use of soap and inflammation, can stimulate… (more)

Subjects/Keywords: Stratum corneum pH; Atopic dermatitis; Flaky-tail mice; Filaggrin

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

酒井, �. (2016). Defective maintenance of pH of stratum corneum is correlated with preferential emergence and exacerbation of atopic-dermatitis-like dermatitis in flaky-tail mice. (Thesis). Oita University / 大分大学. Retrieved from http://hdl.handle.net/10559/15616

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

酒井, 貴史. “Defective maintenance of pH of stratum corneum is correlated with preferential emergence and exacerbation of atopic-dermatitis-like dermatitis in flaky-tail mice.” 2016. Thesis, Oita University / 大分大学. Accessed January 18, 2021. http://hdl.handle.net/10559/15616.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

酒井, 貴史. “Defective maintenance of pH of stratum corneum is correlated with preferential emergence and exacerbation of atopic-dermatitis-like dermatitis in flaky-tail mice.” 2016. Web. 18 Jan 2021.

Vancouver:

酒井 �. Defective maintenance of pH of stratum corneum is correlated with preferential emergence and exacerbation of atopic-dermatitis-like dermatitis in flaky-tail mice. [Internet] [Thesis]. Oita University / 大分大学; 2016. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10559/15616.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

酒井 �. Defective maintenance of pH of stratum corneum is correlated with preferential emergence and exacerbation of atopic-dermatitis-like dermatitis in flaky-tail mice. [Thesis]. Oita University / 大分大学; 2016. Available from: http://hdl.handle.net/10559/15616

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

27. Victor do Espirito Santo Cunha. Avaliação da sensibilidade de cães com dermatite alérgica aos extratos alergênicos padronizados de ácaros da poeira domiciliar.

Degree: 2006, Universidade Federal Rural do Rio de Janeiro

URL: http://bdtd.ufrrj.br//tde_busca/arquivo.php?codArquivo=20

►

O presente estudo do tipo caso-controle teve como objetivo avaliar se extratos alergênicos de cinco espécies de ácaros da poeira domiciliar padronizados para humanos podem… (more)

▼

O presente estudo do tipo caso-controle teve como objetivo avaliar se extratos alergênicos de cinco espécies de ácaros da poeira domiciliar padronizados para humanos podem ser utilizados no diagnóstico da dermatite atópica canina. Extratos de Dermatophagoides pteronyssinus, D. farinae, Blomia tropicalis, Lepidoglyphus destructor e Tyrophagus putrescentiae foram avaliados através de testes intradérmicos em 45 cães, dos quais 20 controles e 25 com dermatite alérgica. Uma diferença significativa foi observada no padrão de respostas entre os dois grupos (p<0,05). Apenas um animal (5%) do grupo controle reagiu ao teste cutâneo, enquanto que no grupo dos alérgicos 14 cães (56%) apresentaram pelo menos uma reação positiva (odds ratio = 24,2). As maiores freqüências de reações positivas observadas no grupo dos alérgicos foram aos extratos de T. putrescentiae ou L. destructor, cada um induzindo reações em 10 (40%) cães. Os extratos de D. farinae, D. pteronyssinus e B. tropicalis foram responsáveis por reações positivas em 7 (28%), 3 (12%) e 3 (12%) cães, respectivamente. A sensibilidade e a especificidade dos testes intradérmicos foram de 56% e 95%, respectivamente e, o valor preditivo positivo e valor preditivo negativo de 93% e 63%, respectivamente. .

The objective of this case-control study was to evaluate whether allergenic extracts from five species of house dust mites standardized for humans may be taken into account in the diagnosis of the canine atopic dermatitis. Extracts of Dermatophagoides pteronyssinus, D. farinae, Blomia tropicalis, Lepidoglyphus destructor and Tyrophagus putrescentiae have been evaluated through intradermal testing on 45 dogs, from which 20 belonged to the control group and 25 suffered from allergic dermatitis. There was a significant difference on the response pattern between the two groups (p<0,05). Only one dog (5%) from the control group has reacted to the intradermal test, whereas from the allergic group, 14 dogs (56%) have presented at least one positive reaction (odds ratio = 24,2). Most of the positive reactions observed in the allergic group were to the extracts of T. putrescentiae or L. destructor, each one inducing reactions on ten dogs (40%). The D. farinae, D. pteronyssinus e B. tropicalis extracts were responsible for positive reactions on 7 (28%), 3 (12%) and 3 (12%) dogs, respectively. The intradermal testing sensitivity and specificity were 56% and 95%, respectively, and the positive predictive value and the negative predictive value were 93% and 63%, respectively.

Advisors/Committee Members: João Luiz Horacio Faccini.

Subjects/Keywords: alergia; teste intradérmico; dermatite atópica; atopic dermatitis; intradermal testing; PARASITOLOGIA; allergy

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Cunha, V. d. E. S. (2006). Avaliação da sensibilidade de cães com dermatite alérgica aos extratos alergênicos padronizados de ácaros da poeira domiciliar. (Thesis). Universidade Federal Rural do Rio de Janeiro. Retrieved from http://bdtd.ufrrj.br//tde_busca/arquivo.php?codArquivo=20

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Cunha, Victor do Espirito Santo. “Avaliação da sensibilidade de cães com dermatite alérgica aos extratos alergênicos padronizados de ácaros da poeira domiciliar.” 2006. Thesis, Universidade Federal Rural do Rio de Janeiro. Accessed January 18, 2021. http://bdtd.ufrrj.br//tde_busca/arquivo.php?codArquivo=20.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Cunha, Victor do Espirito Santo. “Avaliação da sensibilidade de cães com dermatite alérgica aos extratos alergênicos padronizados de ácaros da poeira domiciliar.” 2006. Web. 18 Jan 2021.

Vancouver:

Cunha VdES. Avaliação da sensibilidade de cães com dermatite alérgica aos extratos alergênicos padronizados de ácaros da poeira domiciliar. [Internet] [Thesis]. Universidade Federal Rural do Rio de Janeiro; 2006. [cited 2021 Jan 18]. Available from: http://bdtd.ufrrj.br//tde_busca/arquivo.php?codArquivo=20.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Cunha VdES. Avaliação da sensibilidade de cães com dermatite alérgica aos extratos alergênicos padronizados de ácaros da poeira domiciliar. [Thesis]. Universidade Federal Rural do Rio de Janeiro; 2006. Available from: http://bdtd.ufrrj.br//tde_busca/arquivo.php?codArquivo=20

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

28. Ito, Jun. Breastfeeding and risk of atopic dermatitis up to the age 42 months: a birth cohort study in Japan.

Degree: 博士(医学), 2017, Mie University / 三重大学

URL: http://hdl.handle.net/10076/00017128

►

Purpose: The purpose of this study was to investigate the association between breastfeeding and atopic dermatitis (AD) up to the age 42 months.Methods: Data from… (more)

Subjects/Keywords: Breastfeeding; Infant formula; Atopic dermatitis; Allergy; Cohort study

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Ito, J. (2017). Breastfeeding and risk of atopic dermatitis up to the age 42 months: a birth cohort study in Japan. (Thesis). Mie University / 三重大学. Retrieved from http://hdl.handle.net/10076/00017128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Ito, Jun. “Breastfeeding and risk of atopic dermatitis up to the age 42 months: a birth cohort study in Japan.” 2017. Thesis, Mie University / 三重大学. Accessed January 18, 2021. http://hdl.handle.net/10076/00017128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Ito, Jun. “Breastfeeding and risk of atopic dermatitis up to the age 42 months: a birth cohort study in Japan.” 2017. Web. 18 Jan 2021.

Vancouver:

Ito J. Breastfeeding and risk of atopic dermatitis up to the age 42 months: a birth cohort study in Japan. [Internet] [Thesis]. Mie University / 三重大学; 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10076/00017128.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Ito J. Breastfeeding and risk of atopic dermatitis up to the age 42 months: a birth cohort study in Japan. [Thesis]. Mie University / 三重大学; 2017. Available from: http://hdl.handle.net/10076/00017128

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

29. Tsotra, Kyriaki. Μελέτη για την πρόκληση παραγωγής καθελισιδίνης σε παιδιά με ατοπική δερματίτιδα μετά από χορήγηση βιταμίνης D.

Degree: 2017, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)

URL: http://hdl.handle.net/10442/hedi/41769

► Atopic dermatitis (AD) is a chronic skin disease of unknown etiology. It is usually detected during the early years of life, sometimes during infancy. Rarely,… (more)

▼ Atopic dermatitis (AD) is a chronic skin disease of unknown etiology. It is usually detected during the early years of life, sometimes during infancy. Rarely, it may develop for the first time in adulthood. It involves 15-30% of children, while in adults the frequency is reduced to 2-10% (1). Clinical features of the disease are itching, dry skin and thickening of the stratum corneum (lichenification). The pathogenesis of atopic dermatitis seems to be the result of genetic predisposition and immunological dysfunction of the epidermal barrier (2, 3). The skin is the first defense mechanism of the organism. Its permeability is determined by the interaction of keratinocytes with a group of proteins and certain enzymes and lipids. Any disturbance of these components, histological or functional, could deteriorate the normal function of the epidermal barrier and trigger the disease. For instance, injuries may predispose to susceptibility in invading microbial agents to the skin thus; triggering an immune response. This results in phagocytosis of these agents by neutrophils and macrophages and the production of mediators of inflammation. A common problem of patients suffering from AD are cutaneous infections, especially from Staphylococcus aureus and to a lesser extent by herpes simplex. During the last decade, a group of small cationic antimicrobial peptides (AMPs) has been described which seem to have a direct relationship with the pathogenesis of atopic dermatitis. These peptides are produced both by keratinocytes and blood cells, particularly neutrophils and monocytes. Leave along their direct bactericidal effect, AMPs also seem to mediate the immune response in the epidermis. Cathelicidin is the main representative of the family of AMPs. Human cathelicidin, usually referred as LL-37, or hCAP18, has bactericidal (disrupts the cell membrane of bacteria), antiviral and antifungal, properties (4). It has also been found to play a role in chemotaxis, angiogenesis and wound healing (5, 6). In normal skin, the concentration of cathelicidin is small but it significantly increases after disruption of the epidermal barrier, eg after injury or in some chronic inflammatory skin diseases such as psoriasis. In cases, however, with atopic dermatitis this effect is not triggered as the epidermis lose its potential in AMP production (7). This effect seems to, also, reflect the increased incidence of infections in this category of patients. Vitamin D levels are directly related to daily consumption and its production in the skin. Recent studies suggest that vitamin D seem to be an important regulator of cathelicidin production in the dermis (8, 9). Specifically, researchers have shown that dermal wounds and infections result in a significant increase of the CYP27B1 enzyme which converts 25-hydroxyvitamin D to calcitriol. Given this information we conducted a prospective study in toddlers and young children that suffered from atopic dermatitis aiming to identify the potential impact of vitamin D supplementation in the course of the…

Subjects/Keywords: Ατοπική δερματίτιδα; Βιταμίνη D; Καθελισιδίνη; Atopic dermatitis; Vitamin D; Cathelicidin

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Tsotra, K. (2017). Μελέτη για την πρόκληση παραγωγής καθελισιδίνης σε παιδιά με ατοπική δερματίτιδα μετά από χορήγηση βιταμίνης D. (Thesis). National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Retrieved from http://hdl.handle.net/10442/hedi/41769

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Chicago Manual of Style (16^th Edition):

Tsotra, Kyriaki. “Μελέτη για την πρόκληση παραγωγής καθελισιδίνης σε παιδιά με ατοπική δερματίτιδα μετά από χορήγηση βιταμίνης D.” 2017. Thesis, National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ). Accessed January 18, 2021. http://hdl.handle.net/10442/hedi/41769.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

MLA Handbook (7^th Edition):

Tsotra, Kyriaki. “Μελέτη για την πρόκληση παραγωγής καθελισιδίνης σε παιδιά με ατοπική δερματίτιδα μετά από χορήγηση βιταμίνης D.” 2017. Web. 18 Jan 2021.

Vancouver:

Tsotra K. Μελέτη για την πρόκληση παραγωγής καθελισιδίνης σε παιδιά με ατοπική δερματίτιδα μετά από χορήγηση βιταμίνης D. [Internet] [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2017. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/10442/hedi/41769.

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

Council of Science Editors:

Tsotra K. Μελέτη για την πρόκληση παραγωγής καθελισιδίνης σε παιδιά με ατοπική δερματίτιδα μετά από χορήγηση βιταμίνης D. [Thesis]. National and Kapodistrian University of Athens; Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ); 2017. Available from: http://hdl.handle.net/10442/hedi/41769

Note: this citation may be lacking information needed for this citation format:
Not specified: Masters Thesis or Doctoral Dissertation

McMaster University

30. Krisna, Sai Sakktee. Group 2 Innate Lymphoid Cells are Increased in Patients with Moderate-To-Severe Atopic Dermatitis.

Degree: MSc, 2018, McMaster University

URL: http://hdl.handle.net/11375/23392

► Introduction: Atopic dermatitis (AD) is characterized by chronic pruritic relapsing eczematous lesions of the skin. Eosinophilic inflammation in AD is driven by activation of type… (more)

▼ Introduction: Atopic dermatitis (AD) is characterized by chronic pruritic relapsing eczematous lesions of the skin. Eosinophilic inflammation in AD is driven by activation of type 2 inflammatory cells including CD4+ T cells and type 2 innate lymphoid cells (ILC2s). We have shown that type 2 cytokines, namely interleukin (IL)-5 and IL-13, stimulate migration and terminal differentiation of eosinophil progenitor cells (EoPs). We propose that these cytokines are important drivers of tissue eosinophilia in AD lesional skin. This study aimed to quantify, by flow cytometry, cells that produce type 2 cytokines in lesional skin compared to peripheral blood from moderate-severe AD patients. Methods: In a cross-sectional study of patients with moderate-to-severe AD (n=16), type 2 inflammatory cells were enumerated in blood and cells extracted from excised skin biopsies. By flow cytometry, live, singlet CD45+cells were identified as ILC2 (lin-CD127+CD294+), EoP (CD34+125+), and CD4+ T cells (Lin+CD3+CD4+). Intracellular expression of type 2 cytokines (IL-5 and IL-13) were evaluated in each cell population. In addition, we developed a protocol to enumerate ILC2s by fluorescence immune-histochemistry in lesional versus non-lesional skin samples and skin biopsies taken 24h post-intradermal challenge with allergen versus diluent. Data are expressed as median (interquartile range [IQR]) unless otherwise stated. Cross compartmental comparisons were made using the Wilcoxon rank-sum test and where applicable, correlational analyses were performed using a Spearman’s rank-correlational test. Results: There was a significantly higher number of total ILC2s in lesional skin compared to blood from AD subjects (556 [99 – 5501] vs 235 [67 – 569] cells/mL, p=0.03). Similarly, IL-5+, IL-13+ ILC2s, were significantly greater in skin compared to blood (6 [1 – 666] vs 1 [1 – 19] cells/mL, p=0.03; 28 [1 – 1357] vs 1 [1 – 7] cells/mL, p=0.01, respectively). We found higher numbers of total and type 2 cytokine positive EoP in lesional skin biopsies from AD patients compared to blood (Total EoP: 815 [285 – 2794] vs 112 [46 – 247] cells/mL, p<0.01; IL-5+EoP: 36 [1 – 129] vs 1 [1 – 23] cells/mL, p=0.07; IL-13+EoP: 92 [10 – 182] vs 1 [1 – 8] cells/mL, p<0.01 and IL-5+IL-13+ILC2: 70 [1 – 158] vs 1 [1 – 12] cells/mL, p=0.02, respectively). In contrast, significantly higher numbers of total and type 2 cytokine positive CD4+ cells were found in blood compared to lesional skin biopsies from AD patients (Total CD4+: 1092 [650 – 1742] vs 58.3 [35.3– 152.4] x 103 cells/mL, p<0.01 and IL-5+IL-13+CD4+ cells: 13.5 x 103 [2.1 x 103 – 42.9 x 103] vs 3.8 x 103 [1.6 x 103 – 4.9 x 103] cells/mL, p=0.02, respectively). For IF staining, there was a significant higher number of ILC2s in lesional compared to non-lesional skin biopsies and biopsies taken 24h post allergen- compared to diluent challenge (1 [0 – 2] vs 0 [0 - 0] cells/mm2, p=0.008, and 2 [1 – 2] vs 0 [0 – 0] cells/mm2, p=0.0002, respectively). Interestingly, in sex analyses we found significantly greater… Advisors/Committee Members: Sehmi, Roma, Medical Sciences.

Subjects/Keywords: Innate Lymphoid Cells; ILC2; Atopic Dermatitis; Group 2 Innate Lymphoid Cells

Record Details Similar Records Cite « Share

❌

APA · Chicago · MLA · Vancouver · CSE | Export to Zotero / EndNote / Reference Manager

APA (6^th Edition):

Krisna, S. S. (2018). Group 2 Innate Lymphoid Cells are Increased in Patients with Moderate-To-Severe Atopic Dermatitis. (Masters Thesis). McMaster University. Retrieved from http://hdl.handle.net/11375/23392

Chicago Manual of Style (16^th Edition):

Krisna, Sai Sakktee. “Group 2 Innate Lymphoid Cells are Increased in Patients with Moderate-To-Severe Atopic Dermatitis.” 2018. Masters Thesis, McMaster University. Accessed January 18, 2021. http://hdl.handle.net/11375/23392.

MLA Handbook (7^th Edition):

Krisna, Sai Sakktee. “Group 2 Innate Lymphoid Cells are Increased in Patients with Moderate-To-Severe Atopic Dermatitis.” 2018. Web. 18 Jan 2021.

Vancouver:

Krisna SS. Group 2 Innate Lymphoid Cells are Increased in Patients with Moderate-To-Severe Atopic Dermatitis. [Internet] [Masters thesis]. McMaster University; 2018. [cited 2021 Jan 18]. Available from: http://hdl.handle.net/11375/23392.

Council of Science Editors:

Krisna SS. Group 2 Innate Lymphoid Cells are Increased in Patients with Moderate-To-Severe Atopic Dermatitis. [Masters Thesis]. McMaster University; 2018. Available from: http://hdl.handle.net/11375/23392

		in
And / Or
		in
And / Or
		in
And / Or
		in

Open Access Theses and Dissertations